Loss of recent memory after bilateral hippocampal lesions
Loss of recent memory after bilateral hippocampal lesions: memory and memories--looking back and looking forward: In 1957, Scoville and Milner reported a series of case studies describing the nature of the memory defect they observed following bilateral surgical removals from the medial temporal region. The paper highlighted that extensive bilateral surgical excisions from the hippocampus and hippocampal gyrus resulted in severe and lasting memory loss; it also focused attention on these brain structures as critical for the maintenance of normal memory function. These findings ran...περισσότερα »
Association between Parkinson's disease (PD) and melanoma
Frequency and profile of Parkinson's disease prodromi in patients with malignant melanoma: Objective The results of register studies suggest an association between Parkinson's disease (PD) and melanoma. We studied the frequency and profile of early markers of PD in patients with malignant melanoma. Methods 100 participants were enrolled in a prospective observational study, of whom 65 had a history of high-risk cutaneous (n=53) or uveal (n=12) melanoma (31 women; age, 61.2±14.9 years) and another 35 served as control participants (19 women; 54.6±20.5 years). Participants underwent ...περισσότερα »
White matter hyperintensities (WMH) are a common radiographic finding and may be a useful endophenotype for small vessel diseases
Candidate-gene analysis of white matter hyperintensities on neuroimaging: Background White matter hyperintensities (WMH) are a common radiographic finding and may be a useful endophenotype for small vessel diseases. Given high heritability of WMH, we hypothesised that certain genotypes may predispose individuals to these lesions and consequently, to an increased risk of stroke, dementia and death. We performed a meta-analysis of studies investigating candidate genes and WMH to elucidate the genetic susceptibility to WMH and tested associated variants in a new independent WMH cohort... περισσότερα »
Improving fMRI reliability in presurgical mapping for brain tumours
Improving fMRI reliability in presurgical mapping for brain tumours: Purpose Functional MRI (fMRI) is becoming increasingly integrated into clinical practice for presurgical mapping. Current efforts are focused on validating data quality, with reliability being a major factor. In this paper, we demonstrate the utility of a recently developed approach that uses receiver operating characteristic-reliability (ROC-r) to: (1) identify reliable versus unreliable data sets; (2) automatically select processing options to enhance data quality; and (3) automatically select individualised thre... περισσότερα »
Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort
Identifying who will benefit from non-invasive ventilation in amyotrophic lateral sclerosis/motor neurone disease in a clinical cohort: Background Respiratory failure is associated with significant morbidity and is the predominant cause of death in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). This study aimed to determine the effect of non-invasive ventilatory (NIV) support on survival and pulmonary function decline across MND/ALS phenotypes. Methods Cohort recruited via a specialist, multidisciplinary clinic. Patients were categorised into four clinical phenotype... περισσότερα »
Clinical outcomes and risk factors for posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a multicentric case-control study
Clinical outcomes and risk factors for posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a multicentric case-control study: Background Posterior reversible encephalopathy syndrome (PRES) is a well-known but rare complication in patients (<1%) with systemic lupus erythematosus (SLE). However, current epidemiological data are quite scant. The aim of the present study was to describe potentially unrecognised risk factors. Patients and methods We performed a multicentre, retrospective case–control study in Mexico between 1999 and 2014. We included a total of...περισσότερα »
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies
Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies: Cancer stem cells (CSCs) are a unique subset of cells within tumors with stemlike properties that have been proposed to be key drivers of tumor initiation and progression. CSCs are functionally defined by their unlimited self-renewal capacity and their ability to initiate tumor formation in vivo. Like normal stem cells, CSCs exist in a cellular niche comprised of numerous cell types including tumor-associated macrophages (TAMs) which provides a unique microenvironment to protect and promote ... περισσότερα »
A 16-year-old boy presented with complaints of recent onset difficulty in walking, progressive diminution of vision and a long-standing persistent occipital headache : Lhermitte-Duclos disease
*Lhermitte-Duclos disease: Description* *A 16-year-old boy presented with complaints of recent onset difficulty in walking, progressive diminution of vision and a long-standing persistent occipital headache. Physical examination suggested cerebellar ataxia, positive cerebellar signs, macrocephaly and bilateral papilloedema. MRI of the brain revealed a mass lesion with prominent striated folial pattern involving the right cerebellar hemisphere and causing obstructive hydrocephalus. The lesion appeared hypointense on T1 (figure 1) and hyperintense on T2 (figure 2) weighted images, wit... περισσότερα »
Issue Information – TOC
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1VgtMvx via IFTTT
Utility of folate receptor alpha immunohistochemistry in cytology specimens of metastatic breast carcinoma, metastatic serous carcinoma of Müllerian origin, and primary lung adenocarcinoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Background Folate receptor alpha (FRA) overexpression by immunohistochemistry (IHC) has been shown to various degrees in histologic specimens from breast ductal carcinoma (DC), serous carcinoma of Müllerian origin (SCM), and primary lung adenocarcinoma (ADC) among others. Antifolate therapies have recently shown usefulness in FRA overexpressing malignancies. We assessed the feasibility for detecting FRA overexpression by IHC in cytologic cell blocks (CB) from the aforementioned carcinomas. Method Cases of breast DC, SCM and lung ADC were included. The CB were immunostained with ... περισσότερα »
Unsuccessful coil embolisation in Osler-Weber-Rendu syndrome
Long-term follow-up of unsuccessful coil embolisation in Osler-Weber-Rendu syndrome: Description A 22-year-old woman was referred for management of intermittent haemoptysis. She had been diagnosed with hereditary haemorrhagic telangiectasia (HHT) when she was 5 years old and had undergone coil embolisation for treatment of pulmonary arteriovenous malformation (PAVM) at the ages of 6, 11 and 21 years. CT of the chest revealed multiple areas of PAVM and enhanced consolidation confined to the left lower lobe, and a large PAVM in the area that was previously coiled (figure 1). Pulmonary... περισσότερα »
Micromachines, Vol. 7, Pages 30: CMOS-NEMS Copper Switches Monolithically Integrated Using a 65 nm CMOS Technology
This work demonstrates the feasibility to obtain copper nanoelectromechanical (NEMS) relays using a commercial complementary metal oxide semiconductor (CMOS) technology (ST 65 nm) following an intra CMOS-MEMS approach. We report experimental demonstration of contact-mode nano-electromechanical switches obtaining low operating voltage (5.5 V), good ION/IOFF (103) ratio, abrupt subthreshold swing (4.3 mV/decade) and minimum dimensions (3.50 μm × 100 nm × 180 nm, and gap of 100 nm). With these dimensions, the operable Cell area of the switch will be 3.5 μm (length) × 0.2 μm (100 nm w... περισσότερα »
Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection
Abstract Background Members of triggering receptor expressed on myeloid cells (TREM) family are known as immunmodulators in several infectious or noninfectious inflammatory disorders. The information about their role in viral infections is very limited. To enlighten if there's a relation between soluble TREM-1(sTREM-1) and a viral infection, Crimean Congo Haemorrhagic Fever (CCHF). Methods We investigated the levels of sTREM-1 in the sera of 39 CCHF patients both at admission and at recovery and compared with 40 healthy controls by using microELISA technique. Statistical analysi...περισσότερα »
Oligonucleotide-functionalized carbon nanotubes chemiresistor for sensitive detection of mercury in saliva
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00018E, Paper Dawit N Wordofa, Pankaj Ramnani, Thien Toan Tran, Ashok Mulchandani Divalent mercuric (Hg2+) ion and monomethyl mercury (CH3Hg+) are two forms of mercury that are known to be highly toxic to humans. In this work, we present a highly selective,... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1TiAsKh Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Quantitative analysis of iontophoretic drug delivery from micropipettes
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02530C, Paper R M Wightman, Douglas C Kirkpatrick, Lindsay R Walton, Martin Andrew Edwards Microiontophoresis is a drug delivery method in which an electric current is used to eject molecular species from a micropipette. It has been primarily utilized for neurochemical investigations, but is... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1TiAq5m Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel ... περισσότερα »
Editorial Board
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 from #Medicine via ola Kala on Inoreader http://ift.tt/1SrOL0h Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Special Issue Content Lists
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 from #Medicine via ola Kala on Inoreader http://ift.tt/214kS7N Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): P.R. Jungblut, B. Thiede, H. Schlüter from #Medicine via ola Kala on Inoreader http://ift.tt/1SrOKcU Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Protein species as diagnostic markers
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Pascal Steffen, Marcel Kwiatkowski, Wesley D. Robertson, Arash Zarrine-Afsar, Diana Deterra, Verena Richter, Hartmut Schlüter Many diseases are associated with protein species perturbations. A prominent example of an established diagnostic marker is the glycated protein species of hemoglobin, termed HbA1c. HbA1c concentration is increased in the blood of diabetes mellitus patients due to their poor control of blood glucose levels resulting in an increased non-enzymatic glycosylation of hemoglobi...περισσότερα »
Biological significance of co- and post-translational modifications of the yeast 26S proteasome
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Hisashi Hirano, Yayoi Kimura, Ayuko Kimura In yeast (Saccharomyces cerevisiae), co- and post-translational modifications of the 26S proteasome, a large protein complex, were comprehensively detected by proteomic techniques, and their functions were investigated. The presence, number, site, and state of co- and post-translational modifications of the 26S proteasome differ considerably among yeast, human, and mouse. The roles of phosphorylation, Nα-acetylation, Nα-myristoylation, Nα-methylation, a...περισσότερα »
Hexose-derived glycation sites in processed bovine milk
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Sanja Milkovska-Stamenova, Ralf Hoffmann Milk products are consumed by many people on a daily basis, which demands sophisticated technical processes to guarantee the microbiological safety and to retain the nutritional value. The heating during pasteurization and ultra high temperature (UHT) treatment triggers diverse chemical reactions, such as the reaction of sugars and amino groups of proteins typically termed protein glycation. The glycation by lactose as dominant sugar in milk has been rece...περισσότερα »
Protein species-specific characterization of conformational change induced by multisite phosphorylation
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Jingxi Pan, Suping Zhang, Christoph H. Borchers Phosphorylation is a central mechanism for regulating the structure and function of proteins in the cell, but accurate characterization of a specific protein phospho-species is challenging due to the difficulty of separating it from other species, as well as the limitations of the traditional structural methods. By using selective top-down ETD, we were able to identify six specific phospho-species of calmodulin (CaM). Phosphorylation of CaM at four... περισσότερα »
A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Catherine Aude-Garcia, Bastien Dalzon, Jean-Luc Ravanat, Véronique Collin-Faure, Hélène Diemer, Jean Marc Strub, Sarah Cianferani, Alain Van Dorsselaer, Marie Carrière, Thierry Rabilloud The cellular responses of the J774 macrophage cell line to zinc oxide and zirconium oxide nanoparticles have been studied by a comparative quantitative, protein level based proteomic approach. The most prominent results have been validated by targeted approaches. These approaches have been carried out under cult...περισσότερα »
Differentiation of protein species of alpha-2u-globulin according to database entries: A half-theoretical approach
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Sevil Aksu, Fatmagül Tanrikulu The alpha-2u-globulin protein, the main subject of this study, is the most abundant protein in adult male rat urine. In this investigation there are 19 spots identified as alpha-2u-globulin by 2-DE and MALDI-TOF/TOF-MS. All of them are in the low molecular weight region, at approximately 15–25kDa. Searches within both, SwissProt and NCBI databases gave different from each other, but on the majority the same database entry as the highest ranked result for all spots.... περισσότερα »
Homogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): M. Kwiatkowski, M. Wurlitzer, A. Krutilin, P. Kiani, R. Nimer, M. Omidi, A. Mannaa, T. Bussmann, K. Bartkowiak, S. Kruber, S. Uschold, P. Steffen, J. Lübberstedt, N. Küpker, H. Petersen, R. Knecht, N.O. Hansen, A. Zarrine-Afsar, W.D. Robertson, R.J.D. Miller, H. Schlüter Posttranslational modifications and proteolytic processing regulate almost all physiological processes. Dysregulation can potentially result in pathologic protein species causing diseases. Thus, tissue species proteomes of disea... περισσότερα »
IJMS, Vol. 17, Pages 239: Food-Derived Bioactives Can Protect the Anti-Inflammatory Activity of Cortisol with Antioxidant-Dependent and -Independent Mechanisms
In chronic inflammatory diseases the anti-inflammatory effect of glucocorticoids (GCs) is often decreased, leading to GC resistance. Inflammation is related with increased levels of reactive oxygen species (ROS), leading to oxidative stress which is thought to contribute to the development of GC resistance. Plant-derived compounds such as flavonoids are known for their ability to protect against ROS. In this exploratory study we screened a broad range of food-derived bioactives for their antioxidant and anti-inflammatory effects in order to investigate whether their antioxidant ef... περισσότερα »
A review of the proposed role of neutrophils in rodent amebic liver abscess models
Authors: Rafael Campos-Rodríguez, Manuel Gutiérrez-Meza, Rosa Adriana Jarillo-Luna, María Elisa Drago-Serrano, Edgar Abarca-Rojano, Javier Ventura-Juárez, Luz María Cárdenas-Jaramillo and Judith Pacheco-Yepez.<br>Parasite Vol. 23 , page 6<br>Published online: 15/02/2016<br> Keywords: Amoebic liver abscess ; Rodents ; Neutrophil activation ; Reactive oxygen and nitrogen species ; Peroxynitrite ; Neutrophil extracellular traps.<img src="http://ift.tt/1LppGvA" height="1" width="1" alt=""> from #Medicine via ola Kala on Inoreader http://ift.tt/1oiKikg Medicine by Alexandros G.S... περισσότερα »
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (*FAT1*) and determine the prognostic significance of *FAT1* mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. *FAT1* mutational status was determined in 234 and 37 pati... περισσότερα »
Exercise therapy for trismus secondary to head and neck cancer: A systematic review
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. Methods Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Results Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching techniques, duration of stretch, and repetition of exercises was found. The overall quality was moderate. Five of the 8 preventive studies ...περισσότερα »
Management of toxicities of immune checkpoint inhibitors.
Related Articles *Management of toxicities of immune checkpoint inhibitors.* Cancer Treat Rev. 2016 Feb 6;44:51-60 Authors: Spain L, Diem S, Larkin J Abstract Immune checkpoint inhibition with the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibodies nivolumab and pembrolizumab has improved survival in metastatic melanoma, lung cancer and renal cancer. Use of these agents holds promise in other malignancies. The augmented immune response enabled by these agents has led to a particular group of side effects called immune-related adverse events (irAEs). The main irAEs includ...περισσότερα »
Stereotactic Approach Combined with 3D CT Reconstruction for Difficult-to-Access Foramen Ovale on Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia.
Related Articles *Stereotactic Approach Combined with 3D CT Reconstruction for Difficult-to-Access Foramen Ovale on Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia.* Pain Med. 2016 Feb 13; Authors: Guo Z, Wu B, Du C, Cheng M, Tian Y Abstract OBJECTIVES: The authors describe a technique that includes a stereotactic approach in the preoperative plan in cases where the foramen ovale is difficult to access for radiofrequency thermocoagulation of the Gasserian ganglion. METHODS: The study included 395 patients for whom three-dimensional computed to... περισσότερα »
Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.
Related Articles *Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.* Pathol Oncol Res. 2016 Feb 13; Authors: Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck regions and accounts for more than 90 % of cancers in the oral cavity. S-phase kinase-associated protein-2 (Skp2) is a member of the F-box protein family and the substrate recognition subunit of the Skp1-Cullin-F box ... περισσότερα »
Dynamic subcellular localization of estrogen receptor alpha during the first two cleavages of mouse preimplantation embryos.
Related Articles *Dynamic subcellular localization of estrogen receptor alpha during the first two cleavages of mouse preimplantation embryos.* Acta Histochem. 2016 Feb 10; Authors: Xu S, Lian X, Cheng X, Song C, He L, Liu Y, Chen J, Du J, Pang L, Wang S Abstract Zygotic gene activation (ZGA) is one of the most important events after mouse fertilization, but the mechanisms underpinning it are still unclear. Estrogen receptor alpha (ERα) is a versatile player in animal development. Our preliminary studies showed that ERα-specific antagonists blocked mouse 2-cell development and i... περισσότερα »
Nonsteroidal Anti-Inflammatory Drugs Quickly Resolve Symptoms Associated with EBV-Induced Infectious Mononucleosis in Patients with Atopic Predispositions.
Related Articles *Nonsteroidal Anti-Inflammatory Drugs Quickly Resolve Symptoms Associated with EBV-Induced Infectious Mononucleosis in Patients with Atopic Predispositions.* Am J Case Rep. 2016;17:84-88 Authors: Kazama I, Miura C, Nakajima T Abstract BACKGROUND Infectious mononucleosis is a clinical syndrome most commonly associated with primary Epstein-Barr virus (EBV) infection. In adults, the symptoms can often be severe and prolonged, sometimes causing serious complications. Analgesic or antipyretic drugs are normally used to relieve the symptoms. However, there is no causa... περισσότερα »
Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction.
Related Articles *Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction.* J Am Acad Dermatol. 2016 Feb 10; Authors: Gibson JF, Huang J, Liu KJ, Carlson KR, Foss F, Choi J, Edelson R, Hussong JW, Mohl R, Hill S, Girardi M Abstract BACKGROUND: Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is important for early detection, prognosis, and monitoring disease burden. OBJECTIVE: We sought to determine the spectrum of current clinical practices; ... περισσότερα »
Chemotherapy at First Diagnosis of Advanced Prostate Cancer - Revolution or Evolution? Findings from a British Uro-oncology Group UK Survey to Evaluate Oncologists' Views on First-line Docetaxel in Combination with Androgen Deprivation Therapy in Castrate-sensitive Metastatic and High-risk/Locally Advanced Prostate Cancer.
Related Articles *Chemotherapy at First Diagnosis of Advanced Prostate Cancer - Revolution or Evolution? Findings from a British Uro-oncology Group UK Survey to Evaluate Oncologists' Views on First-line Docetaxel in Combination with Androgen Deprivation Therapy in Castrate-sensitive Metastatic and High-risk/Locally Advanced Prostate Cancer.* Clin Oncol (R Coll Radiol). 2016 Feb 10; Authors: Davda R, Hughes S, Jones R, Crabb SJ, Troup J, Payne H Abstract AIMS: There have been three randomised trials investigating docetaxel in combination with androgen deprivation therapy as first-... περισσότερα »
Grading of Prostate Cancer: Past, Present, and Future.
Related Articles *Grading of Prostate Cancer: Past, Present, and Future.* Curr Urol Rep. 2016 Mar;17(3):25 Authors: Matoso A, Epstein JI Abstract The grading of prostate cancer has undergone significant changes since the adoption of the Gleason grading system in the 1970s. Gleason patterns 1 and 2 are no longer in use and the current Gleason score 6 of 10 is the lowest grade possible. Several specific morphologies that were historically considered Gleason grade 3 are currently assigned a Gleason pattern 4. Consequently, current Gleason score 6 cancers have a better prognosis than... περισσότερα »
Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies.
Related Articles *Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies.* Oral Maxillofac Surg. 2016 Feb 13; Authors: Grimm M, Hoefert S, Krimmel M, Biegner T, Feyen O, Teriete P, Reinert S Abstract INTRODUCTION: One of the common malignant tumors of the head and neck worldwide with generally unfavorable prognosis is squamous cell carcinoma (OSCC) of the oral cavity. Early detection of primary, secondary, or recurrent OSCC by liquid biopsy tools is much needed. CASE PRESENTATION: Twelve blood biomark... περισσότερα »
The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.
Related Articles *The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.* Rhinology. 2016 Feb 14; Authors: Kim JS, Oh JS, Kwon SH Abstract BACKGROUND AND OBJECTIVES: Sinonasal organized hematoma is a rare, benign disease that can be locally aggressive and may be mistaken for malignancy. Because of its rarity, the clinical characteristics are not well known. The aim of this study is to investigate the distinguishing features of organized hematoma with an emphasis on incidence change. MATERIALS AND METHODS: In this retrospect... περισσότερα »
Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?
Related Articles *Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Rosito LP, Teixeira AR, Netto LS, Selaimen FA, da Costa SS Abstract The objective of this is to verify whether the hearing impairment caused by posterior epitympanic differed from that caused by posterior mesotympanic cholesteatomas by a cross-sectional study. We evaluated 264 ears of patients with cholesteatoma, who had not been subjected to ear surgery. Otoendoscopy and pure-t...περισσότερα »
Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey.
Related Articles *Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Schiller U, Inhestern J, Burger U, Singer S, Guntinas-Lichius O Abstract Predictors for smoking and alcohol drinking behavior were investigated in head and neck cancer survivors (HNCS) with survivorship of ≥6 months. 165 HNCS registered in a regional cancer registry and treated 2005-2014 were included. Patients completed a survey including the Fagerström Test for nicotine dependence ... περισσότερα »
Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.
Related Articles *Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S Abstract We sought to evaluate the efficacy and feasibility of superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (hereafter RADPLAT) for head and neck squamous cell cancer (hereafter HNSCC) patients with retrop...περισσότερα »
Nodal yield of neck dissections and influence on outcome in laryngectomized patients.
Related Articles *Nodal yield of neck dissections and influence on outcome in laryngectomized patients.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Böttcher A, Dommerich S, Sander S, Olze H, Stromberger C, Coordes A, Jowett N, Knopke S Abstract The appropriate extent of neck dissection (ND) in head and neck squamous cell carcinoma (SCC) continues to be investigated. This study aimed to determine whether the extent of ND as measured by nodal yield (NY) is a prognostic factor in patients undergoing primary total laryngectomy (TL) for advanced laryngeal SCC. A retrospective r...περισσότερα »
Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3.
Related Articles *Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3.* Allergol Int. 2016 Feb 10; Authors: Saito H, Honda K, Asaka C, Ueki S, Ishikawa K Abstract BACKGROUND: The chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved in eosinophil chemotaxis. It is thought that CCR3 plays an important role in the recruitment and activation of eosinophils in nasal polyposis. We examined nasal polyp extract-induced eosinophil chemotaxis and the effect of... περισσότερα »
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy.
Related Articles *Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy.* Oral Oncol. 2016 Feb 10; Authors: Kraaijenga SA, Oskam IM, van Son RJ, Hamming-Vrieze O, Hilgers FJ, van den Brekel MW, van der Molen L Abstract OBJECTIVES: Assessment of long-term objective and subjective voice, speech, articulation, and quality of life in patients with head and neck cancer (HNC) treated with concurrent chemoradiotherapy (CRT) for advanced, stage IV disease. MATERIALS AND METHODS: Twenty-two disease-free survivo...περισσότερα »
Patient derived xenografts as tools in pharmaceutical development.
Related Articles *Patient derived xenografts as tools in pharmaceutical development.* Clin Pharmacol Ther. 2016 Feb 13; Authors: Izumchenko E, Meir J, Bedi A, Wysocki PT, Hoque M, Sidransky D Abstract Successful drug development in Oncology is grossly suboptimal, manifested by the very low percentage of new agents being developed that ultimately succeed in clinical approval. This poor success is in part due to the inability of standard cell-line xenograft models to accurately predict clinical success and to tailor chemotherapy specifically to a group of patients more likely to be...περισσότερα »
Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor.
Related Articles *Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor.* J Clin Neurosci. 2016 Feb 10; Authors: Singla N, Gupta K, Kapoor A Abstract Gangliogliomas are rare slow growing tumors with a mixed population of dysplastic ganglion cells and glial components, reported at variable sites within the central nervous system, including the frontal, parietal and occipital lobes, the striatum, cerebellum, pituitary and pineal glands as well as the spinal cord. Rarely gangliogliomas have been reported arising within the cranial nerves, including the optic... περισσότερα »
Is high cancer rate in human due to a weakness in biology resulting from the rapid increase in lifetime expectancy?
Related Articles *Is high cancer rate in human due to a weakness in biology resulting from the rapid increase in lifetime expectancy?* Bull Cancer. 2016 Feb 10; Authors: Denis F, Letellier C PMID: 26874976 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1U34DG0 via IFTTT
[Systemic therapies administration for adult patients in neuro-oncology: The standards of the Association of the neuro-oncologists of French expression (ANOCEF)].
Related Articles *[Systemic therapies administration for adult patients in neuro-oncology: The standards of the Association of the neuro-oncologists of French expression (ANOCEF)].* Bull Cancer. 2016 Feb 10; Authors: Simon N, Vasseur M, Chauffert B, Taillandier L, Le Rhun E PMID: 26874975 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1U34Bhr via IFTTT
Patient derived xenografts as tools in pharmaceutical development.
Related Articles *Patient derived xenografts as tools in pharmaceutical development.* Clin Pharmacol Ther. 2016 Feb 13; Authors: Izumchenko E, Meir J, Bedi A, Wysocki PT, Hoque M, Sidransky D Abstract Successful drug development in Oncology is grossly suboptimal, manifested by the very low percentage of new agents being developed that ultimately succeed in clinical approval. This poor success is in part due to the inability of standard cell-line xenograft models to accurately predict clinical success and to tailor chemotherapy specifically to a group of patients more likely to be...περισσότερα »
Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor.
Related Articles *Ganglioglioma arising from olfactory sheath: A rare site of an uncommon tumor.* J Clin Neurosci. 2016 Feb 10; Authors: Singla N, Gupta K, Kapoor A Abstract Gangliogliomas are rare slow growing tumors with a mixed population of dysplastic ganglion cells and glial components, reported at variable sites within the central nervous system, including the frontal, parietal and occipital lobes, the striatum, cerebellum, pituitary and pineal glands as well as the spinal cord. Rarely gangliogliomas have been reported arising within the cranial nerves, including the optic... περισσότερα »
Lhermitte-Duclos disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Description A 16-year-old boy presented with complaints of recent onset difficulty in walking, progressive diminution of vision and a long-standing persistent occipital headache. Physical examination suggested cerebellar ataxia, positive cerebellar signs, macrocephaly and bilateral papilloedema. MRI of the brain revealed a mass lesion with prominent striated folial pattern involving the right cerebellar hemisphere and causing […]
Diseases, Vol. 4, Pages 10: Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Cancer immunotherapy using a patient’s own T cells redirected to recognize and kill tumor cells has achieved promising results in metastatic melanoma and leukemia. This technique involves harnessing a patient’s T cells and then delivering a gene that encodes a new T cell receptor (TCR) or a chimeric antigen receptor (CAR) that allow the cells […]
Merkel cell carcinoma of the head and neck: poorer prognosis than non-head and neck sites
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Research Articles G B Morand, J Madana, S D Da Silva, M P Hier, A M Mlynarek, M J Black The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U34C53 via IFTTT
International Childhood Cancer Day: Much remains to be done to fight childhood cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
New estimates by the International Agency for Research on Cancer (IARC) show that the global occurrence of childhood cancer is higher than previously assessed. These estimates are based on data collected by more than 100 population-based cancer registries in 68 countries around the world in 2001-2010. International Childhood Cancer Day is observed on 15 February […]
Atmosphere, Vol. 7, Pages 28: Sub-Seasonal Prediction of the Maritime Continent Rainfall of Wet-Dry Transitional Seasons in the NCEP Climate Forecast Version 2
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
This study investigates the characteristics and prediction of the Maritime Continent (MC) rainfall for the transitional periods between wet and dry seasons. Several observational data sets and the output from the 45-day hindcast by the U.S. National Centers for Environmental Prediction (NCEP) Climate Forecast System version 2 (CFSv2) are used. Results show that the MC […]
Prävention der Ösophagusvarizenblutung
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Medikation vs. TIPS Leberzirrhotiker mit einer akuten Varizenblutung haben ein hohes Risiko, eine Rezidivblutung zu erleiden, was eine Sekundärprophylaxe notwendig macht. Was ist wirksamer, die Implantation eines transjugulären portosystemischen Stentshunts oder die medikamentösen Reduktion des portalvenösen Drucks? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Tl1IJA via IFTTT
Cancers, Vol. 8, Pages 22: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic […]
Scientists learn how young brains form lifelong memories by studying worms’ food choices
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 8 δευτερόλεπτα
Members of neuroscientist Cori Bargmann’s lab spend quite a bit of their time watching worms move around. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XsQJNl via IFTTT
Predictive biomarker discovery : The effects of four drugs, the PI3K–mammalian target of rapamycin inhibitor dactolisib, the PI3K inhibitor pictrelisib, and the MEK (MAPK/ERK Kinase) inhibitors PD 0325901 and selumetinib, in isogenic DLD1 parental, KRAS+/−, KRASG13D/−, PIK3CA+/− and PIK3CAE545K/− colorectal carcinoma cell lines
Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Emma J. Haagensen, Huw D. Thomas, Clare Mudd, Elpida Tsonou, Ceri M. Wiggins, Ross J. Maxwell, Jonathan D. Moore, David R. Newell Studies to identify predictive biomarkers can be carried out in isogenic cancer cell lines, which enable interrogation of ...περισσότερα »
Malignant peripheral nerve sheath tumors (MPNST)
Management and prognosis of malignant peripheral nerve sheath tumors: The experience of the French Sarcoma Group (GSF-GETO) via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): T. Valentin, A. Le Cesne, I. Ray-Coquard, A. Italiano, G. Decanter, E. Bompas, N. Isambert, J. Thariat, C. Linassier, F. Bertucci, J.O. Bay, A. Bellesoeur, N. Penel, S. Le Guellec, T. Filleron, C. Chevreau BackgroundMalignant peripheral nerve sheath tumors (MPNST) are a rare subtype of soft tissue sarcoma. They can arise i...περισσότερα »
Macrocytosis as a potential parameter associated with survival
Macrocytosis as a potential parameter associated with survival after tyrosine kinase inhibitor treatment via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Jacqueline S.L. Kloth, Paul Hamberg, Pauline A.J. Mendelaar, Roderick R. Dulfer, Bronno van der Holt, Karel Eechoute, Erik A.C. Wiemer, Wim H.J. Kruit, Stefan Sleijfer, Ron H.J. Mathijssen Aim of the studyAs a rise in mean corpuscular volume (MCV) of the erythrocyte is frequently seen during treatment with imatinib and sunitinib, we investi...περισσότερα »
Leptomeningeal metastasis
: Clinical experience of 519 cases via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Jae-Won Hyun, In Hye Jeong, AeRan Joung, Hyo Jin Cho, Su-Hyun Kim, Ho Jin Kim BackgroundDiagnosis of leptomeningeal metastasis (LM) has become increasingly common because of enhanced detection via routine use of magnetic resonance imaging (MRI) and longer survival of patients by better systemic control. We investigated clinical features and analyzed potential prognostic factors in a large cohort of patients w... περισσότερα »
Trabectedin after best supportive care for patients with advanced translocation-related sarcoma
Retrospective inter- and intra-patient evaluation of trabectedin after best supportive care for patients with advanced translocation-related sarcoma after failure of standard chemotherapy via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Nobuhito Araki, Shunji Takahashi, Hideshi Sugiura, Takafumi Ueda, Tsukasa Yonemoto, Mitsuru Takahashi, Hideo Morioka, Hiroaki Hiraga, Toru Hiruma, Toshiyuki Kunisada, Akihiko Matsumine, Akira Kawai AimOur randomised phase II study showed the clinical benefit o... περισσότερα »
Chemoradiotherapy with FOLFOX plus cetuximab in locally advanced oesophageal cancer
: The GERCOR phase II trial ERaFOX via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Gérard Lledo, Florence Huguet, Benoist Chibaudel, Frédéric Di Fiore, Laurent Mineur, Marie-Pierre Galais, Pascal Artru, Valérie Blondin, Olivier Dupuis, Menouar Samir Abdiche, Nicolas Jovenin, Astrid Pozet, Franck Bonnetain, Mohamed Attia, Laetitia Dahan, Aimery de Gramont BackgroundTo determine efficacy and toxicity of radiation therapy combined with oxaliplatin, 5-fluorouracil, and folinic acid (FOLFOX) and ... περισσότερα »
Infantile fibrosarcoma (IFS)
Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience via ScienceDirect Publication: European Journal of Cancer Publication date: April 2016 *Source:*European Journal of Cancer, Volume 57 Author(s): Daniel Orbach, Bernadette Brennan, Angela De Paoli, Soledad Gallego, Peter Mudry, Nadine Francotte, Max van Noesel, Anna Kelsey, Rita Alaggio, Dominique Ranchère, Gian Luca De Salvo, Michela Casanova, Christophe Bergeron, Johannes H.M. Merks, Meriel Jenney, Michael C.G. Stevens, Gianni Bisogno, Andrea Ferrari Backgrou... περισσότερα »
Personalised therapy in head and neck squamous cell carcinoma
Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 55 Author(s): M. Giefing, M. Wierzbicka, K. Szyfter, J.C. Brenner, B.J. Braakhuis, R.H. Brakenhoff, C.R. Bradford, J.A. Sorensen, A. Rinaldo, J.P. Rodrigo, R.P. Takes, A. Ferlito Personalised medicine tumour boards, which leverage genomic data to improve clinical management, are becoming standard for the treatment of many cancers.... περισσότερα »
Oligonucleotide-functionalized carbon nanotubes chemiresistor for sensitive detection of mercury in saliva
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00018E, Paper Dawit N Wordofa, Pankaj Ramnani, Thien Toan Tran, Ashok Mulchandani Divalent mercuric (Hg2+) ion and monomethyl mercury (CH3Hg+) are two forms of mercury that are known to be highly toxic to humans. In this work, we present a highly selective,... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1TiAsKh via IFTTT
Quantitative analysis of iontophoretic drug delivery from micropipettes
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02530C, Paper R M Wightman, Douglas C Kirkpatrick, Lindsay R Walton, Martin Andrew Edwards Microiontophoresis is a drug delivery method in which an electric current is used to eject molecular species from a micropipette. It has been primarily utilized for neurochemical investigations, but is... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1TiAq5m via IFTTT
Editorial Board
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SrOL0h via IFTTT
Special Issue Content Lists
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 from BioChemistry via xlomafota13 on Inoreader http://ift.tt/214kS7N via IFTTT
Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): P.R. Jungblut, B. Thiede, H. Schlüter from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1SrOKcU via IFTTT
Protein species as diagnostic markers
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Pascal Steffen, Marcel Kwiatkowski, Wesley D. Robertson, Arash Zarrine-Afsar, Diana Deterra, Verena Richter, Hartmut Schlüter Many diseases are associated with protein species perturbations. A prominent example of an established diagnostic marker is the glycated protein species of hemoglobin, termed HbA1c. HbA1c concentration is increased in the blood of diabetes mellitus patients due to their poor control of blood glucose levels resulting in an increased non-enzymatic glycosylation of hemoglobi...περισσότερα »
Biological significance of co- and post-translational modifications of the yeast 26S proteasome
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Hisashi Hirano, Yayoi Kimura, Ayuko Kimura In yeast (Saccharomyces cerevisiae), co- and post-translational modifications of the 26S proteasome, a large protein complex, were comprehensively detected by proteomic techniques, and their functions were investigated. The presence, number, site, and state of co- and post-translational modifications of the 26S proteasome differ considerably among yeast, human, and mouse. The roles of phosphorylation, Nα-acetylation, Nα-myristoylation, Nα-methylation, a...περισσότερα »
Hexose-derived glycation sites in processed bovine milk
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Sanja Milkovska-Stamenova, Ralf Hoffmann Milk products are consumed by many people on a daily basis, which demands sophisticated technical processes to guarantee the microbiological safety and to retain the nutritional value. The heating during pasteurization and ultra high temperature (UHT) treatment triggers diverse chemical reactions, such as the reaction of sugars and amino groups of proteins typically termed protein glycation. The glycation by lactose as dominant sugar in milk has been rece...περισσότερα »
Protein species-specific characterization of conformational change induced by multisite phosphorylation
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Jingxi Pan, Suping Zhang, Christoph H. Borchers Phosphorylation is a central mechanism for regulating the structure and function of proteins in the cell, but accurate characterization of a specific protein phospho-species is challenging due to the difficulty of separating it from other species, as well as the limitations of the traditional structural methods. By using selective top-down ETD, we were able to identify six specific phospho-species of calmodulin (CaM). Phosphorylation of CaM at four... περισσότερα »
A combined proteomic and targeted analysis unravels new toxic mechanisms for zinc oxide nanoparticles in macrophages
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Catherine Aude-Garcia, Bastien Dalzon, Jean-Luc Ravanat, Véronique Collin-Faure, Hélène Diemer, Jean Marc Strub, Sarah Cianferani, Alain Van Dorsselaer, Marie Carrière, Thierry Rabilloud The cellular responses of the J774 macrophage cell line to zinc oxide and zirconium oxide nanoparticles have been studied by a comparative quantitative, protein level based proteomic approach. The most prominent results have been validated by targeted approaches. These approaches have been carried out under cult...περισσότερα »
Differentiation of protein species of alpha-2u-globulin according to database entries: A half-theoretical approach
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): Sevil Aksu, Fatmagül Tanrikulu The alpha-2u-globulin protein, the main subject of this study, is the most abundant protein in adult male rat urine. In this investigation there are 19 spots identified as alpha-2u-globulin by 2-DE and MALDI-TOF/TOF-MS. All of them are in the low molecular weight region, at approximately 15–25kDa. Searches within both, SwissProt and NCBI databases gave different from each other, but on the majority the same database entry as the highest ranked result for all spots.... περισσότερα »
Homogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization
Publication date: 16 February 2016 *Source:*Journal of Proteomics, Volume 134 Author(s): M. Kwiatkowski, M. Wurlitzer, A. Krutilin, P. Kiani, R. Nimer, M. Omidi, A. Mannaa, T. Bussmann, K. Bartkowiak, S. Kruber, S. Uschold, P. Steffen, J. Lübberstedt, N. Küpker, H. Petersen, R. Knecht, N.O. Hansen, A. Zarrine-Afsar, W.D. Robertson, R.J.D. Miller, H. Schlüter Posttranslational modifications and proteolytic processing regulate almost all physiological processes. Dysregulation can potentially result in pathologic protein species causing diseases. Thus, tissue species proteomes of disea... περισσότερα »
Constructing Functional Protein Nanotube by Small Molecule-Induced Self-assembly of Cricoid Proteins
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00632A, Communication Lu Miao, Qiusheng Fan, Liulu Zhao, Qinglong Qiao, Xiyu Zhang, Chunxi Hou, Jiayun Xu, Quan Luo, Junqiu Liu A simple strategy has been developed to construct high-ordered protein nanotubes using electrostatic interactions and "Zero-length" crosslinking induced by small molecular, ethylenediamine. Furthermore, utilizing covalent crosslinking, we constructed stable nanoenzymes... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on In... περισσότερα »
Patient-reported outcomes in head and neck and thyroid cancer
randomised controlled trials: A systematic review of completeness of reporting and impact on interpretation via ScienceDirect Publication: European Journal of Cancer Publication date: March 2016 *Source:*European Journal of Cancer, Volume 56 Author(s): Rebecca L. Mercieca-Bebber, Alessandro Perreca, Madeleine King, Andrew Macann, Katie Whale, Salvatore Soldati, Marc Jacobs, Fabio Efficace AimTo determine the completeness of reporting of patient-reported outcomes (PROs) of head and neck cancer (HNC) and thyroid cancer randomised-controlled trials (RCTs) and identify PRO measures used.Me... περισσότερα »
Rolapitant for prevention of chemotherapy-induced nausea and vomiting
Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy via ScienceDirect Publication: European Journal of Cancer Publication date: April 2016 *Source:*European Journal of Cancer, Volume 57 Author(s): Bernardo Rapoport, Lee Schwartzberg, Martin Chasen, Dan Powers, Sujata Arora, Rudolph Navari, Ian Schnadig ObjectiveRolapitant, a novel neurokinin-1 receptor antagonist (RA), was shown to protect against delayed chemotherapy-induced nausea and vomiting (CINV) during the first cycle of... περισσότερα »
Cancer-Induced Bone Pain : Pregabalin Versus Placebo
Randomized Double-Blind Trial of Pregabalin Versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain [Palliative and Supportive Care]: Purpose Cancer-induced bone pain (CIBP) affects one third of patients with cancer. Radiotherapy remains the gold-standard treatment; however, laboratory and clinical work suggest that pregabalin may be useful in treating CIBP. The aim of this study was to examine pregabalin in patients with CIBP receiving radiotherapy. Patients and Methods A multicenter, double-blind randomized trial of pregabalin versus placebo was c...περισσότερα »
Prognostic value of sarcopenia
in adults with solid tumours: A meta-analysis and systematic review via ScienceDirect Publication: European Journal of Cancer Publication date: April 2016 *Source:*European Journal of Cancer, Volume 57 Author(s): Shlomit Strulov Shachar, Grant R. Williams, Hyman B. Muss, Tomohiro F. Nishijima BackgroundBody composition plays an important role in predicting treatment outcomes in adults with cancer. Using existing computed tomographic (CT) cross-sectional imaging and readily available software, the assessment of skeletal muscle mass to evaluate sarcopenia has become simplified. We perfo... περισσότερα »
Open Face Masks for Head and Neck Radiotherapy
A Prospective Evaluation of via Practical Radiation Oncology Publication date: Available online 13 February 2016 *Source:*Practical Radiation Oncology Author(s): David Wiant, Sarah Squire, Han Liu, Jacqueline Maurer, T. Lane Hayes, Benjamin Sintay PurposeHead and neck radiotherapy patients (HN) are typically immobilized with closed thermoplastic masks that cover the face and may cause discomfort for patients. In this work we examine the use of open-masks for HN radiotherapy.Methods and MaterialsFifty HN patients were prospectively randomized into two groups (25 closed-masks, 25 open-m... περισσότερα »
Volumetric-Modulated Arc Therapy to treat Head and Neck Cancer
Robustness Quantification Methods Comparison in via Practical Radiation Oncology Publication date: Available online 13 February 2016 *Source:*Practical Radiation Oncology Author(s): Wei Liu, Samir H. Patel, Jiajian (Jason) Shen, Yanle Hu, Daniel P. Harrington, Xiaoning Ding, Michele Y. Halyard, Steven E. Schild, William W. Wong, Gary A. Ezzell, Martin Bues BackgroundTo compare plan robustness of volumetric-modulated arc therapy (VMAT) with intensity-modulated radiation therapy (IMRT) and to compare the effectiveness of 3 plan robustness quantification methods.MethodsVMAT and IMRT plan... περισσότερα »
Recovery of renal function after long-term dialysis and resolution of cardiomyopathy in a patient with aHUS receiving eculizumab
We present the case of a 18-month-old girl with renal and cardiac manifestations of atypical haemolytic uraemic syndrome (aHUS), and a novel complement factor H mutation. Transient haematological remission was achieved with intensive plasmapheresis, but cardiac function deteriorated and renal function was not restored. Initiation of eculizumab after 6 months of dialysis significantly improved organ function. At 43 months after presentation, haematological values had normalised and cardiac function had improved. Dialysis was discontinued after 10 months (the longest reported time i...περισσότερα »
When is a mass not a mass? An unusual presentation of prominent crista terminalis
This case report describes a patient in whom echocardiography showed borderline left ventricular hypertrophy and a mass adjacent to the right atrial wall. This naturally caused some concern as the differential diagnoses included that of a right atrial myxoma and further investigations were organised. A subsequent cardiac MRI revealed this thickening to be a prominent crista terminalis. The crista terminalis is a variant of normal anatomical structures within the right atrium, which mimics an atrial mass. from Cases via ola Kala on Inoreader http://ift.tt/1KkK7if via IFTTT
Dysuria and fever in a young woman diagnosed as having inflammatory myofibroblastic tumour of the urinary bladder
A 38-year-old woman presented with dysuria and fever. Her medical and family histories were unremarkable. CT scan of the abdomen revealed a polypoid mass of 4x2.6x2.2 cm. Her cystoscopy showed a 4x2 cm solid broad-based growth at trigone of the urinary bladder. She underwent transurethral resection of the urinary bladder tumour (TURBT). Histopathology revealed a poorly circumscribed proliferation of spindle cells arranged in a haphazard and fascicular manner along with many traversing blood vessels in a myxoid and hyalinised stroma. Immunohistochemistry was positive for anaplastic...περισσότερα »
Easily missed fracture: distal radius and concomitant proximal ulna
Description An 8-year-old girl presented to the emergency department following a fall from a climbing frame onto her outstretched left hand. On examination, the left wrist was swollen and tender. The skin was intact with no neurovascular compromise. The patient also reported pain in the left elbow, which was tender on palpation. Anteroposterior and lateral radiographs of the left forearm showed a fracture of the distal radius and proximal ulna (figures 1 and 2). Figure 1 Anteroposterior radiograph of the left forearm showing a distal radius and proximal ulna fracture. Figure 2... περισσότερα »
Lhermitte-Duclos disease
Description A 16-year-old boy presented with complaints of recent onset difficulty in walking, progressive diminution of vision and a long-standing persistent occipital headache. Physical examination suggested cerebellar ataxia, positive cerebellar signs, macrocephaly and bilateral papilloedema. MRI of the brain revealed a mass lesion with prominent striated folial pattern involving the right cerebellar hemisphere and causing obstructive hydrocephalus. The lesion appeared hypointense on T1 (figure 1) and hyperintense on T2 (figure 2) weighted images, with parallel linear striati... περισσότερα »
The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.
Related Articles *The increasing incidence of paranasal organizing hematoma: a 20-year experience of 23 cases at a single center.* Rhinology. 2016 Feb 14; Authors: Kim JS, Oh JS, Kwon SH Abstract BACKGROUND AND OBJECTIVES: Sinonasal organized hematoma is a rare, benign disease that can be locally aggressive and may be mistaken for malignancy. Because of its rarity, the clinical characteristics are not well known. The aim of this study is to investigate the distinguishing features of organized hematoma with an emphasis on incidence change. MATERIALS AND METHODS: In this retrospect... περισσότερα »
Primary school children often underestimate their nasal obstruction.
Related Articles *Primary school children often underestimate their nasal obstruction.* Rhinology. 2016 Feb 14; Authors: Occasi F, Duse M, Vittori T, Rugiano A, Tancredi G, De Castro G, Indinnimeo L, Zicari AM Abstract BACKGROUND: No consensus has ever been reached about the correlation between nasal resistance and the subjective sensation of nasal patency. The aim of the present study was to better de ne whether primary school and secondary school aged children correctly estimate their nasal obstruction. MATERIALS AND METHODS: Two hundred eighty four children (168 males and 116 ... περισσότερα »
Stereotactic Approach Combined with 3D CT Reconstruction for Difficult-to-Access Foramen Ovale on Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia.
Related Articles *Stereotactic Approach Combined with 3D CT Reconstruction for Difficult-to-Access Foramen Ovale on Radiofrequency Thermocoagulation of the Gasserian Ganglion for Trigeminal Neuralgia.* Pain Med. 2016 Feb 13; Authors: Guo Z, Wu B, Du C, Cheng M, Tian Y Abstract OBJECTIVES: The authors describe a technique that includes a stereotactic approach in the preoperative plan in cases where the foramen ovale is difficult to access for radiofrequency thermocoagulation of the Gasserian ganglion. METHODS: The study included 395 patients for whom three-dimensional computed to... περισσότερα »
Injury-Driven Dermal Stiffness Drives cSCC
Injury-Driven Dermal Stiffness Drives cSCC: Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive soft-tissue fibrosis, and a highly elevated risk of early-onset aggressive cutaneous squamous cell carcinoma (cSCC). However, the mechanisms underlying the unusually rapid progression of RDEB to cSCC are unknown. In this study, we investigated the contribution of injury-induced skin alterations to cSCC development by using a genetic model of RDEB and organotypic skin cultures. Analysis of RDEB... περισσότερα »
Imaging Tumor Hypoxia In Vivo with Oxygen-Enhanced MRI
Imaging Tumor Hypoxia In Vivo with Oxygen-Enhanced MRI: There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI (OE-MRI) is an emerging imaging technique for quantifying the spatial distribution and extent of tumor oxygen delivery in vivo. In OE-MRI, the longitudinal relaxation rate of protons (ΔR1) changes in proportion to the concentration of molecular oxygen dissolved in plasma or interstitial tissue fluid. Therefore, well-oxygenated tissues show positive ΔR1. We... περισσότερα »
Role of Macrophages in Wound-Induced Skin Cancer
Role of Macrophages in Wound-Induced Skin Cancer: Macrophages are essential for the progression and maintenance of many cancers, but their role during the earliest stages of tumor formation is unclear. To test this, we used a previously described transgenic mouse model of wound-induced skin tumorigenesis, in which expression of constitutively active MEK1 in differentiating epidermal cells results in chronic inflammation (InvEE mice). Upon wounding, the number of epidermal and dermal monocytes and macrophages increased in wild-type and InvEE skin, but the increase was greater, more r...περισσότερα »
Regulators of invasion: lncRNA functions in migration, EMT and metastasis
From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis: Abstract Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called Epithelial-to-Mesenchymal Transition (EMT). This cellular plasticity seems to drive the initiation of metastasis. Identifying important molecules and understanding their molecular mechanisms is a key to cancer prognosis and th... περισσότερα »
Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness
Abstract Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacies of other medical management regimens is currently available. In this study, we surveyed regimens for EPF that ... περισσότερα »
Traumatic neuroma on the digital tip: Immunohistochemical analysis of inflammatory signaling pathways
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Pustular prurigo pigmentosa treated with doxycycline
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Successful treatment of primary cutaneous Nocardia brasiliensis infection with oral potassium iodide
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Eosinophilic pustular folliculitis: Trends in therapeutic options
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Management of toxicities of immune checkpoint inhibitors.
Related Articles *Management of toxicities of immune checkpoint inhibitors.* Cancer Treat Rev. 2016 Feb 6;44:51-60 Authors: Spain L, Diem S, Larkin J Abstract Immune checkpoint inhibition with the anti-CTLA-4 antibody ipilimumab and the anti-PD-1 antibodies nivolumab and pembrolizumab has improved survival in metastatic melanoma, lung cancer and renal cancer. Use of these agents holds promise in other malignancies. The augmented immune response enabled by these agents has led to a particular group of side effects called immune-related adverse events (irAEs). The main irAEs includ...περισσότερα »
Nodal yield of neck dissections and influence on outcome in laryngectomized patients.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Related Articles *Nodal yield of neck dissections and influence on outcome in laryngectomized patients.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Böttcher A, Dommerich S, Sander S, Olze H, Stromberger C, Coordes A, Jowett N, Knopke S Abstract The appropriate extent of neck dissection (ND) in head and neck squamous cell carcinoma (SCC) continues to be investigated. This study aimed to determine whether the extent of ND as measured by nodal yield (NY) is a prognostic factor in patients undergoing primary total laryngectomy (TL) for advanced laryngeal SCC. A retrospective r...περισσότερα »
Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Related Articles *Monitoring carcinogenesis in a case of oral squamous cell carcinoma using a panel of new metabolic blood biomarkers as liquid biopsies.* Oral Maxillofac Surg. 2016 Feb 13; Authors: Grimm M, Hoefert S, Krimmel M, Biegner T, Feyen O, Teriete P, Reinert S Abstract INTRODUCTION: One of the common malignant tumors of the head and neck worldwide with generally unfavorable prognosis is squamous cell carcinoma (OSCC) of the oral cavity. Early detection of primary, secondary, or recurrent OSCC by liquid biopsy tools is much needed. CASE PRESENTATION: Twelve blood biomark... περισσότερα »
Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?
Related Articles *Cholesteatoma growth patterns: are there audiometric differences between posterior epitympanic and posterior mesotympanic cholesteatoma?* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Rosito LP, Teixeira AR, Netto LS, Selaimen FA, da Costa SS Abstract The objective of this is to verify whether the hearing impairment caused by posterior epitympanic differed from that caused by posterior mesotympanic cholesteatomas by a cross-sectional study. We evaluated 264 ears of patients with cholesteatoma, who had not been subjected to ear surgery. Otoendoscopy and pure-t...περισσότερα »
Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey.
Related Articles *Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Schiller U, Inhestern J, Burger U, Singer S, Guntinas-Lichius O Abstract Predictors for smoking and alcohol drinking behavior were investigated in head and neck cancer survivors (HNCS) with survivorship of ≥6 months. 165 HNCS registered in a regional cancer registry and treated 2005-2014 were included. Patients completed a survey including the Fagerström Test for nicotine dependence ... περισσότερα »
Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.
Related Articles *Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S Abstract We sought to evaluate the efficacy and feasibility of superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (hereafter RADPLAT) for head and neck squamous cell cancer (hereafter HNSCC) patients with retrop...περισσότερα »
Nodal yield of neck dissections and influence on outcome in laryngectomized patients.
Related Articles *Nodal yield of neck dissections and influence on outcome in laryngectomized patients.* Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Böttcher A, Dommerich S, Sander S, Olze H, Stromberger C, Coordes A, Jowett N, Knopke S Abstract The appropriate extent of neck dissection (ND) in head and neck squamous cell carcinoma (SCC) continues to be investigated. This study aimed to determine whether the extent of ND as measured by nodal yield (NY) is a prognostic factor in patients undergoing primary total laryngectomy (TL) for advanced laryngeal SCC. A retrospective r...περισσότερα »
Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.
Related Articles *Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.* Pathol Oncol Res. 2016 Feb 13; Authors: Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck regions and accounts for more than 90 % of cancers in the oral cavity. S-phase kinase-associated protein-2 (Skp2) is a member of the F-box protein family and the substrate recognition subunit of the Skp1-Cullin-F box ... περισσότερα »
Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3.
Related Articles *Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3.* Allergol Int. 2016 Feb 10; Authors: Saito H, Honda K, Asaka C, Ueki S, Ishikawa K Abstract BACKGROUND: The chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved in eosinophil chemotaxis. It is thought that CCR3 plays an important role in the recruitment and activation of eosinophils in nasal polyposis. We examined nasal polyp extract-induced eosinophil chemotaxis and the effect of... περισσότερα »
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy.
Related Articles *Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy.* Oral Oncol. 2016 Feb 10; Authors: Kraaijenga SA, Oskam IM, van Son RJ, Hamming-Vrieze O, Hilgers FJ, van den Brekel MW, van der Molen L Abstract OBJECTIVES: Assessment of long-term objective and subjective voice, speech, articulation, and quality of life in patients with head and neck cancer (HNC) treated with concurrent chemoradiotherapy (CRT) for advanced, stage IV disease. MATERIALS AND METHODS: Twenty-two disease-free survivo...περισσότερα »
Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction.
Related Articles *Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction.* J Am Acad Dermatol. 2016 Feb 10; Authors: Gibson JF, Huang J, Liu KJ, Carlson KR, Foss F, Choi J, Edelson R, Hussong JW, Mohl R, Hill S, Girardi M Abstract BACKGROUND: Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is important for early detection, prognosis, and monitoring disease burden. OBJECTIVE: We sought to determine the spectrum of current clinical practices; ... περισσότερα »
Chemotherapy at First Diagnosis of Advanced Prostate Cancer - Revolution or Evolution? Findings from a British Uro-oncology Group UK Survey to Evaluate Oncologists' Views on First-line Docetaxel in Combination with Androgen Deprivation Therapy in Castrate-sensitive Metastatic and High-risk/Locally Advanced Prostate Cancer.
Related Articles *Chemotherapy at First Diagnosis of Advanced Prostate Cancer - Revolution or Evolution? Findings from a British Uro-oncology Group UK Survey to Evaluate Oncologists' Views on First-line Docetaxel in Combination with Androgen Deprivation Therapy in Castrate-sensitive Metastatic and High-risk/Locally Advanced Prostate Cancer.* Clin Oncol (R Coll Radiol). 2016 Feb 10; Authors: Davda R, Hughes S, Jones R, Crabb SJ, Troup J, Payne H Abstract AIMS: There have been three randomised trials investigating docetaxel in combination with androgen deprivation therapy as first-... περισσότερα »
Grading of Prostate Cancer: Past, Present, and Future.
Related Articles *Grading of Prostate Cancer: Past, Present, and Future.* Curr Urol Rep. 2016 Mar;17(3):25 Authors: Matoso A, Epstein JI Abstract The grading of prostate cancer has undergone significant changes since the adoption of the Gleason grading system in the 1970s. Gleason patterns 1 and 2 are no longer in use and the current Gleason score 6 of 10 is the lowest grade possible. Several specific morphologies that were historically considered Gleason grade 3 are currently assigned a Gleason pattern 4. Consequently, current Gleason score 6 cancers have a better prognosis than... περισσότερα »
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
Cancers, Vol. 8, Pages 22: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors: The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic response have all been shown to be impacted by the Shh signaling pathway....περισσότερα »
Comparing the Effect of Bleach and Water Baths on Skin Barrier Function in Atopic Dermatitis: A Split-Body Randomized Controlled Trial
Comparing the Effect of Bleach and Water Baths on Skin Barrier Function in Atopic Dermatitis: A Split-Body Randomized Controlled Trial: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with defective epidermal barrier function, characterized by decreased stratum corneum (SC) hydration, and increased TEWL (transepidermal water loss) and pH. *Staphylococcus aureus* (SA) skin colonization is present in nearly all cases of AD exacerbation and correlates with disease severity, 1 suggesting an infection – inflammation cycle. The use of sodium hypochlorite (bleach)... περισσότερα »
Chronic sclerotic-type chronic Graft-versus-Host disease and GVHD-associated angiomatosis
Endothelial chimerism in chronic sclerotic-type chronic Graft-versus-Host disease and GVHD-associated angiomatosis: Abstract Graft versus host disease-associated angiomatosis (GVHD-AA) is an uncommon manifestation of chronic graft versus host disease consisting of friable vascular proliferations. Using fluorescent in-situ hybridization, we demonstrate the presence of donor derived endothelial cells within areas of GVHD-AA. This is the first documented occurrence of a benign neoplastic growth in relationship to a form of cGVHD. This article is protected by copyright. All rights reser... περισσότερα »
CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic nevi, and internal malignancies: A case series and review of the literature
CDKN2A mutations with p14 loss predisposing to multiple nerve sheath tumours, melanoma, dysplastic nevi, and internal malignancies: A case series and review of the literature: Abstract An inherited germline mutation in *CDKN2A* is the most common cause of familial atypical multiple mole melanoma syndrome (FAMMM). Although it is well known that *CDKN2A* mutations confer an increased risk for melanoma and pancreatic carcinoma, the association with an increased risk for nerve sheath tumours (NST) and other tumour types is under recognized. We report a family with a missense (c.151-1 C...περισσότερα »
Extensive tumoral melanosis associated with ipilimumab-treated melanoma
Extensive tumoral melanosis associated with ipilimumab-treated melanoma: Abstract Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but that histologically reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumor. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique ca...περισσότερα »
Eosinophilic pustular folliculitis (EPF)
Eosinophilic pustular folliculitis: A published work-based comprehensive analysis of therapeutic responsiveness: Abstract Eosinophilic pustular folliculitis (EPF) is a non-infectious inflammatory dermatosis of unknown etiology that principally affects the hair follicles. There are three variants of EPF: (i) classic EPF; (ii) immunosuppression-associated EPF, which is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF. Oral indomethacin is efficacious, especially for classic EPF. No comprehensive information on the efficacie... περισσότερα »
Sensitive detection of mercury in saliva
Oligonucleotide-functionalized carbon nanotubes chemiresistor for sensitive detection of mercury in saliva: [image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00018E, Paper Dawit N Wordofa, Pankaj Ramnani, Thien Toan Tran, Ashok Mulchandani Divalent mercuric (Hg2+) ion and monomethyl mercury (CH3Hg+) are two forms of mercury that are known to be highly toxic to humans. In this work, we present a highly selective,... The content of this RSS Feed (c) The Royal Society of Chemistry
The ThinPrep Imaging System (TIS) is an accurate time-saving method of reading cervical ThinPrep slides in screening programs
Is there a role for the thinprep imaging system in reporting anal cytology?: Background The ThinPrep Imaging System (TIS) is an accurate time-saving method of reading cervical ThinPrep slides in screening programs. As anal and cervical cytology are morphologically similar, TIS can potentially be used for anal cytology. We assessed the performance of TIS on anal ThinPrep slides from homosexual men in a natural history study of human papillomavirus-related anal abnormalities. Methods Four hundred nineteen anal cytology slides were processed by TIS and classified by a cytologist as ei...περισσότερα »
Uveal melanoma
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status: Background Choroidal and ciliary body melanomas divide into two approximately equal groups. Local therapy cures one group while the other metastasizes and proves lethal. Monosomy 3 strongly associates with aggressive behavior. We analyzed a series of choroidal and ciliary body melanomas to describe the cellular features and to compare them to monosomy 3 status using the latter as a surrogate for survival. Methods One hundred eleven specimens met the study's inclusion criteria. Following ThinPrep p...περισσότερα »
Hidradenocarcinoma presenting as soft tissue mass
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis: Hidradenocarcinoma (HAC) is a rare adenexal tumor with a propensity for the head and neck region and extremities. We report a case of hidradenocarcinnoma in a 56-year-old woman with a mass on her right palm sampled by fine-needle aspiration and later confirmed on histological examination. Fine-needle aspiration cytology revealed a dual population of cells including polyhedral eosinophilic cells and glycogen containing cells with pale/... περισσότερα »
Cervical nodal metastases from head and neck squamous cell carcinoma: MRI criteria for treatment assessment
Cervical nodal metastases from head and neck squamous cell carcinoma: MRI criteria for treatment assessment: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to assess MRI criteria for detecting residual malignant head and neck squamous cell carcinoma (HNSCC) nodes after chemoradiotherapy (CRT). Methods One hundred and six metastatic nodes were assessed 6 weeks posttreatment by MRI for necrosis, extranodal neoplastic spread (ENS), size, and percentage of size change. Size measurements were reanalyzed after dividing posttreatment...περισσότερα »
Endoscopic endonasal study of the cavernous sinus and quadrangular space: Anatomic relationships
Endoscopic endonasal study of the cavernous sinus and quadrangular space: Anatomic relationships: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The quadrangular space permits an anterior entry into Meckel's cave while obviating the need for cerebral or cranial nerve retraction. This avenue is intimately associated with the cavernous sinus; thus, from this ventral perspective, it is feasible to visualize the anteromedial, anterolateral, and Parkinson triangles. Methods Twenty middle cranial fossae were dissected endonasally under direct endoscopic visualiz... περισσότερα »
Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era
Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era: Abstract Background The purpose of this study was to prospectively evaluate the scintigraphic results on patients who undergo intensity-modulated radiotherapy (IMRT) to investigate the tolerance doses for the salivary glands. Methods Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy (RT), and then at 6 weeks and again at 3 months after the comple... περισσότερα »
Multiple endocrine neoplasia type 2 kindred with novel tandem RET mutations: Case report with an applied in silico mutational tolerance analysis
Multiple endocrine neoplasia type 2 kindred with novel tandem RET mutations: Case report with an applied in silico mutational tolerance analysis: Abstract Background The American Thyroid Association (ATA) has established guidelines for prophylactic thyroidectomy in multiple endocrine neoplasia type 2A (MEN2A) based on rearranged during transfection (*RET*) mutations. In silico analysis, which uses computer modeling to predict alterations in protein structure, is a new method for studying these mutations. Methods We describe a kindred with MEN2A, all sharing a well-documented *RET* ...περισσότερα »
Exercise therapy for trismus secondary to head and neck cancer: A systematic review
Exercise therapy for trismus secondary to head and neck cancer: A systematic review: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. Methods Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Results Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching techniques, duration of stretch, and repetition of exerci...περισσότερα »
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (*FAT1*) and determine the prognostic significance of *FAT1* mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer ...περισσότερα »
Validation of methodology for assessment of pulmonary function in patients who undergo total laryngectomy
Validation of methodology for assessment of pulmonary function in patients who undergo total laryngectomy: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] ABSTRACT Background In patients submitted to laryngectomy, pulmonary complications may lead to death. A simple method with a standardized extratracheal device for the pulmonary assessment of laryngectomized patients would be very useful. The purpose of this study was to validate the methodology for pulmonary assessment in these patients through the application of an adhesive extratracheal device. Methods This transversal stu... περισσότερα »
Evolution of surgical techniques for mandibular reconstruction using free fibula flaps: The next generation
Evolution of surgical techniques for mandibular reconstruction using free fibula flaps: The next generation: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Virtual surgical planning (VSP) has contributed to a number of technical innovations in mandible reconstruction. We report on these innovations and the overall evolution of mandible reconstruction using free fibula flaps at our institution. Methods We performed a retrospective chart review of all patients who underwent virtually planned free fibula flap reconstruction of the mandible. Comparisons were m... περισσότερα »
Impact of preoperative embolization on the outcomes of carotid body tumor surgery: A meta-analysis and review of the literature
Impact of preoperative embolization on the outcomes of carotid body tumor surgery: A meta-analysis and review of the literature: Abstract Background There is no consensus on the impact of preoperative embolization (EMB) on the surgical outcomes of carotid body tumor (CBT) resections. Methods A systematic review and a meta-analysis were conducted to clarify the role of preoperative EMB in patients undergoing surgical removal of CBTs. Results Fifteen studies with a total number of 470 patients met the inclusion criteria. The results of the meta-analysis showed that there is no signific...περισσότερα »
Role of endoscopic surgery in the management of sinonasal and skull base schwannomas
Role of endoscopic surgery in the management of sinonasal and skull base schwannomas: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to report our experience with the endoscopic management of sinonasal schwannomas, analyzing the advantages, limitations, and outcomes of the technique. Methods A retrospective analysis was carried out on 11 patients treated endoscopically between 2000 and 2014 at a single institution. Results Eight patients underwent an exclusive endoscopic endonasal approach, whereas, in 3 patients, an osteoplast... περισσότερα »
Pustular prurigo pigmentosa treated with doxycycline
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Successful treatment of primary cutaneous Nocardia brasiliensis infection with oral potassium iodide
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Eosinophilic pustular folliculitis: Trends in therapeutic options
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Oral tofacitinib efficacy, safety and tolerability in Japanese patients with moderate to severe plaque psoriasis and psoriatic arthritis: A randomized, double-blind, phase 3 study
Abstract Tofacitinib is an oral Janus kinase inhibitor that is being investigated for psoriasis and psoriatic arthritis. Japanese patients aged 20 years or more with moderate to severe plaque psoriasis and/or psoriatic arthritis were double-blindly randomized 1:1 to tofacitinib 5 or 10 mg b.i.d. for 16 weeks, open-label 10 mg b.i.d. for 4 weeks, then variable 5 or 10 mg b.i.d. to Week 52. Primary end-points at Week 16 were the proportion of patients achieving at least a 75% reduction in Psoriasis Area and Severity Index (PASI75) and Physician's Global Assessment of "clear" or "almo... περισσότερα »
Association of anti-RNA polymerase III antibody and silicone breast implants in patients with systemic sclerosis
Abstract Systemic sclerosis (SSc) is believed to be caused by a complex interplay between genetic factors and environmental influences. Although silicone has been considered to be a candidate of environmental agents, clinical data presented so far fail to show a significant association between silicone breast implant (SBI) and the development of SSc. Because we recently experienced two consecutive SSc patients with anti-RNA polymerase III (RNAP III) antibody who underwent SBI, we here investigated the association of SBI history with the development of SSc positive for anti-RNAP III...περισσότερα »
Extensive tumoral melanosis associated with ipilimumab-treated melanoma
Abstract Tumoral melanosis describes a pigmented lesion clinically similar to melanoma but that histologically reveals dense aggregates of melanin-laden, benign macrophages without malignant cells. In the few reported cases, tumoral melanosis has arisen in the skin or lymph node of a patient with a regressed melanoma or an epithelioid tumor. As a marker of regressed primary melanoma, its discovery may prompt investigation and surveillance for undiagnosed local or metastatic disease. Here, we present a unique case of extensive tumoral melanosis arising during ipilimumab treatment of...περισσότερα »
Macromol. Rapid Commun. 4/2016
[image: Thumbnail image of graphical abstract] *Front Cover:* Electron-donating alkylthio and alkoxy side chains often show unique properties that can tune the electronic character of conjugated polymer donor materials in organic solar cell applications. In this review, such rational electron-donating side chain engineering in improving the photovoltaic properties of the resulting polymer donors is surveyed and discussed. Further details can be found in the article by C. Cui,* and W.-Y. Wong* on page 287. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1Vgl... περισσότερα »
Contents: Macromol. Rapid Commun. 4/2016
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Macromol. Rapid Commun. 4/2016
[image: Thumbnail image of graphical abstract] *Back Cover:* Potential uses in full-color displays and back-lighting units for liquid crystal displays are described. We fabricated white-light-emitting, electrospun PEO sheets containing a hyperbranched conjugated polymer (HBP), which has the unique property of exhibiting a variety of fluorescence colors, leading to easy manipulation of the emission colors of the PEO sheets by simple variation of the HBP concentrations in the PEO. Further details can be found in the article by J. Kim, and T. S. Lee* on page 303. from Biomedical Eng... περισσότερα »
Masthead: Macromol. Rapid Commun. 4/2016
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The clinical characteristics of primary gastric lymphoma detected during screening for gastric cancer in Korea
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
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Effectiveness of anise oil for treatment of mild to moderate depression in patients with irritable bowel syndrome: a randomized active and placebo-controlled clinical trial
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
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Follow-up study on CDX1 and CDX2 mRNA expression in noncancerous gastric mucosae after Helicobacter pylori eradication
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
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Surgical aspects of inflammatory bowel diseases in pediatric and adolescent age groups
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
International Journal of Colorectal Disease from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1VgqA2X via IFTTT
SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
Tumor Biology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1VgqCrE via IFTTT
Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
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Laparoscopic cholecystectomy during pregnancy: A systematic review
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 35 δευτερόλεπτα
International Journal of Surgery from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/20yIfnU via IFTTT
Severe Hyperacusis, Photophobia, and Skin Hypersensitivity
*Severe Hyperacusis, Photophobia, and Skin Hypersensitivity: We report a case of a patient with severe hyperacusis, photophobia, and skin hypersensitivity. The patient was initially treated with sound therapy and medical therapy for 4 months and successfully with a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy which improved her mood and the tolerance for sounds and light. * 1. Introduction *Hyperacusis is defined as “unusual tolerance to ordinary environmental sounds” [1] or as “consistently exaggerated or inappropriate responses to sounds that a...περισσότερα »
Subglottic granulation
Main ArticleA murine model of subglottic granulationA Ghosha1 c1, K P Leahy a1, S Singhala2, E Einhorna3, P Howletta3, N A Cohena1 and N Mirzaa1 a1 Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia a2 Department of Thoracic Surgery, University of Pennsylvania, Philadelphia a3 Department of Pathology, Philadelphia Veterans’ Affairs Medical Center, Pennsylvania, USA Abstract Objective: This study aimed to develop a functional model of subglottic stenosis by inducing direct airway irritation in transplanted mouse laryngotracheal complexes. M... περισσότερα »
Validation of methodology for assessment of pulmonary function in patients who undergo total laryngectomy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
ABSTRACT Background In patients submitted to laryngectomy, pulmonary complications may lead to death. A simple method with a standardized extratracheal device for the pulmonary assessment of laryngectomized patients would be very useful. The purpose of this study was to validate the methodology for pulmonary assessment in these patients through the application of an adhesive extratracheal […]
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Abstract Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International […]
Exercise therapy for trismus secondary to head and neck cancer: A systematic review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Abstract Background Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. Methods Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Results Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching […]
Multiple endocrine neoplasia type 2 kindred with novel tandem RET mutations: Case report with an applied in silico mutational tolerance analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Abstract Background The American Thyroid Association (ATA) has established guidelines for prophylactic thyroidectomy in multiple endocrine neoplasia type 2A (MEN2A) based on rearranged during transfection (RET) mutations. In silico analysis, which uses computer modeling to predict alterations in protein structure, is a new method for studying these mutations. Methods We describe a kindred with MEN2A, […]
Cancers, Vol. 8, Pages 22: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic […]
PulmCrit- BRASH syndrome: Bradycardia, Renal failure, Av blocker, Shock, Hyperkalemia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
This is one of my favorite diagnoses. When first encountered, it may seem bewildering and difficult to treat (1). Indeed, standard ACLS algorithms often fail with these patients. However, once understood, this disorder is easily treated and patients typically improve rapidly. EMCrit by Josh Farkas. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RFs1Jl via IFTTT
Utility of folate receptor alpha immunohistochemistry in cytology specimens of metastatic breast carcinoma, metastatic serous carcinoma of Müllerian origin, and primary lung adenocarcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Background Folate receptor alpha (FRA) overexpression by immunohistochemistry (IHC) has been shown to various degrees in histologic specimens from breast ductal carcinoma (DC), serous carcinoma of Müllerian origin (SCM), and primary lung adenocarcinoma (ADC) among others. Antifolate therapies have recently shown usefulness in FRA overexpressing malignancies. We assessed the feasibility for detecting FRA overexpression by […]
Synovial sarcoma presenting as a lung mass and diagnosed by cytology
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Synovial sarcoma is a common soft tissue sarcoma with variable fibrous and epithelial differentiation that rarely arises from other body sites, such as within the lung. A case of a 68-year-old male with an extensive smoking history who presented with chest pain and a primary, central, metabolically active lung mass was reported. The mass was […]
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Hidradenocarcinoma (HAC) is a rare adenexal tumor with a propensity for the head and neck region and extremities. We report a case of hidradenocarcinnoma in a 56-year-old woman with a mass on her right palm sampled by fine-needle aspiration and later confirmed on histological examination. Fine-needle aspiration cytology revealed a dual population of cells including […]
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα
Background Choroidal and ciliary body melanomas divide into two approximately equal groups. Local therapy cures one group while the other metastasizes and proves lethal. Monosomy 3 strongly associates with aggressive behavior. We analyzed a series of choroidal and ciliary body melanomas to describe the cellular features and to compare them to monosomy 3 status using […]
Merkel cell carcinoma of the head and neck
Main ArticleMerkel cell carcinoma of the head and neck: poorer prognosis than non-head and neck sitesG B Moranda1, J Madanaa1, S D Da Silvaa1, M P Hiera1, A M Mlynareka1 and M J Blacka1 c1 a1 Department of Otolaryngology – Head and Neck Surgery, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montréal, Québec, Canada Abstract Background: Merkel cell carcinoma is a rare, aggressive neurocutaneous malignancy. This study investigated whether patients with Merkel cell carcinoma in the head and neck had poorer outcomes than patients with Merkel cell carcinoma located elsew... περισσότερα »
Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Predictors of post-treatment smoking and drinking behavior of head and neck cancer survivors: results of a population-based survey. Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Schiller U, Inhestern J, Burger U, Singer S, Guntinas-Lichius O Abstract Predictors for smoking and alcohol drinking behavior were investigated in head and neck cancer survivors (HNCS) with […]
Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Effectiveness of superselective intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis. Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S Abstract We sought to evaluate the efficacy and […]
Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Skp2 Regulates the Expression of MMP-2 and MMP-9, and Enhances the Invasion Potential of Oral Squamous Cell Carcinoma. Pathol Oncol Res. 2016 Feb 13; Authors: Yamada SI, Yanamoto S, Naruse T, Matsushita Y, Takahashi H, Umeda M, Nemoto TK, Kurita H Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor […]
Nodal yield of neck dissections and influence on outcome in laryngectomized patients.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Nodal yield of neck dissections and influence on outcome in laryngectomized patients. Eur Arch Otorhinolaryngol. 2016 Feb 13; Authors: Böttcher A, Dommerich S, Sander S, Olze H, Stromberger C, Coordes A, Jowett N, Knopke S Abstract The appropriate extent of neck dissection (ND) in head and neck squamous cell carcinoma (SCC) continues to […]
Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3. Allergol Int. 2016 Feb 10; Authors: Saito H, Honda K, Asaka C, Ueki S, Ishikawa K Abstract BACKGROUND: The chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved […]
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy. Oral Oncol. 2016 Feb 10; Authors: Kraaijenga SA, Oskam IM, van Son RJ, Hamming-Vrieze O, Hilgers FJ, van den Brekel MW, van der Molen L Abstract OBJECTIVES: Assessment of long-term objective and subjective voice, […]
Patient derived xenografts as tools in pharmaceutical development.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Related Articles Patient derived xenografts as tools in pharmaceutical development. Clin Pharmacol Ther. 2016 Feb 13; Authors: Izumchenko E, Meir J, Bedi A, Wysocki PT, Hoque M, Sidransky D Abstract Successful drug development in Oncology is grossly suboptimal, manifested by the very low percentage of new agents being developed that ultimately succeed in clinical approval. […]
Diseases, Vol. 4, Pages 10: Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Cancer immunotherapy using a patient’s own T cells redirected to recognize and kill tumor cells has achieved promising results in metastatic melanoma and leukemia. This technique involves harnessing a patient’s T cells and then delivering a gene that encodes a new T cell receptor (TCR) or a chimeric antigen receptor (CAR) that allow the cells […]
Merkel cell carcinoma of the head and neck: poorer prognosis than non-head and neck sites
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Research Articles G B Morand, J Madana, S D Da Silva, M P Hier, A M Mlynarek, M J Black The Journal of Laryngology & Otology,FirstView Article(s), 5 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U34C53 via IFTTT
Serum sTREM-1 level is quite higher in Crimean Congo Hemorrhagic Fever, a viral infection
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Abstract Background Members of triggering receptor expressed on myeloid cells (TREM) family are known as immunmodulators in several infectious or noninfectious inflammatory disorders. The information about their role in viral infections is very limited. To enlighten if there’s a relation between soluble TREM-1(sTREM-1) and a viral infection, Crimean Congo Haemorrhagic Fever (CCHF). Methods We investigated […]
Imbalance of Gastrointestinal Microbiota in the Pathogenesis of Helicobacter pylori-Associated Diseases
Imbalance of Gastrointestinal Microbiota in the Pathogenesis of Helicobacter pylori-Associated Diseases: Abstract The development of new nucleotide sequencing techniques and advanced bioinformatics tools has opened the field for studying the diversity and complexity of the gastrointestinal microbiome independent of traditional cultural methods. Owing largely to the gastric acid barrier, the human stomach was long thought to be sterile. The discovery of *Helicobacter pylori*, the gram-negative bacterium that infects upwards of 50% of the global population, has started a major paradi... περισσότερα »
Assessment of conjunctival microvilli abnormality by micro-Raman analysis – by G. Rusciano et al
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Conjunctival microvilli are microscopic cellular membrane protrusions on apical epithelial cells, which increase the surface area available for tear adherence. Pathological alterations of microvilli structure affect the tear film stability and, conversely, dysfunctions of tear film composition can lead to a suffering epithelium (dry-eye syndrome). In this work we propose the use of micro-Raman analysis […]
Atmosphere, Vol. 7, Pages 27: Surface Ozone Concentration and Its Relationship with UV Radiation, Meteorological Parameters and Radon on the Eastern Coast of the Baltic Sea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Hourly and daily variations of ground-level ozone have been analyzed in relation to meteorological parameters, UVB radiation and radon near the Baltic Sea in Lithuania. An atypical situation with respect to wind domination was observed during the experiment: the wind from the continent was twice as frequent as the wind from the sea. The close […]
Effect of bisphenol A on morphology, apoptosis and proliferation in the resting mammary gland of the adult albino rat
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Bisphenol A (BPA) is a synthetic oestrogen that is extensively used in a wide range of daily used plastic products. This makes it one of the environmental chemicals that may have impact on human health. Due to its oestrogenic effect, BPA might affect the mammary gland. This study aimed to investigate the influence of […]
Synovial sarcoma presenting as a lung mass and diagnosed by cytology
Synovial sarcoma is a common soft tissue sarcoma with variable fibrous and epithelial differentiation that rarely arises from other body sites, such as within the lung. A case of a 68-year-old male with an extensive smoking history who presented with chest pain and a primary, central, metabolically active lung mass was reported. The mass was biopsied by bronchial brushing, bronchoalveolar lavage (BAL), and transbronchial fine-needle aspiration (FNA). Cytologic analysis of bronchial brushing, BAL, and FNA revealed single and clusters of atypical spindle cells, oval, or spindle-shap... περισσότερα »
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis
Hidradenocarcinoma (HAC) is a rare adenexal tumor with a propensity for the head and neck region and extremities. We report a case of hidradenocarcinnoma in a 56-year-old woman with a mass on her right palm sampled by fine-needle aspiration and later confirmed on histological examination. Fine-needle aspiration cytology revealed a dual population of cells including polyhedral eosinophilic cells and glycogen containing cells with pale/clear cytoplasm. The nuclei were pleomorphic with prominent nucleoli. Occassional papillary structures were identified on the cell block material. A...περισσότερα »
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status
Background Choroidal and ciliary body melanomas divide into two approximately equal groups. Local therapy cures one group while the other metastasizes and proves lethal. Monosomy 3 strongly associates with aggressive behavior. We analyzed a series of choroidal and ciliary body melanomas to describe the cellular features and to compare them to monosomy 3 status using the latter as a surrogate for survival. Methods One hundred eleven specimens met the study's inclusion criteria. Following ThinPrep processing, samples were analyzed for cellular features including: cell type, nuclea...περισσότερα »
Is there a role for the thinprep imaging system in reporting anal cytology?
Background The ThinPrep Imaging System (TIS) is an accurate time-saving method of reading cervical ThinPrep slides in screening programs. As anal and cervical cytology are morphologically similar, TIS can potentially be used for anal cytology. We assessed the performance of TIS on anal ThinPrep slides from homosexual men in a natural history study of human papillomavirus-related anal abnormalities. Methods Four hundred nineteen anal cytology slides were processed by TIS and classified by a cytologist as either *No further review* (slide archived) or *Manual review* (slide requir... περισσότερα »
Prognostic factors in children with PRES and hematologic diseases
Objectives Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity characterized by focal neurological signs, headache, confusion, and seizure, associated with transitory lesions in the posterior areas of the brain detectable with neuroimaging. Among children, one of the most common causes of PRES is cancer. Materials and Methods In this review, we present the cases of 5 children developing PRES after stem cell transplantation for hematological disease and review all the cases reported in English literature to investigate outcomes and associated ... περισσότερα »
Annals of Neurology: Volume 79, Number 2, February 2016
from Neurology via xlomafota13 on Inoreader http://ift.tt/1QgE8NI via IFTTT
Nanomaterials, Vol. 6, Pages 32: Energy Transfer between Conjugated Colloidal Ga2O3 and CdSe/CdS Core/Shell Nanocrystals for White Light Emitting Applications
Developing solid state materials capable of generating homogeneous white light in an energy efficient and resource-sustainable way is central to the design of new and improved devices for various lighting applications. Most currently-used phosphors depend on strategically important rare earth elements, and rely on a multicomponent approach, which produces sub-optimal quality white light. Here, we report the design and preparation of a colloidal white-light emitting nanocrystal conjugate. This conjugate is obtained by linking colloidal Ga2O3 and II–VI nanocrystals in the solution p... περισσότερα »
Micromachines, Vol. 7, Pages 30: CMOS-NEMS Copper Switches Monolithically Integrated Using a 65 nm CMOS Technology
This work demonstrates the feasibility to obtain copper nanoelectromechanical (NEMS) relays using a commercial complementary metal oxide semiconductor (CMOS) technology (ST 65 nm) following an intra CMOS-MEMS approach. We report experimental demonstration of contact-mode nano-electromechanical switches obtaining low operating voltage (5.5 V), good ION/IOFF (103) ratio, abrupt subthreshold swing (4.3 mV/decade) and minimum dimensions (3.50 μm × 100 nm × 180 nm, and gap of 100 nm). With these dimensions, the operable Cell area of the switch will be 3.5 μm (length) × 0.2 μm (100 nm w... περισσότερα »
JMSE, Vol. 4, Pages 10: Bias and Efficiency Tradeoffs in the Selection of Storm Suites Used to Estimate Flood Risk
Modern joint probability methods for estimating storm surge or flood statistics are based on statistical aggregation of many hydrodynamic simulations that can be computationally expensive. Flood risk assessments that consider changing future conditions due to sea level rise or other drivers often require each storm to be run under a range of uncertain scenarios. Evaluating different flood risk mitigation measures, such as levees and floodwalls, in these future scenarios can further increase the computational cost. This study uses the Coastal Louisiana Risk Assessment model (CLARA)... περισσότερα »
Information, Vol. 7, Pages 7: An Approach to the Classification of Cutting Vibration on Machine Tools
Predictions of cutting vibrations are necessary for improving the operational efficiency, product quality, and safety in the machining process, since the vibration is the main factor for resulting in machine faults. "Cutting vibration" may be caused by setting incorrect parameters before machining is commenced and may affect the precision of the machined work piece. This raises the need to have an effective model that can be used to predict cutting vibrations. In this study, an artificial neural network (ANN) model to forecast and classify the cutting vibration of the intelligent ... περισσότερα »
Cancers, Vol. 8, Pages 22: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic response have all been shown to be impacted by the Shh signaling pathway. Downstream effectors of the Shh pathway include smoothened (SMO) and glioma-associated oncogene homolog (GLI) fa...περισσότερα »
JCM, Vol. 5, Pages 25: Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype
Dietary inclusion of fish and fish supplements as a means to improve cancer prognosis and prevent tumour growth is largely controversial. Long chain omega-3 polyunsaturated fatty acids (LCn-3 PUFA), eicosapentaenoic acid and docosahexaenoic acid, may modulate the production of inflammatory eicosanoids, thereby influencing local inflammatory status, which is important in cancer development. Although in vitro studies have demonstrated inhibition of tumour cell growth and proliferation by LCn-3 PUFA, results from human studies have been mainly inconsistent. Genes involved in the desa...περισσότερα »
Biomedicines, Vol. 4, Pages 5: In Vivo Efficacy of Artesunate/Sulphadoxine-Pyrimethamine versus Artesunate/Amodiaquine in the Treatment of Uncomplicated P. falciparium Malaria in Children around the Slope of Mount Cameroon: A Randomized Controlled Trial
Background: The development and spread of antimalarial drug resistant parasites contributes to the global impact of the disease. In vivo efficacy assessments of treatments for Plasmodium falciparum malaria are essential for ensuring effective case management. Artemisinin-based combinations have been adopted as the first-line treatment for uncomplicated P. falciparum malaria in Cameroon since 2004. Methods: A total of 177 children aged six-months to 10 years with uncomplicated mono-infected falciparum malaria were randomized (1:1) to receive artesunate/sulphadoxine-pyrimethamine (A... περισσότερα »
Challenges, Vol. 7, Pages 3: Practical Eco-Design and Eco-Innovation of Consumer Electronics—the Case of Mobile Phones
Annually, it is estimated that about 4 billion units of consumer electronics for mobile communications are produced worldwide. This could lead to various ecological imbalances unless the design and disposal of the products are handled optimally. To illustrate how industry looks at and responds to the increasing social awareness, this article describes how sustainability is successfully implemented in practice at a large Chinese company, developing and producing various kinds of electronic products used for communication. It also describes how a variety of eco-innovations and busin... περισσότερα »
Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
BACKGROUND: We previously reported improved neurodevelopmental outcomes at 2 years among infants treated with the erythropoiesis-stimulating agents (ESAs) darbepoetin alfa (darbepoetin) or erythropoietin. Here we characterize 4-year outcomes. METHODS: Former preterm infants randomly assigned to receive darbepoetin (10 μg/kg, once per week), erythropoietin (400 U/kg, 3 times/week), or placebo through 35 weeks’ postconceptual age were […]
Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group «A» have been found to be highly susceptible to falciparum malaria whereas blood group […]
IJMS, Vol. 17, Pages 236: miR-9-5p, miR-675-5p and miR-138-5p Damages the Strontium and LRP5-Mediated Skeletal Cell Proliferation, Differentiation, and Adhesion
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
This study was designed to evaluate the effects of strontium on the expression levels of microRNAs (miRNAs) and to explore their effects on skeletal cell proliferation, differentiation, adhesion, and apoptosis. The targets of these miRNAs were also studied. Molecular cloning, cell proliferation assay, cell apoptosis assay, quantitative real-time PCR, and luciferase reporter assay were used. […]
Successful treatment of pachydermoperiostosis with etoricoxib in a patient with a homozygous splice-site mutation in the SLCO2A1 gene
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Pachydermoperiostosis (PDP), also named primary hypertrophic osteoarthropathy (PHO: MIM 167100), is a rare genetic disease characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and digital clubbing. Additional clinical signs and symptoms include seborrheic hyperplasia, hyperhidrosis, and arthropathy. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on […]
Postepy Hig Med Dosw 2016; 70:86-94 «Carcinogenic viruses in etiopathogenesis of skin cancers in patients after organ transplantation»
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus – HPV, Human herpesvirus 8 – HHV8 i Merkel cell polyomavirus – MCV. Report on connections exisisting between viruses […]
Postepy Hig Med Dosw 2016; 70:86-94 «Carcinogenic viruses in etiopathogenesis of skin cancers in patients after organ transplantation»
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus – HPV, Human herpesvirus 8 – HHV8 i Merkel cell polyomavirus – MCV. Report on connections exisisting between viruses […]
Molecules, Vol. 21, Pages 212: Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
A series of novel 13- to 15-member hydroxyproline-based macrocycles, which contain alkyl-alkyl ether and alkyl-aryl ether moieties, have been synthesized by the strategy of macrocyclization utilising azide-alkyne cycloaddition, Mitsunobu protocol and amide formation. Their anti-tumor activities towards A549, MDA-MB-231 and Hep G2 cells were screened in vitro by an MTT assay. The results indicated that […]
Validation of methodology for assessment of pulmonary function in patients who undergo total laryngectomy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Background In patients submitted to laryngectomy, pulmonary complications may lead to death. A simple method with a standardized extratracheal device for the pulmonary assessment of laryngectomized patients would be very useful. The purpose of this study was to validate the methodology for pulmonary assessment in these patients through the application of an adhesive extratracheal […]
Annals of Neurology: Volume 79, Number 2, February 2016
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QgE8NI via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VgjrzK via IFTTT
‘Thousands of UK cancer patients are spending their final hours in pain’ says new report from @macmi llancancer https://t.co/EsEEre4J5h
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
‘Thousands of UK cancer patients are spending their final hours in pain’ says new report from @macmillancancer https://t.co/EsEEre4J5h from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/699152936178421760 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XsIy3N via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KRdadb via IFTTT
Utility of folate receptor alpha immunohistochemistry in cytology specimens of metastatic breast carcinoma, metastatic serous carcinoma of Müllerian origin, and primary lung adenocarcinoma
Background Folate receptor alpha (FRA) overexpression by immunohistochemistry (IHC) has been shown to various degrees in histologic specimens from breast ductal carcinoma (DC), serous carcinoma of Müllerian origin (SCM), and primary lung adenocarcinoma (ADC) among others. Antifolate therapies have recently shown usefulness in FRA overexpressing malignancies. We assessed the feasibility for detecting FRA overexpression by IHC in cytologic cell blocks (CB) from the aforementioned carcinomas. Method Cases of breast DC, SCM and lung ADC were included. The CB were immunostained with ... περισσότερα »
Synovial sarcoma presenting as a lung mass and diagnosed by cytology
Synovial sarcoma is a common soft tissue sarcoma with variable fibrous and epithelial differentiation that rarely arises from other body sites, such as within the lung. A case of a 68-year-old male with an extensive smoking history who presented with chest pain and a primary, central, metabolically active lung mass was reported. The mass was biopsied by bronchial brushing, bronchoalveolar lavage (BAL), and transbronchial fine-needle aspiration (FNA). Cytologic analysis of bronchial brushing, BAL, and FNA revealed single and clusters of atypical spindle cells, oval, or spindle-shap... περισσότερα »
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis
Hidradenocarcinoma (HAC) is a rare adenexal tumor with a propensity for the head and neck region and extremities. We report a case of hidradenocarcinnoma in a 56-year-old woman with a mass on her right palm sampled by fine-needle aspiration and later confirmed on histological examination. Fine-needle aspiration cytology revealed a dual population of cells including polyhedral eosinophilic cells and glycogen containing cells with pale/clear cytoplasm. The nuclei were pleomorphic with prominent nucleoli. Occassional papillary structures were identified on the cell block material. A...περισσότερα »
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status
Background Choroidal and ciliary body melanomas divide into two approximately equal groups. Local therapy cures one group while the other metastasizes and proves lethal. Monosomy 3 strongly associates with aggressive behavior. We analyzed a series of choroidal and ciliary body melanomas to describe the cellular features and to compare them to monosomy 3 status using the latter as a surrogate for survival. Methods One hundred eleven specimens met the study's inclusion criteria. Following ThinPrep processing, samples were analyzed for cellular features including: cell type, nuclea...περισσότερα »
Is there a role for the thinprep imaging system in reporting anal cytology?
Background The ThinPrep Imaging System (TIS) is an accurate time-saving method of reading cervical ThinPrep slides in screening programs. As anal and cervical cytology are morphologically similar, TIS can potentially be used for anal cytology. We assessed the performance of TIS on anal ThinPrep slides from homosexual men in a natural history study of human papillomavirus-related anal abnormalities. Methods Four hundred nineteen anal cytology slides were processed by TIS and classified by a cytologist as either *No further review* (slide archived) or *Manual review* (slide requir... περισσότερα »
A review of the proposed role of neutrophils in rodent amebic liver abscess models
Authors: Rafael Campos-Rodríguez, Manuel Gutiérrez-Meza, Rosa Adriana Jarillo-Luna, María Elisa Drago-Serrano, Edgar Abarca-Rojano, Javier Ventura-Juárez, Luz María Cárdenas-Jaramillo and Judith Pacheco-Yepez.<br>Parasite Vol. 23 , page 6<br>Published online: 15/02/2016<br> Keywords: Amoebic liver abscess ; Rodents ; Neutrophil activation ; Reactive oxygen and nitrogen species ; Peroxynitrite ; Neutrophil extracellular traps.<img src="http://ift.tt/1LppGvA" height="1" width="1" alt=""> from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oiKikg via IFTTT
Prognostic factors in children with PRES and hematologic diseases
Objectives Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological entity characterized by focal neurological signs, headache, confusion, and seizure, associated with transitory lesions in the posterior areas of the brain detectable with neuroimaging. Among children, one of the most common causes of PRES is cancer. Materials and Methods In this review, we present the cases of 5 children developing PRES after stem cell transplantation for hematological disease and review all the cases reported in English literature to investigate outcomes and associated ... περισσότερα »
Annals of Neurology: Volume 79, Number 2, February 2016
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1QgE8NI via IFTTT
Severe Hyperacusis, Photophobia, and Skin Hypersensitivity
We report a case of a patient with severe hyperacusis, photophobia, and skin hypersensitivity. The patient was initially treated with sound therapy and medical therapy for 4 months and successfully with a selective serotonin reuptake inhibitor (SSRI) and cognitive behavioral therapy which improved her mood and the tolerance for sounds and light. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1R41i73 via IFTTT
Is proprioception diminished in patients with patellar tendinopathy?
Publication date: Available online 15 February 2016 *Source:*Gait & Posture Author(s): H.E. Groot, H. van der Worp, L. Nijenbanning, R.L. Diercks, J. Zwerver, I. van den Akker-Scheek PurposePatellar tendinopathy is a highly prevalent overuse injury, and most treatments are only effective to some extent. This persistence of complaints could be linked to changed proprioception. One study showed diminished proprioception in athletes with lateral epicondylitis. Aim of this study was to determine differences in proprioception, by measuring threshold to detect passive motion (TTDPM) betwe... περισσότερα »
Effect of bisphenol A on morphology, apoptosis and proliferation in the resting mammary gland of the adult albino rat
Summary Bisphenol A (BPA) is a synthetic oestrogen that is extensively used in a wide range of daily used plastic products. This makes it one of the environmental chemicals that may have impact on human health. Due to its oestrogenic effect, BPA might affect the mammary gland. This study aimed to investigate the influence of BPA on the histological structure of the mammary gland of the adult female albino rat and its effect on epithelial cell proliferation and apoptosis status, in addition to its possible modulating effect on estrogen receptor expression. Thirty female adult albin... περισσότερα »
Biological verification of sterilization cycles in dental clinics in Mexico
Publication date: Available online 15 February 2016 *Source:*American Journal of Infection Control Author(s): Berenice Galeote-Carmona, Leonor Sánchez-Pérez, A. Enrique Acosta-Gío from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/20VqrZw via IFTTT
Role of endoscopic surgery in the management of sinonasal and skull base schwannomas
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to report our experience with the endoscopic management of sinonasal schwannomas, analyzing the advantages, limitations, and outcomes of the technique. Methods A retrospective analysis was carried out on 11 patients treated endoscopically between 2000 and 2014 at a single institution. Results Eight patients underwent an exclusive endoscopic endonasal approach, whereas, in 3 patients, an osteoplastic flap was combined because of massive or lateral frontal sinus involvement. The t... περισσότερα »
Impact of preoperative embolization on the outcomes of carotid body tumor surgery: A meta-analysis and review of the literature
Abstract Background There is no consensus on the impact of preoperative embolization (EMB) on the surgical outcomes of carotid body tumor (CBT) resections. Methods A systematic review and a meta-analysis were conducted to clarify the role of preoperative EMB in patients undergoing surgical removal of CBTs. Results Fifteen studies with a total number of 470 patients met the inclusion criteria. The results of the meta-analysis showed that there is no significant difference in estimated blood loss, operative time, length of hospital stay, or risks of cranial nerve injury, vascular ... περισσότερα »
Evolution of surgical techniques for mandibular reconstruction using free fibula flaps: The next generation
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Virtual surgical planning (VSP) has contributed to a number of technical innovations in mandible reconstruction. We report on these innovations and the overall evolution of mandible reconstruction using free fibula flaps at our institution. Methods We performed a retrospective chart review of all patients who underwent virtually planned free fibula flap reconstruction of the mandible. Comparisons were made between cohorts based on distinct eras related to the virtual planning approach. Results Seventy-six p... περισσότερα »
Validation of methodology for assessment of pulmonary function in patients who undergo total laryngectomy
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] ABSTRACT Background In patients submitted to laryngectomy, pulmonary complications may lead to death. A simple method with a standardized extratracheal device for the pulmonary assessment of laryngectomized patients would be very useful. The purpose of this study was to validate the methodology for pulmonary assessment in these patients through the application of an adhesive extratracheal device. Methods This transversal study included 50 patients who had been submitted to total laryngectomy. Pulmonary tests were used to charact... περισσότερα »
Association between FAT1 mutation and overall survival in patients with human papillomavirus–negative head and neck squamous cell carcinoma
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (*FAT1*) and determine the prognostic significance of *FAT1* mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. *FAT1* mutational status was determined in 234 and 37 pati... περισσότερα »
Exercise therapy for trismus secondary to head and neck cancer: A systematic review
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. Methods Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. Results Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching techniques, duration of stretch, and repetition of exercises was found. The overall quality was moderate. Five of the 8 preventive studies ...περισσότερα »
Multiple endocrine neoplasia type 2 kindred with novel tandem RET mutations: Case report with an applied in silico mutational tolerance analysis
Abstract Background The American Thyroid Association (ATA) has established guidelines for prophylactic thyroidectomy in multiple endocrine neoplasia type 2A (MEN2A) based on rearranged during transfection (*RET*) mutations. In silico analysis, which uses computer modeling to predict alterations in protein structure, is a new method for studying these mutations. Methods We describe a kindred with MEN2A, all sharing a well-documented *RET* mutation, p.C634Y, as well as a mutation of undetermined significance, p.I852M, which we analyzed via in silico analysis. Results The p.C634Y ...περισσότερα »
Prospective investigation and literature review of tolerance dose on salivary glands using quantitative salivary gland scintigraphy in the intensity-modulated radiotherapy era
Abstract Background The purpose of this study was to prospectively evaluate the scintigraphic results on patients who undergo intensity-modulated radiotherapy (IMRT) to investigate the tolerance doses for the salivary glands. Methods Salivary scintigraphy was performed on 35 patients with head and neck cancer before the beginning of radiotherapy (RT), and then at 6 weeks and again at 3 months after the completion of RT. Xerostomia was recorded according to the Radiation Therapy and Oncology Group (RTOG) grade. Salivary function was evaluated by calculating the excretion rate chan... περισσότερα »
Is proprioception diminished in patients with patellar tendinopathy?
Publication date: Available online 15 February 2016 *Source:*Gait & Posture Author(s): H.E. Groot, H. van der Worp, L. Nijenbanning, R.L. Diercks, J. Zwerver, I. van den Akker-Scheek PurposePatellar tendinopathy is a highly prevalent overuse injury, and most treatments are only effective to some extent. This persistence of complaints could be linked to changed proprioception. One study showed diminished proprioception in athletes with lateral epicondylitis. Aim of this study was to determine differences in proprioception, by measuring threshold to detect passive motion (TTDPM) between... περισσότερα »
Is proprioception diminished in patients with patellar tendinopathy?
Publication date: Available online 15 February 2016 *Source:*Gait & Posture Author(s): H.E. Groot, H. van der Worp, L. Nijenbanning, R.L. Diercks, J. Zwerver, I. van den Akker-Scheek PurposePatellar tendinopathy is a highly prevalent overuse injury, and most treatments are only effective to some extent. This persistence of complaints could be linked to changed proprioception. One study showed diminished proprioception in athletes with lateral epicondylitis. Aim of this study was to determine differences in proprioception, by measuring threshold to detect passive motion (TTDPM) between... περισσότερα »
Is proprioception diminished in patients with patellar tendinopathy?
Publication date: Available online 15 February 2016 *Source:*Gait & Posture Author(s): H.E. Groot, H. van der Worp, L. Nijenbanning, R.L. Diercks, J. Zwerver, I. van den Akker-Scheek PurposePatellar tendinopathy is a highly prevalent overuse injury, and most treatments are only effective to some extent. This persistence of complaints could be linked to changed proprioception. One study showed diminished proprioception in athletes with lateral epicondylitis. Aim of this study was to determine differences in proprioception, by measuring threshold to detect passive motion (TTDPM) between... περισσότερα »
Antibiotics, Vol. 5, Pages 11: Treatment Modalities and Antimicrobial Stewardship Initiatives in the Management of Intra-Abdominal Infections
Antimicrobial stewardship programs (ASPs) focus on improving the utilization of broad spectrum antibiotics to decrease the incidence of multidrug-resistant Gram positive and Gram negative pathogens. Hospital admission for both medical and surgical intra-abdominal infections (IAIs) commonly results in the empiric use of broad spectrum antibiotics such as fluoroquinolones, beta-lactam beta-lactamase inhibitors, and carbapenems that can select for resistant organisms. This review will discuss the management of uncomplicated and complicated IAIs as well as highlight stewardship initia...περισσότερα »
Determining the Independent Risk Factors and Mortality Rate of Nosocomial Infections in Pediatric Patients
The objective of this study was to determine the rate, independent risk factors, and outcomes of healthcare-associated infections in pediatric patients. This study was performed between 2011 and 2014 in pediatric clinic and intensive care unit. 86 patients and 86 control subjects were included in the study. Of 86 patients with nosocomial infections (NIs), there were 100 NIs episodes and 90 culture growths. The median age was 32.0 months. The median duration of hospital stay of the patients was 30.0 days. The most frequent pathogens were Coagulase-negative Staphylococcus, Acinetoba... περισσότερα »
Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome
Aims. To detect anatomical and intrinsic histopathological features of the ascending aorta and left ventricular (LV) myocardium and evaluate right ventricular (RV) function in fetuses with hypoplastic left heart syndrome (HLHS). Methods. Twenty-five fetuses diagnosed with HLHS were followed up in the antenatal and postpartum periods. 12 necropsy heart specimens were analyzed for morphological and histological changes. Results. Prenatal echocardiography and pathologic anatomy displayed the typical characteristics of HLHS as a severe underdevelopment of the LV in the form of mitral ...περισσότερα »
Metals, Vol. 6, Pages 35: Microstructures and Mechanical Properties of Austempering SUS440 Steel Thin Plates
SUS440 is a high-carbon stainless steel, and its martensite matrix has high heat resistance, high corrosion resistance, and high pressure resistance. It has been widely used in mechanical parts and critical materials. However, the SUS440 martempered matrix has reliability problems in thin plate applications and thus research uses different austempering heat treatments (tempering temperature: 200 °C–400 °C) to obtain a matrix containing bainite, retained austenite, martensite, and the M7C3 phase to investigate the relationships between the resulting microstructure and tensile mecha... περισσότερα »
IJERPH, Vol. 13, Pages 220: Association between Polymorphisms and Haplotype in the ABCA1 Gene and Overweight/Obesity Patients in the Uyghur Population of China
Objective: This study aimed to detect the association between polymorphisms and haplotype in the ATP-binding cassette transporter A1 (ABCA1) gene and overweight/obese Uyghur patients in China. Methods: A total of 259 overweight/obese patients and 276 normal weight subjects, which were randomly selected from among 3049 adult Uyghurs, were matched for age. We genotyped ABCA1 single nucleotide polymorphisms of rs2515602, rs3890182, rs2275542, rs2230806, rs1800976, and rs4149313. Results: (1) The genotypic and allelic frequencies of rs2515602 and rs4149313 differed between the control... περισσότερα »
Diseases, Vol. 4, Pages 10: Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future
Cancer immunotherapy using a patient's own T cells redirected to recognize and kill tumor cells has achieved promising results in metastatic melanoma and leukemia. This technique involves harnessing a patient's T cells and then delivering a gene that encodes a new T cell receptor (TCR) or a chimeric antigen receptor (CAR) that allow the cells to recognize specific cancer antigens. The prospect of using engineered T cell therapy for persistent viral infections like hepatitis B virus (HBV) and their associated malignancies is promising. We recently tested in a first-in-man clinical ... περισσότερα »
CAV1 Prevents Gallbladder Cholesterol Crystallization by Regulating Biosynthesis and Transport of Bile Salts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Cholesterol gallstone disease (CGD) is a hepatobiliary disorder which results from a biochemical imbalance in the gallbladder bile. Here we show that loss of CAV1 sensitized mice to lithogenic diet-induced gallbladder cholesterol crystallization, which was associated with dysregulation of several hepatic transporters that efflux cholesterol, phospholipids, and bile salts. The combined effect of increased […]
Christus militans: Studien zur politisch-militärischen Semantik im Markusevangelium vor dem Hintergrund des ersten jüdisch-römischen Krieges
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
In Christus Militans knüpft Gabriella Gelardini an Interpretationen an, die das Markusevangelium im Kontext des jüdisch-römischen Krieges und des Aufstiegs der Flavier interpretieren. Von Interesse sind darin aber nicht nur „ideologische Macht- oder Herrschaftsdiskurse“ und damit „politische Theologie,“ sondern insbesondere auch die militärischen Zusammenhänge und die Kriegssemantik im engeren Sinn. Dies erfolgt eingedenk der großen […]
Rezension von: Cockerill, Gareth Lee. The Epistle to the Hebrews. The New International Commentary on the New Testament. Grand Rapids: Eerdmans, 2012
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R47RGL via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Annals of Neurology: Volume 79, Number 2, February 2016
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QgE8NI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Toxics, Vol. 4, Pages 5: Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS): A New Tool for the Analysis of Toxicological Effects on Single Cell Level
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Single cell imaging mass spectrometry opens up a complete new perspective for strategies in toxicological risk assessment and drug discovery. In particular, time-of-flight secondary ion mass spectrometry (ToF-SIMS) with its high spatial and depth resolution is becoming part of the imaging mass spectrometry toolbox used for single cell analysis. Recent instrumentation advancements in combination with […]
A murine model of subglottic granulation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Research Articles A Ghosh, K P Leahy, S Singhal, E Einhorn, P Howlett, N A Cohen, N Mirza The Journal of Laryngology & Otology,FirstView Article(s), 8 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ofRRaT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Viel Ballaststoffe in der Jugend – kein Brustkrebs im Alter?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Vorteile durch Früchte und Gemüse Wer schon frühzeitig auf eine ballaststoffreiche Ernährung setzt, reduziert möglicherweise das Risiko, an Brustkrebs zu erkranken. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VgbnPf via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
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