Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation [ALLERGY AND OTHER HYPERSENSITIVITIES]
Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation [ALLERGY AND OTHER HYPERSENSITIVITIES]: IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an influential role in asthma pathogenesis. We examined the role of IL-13 and IL-17A in mediating airway hyperresponsiveness (AHR), lung inflammation, and mucus metaplasia in a dual Th2/Th17 model of asthma. IL-13 and/or IL-17A were neutralized using mAbs. Th2/Th17 adoptive transfer induced a mixed asthma phenotype characterized by elevated eosinophilia and n... περισσότερα »
Dengue Virus Nonstructural Protein 1-Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation [INFECTIOUS DISEASE AND HOST RESPONSE]
Dengue Virus Nonstructural Protein 1-Induced Antibodies Cross-React with Human Plasminogen and Enhance Its Activation [INFECTIOUS DISEASE AND HOST RESPONSE]: Dengue virus (DENV) infection is the most common mosquito-borne viral disease, and it can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Abnormal activation of the coagulation and fibrinolysis system is one of the hallmarks of DHF/DSS. However, the mechanism underlying hemorrhage in DHF/DSS remains elusive. In previous studies, plasminogen (Plg) cross-reactive Abs, which can recognize DE... περισσότερα »
PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming [INFECTIOUS DISEASE AND HOST RESPONSE]
PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming [INFECTIOUS DISEASE AND HOST RESPONSE]: The challenging human pathogen *Staphylococcus aureus* has highly efficient immune evasion strategies for causing a wide range of diseases, from skin and soft tissue to life-threatening infections. Phenol-soluble modulin (PSM) peptides are major pathogenicity factors of community-associated methicillin-resistant *S. aureus* strains. In previous work, we demonstrated that PSMs in combination with TLR... περισσότερα »
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells
[TUMOR IMMUNOLOGY] by Younis, R. H., Han, K. L., Webb, T. J. via The Journal of Immunology current issue One of the mechanisms by which malignancies can induce immune suppression is through the production of cytokines that affect the maturation and differentiation of inflammatory cells in the tumor microenvironment. Semaphorin 4D (Sema4D) is a proangiogenic cytokine produced by several malignancies, which has been described in the regulation of the immune system. In the present study, we examined the role of human head and neck squamous cell carcinoma (HNSCC)–secreted Sema4D on myel... περισσότερα »
Secreted autoantibody repertoires in Sjögren's syndrome and systemic lupus erythematosus
: A proteomic approach via Autoimmunity Reviews Publication date: Available online 22 January 2016 *Source:*Autoimmunity Reviews Author(s): Mahmood A. Al Kindi, Alex D. Colella, Tim K. Chataway, Michael W. Jackson, Jing J. Wang, Tom P. Gordon The structures of epitopes bound by autoantibodies against RNA-protein complexes have been well-defined over several decades, but little is known of the clonality, immunoglobulin (Ig) variable (V) gene usage and mutational status of the autoantibodies themselves at the level of the secreted (serum) proteome. A novel proteomic workflow is presented... περισσότερα »
Systemic redox imbalance, chronic inflammatory status, respiratory bronchiolitis-associated interstitial lung disease-like lung disease, and erythrocyte morphology changes
Rett syndrome: An autoimmune disease? updated on Sun Jan 24, 2016 13:58 via Autoimmunity Reviews Publication date: Available online 22 January 2016 *Source:*Autoimmunity Reviews Author(s): Claudio De Felice, Silvia Leoncini, Cinzia Signorini, Alessio Cortelazzo, Paolo Rovero, Thierry Durand, Lucia Ciccoli, Anna Maria Papini, Joussef Hayek Rett syndrome (RTT) is a devastating neurodevelopmental disease, previously included into the autistic spectrum disorders, affecting almost exclusively females (frequency 1:10,000). RTT leads to intellective deficit, purposeful hands use loss and late... περισσότερα »
Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production
Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production via Allergy and Clinical Immunology Publication date: Available online 22 January 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Monika Majewska-Szczepanik, Philip W. Askenase, Francis M. Lobo, Katarzyna Marcińska, Li Wen, Marian Szczepanik BackgroundSubcutaneous allergen-specific immunotherapy is a standard route for the immunotherapy of allergic diseases. It modulates the course of allergy and can generate long-term remission. However, subcutaneous ... περισσότερα »
Blood eosinophils
: the Holy Grail for asthma phenotyping? by Merritt L. Fajt via Annals of Allergy, Asthma & Immunology Asthma has been generally defined as a chronic inflammatory disorder of the airways with bronchial hyperresponsiveness and reversible variable airflow obstruction, affecting 6% to 8% of the US population.1 For many years, the mainstay of therapy has been inhaled corticosteroids (ICSs) and systemic corticosteroids. However, not all individuals with asthma respond to these standard treatments. Approximately 5% to 10% of individuals with asthma can be classified as having severe asthma ...περισσότερα »
Evidence vs advocacy in the e-cigarette debate: to vape or not to vape, that is the question
Evidence vs advocacy in the e-cigarette debate: to vape or not to vape, that is the question: In the current issue of the Annals, Polosa et al1 advance the argument that the electronic cigarette (e-cigarette) may have a role in reducing the incontrovertible adverse health risks of the traditional cigarette in an active smoker and thus may be a potentially safer alternative in the tobacco-smoking patient with asthma. This review complements the authors' own notable pilot study in 18 smoking patients with asthma, which suggested an improvement in airway hyperresponsiveness, pulmonary ... περισσότερα »
How many systemic reactions to skin prick tests could be preventable in defined conditions?
How many systemic reactions to skin prick tests could be preventable in defined conditions?: We read with interest the article by Sellaturay et al1 that reported the results of a large study on the rate of systemic reactions after skin prick tests (SPTs) in allergy diagnosis. We concur that the SPT is a safe procedure when inhalant allergens are used compared with the use of food extracts or fresh foods or drugs, but other studies have been published on this topic.2–5 In fact, literature data and our clinical experience suggest that even SPTs might induce a generalized allergic reac... περισσότερα »
Classification of angioedema without wheals
Classification of angioedema without wheals: We read with interest the article by Azofra et al regarding off-label treatment of some patients with idiopathic nonhistaminergic acquired angioedema (InH-AAE) with omalizumab.1 Besides describing the response to omalizumab of some patients with InH-AAE, this article opens the discussion on the need to improve the classification of patients with angioedema without wheals.2
Gut microbiota and allergic disease in children
Gut microbiota and allergic disease in children: With the advancement of technologies for genomic sequencing and molecular biology, our understanding of the human gut microbiome structure, function, and relation to human health and disease is rapidly expanding. It is currently estimated that 500 to 1,000 different bacterial species inhabit the mature gastrointestinal tract, with bacterial cells ultimately outnumbering host cells 10-fold.1 The micro-organisms colonizing the gut perform different functions vital for human health, including processing of dietary constituents, regulatio... περισσότερα »
Allergy to grass : Pre-seasonal, subcutaneous immunotherapy
: a double-blinded, placebo-controlled study in elderly patients with an allergy to grass via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: February 2016 *Source:*Annals of Allergy, Asthma & Immunology, Volume 116, Issue 2 Author(s): Andrzej Bozek, Krzysztof Kolodziejczyk, Anna Krajewska-Wojtys, Jerzy Jarzab BackgroundThere is limited evidence indicating that specific immunotherapy in elderly patients is safe and effective.ObjectiveTo evaluate the safety and efficacy of pre-seasonal specific subcutaneous immunotherapy (SCIT) against grass pollen al... περισσότερα »
An explicit solution for calculating optimum spawning stock size from Ricker’s stock recruitment model
Stock-recruitment models have been used for decades in fisheries management as a means of formalizing the expected number of offspring that recruit to a fishery based on the number of parents. In particular, Ricker's stock recruitment model is widely used due to its flexibility and ease with which the parameters can be estimated. After model fitting, the spawning stock size that produces the maximum sustainable yield (SMSY) to a fishery, and the harvest corresponding to it (UMSY), are two of the most common biological reference points of interest to fisheries managers. However, to ... περισσότερα »
The feasibility and radiological features of sacral alar iliac fixation in an adult population: a 3D imaging study
Background: Surgical treatments for adult spinal deformities often include pelvic fixation, and the feasibility of sacral-2 alar iliac (S2AI) screw fixation has been shown previously. However, sometimes S2AI screw fixation cannot be applied due to the presence of an osteolytic lesion or trauma or because the biomechanical properties of only an S2AI screw is insufficient. Therefore, we questioned the feasibility of using sacral AI screws in other segments and determined whether S3AI and S4AI screws have the potential to be used for sacral fractures. The aim of this study was to inve... περισσότερα »
Molecular evidence for sediment nitrogen fixation in a temperate New England estuary
Primary production in coastal waters is generally nitrogen (N) limited with denitrification outpacing nitrogen fixation (N2-fixation). However, recent work suggests that we have potentially underestimated the importance of heterotrophic sediment N2-fixation in marine ecosystems. We used clone libraries to examine transcript diversity of nifH (a gene associated with N2-fixation) in sediments at three sites in a temperate New England estuary (Waquoit Bay, Massachusetts, USA) and compared our results to net sediment N2 fluxes previously measured at these sites. We observed nifH expres...περισσότερα »
Structural strength of cancellous specimens from bovine femur under cyclic compression
The incidence of osteoporotic fractures was estimated as nine million worldwide in 2000, with particular occurrence at the proximity of joints rich in cancellous bone. Although most of these fractures spontaneously heal, some fractures progressively collapse during the early post-fracture period. Prediction of bone fragility during progressive collapse following initial fracture is clinically important. However, the mechanism of collapse, especially the gradual loss of the height in the cancellous bone region, is not clearly proved. The strength of cancellous bone after yield stre... περισσότερα »
Dentistry Journal, Vol. 4, Pages 2: Tobacco, Alcohol and Drug Use among Dental Undergraduates at One UK University in 2015
The aim of this study was determine the prevalence of tobacco, alcohol and illicit substance use among dental undergraduates at one UK university in 2015. A cross-sectional survey of all 344 dental undergraduates using an anonymous self-report questionnaire was carried out. The response rate was 77%, of which 29% were male and 71% female. Tobacco smoking was reported by 23.6% of males and 12.2% of females, with only 1.6% of females reporting to smoke ≥10 cigarettes per day. Alcohol consumption was reported by 85.5% of males and 84% of females, and reported levels of alcohol consump... περισσότερα »
Sensors, Vol. 16, Pages 147: 3D Markov Process for Traffic Flow Prediction in Real-Time
Recently, the correct estimation of traffic flow has begun to be considered an essential component in intelligent transportation systems. In this paper, a new statistical method to predict traffic flows using time series analyses and geometric correlations is proposed. The novelty of the proposed method is two-fold: (1) a 3D heat map is designed to describe the traffic conditions between roads, which can effectively represent the correlations between spatially- and temporally-adjacent traffic states; and (2) the relationship between the adjacent roads on the spatiotemporal domain ...περισσότερα »
111In-encapsulated liposome-distribution in mouse xenografts of human ovarian cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23nlMyj via IFTTT
In This Issue
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23nlNlZ via IFTTT
Issue Information
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23nlLKS via IFTTT
Could testosterone link lead to therapy for psychopathy?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
People with psychopathy do not experience emotions as other people do; brain images suggest that testosterone levels could be a factor. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nJ0vyB via IFTTT
Could testosterone link lead to therapy for psychopathy?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
People with psychopathy do not experience emotions as other people do; brain images suggest that testosterone levels could be a factor. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nJ0vyB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
111In-encapsulated liposome-distribution in mouse xenografts of human ovarian cancer
from Cancer via ola Kala on Inoreader http://ift.tt/23nlMyj via IFTTT
In This Issue
from Cancer via ola Kala on Inoreader http://ift.tt/23nlNlZ via IFTTT
Issue Information
from Cancer via ola Kala on Inoreader http://ift.tt/23nlLKS via IFTTT
Adherence to the world cancer research fund/american institute for cancer research recommendations and breast cancer risk
Abstract The World Cancer Research Fund/American Association for Cancer Research (WCRF/AICR) has published 8 nutrition-related recommendations for the prevention of cancer. However, few prospective studies have examined these recommendations by breast cancer hormone receptor subtype and only one case-control study has included the dietary supplements recommendation in their evaluation. We investigated whether adherence to the WCRF/AICR cancer prevention recommendations was associated with breast cancer incidence, overall and by hormone receptor subtype, in the Swedish Mammography C... περισσότερα »
5-alpha reductase inhibitor use and prostate cancer survival in the Finnish Prostate Cancer Screening Trial
Abstract Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a cohort of 6,537 prostate cancer cases diagnosed in the Finnish Prostate Cancer Screening Trial and linked to the national prescription database for information on medication use. Cox proportional hazards regression was used to estimate hazard ratios and 95% co... περισσότερα »
Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity
Abstract The objective of this study was to determine whether genotyping of *MIR27A* polymorphisms rs895819A>G and rs11671784C>T can be used to improve the predictive value of *DPYD* variants to identify patients at risk of severe fluoropyrimidine-associated toxicity (FP-toxicity). Patients treated previously in a prospective study with fluoropyrimidine-based chemotherapy were genotyped for rs895819 and rs11671784, and *DPYD* c.2846A>T, c.1679T>G, c.1129-5923C>G, and c.1601G>A. The predictive value of *MIR27A* variants for early-onset grade ≥3 FP-toxicity, alone or in combination w... περισσότερα »
Biomarkers in bladder cancer: A metabolomic approach using in vitro and ex vivo model systems
Abstract Metabolomics has recently proved to be useful in the area of biomarker discovery for cancers in which early diagnostic and prognostic biomarkers are urgently needed, as is the case of bladder cancer (BC). This paper presents a comprehensive review of the literature on the metabolomic studies on BC, highlighting metabolic pathways perturbed in this disease and the altered metabolites as potential biomarkers for BC detection. Current disease model systems used in the study of BC metabolome include *in vitro* cultured cancer cells, *ex vivo* neoplastic bladder tissues, and b... περισσότερα »
Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 25 January 2016 *Source:*Trends in Cell Biology Author(s): Casper C. Hoogenraad, Anna Akhmanova Transport of different intracellular cargoes along cytoskeleton filaments is essential for the morphogenesis and function of a broad variety of eukaryotic cells. Intracellular transport is mediated by cytoskeletal motors including myosin, kinesin, and dynein, which are typically linked to various cargoes by adaptor proteins. Recent studies suggest that adaptor proteins can also act as essential transport cofactors, which control mot... περισσότερα »
Nuclear Mechanisms of Insulin Resistance
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 25 January 2016 *Source:*Trends in Cell Biology Author(s): Sona Kang, Linus T-Y. Tsai, Evan D. Rosen Insulin resistance is a sine qua non of type 2 diabetes and is associated with many other clinical conditions. Decades of research into mechanisms underlying insulin resistance have mostly focused on problems in insulin signal transduction and other mitochondrial and cytosolic pathways. By contrast, relatively little attention has been focused on transcriptional and epigenetic contributors to insulin resistance, despite strong ... περισσότερα »
Microglandular adenosis associated with triple-negative breast cancer is a neoplastic lesion of triple-negative phenotype harbouring TP53 somatic mutations
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Microglandular adenosis (MGA) is a rare proliferative lesion of the breast composed of small glands lacking myoepithelial cells and lined by S100-positive, oestrogen receptor (ER)-negative, progesterone receptor (PR)-negative and HER2-negative epithelial cells. There is evidence to suggest that MGA may constitute a non-obligate precursor of triple-negative breast cancer (TNBC). We sought to define the genomic landscape of pure MGA and atypical MGA (AMGA) {EdQ; Please ensure your meaning has been retained} and of associate... περισσότερα »
An explicit solution for calculating optimum spawning stock size from Ricker’s stock recruitment model
Stock-recruitment models have been used for decades in fisheries management as a means of formalizing the expected number of offspring that recruit to a fishery based on the number of parents. In particular, Ricker’s stock recruitment model is widely used due to its flexibility and ease with which the parameters can be estimated. After model… Continue reading An explicit solution for calculating optimum spawning stock size from Ricker’s stock recruitment model
The feasibility and radiological features of sacral alar iliac fixation in an adult population: a 3D imaging study
Background: Surgical treatments for adult spinal deformities often include pelvic fixation, and the feasibility of sacral-2 alar iliac (S2AI) screw fixation has been shown previously. However, sometimes S2AI screw fixation cannot be applied due to the presence of an osteolytic lesion or trauma or because the biomechanical properties of only an S2AI screw is insufficient.… Continue reading The feasibility and radiological features of sacral alar iliac fixation in an adult population: a 3D imaging study
Molecular evidence for sediment nitrogen fixation in a temperate New England estuary
Primary production in coastal waters is generally nitrogen (N) limited with denitrification outpacing nitrogen fixation (N2-fixation). However, recent work suggests that we have potentially underestimated the importance of heterotrophic sediment N2-fixation in marine ecosystems. We used clone libraries to examine transcript diversity of nifH (a gene associated with N2-fixation) in sediments at three sites in… Continue reading Molecular evidence for sediment nitrogen fixation in a temperate New England estuary
Structural strength of cancellous specimens from bovine femur under cyclic compression
The incidence of osteoporotic fractures was estimated as nine million worldwide in 2000, with particular occurrence at the proximity of joints rich in cancellous bone. Although most of these fractures spontaneously heal, some fractures progressively collapse during the early post-fracture period. Prediction of bone fragility during progressive collapse following initial fracture is clinically important. However,… Continue reading Structural strength of cancellous specimens from bovine femur under cyclic compression
Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue
Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed, paraffin embedded tissue (FFPE). This study identified a set of antibodies for investigating the immunopathology of infectious CNS diseases in… Continue reading Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue
Biosensors, Vol. 6, Pages 4: Variation in Gas and Volatile Compound Emissions from Human Urine as It Ages, Measured by an Electronic Nose
The medical profession is becoming ever more interested in the use of gas-phase biomarkers for disease identification and monitoring. This is due in part to its rapid analysis time and low test cost, which makes it attractive for many different clinical arenas. One technology that is showing promise for analyzing these gas-phase biomarkers is the… Continue reading Biosensors, Vol. 6, Pages 4: Variation in Gas and Volatile Compound Emissions from Human Urine as It Ages, Measured by an Electronic Nose
Full-Thickness Burns Infected with Staphylococcus aureus or Pseudomonas Aeruginosa Can Be Effectively Treated with Topical Antibiotics
Full-Thickness Porcine Burns Infected with Staphylococcus aureus or Pseudomonas Aeruginosa Can Be Effectively Treated with Topical Antibiotics: Abstract Burn and blast injuries are frequently complicated by invasive infections, which lead to poor wound healing, delay in treatment, disability, or death. Traditional approach centers on early debridement, fluid resuscitation, and adjunct intravenous antibiotics. These modalities often… Continue reading Full-Thickness Burns Infected with Staphylococcus aureus or Pseudomonas Aeruginosa Can Be Effectively Treated with Topical Antibiotics
Sensors, Vol. 16, Pages 147: 3D Markov Process for Traffic Flow Prediction in Real-Time
Recently, the correct estimation of traffic flow has begun to be considered an essential component in intelligent transportation systems. In this paper, a new statistical method to predict traffic flows using time series analyses and geometric correlations is proposed. The novelty of the proposed method is two-fold: (1) a 3D heat map is designed to… Continue reading Sensors, Vol. 16, Pages 147: 3D Markov Process for Traffic Flow Prediction in Real-Time
Many colorectal cancer patients are younger than the recommended screening age – should we start screening younger? https://t.co/YQ6nXjH1OI
Many colorectal cancer patients are younger than the recommended screening age – should we start screening younger? https://t.co/YQ6nXjH1OI from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/691546605380575232 via IFTTT
Administrative Sciences, Vol. 6, Pages 2: Acknowledgement to Reviewers of Administrative Sciences in 2015
The editors of Administrative Sciences would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. […] from #Medicine via ola Kala on Inoreader http://ift.tt/1lJCru0 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nj0Fwh via IFTTT
Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 19 δευτερόλεπτα
Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts: Abstract Introduction Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication of bisphosphonate therapy. The mechanism underlying BRONJ pathogenesis is poorly understood. Objectives To determine the effects of zoledronic acid (ZA) and geranylgeraniol (GGOH) on the […]
Malocclusion in the primary dentition in children with and without deformational plagiocephaly
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 19 δευτερόλεπτα
Malocclusion in the primary dentition in children with and without deformational plagiocephaly: Abstract Objectives Asymmetries of the jaw and orthodontic abnormalities are suspected as long-term consequences of positional cranial deformity. But only few data exist on this issue. As plagiocephaly is a common problem in infancy, potential functional impairments should be investigated to initiate appropriate […]
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 19 δευτερόλεπτα
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw: Abstract Objectives The aim of this study was to investigate the potential role of microcrack accumulation in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) through an animal model. Materials and methods Twenty-four ovariectomized rats were randomly divided into a bisphosphonate group […]
Effects of two different post-surgical protocols including either 0.05 % chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 19 δευτερόλεπτα
Effects of two different post-surgical protocols including either 0.05 % chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement: Abstract Objectives The aim of this study was to compare early wound healing, tooth staining and patient acceptance with two different […]
Warning signs for primary immunodeficiency disease : The 6 ESID warning signs for ADULT primary immunodeficiency diseases.10 Warning Signs of PID
The 6 ESID warning signs for ADULT primary immunodeficiency diseases 1. *Four or more infections requiring antibiotics within one year (otitis, bronchitis, sinusitis, pneumonia)* 2. *Recurring infections or infection requiring prolonged antibiotic therapy* 3. *Two or more severe bacterial infections (osteomyelitis, meningitis, septicemia, cellulitis)* 4. *Two or more radiologically proven pneumonia within 3 years* 5. *Infection with unusual localization or unusual pathogen* 6. *PID in the family* *10 Warning Signs of PID* *1) Four or more new ear... περισσότερα »
Table of Contents, Volume 170A, Number 2, February 2016
from Genes via ola Kala on Inoreader http://ift.tt/1WJjPYv via IFTTT
Children with developmental delays rarely referred to geneticists
from Genes via ola Kala on Inoreader http://ift.tt/1WJjOnu via IFTTT
In this issue
from Genes via ola Kala on Inoreader http://ift.tt/1WJjPHO via IFTTT
Anisakis simplex hypersensitivity and allergy
High prevalence of Anisakis simplex hypersensitivity and allergy in Sicily, Italy via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: February 2016 *Source:*Annals of Allergy, Asthma & Immunology, Volume 116, Issue 2 Author(s): Enrico Heffler, Maria Eva Sberna, Stefania Sichili, Rossella Intravaia, Giuliana Nicolosi, Morena Porto, Maria Teresa Liuzzo, Giuseppe Picardi, Silvia Fichera, Nunzio Crimi BackgroundAnisakis simplex can elicit allergic reactions when ingested in raw or marinated fish. The prevalence of A simplex hypersensitivity and allergy i... περισσότερα »
Intrapartum antibiotic exposure for group B Streptococcus treatment did not increase penicillin allergy in children
Intrapartum antibiotic exposure for group B Streptococcus treatment did not increase penicillin allergy in children via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: February 2016 *Source:*Annals of Allergy, Asthma & Immunology, Volume 116, Issue 2 Author(s): Sara M. May, Martha F. Hartz, Avni Y. Joshi, Miguel A. Park BackgroundGroup B Streptococcus (GBS) is the leading infectious cause of neonatal morbidity and mortality in the United States. Intrapartum administration of antibiotics to mothers with positivity to GBS is performed for prevention, wi... περισσότερα »
Asthma, oculonasal symptoms, and skin test sensitivity
across National Health and Nutrition Examination Surveys via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: February 2016 *Source:*Annals of Allergy, Asthma & Immunology, Volume 116, Issue 2 Author(s): Qingyu Meng, Sairaman Nagarajan, Yeongkwon Son, Panagiotis Koutsoupias, Leonard Bielory BackgroundThe increasing prevalence of allergies and asthma has been reported. However, the progression of the prevalence of allergy (the “allergic diathesis progression”) has not been examined over time from skin test positivity to oculonasal symptoms to the devel... περισσότερα »
Dentistry Journal, Vol. 4, Pages 2: Tobacco, Alcohol and Drug Use among Dental Undergraduates at One UK University in 2015
The aim of this study was determine the prevalence of tobacco, alcohol and illicit substance use among dental undergraduates at one UK university in 2015. A cross-sectional survey of all 344 dental undergraduates using an anonymous self-report questionnaire was carried out. The response rate was 77%, of which 29% were male and 71% female. Tobacco smoking was reported by 23.6% of males and 12.2% of females, with only 1.6% of females reporting to smoke ≥10 cigarettes per day. Alcohol consumption was reported by 85.5% of males and 84% of females, and reported levels of alcohol consump... περισσότερα »
Experimental modulation of external microbiome affects nestmate recognition in harvester ants (Pogonomyrmex barbatus)
Social insects use odors as cues for a variety of behavioral responses, including nestmate recognition. Past research on nestmate recognition indicates cuticular hydrocarbons are important nestmate discriminators for social insects, but other factors are likely to contribute to colony-specific odors. Here we experimentally tested whether external microbes contribute to nestmate recognition in red harvester ants (Pogonomyrmex barbatus). We changed the external microbiome of ants through topical application of either antibiotics or microbial cultures. We then observed behavior of ne... περισσότερα »
First insights into the diversity of gill monogeneans of ‘Gnathochromis’ and Limnochromis (Teleostei, Cichlidae) in Burundi: do the parasites mirror host ecology and phylogenetic history?
Monogenea is one of the most species-rich groups of parasitic flatworms worldwide, with many species described only recently, which is particularly true for African monogeneans. For example, Cichlidogyrus, a genus mostly occurring on African cichlids, comprises more than 100 nominal species. Twenty-two of these have been described from Lake Tanganyika, a famous biodiversity hotspot in which many vertebrate and invertebrate taxa, including monogeneans, underwent unique and spectacular radiations. Given their often high degrees of host specificity, parasitic monogeneans were also us... περισσότερα »
Age-related changes of dental pulp tissue after experimental tooth movement in rats
It is generally accepted that the effect of orthodontic tooth movement on the dental pulp in adolescents is reversible and that it has no long-lasting effect on pulpal physiology. However, it is not clear yet if the same conclusion is also valid for adult subjects. Thus, in two groups of rats, aged 6 and 40 weeks respectively, 3 molars at one side of the maxilla were moved together in a mesial direction with a standardized orthodontic appliance delivering a force of 10 cN. The contralateral side served as a control. Parasagittal histological sections were prepared after tooth move... περισσότερα »
Isolation and characterization of eight polymorphic microsatellites for the spotted spiny lobster, Panulirus guttatus
Microsatellite sequences were isolated from enriched genomic libraries of the spotted spiny lobster, Panulirus guttatus using 454 pyrosequencing. Twenty-nine previously developed polymerase chain reaction primer pairs of Panulirus argus microsatellite loci were also tested for cross-species amplification in Panulirus guttatus. In total, eight consistently amplifying, and polymorphic loci were characterized for 57 individuals collected in the Florida Keys and Bermuda. The number of alleles per locus ranged from 8 to 20 and observed heterozygosities ranged from 0.409 to 0.958. Signi...περισσότερα »
An explicit solution for calculating optimum spawning stock size from Ricker’s stock recruitment model
Stock-recruitment models have been used for decades in fisheries management as a means of formalizing the expected number of offspring that recruit to a fishery based on the number of parents. In particular, Ricker's stock recruitment model is widely used due to its flexibility and ease with which the parameters can be estimated. After model fitting, the spawning stock size that produces the maximum sustainable yield (SMSY) to a fishery, and the harvest corresponding to it (UMSY), are two of the most common biological reference points of interest to fisheries managers. However, to ... περισσότερα »
The feasibility and radiological features of sacral alar iliac fixation in an adult population: a 3D imaging study
Background: Surgical treatments for adult spinal deformities often include pelvic fixation, and the feasibility of sacral-2 alar iliac (S2AI) screw fixation has been shown previously. However, sometimes S2AI screw fixation cannot be applied due to the presence of an osteolytic lesion or trauma or because the biomechanical properties of only an S2AI screw is insufficient. Therefore, we questioned the feasibility of using sacral AI screws in other segments and determined whether S3AI and S4AI screws have the potential to be used for sacral fractures. The aim of this study was to inve... περισσότερα »
Molecular evidence for sediment nitrogen fixation in a temperate New England estuary
Primary production in coastal waters is generally nitrogen (N) limited with denitrification outpacing nitrogen fixation (N2-fixation). However, recent work suggests that we have potentially underestimated the importance of heterotrophic sediment N2-fixation in marine ecosystems. We used clone libraries to examine transcript diversity of nifH (a gene associated with N2-fixation) in sediments at three sites in a temperate New England estuary (Waquoit Bay, Massachusetts, USA) and compared our results to net sediment N2 fluxes previously measured at these sites. We observed nifH expres...περισσότερα »
Structural strength of cancellous specimens from bovine femur under cyclic compression
The incidence of osteoporotic fractures was estimated as nine million worldwide in 2000, with particular occurrence at the proximity of joints rich in cancellous bone. Although most of these fractures spontaneously heal, some fractures progressively collapse during the early post-fracture period. Prediction of bone fragility during progressive collapse following initial fracture is clinically important. However, the mechanism of collapse, especially the gradual loss of the height in the cancellous bone region, is not clearly proved. The strength of cancellous bone after yield stre... περισσότερα »
Immunohistochemistry for the detection of neural and inflammatory cells in equine brain tissue
Phenotypic characterization of cellular responses in equine infectious encephalitides has had limited description of both peripheral and resident cell populations in central nervous system (CNS) tissues due to limited species-specific reagents that react with formalin-fixed, paraffin embedded tissue (FFPE). This study identified a set of antibodies for investigating the immunopathology of infectious CNS diseases in horses. Multiple commercially available staining reagents and antibodies derived from antigens of various species for manual immunohistochemistry (IHC) were screened. S... περισσότερα »
Sensors, Vol. 16, Pages 147: 3D Markov Process for Traffic Flow Prediction in Real-Time
Recently, the correct estimation of traffic flow has begun to be considered an essential component in intelligent transportation systems. In this paper, a new statistical method to predict traffic flows using time series analyses and geometric correlations is proposed. The novelty of the proposed method is two-fold: (1) a 3D heat map is designed to describe the traffic conditions between roads, which can effectively represent the correlations between spatially- and temporally-adjacent traffic states; and (2) the relationship between the adjacent roads on the spatiotemporal domain ...περισσότερα »
Administrative Sciences, Vol. 6, Pages 2: Acknowledgement to Reviewers of Administrative Sciences in 2015
The editors of Administrative Sciences would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1lJCru0 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Capsaicin in autoimmune diseases
Some like it HOT: The emerging role of spicy foo→(capsaicin) in autoimmune diseases via Autoimmunity Reviews Publication date: Available online 23 January 2016 *Source:*Autoimmunity Reviews Author(s): Yaxiong Deng, Xin Huang, Haijing Wu, Ming Zhao, Qianjin Lu, Eitan Israeli, Shani Dahan, Miri Blank, Yehuda Shoenfeld Autoimmune diseases refer to a spectrum of diseases characterized by an active immune response against the host, which frequently involves increased autoantibody production. The pathogenesis of autoimmune diseases is multifactorial and the exploitation of novel effective tr... περισσότερα »
Allergic Fungal Rhinosinusitis
Allergic Fungal Rhinosinusitis: A Study in a Tertiary Care Hospital in India: The study was conducted to study the occurrence and clinical presentation of allergic fungal rhinosinusitis (AFRS), characterize the same, and correlate with the microbiological profile. Clinically suspected cases of fungal rhinosinusitis (FRS) depending upon their clinical presentation, nasal endoscopy, and radiological evidences were included. Relevant clinical samples were collected and subjected to direct microscopy and culture and histopathological examination. 35 patients were diagnosed to have AFRS.... περισσότερα »
Patch esophagoplasty with a free proximal lateral leg flap for focal stricture of the cervical esophagus: A case report
Patch esophagoplasty with a free proximal lateral leg flap for focal stricture of the cervical esophagus: A case report: Esophageal stricture after surgery or trauma is a major reason for poor oral nutrition, body-weight loss, and general damage to health. Patch esophagoplasty, after repeated failed dilation attempts, is recommended for focal esophageal strictures. In this report, we present a case in which a free proximal lateral leg flap was used for reconstruction of focal stricture of the cervical esophagus. A 62-year-old man developed progressive dysphagia after hypopharyngeal... περισσότερα »
Full-Thickness Burns Infected with Staphylococcus aureus or Pseudomonas Aeruginosa Can Be Effectively Treated with Topical Antibiotics
Full-Thickness Porcine Burns Infected with Staphylococcus aureus or Pseudomonas Aeruginosa Can Be Effectively Treated with Topical Antibiotics: [image: cover.gif?v=1&s=4e06cdb9cbac42b01d5dfc71] Abstract Burn and blast injuries are frequently complicated by invasive infections, which lead to poor wound healing, delay in treatment, disability, or death. Traditional approach centers on early debridement, fluid resuscitation, and adjunct intravenous antibiotics. These modalities often prove inadequate in burns, where compromised local vasculature limits the tissue penetration of sys... περισσότερα »
Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts
Effects of zoledronic acid and geranylgeraniol on the cellular behaviour and gene expression of primary human alveolar osteoblasts: Abstract IntroductionBisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication of bisphosphonate therapy. The mechanism underlying BRONJ pathogenesis is poorly understood. ObjectivesTo determine the effects of zoledronic acid (ZA) and geranylgeraniol (GGOH) on the mevalonate pathway (MVP) in osteoblasts generated from the human mandibular alveolar bone in terms of cell viability/proliferation, migration, apoptosis and gene e... περισσότερα »
Malocclusion in the primary dentition in children with and without deformational plagiocephaly
Malocclusion in the primary dentition in children with and without deformational plagiocephaly: Abstract ObjectivesAsymmetries of the jaw and orthodontic abnormalities are suspected as long-term consequences of positional cranial deformity. But only few data exist on this issue. As plagiocephaly is a common problem in infancy, potential functional impairments should be investigated to initiate appropriate measures if necessary. The aim of our study was to compare the orthodontic situation in primary dentition of children with positional plagiocephaly and children without cranial d... περισσότερα »
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw
Role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw: Abstract ObjectivesThe aim of this study was to investigate the potential role of microcrack accumulation in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) through an animal model. Materials and methodsTwenty-four ovariectomized rats were randomly divided into a bisphosphonate group (*n* = 19) and control group (*n* = 5) and weekly injected with zoledronic acid and normal saline, respectively. After 6 weeks, surgical intervention was performed, and the injectio... περισσότερα »
Sensors, Vol. 16, Pages 149: Improved Circuits with Capacitive Feedback for Readout Resistive Sensor Arrays
One of the most suitable ways of distributing a resistive sensor array for reading is an array with M rows and N columns. This allows reduced wiring and a certain degree of parallelism in the implementation, although it also introduces crosstalk effects. Several types of circuits can carry out the analogue-digital conversion of this type of sensors. This article focuses on the use of operational amplifiers with capacitive feedback and FPGAs for this task. Specifically, modifications of a previously reported circuit are proposed to reduce the errors due to the non-idealities of the ... περισσότερα »
Sensors, Vol. 16, Pages 151: Evaluation of the Bitterness of Traditional Chinese Medicines using an E-Tongue Coupled with a Robust Partial Least Squares Regression Method
To accurately, safely, and efficiently evaluate the bitterness of Traditional Chinese Medicines (TCMs), a robust predictor was developed using robust partial least squares (RPLS) regression method based on data obtained from an electronic tongue (e-tongue) system. The data quality was verified by the Grubb's test. Moreover, potential outliers were detected based on both the standardized residual and score distance calculated for each sample. The performance of RPLS on the dataset before and after outlier detection was compared to other state-of-the-art methods including multivaria... περισσότερα »
Effects of two different post-surgical protocols including either 0.05 % chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement
Effects of two different post-surgical protocols including either 0.05 % chlorhexidine herbal extract or 0.1 % chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement: Abstract ObjectivesThe aim of this study was to compare early wound healing, tooth staining and patient acceptance with two different post-surgical maintenance protocols. Materials and methodsForty patients scheduled for flap surgery to treat periodontal pockets or accommodate dental implants were randomly assigned to ... περισσότερα »
Augmented reality visualization in head and neck surgery: an overview of recent findings in sentinel node biopsy and future perspectives
Augmented reality visualization in head and neck surgery: an overview of recent findings in sentinel node biopsy and future perspectives: “Augmented reality visualisation”, in which the site of an operation is merged with computer-generated graphics, provides a way to view the relevant part of the patient's body in better detail. We describe its role in relation to sentinel lymph node biopsy (SLNB), current advancements, and future directions in the excision of tumours in early-stage cancers of the head and neck.
Immediate effects of electronic cigarettes on perfusion in buccal mucosal tissue
Do you mind if I vape? Immediate effects of electronic cigarettes on perfusion in buccal mucosal tissue - a pilot study Abstract The association between smoking and postoperative complications is compounded in patients who have oral and maxillofacial operations by an additional local effect, and patients often continue to smoke after operation despite advice to stop. Recent studies have suggested that nicotine may reduce inflammation and improve angiogenesis, so topical application may be beneficial for smokers. The electronic cigarette is increasing in popularity and more patien...περισσότερα »
Assault-Related Facial Injuries
During the Season of Goodwill via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 22 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Shofiq Islam, Nosa Uwadiae, Jonathan P. Hayter AimThe objective of this study was to assess if the season of goodwill manifests in a reduction in the rate of presentations of maxillofacial injuries secondary to interpersonal violence over the 12-days of Christmas.Materials & MethodsWe performed a retrospective analysis at a UK teaching hospital. We identifie... περισσότερα »
PI3K/AKT and RAS/RAF pathway activation in malignant salivary gland tumours
Mutational analysis of PI3K/AKT and RAS/RAF pathway activation in malignant salivary gland tumours with a new mutation of PIK3CA via Oral and Maxillofacial Surgery Publication date: Available online 22 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): B. Shalmon, M. Drendel, M. Wolf, A. Hirshberg, Y. Cohen The phosphoinositide 3-kinase (PIK3)/v-akt murine thymoma (AKT) oncogene pathway and the RAS/RAF pathway are involved in regulating the signalling of multiple biological processes, including apoptosis, metabolism, cell proliferation, and cell gro...περισσότερα »
Shaving the zygomatic process during reduction malarplasty
The importance of via Oral and Maxillofacial Surgery Publication date: Available online 22 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): T.S. Lee Reduction malarplasty surgery has become increasingly popular in recent years, especially in many East Asian countries. This is, in part, because many Asians consider a small, smooth, and feminine face to be more attractive and aesthetically desirable. Among the various reduction malarplasty methods, the L-shaped osteotomy technique, through intraoral and sideburn incisions, is now one of the most ... περισσότερα »
Surgical margins in oral cavity cancer
High-volume surgeons deliver larger via Oral and Maxillofacial Surgery Publication date: Available online 22 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Owen G. Ellis, Michael C. David, Daniel J. Park, Martin D. Batstone PurposeMany factors are involved in oral cavity cancer surgery, and their association with the surgical margin; thus, patient outcomes are still not completely understood. This aim of this study was to determine which variable or variables had the greatest influence on increasing the size of the surgical margin.MethodsA retrospective coh...περισσότερα »
Many colorectal cancer patients are younger than the recommended screening age – should we start screening younger? https://t.co/YQ6nXjH1OI
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Many colorectal cancer patients are younger than the recommended screening age – should we start screening younger? https://t.co/YQ6nXjH1OI from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/691546605380575232 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A live Caesarean section: ‘You don’t see this on Grey’s Anatomy’ – Irish Times
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Irish Times A live Caesarean section: ‘You don’t see this on Grey’s Anatomy’ Irish Times He also tells students of the more challenging side of surgery, such as complicated pregnancies that can involve operations of up to six hours, or dealing with very difficult cases involving cancer. For the students, this is day two of […]
An improved preparation method for cross-sectional TEM specimens of films deposited on metallic substrates
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
ABSTRACT Cross-sectional TEM analysis is one of the most important techniques to characterize microstructures of films. However, the complex process, low efficiency, and low success rate of specimen preparation limit its application. This paper analyzed the main causes of low success rate and proposed an improved method for specimen preparation of films deposited on metallic […]
Electron microscopic visualization of complementary labeled DNA with platinum-containing guanine derivative
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
ABSTRACT The object of the present report is to provide a method for a visualization of DNA in TEM by complementary labeling of cytosine with guanine derivative, which contains platinum as contrast-enhanced heavy element. The stretched single-chain DNA was obtained by modifying double-stranded DNA. The labeling method comprises the following steps: (i) stretching and adsorption […]
Adherence to the world cancer research fund/american institute for cancer research recommendations and breast cancer risk
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Abstract The World Cancer Research Fund/American Association for Cancer Research (WCRF/AICR) has published 8 nutrition-related recommendations for the prevention of cancer. However, few prospective studies have examined these recommendations by breast cancer hormone receptor subtype and only one case-control study has included the dietary supplements recommendation in their evaluation. We investigated whether adherence to the […]
5-alpha reductase inhibitor use and prostate cancer survival in the Finnish Prostate Cancer Screening Trial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Abstract Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a cohort of 6,537 prostate cancer cases diagnosed in […]
Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Abstract The objective of this study was to determine whether genotyping of MIR27A polymorphisms rs895819A>G and rs11671784C>T can be used to improve the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity (FP-toxicity). Patients treated previously in a prospective study with fluoropyrimidine-based chemotherapy were genotyped for rs895819 and rs11671784, and […]
Biomarkers in bladder cancer: A metabolomic approach using in vitro and ex vivo model systems
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Abstract Metabolomics has recently proved to be useful in the area of biomarker discovery for cancers in which early diagnostic and prognostic biomarkers are urgently needed, as is the case of bladder cancer (BC). This paper presents a comprehensive review of the literature on the metabolomic studies on BC, highlighting metabolic pathways perturbed in this […]
Apo-lipoproteins, lipids and risk of cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Abstract The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and Cancer Study, […]
Corrigendum
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1ZMGvXG via IFTTT
Cisplatin chemotherapy on the osseointegration of titanium implants
Effects of via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 22 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Haytham Al-Mahalawy, Hesham F. Marei, Hatem Abuohashish, Hussain Alhawaj, Munir Alrefaee, Badr Al-Jandan PurposeThe effect of chemotherapy on the osseointegration of dental implants has received less interest compared with radiotherapy. Thus, the aim of the current study was to investigate the effect of cisplatin chemotherapy on the osseointegration of dental implants in a rabbit model.Materials...περισσότερα »
Zygomatic Implants
Maxillary “All-On-Four” treatment using zygomatic implants. A mechanical analysis via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 23 January 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): P.H. de Moraes, S. Olate, M. de Arruda Nóbilo, L. Asprino, M. de Moraes, J. de Albergaría Barbosa ObjectiveZygomatic implants may be used for dental rehabilitation in atrophic maxillae. The aim of this study was to establish experimentally the areas of stress distribution using 2 kinds... περισσότερα »
Ranulas à expression cervicale
. Mise au point via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 22 January 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): P. Pouzoulet, C. Collet, J.M. Foletti, L. Guyot, C. Chossegros IntroductionLa ranula est un pseudo-kyste de la glande sublinguale (GSL) de cause souvent inconnue. Rarement, elle peut s’étendre au niveau cervical lorsqu’elle franchit le muscle mylo-hyoïdien. Le diagnostic des ranulas cervicales n’est pas toujours simple à établir, d’autres affections ... περισσότερα »
Une tuméfaction sublinguale chez un nourrisson
Une tuméfaction sublinguale chez un nourrisson via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 22 January 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): A. El Bousaadani, L. Eljahd, R. Abada, S. Rouadi, M. Roubal, M. Mahtar [image: Coupes scannographiques transversales objectivant une formation kystique du ...]
Dacryocystocèles congénitales
: traitement chirurgical ou simple surveillance ? via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 23 January 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): A. Hitter, E. Lamblin, B. Morand, A. Bertolo, I. Atallah, C.A. Righini IntroductionLes dacryocystocèles congénitales sont des pathologies rares et souvent méconnues. Leur traitement consiste, selon les équipes, en une simple surveillance, un sondage des voies lacrymales ou un drainage chirurgical par voie endonasale...περισσότερα »
Dental infection by Gemella morbillorum : Lemierre Syndrome: Headache and Proptosis
Lemierre syndrome: headache and proptosis as unusual presentation of dental infection by Gemella morbillorum via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 23 January 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): David González Ballester, Manuel Moreno-Sánchez, Raúl González-García, Florencio Monje Gil *Gemella morbillorum* From Wikipedia, the free encyclopedia *Gemella morbillorum*Scientific classificationKingdom:BacteriaPhylum: FirmicutesClass:BacilliOrder:BacillalesGenus:*Gemella*Species:*G. morbillorum*Binomial na... περισσότερα »
Management and prevention of acute bleedings in the head and neck area with interventional radiology
Management and prevention of acute bleedings in the head and neck area with interventional radiology: Background: The Interventional Neuroradiology is becoming more important in the interdisciplinary treatment of acute haemorrhages due to vascular erosion and vascular tumors in the head and neck area. The authors report on acute extracranial haemorrhage in emergency situations but also on preventive embolization of good vascularized tumors preoperatively and their outcome. Methods: Retrospective analysis of 52 patients, who underwent an interdisciplinary approach of the ORL Department...περισσότερα »
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: which method has more benefit on clinic?
Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Aylin Eryilmaz, Yesim Basal from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PwF3mJ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Se47E7 via IFTTT
Congenital nasal pyriform aperture stenosis: Elaboration of a management algorithm from 25 years of experience
Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): E. Moreddu, C. L.E. Treut-Gay, J.M. Triglia, R. Nicollas IntroductionCongenital nasal pyriform aperture stenosis (CNPAS) is a rare disease presenting with neonatal respiratory distress, often associated with other anomalies.Materials and methodsThis study reports the clinical and radiological characteristics of the patients managed in The Department of Pediatric Otolaryngology Head and Neck Surgery of La Timone Children’s Hospital in Marseille between 1988 and...περισσότερα »
Histopathological comparison of the onset of peri-implantitis and periodontitis in rats
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] AbstractBackground and objective There are a few experimental models that clearly describe the pathological differences in tissue destruction between periodontitis and peri-implantitis. We recently reported that the formation of immune complexes accelerates site-specific loss of attachment and alveolar bone resorption when an antigen is topically applied in the gingival sulcus of an immunized rat. We applied this model to the peri-implant tissues and compared peri-implant destruction to periodontitis without using a ligature. Materi... περισσότερα »
Early Candidate Biomarkers of Non-Small Cell Lung Cancer Are Screened and Identified in Premalignant Lung Lesions
A specific protein profile that accompanies neoplastic transformation in the premalignant airway epithelium could provide an opportunity for early diagnosis of lung cancer. The aim of this study was to screen and identify early candidate biomarkers of non–small cell lung cancer. Thirteen non–small cell lung cancer samples were obtained within 30 minutes after a surgical resection. Laser capture microdissection was performed to enrich the normal lung cell and squamous metaplasia or atypical adenomatous hyperplasia cell populations. The resulting tandem mass spectrum was automatical... περισσότερα »
Bevacizumab, temozolomide, and radiotherapy for newly diagnosed glioblastoma: comprehensive safety results during and after first-line therapy
Background The proposed use of bevacizumab with radiotherapy/temozolomide for newly diagnosed glioblastoma raised potential safety concerns. Bevacizumab has been linked with stroke, bleeding events, and wound-healing complications in other tumor types; these events are of particular concern for glioblastoma (highly vascular tumors that are usually resected). Published data on the interaction of bevacizumab with radiotherapy/temozolomide are also limited. We report safety data from a phase III randomized trial (Avastin in Glioblastoma), focusing on these considerations. Methods E... περισσότερα »
A time and motion study of subcutaneous versus intravenous trastuzumab in patients with HER2-positive early breast cancer
Abstract Within PrefHer (NCT01401166), patients and healthcare professionals (HCPs) preferred subcutaneous (SC) over intravenous (IV) trastuzumab. We undertook a prospective, observational time and motion study to quantify patients’ time in infusion chairs and active HCP time in PrefHer. Patients with HER2-positive early breast cancer received four adjuvant cycles of SC trastuzumab (600 mg fixed dose via SC single-use injection device [SID, Cohort 1] or SC handheld syringe [HHS, Cohort 2]) then four cycles of standard IV trastuzumab or the reverse sequence. Generic case report forms...περισσότερα »
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues
Abstract Renal pacemaker activity triggers peristaltic upper urinary tract contractions that propel waste from the kidney to the bladder, a process prone to congenital defects that are the leading cause of pediatric kidney failure. Recently, studies have discovered that hyperpolarization-activated cation (HCN) and T-type calcium (TTC) channel conductances underlie murine renal pacemaker activity, setting the origin and frequency and coordinating upper urinary tract peristalsis. Here, we determined whether this ion channel expression is conserved in the porcine and human urinary trac... περισσότερα »
Prognostic factors in alveolar soft part sarcoma: A SEER analysis
Objectives We reviewed the clinical characteristics and outcomes of patients treated for alveolar soft part sarcoma (ASPS) and analyzed the effect of surgery for patients presenting with and without metastatic disease (DM). Methods The SEER Registry was queried for patients with ASPS from 1973–2012. The Kaplan–Meier estimate and Cox proportional hazards were used to analyze survival outcomes and risk variables. Results Among 251 patients, 43% had DM and 67% locoregional disease (LR) on presentation. The 5-year overall survival (OS) for all patients was 56% (82% and 27% for LR and D...περισσότερα »
Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks
Publication date: May 2016 *Source:*International Journal of Biological Macromolecules, Volume 86 Author(s): Rania A. Hashad, Rania A.H. Ishak, Sherif Fahmy, Samar Mansour, Ahmed S. Geneidi At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable particle flocculation. Prepared formulations were characterized in terms of particle size (PS), zeta potential (ZP) and percentage yield (% yield). Artificial neural networks (ANN) were built up... περισσότερα »
Delivery of chitosan/dsRNA nanoparticles for silencing of wing development vestigial (vg) gene in Aedes aegypti mosquitoes
Publication date: May 2016 *Source:*International Journal of Biological Macromolecules, Volume 86 Author(s): D. Ramesh Kumar, P. Saravana Kumar, M. Rajiv Gandhi, Naif Abdullah Al-Dhabi, M. Gabriel Paulraj, S. Ignacimuthu RNA interference (RNAi) has been used as a gene silencing strategy by the introduction of long double stranded RNA (dsRNA) for the control of pest insects. The aim of the present study was to examine whether the expression of vg gene which is responsible for wing development, can be repressed by chitosan/dsRNA based nanoparticles in Aedes aegypti. The vestigial gene ...περισσότερα »
A chronic care ostomy self-management program for cancer survivors
Abstract Background Individuals with ostomies experience extensive changes in health-related quality of life (HRQOL) and daily routine. Patients and families are typically forced to use trial and error to improve self-management. Methods This is a longitudinal one-group design pilot study of a five-session ostomy self-care curriculum based on the Chronic Care Model to improve HRQOL and self-management for cancer survivors with ostomies. Participants were surveyed to evaluate each session. Multiple instruments were administered to examine outcomes at baseline, post-intervention, and ... περισσότερα »
Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized 13C studies
Purpose To enable large field-of-view, time-resolved volumetric coverage in hyperpolarized 13C metabolic imaging by implementing a novel data acquisition and image reconstruction method based on the compressed sensing framework. Methods A spectral-spatial pulse for single-resonance excitation followed by a symmetric echo-planar imaging (EPI) readout was implemented for encoding a 72 × 18 cm2 field of view at 5 × 5 mm2 resolution. Random undersampling was achieved with blipped z-gradients during the ramp portion of the echo-planar imaging readout. The sequence and reconstruction wer...περισσότερα »
Vanderbilt Audiology’s Journal Club: Noise Reduction, Directional Microphones, and Listening Effort
Dr. Gus Mueller: Our presenter today for our Vanderbilt Journal Club is Dr. Erin Picou. We are fortunate to have someone talking about current hearing aid research who also is conducting and publishing her own research in this area. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PuwWxe via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qut6my via IFTTT from #Med Blogs by Alex... περισσότερα »
Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I–III esophageal cancer
Abstract The effect of proton beam therapy (PBT) on various cancers is controversial. We aimed to evaluate the efficacy and safety of PBT with alternating chemoradiotherapy (ACRT) for patients with stage I–III esophageal cancer. Two cycles of systemic chemotherapy with a continuous infusion of 5-fluorouracil (5-FU) on days 1–5 and a 5h infusion of nedaplatin (NDP) on day 6 were accompanied by thoracic irradiation using X-ray therapy and PBT. During the first half of the treatment, X-rays were delivered to the prophylactic area. During the second half of the treatment, proton beams ... περισσότερα »
Phonak CROS II
Editor’s Note: This text course is an edited transcript of a live webinar. Download supplemental course materials.Learning ObjectivesAt the conclusion of this course, you will be able to describe the different wireless CROS and Bi-CROS solution [image: 1PuwWx6] from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1PuwYoE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NucvbW via I...περισσότερα »
Characterization of the Escherichia coli YajL, YhbO and ElbB glyoxalases
The DJ-1 superfamily is a group of proteins that shares a similarity with the human DJ-1, known to be associated with Parkinson disease. Novel glyoxalase activity, converting α-oxoaldehydes to carboxylic acids, has been reported for DJ-1 homologs in humans, worms, plants and bacteria. The four *Escherichia coli* genes, *hchA*, *yajL*, *yhbO* and *elbB*, have been known to share sequence similarities and catalytic residues with other DJ-1 superfamily members. We investigated here whether they exhibit similar glyoxalase activity, as previously shown for HchA protein. Purified YajL, ...περισσότερα »
Everybody on your Feet! Introducing Cheer!
This course is an introduction to the Cheer family of products. Cheer is a well-balanced line-up of Sonic products featuring impressive sound quality statistics. Anyone who has ever fit a Sonic product knows the natural component of sound is something that we hold near and dear to our hearts. Today, we are going to talk about all of the things that are important to Cheer. First and foremost is the sound. Natural sound begins with a sound processor that is engineered for premium quality. We have an industry-acclaimed system. [image: 1OIQLx5] from #ORL-AlexandrosSfakianakis via ola ... περισσότερα »
Cancer patients' referral wish: effects of distress, problems, socio-demographic and illness-related variables and social support sufficiency
Abstract Background The present study's aim was to examine effects of cancer patients' perceived distress and problems, socio-demographic and illness-related variables and social support sufficiency on referral wish. Methods A cross-sectional group of 1340 patients (response = 51%) completed a questionnaire consisting of the Dutch version of the Distress Thermometer and Problem List, including the referral wish question, and questions on socio-demographic and illness-related variables and perceived social support sufficiency. Univariate and multivariate analyses were performed to i... περισσότερα »
Associations of Inter- and Intraday Temperature Change With Mortality
In this study we evaluated the association between temperature variation and mortality and compared it with the contribution due to mean daily temperature in 6 cities with different climates. Quasi-Poisson time series regression models were applied to estimate the associations (relative risk and 95% confidence interval) of mean daily temperature (99th and 1st percentiles, with temperature of minimum mortality as the reference category), interday temperature variation (difference between the mean temperatures of 2 neighboring days) and intraday temperature variation (diurnal temper... περισσότερα »
Accelerated 3D echo-planar imaging with compressed sensing for time-resolved hyperpolarized 13C studies
Purpose To enable large field-of-view, time-resolved volumetric coverage in hyperpolarized 13C metabolic imaging by implementing a novel data acquisition and image reconstruction method based on the compressed sensing framework. Methods A spectral-spatial pulse for single-resonance excitation followed by a symmetric echo-planar imaging (EPI) readout was implemented for encoding a 72 × 18 cm2 field of view at 5 × 5 mm2 resolution. Random undersampling was achieved with blipped z-gradients during the ramp portion of the echo-planar imaging readout. The sequence and reconstruction wer...περισσότερα »
A chronic care ostomy self-management program for cancer survivors
AbstractBackground Individuals with ostomies experience extensive changes in health-related quality of life (HRQOL) and daily routine. Patients and families are typically forced to use trial and error to improve self-management. Methods This is a longitudinal one-group design pilot study of a five-session ostomy self-care curriculum based on the Chronic Care Model to improve HRQOL and self-management for cancer survivors with ostomies. Participants were surveyed to evaluate each session. Multiple instruments were administered to examine outcomes at baseline, post-intervention, and a... περισσότερα »
Cancer patients’ referral wish: effects of distress, problems, socio-demographic and illness-related variables and social support sufficiency
AbstractBackground The present study’s aim was to examine effects of cancer patients’ perceived distress and problems, socio-demographic and illness-related variables and social support sufficiency on referral wish. Methods A cross-sectional group of 1340 patients (response = 51%) completed a questionnaire consisting of the Dutch version of the Distress Thermometer and Problem List, including the referral wish question, and questions on socio-demographic and illness-related variables and perceived social support sufficiency. Univariate and multivariate analyses were performed to in... περισσότερα »
Propensity score matched comparison of SBRT versus IMRT for the treatment of localized prostate cancer
AbstractObjective Stereotactic body radiation therapy (SBRT) is an attractive option for prostate cancer due to its short treatment duration and cost. In this report, we compare the efficacy and toxicity outcomes of prostate cancer patients treated with SBRT to those who received intensity-modulated radiation therapy (IMRT). Methods Two hundred sixty-three patients with localized prostate adenocarcinoma were included, ranging from clinically very low- to high-risk groups. We retrospectively compare consecutive patients treated with SBRT with consecutive patients treated with conven...περισσότερα »
Curing Cancer Once and For All – Laurel Leader Call
[image: 1nhwlC5] Jewocity.com (press release) (blog)*Curing Cancer Once and For All* *Laurel Leader Call* However, ominously, some *cancers* still are on the rise, including certain types of leukemia and *cancers* of the tongue, *tonsil*, small intestine, liver, pancreas, kidney and thyroid. On the Labor-HHS Subcommittee, Fattah has worked with his colleagues on *…* Obama kicks off new initiative to cure *cancer*Jewocity.com (press release) (blog) *all 158 news articles »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZY3ggE via IFTTT from #Med Blog...περισσότερα »
GSE77157 The target spectrum of SdsR small RNA in Salmonella
*Contributors* : Kathrin Fröhlich ; Katharina Haneke ; Kai Papenfort ; Jörg Vogel *Series Type* : Expression profiling by array *Organism* : Salmonella enterica ; Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 Enteric model bacteria such as Escherichia coli and Salmonella enterica express hundreds of small non-coding RNAs (sRNAs), targets for most of which are yet unknown. Some of these sRNAs are remarkably well-conserved, indicating that that they serve cellular functions that go beyond the necessities of a single organism. One of these “core sRNA” of largely ...περισσότερα »
Use of the new da Vinci Xi® during robotic rectal resection for cancer: a pilot matched-case comparison with the da Vinci Si®
Abstract Background The aim of this study was to compare the short-term outcomes of robotic rectal resection with total mesorectal excision (TME) for rectal cancer, with the use of the new da Vinci Xi® (Xi-RobTME group) and the da Vinci Si® (Si-RobTME group). Methods Ten patients with histologically confirmed rectal cancer underwent robot-assisted TME with the use of the new da Vinci Xi. The outcomes of Xi-RobTME group were compared with a Si-RobTME group selected using a case-matched methodology. Results Overall operative times and mean hospital stays were shorter in the Xi-R...περισσότερα »
A modular force-controlled robotic instrument for minimally invasive surgery – efficacy for being used in autonomous grasping against a variable pull force
Abstract Background Many deficiencies of minimally invasive robotic surgery systems can be eliminated by using automated laparoscopic tools with force measurement and control capability. Method A fully modular, automated laparoscopic instrument with a proximal force sensory system was designed and fabricated. The efficacy of the instrument was evaluated experimentally when functioning in an autonomous force-controlled grasping scheme. Results The designed instrument was shown to work easily with standard laparoscopic tools, with the whole distal part detachable for autoclave st... περισσότερα »
Do measurements of inflammatory mediators in blood predict recurrence in patients with bisphosphonate-related osteonecrosis of the jaws?
Do measurements of inflammatory mediators in blood predict recurrence in patients with bisphosphonate-related osteonecrosis of the jaws?: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is well-recognised, difficult to manage, and often recurs. The aim of this study was to examine the value of preoperative measurements of inflammatory mediators in blood in 212 patients with BRONJ who were studied prospectively. Multiple logistic regression analysis was used to assess the importance of the amounts of substances in the blood that are independently associated with the dependen... περισσότερα »
Gorham disease is a rare disease of the bony skeleton that is characterised by osteolysis
Rare incidence of Gorham disease with limited involvement of the maxilla: case report: Gorham disease is a rare disease of the bony skeleton that is characterised by osteolysis. The cause is unknown. The axial skeleton and mandible are the most commonly affected, and in rare incidences, the maxilla. We know of only three cases in the maxilla alone. Limited knowledge about the origins and pathophysiology of the disease make diagnosis challenging. To increase awareness, we describe a rare case, which was limited to the maxilla.
Outfracture of the inferior turbinates during superior repositioning Le Fort I osteotomy with cone-beam computed tomographic analysis of the volume of the nasal cavity
Outfracture of the inferior turbinates during superior repositioning Le Fort I osteotomy with cone-beam computed tomographic analysis of the volume of the nasal cavity Abstract We have investigated the volumes of the nasal cavities of 35 patients treated with superior repositioning Le Fort I osteotomy by analysing cone-beam computed tomography (CT) data with a 3-dimensional reconstruction program to correlate changes in the volume of the nasal cavity that were associated with the maxillary superior repositioning and the role of outfracture of the inferior turbinates. The patients... περισσότερα »
Complications following facial reconstruction procedures
Prevalence and predictors of complications following facial reconstruction procedures via Oral and Maxillofacial Surgery Publication date: Available online 24 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): S. Prakasam, K. Stein, M.K. Lee, S. Rampa, R. Nalliah, V. Allareddy, V. Allareddy Facial reconstruction procedures are immensely challenging and are done for a multitude of reasons. The purpose of this report is to provide nationally representative estimates of different types of facial reconstructive procedures and to examine prevalence and... περισσότερα »
The endoscopic management of foreign bodies in the upper gastrointestinal tract
Chinese expert consensus on the endoscopic management of foreign bodies in the upper gastrointestinal tract (2015, Shanghai, China): The ingestion of foreign bodies is a common emergency in clinical practice, representing about 4% of all emergency endoscopies. If not treated promptly, ingested foreign bodies may cause serious complications, even result in death. Currently, the international guidelines and consensuses on the management of foreign bodies in the upper gastrointestinal tract mainly include Management of ingested foreign bodies and food impactions by the American Societ...περισσότερα »
Silicone Maxillofacial Elastomers
Mechanical Properties and Simulated Aging of Silicone Maxillofacial Elastomers: Advancements in the Past 45 Years: Abstract Purpose To identify and discuss the findings of publications on mechanical behavior of maxillofacial prosthetic materials published since 1969. Methods Original experimental articles reporting on mechanical properties of maxillofacial prosthetic materials were included. A two-stage search of the literature, electronic and hand search, identified relevant published studies up to May 2015. An extensive electronic search was conducted of databases including PubMed...περισσότερα »
Gait & Posture
Biomechanical and perceived differences between overground and treadmill walking in children with cerebral palsy Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Taeyou Jung, Yumi Kim, Luke E. Kelly, Mark F. Abel The treadmill is widely used as an instrument for gait training and analysis. The primary purpose of this study was to compare biomechanical variables between overground and treadmill walking in children with cerebral palsy (CP). Perceived differences between the two walking modes were also investigated by comparing self-selected walking speeds....περισσότερα »
Administrative Sciences, Vol. 6, Pages 2: Acknowledgement to Reviewers of Administrative Sciences in 2015
The editors of Administrative Sciences would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1lJCru0 via IFTTT
Sensors, Vol. 16, Pages 149: Improved Circuits with Capacitive Feedback for Readout Resistive Sensor Arrays
One of the most suitable ways of distributing a resistive sensor array for reading is an array with M rows and N columns. This allows reduced wiring and a certain degree of parallelism in the implementation, although it also introduces crosstalk effects. Several types of circuits can carry out the analogue-digital conversion of this type of sensors. This article focuses on the use of operational amplifiers with capacitive feedback and FPGAs for this task. Specifically, modifications of a previously reported circuit are proposed to reduce the errors due to the non-idealities of the ... περισσότερα »
Sensors, Vol. 16, Pages 151: Evaluation of the Bitterness of Traditional Chinese Medicines using an E-Tongue Coupled with a Robust Partial Least Squares Regression Method
To accurately, safely, and efficiently evaluate the bitterness of Traditional Chinese Medicines (TCMs), a robust predictor was developed using robust partial least squares (RPLS) regression method based on data obtained from an electronic tongue (e-tongue) system. The data quality was verified by the Grubb's test. Moreover, potential outliers were detected based on both the standardized residual and score distance calculated for each sample. The performance of RPLS on the dataset before and after outlier detection was compared to other state-of-the-art methods including multivaria... περισσότερα »
Behavioral Sciences, Vol. 6, Pages 6: Acknowledgement to Reviewers of Behavioral Sciences in 2015
The editors of Behavioral Sciences would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1UlDVXa via IFTTT
Materials, Vol. 9, Pages 70: Building Energy Storage Panel Based on Paraffin/Expanded Perlite: Preparation and Thermal Performance Study
This study is focused on the preparation and performance of a building energy storage panel (BESP). The BESP was fabricated through a mold pressing method based on phase change material particle (PCMP), which was prepared in two steps: vacuum absorption and surface film coating. Firstly, phase change material (PCM) was incorporated into expanded perlite (EP) through a vacuum absorption method to obtain composite PCM; secondly, the composite PCM was immersed into the mixture of colloidal silica and organic acrylate, and then it was taken out and dried naturally. A series of experim...περισσότερα »
Remote Sensing, Vol. 8, Pages 82: A Linear Feature-Based Approach for the Registration of Unmanned Aerial Vehicle Remotely-Sensed Images and Airborne LiDAR Data
Compared with traditional manned airborne photogrammetry, unmanned aerial vehicle remote sensing (UAVRS) has the advantages of lower cost and higher flexibility in data acquisition. It has, therefore, found various applications in fields such as three-dimensional (3D) mapping, emergency management, and so on. However, due to the instability of the UAVRS platforms and the low accuracy of the onboard exterior orientation (EO) observations, the use of direct georeferencing image data leads to large location errors. Light detection and ranging (LiDAR) data, which is highly accurate 3D... περισσότερα »
Challenges, Vol. 7, Pages 1: Acknowledgement to Reviewers of Challenges in 2015
The editors of Challenges would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1ORkMJ5 via IFTTT
Axioms, Vol. 5, Pages 3: Acknowledgement to Reviewers of Axioms in 2015
The editors of Axioms would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1ORkMsF via IFTTT
Molbank, Vol. 2016, Article M887: Acknowledgement to Reviewers of Molbank in 2015
The editors of Molbank would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1ntwWS3 via IFTTT
Microarrays, Vol. 5, Pages 4: Acknowledgement to Reviewers of Microarrays in 2015
The editors of Microarrays would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1ORkMst via IFTTT
Micromachines, Vol. 7, Pages 18: Devices Based on Co-Integrated MEMS Actuators and Optical Waveguide: A Review
The convergence of Micro Electro Mechanical Systems (MEMS) and optics was, at the end of the last century, a fertile ground for a new breed of technological and scientific achievements. The weightlessness of light has been identified very early as a key advantage for micro-actuator application, giving rise to optical free-space MEMS devices. In parallel to these developments, the past 20 years saw the emergence of a less pursued approach relying on guided optical wave, where, pushed by the similarities in fabrication process, researchers explored the possibilities offered by mergi... περισσότερα »
Processes, Vol. 4, Pages 4: State Observer Design for Monitoring the Degree of Polymerization in a Series of Melt Polycondensation Reactors
A nonlinear reduced-order state observer is applied to estimate the degree of polymerization in a series of polycondensation reactors. The finishing stage of polyethylene terephthalate synthesis is considered in this work. This process has a special structure of lower block triangular form, which is properly utilized to facilitate the calculation of the state-dependent gain in the observer design. There are two possible on-line measurements in each reactor. One is continuous, and the other is slow-sampled with dead time. For the slow-sampled titration measurement, inter-sample beha... περισσότερα »
Molecules, Vol. 21, Pages 135: Coumarins as Potential Antioxidant Agents Complemented with Suggested Mechanisms and Approved by Molecular Modeling Studies
Syntheses of coumarins, which are a structurally interesting antioxidant activity, was done in this article. The modification of 7-hydroxycoumarin by different reaction steps was done to yield target compounds. Molecular structures were characterized by different spectroscopical techniques (Fourier transformation infrared and nuclear magnetic resonance). Antioxidant activities were performed by using various in vitro spectrophometric assays against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydrogen peroxide (H2O2). All compounds exhibited high efficiency as antioxidants com... περισσότερα »
Regulation of the T-type Ca2+ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H2S in nociception
Abstract Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide. Indeed, many of the biological actions of these gases can be accounted for by their ability to modulate ion channel activity. Here, we report recent evidence that H2S is a modulator of low voltage-activated T-type Ca2+ channels, and discriminates between the different subtypes of T-type Ca2+ channel in that it selectively modulates Cav3.2, whilst Cav3.1 and Cav3.3 are unaffected. At hig... περισσότερα »
IJERPH, Vol. 13, Pages 156: Smoke-Free Public Policies and Voluntary Policies in Personal Settings in Tbilisi, Georgia: A Qualitative Study
Georgia has limited tobacco control policies, particularly in the area of smoke-free public policies, which may influence the adoption of smoke-free home rules. We qualitatively examined knowledge about and reactions to public and personal smoke-free policies among Tbilisi residents. In Spring 2014, we conducted six focus groups among 47 total participants—two among male smokers, one among male nonsmokers, two among female smokers, and one among female nonsmokers. Our sample was 48.9% male and 70.2% past 30-day smokers. Most believed that SHS was dangerous, with particular concern ... περισσότερα »
Aerospace, Vol. 3, Pages 4: The Effect of the Phase Angle between the Forewing and Hindwing on the Aerodynamic Performance of a Dragonfly-Type Ornithopter
Dragonflies achieve agile maneuverability by flapping four wings independently. Different phase angles between the flapping forewing and hindwing have been observed during various flight modes. The aerodynamic performance depends on phase angle control, as exemplified by an artificial flying ornithopter. Here, we present a dragonfly-like ornithopter whose phase angle was designed to vary according to the phase lag between the slider-cranks of the forewing and hindwing. Two microelectromechanical systems (MEMS) differential pressure sensors were attached to the center of both forew...περισσότερα »
Micromachines, Vol. 7, Pages 17: Numerical Investigation of Cell Encapsulation for Multiplexing Diagnostic Assays Using Novel Centrifugal Microfluidic Emulsification and Separation Platform
In the present paper, we report a novel centrifugal microfluidic platform for emulsification and separation. Our design enables encapsulation and incubation of multiple types of cells by droplets, which can be generated at controlled high rotation speed modifying the transition between dripping-to-jetting regimes. The droplets can be separated from continuous phase using facile bifurcated junction design. A three dimensional (3D) model was established to investigate the formation and sedimentation of droplets using the centrifugal microfluidic platform by computational fluid dynam... περισσότερα »
JCDD, Vol. 3, Pages 3: Long-term Benefits of Risk Factor Reduction in Takotsubo Cardiomyopathy.—A Comment on Khalighi et al. Entitled “Takotsubo Cardiomyopathy: A Long Term Follow-up Shows Benefit with Risk Factor Reduction”, J. Cardiovasc. Dev. Dis., 2015, 2, 273–281.
Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is also popularly referred to as "broken heart syndrome" or "apical ballooning syndrome". [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1S5ceom via IFTTT
Gels, Vol. 2, Pages 6: Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications
Poly(vinyl caprolactam) (PNVCL) is one of the most important thermoresponsive polymers because it is similar to poly(N-isopropyl acrylamide). PNVCL precipitates from aqueous solutions in a physiological temperature range (32–34 °C). The use of PNVCL instead of PNIPAM is considered advantageous because of the assumed lower toxicity of PNVCL. PNVCL copolymer gels are sensitive to external stimuli, such as temperature and pH; which gives them a wide range of biomedical applications and consequently attracts considerable scientific interest. This review focuses on the recent studies o...περισσότερα »
Dynamic Postural Stability
The effect of weight-bearing asymmetry on dynamic postural stability in healthy young individuals via Gait & Posture Publication date: March 2016 *Source:*Gait & Posture, Volume 45 Author(s): Digna de Kam, Jip. F. Kamphuis, Vivian Weerdesteyn, Alexander C.H. Geurts BackgroundIn people with lateralized disorders, such as stroke, Weight-Bearing Asymmetry (WBA) is common. It is associated with postural instability, however, WBA is one of several abnormalities that may affect postural stability in these disorders. Therefore, we investigated the isolated effects of WBA on dynamic postural ... περισσότερα »
Audiology
Everybody on your Feet! Introducing Cheer! This course is an introduction to the Cheer family of products. Cheer is a well-balanced line-up of Sonic products featuring impressive sound quality statistics. Anyone who has ever fit a Sonic product knows the natural component of sound is something that we hold near and dear to our hearts. Today, we are going to talk about all of the things that are important to Cheer. First and foremost is the sound. Natural sound begins with a sound processor that is engineered for premium quality. We have an industry-acclaimed system. Phonak CROS II E... περισσότερα »
Congenital nasal pyriform aperture stenosis
: Elaboration of a management algorithm from 25 years of experience via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): E. Moreddu, C. L.E. Treut-Gay, J.M. Triglia, R. Nicollas IntroductionCongenital nasal pyriform aperture stenosis (CNPAS) is a rare disease presenting with neonatal respiratory distress, often associated with other anomalies.Materials and methodsThis study reports the clinical and radiological characteristics of the patients managed in The ... περισσότερα »
Management and prevention of acute bleedings in the head and neck area with interventional radiology
Management and prevention of acute bleedings in the head and neck area with interventional radiology: Abstract BackgroundThe Interventional Neuroradiology is becoming more important in the interdisciplinary treatment of acute haemorrhages due to vascular erosion and vascular tumors in the head and neck area. The authors report on acute extracranial haemorrhage in emergency situations but also on preventive embolization of good vascularized tumors preoperatively and their outcome. MethodsRetrospective analysis of 52 patients, who underwent an interdisciplinary approach of the O... περισσότερα »
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: A novel predictor or fad? via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Mehmet Akif Abakay, Timur Ekiz, Ahmet Cemal Pazarlı Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: which method has more benefit on clinic? via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 25 January 201... περισσότερα »
Language skills and phonological awareness in children with cochlear implants
Language skills and phonological awareness in children with cochlear implants and normal hearing via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 25 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Zahra Soleymani, Najmeh Mahmoodabadi, Mina Mohammadi Nouri ObjectivesEarly auditory experience plays a major role in language acquisition. Linguistic and metalinguistic abilities of children aged 5 to 5.5 years with cochlear implants (CIs) were compared to age-matched children with normal hearing (NH) to inves...περισσότερα »
Analysis of colorectal cancer outcomes for the Australian National Bowel Cancer Screening Program
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Abstract The Australian National Bowel Cancer Screening Program (NBCSP) was introduced in Australia in 2006 with the aim of reducing morbidity and mortality from colorectal cancer. This study looked to evaluate the effectiveness of the NBCSP against this aim. The study linked 2006–2008 NBCSP invitees to colorectal cancer incidence and mortality data and categorized NBCSP […]
Analysis of colorectal cancer outcomes for the Australian National Bowel Cancer Screening Program
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Abstract The Australian National Bowel Cancer Screening Program (NBCSP) was introduced in Australia in 2006 with the aim of reducing morbidity and mortality from colorectal cancer. This study looked to evaluate the effectiveness of the NBCSP against this aim. The study linked 2006–2008 NBCSP invitees to colorectal cancer incidence and mortality data and categorized NBCSP […]
Sheet-like microfossils from hydrothermally influenced basinal cherts of the lower Cambrian (Terreneuvian) Niutitang Formation, Guizhou, South China
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Publication date: Available online 25 January 2016 Source:Palaeoworld Author(s): Lei-Ming Yin, Tenger Borjigin, Andrew H. Knoll, Li-Zeng Bian, Xiao-Min Xie, Fang Bao, Zhi-Ji Ou Early diagenetic cherts in basinal shales of the lower Cambrian (Terreneuvian) Niutitang Formation, exposed in the Yangtiao section, Majiang, Guizhou Province, South China, contain abundant sheet-like microfossils. The sheets are carbonaceous, […]
Prevention and Management of Procedural Pain in the Neonate: An Update
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
The prevention of pain in neonates should be the goal of all pediatricians and health care professionals who work with neonates, not only because it is ethical but also because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest […]
AAP Publications Reaffirmed or Retired
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JwYPlV via IFTTT
Chronic Fatigue Syndrome at Age 16 Years
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
BACKGROUND: In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity. METHODS: ALSPAC data were used to estimate the prevalence of chronic fatigue syndrome (CFS) at age 16 […]
GSE73210 Identification of factors involved in target RNA-directed microRNA degradation
Contributors : Gabrielle Haas ; Semih Cetin ; Mélanie Messmer ; Béatrice Chane-Woon-Ming ; Olivier Terenzi ; Johana Chicher ; Lauriane Kuhn ; Philippe Hammann ; Sébastien Pfeffer Series Type : Non-coding RNA profiling by high throughput sequencing Organism : Homo sapiens The mechanism by which micro (mi)RNAs control their target gene expression is now… Continue reading GSE73210 Identification of factors involved in target RNA-directed microRNA degradation
Apo-lipoproteins, lipids and risk of cancer
Abstract The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and Cancer Study,… Continue reading Apo-lipoproteins, lipids and risk of cancer
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
Summary Echinocandin resistance in Candida glabrata is emerging and is associated with the presence of FKS mutations. In this study, we analysed the antifungal susceptibility, presence of FKS mutations and clonality of C. glabrata blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 C. glabrata bloodstream isolates from two university… Continue reading Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In… Continue reading Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
Language skills and phonological awareness in children with cochlear implants and normal hearing
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Zahra Soleymani, Najmeh Mahmoodabadi, Mina Mohammadi Nouri ObjectivesEarly auditory experience plays a major role in language acquisition. Linguistic and metalinguistic abilities of children aged 5 to 5.5 years with cochlear implants (CIs) were compared to age-matched children with normal hearing (NH) to… Continue reading Language skills and phonological awareness in children with cochlear implants and normal hearing
Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In… Continue reading Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
JCDD, Vol. 3, Pages 3: Long-term Benefits of Risk Factor Reduction in Takotsubo Cardiomyopathy.—A Comment on Khalighi et al. Entitled “Takotsubo Cardiomyopathy: A Long Term Follow-up Shows Benefit with Risk Factor Reduction”, J. Cardiovasc. Dev. Dis., 2015, 2, 273–281.
Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is also popularly referred to as “broken heart syndrome” or “apical ballooning syndrome”. […] from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1S5ceom via IFTTT
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (n = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, in vitro susceptibility and… Continue reading Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson’s disease
ABSTRACT Introduction Higher serum urate predicts slower progression in PD. The aim of this work was to assess whether oral inosine alters antioxidant capacity of plasma or CSF or urinary markers of oxidative injury in early PD. Methods We assayed plasma and CSF antioxidant capacity by ferric-reducing antioxidant power and measured DNA oxidation adduct 8-hydroxydeoxyguanosine… Continue reading Oral Inosine Persistently Elevates Plasma antioxidant capacity in Parkinson’s disease
Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak classification of complex renal cysts
Aim To compare contrast-enhanced ultrasound and contrast-enhanced computed tomography in the evaluation of complex renal cysts using the Bosniak classification. Methods Forty-six patients with 51 complex renal cysts were prospectively examined using contrast-enhanced ultrasound and contrast-enhanced computed tomography and images analysed by two observers using the Bosniak classification. Adverse effects and patients’ preference were assessed… Continue reading Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak class... περισσότερα »
Apo-lipoproteins, lipids and risk of cancer
Abstract The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and Cancer Study, a population-based prospective cohort study, enrolled 17,035 women and 11,063 men (1991-1996). Incident cancer cases were ascertained by record linkage with the Swed...περισσότερα »
Early Candidate Biomarkers of Non-Small Cell Lung Cancer Are Screened and Identified in Premalignant Lung Lesions
A specific protein profile that accompanies neoplastic transformation in the premalignant airway epithelium could provide an opportunity for early diagnosis of lung cancer. The aim of this study was to screen and identify early candidate biomarkers of non–small cell lung cancer. Thirteen non–small cell lung cancer samples were obtained within 30 minutes after a surgical resection. Laser capture microdissection was performed to enrich the normal lung cell and squamous metaplasia or atypical adenomatous hyperplasia cell populations. The resulting tandem mass spectrum was automatical... περισσότερα »
A time and motion study of subcutaneous versus intravenous trastuzumab in patients with HER2-positive early breast cancer
Abstract Within PrefHer (NCT01401166), patients and healthcare professionals (HCPs) preferred subcutaneous (SC) over intravenous (IV) trastuzumab. We undertook a prospective, observational time and motion study to quantify patients' time in infusion chairs and active HCP time in PrefHer. Patients with HER2-positive early breast cancer received four adjuvant cycles of SC trastuzumab (600 mg fixed dose via SC single-use injection device [SID, Cohort 1] or SC handheld syringe [HHS, Cohort 2]) then four cycles of standard IV trastuzumab or the reverse sequence. Generic case report form...περισσότερα »
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
Summary Echinocandin resistance in *Candida glabrata* is emerging and is associated with the presence of *FKS* mutations. In this study, we analysed the antifungal susceptibility, presence of *FKS* mutations and clonality of *C. glabrata* blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 *C. glabrata* bloodstream isolates from two university hospitals was performed with broth microdilution method according to EUCAST. In addition, all isolates were screened for *FKS* mutations. Molecular fingerprinting was performed by microsatellite PCR ...περισσότερα »
Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR
Summary Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this pathology, to support a quick and accurate distinction between onychomycosis and other nail damage. Commercial kits are now available from several companies for improving trad... περισσότερα »
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
[image: cover.gif?v=1&s=09d3f8c75474f06ee5ac3319] Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (*n* = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, *in vitro* susceptibility and 12 weeks survival were analysed. Global incidence of candidemia was 0.37‰ admissions. Higher incidences were observed in haematology (6.65‰) and intensi... περισσότερα »
Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients
Summary Background Sorbitan sesquioleate (SSO) has been added to fragrance mix I (FM I) as an emulsifier since the 1990s. Being a contact allergen itself, SSO has the potential to cause false-positive reactions to FM I. Recent results obtained with selected FM I-positive patients have shown that 5% have concomitant positive reactions to SSO. Objectives To investigate the 5-year prevalence of contact allergy to SSO and evaluate the importance of SSO allergy when patch test results for FM I are interpreted. Methods This was a retrospective database study of consecutively patch te... περισσότερα »
Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series
Summary Background Essential oils are fragrance substances that are labelled on cosmetic products by their INCI names, potentially confusing consumers. Objectives To establish whether contact allergy to essential oils might be missed if not specifically tested for. Methods We tested 471 patients with 14 essential oils and 2104 patients with *Melaleuca alternifolia* oil between January 2008 and June 2014. All patients were tested with fragrance mix I, fragrance mix II, hydroxyisohexyl 3-cyclohexene carboxaldehyde, and *Myroxylon pereirae*. Three hundred and twenty-six patients w... περισσότερα »
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
Summary Echinocandin resistance in *Candida glabrata* is emerging and is associated with the presence of *FKS* mutations. In this study, we analysed the antifungal susceptibility, presence of *FKS* mutations and clonality of *C. glabrata* blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 *C. glabrata* bloodstream isolates from two university hospitals was performed with broth microdilution method according to EUCAST. In addition, all isolates were screened for *FKS* mutations. Molecular fingerprinting was performed by microsatellite PCR ...περισσότερα »
Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR
Summary Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this pathology, to support a quick and accurate distinction between onychomycosis and other nail damage. Commercial kits are now available from several companies for improving trad... περισσότερα »
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
[image: cover.gif?v=1&s=09d3f8c75474f06ee5ac3319] Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (*n* = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, *in vitro* susceptibility and 12 weeks survival were analysed. Global incidence of candidemia was 0.37‰ admissions. Higher incidences were observed in haematology (6.65‰) and intensi... περισσότερα »
Membranes, Vol. 6, Pages 2: Acknowledgement to Reviewers of Membranes in 2015
The editors of Membranes would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2015. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1QLmZeq via IFTTT
Fermentation, Vol. 2, Pages 3: Characterizing the Phenotypic Responses of Escherichia coli to Multiple 4-Carbon Alcohols with Raman Spectroscopy
The phenotypic responses of E. coli cells exposed to 1.2% (v/v) of 1-butanol, 2-butanol, isobutanol, tert-butanol, and 1,4-butanediol were studied in near real-time using Raman spectroscopy. A method of "chemometric fingerprinting" was employed that uses multivariate statistics (principal component analysis and linear discriminant analysis) to identify E. coli phenotypic changes over a 180 min post-treatment time-course. A toxicity study showed extreme variability among the reduction in culture growth, with 1-butanol showing the greatest toxicity and 1,4-butanediol showing relativ... περισσότερα »
Materials, Vol. 9, Pages 68: Mechanical Strength Improvements of Carbon Nanotube Threads through Epoxy Cross-Linking
Individual Carbon Nanotubes (CNTs) have a great mechanical strength that needs to be transferred into macroscopic fiber assemblies. One approach to improve the mechanical strength of the CNT assemblies is by creating covalent bonding among their individual CNT building blocks. Chemical cross-linking of multiwall CNTs (MWCNTs) within the fiber has significantly improved the strength of MWCNT thread. Results reported in this work show that the cross-linked thread had a tensile strength six times greater than the strength of its control counterpart, a pristine MWCNT thread (1192 MPa ...περισσότερα »
Marine Drugs, Vol. 14, Pages 20: Larvicidal Potential of the Halogenated Sesquiterpene (+)-Obtusol, Isolated from the Alga Laurencia dendroidea J. Agardh (Ceramiales: Rhodomelaceae), against the Dengue Vector Mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae)
Dengue is considered a serious public health problem in many tropical regions of the world including Brazil. At the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, Aedes aegypti Linnaeus. In the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. In our work, we investigated the toxicity of a bioactive compound extracted from the red alga Laurencia dendroidea J. Agardh. The initial results demonstrated that crude extracts, at a c... περισσότερα »
Comparing the short-term outcomes of laparoscopic distal gastrectomy with D1+ and D2 lymph node dissection for gastric cancer
Abstract Introduction Laparoscopic distal gastrectomy (LDG) with D1+ lymph node dissection (LND) for early gastric cancer has been widely accepted. However, LDG with D2 LND for advanced gastric cancer remains in limited use. The aim of this retrospective study was to clarify the safety of LDG with D2 LND for gastric cancer. Methods From January 2010 to September 2014, 296 patients underwent LDG; those who received D1+ LND (*n* = 230) or D2 LND (*n* = 66) were included in this study. The clinicopathological characteristics and short-term outcomes of both groups were investigated ...περισσότερα »
Clockwise insertion: a risk factor of pancreatic hyperamylasemia and acute pancreatitis after peroral balloon-assisted enteroscopy
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1NunCla via IFTTT
23andMe markets carrier screening service directly to consumers
from Genes via ola Kala on Inoreader http://ift.tt/1WJjNQn via IFTTT
American Journal of Medical Genetics Part A: Volume 170A, Number 2, Feburary 2016
from Genes via ola Kala on Inoreader http://ift.tt/1Jx1dJh via IFTTT
Publication schedule for 2016
from Genes via ola Kala on Inoreader http://ift.tt/1Ulz4oR via IFTTT
Sheet-like microfossils from hydrothermally influenced basinal cherts of the lower Cambrian (Terreneuvian) Niutitang Formation, Guizhou, South China
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 25 January 2016 Source:Palaeoworld Author(s): Lei-Ming Yin, Tenger Borjigin, Andrew H. Knoll, Li-Zeng Bian, Xiao-Min Xie, Fang Bao, Zhi-Ji Ou Early diagenetic cherts in basinal shales of the lower Cambrian (Terreneuvian) Niutitang Formation, exposed in the Yangtiao section, Majiang, Guizhou Province, South China, contain abundant sheet-like microfossils. The sheets are carbonaceous, […]
Prevention and Management of Procedural Pain in the Neonate: An Update
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The prevention of pain in neonates should be the goal of all pediatricians and health care professionals who work with neonates, not only because it is ethical but also because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest […]
AAP Publications Reaffirmed or Retired
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JwYPlV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Chronic Fatigue Syndrome at Age 16 Years
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND: In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity. METHODS: ALSPAC data were used to estimate the prevalence of chronic fatigue syndrome (CFS) at age 16 […]
Chronische Urtikaria: Viele behandeln sich lieber selbst
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ATTENTUS-Survey Eine Umfrage unter Patienten mit chronischer Urtikaria zeichnet ein düsteres Bild der Versorgunglage in Deutschland. Viele, darunter drei von vier Langzeitpatienten, haben es aufgegeben, auf ärztliche Hilfe zu hoffen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1K69vYF via IFTTT
Chronische Urtikaria: Viele behandeln sich lieber selbst
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ATTENTUS-Survey Eine Umfrage unter Patienten mit chronischer Urtikaria zeichnet ein düsteres Bild der Versorgunglage in Deutschland. Viele, darunter drei von vier Langzeitpatienten, haben es aufgegeben, auf ärztliche Hilfe zu hoffen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1K69vYF via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In […]
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Echinocandin resistance in Candida glabrata is emerging and is associated with the presence of FKS mutations. In this study, we analysed the antifungal susceptibility, presence of FKS mutations and clonality of C. glabrata blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 C. glabrata bloodstream isolates from two university […]
Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this […]
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (n = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, in vitro susceptibility and […]
AAP Publications Reaffirmed or Retired
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1JwYPlV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OJ3f88 via IFTTT
Prevention and Management of Procedural Pain in the Neonate: An Update
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The prevention of pain in neonates should be the goal of all pediatricians and health care professionals who work with neonates, not only because it is ethical but also because repeated painful exposures have the potential for deleterious consequences. Neonates at greatest risk of neurodevelopmental impairment as a result of preterm birth (ie, the smallest […]
Chronic Fatigue Syndrome at Age 16 Years
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
BACKGROUND: In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity. METHODS: ALSPAC data were used to estimate the prevalence of chronic fatigue syndrome (CFS) at age 16 […]
Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this […]
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Echinocandin resistance in Candida glabrata is emerging and is associated with the presence of FKS mutations. In this study, we analysed the antifungal susceptibility, presence of FKS mutations and clonality of C. glabrata blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 C. glabrata bloodstream isolates from two university […]
Chronische Urtikaria: Viele behandeln sich lieber selbst
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ATTENTUS-Survey Eine Umfrage unter Patienten mit chronischer Urtikaria zeichnet ein düsteres Bild der Versorgunglage in Deutschland. Viele, darunter drei von vier Langzeitpatienten, haben es aufgegeben, auf ärztliche Hilfe zu hoffen. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1K69vYF via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JwZzY5 via IFTTT
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (n = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, in vitro susceptibility and […]
Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak classification of complex renal cysts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Aim To compare contrast-enhanced ultrasound and contrast-enhanced computed tomography in the evaluation of complex renal cysts using the Bosniak classification. Methods Forty-six patients with 51 complex renal cysts were prospectively examined using contrast-enhanced ultrasound and contrast-enhanced computed tomography and images analysed by two observers using the Bosniak classification. Adverse effects and patients’ preference were assessed […]
Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Background Sorbitan sesquioleate (SSO) has been added to fragrance mix I (FM I) as an emulsifier since the 1990s. Being a contact allergen itself, SSO has the potential to cause false-positive reactions to FM I. Recent results obtained with selected FM I-positive patients have shown that 5% have concomitant positive reactions to SSO. Objectives […]
Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Background Essential oils are fragrance substances that are labelled on cosmetic products by their INCI names, potentially confusing consumers. Objectives To establish whether contact allergy to essential oils might be missed if not specifically tested for. Methods We tested 471 patients with 14 essential oils and 2104 patients with Melaleuca alternifolia oil between January […]
Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients
Summary Background Sorbitan sesquioleate (SSO) has been added to fragrance mix I (FM I) as an emulsifier since the 1990s. Being a contact allergen itself, SSO has the potential to cause false-positive reactions to FM I. Recent results obtained with selected FM I-positive patients have shown that 5% have concomitant positive reactions to SSO. Objectives… Continue reading Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients
Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series
Summary Background Essential oils are fragrance substances that are labelled on cosmetic products by their INCI names, potentially confusing consumers. Objectives To establish whether contact allergy to essential oils might be missed if not specifically tested for. Methods We tested 471 patients with 14 essential oils and 2104 patients with Melaleuca alternifolia oil between January… Continue reading Contact allergy to essential oils cannot always be predicted from allergy to fragrance markers in the baseline series
Language skills and phonological awareness in children with cochlear implants and normal hearing
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Zahra Soleymani, Najmeh Mahmoodabadi, Mina Mohammadi Nouri ObjectivesEarly auditory experience plays a major role in language acquisition. Linguistic and metalinguistic abilities of children aged 5 to 5.5 years with cochlear implants (CIs) were compared to age-matched children with normal hearing (NH) to… Continue reading Language skills and phonological awareness in children with cochlear implants and normal hearing
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: which method has more benefit on clinic?
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Aylin Eryilmaz, Yesim Basal from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PwF3mJ via IFTTT
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: A novel predictor or fad?
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Mehmet Akif Abakay, Timur Ekiz, Ahmet Cemal Pazarlı from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PwF5Lc via IFTTT
Congenital nasal pyriform aperture stenosis: Elaboration of a management algorithm from 25 years of experience
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): E. Moreddu, C. L.E. Treut-Gay, J.M. Triglia, R. Nicollas IntroductionCongenital nasal pyriform aperture stenosis (CNPAS) is a rare disease presenting with neonatal respiratory distress, often associated with other anomalies.Materials and methodsThis study reports the clinical and radiological characteristics of the patients managed… Continue reading Congenital nasal pyriform aperture stenosis: Elaboration of a management algorithm from 25 years of experience
Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks
Publication date: May 2016 Source:International Journal of Biological Macromolecules, Volume 86 Author(s): Rania A. Hashad, Rania A.H. Ishak, Sherif Fahmy, Samar Mansour, Ahmed S. Geneidi At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable… Continue reading Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks
Lecithin-gold hybrid nanocarriers as efficient and pH selective vehicles for oral delivery of diacerein—In-vitro and in-vivo study
Publication date: 1 May 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 141 Author(s): Ibrahim Javed, Syed Zajif Hussain, Atif Shahzad, Jahanzeb Muhammad Khan, Habib ur-Rehman, Mubashar Rehman, Faisal Usman, Muhammad Tahir Razi, Muhammad Raza Shah, Irshad Hussain We report the synthesis and evaluation of lecithin-gold hybrid nanocarriers for the oral delivery of drugs with improved… Continue reading Lecithin-gold hybrid nanocarriers as efficient and pH selective vehicles for oral delivery of diacerein—In-vitro and in-vivo study
First isolation and antinociceptive activity of a lipid transfer protein from noni (Morinda citrifolia) seeds
Publication date: May 2016 Source:International Journal of Biological Macromolecules, Volume 86 Author(s): Dyély C.O. Campos, Andrea S. Costa, Amanda D.R. Lima, Fredy D.A. Silva, Marina D.P. Lobo, Ana Cristina O. Monteiro-Moreira, Renato A. Moreira, Luzia K.A.M. Leal, Diogo Miron, Ilka M. Vasconcelos, Hermógenes D. Oliveira In this study a novel heat-stable lipid transfer protein, designated… Continue reading First isolation and antinociceptive activity of a lipid transfer protein from noni (Morinda citrifolia) seeds
Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues
Abstract Renal pacemaker activity triggers peristaltic upper urinary tract contractions that propel waste from the kidney to the bladder, a process prone to congenital defects that are the leading cause of pediatric kidney failure. Recently, studies have discovered that hyperpolarization-activated cation (HCN) and T-type calcium (TTC) channel conductances underlie murine renal pacemaker activity, setting the… Continue reading Hyperpolarization-activated cation and T-type calcium ion channel expression in porcine and human renal pacemaker tissues
A chronic care ostomy self-management program for cancer survivors
Abstract Background Individuals with ostomies experience extensive changes in health-related quality of life (HRQOL) and daily routine. Patients and families are typically forced to use trial and error to improve self-management. Methods This is a longitudinal one-group design pilot study of a five-session ostomy self-care curriculum based on the Chronic Care Model to improve HRQOL and self-management for cancer survivors with ostomies. Participants were surveyed to evaluate each session. Multiple instruments were administered to examine outcomes at baseline, post-intervention, a... περισσότερα »
Cancer patients' referral wish: effects of distress, problems, socio-demographic and illness-related variables and social support sufficiency
Abstract Background The present study's aim was to examine effects of cancer patients' perceived distress and problems, socio-demographic and illness-related variables and social support sufficiency on referral wish. Methods A cross-sectional group of 1340 patients (response = 51%) completed a questionnaire consisting of the Dutch version of the Distress Thermometer and Problem List, including the referral wish question, and questions on socio-demographic and illness-related variables and perceived social support sufficiency. Univariate and multivariate analyses were performed to... περισσότερα »
Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I–III esophageal cancer
Abstract The effect of proton beam therapy (PBT) on various cancers is controversial. We aimed to evaluate the efficacy and safety of PBT with alternating chemoradiotherapy (ACRT) for patients with stage I–III esophageal cancer. Two cycles of systemic chemotherapy with a continuous infusion of 5-fluorouracil (5-FU) on days 1–5 and a 5h infusion of nedaplatin (NDP) on day 6 were accompanied by thoracic irradiation using X-ray therapy and PBT. During the first half of the treatment, X-rays were delivered to the prophylactic area. During the second half of the treatment, proton beams... περισσότερα »
Cells, Vol. 5, Pages 4: Feedback Regulation of Kinase Signaling Pathways by AREs and GREs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In […]
Echinocandin resistance and population structure of invasive Candida glabrata isolates from two university hospitals in Germany and Austria
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Echinocandin resistance in Candida glabrata is emerging and is associated with the presence of FKS mutations. In this study, we analysed the antifungal susceptibility, presence of FKS mutations and clonality of C. glabrata blood culture isolates from two hospitals in Germany and Austria. Susceptibility testing of 64 C. glabrata bloodstream isolates from two university […]
Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this […]
Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Candidemia remains a major cause of disease worldwide and is associated with a high mortality rate. We conducted a retrospective study of candidemia at Nantes Hospital, France, between 2004 and 2010. A total of 191 episodes (n = 188 patients) were reviewed. Incidence, demographics, risk factors, antifungal management, species identification, in vitro susceptibility and […]
Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak classification of complex renal cysts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aim To compare contrast-enhanced ultrasound and contrast-enhanced computed tomography in the evaluation of complex renal cysts using the Bosniak classification. Methods Forty-six patients with 51 complex renal cysts were prospectively examined using contrast-enhanced ultrasound and contrast-enhanced computed tomography and images analysed by two observers using the Bosniak classification. Adverse effects and patients’ preference were assessed […]
Prospective comparison of use of contrast-enhanced ultrasound and contrast-enhanced computed tomography in the Bosniak classification of complex renal cysts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Aim To compare contrast-enhanced ultrasound and contrast-enhanced computed tomography in the evaluation of complex renal cysts using the Bosniak classification. Methods Forty-six patients with 51 complex renal cysts were prospectively examined using contrast-enhanced ultrasound and contrast-enhanced computed tomography and images analysed by two observers using the Bosniak classification. Adverse effects and patients’ preference were assessed […]
Language skills and phonological awareness in children with cochlear implants and normal hearing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Zahra Soleymani, Najmeh Mahmoodabadi, Mina Mohammadi Nouri ObjectivesEarly auditory experience plays a major role in language acquisition. Linguistic and metalinguistic abilities of children aged 5 to 5.5 years with cochlear implants (CIs) were compared to age-matched children with normal hearing (NH) to […]
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: which method has more benefit on clinic?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Aylin Eryilmaz, Yesim Basal from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PwF3mJ via IFTTT
Neutrophil to lymphocyte ratio for evaluating the viscosity of otitis media with effusion: A novel predictor or fad?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Mehmet Akif Abakay, Timur Ekiz, Ahmet Cemal Pazarlı from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PwF5Lc via IFTTT
Congenital nasal pyriform aperture stenosis: Elaboration of a management algorithm from 25 years of experience
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 25 January 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): E. Moreddu, C. L.E. Treut-Gay, J.M. Triglia, R. Nicollas IntroductionCongenital nasal pyriform aperture stenosis (CNPAS) is a rare disease presenting with neonatal respiratory distress, often associated with other anomalies.Materials and methodsThis study reports the clinical and radiological characteristics of the patients managed […]
Histopathological comparison of the onset of peri-implantitis and periodontitis in rats
[image: cover.gif?v=1&s=be74442fea687c39b7fdfa63] Abstract Background and objective There are a few experimental models that clearly describe the pathological differences in tissue destruction between periodontitis and peri-implantitis. We recently reported that the formation of immune complexes accelerates site-specific loss of attachment and alveolar bone resorption when an antigen is topically applied in the gingival sulcus of an immunized rat. We applied this model to the peri-implant tissues and compared peri-implant destruction to periodontitis without using a ligature. Mat... περισσότερα »
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου