Tracheostomy Complications as a Trigger for an Airway Rapid Response
: Analysis and Quality Improvement Considerations by Rassekh, C. H., Zhao, J., Martin, N. D., Chalian, A. A., Atkins, J. H. via Otolaryngology -- Head and Neck Surgery RSS feed -- OnlineFirst Articles ObjectiveTo analyze the subset of airway rapid response (ARR) calls related to tracheostomy identified over a 46-month period from August 2011 to May 2015 to determine proximate cause, intervention, and outcome and to develop process improvement initiatives. DesignSingle-institution multidisciplinary retrospective cohort study. SettingTertiary care academic medical center in a large urban ...περισσότερα »
Paranasal Sinus Balloon Catheter Dilation for Treatment of Chronic Rhinosinusitis
: A Systematic Review and Meta-analysis by Levy, J. M., Marino, M. J., McCoul, E. D. via Otolaryngology -- Head and Neck Surgery RSS feed -- OnlineFirst Articles ObjectiveParanasal sinus balloon catheter dilation (BCD) represents a commonly used tool in the management of chronic rhinosinusitis (CRS) for which the indications, utilization, and outcomes have not been well established. A systematic review and meta-analysis were undertaken to evaluate change in quality of life and sinus opacification following paranasal sinus BCD in the treatment of CRS. Data SourcesMEDLINE and EMBASE dat...περισσότερα »
Reduction of Pharyngocutaneous Fistulae in Laryngectomy Patients
by a Comprehensive Performance Improvement Intervention by Li, R. J., Zhou, X. C., Fakhry, C., Negrin, J., Lee, G., Ha, P., Blanco, R., Saunders, J., Califano, J. A. via Otolaryngology -- Head and Neck Surgery RSS feed -- OnlineFirst Articles ObjectivePharyngocutaneous fistula is a common complication in laryngectomy patients, particularly in previously irradiated cases. We initiated a comprehensive performance improvement intervention in all head and neck surgery patients intended to reduce postoperative infection and fistulae rates. We report our review of outcomes within laryngect... περισσότερα »
In surgery for acute subdural haematoma (ASDH), the bone flap can be fixed onto the skull, or left “riding” to provide partial skull decompression, or removed
: replace or remove the bone flap? via World Neurosurgery Publication date: Available online 31 October 2015 *Source:*World Neurosurgery Author(s): Georgios Tsermoulas, Omid Shah, Haren Eranga Wijesinghe, Adikarige Haritha Dulanka Silva, Satheesh K. Ramalingam, Antonio Belli ObjectiveIn surgery for acute subdural haematoma (ASDH), the bone flap can be fixed onto the skull, or left “riding” to provide partial skull decompression, or removed. This study assessed whether removing the bone flap improved outcome.MethodsWe conducted an observational study in consecutive patients who were ope... περισσότερα »
Tarlov cysts,also known as perineural cysts,are type II innervated meningeal cysts, cerebrospinal-fluid-filled (CSF) sacs most frequently located in the spinal canal of the S1-to-S5 region of the spinal cord (much less often in the cervical, thoracic or lumbar spine)
Tarlov cyst From Wikipedia, the free encyclopedia Tarlov cyst[image: Cisti Tarlov RM coron.jpg] MRI image showing a Tarlov cyst. Classification and external resourcesICD-9-CM355.9DiseasesDB32082 *Tarlov cysts*, also known as perineural cysts,[1] are type II innervated meningeal cysts, cerebrospinal-fluid-filled (CSF) sacs most frequently located in the spinal canal of the S1-to-S5 region of the spinal cord (much less often in the cervical, thoracic or lumbar spine), and can be distinguished from other meningeal cysts by their nerve-fiber-filled walls. Tarlov cysts are defined as cysts... περισσότερα »
The surface anatomy of the central venous system in children : The superior vena cava/right atrial (SVC/RA) junction, superior vena cava (SVC) formation, and brachiocephalic vein (BCV) formation
Defining by Gregory P. Tarr, Neda Pak, Kiarash Taghavi, Tom Iwan, Charlotte Dumble, David Davies-Payne, S. Ali Mirjalili viaClinical Anatomy Abstract Pediatric emergency physicians, pediatric critical care specialists and pediatric surgeons perform central venous catheterization in many clinical settings. Complications of the procedure are not uncommon and can be fatal. Despite the frequency of application, the evidence-base describing the surface landmarks involved is missing. The aim of the current study was to investigate the surface markings of the central venous system in childr... περισσότερα »
Oral Diseases
- Design and interpretation of clinical research studies in oral medicine: A brief reviewJane C. Atkinson, David B. Clark, 2015-10-31 12:37:58 AM Abstract The objective of this short review is to help researchers improve the designs of their clinical studies. Also included is a discussion of the level of evidence provided by the various clinical research study designs. This article is protected by copyright. All rights reserved. Read moreTop - Human Factors- recognising and minimising errors in our day to day practiceBen Green, Constantine Tsiroyannis... περισσότερα »
Pediatric Mechanical external nasal dilators (MEND)
Objective and subjective responses to a mechanical external nasal dilator in healthy children and children with nasal congestion Authors: Meltzer, Eli O.; Johnson, Steven Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 481-486(6) Publisher: OceanSide Publications, Inc Background: Nasal congestion is a frequent symptom of allergic rhinitis. Mechanical external nasal dilators (MEND) can be applied to the outside of the nose to provide temporary relief from nasal stuffiness. Objective: To assess the objective and subjective benefits and tolera...περισσότερα »
In patients with CRS, IgA class AAbs were detected in NS, whereas the highest levels of anti-IL-5 and anti-IL-17A AAbs were detected in patients with CRSwNP. Maybe these AAbs indicate disruption of immune tolerance and mucosal autoimmunity.
Anticytokine autoantibodies in chronic rhinosinusitis Authors: Tsybikov, Namjil N.; Egorova, Elena V.; Kuznik, Boris I.; Fefelova, Elena V.; Magen, Eli Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 473-480(8) Publisher: OceanSide Publications, Inc Background: Anticytokine autoantibodies (AAbs) involve a great panel of cytokines both in healthy subjects and in patients with various diseases, but their incidence and pathophysiologic role are widely debated. The issue of AAbs in chronic rhinosinusitis (CRS) has never been explored. Objective:...περισσότερα »
The association between thyroid autoimmunity (TA) and idiopathic isolated angioedema (or angioedema without urticaria)
Association between thyroid autoimmunity and recurrent angioedema in children Authors: Karagol, Hacer Ilbilge Ertoy; Yilmaz, Ozlem; Topal, Erdem; Bideci, Aysun; Bakirtas, Arzu Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 468-472(5) Publisher: OceanSide Publications, Inc Background: The association between thyroid autoimmunity (TA) and idiopathic isolated angioedema (or angioedema without urticaria) has not been evaluated in either children or in adults up until now. We, therefore, aimed to investigate underlying or concomitant TA and/or au... περισσότερα »
High anxiety has been reported in patients with drug hypersensitivity reaction (DHR)
Evaluation of anxiety levels and factors associated with positive test results in patients with drug hypersensitivity Authors: Comert, Sule; Erdogan, Tuba; Demir, Ahmet Ugur; Karakaya, Gul; Kalyoncu, Ali Fuat Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 439-446(8) Publisher: OceanSide Publications, Inc Background: High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously. Objective: We aimed to investigate the association of patient an...περισσότερα »
Hereditary angioedema (HAE)
Hereditary angioedema: Special consideration in children, women of childbearing age, and the elderly Authors: Kuhlen, James L.; Banerji, Aleena Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 425-432(8) Publisher: OceanSide Publications, Inc This review on hereditary angioedema (HAE) focused on special topics regarding HAE in children, women of childbearing age, and the elderly. HAE is a rare autosomal dominant bradykinin-mediated disorder characterized by recurrent attacks of subcutaneous or submucosal swelling that usually affects the face, u... περισσότερα »
Asthma, allergy, and psychiatric disease
*Examining Impacts of Allergic Diseases on PsychologicalProblems ...* *journals.plos.org/plosone/article?id=10.1371/journal.pone...* *Apr 21, 2015 ... We examined the impact of asthma and other allergic diseases onpsychological symptoms and health risk behaviors among South Korean ...* Allergies and suicidal behaviors: A systematic literature review *Authors: Kõlves, Kairi; Barker, Emma; De Leo, DiegoSource: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. 433-438(6)Publisher: OceanSide Publications, Inc* *Background:* *Allergies are among the most comm... περισσότερα »
PB CD14+ HLA-DR+ TLR2+ monocytes might have a role in the skewing of a T-helper 2/T-helper 17‐mediated immune response during AD flare
Expression of TLR2 and TLR4 on peripheral blood monocytes during exacerbation of atopic dermatitis Authors: Tsybikov, Namjil N.; Petrisheva, Irina; Fefelova, Elena V.; Kuznik, Boris I.; Magen, Eli Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. e140-e145(6) Publisher: OceanSide Publications, Inc Background: In atopic dermatitis (AD), monocytes, which accumulate in the inflamed skin, are characterized by a significantly impaired Toll-like receptors (TLR) expression and TLR2-mediated cytokine secretion. However, data on expression of TLR on mon...περισσότερα »
Micronized cellulose powder + Topical oxymetazoline in allergic rhinitis
Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis Authors: Valerieva, Anna; Popov, Todor A.; Staevska, Maria; Kralimarkova, Tanya; Petkova, Elena; Valerieva, Elitsa; Mustakov, Tihomir; Lazarova, Tsvetelina; Dimitrov, Vasil; Church, Martin K. Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. e134-e139(6) Publisher: OceanSide Publications, Inc Background: Defective nasal barrier function is implicated in allergic rhinitis, which results in persistent inflammation and clinical symptoms, among which ...περισσότερα »
Atopic skin integrity by means of transepidermal water loss (TEWL) and Corneometer : Barrier integrity measurements and the degree of sensitization to aeroallergens (allergy score)
Correlation of skin barrier impairment in atopic dermatitis with aeroallergen sensitization Authors: De Marchi, Federica; Piacentini, Giorgio L.; Piazza, Michele; Sandri, Marco; Boner, Attilio L.; Peroni, Diego G. Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. e127-e133(7) Publisher: OceanSide Publications, Inc Background: Atopic dermatitis (AD) often predates the development of allergic sensitization in the so-called atopic march. Several studies have pointed out epidermal barrier impairment as a major cause of this evolution. Objective: ... περισσότερα »
YouTube videos of asthma : The educational quality
Popular on YouTube: A critical appraisal of the educational quality of information regarding asthma Authors: Gonzalez-Estrada, Alexei; Cuervo-Pardo, Lyda; Ghosh, Bitan; Smith, Martin; Pazheri, Foussena; Zell, Katrina; Wang, Xiao-Feng; Lang, David M. Source: Allergy and Asthma Proceedings, Volume 36, Number 6, November/December 2015, pp. e121-e126(6) Background: Asthma affects >300 million people globally, including 25 million in the United States. Patients with asthma frequently use the Internet as a source of information. YouTube is one of the three most popular Web sites. Object... περισσότερα »
The serum level of eosinophil-derived neurotoxin (EDN) : persistent airflow limitation in adults with house-dust mite allergic asthma
Serum eosinophil-derived neurotoxin: Correlation with persistent airflow limitation in adults with house-dust mite allergic asthma Abstract:Background: The serum level of eosinophil-derived neurotoxin (EDN), a protein present in eosinophil granules, correlates with the severity of childhood asthma. However, the relationship between the serum EDN level and the severity of adult asthma has not been sufficiently investigated. Objective: This study aimed to elucidate the correlation between the serum EDN level and markers of severity in adult asthma. Methods: The subjects compri... περισσότερα »
Risk relation between rhinitis and acute ischemic stroke
Risk relation between rhinitis and acute ischemic stroke by Tseng, Chun-Hung via Latest Issue of Allergy and Asthma Proceedings Abstract: *Background and Purpose:* Chronic inflammation that triggers endothelial dysfunction and atherosclerosis may promote the evolution of cardiovascular diseases, including acute ischemic stroke (AIS). In this study, we assessed the association between rhinitis (RN), an immunoglobulin E-related atopic disease, and the risk of AIS. *Methods:* We used a Taiwan national insurance claims data set of 1 million enrollees to distinguish 61,899 patients...περισσότερα »
Metabolic Effects of Obstructive Events
Turning Dreams into Nightmares: Different Metabolic Effects of Obstructive Events in Rapid Eye Movement versus Non–Rapid Eye Movement Sleep by Tetyana Kendzerska via American Thoracic Society: American Journal of Respiratory and Critical Care Medicine: Table of Contents [image: rccm.201507-1504ed.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 192, Issue 9, Page 1034-1035, November 1, 2015.
NOD2 Pathway Genes in Sarcoidosis
Role of NOD2 Pathway Genes in Sarcoidosis Cases with Clinical Characteristics of Blau Syndrome by Ghalib A. Bello via American Thoracic Society: American Journal of Respiratory and Critical Care Medicine: Table of Contents [image: rccm.201507-1344le.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 192, Issue 9, Page 1133-1135, November 1, 2015.
Blau syndrome is characterized by familial granulomatous arthritis, uveitis, and skin granulomas
Blau syndrome From Wikipedia, the free encyclopedia Blau syndrome[image: Blau syndrome2.jpg] Coarse facial features in a boy with Blau syndrome Classification and external resourcesOMIM186580DiseasesDB32725 Multiple, reddish-brown papules coalescing over the right arm in a boy with Blau syndrome *Blau syndrome* is characterized by familial granulomatous arthritis, uveitis, and skin granulomas, comprising an autosomal dominantly inherited syndrome that overlaps both sarcoidosis and granuloma annulare.[1][2] Restated, Blau syndrome is a rare autosomal dominant disorder characterized by ...περισσότερα »
Clinical Faces of Obstructive Sleep Apnea (OSA)
doi: 10.1164/rccm.201507-1472RR The Different Clinical Faces of Obstructive Sleep Apnea (OSA), OSA in Older Adults as a Distinctly Different Physiological Phenotype, and the Impact of OSA on Cardiovascular Events after Coronary Artery Bypass Surgery Clodagh M. Ryan, Tetyana Kendzerska, Kelly Wilton, and Owen D. Lyons -Author Affiliations - Division of Respirology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada - *Recommended Reading from the University of Toronto Sleep Medicine Fellowship Program; Clodagh M. Ryan, M.D., Director of the Fellowship ... περισσότερα »
Indacaterol/glycopyrrolate (trade name Ultibro Breezhaler®)
doi: 10.1164/rccm.201505-1048OC FLIGHT1 and FLIGHT2: Efficacy and Safety of QVA149 (Indacaterol/Glycopyrrolate) versus Its Monocomponents and Placebo in Patients with Chronic Obstructive Pulmonary Disease Donald A. Mahler1,2, Edward Kerwin3, Tim Ayers4, Angel FowlerTaylor4, SamopriyoMaitra5, Chau Thach4, Mark Lloyd4, Francesco Patalano6, and Donald Banerji4 See related editorial -Author Affiliations - 1Geisel School of Medicine at Dartmouth, Hanover, New Hampshire - 2Valley Regional Hospital, Claremont, New Hampshire - 3Clinical Research Institute of Southern Oregon, Medford,... περισσότερα »
Cycling and Walking
Effects of Mild Chronic Obstructive Pulmonary Disease on Gas Exchange during Cycling and Walking by Alejandro A. Diaz via American Thoracic Society: American Journal of Respiratory and Critical Care Medicine: Table of Contents [image: rccm.201507-1361le.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 192, Issue 9, Page 1137-1138, November 1, 2015.
Prenatal Particulate Air Pollution and Asthma Onset in Urban Children
doi: 10.1164/rccm.201504-0658OC Prenatal Particulate Air Pollution and Asthma Onset in Urban Children. Identifying Sensitive Windows and Sex Differences Hsiao-Hsien Leon Hsu1, Yueh-Hsiu Mathilda Chiu2, Brent A. Coull3,4, Itai Kloog4,5, JoelSchwartz4,6, Alison Lee7, Robert O. Wright1,8, and Rosalind J. Wright2,8 See related editorial -Author Affiliations - 1Department of Preventive Medicine - 2Kravis Children’s Hospital, Department of Pediatrics - 7Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, and - 8The Mindich Child Health & Developm...περισσότερα »
Association between Glucose Metabolism and Sleep-disordered Breathing
doi: 10.1164/rccm.201501-0046OC Association between Glucose Metabolism and Sleep-disordered Breathing during REM Sleep Hassan A. Chami1,2, Daniel J. Gottlieb3,4, Susan Redline4, and Naresh M. Punjabi5 See related editorial -Author Affiliations - 1Department of Medicine, American University of Beirut, Beirut, Lebanon - 2Department of Medicine, Boston University School of Medicine, Boston, Massachusetts - 3VA Boston Healthcare System, Boston, Massachusetts - 4Department of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical...περισσότερα »
Greenness and Incident Childhood Asthma
doi: 10.1164/rccm.201504-0707LE Greenness and Incident Childhood Asthma: A 10-Year Follow-up in a Population-based Birth Cohort Hind Sbihi Ph.D. 1, Lillian Tamburic B.Sc. 1, Mieke Koehoorn Ph.D. 1, and MichaelBrauer Sc.D. 1 -Author Affiliations - 1University of British Columbia Vancouver, British Columbia, Canada [image: Free first page]
Orbital Intubation
An Urgent Airway by Jonah Cohen via American Thoracic Society: American Journal of Respiratory and Critical Care Medicine: Table of Contents [image: rccm.201506-1134im.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 192, Issue 9, Page e53-e53, November 1, 2015.
Middle East Respiratory Syndrome
Reply: Middle East Respiratory Syndrome: A Concern by David S. Hui via American Thoracic Society: American Journal of Respiratory and Critical Care Medicine: Table of Contents [image: rccm.201507-1485le.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 192, Issue 9, Page 1135-1136, November 1, 2015.
Combining Rapamycin and Resveratrol on Apoptosis and Growth of TSC2-Deficient Xenograft Tumors
doi: 10.1165/rcmb.2015-0022OC Effects of Combining Rapamycin and Resveratrol on Apoptosis and Growth of TSC2-Deficient Xenograft Tumors Anya Alayev1*, Rachel S. Salamon1*, Yang Sun2, Naomi S. Schwartz1, Chenggang Li2,Jane J. Yu2, and Marina K. Holz3,4 -Author Affiliations - 1Department of Biology, Stern College for Women of Yeshiva University, New York, New York - 2Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts - 3Department of Biology, Yeshiva University, New York, New ...περισσότερα »
Organophosphorus Pesticide–Induced Airway Hyperreactivity
doi: 10.1165/rcmb.2014-0444OC The Influence of Sensitization on Mechanisms of Organophosphorus Pesticide–Induced Airway Hyperreactivity Becky J. Proskocil1, Donald A. Bruun2, Jasmine A. Garg1, Chloe C. Villagomez1, David B. Jacoby1, Pamela J. Lein2, and Allison D. Fryer1 -Author Affiliations - 1Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon; and - 2Department of Molecular Biosciences, University of California School of Veterinary Medicine, Davis, California Corresponding Author: Becky J. Proskocil Abstract We previously de... περισσότερα »
S100 proteins were reduced in patients with chronic rhinosinusitis (CRS)
doi: 10.1165/rcmb.2015-0207RC Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling Seong H. Cho1,2,3*, Dae Woo Kim2,4*, Sun H. Lee1, Narasaiah Kolliputi2, Seung J. Hong3,Lydia Suh1, James Norton1, Kathryn E. Hulse1, Sudarshan Seshadri1, David B. Conley5,Robert C. Kern5, Bruce K. Tan5, Anju Peters1, Leslie C. Grammer1, and Robert P.Schleimer1,5 -Author Affiliations - 1Division of Allergy-Immunology, Department of Medicine, and - 5Department of Otolaryngology, Northwestern Feinberg School of ...περισσότερα »
Airway hyperresponsiveness and remodeling in asthma
doi: 10.1165/rcmb.2014-0386OC Ryanodine Receptor Sensitization Results in Abnormal Calcium Signaling in Airway Smooth Muscle Cells Huguette Croisier1, Xiahui Tan2, Jun Chen3, James Sneyd4, Michael J. Sanderson3, andBindi S. Brook1 -Author Affiliations - 1School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom - 2Lung Inflammation and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia - 3Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester...περισσότερα »
Statin-Conferred Enhanced Cellular Resistance against Bacterial Pore-Forming Toxins
doi: 10.1165/rcmb.2014-0391OC Statin-Conferred Enhanced Cellular Resistance against Bacterial Pore-Forming Toxins in Airway Epithelial Cells Sarah Statt1*, Jhen-Wei Ruan2*, Li-Yin Hung1, Ching-Yun Chang1, Chih-Ting Huang2, Jae Hyang Lim3, Jian-Dong Li4, Reen Wu1, and Cheng-Yuan Kao1,2 -Author Affiliations - 1Center for Comparative Respiratory Biology and Medicine, University of California at Davis, Davis, California - 2Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli, Taiwan - 3Department of Microbiology, Ewha Womans University School of ... περισσότερα »
Tissue factor (TF) initiates the extrinsic coagulation cascade in response to tissue injury, leading to local fibrin deposition
doi: 10.1165/rcmb.2014-0179OC Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor Ciara M. Shaver1, Brandon S. Grove1, Nathan D. Putz1, Jennifer K. Clune1, William E.Lawson1,2, Robert H. Carnahan3, Nigel Mackman4, Lorraine B. Ware1,5, and Julie A.Bastarache1 -Author Affiliations - 1Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee - 2Department of Veterans Affairs Medical Center, Nashville, Tennessee - 3... περισσότερα »
3-phase dual-energy CT scan for the identification of non-localizing parathyroid adenomas
3-phase dual-energy CT scan as a feasible salvage imaging modality for the identification of non-localizing parathyroid adenomas: a prospective study by Michael Roskies via Journal of Otolaryngology - Head & Neck Surgery ObjectivesAccurate pre-operative imaging of parathyroid adenomas (PAs) is essential for successful minimally invasive surgery; however, rates of non-localizing PAs can be as high as 18 %. Multiphasic dual-energy CT (DECT) has the potential to increase accuracy of PA detection by enabling creation of paired material maps and spectral tissue characterization. This study... περισσότερα »
Exogenous Cues on Covert Spatial Orienting in Deaf
Effect of Exogenous Cues on Covert Spatial Orienting in Deaf and Normal Hearing Individuals by Seema Gorur Prasad et al. via PLOS ONE by Seema Gorur Prasad, Gouri Shanker Patil, Ramesh Kumar Mishra Deaf individuals have been known to process visual stimuli better at the periphery compared to the normal hearing population. However, very few studies have examined attention orienting in the oculomotor domain in the deaf, particularly when targets appear at variable eccentricity. In this study, we examined if the visual perceptual processing advantage reported in the deaf people also modu...περισσότερα »
The use of desiccation to treat staphylococcus aureus biofilm infected wounds
The use of desiccation to treat staphylococcus aureus biofilm infected wounds by Eugene Park, Sarah A. Long, Akhil K. Seth, Matthew Geringer, Wei Xu, Claudia Chavez-Munoz, Kai Leung, Seok Jong Hong, Robert D. Galiano, Thomas A. Mustoe via Wound Repair and Regeneration Abstract Chronic wounds colonized with biofilm present a major burden to our healthcare system. While the current paradigm for wound healing is to maintain a moist environment, we sought to evaluate the effects of desiccation, and the ability of honey to desiccate wounds, on wound healing characteristics in *Staphylococ...περισσότερα »
Wound Repair and Regeneration
- The natural behavior of mononuclear phagocytes in HTS formationZhensen Zhu, Jie Ding, Zengshuan Ma, Takashi Iwashina, Edward E Tredget, 2015-10-31 11:30:39 AM Abstract Hypertrophic scars are caused by trauma or burn injuries to the deep dermis and are considered fibrosis in the skin. Monocytes, M1 and M2 macrophages are mononuclear phagocytes. Studies suggest that M2 macrophages are pro-fibrotic and might contribute to hypertrophic scars formation. Our lab has established a human HTS-like nude mouse model, in which the grafted human skin develops red... περισσότερα »
Contaminant release history identification in 2-D heterogeneous aquifers through a minimum relative entropy approach
The minimum relative entropy (MRE) method has been applied in a wide variety of fields since it was first introduced. Woodbury and Ulrych (Water Resour Res 29(8): 2847–2860, 1993 , Water Resour Res 32(9): 2671–2681, 1996 ) adopted and improved this method to solve linear inverse problems in aquifers. In this work, the MRE method was improved to detect the source release history in 2-D aquifer characterized by a non-uniform flow-field. The approach was tested on two cases: a 2-D homogeneous conductivity field and a heterogeneous one (the hydraulic conductivity presents three orders ...περισσότερα »
Medicine,New Articles,October 31st,2015
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity to... περισσότερα »
Medicine,New Articles,October 31st,2015
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity t... περισσότερα »
Medicine,New Articles,October 31st,2015
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity to... περισσότερα »
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product. Graphical abstract [image: image] from #Medicine via ola Kala on Inoreader http:...περισσότερα »
1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Silvija Maračić, Tatjana Gazivoda Kraljević, Hana Čipčić Paljetak, Mihaela Perić, Mario Matijašić, Donatella Verbanac, Mario Cetina, Silvana Raić-Malić Versatile 1,2,3-triazole pharmacophore-based benzofused heterocycles containing halogen-substituted aromatic (9–17 and 25–28), 7-substituted coumarin (18–23 and 29–30) or penciclovir-like subunit (31a,b–38a) were designed and synthesized to evaluate their antibacterial activities against selected Gram-positive and Gram-negative bac... περισσότερα »
Discovery of bis-ary urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Jiaxin Cui, Mei Ding, Wei Deng, Yan Yin, Zhonghua Wang, Hong Zhou, Guofeng Sun, Yu Jiang, Yangbo Feng Lim kinase (Limk), a proline/serine-rich sequence, can regulate the polymerization of the actin filaments by phosphorylating, and it is found to be highly involved in various human diseases. In this paper, 47 reported Limk1 inhibitors with bis-ary urea scaffold were used to design potent and selective Limk inhibitors by computational approaches. Firstly, the structure-Limk1 activi... περισσότερα »
Synthesis of di- and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues
Publication date: Available online 30 October 2015 *Source:*Bioorganic & Medicinal Chemistry Author(s): Matteo Fusari, Silvia Fallarini, Grazia Lombardi, Luigi Lay Zwitterionic polysaccharides (ZPS) behave like traditional T cell-dependent antigens, suggesting the design of new classes of vaccines alternative to currently used glycoconjugates and based on the artificial introduction of a zwitterionic charge motif onto the carbohydrate structure of pathogen antigens. Here we report the new synthesis and antigenic evaluation of di-/tri-saccharide fragments of Salmonella typhi Vi polysa...περισσότερα »
Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings
Background: The root of Angelica dahurica Bentham et Hooker (Umbelliferae) has been used as a traditional medicine for colds, headache, dizziness, toothache, supraorbital pain, nasal congestion, acne, ulcer, carbuncle, and rheumatism in China, Japan, and Korea. Interestingly, it has been used in the treatment of vascular diseases including hypertension. The aim of this study was to provide pharmacological evidence for the anti-hypertensive effect of A. dahurica by investigating the mechanism underlying its vasorelaxant effect. Methods: The vasorelaxant effects of a 70 % methanol e... περισσότερα »
Retrospective case-series of Paecilomyces lilacinus ocular mycoses in Queensland, Australia
Background: The purpose of this study was to report: (1) the varying presentation of Paecilomyces ocular infections arising in Queensland; (2) the significance of immunosuppression as a primary determinant of disease; (3) the outcomes of voriconazole use; and (4) the ongoing need for both surgical and medical management of this devastating fungal infection. Methods: A retrospective case series of 21 culture proven individuals participated in this series and were identified via a review of the pathology reporting system utilized in the Queensland public health system. All culture p... περισσότερα »
Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry
Background: Pasteurella multocida meningitis in an immunocompetent patient is rare and commonly occurs after animal bite. To our knowledge, only 48 cases have been reported in the literature since 1989. P. multocida meningitis is commonly linked to animal contagion. Here we report on a new case of P. multocida meningitis in an immunocompetent patient who is a dog owner without a dog bite. We used the matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry to investigate the clonal lineage between animal and human isolates.Case presentationIn our ca...περισσότερα »
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