Eyelid fat grafting: indications, operative technique and complications; a systematic review
Publication date: Available online 18 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Elodie Boureaux, Benoit Chaput, Sahar Bannani, Christian Herlin, Antoine De Runz, Raphael Carloni, Bruno Mortemousque, Frederic Mouriaux, Eric Watier, Nicolas Bertheuil IntroductionMany recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a com...περισσότερα »
Discopexy using resorbable pins in temporomandibular joint arthroscopy: Clinical and magnetic resonance imaging medium-term results
Publication date: Available online 18 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Rafael Martín-Granizo, Alejandrina Millón-Cruz PurposeTo describe the use of resorbable pins for disc fixation in a serie of patients and their medium-term outcomes.Materials and MethodsA study was conducted in 26 patients who underwent operative arthroscopic surgery and discopexy using resorbable pins. All patients were refractory to conservative treatment and presented, in at least one joint, anterior disc displacement without reduction on magnetic resonance imaging (MRI)....περισσότερα »
Three-dimensional analysis of maxillary stability after Le Fort I osteotomy using hydroxyapatite/poly-L-lactide plate
Publication date: Available online 19 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Jung Hyun Park, Minkyu Kim, Sang Yoon Kim, Hwi-Dong Jung, Young-Soo Jung PurposeTo evaluate three-dimensional change in maxillary position using biodegradable plates.Material and MethodsA total of 53 patients who underwent orthognathic surgery using biodegradable plates were analyzed retrospectively. The position of maxilla was measured three-dimensionally using cone beam computed tomography data at preoperative (T0), 1-month postoperative (T1), and 1-year postoperative (T2... περισσότερα »
Caliber persistent labial artery (CPLA): A rarely recognized cause of a lower lip swelling. Report of 5 cases and review of the literature
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): S Awni Mclin, B. Conn Caliber persistent labial artery (CPLA) is a vascular anomaly of the labial artery which penetrates into submucosa of the lip without reduction in diameter. It commonly presents as a bluish or normal color elevated soft tissue mass and usually pulsates on manual palpation.Five patients aged between 28 and 88 years old presenting with discrete lesions of the lower lip are presented. All cases were treated with excision biopsy. Persistence of the lesio... περισσότερα »
Immediate Versus Delayed Treatment of Mandibular Fractures: A Stratified Analysis of Complications
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Urie K. Lee, Ayleen Rojhani, Alan S. Herford, Jayini S. Thakker PurposeTo analyze the rate of complication outcomes of mandibular fracture repairs across different injury-to-repair time spans.Patients and MethodsThe investigators conducted a retrospective cohort study of patients with repaired mandible fractures. The independent variable was the time span from injury to surgical repair. The primary outcome variable was the rate of complications measured postoperatively dur... περισσότερα »
Custom-Machined Miniplates and Bone-Supported Guides for Orthognathic Surgery: A New Surgical Procedure
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Joan Brunso Casellas., Maria Franco Echevarria., Thomas Constantinescu., Luis Barbier Herrero., Joseba Andoni Santamaría Zuazua., Julio Alvarez Amézaga. BackgroundSeveral surgical strategies exist to improve accuracy in orthognathic surgery (OGS), but ideal planning and treatment have yet to be described. The purpose of this study is to present and assess the accuracy of a virtual orthognathic positioning system (OPS), based on the use of bone-supported guides for placeme...περισσότερα »
Effects of a community-oriented obesity prevention programme on indicators of body fatness in preschool and primary school children: main results from the IDEFICS study
BACKGROUND/OBJECTIVES: Childhood obesity is a major public health concern but evidence-based approaches to tackle this epidemic sustainably are still lacking. The Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) study investigated the aetiology of childhood obesity and developed a primary prevention programme. Here, we report on the effects of the IDEFICS intervention on indicators of body fatness. SUBJECTS/METHODS: The intervention modules addressed the community, school and parental level, focusing on diet, physical... περισσότερα »
Belgische VIP’s brengen ISA verder
Draagvlak creëren voor ISA. Dat was een belangrijke doelstelling van het organiseren van demonstratieritten met een ISA-auto voor belangrijke Belgen én van een ISA-proef in Gent. Ook aan de Gentse proef deden VIP's mee, zoals de Gentse burgemeester en de rector van de universiteit. Door deze aanpak kreeg ISA veel publiciteit en groeide de bekendheid. Een bericht uit de Belgische ISA-stad. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1JeRbwp via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://if... περισσότερα »
A novel case presenting with an unusual ureteral diverticular lesion similar to adenomyomatous hyperplasia of the gallbladder
We present the first case of an unusual ureteral diverticular lesion demonstrating similarities to adenomyomatous hyperplasia of the gallbladder. A 68-year-old asymptomatic Japanese man with high prostate-specific antigen levels was clinically evaluated. Left hydronephrosis and benign prostatic hyperplasia were detected. A bilateral retrograde pyelogram revealed that the upper and middle portions of the left ureter exhibited an irregular narrow lumen and some pooling of contrast material, which was compatible with ureteral pseudodiverticulosis. Although no malignant cells were see...περισσότερα »
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma
Summary There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein–Barr virus (EBV). In this study we found that restoration of miR-1 dramatically inhibited cell invasion *in vitro*, together with tumour growth and metastasis *in vivo*. Importantly, we found that LMP1, an Epstein–Barr virus (EBV)-associated protein, suppressed miR-1 expression. Furthermo... περισσότερα »
Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP-activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β-cell function in islets from rats subjected to CR for 21 days. Eight-week-old male rats were distributed into a control (CTL) group that was fed an isocaloric diet *ad libitum* or a CR group that received 60% of the food consumed by the CTL group. From days 18–21, CTL and CR rats were treated with sense (CTLS and CRS) or antisense (CTLAS and CRAS) AMPKα2 oligonucleotides. Caloric restri... περισσότερα »
Characterization of lesion formation in marmosets following inhalational challenge with different strains of Burkholderia pseudomallei
Summary The marmoset model of melioidosis was used to explore whether there was any difference in the disease presentation and/or the lesion formation following inhalational challenge with one of four strains of *Burkholderia pseudomallei* (K96243, 1026b, HBPUB10303a and HBPUB10134a). Marmosets were challenged with a range of bacterial doses and bacterial load, histological and physiological features were determined temporally following lethal disease. Melioidosis presented as an acute, febrile disease with bacteraemia, bacterial dissemination, necrotizing hepatitis, splenitis and ... περισσότερα »
Multiple pathways regulate Cten in colorectal cancer without a Tensin switch
Summary *CTEN/TNS4* is a member of the Tensin gene family. It localizes to focal adhesions and induces cell motility. The mechanisms regulating Cten expression are unclear although we have shown regulation by Kras in the colon and pancreas. In normal mammary cell lines, it is reportedly upregulated by epidermal growth factor receptor (EGFR) and STAT3 signalling and upregulation is accompanied by downregulation of Tensin 3 (Tensin switch). In this study, we investigated the roles of EGFR and STAT3 signalling in the regulation of Cten in colorectal cancer (CRC). In addition, we inve... περισσότερα »
Treatment with Mesna and n-3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats
Summary Oxidative damage is a central feature of ulcerative colitis. Here, we tested whether the antioxidant Mesna, when administered alone or in combination with n-3 polyunsaturated fatty acids (n-3 PUFAs), affects the outcome of dextran sodium sulphate (DSS)-induced ulcerative colitis in rats. After the induction of colitis, DSS-treated rats were further treated orally (p.o), intraperitoneally (i.p) or intrarectally (i.r) for either 7 or 14 days with Mesna, n-3 PUFAs or both. Rats were euthanized at the end of each treatment period. Clinical disease activity index was recorded t... περισσότερα »
Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-κB-dependent inflammatory/MMP-9 pathway
Summary Acute lung injury (ALI) is one of the most serious complications in traumatic patients and is an important part of multiple organ dysfunction syndrome (MODS). Recombinant human brain natriuretic peptide (rhBNP) is a peptide with a wide range of biological activity. In this study, we investigated local changes in oxidative stress and the NF-κB-dependent matrix metalloproteinase-9 (MMP-9) pathway in rats with trauma/haemorrhagic shock (TH/S)-induced ALI and evaluated the effects of pretreatment with rhBNP. Forty-eight rats were randomly divided into four groups: sham operati... περισσότερα »
Increased thyroid hormone activation accompanies the formation of thyroid hormone dependent negative feedback in developing chicken hypothalamus
Endocrinology, Early Release. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Zy77f2 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1U92Ih3 via IFTTT
Cadmium induces mucin 8 expression via Toll-like receptor 4–mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells
Background Inhalation of cadmium can lead to development of inflammatory airway diseases such as acute pulmonary edema and chronic obstructive pulmonary disease. In inflammatory airway diseases, expression of mucins is increased, which leads to increased morbidity and mortality of the affected patients. However, no study on the effect of cadmium on expression of mucin genes in airway epithelial cells has been reported. Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of cadmium on expression of mucin genes in human airway epithe...περισσότερα »
Timing of endoscopic surgical decompression in traumatic optic neuropathy: a systematic review of the literature
Background Traumatic optic neuropathy (TON) represents a rare but devastating complication of closed head injuries. No accepted guidelines are available for medical and surgical management algorithms. A systematic review of the literature was performed to determine the optimal timing and candidacy for endoscopic surgical intervention. Methods A systematic review of multiple databases was performed including Medline-Ovid, EMBASE, and PubMed. Data was extracted and patients stratified based on surgical delay from trauma (≤3 days, >3 days, ≤7 days, or >7 days) as well as preoperativ...περισσότερα »
Lovely image of a Tornwaldt’s cyst
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Ni11bv via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StwcbW via IFTTT
The Waterless Portable Private Toilet: An Innovative Sanitation Solution in Disaster Zones
Research Articles Yongkyun Kim, Shervin Hashemi, Mooyoung Han, Tschungil Kim, Hong-Gyoo Sohn Disaster Medicine and Public Health Preparedness, FirstView Article(s), 5 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Wq6VhX via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuC9V via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20bhho0 v... περισσότερα »
Engaging the Diaspora in Response to the 2014 Fogo Volcano Eruption in Cape Verde
Letter Elena Savoia, Leesa Lin, Noah Klein, Alberto Montrond Disaster Medicine and Public Health Preparedness, FirstView Article(s), 2 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/23bR7Ea via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuBTx via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZJsvDt via IFTTT
CeO2-covered nanofiber for highly efficient removal of phosphorus from aqueous solution
Publication date: 15 April 2016 *Source:*Journal of Hazardous Materials, Volume 307 Author(s): Young Gun Ko, Taegu Do, Youngsang Chun, Choong Hyun Kim, Ung Su Choi, Jae-Yong Kim The lowering phosphorus concentration of lakes or rivers using adsorbents has been considered to be the most effective way to prevent water eutrophication. However, the development of an adsorbent is still challenging because conventional adsorbents have not shown a sufficient phosphorus adsorption capacity (0.3–2.0mmol/g) to treat industrial, agricultural or domestic wastewater at a large scale. Herein, a n...περισσότερα »
Reporting on Adverse Clinical Events
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23bUbzW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuAig via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZJsvDr via IFTTT
Mouse is the new woman? Translational research in reproductive immunology
Abstract In an outbred mating typical of human reproduction, the embryo and feto-placental unit express paternal antigens to which the mother's immune system can react. However, the embryo and feto-placental unit can engineer the maternal immune defense system towards helpful rather than harmful reactions. Indeed, this begins with the prospective mother's exposure to paternal seminal plasma. In this review, the pregnancy complications of implantation failure (infertility), recurrent spontaneous abortion, pre-eclampsia and intrauterine growth restriction, and premature labor are ex... περισσότερα »
Rheumatic diseases should be actively treated in pregnancy, new guidelines say
New guidelines on prescribing anti-rheumatic drugs for pregnant and breastfeeding women, published in the Rheumatology journal, warn against withdrawing potentially beneficial treatment and recommend… [image: recent?d=yIl2AUoC8zA] [image: recent?d=dnMXMwOfBR0] [image: recent?i=W36IswyMNdI:bWtJVlH1unA:V_sGLiP] [image: recent?d=qj6IDK7rITs] [image: recent?i=W36IswyMNdI:bWtJVlH1unA:gIN9vFw] [image: recent?d=l6gmwiTKsz0] [image: recent?d=7Q72WNTAKBA] [image: recent?i=W36IswyMNdI:bWtJVlH1unA:F7zBnMy] [image: recent?i=W36IswyMNdI:bWtJVlH1unA:-BTjWOF] [image: 1Rxbt6J] from #ORL-Alexandro... περισσότερα »
Real acupuncture for hot flushes is no better than sham, study finds
Acupuncture, performed by a practitioner of Chinese medicine, was found to be no better at reducing menopausal hot flushes than sham acupuncture, in which needles do not penetrate the skin, in a… [image: recent?d=yIl2AUoC8zA] [image: recent?d=dnMXMwOfBR0] [image: recent?i=PcvRZzA-eDw:gqLGj7ry9V0:V_sGLiP] [image: recent?d=qj6IDK7rITs] [image: recent?i=PcvRZzA-eDw:gqLGj7ry9V0:gIN9vFw] [image: recent?d=l6gmwiTKsz0] [image: recent?d=7Q72WNTAKBA] [image: recent?i=PcvRZzA-eDw:gqLGj7ry9V0:F7zBnMy] [image: recent?i=PcvRZzA-eDw:gqLGj7ry9V0:-BTjWOF] [image: 1PCIo3M] from #ORL-AlexandrosSfak... περισσότερα »
Vorteile durch minimalinvasiven Zugang in der Klappenchirurgie
Aortenklappenersatz Minimalinvasive Zugänge für Herzklappenoperationen werden zwar zunehmend benutzt, dennoch ist speziell beim Aortenklappenersatz dieser Zugang noch immer die Ausnahme und wird auch für die isolierte Mitralklappenoperation in weniger als der Hälfte der Fälle angewandt. Dies betrifft aber auch nur ausgesuchte Zentren mit hohen Fallzahlen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23bU9s3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KoGJxd via IFTTT from #Med Bl... περισσότερα »
Modified measles versus rubella versus atypical measles: One and same thing
*Surender Nikhil Gupta, Naveen Gupta, Shivani Gupta* Journal of Family Medicine and Primary Care 2015 4(4):566-569 Introduction: In outbreak settings, more than one virus may be infecting the given population. In twin or triple outbreak of measles, German measles (rubella), and varicella in highly immunized hilly areas, maximal number of the case patients in all the hilly villages belonged to the older age group. It suggested an obvious shift to the higher age group, warranting second dose opportunity in such case scenario. The clinical presentations of viral diseases are too simi... περισσότερα »
The Waterless Portable Private Toilet: An Innovative Sanitation Solution in Disaster Zones
Research Articles Yongkyun Kim, Shervin Hashemi, Mooyoung Han, Tschungil Kim, Hong-Gyoo Sohn Disaster Medicine and Public Health Preparedness, FirstView Article(s), 5 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Wq6VhX via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuC9V via IFTTT
Engaging the Diaspora in Response to the 2014 Fogo Volcano Eruption in Cape Verde
Letter Elena Savoia, Leesa Lin, Noah Klein, Alberto Montrond Disaster Medicine and Public Health Preparedness, FirstView Article(s), 2 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/23bR7Ea via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuBTx via IFTTT
CeO2-covered nanofiber for highly efficient removal of phosphorus from aqueous solution
Publication date: 15 April 2016 *Source:*Journal of Hazardous Materials, Volume 307 Author(s): Young Gun Ko, Taegu Do, Youngsang Chun, Choong Hyun Kim, Ung Su Choi, Jae-Yong Kim The lowering phosphorus concentration of lakes or rivers using adsorbents has been considered to be the most effective way to prevent water eutrophication. However, the development of an adsorbent is still challenging because conventional adsorbents have not shown a sufficient phosphorus adsorption capacity (0.3–2.0mmol/g) to treat industrial, agricultural or domestic wastewater at a large scale. Herein, a n...περισσότερα »
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment: Abstract Background Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on… Continue reading 177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
Winifred E Heller
Winifred E Heller, also known as Winifred E Hunter, was a senior partner at practices in Dagenham and Romford, in Essex. She was a popular, old fashioned family doctor. She never refused a home visit… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PnT2Ls via IFTTT
Eyelid fat grafting: indications, operative technique and complications; a systematic review
Publication date: Available online 18 January 2016 Source:Journal of Cranio-Maxillofacial Surgery Author(s): Elodie Boureaux, Benoit Chaput, Sahar Bannani, Christian Herlin, Antoine De Runz, Raphael Carloni, Bruno Mortemousque, Frederic Mouriaux, Eric Watier, Nicolas Bertheuil IntroductionMany recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series.… Continue reading Eyelid fat grafting: indications, operative technique and complications; a systematic review
Laurence Langdon
bmj;352/jan19_9/i286/FIG1F1fig1Laurence Langdon (“Laurie”) served in the Royal Naval Volunteer Reserve on minesweepers before reading medicine at Bart’s. Appointed consultant in the Southampton and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1T1bb7J via IFTTT
Vitiligo
Zusammenfassung Hintergrund Die Vitiligo ist eine chronische Erkrankung der Haut mit Pigmentverlust umschriebener Areale infolge morphologischer und funktioneller Schädigung der Melanozyten. Ergebnisse Es gibt einen internationalen Konsensus über die Klassifikation mit Unterscheidung der nichtsegmentalen von der segmentalen Vitiligo. Die Einschränkung der Lebensqualität ist erheblich und von ethnischen und soziokulturellen Faktoren abhängig. Es gibt neue Erkenntnisse… Continue reading Vitiligo
Toxins, Vol. 8, Pages 27: Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice
Oxaliplatin, a chemotherapy drug used to treat colorectal cancer, induces specific sensory neurotoxicity signs that are aggravated by cold and mechanical stimuli. Here we examined the preventive effects of Bee Venom (BV) derived phospholipase A2 (bvPLA2) on oxaliplatin-induced neuropathic pain in mice and its immunological mechanism. The cold and mechanical allodynia signs were evaluated by… Continue reading Toxins, Vol. 8, Pages 27: Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice
David Oliver: Rehabilitation is part of medicine
I spoke recently at a conference on how future hospital models must adapt to older people’s needs. Conversation afterwards turned to doctors’ careers and what might make acute and general internal… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1T1baRj via IFTTT
Three-dimensional analysis of maxillary stability after Le Fort I osteotomy using hydroxyapatite/poly-L-lactide plate
Publication date: Available online 19 January 2016 Source:Journal of Cranio-Maxillofacial Surgery Author(s): Jung Hyun Park, Minkyu Kim, Sang Yoon Kim, Hwi-Dong Jung, Young-Soo Jung PurposeTo evaluate three-dimensional change in maxillary position using biodegradable plates.Material and MethodsA total of 53 patients who underwent orthognathic surgery using biodegradable plates were analyzed retrospectively. The position of maxilla was… Continue reading Three-dimensional analysis of maxillary stability after Le Fort I osteotomy using hydroxyapatite/poly-L-lactide plate
Mercedes GLC F-Cell arriverà il prossimo anno – MotoriBlog.net (Blog)
MotoriBlog.net (Blog) Mercedes GLC F-Cell arriverà il prossimo anno MotoriBlog.net (Blog) Da un’intervista ad Autocar, il Prof. Dr. Thomas Weber, capo del settore ricerca e sviluppo di Mercedes, ha detto che » La GLC F-Cell sarà dotata della più aggiornata tecnologia delle celle a combustibile e beneficierà dei più recenti progressi nel … and more… Continue reading Mercedes GLC F-Cell arriverà il prossimo anno – MotoriBlog.net (Blog)
Sen start av tilleggsbehandling ved tykktarmskreft
Retningslinjene sier at behandling med kjemoterapi skal igangsettes 4–6 uker etter kirurgisk inngrep. En ny studie viser at halvparten av norske pasienter får denne behandlingen innen seksukersfristen. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Jf7skQ via IFTTT
Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis: Abstract The aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined the correlation of TRPM7 expression with cell growth and proliferation, cell cycle, and apoptosis in vitro in NPC cell […]
Macht Lebensstilberatung die Vorsorge-Koloskopie erst komplett?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Darmkrebs-Prävention Der Einfluss einer Vorsorge-Koloskopie auf die Änderung eines ungesunden Lebensstils bezüglich kolorektaler Karzinome ist kurzfristig negativ und langfristig bescheiden. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZJIh13 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ni7JKe via IFTTT
Ist eine Thrombolyse auch unter Plättchenhemmung sicher?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Ischämischer Schlaganfall Erleiden Patienten unter Plättchenhemmern einen ischämischen Schlaganfall, ist das Blutungsrisiko bei einer rt-PA-Lyse nur minimal erhöht. Dagegen scheint die Prognose im Vergleich zu Betroffenen ohne ASS und Clopidogrel etwas besser zu sein. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U9cZtB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from […]
Piwi-interacting RNAs in cancer: emerging functions and clinical utility
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Piwi-interacting RNAs in cancer: emerging functions and clinical utility: Abstract PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact with PIWI proteins, another member of the Argonaute family, and function primarily in the nucleus. […]
Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type: Abstract Extranodal natural killer/T cell lymphoma (ENKTL) is a rare subtype of lymphoma. Recurrent mutations in the JAK-STAT pathway, recently reported in ENKTL cases, are interesting in terms of both pathogenesis and inhibitor therapy. However, the frequencies of these mutations are low and variable among reports, […]
EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum: Abstract Mitochondrial aminoacyl tRNA synthetases are essential for organelle protein synthesis. Genetic defects affecting the function of these enzymes may cause pediatric mitochondrial disease. Here, we report on a child with fatal neonatal lactic acidosis and recurrent hypoglycemia caused by mutations […]
Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma: Abstract Oral squamous cell carcinoma (OSCC) accounts for 90 % of malignant lesions of oral cavity. The study assessed the potential of Cyfra 21-1 as a tumor marker in OSCC. The study included 50 patients of OSCC […]
Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Effect of Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status in Obese Patients with Treated Hypertension: Abstract The effects of Spirulina maxima supplementation on calcium, magnesium, iron, and zinc status were studied in a double-blind placebo-controlled trial of 50 obese subjects with treated hypertension, each randomized to receive 2 g of spirulina or […]
Pharmacokinetic interaction between pazopanib and cisplatin regimen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Pharmacokinetic interaction between pazopanib and cisplatin regimen: Abstract Purpose A phase I study combining daily oral pazopanib and cisplatin (given iv every 3 weeks) was performed in order to determine the maximum tolerated dose of both drugs in combination. Pharmacokinetic interactions were evaluated. Methods Plasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients […]
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment: Abstract Background Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on […]
STK 11 gene testing in individuals with oral pigmentation
The role of STK 11 gene testing in individuals with oral pigmentation: Abstract Peutz–Jeghers syndrome (PJS) is a rare, autosomal dominant condition characterised by mucocutaneous pigmented lesions, gastrointestinal polyposis and a significant risk of cancer. Laugier–Hunziker syndrome (LHS) is a benign condition with similar dermatological features, but with no systemic complications. *STK 11* gene testing allows clinicians to differentiate between these two disorders. This case report compares the dermatological similarities in four individuals with PJS or LHS and illustrates the ... περισσότερα »
Oral pigmentation : Peutz–Jeghers syndrome (PJS),Laugier–Hunziker syndrome (LHS)
The role of STK 11 gene testing in individuals with oral pigmentation: Abstract Peutz–Jeghers syndrome (PJS) is a rare, autosomal dominant condition characterised by mucocutaneous pigmented lesions, gastrointestinal polyposis and a significant risk of cancer. Laugier–Hunziker syndrome (LHS) is a benign condition with similar dermatological features, but with no systemic complications. *STK 11* gene testing allows clinicians to differentiate between these two disorders. This case report compares the dermatological similarities in four individuals with PJS or LHS and illustrates ... περισσότερα »
Granulomatous arthritis, skin eruptions and uveitis, which occur in the absence of lung involvement
Granulomatous skin involvement in a patient with an unusual NOD2 mutation: Abstract Blau syndrome is a rare disorder that is classically characterised by granulomatous arthritis, skin eruptions and uveitis, which occur in the absence of lung involvement. Blau syndrome has been linked to encoding mutations in the *NOD-2* gene and is inherited in an autosomal dominant form. The most commonly observed mutations are missense substitutions affecting the arginine residue at position 334. The rare E600A mutation has been described as causing uveitis without skin involvement. Our patient is...περισσότερα »
Multiple basal cell carcinoma (BCC), keratocystic odontogenic tumours in the jaws and bifid ribs
Confocal and dermoscopic features of basal cell carcinoma in Gorlin–Goltz syndrome: A case report: Abstract Gorlin–Goltz (GS) syndrome is an autosomal dominant disease linked to a mutation in the *PTCH* gene. Major criteria include the onset of multiple basal cell carcinoma (BCC), keratocystic odontogenic tumours in the jaws and bifid ribs. Dermoscopy and reflectance confocal microscopy represent imaging tools that are able to increase the diagnostic accuracy of skin cancer in a totally noninvasive manner, without performing punch biopsies. Here we present a case of a young woman i...περισσότερα »
Trends in sun-protection behaviour
Trends in sun-protection behaviour in Australian adults 2007–2012: Abstract Background Almost all skin cancers are the result of overexposure to UV radiation and could be prevented by adhering to a number of simple behavioural guidelines to minimise exposure to the sun. The present study examined trends in sun-protection behaviour among adults living in Western Australia, a region with high levels of UV radiation. Methods During five summers from 2008 to 2012, 2076 Western Australian adults participated in annual, cross-sectional telephone surveys that assessed how often they engage...περισσότερα »
Solitary plaques,solitary nodules,sinuses,crypts,verrucous plaques and discharge, usually on sun-exposed skin
Heterogeneity of blastomycosis-like pyoderma: A selection of cases from the last 35 years: Abstract Blastomycosis-like pyoderma is a form of pyoderma with variable clinical findings and histopathological features. We present a case series of 39 patients collected over a 35-year period to demonstrate its clinical features and histological findings. The most common clinical presentations found were solitary plaques, solitary nodules, sinuses, crypts, verrucous plaques and discharge, usually on sun-exposed skin. The most common histopathological findings were chronic granulomatous inf... περισσότερα »
A novel case presenting with an unusual ureteral diverticular lesion similar to adenomyomatous hyperplasia of the gallbladder
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
We present the first case of an unusual ureteral diverticular lesion demonstrating similarities to adenomyomatous hyperplasia of the gallbladder. A 68-year-old asymptomatic Japanese man with high prostate-specific antigen levels was clinically evaluated. Left hydronephrosis and benign prostatic hyperplasia were detected. A bilateral retrograde pyelogram revealed that the upper and middle portions of the left ureter […]
Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP-activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β-cell function in islets from rats subjected to CR for 21 days. Eight-week-old male rats were distributed into a control (CTL) group that was fed an […]
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein–Barr virus (EBV). In this study we found that restoration of miR-1 dramatically inhibited cell invasion in […]
Characterization of lesion formation in marmosets following inhalational challenge with different strains of Burkholderia pseudomallei
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary The marmoset model of melioidosis was used to explore whether there was any difference in the disease presentation and/or the lesion formation following inhalational challenge with one of four strains of Burkholderia pseudomallei (K96243, 1026b, HBPUB10303a and HBPUB10134a). Marmosets were challenged with a range of bacterial doses and bacterial load, histological and physiological features […]
Treatment with Mesna and n-3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary Oxidative damage is a central feature of ulcerative colitis. Here, we tested whether the antioxidant Mesna, when administered alone or in combination with n-3 polyunsaturated fatty acids (n-3 PUFAs), affects the outcome of dextran sodium sulphate (DSS)-induced ulcerative colitis in rats. After the induction of colitis, DSS-treated rats were further treated orally (p.o), intraperitoneally […]
Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-κB-dependent inflammatory/MMP-9 pathway
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary Acute lung injury (ALI) is one of the most serious complications in traumatic patients and is an important part of multiple organ dysfunction syndrome (MODS). Recombinant human brain natriuretic peptide (rhBNP) is a peptide with a wide range of biological activity. In this study, we investigated local changes in oxidative stress and the NF-κB-dependent […]
Multiple pathways regulate Cten in colorectal cancer without a Tensin switch
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Summary CTEN/TNS4 is a member of the Tensin gene family. It localizes to focal adhesions and induces cell motility. The mechanisms regulating Cten expression are unclear although we have shown regulation by Kras in the colon and pancreas. In normal mammary cell lines, it is reportedly upregulated by epidermal growth factor receptor (EGFR) and STAT3 […]
Increased thyroid hormone activation accompanies the formation of thyroid hormone dependent negative feedback in developing chicken hypothalamus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Endocrinology, Early Release. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Zy77f2 via IFTTT
Cadmium induces mucin 8 expression via Toll-like receptor 4–mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
Background Inhalation of cadmium can lead to development of inflammatory airway diseases such as acute pulmonary edema and chronic obstructive pulmonary disease. In inflammatory airway diseases, expression of mucins is increased, which leads to increased morbidity and mortality of the affected patients. However, no study on the effect of cadmium on expression of mucin genes […]
Lovely image of a Tornwaldt’s cyst
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 9 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Ni11bv via IFTTT
The Effectiveness of Written Action Plans in Atopic Dermatitis
The Effectiveness of Written Action Plans in Atopic Dermatitis: Abstract Atopic dermatitis (AD) is a chronic dermatosis requiring a stepwise and dynamic approach to management. The use of written action plans has been shown to improve outcomes in other chronic diseases that require a similar incremental approach. A systematic review was performed to evaluate the effect of a written eczema action plan (EAP) in AD management and to identify characteristics of effective action plans in children with eczema. Only two trials were identified as eligible, which highlights the need for mor...περισσότερα »
Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study
Clinical Efficacy of Herbal Medicine for Pediatric Lymphatic Malformations: A Pilot Study: Abstract Background Lymphatic malformations (LMs) are congenital malformations of the lymphatic system that commonly affect the head and neck region and cause marked cosmetic and functional complications. In this pilot study, we present eight children with LMs treated using an herbal medicine for this indication. Methods Between January 2009 and May 2014, eight children (four boys, four girls) with LMs were treated using oral administration of an herbal medicine, Eppikajyutsuto (TJ-28; Tsumur... περισσότερα »
Diagnosis of an additional in situ melanoma does not influence survival for patients with a single invasive melanoma: A registry-based follow-up study
Diagnosis of an additional in situ melanoma does not influence survival for patients with a single invasive melanoma: A registry-based follow-up study: Abstract Using a large (*N*= 25 493) population-based cohort from Queensland, Australia, we compared melanoma survival among cases with a single invasive melanoma only against those who also had a diagnosis of a single *in situ* melanoma. After adjustment for sex, age, body site, clinicopathological subtype, thickness and ulceration, it was found that there was no difference (*P* = 0.99) in 10-year melanoma-specific mortality followi...περισσότερα »
Senile lower lid entropion successfully treated with botulinum toxin A
Senile lower lid entropion successfully treated with botulinum toxin A: Summary Background Spasmodic senile entropion (SE) is characterized by the inward turning of the eyelid. SE typically occurs spontaneously, but sometimes after ocular surgery. As of today, it is still lacking a gold standard technique. Aims To report the results of 11 cases of involutional entropion of the lower lid successfully treated with an injection of botulinum toxin, to evaluate the clinical results, and to document the duration of relief. Methods Eleven patients with senile entropion were treated with abob... περισσότερα »
Medicinal and cosmetics soap production from Jatropha oil
Medicinal and cosmetics soap production from Jatropha oil: Summary Soap is the most useful things which we use our everyday life in various cleansing and cosmetics purposes. Jatropha oil is nonedible oil which has more benefits to soap making. It has also cosmetics and medicinal properties. But the presence of toxic Phorbol esters in Jatropha oil is the main constrains to use it. So it is necessary to search a more suitable method for detoxifying the Jatropha oil before the use as the main ingredient of soap production. This review implies a more suitable method for removing phorbo... περισσότερα »
Water-based correction fluid is a useful skin marker for determination of the tumor margin of basal cell carcinoma under high-frequency ultrasound
Water-based correction fluid is a useful skin marker for determination of the tumor margin of basal cell carcinoma under high-frequency ultrasound: Abstract We propose a new method to determine the appropriate preoperative surgical margin of basal cell carcinoma (BCC) by using water-based correction fluid as a skin marker showing the tumor position on the skin under high-frequency ultrasound (HFUS). After a provisional evaluation by dermoscopy, an approximately 2-mm dot of water-based correction fluid is applied to the tumor margin. The ultrasound waves are blocked by the dot of co... περισσότερα »
Biomarkers and Personalized Medicine
Biomarkers and Personalized Medicine: Current Status and Further Perspectives with Special Focus on Dermatology: Abstract Biomarkers are of high and further increasing importance in medicine, particularly in the realm of ‘personalized medicine’. They are valuable for predicting prognosis and dose selection. Moreover they may be helpful in detecting therapeutic and adverse responses, and in patient stratification based on efficacy or safety prediction. Thus, biomarkers are essential tools for the selection of appropriate patients for treatment with certain drugs and enable personali... περισσότερα »
Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen
Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen: Abstract BackgroundCetuximab, in combination with platinum chemotherapy plus 5-fluoruracil (5-FU), is approved for the first-line treatment of recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN). Cetuximab manufactured by ImClone (US commercial cetuximab) potentially results in higher systemic exposures than cetuximab manufactured by Boehringe... περισσότερα »
Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma
Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma: Abstract BackgroundBoth tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progression of oral squamous cell carcinoma (OSCC) remains undefined. ResultsHere we detected the expression of macrophages markers CD68 and CD163, epithelial marker E-cadherin and mesen... περισσότερα »
Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant
Pure Erythroid Leukemia Mimicking Ewing Sarcoma/Primitive Neuroectodermal Tumor in an Infant: Pure erythroid leukemia (PEL) is a rare type of acute myeloid leukemia (AML) with a very aggressive clinical course. Presentation as a myeloid/erythroid sarcoma is exceedingly rare. We describe an infantile PEL presenting as a multifocal myeloid sarcoma, clinically and pathologically mimicking Ewing sarcoma/PNET family of tumors. The patient died 8 weeks after the initial presentation due to widespread disease. Our case shows that PEL needs to be considered in the differential diagnosis of...περισσότερα »
High-Risk Neuroblastoma Without Lead-Lined Rooms
Feasibility of Administering High-Dose 131I–MIBG Therapy to Children with High-Risk Neuroblastoma Without Lead-Lined Rooms: [image: cover.gif?v=1&s=aca24c650f05e7b82a6847eb] Background Although 131I–metaiodobenzylguanidine (131I–MIBG) therapy is increasingly used for children with high-risk neuroblastoma, a paucity of lead-lined rooms limits its wider use. We implemented radiation safety procedures to comply with New York City Department of Health and Mental Hygiene regulations for therapeutic radioisotopes and administered 131I–MIBG using rolling lead shields. Procedure Patient... περισσότερα »
Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation
Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation: AbstractThe present study aimed to evaluate the role of Hedgehog (Hh) molecule expression in association with the clinical aspects of oral squamous cell carcinoma (OSCC), as well as angiogenesis and CD163+ macrophages. Twenty-eight cases of OSCC, nine cases of tumor-free resection margins (TM), and four cases of non-neoplastic oral mucosa (NNM) were submitted to immunohistochemistry to detect proteins Sonic Hedgehog (SHH), Indian Hedgehog (IHH), GLI1, CD163, a... περισσότερα »
Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis
Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis: AbstractThe aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined the correlation of TRPM7 expression with cell growth and proliferation, cell cycle, and apoptosis in vitro in NPC cell lines and NPC tumorigenesis in mice by conducting experiments in mice and by further analyzing the tumor volume and growth. We further explored to see whether there is any positive correlation with the TRPM7 ... περισσότερα »
The Role of Narrow Band Imaging in Head and Neck Cancers
The Role of Narrow Band Imaging in Head and Neck Cancers: AbstractEarly diagnosis of malignant tumors in the head and neck region is very difficult. Therefore, endoscopic systems with narrow band imaging (NBI), which enhances image contrast, have an important clinical value in detecting superficial mucosal lesions. In particular, highlighting of the intraepithelial microvasculature helps determine the nature of the lesion. This new image-enhanced technology already has proven effective in the early diagnosis of head and neck squamous cell carcinoma, including laryngeal, hypopharyng...περισσότερα »
Pendulum swings from hypo- to hyperthyroidism: thyrotoxicosis after severe hypothyroidism following neck irradiation in a patient with a history of Hodgkin’s lymphoma
Pendulum swings from hypo- to hyperthyroidism: thyrotoxicosis after severe hypothyroidism following neck irradiation in a patient with a history of Hodgkin’s lymphoma: Abstract BackgroundA change in a thyrometabolic state from severe hypothyroidism to thyrotoxicosis is very uncommon, but possible in some circumstances. Case presentationA 27-year old female presented with clinical and biochemical thyrotoxicosis with a previous history chemo- and radiotherapy (including the neck region) for a Hodgkin’s lymphoma (at the age of 18). At the age of 20 this was followed by severe hypo... περισσότερα »
Cancer of the Esophagus
*Cancer of the Esophagus **http://pathology2.jhu.edu/beweb/cancer.cfm*The presence of Barrett's esophagus is associated with increased risk of developing an invasive cancer (adenocarcinoma). Columnar epithelial dysplasia as seen in Barrett's esophagus is a premalignant lesion for adenocarcinoma. Adenocarcinoma does not develop "out of the blue". Instead, adenocarcinoma in Barrett's esophagus develops in a sequence of changes, from nondysplastic (metaplastic) columnar epithelium, through low-grade and then high-grade dysplasia (preancerous change detected under the microscope) and fi... περισσότερα »
Advances in the Management of Gastric and Gastroesophageal Cancers
Advances in the Management of Gastric and Gastroesophageal Cancers: AbstractManagement of gastric and gastroesophageal cancers is a complex, evolving paradigm. Involvement of multimodality specialties is the key. In gastric cancer, data are conflicting with regard to the specific roles of surgery, chemotherapy, and radiation, particularly between Asian and Western studies. However, current ongoing phase III trials will further elucidate the optimal treatment for this heterogeneous disease. For resectable gastroesophageal junction (GEJ) tumors, the publication of a landmark study in...περισσότερα »
β-Glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses
β-Glucan restores tumor-educated dendritic cell maturation to enhance antitumor immune responses: Abstract Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendritic cells (TEDCs) involved in the tolerance induction have attracted much attention recently. In this study, we investigated the effect of β-glucan on TEDCs and f...περισσότερα »
Inflammation as a cause of Venous Thromboembolism
Inflammation as a cause of Venous Thromboembolism via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 16 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Amene Saghazadeh, Nima Rezaei Inflammatory markers are highly amenable to appraise and adjust and could already serve as a diagnostic indicator and also as a predictor of prognosis over the management of many health problems. Inflammation is implicated in venous thromboembolism (VTE). However there is still an intense curiosity about whether it is a cause or only a conseq... περισσότερα »
Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk
: a review of the evidence via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 15 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Paule Latino-Martel, Vanessa Cottet, Nathalie Druesne-Pecollo, Fabrice H.F. Pierre, Marina Touillaud, Mathilde Touvier, Marie-Paule Vasson, Mélanie Deschasaux, Julie Le Merdy, Emilie Barrandon, Raphaëlle Ancellin PurposePrevention is a priority in the fight against cancers, especially nutritional prevention. To update the levels of evidence of relationships between 10 nutritional factors and c... περισσότερα »
Predictors of Trigeminal Neuropathy after Radiosurgery for Vestibular Schwannomas
Predictors of Trigeminal Neuropathy after Radiosurgery for Vestibular Schwannomas via International Journal of Radiation Oncology*Biology*Physics Publication date: Available online 15 January 2016 *Source:*International Journal of Radiation Oncology*Biology*Physics Author(s): Suhan Senova, Mourad Aggad, Jean-Louis Golmard, Dominique Hasboun, Ioannis Lamproglou, Catherine Jenny, Philippe Cornu, Jean-Jacques Mazeron, Charles A. Valery ObjectivesThe incidence of trigeminal neuropathy (TN) after vestibular schwannomas (VS) radiosurgery (RS) varies between 0 and 29 % across recent series. T... περισσότερα »
Piwi-interacting RNAs in cancer: emerging functions and clinical utility
Piwi-interacting RNAs in cancer: emerging functions and clinical utility: AbstractPIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact with PIWI proteins, another member of the Argonaute family, and function primarily in the nucleus. There, they are involved in the epigenetic silencing of transposable elements in addition to the transcriptional regulation of genes. It has recently been demonstrated that piRNAs are also expressed a... περισσότερα »
Macht Lebensstilberatung die Vorsorge-Koloskopie erst komplett?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Darmkrebs-Prävention Der Einfluss einer Vorsorge-Koloskopie auf die Änderung eines ungesunden Lebensstils bezüglich kolorektaler Karzinome ist kurzfristig negativ und langfristig bescheiden. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ZJIh13 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Ist eine Thrombolyse auch unter Plättchenhemmung sicher?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Ischämischer Schlaganfall Erleiden Patienten unter Plättchenhemmern einen ischämischen Schlaganfall, ist das Blutungsrisiko bei einer rt-PA-Lyse nur minimal erhöht. Dagegen scheint die Prognose im Vergleich zu Betroffenen ohne ASS und Clopidogrel etwas besser zu sein. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U9cZtB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Toxins, Vol. 8, Pages 27: Preventive Effects of Bee Venom Derived Phospholipase A2 on Oxaliplatin-Induced Neuropathic Pain in Mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Oxaliplatin, a chemotherapy drug used to treat colorectal cancer, induces specific sensory neurotoxicity signs that are aggravated by cold and mechanical stimuli. Here we examined the preventive effects of Bee Venom (BV) derived phospholipase A2 (bvPLA2) on oxaliplatin-induced neuropathic pain in mice and its immunological mechanism. The cold and mechanical allodynia signs were evaluated by […]
Thwarting abnormal neural development with a new mutation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Researchers at the RIKEN Brain Science Institute in Japan have discovered how to reverse the abnormal axonal development characteristic of CFEOM3, a congenital disease that affects the muscles that… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nvgpwr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Pharmaceuticals, Vol. 9, Pages 4: Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel anti-leukemic chemotherapeutics with potential applications in the treatment of acute myeloid leukemia (AML), a molecularly heterogeneous disease. Dimeric naphthoquinones (BiQs) with the ability to undergo redox cycling and to generate reactive oxygen species (ROS) […]
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 23 δευτερόλεπτα
Publication date: Available online 18 January 2016 Source:Archives des Maladies Professionnelles et de l’Environnement from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RQWoNP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type
Frequent BCOR Aberrations in Extranodal NK/T-Cell Lymphoma, Nasal Type: Abstract Extranodal natural killer/T cell lymphoma (ENKTL) is a rare subtype of lymphoma. Recurrent mutations in the JAK-STAT pathway, recently reported in ENKTL cases, are interesting in terms of both pathogenesis and inhibitor therapy. However, the frequencies of these mutations are low and variable among reports, and other pathognomonic mutations in ENKTL remain to be elucidated. In the present study, we performed targeted capture sequencing of 602 cancer-related genes from 25 frozen ENKTL samples, 11 of whic... περισσότερα »
Timing of Voice Therapy: A Primary Investigation of Voice Outcomes for Surgical Benign Vocal Fold Lesion Patients.
Timing of Voice Therapy: A Primary Investigation of Voice Outcomes for Surgical Benign Vocal Fold Lesion Patients.: *Timing of Voice Therapy: A Primary Investigation of Voice Outcomes for Surgical Benign Vocal Fold Lesion Patients.* J Voice. 2016 Jan 14; Authors: Tang SS, Thibeault SL Abstract OBJECTIVE: This study aims to examine the role of timing of speech-language pathology intervention on outcomes for surgical patients with benign vocal fold lesions as measured by a patient self-reported scale (Voice Handicap Index [VHI]) and objective acoustic measures (jitter %, Dysphonia ...περισσότερα »
Encouragement to Increase the Use of Psychosocial Skills in the Diagnosis and Therapy of Patients With Functional Dysphonia.
Encouragement to Increase the Use of Psychosocial Skills in the Diagnosis and Therapy of Patients With Functional Dysphonia.: *Encouragement to Increase the Use of Psychosocial Skills in the Diagnosis and Therapy of Patients With Functional Dysphonia.* J Voice. 2016 Jan 5; Authors: Kollbrunner J, Seifert E Abstract Clinicians believe that psychosocial factors play a causal role in the etiology of many forms of functional dysphonia (FD). But for decades, all attempts to confirm such causation have failed. This paper aims to show the logic of this failure, to discuss the possibilit... περισσότερα »
Vestibular results after intratympanic gentamicin therapy in disabling Menière's disease.
*Vestibular results after intratympanic gentamicin therapy in disabling Menière's disease.* Eur Arch Otorhinolaryngol. 2016 Jan 16; Authors: Junet P, Karkas A, Dumas G, Quesada JL, Schmerber S Abstract Intratympanic injection of gentamicin is increasingly used in the treatment of unilateral disabling Menière's disease (MD). Several objective functional and subjective tests have been developed to assess the control of vertigo after gentamicin treatment. The aim of this study was to show that subjective results require a vestibular deafferentation as profound as possible, evidence... περισσότερα »
Ultrasound-Guided Pudendal Nerve Block at the Entrance of the Pudendal (Alcock) Canal: Description of Anatomy and Clinical Technique.
*Ultrasound-Guided Pudendal Nerve Block at the Entrance of the Pudendal (Alcock) Canal: Description of Anatomy and Clinical Technique.* Reg Anesth Pain Med. 2016 Jan 16; Authors: Bendtsen TF, Parras T, Moriggl B, Chan V, Lundby L, Buntzen S, Dalgaard K, Brandsborg B, Børglum J Abstract BACKGROUND AND OBJECTIVES: Ultrasound-guided techniques for pudendal nerve block have been described at the level of the ischial spine and transperineally. Theoretically, however, blockade of the pudendal nerve inside Alcock canal with a small local anesthetic volume would minimize the risk of sac... περισσότερα »
Programmed Death Ligand 1 Immunohistochemistry- A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society.
*Programmed Death Ligand 1 Immunohistochemistry- A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society.* Arch Pathol Lab Med. 2016 Jan 18; Authors: Sholl LM, Aisner DL, Allen TC, Beasley MB, Borczuk AC, Cagle PT, Capelozzi V, Dacic S, Hariri L, Kerr KM, Lantuejoul S, Mino-Kenudson M, Raparia K, Rekhtman N, Roy-Chowdhuri S, Thunnissen E, Tsao MS, Yatabe Y Abstract The binding of programmed death ligands 1 and 2 (PD-L1 and PD-L2) to PD-1 blocks T-cell-mediated immune response to tumor. Antibodies that target programmed death 1 (PD-1) will ... περισσότερα »
Folic acid and its photoproducts, 6-formylpterin and pterin-6-carboxylic acid, as generators of reactive oxygen species in skin cells during UVA exposure.
*Folic acid and its photoproducts, 6-formylpterin and pterin-6-carboxylic acid, as generators of reactive oxygen species in skin cells during UVA exposure.* J Photochem Photobiol B. 2016 Jan 6;155:116-121 Authors: Juzeniene A, Grigalavicius M, Ma LW, Juraleviciute M Abstract Folic acid (FA) is the synthetic form of folate (vitamin B9), present in supplements and fortified foods. During ultraviolet (UV) radiation FA is degraded to 6-formylpterin (FPT) and pterin-6-carboxylic acid (PCA) which generate reactive oxygen species (ROS) and may be phototoxic. The aim of the present stud... περισσότερα »
Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation.
*Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation.* Head Neck Pathol. 2016 Jan 16; Authors: Kumar B, Pant B, Kumar V, Negi M Abstract Primary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharynge...περισσότερα »
WHO grade 1 meningioma recurrence: Are location and Simpson grade still relevant?
*WHO grade 1 meningioma recurrence: Are location and Simpson grade still relevant?* Clin Neurol Neurosurg. 2016 Jan 8;141:117-121 Authors: Gallagher MJ, Jenkinson MD, Brodbelt AR, Mills SJ, Chavredakis E Abstract OBJECTIVE: To examine whether Simpson grade and pathology location are still predictors of recurrence/progression free survival (RPFS) in WHO grade 1 cranial meningiomas. METHODS: A retrospective case series of all WHO grade 1 cranial meningiomas undergoing surgical resection at our institution between 2002 to 2007 was performed. Demographic and outcome data included: Si... περισσότερα »
(125)I interstitial brachytherapy for the treatment of myoepithelial carcinoma of the oral and maxillofacial region.
*(125)I interstitial brachytherapy for the treatment of myoepithelial carcinoma of the oral and maxillofacial region.* Brachytherapy. 2016 Jan 5; Authors: Zheng L, Lv X, Shi Y, Zhang Y, Yu G, Zhang J Abstract PURPOSE: This study evaluated the treatment of myoepithelial carcinoma (MC) of the oral and maxillofacial region with radioactive iodine ((125)I) seed implantation. METHODS AND MATERIALS: Twenty-seven patients with MC in the oral and maxillofacial region were treated with (125)I seed implantation between March 2006 and October 2012. Thirteen of the 27 patients (8/8 patients ...περισσότερα »
Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents.
*Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-tumor Immunity to Promising Targets for Developing Therapeutic Agents.* Front Oncol. 2015;5:300 Authors: Daniotti JL, Lardone RD, Vilcaes AA Abstract Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of vertebrate plasma membranes. Changes in the expression of certain species of gangliosides have b... περισσότερα »
Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives.
*Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives.* Front Oncol. 2015;5:299 Authors: Marugán C, Torres R, Lallena MJ Abstract Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B. Current drugs, which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules), have several side effects (neutropenia, alopecia, and emesis). Pharmaceutical companies aim at avoiding these unwanted effects by generating improved...περισσότερα »
Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.
*Human Papilloma Virus Identification in Breast Cancer Patients with Previous Cervical Neoplasia.* Front Oncol. 2015;5:298 Authors: Lawson JS, Glenn WK, Salyakina D, Clay R, Delprado W, Cheerala B, Tran DD, Ngan CC, Miyauchi S, Karim M, Antonsson A, Whitaker NJ Abstract PURPOSE: Women with human papilloma virus (HPV)-associated cervical neoplasia have a higher risk of developing breast cancer than the general female population. The purpose of this study was to (i) identify high-risk HPVs in cervical neoplasia and subsequent HPV positive breast cancers which developed in the same...περισσότερα »
Aurora-A Kinase as a Promising Therapeutic Target in Cancer.
*Aurora-A Kinase as a Promising Therapeutic Target in Cancer.* Front Oncol. 2015;5:295 Authors: D'Assoro AB, Haddad T, Galanis E Abstract Mammalian Aurora family of serine/threonine kinases are master regulators of mitotic progression and are frequently overexpressed in human cancers. Among the three members of the Aurora kinase family (Aurora-A, -B, and -C), Aurora-A and Aurora-B are expressed at detectable levels in somatic cells undergoing mitotic cell division. Aberrant Aurora-A kinase activity has been implicated in oncogenic transformation through the development of chromo... περισσότερα »
Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons.
*Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons.* Front Oncol. 2015;5:294 Authors: Simoniello P, Wiedemann J, Zink J, Thoennes E, Stange M, Layer PG, Kovacs M, Podda M, Durante M, Fournier C Abstract The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of hu... περισσότερα »
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.
*Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.* Front Oncol. 2015;5:287 Authors: Khallouki F, de Medina P, Caze-Subra S, Bystricky K, Balaguer P, Poirot M, Silvente-Poirot S Abstract Tocols are vitamin E compounds that include tocopherols (TPs) and tocotrienols (TTs). These lipophilic compounds are phenolic antioxidants and are reportedly able to modulate estrogen receptor β (ERβ). We investigated the molecular determinants that control their estrogenicity and effects on the proliferation of breast cancer cells. Docking... περισσότερα »
Outcomes and Predictors of Toxicity after Selective Internal Radiation Therapy Using Yttrium-90 Resin Microspheres for Unresectable Hepatocellular Carcinoma.
*Outcomes and Predictors of Toxicity after Selective Internal Radiation Therapy Using Yttrium-90 Resin Microspheres for Unresectable Hepatocellular Carcinoma.* Front Oncol. 2015;5:292 Authors: Gabrielson A, Miller A, Banovac F, Kim A, He AR, Unger K Abstract PURPOSE: We sought to report outcomes and toxicity in patients with hepatocellular carcinoma (HCC) who received resin yttrium-90 selective internal radiation therapy ((90)Y-SIRT) and to identify factors associated with declining liver function. METHODS: Patients treated with (90)Y-SIRT were retrospectively evaluated. Radiogr... περισσότερα »
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.
*Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly.* Front Oncol. 2015;5:283 Authors: Asteriti IA, De Mattia F, Guarguaglini G Abstract The Aurora kinase A (AURKA) is involved in different aspects of mitotic control, from mitotic entry to cytokinesis. Consistent with its pleiotropic roles, several AURKA interactors are able to modulate its activity, the best characterized being the microtubule-binding protein TPX2, the centrosomal protein Cep192, and Bora. Bora has been described as an essential cofactor of AURKA for phosphorylation-mediated activation of th... περισσότερα »
Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma.
*Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma.* Front Oncol. 2015;5:279 Authors: Redini F, Heymann D Abstract Ewing sarcoma is the second most common pediatric bone tumor, with three cases per million worldwide. In clinical terms, Ewing sarcoma is an aggressive, rapidly fatal malignancy that mainly develops not only in osseous sites (85%) but also in extra-skeletal soft tissue. It spreads naturally to the lungs, bones, and bone marrow with poor prognosis in the two latter cases. Bone lesions from primary or secondary (metastases) tumors are character...περισσότερα »
Predictors of acute diverticulitis severity: a systematic review.
*Predictors of acute diverticulitis severity: a systematic review.* Int J Surg. 2016 Jan 8; Authors: Tan JP, Barazanchi AW, Singh PP, Hill AG, Maccormick AD Abstract BACKGROUND: Diverticulitis is a common condition with a broad spectrum of disease severity. A scoring system has been proposed for diagnosing diverticulitis, and a number of scoring systems exist for predicting prognosis associated with severe complications of diverticulitis such as peritonitis. However, predicting disease severity has not received as much attention. Therefore, the aim of this review was to identify ... περισσότερα »
Pancreatic tumors: Imaging update 2015.
*Pancreatic tumors: Imaging update 2015.* Int J Surg. 2016 Jan 8; Authors: Scialpi M, Reginelli A, Gravante S, Falcone G, Baccari P, Manganaro L, Palumbo B, Cappabianca S Abstract Today, ultrasound (US), computed tomography (CT) and Magnetic Resonance imaging (MRI) repesent the mainstay in the evaluation of pancreatic solid and cystic tumors affecting pancreas in 80-85% and 10-15% of the cases respectively. Integration of US, CT or MR imaging is essential for an accurate assessment of pancreatic parenchyma, ducts and adjacent soft tissues in order to detect and to stage the tumo...περισσότερα »
Surgical techniques to avoid lateral dog ear of the mastectomy scar: A systematic review.
*Surgical techniques to avoid lateral dog ear of the mastectomy scar: A systematic review.* Int J Surg. 2016 Jan 14; Authors: Lim GH, Tan HF Abstract INTRODUCTION: Mastectomy is commonly performed for breast cancer. However, a dog ear may arise at the lateral aspect of the mastectomy scar. This dog ear is not only unsightly but can also be a source of discomfort. While various surgical techniques have been reported to tackle this lateral dog ear, there is no standardized technique. We hence conduct the first systematic review of these surgical techniques with the aim of comparin...περισσότερα »
Pneumocephalus leading to the diagnosis of cerebrospinal fluid leak and esophageal perforation after cervical spine surgery.
*Pneumocephalus leading to the diagnosis of cerebrospinal fluid leak and esophageal perforation after cervical spine surgery.* J Clin Neurosci. 2015 Nov 19; Authors: Goodwin CR, Boone CE, Pendleton J, Elder BD, Wei Z, Hsu W, Sciubba DM, Witham TF Abstract Pneumocephalus is a collection of air within in the intracranial cavity, most commonly seen following traumatic injury or cranial surgeries. Esophageal injury and cerebrospinal fluid (CSF) leak are rare complications that may occur following anterior cervical discectomy and fusion (ACDF). We present a novel case of pneumocephal...περισσότερα »
EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum
EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum: AbstractMitochondrial aminoacyl tRNA synthetases are essential for organelle protein synthesis. Genetic defects affecting the function of these enzymes may cause pediatric mitochondrial disease. Here, we report on a child with fatal neonatal lactic acidosis and recurrent hypoglycemia caused by mutations in *EARS2*, encoding mitochondrial glutamyl-tRNA synthetase 2. Brain ultrasound revealed agenesis of corpus callosum. Studies on patient-derived skin fibroblasts showed seve... περισσότερα »
Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma
Correlation of Cyfra 21-1 levels in saliva and serum with CK19 mRNA expression in oral squamous cell carcinoma: AbstractOral squamous cell carcinoma (OSCC) accounts for 90 % of malignant lesions of oral cavity. The study assessed the potential of Cyfra 21-1 as a tumor marker in OSCC. The study included 50 patients of OSCC to evaluate levels of Cyfra 21-1 in serum and saliva by electrochemiluminescent immunoassay (ECLIA) and CK19 messenger RNA (mRNA) expression in tissue by florescent quantitative real-time reverse transcriptase polymerase chain reaction (RT-PCR) along with healthy ... περισσότερα »
Pharmacokinetic interaction between pazopanib and cisplatin regimen
Pharmacokinetic interaction between pazopanib and cisplatin regimen: Abstract PurposeA phase I study combining daily oral pazopanib and cisplatin (given iv every 3 weeks) was performed in order to determine the maximum tolerated dose of both drugs in combination. Pharmacokinetic interactions were evaluated. MethodsPlasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients treated according to four levels of dose corresponding to 200, 400 or 600 mg daily dose of pazopanib and 60 or 75 mg/m2 of cisplatin. Two sequences of treatment were performed i...περισσότερα »
Chemotherapy induced thrombocytopenia in pediatric oncology
Chemotherapy induced thrombocytopenia in pediatric oncology via Critical Reviews in Oncology/Hematology (open access) Publication date: Available online 15 January 2016 *Source:*Critical Reviews in Oncology/Hematology Author(s): Gevorg Tamamyan, Samvel Danelyan, Michele P. Lambert Thrombocytopenia has long been recognized as a significant problem of cancer therapy, but there is still lack of consensus about the optimal approach to prophylaxis and/or treatment of this important complication. In pediatric oncology, since there are very few studies dedicated to this problem, the knowledge ...περισσότερα »
Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients
Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients: AbstractThe aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red blood cell parameters (hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW)), platelet ...περισσότερα »
Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status
Effect of Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status in Obese Patients with Treated Hypertension: AbstractThe effects of *Spirulina maxima* supplementation on calcium, magnesium, iron, and zinc status were studied in a double-blind placebo-controlled trial of 50 obese subjects with treated hypertension, each randomized to receive 2 g of spirulina or a placebo daily for 3 months. At baseline and after treatment, the calcium, magnesium, iron, and zinc concentration in plasma was assessed. It was found that 3 months of *S*. *maxima* supplementation r... περισσότερα »
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment
177 Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment: Abstract BackgroundMetastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly, patients with multiple metastatic lesions benefit from bone-targeting therapeutic radiopharmaceut... περισσότερα »
Targeted scVEGF/ 177 Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy
Targeted scVEGF/ 177 Lu radiopharmaceutical inhibits growth of metastases and can be effectively combined with chemotherapy: Abstract BackgroundscVEGF/177Lu is a novel radiopharmaceutical targeted by recombinant single-chain (sc) derivative of vascular endothelial growth factor (VEGF) that binds to and is internalized by vascular endothelial growth factor receptors (VEGFR). scVEGF/177Lu potential as adjuvant and neoadjuvant anti-angiogenic therapy was assessed in metastatic and orthotopic mouse models of triple-negative breast cancer. MethodsMetastatic lesions in Balb/c mice we...περισσότερα »
How doctors communicate the initial diagnosis of cancer matters
How doctors communicate the initial diagnosis of cancer matters: cancer disclosure and its relationship with Patients' hope and trust: Abstract Objective The study is to examine the relationships between perceived initial cancer disclosure communication with doctors, levels of hope, and levels of trust in doctors among cancer patients in China. Methods A total number of 192 cancer inpatients in a cancer hospital in China were surveyed. Perceived disclosure strategies, levels of hope, levels of trust in their doctors, as well as the demographic information were obtained from the part... περισσότερα »
Prescribing practices of antidepressants in cancer patients
A systematic review and meta-analysis of prescribing practices of antidepressants in cancer patients: Abstract Background Antidepressants are commonly used for the pharmacological treatment of depression. We aimed to summarise the prevalence of antidepressant prescription to cancer patients, and differences by study or patient characteristics. Methods PubMed, Embase, Web of Science, Scopus and psychINFO were searched using keywords ‘psychotropic’, ‘antidepressants’, ‘prescription’ and ‘cancer’. Prevalence of antidepressants, type, dose and follow-up of antidepressants and prescribe... περισσότερα »
Thyroid cytopathologic diagnosis of atypia (or follicular lesion) of undetermined significance (AUS/FLUS)
Triage of patients with AUS/FLUS on thyroid cytopathology: effectiveness of the multimodal diagnostic techniques: Abstract The management of patients with thyroid cytopathologic diagnosis of atypia (or follicular lesion) of undetermined significance (AUS/FLUS) is a complex clinical problem. The purpose of this study was to develop a practical triage scheme based on multiple diagnostic tests in general use. We performed a retrospective cohort study involving 15,335 consecutive patients with a referral diagnosis of thyroid nodule between April 2011 and March 2015 using an institution... περισσότερα »
Unplanned excision of sarcoma before referral to specialist centers
Characteristics of 64 sarcoma patients referred to a sarcoma center after unplanned excision: Background and Methods Unplanned excision of sarcoma before referral to specialist centers can affect prognosis and surgical outcome. The diagnostic pathway of these patients is uncertain and needs to be reviewed. We aimed to describe patient and tumor characteristics, initial symptoms, initial and final diagnosis, and explore reasons for unplanned excision in this patient group. From a previous study on 258 sarcoma patients, we identified 64 patients referred after surgery. Medical record...περισσότερα »
Completion thyroidectomy and total thyroidectomy for differentiated thyroid cancer: Comparison and prediction of postoperative hypoparathyroidism
Completion thyroidectomy and total thyroidectomy for differentiated thyroid cancer: Comparison and prediction of postoperative hypoparathyroidism: Background Consensus regarding the difference of postoperative hypoparathyroidism following completion thyroidectomy (CT) and total thyroidectomy (TT) has yet to be reached. We compare the occurrence of postoperative hypoparathyroidism between CT and TT for differentiated thyroid cancer (DTC), and explore the predictive factors for postoperative hypoparathyroidism. Methods We retrospectively reviewed 221 consecutive patients underwent CT ... περισσότερα »
Gastric cardia adenocarcinoma microRNA profiling
Gastric cardia adenocarcinoma microRNA profiling in Chinese patients: AbstractGastric cardia adenocarcinoma (GCA), which occurs at the gastroesophageal boundary, is one of the most malignant types of cancer. Over the past 30 years, the incidence of GCA has increased by approximately sevenfold, which has a more substantial increase than that of many other malignancies. However, as previous studies mainly focus on non-cardia gastric cancer, until now, the mechanisms behind GCA remain largely unknown. MicroRNAs (miRNAs) have been shown to play pivotal roles in carcinogenesis. To gain ...περισσότερα »
The Effects of Lithium Administration on Oxidant/Antioxidant Status
The Effects of Lithium Administration on Oxidant/Antioxidant Status in Rats: Biochemical and Histomorphological Evaluations: AbstractPresent study was planned to determine possible dose-dependent effects of lithium (Li) on oxidant-antioxidant status and histomorphological changes in liver and kidney tissues. For this purpose, twenty-four Wistar male rats were equally divided into three groups: the rats in group I served as controls, drinking tap water without lithium. Groups II and III received 0.1 and 0.2 % lithium carbonate (Li2CO3) through their drinking water, respectively, for... περισσότερα »
Sentinel lymph node identification in breast cancer and melanoma, a plea for tracer mapping
A systematic review and meta-analyses of via European Journal of Surgical Oncology (EJSO) Publication date: Available online 18 January 2016 *Source:*European Journal of Surgical Oncology (EJSO) Author(s): M.G. Niebling, R.G. Pleijhuis, E. Bastiaannet, A.H. Brouwers, G.M. van Dam, H.J. Hoekstra PurposeSentinel lymph node biopsy (SLNB) has become a widely accepted staging procedure for both breast carcinoma and melanoma. The aim of our study was to systematically review different SLNB techniques and perform a meta-analysis for corresponding identification and false-negative rates.Metho... περισσότερα »
Video-assisted thoracoscopic surgery (VATS) procedure is superior to limited thoracotomy (LT) for segmentectomy
Limited thoracotomy for segmentectomy: a comparison of postoperative pain with thoracoscopic lobectomy: Abstract PurposesTo assess whether a video-assisted thoracoscopic surgery (VATS) procedure is superior to limited thoracotomy (LT) for segmentectomy; postoperative pain was compared between VATS-lobectomy (VATS-L) and LT-segmentectomy (LT-S). Widely opened anterolateral thoracotomy segmentectomy (WT-S) was used as a control. MethodsThis study was a retrospective analysis of prospectively collected data for 220 consecutive patients with stage I NSCLC treated between 2012 and ... περισσότερα »
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk: Abstract Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes *GDF7* (rs3072), *TBX5* (rs27... περισσότερα »
Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer
Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer: Standard chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is an optional treatment for patients with stage II-III esophageal cancer. However, there are some demerits in this regimen bec...
EACVI/HFA Cardiac Oncology Toxicity Registry in breast cancer patients: rationale, study design, and methodology (EACVI/HFA COT Registry)–EURObservational Research Program of the European Society of Cardiology.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Related Articles EACVI/HFA Cardiac Oncology Toxicity Registry in breast cancer patients: rationale, study design, and methodology (EACVI/HFA COT Registry)–EURObservational Research Program of the European Society of Cardiology. Eur Heart J Cardiovasc Imaging. 2015 May;16(5):466-70 Authors: Lancellotti P, Anker SD, Donal E, Edvardsen T, Popescu BA, Farmakis D, Filippatos G, Habib G, Maggioni AP, Jerusalem G, […]
Experiential thinking in creationism–a textual analysis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Related Articles Experiential thinking in creationism–a textual analysis. PLoS One. 2015;10(3):e0118314 Authors: Nieminen P, Ryökäs E, Mustonen AM Abstract Creationism is a religiously motivated worldview in denial of biological evolution that has been very resistant to change. We performed a textual analysis by examining creationist and pro-evolutionary texts for aspects of «experiential thinking», a cognitive […]
The impact of joint range of motion limitations on health-related quality of life in patients with haemophilia A: a prospective study.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Related Articles The impact of joint range of motion limitations on health-related quality of life in patients with haemophilia A: a prospective study. Haemophilia. 2015 May;21(3):e176-84 Authors: Chen CM, Huang KC, Chen CC, Huang SU, Huang CE, Chen YY, Hsu SL Abstract In patients with haemophilia A, repeated occurrences of haemarthrosis and synovitis lead to […]
Post-test probability for neonatal hyperbilirubinemia based on umbilical cord blood bilirubin, direct antiglobulin test, and ABO compatibility results
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Abstract Many hospitals opt for early postnatal discharge of newborns with a potential risk of readmission for neonatal hyperbilirubinemia. Assays/algorithms with the possibility to improve prediction of significant neonatal hyperbilirubinemia are needed to optimize screening protocols and safe discharge of neonates. This study investigated the predictive value of umbilical cord blood (UCB) testing for significant […]
Analytical Investigation for In Situ Stress Measurement with Rheological Stress Recovery Method and Its Application
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
In situ stress is one of the most important parameters in underground engineering. Due to the difficulty and weakness of current stress measurement methods in deep soft rock, a new one, rheological stress recovery (RSR) method, to determine three-dimensional stress tensor is developed. It is supposed that rock stresses will recover gradually with time and […]
High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
The role of Human Papillomavirus (HPV) in colorectal carcinogenesis remains elusive. Based on the high incidence of HPV-associated malignancies among Puerto Rican Hispanics, this study aimed to assess the prevalence of HPV infection and viral integration in colorectal tissues in order to evaluate its putative role in colorectal cancer (CRC). In this case-control study, the […]
Serum thyrotropin level of 30 μIU/mL is inadequate for preablative thyroglobulin to serve as a prognostic marker for differentiated thyroid cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Abstract Purpose Preablative-stimulated thyroglobulin (ps-Tg) has manifested its potential for predicting prognosis in patients with differentiated thyroid carcinoma (DTC), but its level can be affected by thyrotropin (TSH). The objective of this study was to evaluate the utility of ps-Tg in predicting individual response after radioactive iodine (RAI) therapy, and further explore the appropriate TSH […]
Erratum to: Intact IFN-γR1 Expression and Function Distinguishes Langerhans Cell Histiocytosis From Mendelian Susceptibility to Mycobacterial Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
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TNFA , ANXA11 and BTNL2 Polymorphisms in CVID Patients with Granulomatous Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
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An Algorithm for Real-Time Pulse Waveform Segmentation and Artifact Detection in Photoplethysmograms.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
An Algorithm for Real-Time Pulse Waveform Segmentation and Artifact Detection in Photoplethysmograms. IEEE J Biomed Health Inform. 2016 Jan 18; Authors: Fischer C, Domer B, Wibmer T, Penzel T Abstract Photoplethysmography has been used in a wide range of medical devices for measuring oxygen saturation, cardiac output, assessing autonomic function, and detecting peripheral vascular disease. […]
Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer
Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer: Abstract BackgroundMounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, *Porphyromonas gingivalis*, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined the presence of *P. gingivalis* in esophageal mucosa, and the relationship between *P. gingiva...περισσότερα »
Graft-versus-host disease-like erythroderma: a manifestation of thymoma-associated multiorgan autoimmunity
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
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American Board of Dermatology Examination Dates
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
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Programmed Death Ligand 1 Immunohistochemistry- A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
*Programmed Death Ligand 1 Immunohistochemistry- A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society.* Arch Pathol Lab Med. 2016 Jan 18; Authors: Sholl LM, Aisner DL, Allen TC, Beasley MB, Borczuk AC, Cagle PT, Capelozzi V, Dacic S, Hariri L, Kerr KM, Lantuejoul S, Mino-Kenudson M, Raparia K, Rekhtman N, Roy-Chowdhuri S, Thunnissen E, Tsao MS, Yatabe Y Abstract The binding of programmed death ligands 1 and 2 (PD-L1 and PD-L2) to PD-1 blocks T-cell-mediated immune response to tumor. Antibodies that target programmed death 1 (PD-1) will ... περισσότερα »
A novel case presenting with an unusual ureteral diverticular lesion similar to adenomyomatous hyperplasia of the gallbladder
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
We present the first case of an unusual ureteral diverticular lesion demonstrating similarities to adenomyomatous hyperplasia of the gallbladder. A 68-year-old asymptomatic Japanese man with high prostate-specific antigen levels was clinically evaluated. Left hydronephrosis and benign prostatic hyperplasia were detected. A bilateral retrograde pyelogram revealed that the upper and middle portions of the left ureter exhibited an irregular narrow lumen and some pooling of contrast material, which was compatible with ureteral pseudodiverticulosis. Although no malignant cells were se...περισσότερα »
Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP-activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β-cell function in islets from rats subjected to CR for 21 days. Eight-week-old male rats were distributed into a control (CTL) group that was fed an isocaloric diet *ad libitum* or a CR group that received 60% of the food consumed by the CTL group. From days 18–21, CTL and CR rats were treated with sense (CTLS and CRS) or antisense (CTLAS and CRAS) AMPKα2 oligonucleotides. Caloric restri... περισσότερα »
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Summary There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein–Barr virus (EBV). In this study we found that restoration of miR-1 dramatically inhibited cell invasion *in vitro*, together with tumour growth and metastasis *in vivo*. Importantly, we found that LMP1, an Epstein–Barr virus (EBV)-associated protein, suppressed miR-1 expression. Furthermo... περισσότερα »
Characterization of lesion formation in marmosets following inhalational challenge with different strains of Burkholderia pseudomallei
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Summary The marmoset model of melioidosis was used to explore whether there was any difference in the disease presentation and/or the lesion formation following inhalational challenge with one of four strains of *Burkholderia pseudomallei* (K96243, 1026b, HBPUB10303a and HBPUB10134a). Marmosets were challenged with a range of bacterial doses and bacterial load, histological and physiological features were determined temporally following lethal disease. Melioidosis presented as an acute, febrile disease with bacteraemia, bacterial dissemination, necrotizing hepatitis, splenitis and ... περισσότερα »
Eyelid fat grafting: indications, operative technique and complications; a systematic review
Publication date: Available online 18 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Elodie Boureaux, Benoit Chaput, Sahar Bannani, Christian Herlin, Antoine De Runz, Raphael Carloni, Bruno Mortemousque, Frederic Mouriaux, Eric Watier, Nicolas Bertheuil IntroductionMany recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a com...περισσότερα »
Discopexy using resorbable pins in temporomandibular joint arthroscopy: Clinical and magnetic resonance imaging medium-term results
Publication date: Available online 18 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Rafael Martín-Granizo, Alejandrina Millón-Cruz PurposeTo describe the use of resorbable pins for disc fixation in a serie of patients and their medium-term outcomes.Materials and MethodsA study was conducted in 26 patients who underwent operative arthroscopic surgery and discopexy using resorbable pins. All patients were refractory to conservative treatment and presented, in at least one joint, anterior disc displacement without reduction on magnetic resonance imaging (MRI)....περισσότερα »
Three-dimensional analysis of maxillary stability after Le Fort I osteotomy using hydroxyapatite/poly-L-lactide plate
Publication date: Available online 19 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Jung Hyun Park, Minkyu Kim, Sang Yoon Kim, Hwi-Dong Jung, Young-Soo Jung PurposeTo evaluate three-dimensional change in maxillary position using biodegradable plates.Material and MethodsA total of 53 patients who underwent orthognathic surgery using biodegradable plates were analyzed retrospectively. The position of maxilla was measured three-dimensionally using cone beam computed tomography data at preoperative (T0), 1-month postoperative (T1), and 1-year postoperative (T2... περισσότερα »
Unknown primary tumors: is there a future therapeutic role for immune checkpoint inhibitors?
Unknown primary tumors: is there a future therapeutic role for immune checkpoint inhibitors?: Future Oncology Ahead of Print. [image: Free first page]
Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and its Expression Associates with Favorable Survival for Stage III Melanoma
Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and its Expression Associates with Favorable Survival for Stage III Melanoma: Purpose Inflammatory marker expression in stage III melanoma tumors was evaluated for association with outcome, using two independent cohorts of stage III melanoma patients' tumor tissues. Experimental Design Fifteen markers of interest were selected for analysis, and their expression in melanoma tissues was determined by immunohistochemistry. Proteins associating with either overall survival (OS) or relapse-free survival (RF...περισσότερα »
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk
The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk: Abstract Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes *GDF7* (rs3072), *TBX5* (rs27... περισσότερα »
Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer
Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer: Standard chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is an optional treatment for patients with stage II-III esophageal cancer. However, there are some demerits in this regimen bec...
A comprehensive review of the natural lymphaticovenous communications and their role in lymphedema surgery
A comprehensive review of the natural lymphaticovenous communications and their role in lymphedema surgery: Cancer-related lymphedema is a progressive, chronic condition that impairs quality of life. Its pathophysiology and the mechanisms of action of current reconstructive surgical treatments are not fully understood but lymphaticovenous communications may play a key role. We review the available literature on lymphaticovenous communications and their implications in lymphedema surgery, and propose a subclassification of lymphaticovenous communications. *J. Surg. Oncol*. © 2016 Wi...περισσότερα »
Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer
Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer: Abstract BackgroundMounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, *Porphyromonas gingivalis*, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined the presence of *P. gingivalis* in esophageal mucosa, and the relationship between *P. gingiva...περισσότερα »
Adolescents’ Attitudes to Sun Exposure and Sun Protection
Adolescents’ Attitudes to Sun Exposure and Sun Protection: AbstractAdolescents are considered a risk group for the development of skin cancer in later life due to their high rates of sunburn. The aim of this study is to evaluate the association between attitudes to sun exposure and the sociodemographic characteristics of adolescents, their habits, practices and knowledge. As a secondary goal, we describe the magnitude and sign of the correlations between these attitudes. Cross-sectional study of adolescent students from 12 secondary schools in southern Spain, the subjects were aske...περισσότερα »
Language of Uncertainty: the Expression of Decisional Conflict Related to Skin Cancer Prevention Recommendations
Language of Uncertainty: the Expression of Decisional Conflict Related to Skin Cancer Prevention Recommendations: AbstractUser-generated information on the Internet provides opportunities for the monitoring of health information consumer attitudes. For example, information about cancer prevention may cause decisional conflict. Yet posts and conversations shared by health information consumers online are often not readily actionable for interpretation and decision-making due to their unstandardized format. This study extends prior research on the use of natural language as a predict... περισσότερα »
Cytochrome P450 and Matrix Metalloproteinase Genetic Modifiers of Disease Severity in Cerebral Cavernous Malformation type 1
Cytochrome P450 and Matrix Metalloproteinase Genetic Modifiers of Disease Severity in Cerebral Cavernous Malformation type 1 via ScienceDirect Publication: Free Radical Biology and Medicine Publication date: Available online 19 January 2016 *Source:*Free Radical Biology and Medicine Author(s): Hélène Choquet, Eliana Trapani, Luca Goitre, Lorenza Trabalzini, Amy Akers, Marco Fontanella, Blaine L. Hart, Leslie A. Morrison, Ludmila Pawlikowska, Helen Kim, Saverio Francesco Retta BackgroundFamilial Cerebral Cavernous Malformation type 1 (CCM1) is an autosomal dominant disease caused by muta... περισσότερα »
Comparison of propofol and thiopentone along with ketamine for paediatric MRI sedation
Comparison of propofol and thiopentone along with ketamine for paediatric MRI sedation: 2016-01-19T04-18-40Z *Source:* International Journal of Research in Medical Sciences Kedareshvara K. S., M. G. Dhorigol, Rajesh Mane, Vandana Gogate. Background: Children are very much scared to undergo magnetic resonance imaging (MRI) brain or any body part even along with their parents for about 15 to 25 minutes. We investigated the combination of Propofol Ketamine and Thiopentone Ketamine along with Glycopyrolate and Midazolam premedication to see safe and better sedation group for paediatric...περισσότερα »
Perceptual-auditory and Acoustic Analysis of Air Traffic Controllers' Voices Pre- and Postshift.
Perceptual-auditory and Acoustic Analysis of Air Traffic Controllers' Voices Pre- and Postshift.: *Perceptual-auditory and Acoustic Analysis of Air Traffic Controllers' Voices Pre- and Postshift.* J Voice. 2016 Jan 5; Authors: Villar AC, Korn GP, Azevedo RR Abstract OBJECTIVE: To characterize the vocal quality and acoustic parameters of voices of air traffic controllers (ATCs) without any vocal complaints before and after a shift. METHOD: The voices of a group of 45 ATCs were recorded before and after a 2-hour shift, regardless of their operational position or number of previou... περισσότερα »
Noninferior response in BRAF(V600E) mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy.
Noninferior response in BRAF(V600E) mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy.: *Noninferior response in BRAF(V600E) mutant nonmetastatic papillary thyroid carcinoma to radioiodine therapy.* Eur J Nucl Med Mol Imaging. 2016 Jan 16; Authors: Li J, Liang J, Zhao T, Lin Y Abstract PURPOSE: As the most frequent and specific genetic alteration in papillary thyroid carcinoma (PTC), BRAF(V600E) has an intimate relationship with more invasive tumour and higher postoperative recurrence risk in PTC patients. We investigate the effect of radioactive iodine (RAI... περισσότερα »
Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: potential implications of inflammation bowel disease.
*Placental growth factor enhances angiogenesis in human intestinal microvascular endothelial cells via PI3K/Akt pathway: potential implications of inflammation bowel disease.* Biochem Biophys Res Commun. 2016 Jan 14; Authors: Zhou Y, Tu C, Zhao Y, Liu H, Zhang S Abstract BACKGROUND: Angiogenesis plays a major role in the pathogenesis of inflammatory bowel disease (IBD). Placental growth factor (PlGF) is a specific regulator of pathological angiogenesis and is upregulated in the sera of IBD patients. Therefore, the role of PlGF in IBD angiogenesis was investigated here using HIME... περισσότερα »
Ten years of anti-vascular endothelial growth factor therapy.
*Ten years of anti-vascular endothelial growth factor therapy.* Nat Rev Drug Discov. 2016 Jan 18; Authors: Ferrara N, Adamis AP Abstract The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both normal and pathological angiogenesis, has revealed innovative therapeutic approaches in oncology and ophthalmology. The first VEGFA inhibitor, bevacizumab, was approved by the US Food and Drug Administration in 2004 for the first-line treatment of metastatic colorectal cancer, and the first VEGFA inhibitors in ophthalmology, pegaptanib and ranibizumab, we...περισσότερα »
IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.
*IL-1β-regulating angiogenic factors expression in perforated temporomandibular disk cells via NF-κB pathway.* J Oral Pathol Med. 2016 Jan 17; Authors: Xu J, Cai H, Meng Q, Li Y, Chen G, Fang W, Long X Abstract BACKGROUND: A high density of blood vessels is observed in the perforated disks of temporomandibular joint (TMJ), but the underlying mechanism is unknown. This study aimed to explore the regulation of disk angiogenesis in the perforated disks. METHODS: Expressions of vascular endothelial growth factor (VEGF), angiogenin-1 (Ang-1), chondromodulin-1 (ChM-1), and thrombospond... περισσότερα »
Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone.* Int J Mol Sci. 2015;16(5):10888-906 Authors: Lin X, Peng Z, Su C Abstract Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been reported for their wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, antiulcer, and anthelmintic activities... περισσότερα »
Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Epidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinoma.* PLoS One. 2015;10(2):e0119723 Authors: Wang WM, Zhao ZL, Ma SR, Yu GT, Liu B, Zhang L, Zhang WF, Kulkarni AB, Sun ZJ, Zhao YF Abstract Angiogenesis, a marker of cancer development, affects response to radiotherapy sensibility. This preclinical study aims to understand the receptor tyrosine kinase-mediated angiogenesis in head neck squamous ce...περισσότερα »
Anti-angiogenic effect of Nelumbo nucifera leaf extracts in human umbilical vein endothelial cells with antioxidant potential.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Anti-angiogenic effect of Nelumbo nucifera leaf extracts in human umbilical vein endothelial cells with antioxidant potential.* PLoS One. 2015;10(2):e0118552 Authors: Lee JS, Shukla S, Kim JA, Kim M Abstract Nelumbo nucifera Gaertn (Nymphaeaceae) has long been used as a traditional herb in Chinese, Japanese, Indian, and Korean medicinal practices since prehistoric times and flourishes today as the primary form of medicine. This study reports for the first time the potent ability of N. nu... περισσότερα »
Erratum.
*Erratum.* J Clin Endocrinol Metab. 2016 Jan 18;:jc20161108 Authors: PMID: 26780571 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1Ou1I5C via IFTTT
Corrigendum.
*Corrigendum.* J Clin Endocrinol Metab. 2016 Jan 18;:jc20154260 Authors: PMID: 26780570 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1Ou1I5A via IFTTT
Simulants of Malignant Melanoma.
*Simulants of Malignant Melanoma.* Oncol Rev. 2015 Feb 10;9(1):278 Authors: Piérard GE, Piérard-Franchimont C, Delvenne P Abstract During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fi...περισσότερα »
A Network-Based Model of Oncogenic Collaboration for Prediction of Drug Sensitivity.
*A Network-Based Model of Oncogenic Collaboration for Prediction of Drug Sensitivity.* Front Genet. 2015;6:341 Authors: Laderas TG, Heiser LM, Sönmez K Abstract Tumorigenesis is a multi-step process, involving the acquisition of multiple oncogenic mutations that transform cells, resulting in systemic dysregulation that enables proliferation, invasion, and other cancer hallmarks. The goal of precision medicine is to identify therapeutically-actionable mutations from large-scale omic datasets. However, the multiplicity of oncogenes required for transformation, known as oncogenic ... περισσότερα »
Primary leptomeningeal glioblastoma with systemic metastases-case report and review of literature.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary leptomeningeal glioblastoma with systemic metastases-case report and review of literature.* Clin Imaging. 2015 Jul-Aug;39(4):672-6 Authors: Bathla G, Gupta S, Moritani T Abstract We present a case of a rare meningeal glioblastoma with extensive systemic metastases, along with a review of the existing literature. The patient presented with headache and visual and sensory symptoms and had a rapidly progressive clinical course despite therapy. The patient went on to develop spinal, orbital, muscular, and cut... περισσότερα »
Surgical treatment of potentially primary malignant adrenal tumors: an unresolved issue.
[image: http:--hormones.gr-images-fulltext.gif] Related Articles *Surgical treatment of potentially primary malignant adrenal tumors: an unresolved issue.* Hormones (Athens). 2015 Jan-Mar;14(1):47-58 Authors: Zografos GN, Perysinakis I, Kyrodimou E, Kassi E, Kaltsas G Abstract Although the great majority of incidentalomas are adrenocortical adenomas, a number of them, depending on the size and radiological characteristics of the lesions, will turn out to be carcinomas. These tumors may present as suspicious on initial evaluation and potentially malignant or malignant on histology... περισσότερα »
Fibromatosis of the breast mimicking an abscess: case report of unusual sonographic features.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Fibromatosis of the breast mimicking an abscess: case report of unusual sonographic features.* Clin Imaging. 2015 Jul-Aug;39(4):685-8 Authors: Lee SM, Lee JY, Lee BH, Kim SY, Joo M, Kim JI Abstract Fibromatosis of the breast, also known as a desmoid tumor, is extremely rare and most often appears as an aggressive lesion mimicking breast carcinoma. It lacks metastatic potential but can grow aggressively in a localized area. Ultrasonography often shows an irregular spiculated hypoechoic mass with posterior acoustic... περισσότερα »
Therapeutic strategy and outcome of spine tumors in pregnancy: a report of 21 cases and literature review.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Therapeutic strategy and outcome of spine tumors in pregnancy: a report of 21 cases and literature review.* Spine (Phila Pa 1976). 2015 Feb 1;40(3):E146-53 Authors: Meng T, Yin H, Li Z, Li B, Zhou W, Wang J, Zhou L, Song D, Xiao J Abstract STUDY DESIGN: A retrospective study was performed. OBJECTIVE: To illustrate the characteristics of spine tumors during pregnancy and obtain better insight into therapeutic strategies of such tumors by analyzing 21 cases treated in Changzheng Hospital and reviewing previous repor...περισσότερα »
Papillary thyroid cancer in a struma ovarii: a report of a rare case.
[image: http:--hormones.gr-images-fulltext.gif] Related Articles *Papillary thyroid cancer in a struma ovarii: a report of a rare case.* Hormones (Athens). 2015 Jan-Mar;14(1):154-9 Authors: Monti E, Mortara L, Zupo S, Dono M, Minuto F, Truini M, Naseri M, Giusti M Abstract After removal of an ovarian mass in a 43-year-old woman, a struma ovarii was diagnosed. Within this teratoma, a papillary thyroid cancer was found. The tumor was negative for BRAF, NRAS, KRAS, PIK3CA and c-KIT mutations on molecular analysis. Thyroid function and morphology were normal. Thyroidectomy, L-T4 TSH-...περισσότερα »
[Extremely rapid progression of oral cavity carcinosarcoma].
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *[Extremely rapid progression of oral cavity carcinosarcoma].* Rev Stomatol Chir Maxillofac Chir Orale. 2013 Dec;114(6):356-9 Authors: Lebourg G, de Muret A, Goga D Abstract INTRODUCTION: Carcinosarcoma is a very rare malignant tumor of the salivary glands including accessory salivary gland, associating malignant mesenchymal and epithelial tissue. It usually occurs after 50 years of age. Its prognosis is very poor. We present a case of carcinosarcoma having evolved extremely rapidly. CASE REPORT: A 38-year-old fema... περισσότερα »
[Extended resection and radiotherapy for primary intraosseous maxillary carcinoma].
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *[Extended resection and radiotherapy for primary intraosseous maxillary carcinoma].* Rev Stomatol Chir Maxillofac Chir Orale. 2013 Dec;114(6):349-55 Authors: Dujoncquoy JP, Rojare C, Chemli H, Wojcik T, Raoul G, Ferri J Abstract INTRODUCTION: Primary intraosseous maxillary carcinoma is a rare squamous cell carcinoma developing from remnants of the odontogenic epithelium. Risk factors are unknown and it may occur at any age. Little epidemiological data is available and few series include a sufficient number of pati...περισσότερα »
[Solitary fibrous tumor of the orbit: Possibly recurrent in the long-run].
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *[Solitary fibrous tumor of the orbit: Possibly recurrent in the long-run].* Rev Stomatol Chir Maxillofac Chir Orale. 2013 Dec;114(6):366-71 Authors: Rougeot A, Barnoud R, Ferri J, Béziat JL Abstract Solitary fibrous tumor (SFT) is a rare etiology of progressive unilateral exophthalmia. The tumor is of mesenchymal origin and it is usually well defined. But recurrences can occur despite of complete surgical resection. Metastases have been observed. Tumors of the SFT spectrum are considered as benign or low-grade mal... περισσότερα »
Preadmission bisphosphonate and mortality in critically ill patients.
*Preadmission bisphosphonate and mortality in critically ill patients.* J Clin Endocrinol Metab. 2016 Jan 18;:jc20153467 Authors: Lee P, Ng C, Slattery A, Nair P, Eisman JA, Center JR Abstract CONTEXT: Increased bone resorption predicts mortality and bone resorption heightens during critical illness. Bisphosphonates are potent inhibitors of bone resorption. Whether bisphosphonate impacts clinical outcome of Intensive Care Unit (ICU) admission is unknown. OBJECTIVE: We investigated the relationship between preadmission bisphosphonate use and clinical outcome in critically ill patie...περισσότερα »
Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation.
*Sinonasal Globular Amyloidosis Simulating Malignancy: A Rare Presentation.* Head Neck Pathol. 2016 Jan 16; Authors: Kumar B, Pant B, Kumar V, Negi M Abstract Primary localized amyloidosis in the head and neck region is a rare entity. The most commonly involved organ is larynx. Primary amyloidosis localized to the sinonasal tract is extremely rare. We report one such case along with a brief review of the associated literature. The aim of reporting this case is to emphasize the fact that sometimes nasal amyloidosis can also present with signs and symptoms of nasal and nasopharynge...περισσότερα »
Corrigendum.
*Corrigendum.* J Clin Endocrinol Metab. 2016 Jan 18;:jc20154260 Authors: PMID: 26780570 [PubMed - as supplied by publisher] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1Ou1I5A via IFTTT
Preadmission bisphosphonate and mortality in critically ill patients.
*Preadmission bisphosphonate and mortality in critically ill patients.* J Clin Endocrinol Metab. 2016 Jan 18;:jc20153467 Authors: Lee P, Ng C, Slattery A, Nair P, Eisman JA, Center JR Abstract CONTEXT: Increased bone resorption predicts mortality and bone resorption heightens during critical illness. Bisphosphonates are potent inhibitors of bone resorption. Whether bisphosphonate impacts clinical outcome of Intensive Care Unit (ICU) admission is unknown. OBJECTIVE: We investigated the relationship between preadmission bisphosphonate use and clinical outcome in critically ill patie...περισσότερα »
upper respiratory tract infection; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/01/19 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/QGMHBq(((upper%20respiratory%20tract%20infection)%20AND%20%222016%2F01%2F16%2006.22%22%5B...περισσότερα »
Vestibular results after intratympanic gentamicin therapy in disabling Menière's disease.
*Vestibular results after intratympanic gentamicin therapy in disabling Menière's disease.* Eur Arch Otorhinolaryngol. 2016 Jan 16; Authors: Junet P, Karkas A, Dumas G, Quesada JL, Schmerber S Abstract Intratympanic injection of gentamicin is increasingly used in the treatment of unilateral disabling Menière's disease (MD). Several objective functional and subjective tests have been developed to assess the control of vertigo after gentamicin treatment. The aim of this study was to show that subjective results require a vestibular deafferentation as profound as possible, evidence... περισσότερα »
A Potential Role for Aromatase Levels in Coronary Heart Disease.
*A Potential Role for Aromatase Levels in Coronary Heart Disease.* Genet Test Mol Biomarkers. 2016 Jan;20(1):1 Authors: Ehrlich GD PMID: 26780325 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1lqvEoW via IFTTT
Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma.
*Intraoperative optical assessment of photodynamic therapy response of superficial oral squamous cell carcinoma.* J Biomed Opt. 2016 Jan 1;21(1):18002 Authors: Rohrbach DJ, Rigual N, Arshad H, Tracy EC, Cooper MT, Shafirstein G, Wilding G, Merzianu M, Baumann H, Henderson BW, Sunar U PMID: 26780226 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1Ni7cwr via IFTTT
FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma.
*FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma.* Oral Oncol. 2016 Jan 8; Authors: Ozretić L, Wagner S, Huebbers CU, Gattenlöhner S, Klussmann JP, Beutner D, Zander T, Buettner R, Quaas A PMID: 26778475 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1nhOd0b via IFTTT
Temperature Sensitive Auditory Neuropathy.
*Temperature Sensitive Auditory Neuropathy.* Hear Res. 2016 Jan 14; Authors: Zhang Q, Lan L, Shi W, Yu L, Xie LY, Xiong F, Zhao C, Li N, Yin Z, Zong L, Guan J, Wang D, Sun W, Wang Q Abstract Temperature sensitive auditory neuropathy is a very rare and puzzling disorder. In the present study, we reported three unrelated 2 to 6 year-old children who were diagnosed as auditory neuropathy patients who complained of severe hearing loss when they had fever. Their hearing thresholds varied from the morning to the afternoon. Two of these patients' hearing improved with age, and one pati...περισσότερα »
Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures.
*Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures.* Toxicol Lett. 2016 Jan 14; Authors: Kim YR, Kim MA, Cho HJ, Oh SK, Lee IK, Kim UK, Lee KY Abstract Amikacin is a semi-synthetic aminoglycoside widely used to treat infections caused by gentamicin-resistant gram-negative organisms and nontuberculous mycobacteria. However, the use of this agent often results in ototoxicity due to the overproduction of reactive oxygen species (ROS). Galangin, a natural flavonoid, has been shown to play... περισσότερα »
A Detailed Motion Analysis of the Angular Velocity Between the Vocal Folds During Throat Clearing Using High-speed Digital Imaging.
*A Detailed Motion Analysis of the Angular Velocity Between the Vocal Folds During Throat Clearing Using High-speed Digital Imaging.* J Voice. 2016 Jan 5; Authors: Iwahashi T, Ogawa M, Hosokawa K, Kato C, Inohara H Abstract OBJECTIVES: To assess the angular velocity between the vocal folds just before the compression phase of throat clearing (TC) using high-speed digital imaging (HSDI) of the larynx. METHODS: Twenty normal healthy adults (13 males and seven females) were enrolled in the study. Each participant underwent transnasal laryngo-fiberscopy, and was asked to perform weak... περισσότερα »
Graft-versus-host disease-like erythroderma: a manifestation of thymoma-associated multiorgan autoimmunity
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American Board of Dermatology Examination Dates
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Biomarkers and Personalized Medicine: Current Status and Further Perspectives with Special Focus on Dermatology
Abstract Biomarkers are of high and further increasing importance in medicine, particularly in the realm of 'personalized medicine'. They are valuable for predicting prognosis and dose selection. Moreover they may be helpful in detecting therapeutic and adverse responses, and in patient stratification based on efficacy or safety prediction. Thus, biomarkers are essential tools for the selection of appropriate patients for treatment with certain drugs and enable personalized medicine, i.e. 'providing the right treatment to the right patient, at the right dose at the right time'. Cur... περισσότερα »
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Issue Information – Table of Contents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Magnetic resonance elastography of frontotemporal dementia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose To investigate the feasibility of utilizing brain stiffness as a potential biomarker for behavioral variant frontotemporal dementia (bvFTD) patients. Magnetic resonance elastography (MRE) is a noninvasive technique for evaluating the mechanical properties of brain tissue in vivo. MRE has demonstrated decreased brain stiffness in patients with Alzheimer’s disease. Materials and Methods We examined five […]
A retrospective comparative analysis of elderly and younger patients undergoing pulmonary resection for stage I non-small cell lung cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Age has been a critical predictor for immediate postoperative and long-term results after the pulmonary resection for lung cancer. In this study, we evaluated and compared surgical outcome of stage I non-small cell lung cancer and associated predictive factors between elderly and younger groups. Methods Short- and long-term outcomes of elderly group (≥70 […]
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Table of Contents
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Parents’ evaluation of the IDEFICS intervention: an analysis focussing on socio-economic factors, child’s weight status and intervention exposure
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
INTRODUCTION: From April 2008 to August 2010 the Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS (IDEFICS) intervention aimed to encourage healthier diets, higher physical activity levels and lower stress levels among European children and their families. While the intervention was intended to improve children’s health, we also wished to […]
Analysis of mutations in the core and NS5A genes of hepatitis C virus in non-responder and relapser patients after treatment with Peg-IFN-α and ribavirin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Mutations in several regions of HCV genome are shown to correlate with response to interferon (IFN) treatment. Persistence of HCV infection and poor susceptibility to treatment might be contributed by mutations arising within HCV genome which enable the virus to escape from host immune response/IFN treatment. This study investigated mutations in core and NS5A […]
Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP-activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β-cell function in islets from rats subjected to CR for 21 days. Eight-week-old male rats were distributed into a control (CTL) group that was fed an […]
K. Subramanya Sastry and Thomas A. Zitter: Plant virus and viroid diseases in the tropics, volume 2: epidemiology and management (Springer, 2014, 489 pp, ISBN 978-94-007-7819-1)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Complete genome sequencing and comparative analysis of three dengue virus type 2 Pakistani isolates
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Dengue is currently one of the most important arthropod borne human viral diseases caused by a flavivirus named as dengue virus. It is now endemic in Pakistan since many dengue fever outbreaks have been observed in Pakistan during the last three decades. Major serotype of dengue virus circulating in Pakistan is serotype 2. Complete […]
Iulius Casserius: revolutionary anatomist, teacher and pioneer of the sixteenth and seventeenth century
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The demand for anatomical illustrations in the early modern period coincided with a scientific revolution. Starting out as a servant, Iulius Casserius became a great anatomist, who challenged the Galenic doctrine. The aim of this paper is to honor his memory and recreate the stylism of his anatomical illustrations. Online databases were searched for […]
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
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Drowsiness detection using heart rate variability.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Drowsiness detection using heart rate variability. Med Biol Eng Comput. 2016 Jan 16; Authors: Vicente J, Laguna P, Bartra A, Bailón R Abstract It is estimated that 10-30 % of road fatalities are related to drowsy driving. Driver’s drowsiness detection based on biological and vehicle signals is being studied in preventive car safety. Autonomous nervous […]
Impact of different nasal masks on CPAP therapy for obstructive sleep apnea: A randomized comparative trial.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Impact of different nasal masks on CPAP therapy for obstructive sleep apnea: A randomized comparative trial. Clin Respir J. 2016 Jan 18; Authors: Neuzeret PC, Morin L Abstract INTRODUCTION: Patient interface is important for the success of continuous positive airway pressure (CPAP), but few trials have examined the influence of mask choice on CPAP adherence. […]
Changes in four plasma adipokines before and after sleep in OSAS patients.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Changes in four plasma adipokines before and after sleep in OSAS patients. Clin Respir J. 2016 Jan 18; Authors: Xu T, Lin Y, Sun S, Zhang Q Abstract OBJECTIVES: This study aimed to investigate whether plasma levels of four adipokines (chemerin, macrophage migratory inhibitory factor [MIF], visceral adipose tissue-derived serine protease inhibitor [vaspin], and chemokine […]
Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Male prairie voles display cardiovascular dipping associated with an ultradian activity cycle. Physiol Behav. 2016 Jan 15; Authors: Lewis R, Thomas Curtis J Abstract Mammals typically display alternating active and resting phases and, in most species, these rhythms follow a circadian pattern. The active and resting phases often are accompanied by corresponding physiological changes. In […]
Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Obstructive sleep apnoea and risks of all-cause mortality: preliminary evidence from prospective cohort studies. Sleep Breath. 2016 Jan 15; Authors: Pan L, Xie X, Liu D, Ren D, Guo Y Abstract PURPOSE: A meta-analysis of prospective cohort studies was conducted to clarify the association between obstructive sleep apnoea (OSA) and future risk of all-cause mortality. […]
The effectiveness of different mandibular advancement amounts in OSA patients: a systematic review and meta-regression analysis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The effectiveness of different mandibular advancement amounts in OSA patients: a systematic review and meta-regression analysis. Sleep Breath. 2016 Jan 15; Authors: Bartolucci ML, Bortolotti F, Raffaelli E, D’Antò V, Michelotti A, Alessandri Bonetti G Abstract PURPOSE: The therapy with mandibular advancement devices (MADs) represents a treatment option for patients with obstructive sleep apnea (OSA). […]
Tooth loss and obstructive sleep apnea signs and symptoms in the US population.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tooth loss and obstructive sleep apnea signs and symptoms in the US population. Sleep Breath. 2016 Jan 15; Authors: Sanders AE, Akinkugbe AA, Slade GD, Essick GK Abstract PURPOSE: The aim of this study is to investigate the relationship between tooth loss and signs and symptoms of obstructive sleep apnea (OSA) in a representative sample […]
Acknowledgements to reviewers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Antibiotics, Vol. 5, Pages 8: Antimicrobial Stewardship for a Geriatric Behavioral Health Population
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Antimicrobial resistance is a growing public health concern. Antimicrobial stewardship and multi-disciplinary intervention can prevent inappropriate antimicrobial use and improve patient care. Special populations, especially older adults and patients with mental health disorders, can be particularly in need of such intervention. The purpose of this project was to assess the impact of pharmacist intervention on […]
ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Neuroendocrinology from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1StuSG0 via IFTTT
Caliber persistent labial artery (CPLA): A rarely recognized cause of a lower lip swelling. Report of 5 cases and review of the literature
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): S Awni Mclin, B. Conn Caliber persistent labial artery (CPLA) is a vascular anomaly of the labial artery which penetrates into submucosa of the lip without reduction in diameter. It commonly presents as a bluish or normal color elevated soft tissue mass and usually pulsates on manual palpation.Five patients aged between 28 and 88 years old presenting with discrete lesions of the lower lip are presented. All cases were treated with excision biopsy. Persistence of the lesio... περισσότερα »
Immediate Versus Delayed Treatment of Mandibular Fractures: A Stratified Analysis of Complications
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Urie K. Lee, Ayleen Rojhani, Alan S. Herford, Jayini S. Thakker PurposeTo analyze the rate of complication outcomes of mandibular fracture repairs across different injury-to-repair time spans.Patients and MethodsThe investigators conducted a retrospective cohort study of patients with repaired mandible fractures. The independent variable was the time span from injury to surgical repair. The primary outcome variable was the rate of complications measured postoperatively dur... περισσότερα »
Custom-Machined Miniplates and Bone-Supported Guides for Orthognathic Surgery: A New Surgical Procedure
Publication date: Available online 18 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Joan Brunso Casellas., Maria Franco Echevarria., Thomas Constantinescu., Luis Barbier Herrero., Joseba Andoni Santamaría Zuazua., Julio Alvarez Amézaga. BackgroundSeveral surgical strategies exist to improve accuracy in orthognathic surgery (OGS), but ideal planning and treatment have yet to be described. The purpose of this study is to present and assess the accuracy of a virtual orthognathic positioning system (OPS), based on the use of bone-supported guides for placeme...περισσότερα »
Use of pentoxifylline and tocopherol in the management of osteoradionecrosis
Osteoradionecrosis (ORN) is a complication of radiotherapy, and is difficult to manage once established. However, its pathogenesis has been reinvestigated, and it is now thought to be potentially amenable to treatment with pentoxifylline and tocopherol (vitamin E). We made a retrospective analysis of 62 patients with established ORN who were treated in this way. When only pentoxifylline and vitamin E was used ORN resolved in 14/25 (56%) but paradoxically, when it was combined with antibiotics, only 6/22 resolved (27%). from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift... περισσότερα »
Accidental intraoral injection of formalin during extraction: case report
Transparent, clear solutions such as hydrogen peroxide, alcohol, sodium hypochlorite, formaldehyde, and local anaesthetics are widely used in dentistry, so the tissues are liable to accidental injury. Formalin, a 37%-40% solution of formaldehyde, is extensively used in 10% solution as a tissue preservative, but it has toxic effects on systems such as the gastrointestinal tract, respiratory tract, skin, and mucosa. However, we know of few reports of cases of inadvertent injection of alcohol and formalin directly into the human body. from #ΓναθοΧειρουργική via xlomafota13 on Inoread... περισσότερα »
Eyelid fat grafting: indications, operative technique and complications; a systematic review
Many recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a comprehensive literature review to determine the outcomes and complications of eyelid fat grafting, as well as patient satisfaction. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1lpaV4R via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,...περισσότερα »
Safety of the HyperSound® Audio System in Subjects with Normal Hearing.
*Safety of the HyperSound® Audio System in Subjects with Normal Hearing.* Audiol Res. 2015 Jun 11;5(2):136 Authors: Mehta RP, Mattson SL, Kappus BA, Seitzman RL Abstract The objective of the study was to assess the safety of the HyperSound® Audio System (HSS), a novel audio system using ultrasound technology, in normal hearing subjects under normal use conditions; we considered pre-exposure and post-exposure test design. We investigated primary and secondary outcome measures: i) temporary threshold shift (TTS), defined as >10 dB shift in pure tone air conduction thresholds and/or ... περισσότερα »
Chiropractic Response to a Spontaneous Vertebral Artery Dissection.
*Chiropractic Response to a Spontaneous Vertebral Artery Dissection.* J Chiropr Med. 2015 Sep;14(3):183-90 Authors: Tarola G, Phillips RB Abstract OBJECTIVE: The purpose of this case report is to describe a case in which early detection and proper follow-up of spontaneous vertebral artery dissection led to satisfactory outcomes. CLINICAL FEATURES: A 34-year old white woman reported to a chiropractic clinic with a constant burning pain at the right side of her neck and shoulder with a limited ability to turn her head from side to side, periods of blurred vision, and muffled hearing... περισσότερα »
Annals of Neurology: Volume 79, Number 1, January 2016
*ON THE COVER*: Tau PET study from a 70 year-old individual with a diagnosis of Mild Cognitive Impairment due to Alzheimer's disease, on the basis of a history of progressive memory impairment and elevated brain amyloid. Coronal PET image with the tau tracer 18F T807 (also known as AV1451; superimposed on MRI) shows high binding in red, localized in temporal neocortex, most prominently in inferior temporal gyrus bilaterally, with extension into middle and superior temporal gyri. The pattern of 18F T807 cortical binding is consistent with neurofibrillary tangle stage III/IV of Bra... περισσότερα »
Treatment with Mesna and n-3 polyunsaturated fatty acids ameliorates experimental ulcerative colitis in rats
Summary Oxidative damage is a central feature of ulcerative colitis. Here, we tested whether the antioxidant Mesna, when administered alone or in combination with n-3 polyunsaturated fatty acids (n-3 PUFAs), affects the outcome of dextran sodium sulphate (DSS)-induced ulcerative colitis in rats. After the induction of colitis, DSS-treated rats were further treated orally (p.o), intraperitoneally (i.p) or intrarectally (i.r) for either 7 or 14 days with Mesna, n-3 PUFAs or both. Rats were euthanized at the end of each treatment period. Clinical disease activity index was recorded t... περισσότερα »
Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-κB-dependent inflammatory/MMP-9 pathway
Summary Acute lung injury (ALI) is one of the most serious complications in traumatic patients and is an important part of multiple organ dysfunction syndrome (MODS). Recombinant human brain natriuretic peptide (rhBNP) is a peptide with a wide range of biological activity. In this study, we investigated local changes in oxidative stress and the NF-κB-dependent matrix metalloproteinase-9 (MMP-9) pathway in rats with trauma/haemorrhagic shock (TH/S)-induced ALI and evaluated the effects of pretreatment with rhBNP. Forty-eight rats were randomly divided into four groups: sham operati... περισσότερα »
Multiple pathways regulate Cten in colorectal cancer without a Tensin switch
Summary *CTEN/TNS4* is a member of the Tensin gene family. It localizes to focal adhesions and induces cell motility. The mechanisms regulating Cten expression are unclear although we have shown regulation by Kras in the colon and pancreas. In normal mammary cell lines, it is reportedly upregulated by epidermal growth factor receptor (EGFR) and STAT3 signalling and upregulation is accompanied by downregulation of Tensin 3 (Tensin switch). In this study, we investigated the roles of EGFR and STAT3 signalling in the regulation of Cten in colorectal cancer (CRC). In addition, we inve... περισσότερα »
Discopexy using resorbable pins in temporomandibular joint arthroscopy: Clinical and magnetic resonance imaging medium-term results
To describe the use of resorbable pins for disc fixation in a serie of patients and their medium-term outcomes. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1lpaSFX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
New miniplate for osteosynthesis of mandibular angle fractures designed to improve formation of new bone by reducing the perifocal strains near fracture line and loads in adjacent fixation screws
The purpose of this article is to present the study of a new miniplate designed to keep the maximum strains developed in the cortical surface near the fracture line during accidental biting to values below the threshold causing bone resorption. Designed to offer maximum fracture stability with minimal implanted volume and patient intrusion, the design uses a novel approach to account for the effects of the distance from the fracture line to the nearest screws. Its geometry minimizes the peak forces that can develop during most cases of mandible biomechanical loadings. from #ΓναθοΧ... περισσότερα »
Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis
Squamous cell cancers of the head and neck as a group represent the sixth most common malignancy worldwide [1]. While the overall incidence of head and neck cancers (HNC) at various anatomic subsites such as the ventrolateral tongue and floor of mouth has decreased in conjunction with reduced smoking and drinking rates, oropharyngeal squamous cell carcinomas (OPSCC) have increased mainly due to high-risk human papillomavirus (HPV) infection [2]. HPV is a sexually transmitted infection, and currently recognized as the most prevalent sexually transmitted infection in the United Stat...περισσότερα »
The Importance of Supportive Care with Tranexamic Acid in Crimean-Congo Hemorrhagic Fever
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This report describes a case of Crimean-Congo hemorrhagic fever with widespread hemorrhages and multiple organ dysfunction syndrome in a 46-year-old patient from an endemic region. Although the patient had numerous poor prognostic factors, he was discharged in a healthy condition after 17 days of hospitalization with close monitoring and supportive care. Tranexamic acid was successfully […]
Caliber persistent labial artery (CPLA): A rarely recognized cause of a lower lip swelling. Report of 5 cases and review of the literature
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): S Awni Mclin, B. Conn Caliber persistent labial artery (CPLA) is a vascular anomaly of the labial artery which penetrates into submucosa of the lip without reduction in diameter. It commonly presents as a bluish or normal color elevated soft tissue […]
Immediate Versus Delayed Treatment of Mandibular Fractures: A Stratified Analysis of Complications
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): Urie K. Lee, Ayleen Rojhani, Alan S. Herford, Jayini S. Thakker PurposeTo analyze the rate of complication outcomes of mandibular fracture repairs across different injury-to-repair time spans.Patients and MethodsThe investigators conducted a retrospective cohort study of patients with repaired mandible fractures. […]
Custom-Machined Miniplates and Bone-Supported Guides for Orthognathic Surgery: A New Surgical Procedure
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): Joan Brunso Casellas., Maria Franco Echevarria., Thomas Constantinescu., Luis Barbier Herrero., Joseba Andoni Santamaría Zuazua., Julio Alvarez Amézaga. BackgroundSeveral surgical strategies exist to improve accuracy in orthognathic surgery (OGS), but ideal planning and treatment have yet to be described. The purpose […]
Epistaxis management: current understanding amongst junior doctors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles R Fox, R Nash, Z-W Liu, A Singh The Journal of Laryngology Otology, FirstView Article(s), 4 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QkEZeQ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles J Y Soh, M Thalayasingam, S Ong, E X L Loo, L P Shek, S S Chao The Journal of Laryngology Otology, FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QkEYYe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Initial assessment of hearing loss using a mobile application for audiological evaluation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles S Derin, O H Cam, H Beydilli, E Acar, S S Elicora, M Sahan The Journal of Laryngology Otology, FirstView Article(s), 4 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QkEXDz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Garnett Passe and the tonsillectomy gag
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Review Articles J C Rice The Journal of Laryngology Otology, FirstView Article(s), 3 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QkEXn3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mammografie-Screening kann Krebs auslösen
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Einfluss der Brustgröße Die Screening-Mammografie kann nicht nur Todesfälle durch Brustkrebs verhindern, sondern selbst Mammakarzinome verursachen. Die Gefahr ist allgemein gering, aber für bestimmte Gruppen von Frauen nicht ganz trivial. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1lqe3gO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Adjuvant radiotherapy after radical prostatectomy: A failure of marketing-based medicine?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JeS87H via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Dissemination of CPR video self-instruction materials to secondary trainees: Results from a hospital-based CPR education trial
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1WqqoyS via IFTTT
Patient adherence to burn care: A systematic review of the literature
Burns from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZJxPqu via IFTTT
Acute ischemia and pink pulseless hand in 68 of 404 Gartland type III supracondylar humeral fractures in children: urgent management and therapeutic consensus
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1WqqlDn via IFTTT
Is a national time target for emergency department stay associated with changes in the quality of care for acute asthma? A multicentre pre-intervention post-intervention study
Emergency Medicine Australasia from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZJxPqn via IFTTT
Aortic hemostasis and resuscitation: preliminary experiments using selective aortic arch perfusion with oxygenated blood and intra-aortic calcium coadministration in a model of hemorrhage-induced traumatic cardiac arrest
Academic Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZJxO5S via IFTTT
Understanding the long-term impacts of burn on the cardiovascular system
Burns from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1WqqlmM via IFTTT
Keratin-based products for effective wound care management in superficial and partial thickness burns injuries
Burns from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZJxMuQ via IFTTT
Altered fMRI resting-state connectivity in individuals with fibromyalgia on acute pain stimulation
European Journal of Pain from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1WqqlmG via IFTTT
Patient characteristics associated with differences in admission frequency for diabetic ketoacidosis in United States children's hospitals
The Journal of Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Wqql6o via IFTTT
Awakening Following Cardiac Arrest: Determined by the Definitions Used or the Therapies DELIVERED?
Resuscitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1ZJxNyQ via IFTTT
The prevalence of alcohol-related trauma recidivism: a systematic review
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Wqql6b via IFTTT
The source of Mycobacterium tuberculosis-specific IFN-γ production in peripheral blood mononuclear cells of TB patients
Publication date: March 2016 *Source:*International Immunopharmacology, Volume 32 Author(s): Feng Wang, Lie Mao, Hongyan Hou, Shiji Wu, Min Huang, Botao Yin, Jing Huang, Qin Zhu, Yingying Pan, Ziyong Sun Mycobacterium tuberculosis (Mtb)-specific IFN-γ secretion plays important roles in anti-tuberculosis (TB) immunity. Mtb-specific IFN-γ response can be induced in HIV/TB co-infected patients with a low CD4 lymphocyte count; this suggests that the source of Mtb-specific IFN-γ production is not limited in CD4+ T lymphocytes. Currently, the major sources of Mtb-specific IFN-γ production... περισσότερα »
Quantitative changes of melanoma associated antigens as a biomarker for targeted therapy response
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1QkCw3Y via IFTTT
Transgenic mouse lines help decipher the roles of EGFR ligands in the skin
Abstract The epidermal growth factor receptor (EGFR/ERBB1), a prototypical tyrosine kinase receptor belonging to the ERBB family (ERBB1-ERBB4), has numerous critical roles during development, growth, and tissue homeostasis. Its essentially pro-proliferative actions are frequently exploited by tumor cells, and blocking the activity of the EGFR and of the related ERBB receptors with monoclonal antibodies or kinase inhibitors represents an important strategy for the therapy of various cancer types (1). Canonical activation of the EGFR involves binding by a ligand, induction of recepto... περισσότερα »
Differential expression of cancer stem cell markers in cutaneous and systemic lymphoma
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1JeRdEx via IFTTT
In situ chemical behaviour of methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) in reconstructed human epidermis: a new approach to the cross-reactivity issue
Summary Background Methylisothiazolinone (MI) [with methylchloroisothiazolinone (MCI) in a ratio of 1:3, a well-recognized allergenic preservative] was released as an individual preservative in the 2000s for industrial products and in 2005 for cosmetics. The high level of exposure to MI since then has provoked an epidemic of contact allergy to MI, and an increase in MI/MCI allergy. There are questions concerning the MI/MCI cross-reaction pattern. Objectives To bring a new perspective on the MI/MCI cross-reactivity issue by studying their *in situ* chemical behaviour in 3D reconst... περισσότερα »
Allergy risks with laptop computers – nickel and cobalt release
Summary Background Laptop computers may release nickel and cobalt when they come into contact with skin. Few computer brands have been studied. Objectives To evaluate nickel and cobalt release from laptop computers belonging to several brands by using spot tests, and to quantify the release from one new computer by using artificial sweat solution. Methods Nickel and cobalt spot tests were used on the lid and wrist supports of 31 laptop computers representing five brands. The same surfaces were tested on all computers. In addition, one new computer was bought and dismantled for ...περισσότερα »
Fragrance allergy could be missed without patch testing with 26 individual fragrance allergens
Summary Background In 2003, the EU Cosmetics Directive stated that 26 fragrance substances must be listed on the cosmetic product ingredient labels. Not all of these 26 fragrance substances are detected by the usual screening markers comprising fragrance mix I, fragrance mix II, and *Myroxylon pereirae*. Objectives To evaluate the usefulness of testing with the 26 individual fragrance substances in addition to the standard fragrance screening markers. Materials and Methods Three hundred and twelve consecutive patients were patch tested with our baseline series and the 26 specifi... περισσότερα »
WES in a family trio suggests involvement of TECPR2 in a complex form of progressive motor neuron disease
ABSTRACT We have performed whole exome sequencing in a family trio with a 16 year old girl suffering of progressive motor neuron disease. There was no family history of the disease and no parental consanguinity. Our exome analysis indicated the proband as a compound heterozygote for two missense variants in the TECPR2 gene according to a recessive mode of inheritance. The TECPR2 gene has been reported as a positive regulator of autophagy which is an essential mechanism for maintaining neuron homeostasis and survival and plays a key role in major adult and pediatric neurodegenerativ... περισσότερα »
Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP-activated kinase (AMPK). Here, we verified whether AMPK was involved in impaired β-cell function in islets from rats subjected to CR for 21 days. Eight-week-old male rats were distributed into a control (CTL) group that was fed an… Continue reading Reduced AMPKα2 protein expression restores glucose-induced insulin secretion in islets from calorie-restricted rats
Antibiotics, Vol. 5, Pages 8: Antimicrobial Stewardship for a Geriatric Behavioral Health Population
Antimicrobial resistance is a growing public health concern. Antimicrobial stewardship and multi-disciplinary intervention can prevent inappropriate antimicrobial use and improve patient care. Special populations, especially older adults and patients with mental health disorders, can be particularly in need of such intervention. The purpose of this project was to assess the impact of pharmacist intervention on… Continue reading Antibiotics, Vol. 5, Pages 8: Antimicrobial Stewardship for a Geriatric Behavioral Health Population
IJERPH, Vol. 13, Pages 140: Heart Rate, Stress, and Occupational Noise Exposure among Electronic Waste Recycling Workers
Electronic waste (e-waste) is a growing occupational and environmental health issue around the globe. E-waste recycling is a green industry of emerging importance, especially in low-and middle-income countries where much of this recycling work is performed, and where many people’s livelihoods depend on this work. The occupational health hazards of e-waste recycling have not been… Continue reading IJERPH, Vol. 13, Pages 140: Heart Rate, Stress, and Occupational Noise Exposure among Electronic Waste Recycling Workers
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