Anandamide on nitroglycerin-induced sensitization in the trigeminal system
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat by Nagy-Grocz, G., Tar, L., Bohar, Z., Fejes-Szabo, A., Laborc, K. F., Spekker, E., Vecsei, L., Pardutz, A. via Cephalalgia -- Preview Articles BackgroundOne of the human and animal models of migraine is the systemic administration of the nitric oxide donor (NO) nitroglycerin (NTG). NO can provoke migraine-like attacks in migraineurs and initiates a self-amplifying process in the trigeminal system, probably leading to central sensitization. Recent studies suggest that the end...περισσότερα »
Behavioral Analysis of Bitter Taste Perception
in Drosophila Larvae by Kim, H., Choi, M. S., Kang, K., Kwon, J. Y. via Chemical Senses Insect larvae, which recognize food sources through chemosensory cues, are a major source of global agricultural loss. Gustation is an important factor that determines feeding behavior, and the gustatory receptors (Grs) act as molecular receptors that recognize diverse chemicals in gustatory receptor neurons (GRNs). The behavior of*Drosophila* larvae is relatively simpler than the adult fly, and a gustatory receptor-to-neuron map was established in a previous study of the major external larval hea... περισσότερα »
Olfactory Identification Patterns among Parkinson's Disease Patients
Comparison of Olfactory Identification Patterns among Parkinson's Disease Patients from Different Countries by Millar Vernetti, P., Rossi, M., Cerquetti, D., Perez Lloret, S., Merello, M. via Chemical Senses Olfactory function assessment is an important screening tool and also may differentiate Parkinson’s disease (PD) patients from other parkinsonisms, including nondegenerative ones, such as, normal pressure hydrocephalus, vascular, drug induced, or infectious parkinsonism. Several authors in different countries have reported various sets of odors that best differentiate between the...περισσότερα »
Neonatal Multi-organ Failure due to ACAD9 Mutation and Complex I Deficiency with mitochondrial hyperplasia
in liver, cardiac myocytes, skeletal muscle and renal tubules via ScienceDirect Publication: Human Pathology Publication date: Available online 28 October 2015 *Source:*Human Pathology Author(s): Nancy Leslie, Xinjian Wang, Yanyan Peng, Alexander Valencia, Zaza Khuchua, Jessica Hata, David Witte, Taosheng Huang, Kevin E. Bove Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) genes miscode for Complex I subunits or assembly factors. ACAD9 is an acyl CoA dehydr... περισσότερα »
Undiagnosed Malignancies
Undiagnosed Fatal Malignancy in Adult Autopsies: A 10-year Retrospective Study via ScienceDirect Publication: Human Pathology Publication date: Available online 28 October 2015 *Source:*Human Pathology Author(s): Shobha Parajuli, Amandeep Aneja, Abir Mukherjee Autopsies reveal undiagnosed malignancies even in this era of modern diagnostic imaging and ancillary laboratory studies. The incidence of clinically undiagnosed malignancies related to primary cause of death in a university hospital setting has rarely been studied. Our objective was to determine the incidence of clinically undia...περισσότερα »
Antiangiogenesis, targeting vascular endothelial growth factor (VEGF)
Endothelin-1 and antiangiogenesis by Lankhorst, S., Danser, A. H. J., van den Meiracker, A. H. via AJP: Ahead of Print RSS feed Antiangiogenesis, targeting vascular endothelial growth factor (VEGF), has become a well-established treatment for patients with cancer. This treatment is associated with NO-suppression and a dose-dependent activation of the endothelin-system, resulting in preeclampsia-like features, particularly hypertension and renal injury. Studies in eNOS-deficient mice and pharmacological treatment with endothelin receptor blockers and sildenafil indicate that an activa...περισσότερα »
Heat and moisture exchangers (HMEs) and attachments after total laryngectomy
Patients’ experiences with by Gian Franco Macri, Hans Bogaardt, Claudio Parrilla, Antonio Minni, Lucia D'Alatri, Marcoc Vincentiis, Gaetano Paludettivia Clinical Otolaryngology Abstract Objectives The short-term and long-term beneficial effects of HME use by laryngectomees are well described in literature. In this study we document how laryngectomized patients, who previously did not use an HME, get accustomed to the use of HME and attachments. Participants Thirty patients, who were at least three months post-laryngectomy and previously did not use an HME, were followed for twelve wee...περισσότερα »
Supermicrosurgical free sensate superficial circumflex iliac artery perforator flap for reconstruction of a soft tissue defect
of the ankle in a 1-year-old child by Takuya Iida, Takumi Yamamoto, Hidehiko Yoshimatsu, Naho Abe, Masato Tsuchiya, Naho Nemoto, Shoji Watanabe viaMicrosurgery Although a superficial circumflex iliac artery perforator (SCIP) flap has recently been widely used owing to its various advantages, reports on its use in the pediatric population are limited. A case of a supermicrosurgical reconstruction of a soft tissue defect of the ankle associated with the congenital deficiency of the tibia using a free sensate SCIP flap in a 1-year-old child has been presented. The correction of the valg... περισσότερα »
Unresectable buccal mucosa cancers : Neoadjuvant chemotherapy and surgical margin
Neoadjuvant chemotherapy and surgical margin in technically unresectable buccal mucosa cancers by Pankaj Sahu, Vijay M. Patil, Amit Joshi, Vanita Noronha, Sachin Dhumal, Shubhada Kane, Anil D’Cruz, Kumar Prabhashvia Oral Oncology - Articles in Press R0 resection is the mainstay of treatment in advanced oral cancers [1]. A positive or close surgical margin is considered as an high risk factor for recurrence in oral cancers [2]. In our institute T4 oral cancers contribute to 80% of our margin positive resections [3]. T4 buccal mucosa cancers with peritumoral edema reaching up to or abo... περισσότερα »
HPV vaccination to prevent oropharyngeal carcinoma
: What can be learned from anogenital vaccination programs? by Robert P. Takes, Małgorzata Wierzbicka, Gypsyamber D’Souza, Joanna Jackowska, Carl E. Silver, Juan P. Rodrigo, Frederik G. Dikkers, Kerry D. Olsen, Alessandra Rinaldo, Ruud H. Brakenhoff, Alfio Ferlito via Oral Oncology - Articles in Press More than 200 types of human papillomavirus (HPV) exist. Only a few of these many HPV types are known to have oncogenic potential (Table 1). Other HPV types may produce mild intraepithelial low-grade lesions, recurrent respiratory papillomas (RRP), or may produce no apparent local tissue...περισσότερα »
Venom allergy testing
: is a graded approach necessary? by Jaclyn A. Quirt, Xia Wen, Jonathan Kim, Angel Jimenez Herrero, Harold L. Kim via Annals of Allergy, Asthma & Immunology Many institutions recommend a stepwise approach to intradermal testing for venom allergy. This is costly and uncomfortable for the patient. The rationale for this approach is the risk of potential adverse reactions to testing with the maximal dose alone. Tests and diagnosis By Mayo Clinic Staff If you've had a reaction to bee stings that suggests you might be allergic to bee venom, your doctor may suggest one or both of the follow...περισσότερα »
Breath alcohol levels after fluticasone nasal spray
Evaluation of by Jayan Vasudevan, Jeffrey Nelson, Russell Hopp via Annals of Allergy, Asthma & Immunology Fluticasone propionate nasal spray is widely prescribed for allergic rhinitis. Fluticasone propionate nasal spray, 50 μg, is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Fluticasone propionate nasal spray also contains microcrystalline cellulose and carboxymethylcellulose sodium, dextrose, 0.02% (wt/wt) benzalkonium chloride, polysorbate 80, and 0.25% (wt/wt) phenylethyl alc... περισσότερα »
Diurnal variation of CD63 expression on activated blood basophils
: a pilot study by Anja Baumann, Tina Skjold, Hans Jürgen Hoffmann, Axel Lorentz via Annals of Allergy, Asthma & Immunology Basophils contribute to immediate-type hypersensitivity reactions and to different diseases. Basophils are highly granulated leukocytes and can release their mediators in response to high-affinity IgE receptor crosslinking.1 The activation marker CD63 is present in secretory vesicles and expressed on the basophil cell surface after activation.2 The basophil activation test is a tool in clinical allergology to quantify in vitro activated basophils by flow cytomet... περισσότερα »
Pigmentation of the Lacrimal Sac Epithelium
.Jakobiec, Frederick A.; Stagner, Anna M.; Sutula, Francis C.; Freitag, Suzanne K.; Yoon, Michael K., 2015-10-26 07:00:00 AM Purpose: To describe the patterns of the melanocytic populations of 3 cases of lacrimal sac benign melanosis and 1 of atypical primary-acquired sac melanosis with a melanomatous nodule secondary to spread of atypical conjunctival primary-acquired melanosis to the sac. Methods: Clinical records, photographs, and paraffin sections stained with hematoxylin and eosin and the Fontana reaction were critically reviewed. Additional sections were immunoreacted for melan... περισσότερα »
Failed Cartilaginous Grafts in the Eyelid
: A Retrospective Clinicopathological Analysis of 5 Cases.MacIntosh, Peter W.; Jakobiec, Frederick A.; Stagner, Anna; Rashid, Alia; Sutula, Francis C.; Yoon, Michael K.; Fay, Aaron M., 2015-10-26 07:00:00 AM Purpose: To analyze the clinical and histopathologic features of 5 failed autologous cartilaginous grafts to the lower eyelids and to analyze the reasons for these failures. Methods: In this retrospective case series, the data collected included patient ages, reasons for and duration of cartilaginous graft implants, sources of cartilaginous grafts, and clinical and histopathologi... περισσότερα »
IgG4 Staining in Thyroid Eye Disease
.Kashani, Irwin; Rajak, Saul N.; Kearney, Daniel J.; Andrew, Nicholas H.; Selva, Dinesh, 2015-10-26 07:00:00 AM IgG4-related ophthalmic disease is increasingly widely recognized. Moreover, IgG4 staining can occur in other inflammatory diseases. The authors report a case of IgG4 staining of an enlarged, inflamed levator palpebrae superioris in a patient with a past history of thyroid eye disease. A 78-year-old woman with quiescent hyperthyroidism had clinical and radiological evidence of levator palpebrae superioris inflammation without superior rectus involvement. A biopsy was consis...περισσότερα »
Ptosis Surgery,Canthopexy
Conjunctiva-Sparing Posterior Ptosis Surgery: A Novel Approach.Vrcek, Ivan; Hogan, Robert N.; Rossen, Jennifer; Mancini, Ronald, 2015-10-26 07:00:00 AM Purpose: Muller's muscle conjunctiva resection is a well-established means of correcting blepharoptosis. The primary objective of this prospective study was to determine if modifying Muller's muscle conjunctiva resection by sparing the conjunctiva would accomplish successful repair while allowing patients to retain their conjunctiva. The potential advantages of preserving conjunctiva are significant and include: conservation of an ana... περισσότερα »
Langerhans Cell Histiocytosis Presenting as a Nodulo-Ulcerative Eyelid Lesion
Lo, Christopher; Patel, Payal; Charles, Norman C., 2015-10-26 07:00:00 AM The authors describe a 23-year-old man with unilateral upper eyelid swelling that evolved into a multinodular lesion with central necrosis, mimicking a neoplasm. Biopsy showed a lympho-histiocytic, eosinophil-rich proliferation with positivity for Langerhans cell markers CD1a and S-100 and histiocytic marker CD68. A literature review disclosed 11 documented cases of Langerhans cell histiocytosis of the eyelid with variable clinical presentations. This rare eyelid lesion, nearly always solitary, has no clinical... περισσότερα »
The J-Curve for Navigating the Nasolacrimal Outflow Tract
Sobti, Deepak; Walk, Daniel; Finnerty, Katie; Mancini, Ronald, 2015-10-26 07:00:00 AM Purpose: To describe the technique of J-shaped manipulation of the metallic stent for instrument-free intubation of the nasolacrimal outflow tract after dacryocystorhinostomy. Methods: The internal diameter of the J-shaped curve placed in the intubation stents was measured and the technique of intubation of the nasolacrimal outflow tract and out the external naris is described. In addition, the anatomic relationships of the nasolacrimal system are illustrated and videographed in relation to the des... περισσότερα »
Extensive Recurrent Periocular Basal Cell Carcinoma with Orbital Invasion
Secondary Resistance to Vismodegib After Initial Successful Treatment of ...Papastefanou, Vasilios P.; René, Cornelius, 2015-10-26 07:00:00 AM Vismodegib is proven to be effective in the treatment of locally advanced and metastatic basal cell carcinoma, but evidence of resistance is beginning to emerge. A case of advanced recurrent periocular basal cell carcinoma which responded dramatically to vismodegib after 3 months but recurred after 9 months due to drug resistance, eventually requiring orbital exenteration, is presented. The mechanism of vismodegib resistance is discussed. (C) ... περισσότερα »
Temporal Fossa Volume
Comparison of Temporal Fossa Volume in Young Versus Senescent Human Skulls.Zhao, Yue; Chundury, Rao V.; Perry, Julian D., 2015-10-26 07:00:00 AM Purpose: To determine whether bony changes in the temporal fossa occur with age. Methods: Human skulls within 2 age groups from the Hamann-Todd collection at the Cleveland Natural History Museum (Cleveland, Ohio, U.S.A.) were studied. The young group of skulls consisted of adults aged 18 to 30 years, and the senescent group of skulls consisted of individuals aged over 69 years. A modeling compound molded to each temporal fossa in an identica... περισσότερα »
Pseudomonas Aeruginosa: A Masquerader in Sino-Orbital Infections
Chen, Xi; Bleier, Benjamin S.; Lefebvre, Daniel R.; Lee, Nahyoung Grace, 2015-10-26 07:00:00 AM Purpose: To report 2 immunocompromised patients with sino-orbital necrotizing pseudomonas infections and review the literature. Methods: This is a noncomparative, retrospective case series, and review. The clinical data of 2 patients with histopathologic and microbiologic diagnoses of pseudomonas sinus infections causing orbital cellulitis were obtained from medical records. A retrospective literature review was performed on all reported cases of periorbital pseudomonas infections. Result...περισσότερα »
Levamisole-Associated Vasculitis.Eyelid Necrosis and Secondary Cicatrical Ectropion
Eyelid Necrosis and Secondary Cicatrical Ectropion Secondary to Levamisole-Associated Vasculitis.Ramesh, Sathyadeepak; Sobti, Deepak; Mancini, Ronald, 2015-10-26 07:00:00 AM A 56-year-old female presented with eyelid necrosis secondary to systemic levamisole-induced vasculitis. Skin biopsy revealed necrotic epidermis with small-vessel thrombosis, fibrinoid reaction, and neutrophilic infiltration of vessel walls in the dermis with +pANCA. She was treated with plasmapheresis and steroids. Six months later, she developed severe, symptomatic cicatrical ectropion with marked anterior lame... περισσότερα »
Local Resection and Brachytherapy for Primary Orbital Rhabdomyosarcoma
: Outcome and Failure Pattern Analysis.Schoot, Reineke A.; Saeed, Peerooz; Freling, Nicole J.; Blank, Leo E. C. M.; Pieters, Bradley R.; van der Grient, Johan N. B.; Strackee, Simon D.; Bras, Johannes; Caron, Huib N.; Merks, Johannes H. M.; on behalf of the Amsterdam Head and Neck Working Group on Childhood Tumors, 2015-10-26 07:00:00 AM Purpose: Survival in patients with orbital rhabdomyosarcoma (RMS) is excellent. Therefore, new local treatment modalities, such as brachytherapy, have been developed to minimize adverse events. Since 1990, patients with orbital RMS and a residual tum... περισσότερα »
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