Early allergenic food introduction
Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen via Allergy and Clinical Immunology Publication date: Available online 17 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Michael R. Perkin, Kirsty Logan, Tom Marrs, Suzana Radulovic, Joanna Craven, Carsten Flohr, Gideon Lack BackgroundThe influence of early exposure to allergenic foods on the subsequent development of food allergy remains uncertain.ObjectiveWe sought to determine the feasibility of the early introduction of multiple allergenic foods to exclu...περισσότερα »
Laboratory animal allergy
Laboratory animal allergy: a new world.: Purpose of review: In recent years there has been a dramatic shift in the world of animal research whereby genetically modified mice have largely supplanted rats, and individually ventilated cages have been introduced to house delicate experimental animals in place of traditional open cages. Although laboratory animal allergy remains an important cause of occupational asthma, the risks associated with contemporary practice and consequently the opportunities for primary and secondary prevention are largely unknown. Recent findings: Although th... περισσότερα »
Self-esteem,Narcissism,Self-perceived Attractiveness
Interest in cosmetic surgery among Iranian women: the role of self-esteem, narcissism, and self-perceived attractiveness: Abstract BackgroundExamining psychological aspects of cosmetic surgery has gained considerable attention in the research literature, particularly among women. The present study aimed to examine the role of three self-worth variables including self-esteem, narcissism, and self-perceived attractiveness on interest in cosmetic surgery among Iranian women. MethodsThree hundred women were selected and completed a set of measures including Rosenberg Self-Esteem Sc...περισσότερα »
Propranolol Therapy for Problematic Infantile Hemangioma
Propranolol Therapy for Problematic Infantile Hemangioma: Background: Infantile hemangioma (IH) is a common, benign tumor occurring in up to 10% of white infants. Propranolol has emerged as a front-line therapy for IH. The retrospective study examined the response of propranolol therapy on hemangioma size. Methods: Twenty-seven children (4 to 20 weeks old) with IH were enrolled into the study of oral propranolol solution 2 mg/kg per day divided 3 times daily for 10 months. Response was assessed by size measurements at pretreatment and posttreatment. Scoring was stratified into no r...περισσότερα »
Secondary Genioplasties for the Treatment of Chin Deformities After Orthognathic Surgery in Asian Women: Defining the Aesthetic Importance of Managing the Chin Shape in Orthognathic Surgery
Secondary Genioplasties for the Treatment of Chin Deformities After Orthognathic Surgery in Asian Women: Defining the Aesthetic Importance of Managing the Chin Shape in Orthognathic Surgery: [image: image] Background: Achieving aesthetically favorable results in orthognathic surgery is equally as important as good postoperative occlusion and jaw function. Orthognathic surgery that only changes profile or proportion in the vertical dimension can often lead to patient’s dissatisfaction and additional surgical revision. To achieve maximal aesthetic improvement and postoperative patien...περισσότερα »
Which is the Ideal Breast Size?
Which is the Ideal Breast Size?: Some Social Clues for Plastic Surgeons: Abstract: To provide plastic surgeons with more detailed information as to factors affecting the perception of female attractiveness, the present study was aimed to investigate whether the interaction effect of breast and body size on ratings of female attractiveness is moderated by sociodemographic variables and whether ratings of shapeliness diverge from those of attractiveness. A community sample of 958 Italian participants rated the attractiveness and the shapeliness of 15 stimuli (5 breast sizes × 3 body s... περισσότερα »
The Retrocaruncular Approach to the Medial Orbit
Benefits of the Retrocaruncular Approach to the Medial Orbit: A Clinical And Anatomic Study: [image: image] Background: Current trends in the management of medial orbital wall fractures are toward the development of transconjunctival incisions and the use of endoscopic-assisted methods. Different authors have suggested variations of the medial transconjunctival approach. Methods: (1) In 30 fresh cadaver orbits, the classic transcaruncular approach was compared with the precaruncular and retrocaruncular approach under magnified dissection. (2) A retrospective analysis was conducted ...περισσότερα »
A Novel Lymphaticovenular Anastomosis Model
A Novel Lymphaticovenular Anastomosis Rat Model: [image: image]Introduction: Lymphaticovenular anastomosis (LVA) has become an important procedure for the surgical treatment of lymphedema. In the past, the anatomy of the lymphatic system of animal models has been reported. However, to our knowledge, there have been few reports of animal models of LVA including training model. In this study, we report on a relatively simple and ideal animal LVA model based on peritoneal lymph ducts and veins. Patients and Methods: For 10 rats, diameters of lumbar lymphatic ducts and iliolumbar veins ...περισσότερα »
Isolated Autologous Free Fat Grafting for Management of Facial Contour Asymmetry in a Subset of Growing Patients With Craniofacial Microsomia
Isolated Autologous Free Fat Grafting for Management of Facial Contour Asymmetry in a Subset of Growing Patients With Craniofacial Microsomia: [image: image]Background: To report autologous free fat grafting as an isolated procedure to manage facial contour asymmetry of a subset of growing patients with craniofacial microsomia (CFM). Methods: A retrospective analysis of CFM patients (n = 11) with low socioeconomic and intellectual status, poor oral hygiene, living far from our center, Pruzansky-Kaban I/II mandibles, without functional concerns, and with no craniofacial skeletal surg...περισσότερα »
Treatment of Velopharyngeal Insufficiency
Treatment of Velopharyngeal Insufficiency: Fifteen-Year Experience at the University of Florida: Introduction: A 15-year experience treating velopharyngeal insufficiency at the University of Florida is presented. After diagnostic speech evaluation, preoperative videofluoroscopy was the primary method used to evaluate the function of the velopharyngeal port. Methods: Chart reviews of all patients with velopharyngeal insufficiency, including patients with failed palatal cleft surgery, submucous cleft palate, and noncleft palate who met study criteria were included. Results: Overall su... περισσότερα »
The 16th Free Flap Harvesting Course in Living Tissue, Pius Branzeu Centre, Timisoara, Romania
Course Review: The 16th Free Flap Harvesting Course in Living Tissue, Pius Branzeu Centre, Timisoara, Romania: Abstract: The Free Flap Harvesting Course in Living Tissue is a 3-day course at the Pius Branzeu Centre in Timisoara, Romania held twice a year. The course allows participants 30 hours of operating time and covers the dissection of 9 different free flaps on porcine living tissue. Each flap is demonstrated live before dissection and the experienced course instructors are available at all times to assist participants with their surgery. There are up to 10 course participants ... περισσότερα »
Relationship Between Lymphedema and Arteriosclerosis: Higher Cardio-Ankle Vascular Index (CAVI) in Lymphedematous Limbs
Relationship Between Lymphedema and Arteriosclerosis: Higher Cardio-Ankle Vascular Index (CAVI) in Lymphedematous Limbs: [image: image]Background: Arteriosclerosis is one of the most important public health issues because it is very common in developed countries and its sequelae are lethal. Lymphatic vessel insufficiency has been reported to be associated with atherogenesis. Lymphedema seems to affect progression of arteriosclerosis, but no clinical study has been reported. Methods: Forty-eight limbs of 24 female patients with pelvic cancer-related lower extremity lymphedema (LEL) w...περισσότερα »
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation: [image: image]Background: Traumatic amputation is the second leading cause of limb loss in the United States. The preferred treatment is salvage and replantation of the amputated limb, whenever possible, and allotransplantation is a novel procedure whereby healthy limbs are procured from deceased organ donors and transplanted into the amputee recipient. A major restriction for both procedures is the irrecoverable muscle damage occurring due to ischemia. We investigated the feasibility of using a n...περισσότερα »
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.: Objectives: Listening to speech with multiple competing talkers requires the perceptual separation of the target voice from the interfering background. Normal-hearing listeners are able to take advantage of perceived differences in the spatial locations of competing sound sources to facilitate this process. Previous research suggests that bilateral (BI) cochlear-implant (CI) listeners cannot do so, and it is unknown whether single-sided deaf (SSD) CI ... περισσότερα »
The microbiome and development of allergic disease.
*The microbiome and development of allergic disease.: Purposes of review: First, to review how the global rise in prevalence of asthma prompted studies of the relationships between microbial exposure in early infancy, the rate and pattern of development of immune function, and the development of allergic sensitization and of wheezing in childhood. And, second, to review how those studies laid the groundwork for a possible strategy for primary prevention of asthma through manipulation of the microbiome of the gastrointestinal and/or respiratory tracts. Recent findings: Atopy an... περισσότερα »
Egyptian Journal of Bronchology
Biological therapy in severe asthma: A gem or a jam *Hesham Raafat* Egyptian Journal of Bronchology 2016 10(1):1-4 Severe asthma remain a great challenge for physicians. Several therapies are suggested. The only one proved to be effective in severe allergic asthma is Omalizumab. Other biological agents are in different phases in research, yet, only few of them proved some effectiveness in clinical trial. Recently Mepolizumab (a monoclonal antibody against interleukin-IL-5)was approved by the food and drug administration in United States of America (FDA) as an effective drug in seve... περισσότερα »
Journal of Craniovertebral Junction and Spine (J Craniovert Jun Spine)
*Table of Contents - Journal of Craniovertebral Junction and Spine (J Craniovert Jun Spine)2016 | January-March | Volume 7 | Issue 1* *EDITORIALS* *Central or axial atlantoaxial instability: Expanding understanding of craniovertebral junction [pg. 1]Atul Goel[ABSTRACT] [HTML FULL TEXT] [PDF] [Mobile HTML Full text ] [EPub]* *Iatrogeny of Alzheimer's disease: A view point [pg. 4]Manu Kothari, Lopa Mehta[ABSTRACT] [HTML FULL TEXT] [PDF] [Mobile HTML Full text ] [EPub]* *REVIEW ARTICLE* *Ligamentum flavum hematomas: Why does it mostly occur in old Asian males?... περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Effect of dehydroepiandroster... περισσότερα »
The Laryngoscope
*© The American Laryngological, Rhinological and Otological Society, Inc.Volume 126, Issue 3 Pages 539 - 781, E90 - E135, March 2016* *The latest issue of The Laryngoscope is available on Wiley Online Library* Issue Information *Masthead (pages 539–540)Article first published online: 16 FEB 2016 | DOI: 10.1002/lary.25614* *Table of contents (pages 541–545)Article first published online: 16 FEB 2016 | DOI: 10.1002/lary.25615* Triological Society Best Practice *Head and Neck* *How does depth of invasion influence the decision to do a neck dissection in clinically N0 oral cav... περισσότερα »
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
1. - Nodular Swelling of the Buccal Mucosa - *In Press, Accepted Manuscript, Available online 17 February 2016* - *Luciana Yamamoto Almeida, Darcy Fernandes, Túlio Morandin Ferrisse, Rose Mara Ortega, Daphine Caxias Travassos, Alfredo Ribeiro-Silva, Jorge Esquiche León, Andréia Bufalino* - *- First page PDF- Purchase PDF - $35.95* - * Not entitled to full text* 2. - - Submucosal Nodule in Buccal Mucosa - *In Press, Accepted Manuscript, Available online 17 February 2016* - *Natália Batista Daroit, Br... περισσότερα »
Associated Injuries in Geriatric Patients
are Frequent and Severe via Oral and Maxillofacial Surgery Publication date: Available online 17 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Miika Toivari, Anna Liisa Suominen, Christian Lindqvist, Hanna Thorén PurposeIt is hypothesized that facial trauma associated injuries (AI) are more frequent and severe in elderly than in younger adult patients. The purpose of the study was to determine the occurrence of, reasons for, and severity of AI in geriatric facial fractures, and to compare the differences between geriatric and younger adult patients.Materi... περισσότερα »
These new articles for Molecular Endocrinology are available online
These new articles for Molecular Endocrinology are available online ------------------------------ Early Release Molecular Endocrinology ------------------------------ [image: Molecular Endocrinology masthead] ------------------------------ ------------------------------ Molecular Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes Bing M. Liao, et al. | Molecular ... περισσότερα »
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.
Objectives: Listening to speech with multiple competing talkers requires the perceptual separation of the target voice from the interfering background. Normal-hearing listeners are able to take advantage of perceived differences in the spatial locations of competing sound sources to facilitate this process. Previous research suggests that bilateral (BI) cochlear-implant (CI) listeners cannot do so, and it is unknown whether single-sided deaf (SSD) CI users (one acoustic and one CI ear) have this ability. This study investigated whether providing a second ear via cochlear implantatio... περισσότερα »
Multiple sclerosis prevalence in the United States commercially insured population
Objective: To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. Methods: The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility during an entire year. Our primary annual MS identification algorithm required… Continue reading Multiple sclerosis prevalence in the United States commercially insured population
Dorsal horn circuitry: Complexity and implications for mechanisms of neuropathic pain
The transmission of pain involves several types of primary unmyelinated A- and unmyelinated C afferents from neurons in in the dorsal root (or trigeminal) ganglion; these afferents activate second-order spinothalamic and spinobulbar projection neurons in the dorsal horn (or trigeminal nucleus caudalis). The dorsal horn is not a simple relay station but rather a site… Continue reading Dorsal horn circuitry: Complexity and implications for mechanisms of neuropathic pain
Understanding migraine and psychiatric comorbidity.
Purpose of review: This article describes recent trends in our understanding of the role of psychiatric disorders in the experience and treatment of migraine, and the role of migraine in the experience and treatment of psychiatric disorders. Recent findings: Although the majority of studies evaluating psychiatric comorbidity in migraine have focused on depression, anxiety, and… Continue reading Understanding migraine and psychiatric comorbidity.
The migraine postdrome.
Purpose of review: Migraine is a common, disabling neurological disorder that affects up to 12% of the world population. Its pathophysiology is incompletely described. Of the various phases of migraine, the migraine postdrome is the least studied and hence the least understood. Recent findings: Electronic diary studies show patients are left disabled with non-headache symptoms… Continue reading The migraine postdrome.
First-line therapy for treatment-naive patients with advanced/metastatic renal cell carcinoma: a systematic review of published randomized controlled trials.
In the recent years, a number of targeted therapies have been approved for first-line treatment of patients with metastatic renal cell carcinoma. A systematic review was conducted to assess the clinical efficacy, safety and effect of all first-line treatments evaluated to date on health-related quality of life (HRQoL). A systematic search of Embase, Cochrane and… Continue reading First-line therapy for treatment-naive patients with advanced/metastatic renal cell carcinoma: a systematic review of published randomized controlled trials.
Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.
Objectives: Listening to speech with multiple competing talkers requires the perceptual separation of the target voice from the interfering background. Normal-hearing listeners are able to take advantage of perceived differences in the spatial locations of competing sound sources to facilitate this process. Previous research suggests that bilateral (BI) cochlear-implant (CI) listeners cannot do so, and… Continue reading Having Two Ears Facilitates the Perceptual Separation of Concurrent Talkers for Bilateral and Single-Sided Deaf Cochlear Implantees.
Acromio-axillo-suprasternal notch index: a new screening test to predict difficult laryngoscopy in obstetric patients scheduled for caesarean delivery.
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1oLMaSy via IFTTT
Use of rocuronium and sugammadex in renal transplantation: Problems that must be considered.
No abstract available from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1OhqxhN via IFTTT
Identifying optimal heparin management during cardiopulmonary bypass in obese patients: A prospective observational comparative study.
BACKGROUND: The heparin regimen providing anticoagulation during cardiopulmonary bypass (CPB) is usually adapted to total body weight (TBW), but may be inaccurate in obese patients in whom TBW exceeds their ideal body weight. OBJECTIVES: The objective is to compare the effects of heparin injection based on TBW on haemostatic parameters between obese and nonobese patients… Continue reading Identifying optimal heparin management during cardiopulmonary bypass in obese patients: A prospective observational comparative study.
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ A mechanism to enhance cellular responsivity to hormone action: Krüppel-like factor 9 promotes thyroid hormone receptor beta autoinduction during postembryonic brain develo... περισσότερα »
Response:
We would like to thank Hamada et al for their interest in our article and for their comments. The major differences between our study1 and previous studies of metal stents with an antireflux function2-5 were that a self-expandable metal stent (SEMS) with a longer valve length (18-20 mm) was used, and a barium meal examination for confirmation of duodenobiliary reflux was performed after biliary drainage in all patients. The newly developed SEMS with an antireflux valve (ARV) showed superior stent patency duration compared with the conventional covered SEMS (cSEMS), and duodenobili... περισσότερα »
It’s time to take the split-standard out of the split-prep
The prevention of colorectal cancer represents a true public health success story, marked by an increase in colonoscopy screening and an approximately 30% decrease in colorectal cancer incidence in individuals age 50 and older from 2001 to 2010.1 Although colonoscopy remains the criterion standard in colon cancer screening and prevention, ensuring and measuring quality in colonoscopy are essential to maximizing the efficacy of the procedure. Over the past decade, we have learned that there are significant differences in the adenoma detection rate (ADR) among individual endoscopists...περισσότερα »
Response:
We are grateful for Dr Berger's thoughtful comments on our editorial on the challenges of the DISCARD strategy.1 We offer a point-by-point commentary on the important issues he raises. from Endocrinology via ola Kala on Inoreader http://ift.tt/1R9ggIZ via IFTTT
Teaching endoscopic imaging should be more active
Daly et al1 undertook a study to compare the use of self-directed versus in-classroom teaching of narrow-band imaging for the diagnosis of Barrett's esophagus–associated neoplasia. They reported no significant difference in sensitivity, specificity, and accuracy of diagnosis between the 2 training methods. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2Merm via IFTTT
Reaching a milestone in continuous assessment of quality colonoscopy skills: adding an ace to our assessment toolbox
Quality colonoscopy starts with quality training. Training directors have the privilege and responsibility to teach learners until they are capable of performing safe and high-quality endoscopic procedures. Continuous assessment tools are needed by training directors to track the progress of their trainees so they can provide feedback for improvement, identify trainees who may benefit from more focused training, and ultimately verify in a summative evaluation that the trainee has demonstrated sufficient competence to enter practice without direct supervision. from Endocrinology vi... περισσότερα »
Response:
We appreciate the comments regarding our article.1 The appeal for complete definitions for performing future trials and meta-analysis is laudable. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2MeaS via IFTTT
It’s all about the loop: quality indicators in pediatric colonoscopy
If you are a fan of "popular" music, you have likely heard a catchy song by Meghan Trainor called "All about that Bass," which begins "Because you know I'm all about that bass, 'bout that bass, no treble"… and repeats 3 times in the opening verse. Given the chance to pick the 1 measure that distinguishes a high-quality colonoscopy procedure in pediatric patients from the rest, it would likely be the formation of the loop or, more importantly, the lack thereof, hence a slightly modified tune "it's all about the loop, 'bout the loop, no trouble." from Endocrinology via ola Kala on I... περισσότερα »
Discrepancy in the classification of water immersion from water exchange colonoscopy
We read with interest the article by Cadoni et al.1 Water exchange (WE) colonoscopy seems superior to water immersion (WI); however, there is a lack of consensus on the clear distinction between these 2 procedures.2,3 from Endocrinology via ola Kala on Inoreader http://ift.tt/1R9gfVn via IFTTT
Whither the hyperplastic and serrated polyp?
Whither: To whatever place, result, or condition, as in "Whither thou goest, I will go" (Ruth 1:16).Hyperplastic polyps are reminiscent of pesky dogs that refuse to go away. In the 1970s and 1980s, hyperplastic polyps were thought not to be precursors of colorectal cancer (CRC). In the 1980s, when flexible sigmoidoscopy was still a prominent modality for screening for colorectal cancer in the United States, whether distal hyperplastic polyps were a predictor of proximal neoplasia remained relevant. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2Mcjh via IFTTT
Resect and discard
I add 4 concerns to Wang and East's1 insights about DISCARD in clinical practice. First, DISCARD has been presented as a validated and accepted practice.2 However, as sure as we are of our abilities, remember that we were once sure that a complete colonoscopy completely ruled out any possibility of colon cancer. The pathology societies have certainly not endorsed DISCARD; why would we believe a "criteria" set at a concordance of 90% would be universally acceptable? Second, when the inevitable interval cancer occurs after a DISCARD colonoscopy, will that patient really believe our ...περισσότερα »
Hybrid endoscopic submucosal dissection in the colon: Cutting corners or trimming fat?
Endoscopic submucosal dissection (ESD) enables en bloc resection of large superficial neoplasms in the GI tract. Initially introduced for the removal of gastric neoplasms, its application has expanded to include esophageal and colorectal lesions. However, ESD is time-consuming, technically demanding, and carries a higher risk of perforation compared with EMR. Several anatomic features make colorectal ESD particularly challenging, including the thin-walled colon, prominent contractions, colon tortuosity or fixity, and the presence of lesions in difficult locations, such as colonic ... περισσότερα »
Against duodenobiliary reflux: implications from a randomized controlled trial
We read with great interest the article by Lee et al1 on the superiority of an antireflux valve metal stent (ARVMS) over a conventional covered self-expandable metal stent (SEMS) for distal malignant biliary obstruction. The duodenobiliary reflux is a well-recognized contributor to covered SEMS dysfunction,2-4 and ARVMSs have been expected to be a reasonable treatment option. from Endocrinology via ola Kala on Inoreader http://ift.tt/1R9ggsl via IFTTT
Erratum
In the Guideline, "The management of antithrombotic agents for patients undergoing GI endoscopy," prepared by the ASGE Standards of Practice Committee (Gastrointest Endosc 2016;83:3-16), there was an error in Table 2. The corrected table appears below. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2Mc2N via IFTTT
Colorectal cancer screening: 80% by 2018. Colonoscopists simply cannot do it alone
The National Colorectal Cancer Roundtable (NCCRT) initiative "80% by 2018" is a shared goal in which more than 300 healthcare organizations have committed to having 80% of adults aged 50 years and older regularly screened for colorectal cancer by 2018. A range of organizations have signed on to join this initiative, including hospitals, health systems, health insurers, specialty societies, advocacy groups, physician groups, and industry. Current colorectal cancer screening rates are estimated to be 65% by the Centers for Disease Control and Prevention,1 so this represents a major ... περισσότερα »
Contents
from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2MbMb via IFTTT
Continuing Medical Education Exam: March 2016
from Endocrinology via ola Kala on Inoreader http://ift.tt/1R9gdwT via IFTTT
Editors
from Endocrinology via ola Kala on Inoreader http://ift.tt/1Q2MbM2 via IFTTT
Neuroanesthesiology Update.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
We provide a synopsis of innovative research, recurring themes, and novel experimental findings pertinent to the care of neurosurgical patients and critically ill patients with neurological diseases. The following broad topics are covered: general neurosurgery, spine surgery, stroke, traumatic brain injury, anesthetic neurotoxicity, perioperative cognitive dysfunction, and monitoring. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1Q2PAKU via IFTTT
Cerebellar contributions to self-motion perception: evidence from patients with congenital cerebellar agenesis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
The cerebellum was historically considered a brain region dedicated to motor control but it has become clear that it also contributes to sensory processing, particularly when sensory discrimination is required. Prior work, for example, has demonstrated a cerebellar contribution to sensory discrimination in the visual and auditory systems. The cerebellum also receives extensive inputs from the motion and gravity sensors in the vestibular labyrinth, but its role in the perception of head motion and orientation has received little attention. Drawing on the lesion-deficit approach to ... περισσότερα »
Saccades create similar mislocalizations in visual and auditory space
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Orienting our eyes to a light, a sound or a touch occurs effortlessly, despite the fact that sound and touch have to be converted from head- and body-based coordinates to eye-based coordinates to do so. We asked whether the oculomotor representation is also used for localization of sounds even when there is no saccade to the sound source. To address this, we examined whether saccades introduced similar errors of localization judgments for both visual and auditory stimuli. Sixteen subjects indicated the direction of a visual or auditory apparent motion seen or heard between two targ...περισσότερα »
Influence of vigilance state on physiologic consequences of seizures and seizure-induced death in mice
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. SUDEP occurs more commonly during nighttime sleep. The details of why SUDEP occurs at night are not well understood. Understanding why SUDEP occurs at night during sleep might help to better understand why SUDEP occurs at all and hasten development of preventive strategies. Here we aimed to understand circumstances causing seizures that occur during sleep to result in death. Groups of twelve adult male mice were instrumented for EEG, EMG and EKG recording and subjected to... περισσότερα »
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
A large majority of neurons in the superficial layer of the dorsal horn project to the lateral parabrachial nucleus (LPB). LPB neurons then project to the capsular part of the CeA (CeC), a key structure underlying the nociception-emotion link. LPB-CeC synaptic transmission is enhanced in various pain models by using electrical stimulation of putative fibers of LPB origin in brain slices. However this approach has limitations for examining direct monosynaptic connections devoid of directly stimulating fibers from other structures and local GABAergic neurons. To overcome these limit... περισσότερα »
Hypergravity within a critical period impacts on the maturation of somatosensory cortical maps and their potential for use-dependent plasticity in the adult.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
We investigated experience-dependent plasticity of somatosensory maps in rat S1 cortex during early development. We analyzed both short- and long-term effects of exposure to 2G hypergravity (HG) during the first 3 postnatal weeks on forepaw representations. We also examined the potential of adult somatosensory maps for experience-dependent plasticity after early HG rearing. At P22, HG was found to induce an enlargement of cortical zones driven by nail displacements and a contraction of skin sectors of the forepaw map. In these remaining zones serving the skin, neurons displayed ex...περισσότερα »
Correlations between prefrontal neurons form a small world network that optimizes the generation of multineuron sequences of activity
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Sequential patterns of prefrontal activity are believed to mediate important behaviors, e.g. working memory, but it remains unclear exactly how they are generated. In accordance with previous studies of cortical circuits, we found that prefrontal microcircuits in young adult mice spontaneously generate many more stereotyped sequences of activity than expected by chance. However, the key question of whether these sequences depend on a specific functional organization within the cortical microcircuit, or emerge simply as a byproduct of random interactions between neurons, remains un... περισσότερα »
Odors Enhance Slow-Wave Activity in Non Rapid Eye Movement Sleep
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Most forms of supra-threshold sensory stimulation perturb sleep. In contrast, presentation of pure olfactory or mild trigeminal odorants does not lead to behavioral or physiological arousal. In fact, some odors promote objective and subjective measures of sleep quality in humans and rodents. The brain mechanisms underlying these sleep protective properties of olfaction remain unclear. Slow oscillations in the electroencephalogram (EEG) are a marker of deep sleep, and K-complexes (KCs) are an EEG marker of cortical response to sensory interference. We therefore hypothesized that od... περισσότερα »
A common control signal and a ballistic stage can explain the control of coordinated eye-hand movements
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Voluntary control has been extensively studied in the context of eye and hand movements made in isolation; yet little is known about the nature of control during eye-hand coordination. We probed this using a redirect task. Here subjects had to make reaching/pointing movements accompanied by coordinated eye movements, but had to change their plans when the target occasionally changed its position during some trials. Using a race model framework, we found that separate effector-specific mechanisms maybe recruited to control eye and hand movements when executed in isolation, but when...περισσότερα »
Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
For a slowly-varying stimulus, the simplest relationship between a neuron's input and output is a rate code, in which the spike rate is a unique function of the stimulus at that instant. In the case of spike-rate adaptation, there is no unique relationship between input and output, because the spike rate at any time depends both on the instantaneous stimulus and on prior spiking (the "history"). To improve the decoding of spike trains produced by neurons that show spike-rate adaptation, we developed a simple scheme that incorporates "history" into a rate code. We utilized this rat... περισσότερα »
Spectral breadth and laminar distribution of thalamocortical inputs to A1
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
The GABAergic agonist muscimol is used to inactivate brain regions in order to reveal afferent inputs in isolation. However, muscimol's use in primary auditory cortex (A1) has been questioned on the grounds that it may unintentionally suppress thalamocortical inputs. We tested whether muscimol can preferentially suppress cortical, but not thalamocortical, circuits in urethane-anesthetized mice. We recorded tone-evoked, current-source density (CSD) profiles to determine frequency receptive fields (RFs) for three current sinks: the "layer 4" sink (fastest-onset, middle-layer sink), a... περισσότερα »
Decreased heart rate and enhanced sinus arrhythmia during interictal sleep demonstrate autonomic imbalance in generalized epilepsy
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
We hypothesized that epilepsy affects the activity of the autonomic nervous system even in the absence of seizures, which should manifest as differences in heart rate variability (HRV) and cardiac cycle. To test this hypothesis, we investigated electrocardiogram (ECG) traces of 91 children and adolescents with generalized epilepsy and 25 neurologically normal controls during 30 minutes of stage 2 sleep with interictal or normal EEG. Mean heart rate (HR) and high-frequency HRV corresponding to respiratory sinus arrhythmia (RSA) were quantified and compared. Blood pressures (BP) fro... περισσότερα »
Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Viral vectors were originally developed to deliver genes into host cells for therapeutic potential. However, viral vector use in neuroscience research has increased because they enhance interpretation of the anatomy and physiology of brain circuits compared to conventional tract tracing or electrical stimulation techniques. Viral vectors enable neuronal or glial sub-populations to be labeled or stimulated, which can be spatially restricted to a single target nucleus or pathway. Here, we review the use of viral vectors to examine the structure and function of motor and limbic basal... περισσότερα »
Neuromagnetic correlates of adaptive plasticity across the hand-face border in human primary somatosensory cortex
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
It is well established that permanent or transient reduction of somatosensory inputs, following hand deafferentation or anesthesia, induces plastic changes across the hand-face border, supposedly responsible for some altered perceptual phenomena such as tactile sensations being referred from the face to the phantom hand. It is also known that transient increase of hand somatosensory inputs, via repetitive somatosensory stimulation (RSS) at a fingertip, induces local somatosensory discriminative improvement, accompanied by cortical representational changes in SI. We recently demons...περισσότερα »
An asymmetrical outer retinal response to drifting sawtooth gratings
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Electroretinogram (ERG) studies have demonstrated that the retinal response to temporally-modulated fast-ON and fast-OFF sawtooth flicker is asymmetrical. The response to spatiotemporal sawtooth stimuli has not yet been investigated. Perceptually, such drifting gratings or diamond plaids shaded in a sawtooth pattern appear brighter when movement produces fast-OFF relative to fast-ON luminance profiles. The neural origins of this illusion remain unclear (although a retinal basis has been suggested). Thus we presented toad eyecups with sequential epochs of sawtooth, sine-wave, and s...περισσότερα »
Testing the hypothesis of neurodegeneracy in respiratory network function with a priori transected arterially perfused brainstem preparation of rat.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Degeneracy of respiratory network function would imply that anatomically discrete aspects of the brainstem are capable of producing respiratory rhythm. To test this theory we a priori transected brainstem preparations before re-perfusion and re-oxygenation at 4 rostro-caudal levels: 1.5 mm caudal to obex (n=5), at obex (n=5), 1.5 mm (n=7) and 3mm (n=6) rostral to obex. The respiratory activity of these preparations was assessed via recordings of phrenic (PNA), vagal (VNA) nerves and lumbar spinal expiratory motor output (L1). Preparations with a priori transection at level of the ... περισσότερα »
Anesthesia complications of diazepam use for adolescents
Anesthesia complications of diazepam use for adolescents receiving extraction of third-molars via Oral and Maxillofacial Surgery Publication date: Available online 17 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Gino Inverso, Cory M. Resnick, Martin L. Gonzalez, Sung-Kiang Chuang PurposeTo evaluate the safety of using midazolam and diazepam for adolescents during third-molar extraction, and whether any differences in perioperative complications exist when using the two benzodiazepines alone or in combination.Materials and MethodsWe performed a prospective...περισσότερα »
Morphology and microchemistry of the otoliths of the inner ear
of anuran larvae via Hearing Research Publication date: Available online 16 February 2016 *Source:*Hearing Research Author(s): Agustín Bassó, Paola Mariela Peltzer, Rafael Carlos Lajmanovich, Andrés Maximiliano Attademo, Celina María Junges, Dante R. Chialvo To navigate in space most vertebrates need precise positional cues provided by a variety of sensors, including structures in the inner ear, which are exquisitely sensitive to gravity and linear acceleration. Although these structures have been described in many vertebrates, no information is available for anuran larvae. The purpo...περισσότερα »
The use of piezoelectric surgery to lateralize the inferior alveolar nerve
The use of piezoelectric surgery to lateralize the inferior alveolar nerve with simultaneous implant placement and immediate buccal cortical bone repositioning: a prospective clinical study: A prospective study was conducted to assess a variation of inferior alveolar nerve (IAN) lateralization. This study included 13 patients. An osteotomy was made with a piezoelectric device, and the IAN bundle was moved buccally. Dental implants were then inserted medial to the nerve bundle, and the inner surface of the buccal cortical bone plate was shaped to reduce its thickness. Finally, the bo... περισσότερα »
4D-CT evaluation of jaw movement following mandibular reconstruction
Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study: The purpose of this study was to analyze jaw movement during mastication of patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images.
A Stem Cell Factor with a Key Role in Pediatric Tumor Formation
LIN28: A Stem Cell Factor with a Key Role in Pediatric Tumor Formation: Stem Cells and Development , Vol. 0, No. 0. Author information Ilana Carmel-Gross,1 Naomi Bollag,1 Leah Armon,1 and Achia Urbach1 1The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. Address correspondence to: *Dr. Achia Urbach* *The Mina and Everard Goodman Faculty of Life Science* *Bar-Ilan University* *Ramat Gan 5290002* Israel *E-mail:* achia.urbach@biu.ac.il Received for publication October 7, 2015 Accepted after revision December 19, 2015 ABSTRACT Differentiation an... περισσότερα »
Cognition, temperament and cerebral blood flow velocity in toddlers and preschool children with sleep disordered breathing or behavioral insomnia of childhood
Cognition, temperament and cerebral blood flow velocity in toddlers and preschool children with sleep disordered breathing or behavioral insomnia of childhood: • We measured sleep, cognition, temperament and cerebral blood flow in young children• Sleep disordered breathing is associated with impaired visual and language reception• SDB is associated with temperamental problems vs controls and behavioral insomnia• SDB is associated with higher resting cerebral blood flow velocity• Cognition, temperament and cerebral blood flow are independent predictors of SDB
Rotigotine may improve sleep architecture in Parkinson's Disease
Rotigotine may improve sleep architecture in Parkinson's Disease: a double-blind, randomized, placebo-controlled polysomnographic study.: [image: sleep3012-fig-0001.sml] • Sleep disturbances are frequently encountered non-motor symptoms in Parkinson's Disease (PD).• The impact of dopaminergic therapies on sleep impairment in PD remains controversial.• Rotigotine improved sleep fragmentation by increasing sleep efficiency in PD patients.• Rotigotine induced the increase of REM sleep in PD patients.• The benefit of rotigotine on sleep may be related to its pharmacodynamic profile.
Omega-3 fatty acids as an adjunct for therapy
Omega-3 fatty acids as an adjunct for periodontal therapy—a review: Abstract ObjectivesThe aim of this article is to present an overview of omega-3 fatty acids, their anti-inflammatory properties and potential use as an adjunct for periodontal therapy. Materials and methodsA general literature search was conducted to provide an overview of omega-3 fatty acids, their metabolism and anti-inflammatory properties. A more specific literature search of PubMed and EMBASE was conducted to identify articles dealing studies investigating the effects of omega-3 fatty acids in the treatmen... περισσότερα »
Photodynamic inactivation of Klebsiella pneumoniae biofilms and planktonic cells by 5-aminolevulinic acid and 5-aminolevulinic acid methyl ester
Photodynamic inactivation of Klebsiella pneumoniae biofilms and planktonic cells by 5-aminolevulinic acid and 5-aminolevulinic acid methyl ester: AbstractThe treatment of *Klebsiella pneumoniae*, particularly extended-spectrum β-lactamase (ESBL)-producing *K. pneumoniae*, is currently a great challenge. Photodynamic antimicrobial chemotherapy is a promising approach for killing antibiotic-resistant bacteria. The aim of this study was to evaluate the capacity of 5-aminolevulinic acid (5-ALA) and its derivative 5-ALA methyl ester (MAL) in the presence of white light to cause photodyn...περισσότερα »
Cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser
Cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser: AbstractLow-level infrared laser is considered safe and effective for treatment of muscle injuries. However, the mechanism involved on beneficial effects of laser therapy are not understood. The aim was to evaluate cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser at therapeutic fluences. C2C12 myoblast cultures at different (2 and 10 %) fetal bovine serum (FBS) concentrations were exposed ... περισσότερα »
Sleep Bruxism and Sleep-Disordered Breathing
Sleep Bruxism and Sleep-Disordered Breathing: Abstract Sleep bruxism (SB) is a repetitive jaw muscle activity with clenching or grinding of the teeth during sleep. SB is characterized by what is known as rhythmic masticatory muscle activity (RMMA). RMMA is the laboratory polysomnographic finding that differentiates SB from other oromandibular movements seen during sleep. Most often RMMA episodes are associated with sleep arousal. Some patients will report similar complaints related to both SB and sleep disordered breathing (SDB). There are some reports that would suggest that SB is... περισσότερα »
Facial and Dental Measurements Using 3D-Stereophotogrammetry
Inter- and Intra-Operator Reliability of Facial and Dental Measurements Using 3D-Stereophotogrammetry: Abstract Objectives The goal of this study was to assess the reproducibility of an innovative method for facial analysis with three-dimensional-stereophotogrammetry (3D-spg). Methods Twelve subjects with no obvious malocclusion participated in this study. For each of them, four photographs were acquired using the LifeVizTM, an absolute calibration 3D-spg system. The facial reconstructions were analyzed with the DermaPixTM image management software. Two different operators recorded...περισσότερα »
Red and infrared laser therapy inhibits in vitro growth of major bacterial species that commonly colonize skin ulcers
Red and infrared laser therapy inhibits in vitro growth of major bacterial species that commonly colonize skin ulcers: AbstractLow-level laser therapy (LLLT) is used in chronic wounds due to its healing effects. However, bacterial species may colonize these wounds and the optimal parameters for effective bacterial inhibition are not clear. The aim of this study was to analyze the effect of LLLT on bacterial growth in vitro. Bacterial strains including *Staphylococcus aureus*, *Escherichia coli*, and *Pseudomonas aeruginosa* were suspended in saline solution at a concentration of 10... περισσότερα »
Helicobacter-negative gastritis: polymerase chain reaction for Helicobacter DNA is a valuable tool to elucidate the diagnosis
Helicobacter-negative gastritis: polymerase chain reaction for Helicobacter DNA is a valuable tool to elucidate the diagnosis: Summary Background *Helicobacter*-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis. Aim To evaluate of *Helicobacter *PCR in gastric biopsies for the daily diagnostics of *Helicobacter*-negative gastritis. Methods Over a 5-year period, routine biopsies with chronic gastritis reminiscent of *Helicobacter* infection, but negative by histol... περισσότερα »
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
Article TRAF family proteins regulate immune signalling cascades. Here, the authors show that TRAF3 is upregulated in the liver in non-alcoholic fatty liver disease, promoting insulin resistance, inflammation and hepatic steatosis via its interaction with the kinase TAK1. Nature Communications doi: 10.1038/ncomms10592 Authors: Pi-Xiao Wang, Xiao-Jing Zhang, Pengcheng Luo, Xi Jiang, Peng Zhang, Junhong Guo, […]
Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 40 δευτερόλεπτα
A large majority of neurons in the superficial layer of the dorsal horn project to the lateral parabrachial nucleus (LPB). LPB neurons then project to the capsular part of the CeA (CeC), a key structure underlying the nociception-emotion link. LPB-CeC synaptic transmission is enhanced in various pain models by using electrical stimulation of putative fibers […]
Wind dependence of ambient noise in a biologically rich coastal area
Wind dependence of ambient noise in a biologically rich coastal area: [image: cm_sbs_024_plain.png] The wind dependence of acoustic spectrum between 100 Hz and 16 kHz is investigated for coastal biologically rich areas. The analysis of 5 months of continuous measurements run in a 10 m deep shallow water environment off Brittany (France) showed that wind dependence of spectral levels is subject to masking by biological sounds. When dealing with raw data, the wind dependence of spectral levels was not significant for frequencies where biological sounds were present (2 to 10 kHz). An ... περισσότερα »
Behavioural estimates of auditory filter widths in ferrets using notched-noise maskers
Behavioural estimates of auditory filter widths in ferrets using notched-noise maskers: Frequency selectivity is a fundamental property of hearing which affects almost all aspects of auditory processing. Here auditory filter widths at 1, 3, 7, and 10 kHz were estimated from behavioural thresholds using the notched-noise method [Patterson, Nimmo-Smith, Weber, and Milroy, J. Acoust. Soc. Am. 72, 1788–1803 (1982)] in ferrets. The mean bandwidth was 21% of the signal frequency, excluding wider bandwidths at 1 kHz (65%). They were comparable although on average broader than equivalent m...περισσότερα »
Bi-allelic mutations in the SLC26A4 gene : Vestibular function is associated with residual low-frequency hearing loss
Vestibular function is associated with residual low-frequency hearing loss in patients with bi-allelic mutations in the SLC26A4 gene via Hearing Research Publication date: Available online 17 February 2016 *Source:*Hearing Research Author(s): Jinsei Jung, Young Wook Seo, Jae Young Choi, Sung Huhn Kim DFNB4 is non-syndromic, autosomal recessive type of hearing loss with an enlarged vestibular aqueduct (EVA) caused by mutations in SLC26A4/pendrin. Although the characteristics of hearing loss are well known in DFNB4, vestibular function remains inconclusive. We evaluated the vestibular f... περισσότερα »
Functional magnetic resonance imaging confirms forward suppression for rapidly alternating sounds in human auditory cortex but not in the inferior colliculus
Functional magnetic resonance imaging confirms forward suppression for rapidly alternating sounds in human auditory cortex but not in the inferior colliculus via Hearing Research Publication date: Available online 17 February 2016 *Source:*Hearing Research Author(s): Christian Harm Uhlig, Andrew R. Dykstra, Alexander Gutschalk Forward suppression at the level of the auditory cortex has been suggested to subserve auditory stream segregation. Recent results in non-streaming stimulation contexts have indicated that forward suppression can also be observed in the inferior colliculus; whet... περισσότερα »
Racial Variations in Velopharyngeal and Craniometric Morphology in Children: An Imaging Study
Racial Variations in Velopharyngeal and Craniometric Morphology in Children: An Imaging Study: Purpose The purpose of this study is to examine craniometric and velopharyngeal anatomy among young children (4–8 years of age) with normal anatomy across Black and White racial groups. Method Thirty-two healthy children (16 White and 16 Black) with normal velopharyngeal anatomy participated and successfully completed the magnetic resonance imaging scans. Measurements included 11 craniofacial and 9 velopharyngeal measures. Results Two-way analysis of covariance was used to determine th... περισσότερα »
Mcmaster University Tinnitus
Mcmaster University Tinnitus: ------------------------------ An Overview Of Tinnitus Tinnitus is a condition that affects millions of people in the world and can have a negative impact on their overall quality of life. It is a condition that causes constant buzzing or ringing in the ears. It is estimated that 20 percent of people in the world suffer from tinnitus. The exact causes of tinnitus have not been found. However, a team of researchers at McMaster University have provided us with a better understanding of the condition. The McMaster University Tinnitus Study The McMaste... περισσότερα »
Take charge of the airway with tunnel vision focus
Take charge of the airway with tunnel vision focus: Airway management: It's not easy. Catastrophic clinical failures, such as the one described in this article about Drew Hughes, serve as somber reminders about how challenging airway management truly is. Without an airway, patients do not live. Such a seemingly simple fact belies how difficult that can actually be to perform under a wide array of operating environments. Yet trainers and educators often minimize the dangers of inadequate airway management. When asked by a student about the status of a scenario patient's airway, we ... περισσότερα »
Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.
A Study of Cisplatin Plus Radiotherapy Compared to Cetuximab Plus Radiotherapy in Locally Advanced Head and Neck Cancer.: *Condition*: Locally Advanced Head and Neck Cancer. *Interventions*: Drug: cetuximab; Drug: cisplatin *Sponsor*: Lund University Hospital ArmsAssigned Interventions Experimental: Arm 1 Radiotherapy with a dose of 68.0 Gy in 34 fractions, and cetuximab with a loading dose of 400 mg/m2 one week before start of radiotherapy, then 250 mg/m2 weekly during radiotherapy (tumor stage 1-4). Drug: cetuximab Drug: cisplatin Experimental: Arm 2 Radiotherapy with a d...περισσότερα »
C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for Treatment of Cervical Radicular Pain
C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for Treatment of Cervical Radicular Pain: *Conditions*: Radicular; Neuropathic, Cervical; Neck Pain *Interventions*: Procedure: Interlaminar cervical epidural steroid injection; Procedure: Targeted cervical epidural steroid injections *Sponsor*: Northwestern University Cervical radicular pain is a common, disabling problem, occurs in 83:100,000 individuals per year. Symptoms are most often caused by intervertebral disc herniation (21.9%) or central or foraminal stenosis from spond... περισσότερα »
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.
Palliative Short-course Hypofractionated Radiotherapy Followed by Chemotherapy in Adenocarcinoma of the Esophagus or Esophagogastric Junction Trial - a Phase II Clinical Trial Protocol.: *Condition*: Adenocarcinoma of the Esophagus or Esophagogastric Junction. *Interventions*: Radiation: Radiation therapy; Drug: Oxaliplatin and fluorouracil. *Sponsor*: Lund University Hospital ArmsAssigned Interventions Experimental: Radiotherapy and chemotherapy (oxaliplatin and fluorouracil). Radiotherapy (5 x 4 Gy) will be given. After completion of radiotherapy, 4 cycles of chemotherap... περισσότερα »
Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog)
Biomarker Development for Postoperative Cognitive Impairment in the Elderly (BioCog): *Conditions*: Postoperative Delirium (POD); Postoperative Cognitive Deficit (POCD) *Intervention*: *Sponsors*: Charite University, Berlin, Germany; European Union The research leading consortium to these results has received funding from the European Union Seventh Framework Programme [FP7/2007-2013] under grant agreement no 602461 (www.biocog.eu). The investigators will establish valid biomarkers panels (neuroimaging and molecular) for risk and clinical outcome prediction of postoperat... περισσότερα »
Low-Level Laser Therapy for Prevention of Oral Mucositis
Low-Level Laser Therapy for Prevention of Oral Mucositis: *Condition*: Mucositis *Intervention*: Device: Low Level Laser Therapy *Sponsor*: University of Pittsburgh ArmsAssigned Interventions Experimental: Low Level Laser Therapy Patients meeting the eligibility criteria will be enrolled to receive prophylactic LLLT in addition to standard of care measures for oral mucositis or other toxicity of therapy. The radiation and chemotherapy dose, schedule, modality, technique, and any required adjustments will not be influenced by this protocol and will follow standard existing i... περισσότερα »
Study of Apatinib in Metastatic Esophageal Cancer
Study of Apatinib in Metastatic Esophageal Cancer: *Condition*: Esophageal Cancer *Interventions*: Drug: Apatinib; Drug: Apatinib *Sponsors*: Huai'an First People's Hospital; Jiangsu HengRui Medicine Co., Ltd. ArmsAssigned Interventions Experimental: Apatinib 500mg qd p.o. Apatinib Mesylate Tablets 500 mg qd p.o. after the failure of chemotherapy or radiotherapy Drug: Apatinib Apatinib 500mg qd p.o. Experimental: Apatinib 750mg qd p.o. Apatinib Mesylate Tablets 750 mg qd p.o. after the failure of chemotherapy or radiotherapy Drug: Apatinib Apatinib 750mg qd p.o. Detailed... περισσότερα »
Screening Trial of Nivolumab With Image Guided, Stereotactic Body Radiotherapy (SBRT) Versus Nivolumab Alone in Patients With Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Screening Trial of Nivolumab With Image Guided, Stereotactic Body Radiotherapy (SBRT) Versus Nivolumab Alone in Patients With Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC): *Condition*: Head and Neck Squamous Cell Carcinoma (HNSCC) *Interventions*: Drug: Nivolumab; Radiation: Stereotactic Body Radiation Therapy (SBRT) *Sponsors*: Memorial Sloan Kettering Cancer Center; University of Chicago ArmsAssigned Interventions Experimental: Nivolumab 3mg/kg IV every 2 weeks Nivolumab 3mg/kg IV every 2 weeks Drug: Nivolumab Experimental: Stereotactic Body Radiotherapy & ... περισσότερα »
Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism
Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism: Background. Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism. Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism. Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes. Objectives. This review focuses on the effects of prenatal expo... περισσότερα »
Gezielte Auslösung des laryngealen Adduktionsreflexes per Mikrotröpfchenabgabe
Gezielte Auslösung des laryngealen Adduktionsreflexes per Mikrotröpfchenabgabe: Zusammenfassung HintergrundDer laryngeale Adduktionsreflex (LAR) als reflektorischer Stimmlippenschlussmechanismus umfasst eine frühe, vermutlich di- oder oligosynaptisch verschaltete ipsilaterale LAR1- und eine späte polysynaptische ipsi- und kontralaterale LAR2-Komponente. Im Rahmen einer klinischen Dysphagieuntersuchung kann der LAR durch Luftimpulse oder taktil ausgelöst und typischerweise nur qualitativ beurteilt werden. MethodikEntwicklung und Konstruktion einer Vorrichtung, die gezielt sehr ... περισσότερα »
Prevalence and complications of MRI scans of cochlear implant patients
Prevalence and complications of MRI scans of cochlear implant patients: Abstract BackgroundCochlear implants (CI) are the preferred method of treatment for patients with severe to profound bilateral sensorineural hearing loss and unilateral deafness. For many years, because of the magnetic field applied during magnetic resonance imaging (MRI) examinations, MRI examinations were contraindicated for CI patients or feasible only under specific circumstances. MRI examinations of CI recipients entail complications and therefore preventive measures have to be considered. The aim of this ... περισσότερα »
Patient Evaluation for Head and Neck Surgery Branch Studies
Patient Evaluation for Head and Neck Surgery Branch Studies: *Conditions*: Head and Neck Neoplasms; Pharyngeal Cancer; Oral Cancer; Carcinoma, Squamous Cell; Laryngeal Cancer *Intervention*: *Sponsor*: National Institute on Deafness and Other Communication Disorders (NIDCD) This protocol offers evaluation and, in some cases, standard treatment for patients with head and neck cancer in NIDCD s Head and Neck Surgery Branch (HNSB). The study is not designed to test new treatments. Its purpose is twofold: 1) to identify patients who may be eligible for investigational ...περισσότερα »
Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus
Abstract Background Postoperative ileus (POI) is characterized by a transient inhibition of gastrointestinal (GI) motility after abdominal surgery mediated by the inflammation of the *muscularis externa* (ME). The aim of this study was to identify alterations in the enteric nervous system that may contribute to the pathogenesis of POI. Methods Gastrointestinal transit, contractility of isolated smooth muscle strips and inflammatory parameters were evaluated at different time points (1.5 h to 10 days) after intestinal manipulation (IM) in mice. Immune-labeling was used to visuali... περισσότερα »
Analysis of heterogeneous gallstones using laser-induced breakdown spectroscopy (LIBS) and wavelength dispersive X-ray fluorescence (WD-XRF)
Abstract Laser-induced breakdown spectroscopy (LIBS) is an emerging analytical technique with numerous advantages such as rapidity, multi-elemental analysis, no specific sample preparation requirements, non-destructiveness, and versatility. It has been proven to be a robust elemental analysis tool attracting interest because of being applied to a wide range of materials including biomaterials. In this paper, we have performed spectroscopic studies on gallstones which are heterogeneous in nature using LIBS and wavelength dispersive X-ray fluorescence (WD-XRF) techniques. It has been...περισσότερα »
Impact of CO 2 laser and stannous fluoride on primary tooth erosion
Abstract This study evaluated in vitro the effect of input power of CO2 laser, either associated or not to stannous fluoride (SnF2) gel, for the control of intrinsic erosion in primary teeth. One hundred four enamel slabs (3 × 3 × 2 mm) from human primary molars were flattened and polished. Adhesive tapes were placed on their surface leaving a window of 3 × 1 mm. Slabs were then cycled four times in 0.01 M hydrochloric acid (pH 2, 2 min) and in artificial saliva (2 h) for creation of erosive lesions. Specimens were randomly assigned into eight groups (*n* = 13) according to fluorid... περισσότερα »
Gaining an accurate reflection of the reality of palliative care through the use of free-text feedback in questionnaires: the AFTER study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Background In healthcare, many service evaluation questionnaires use free-text boxes without formal mechanisms for analysis. Patients and carers spend time documenting concerns that are often ignored or managed locally in an ad hoc manner. Currently, palliative care experiences of patients and carers in Wales are measured using a service evaluation questionnaire, comprising both closed and […]
Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Abstract Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba (CCMB) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the CLL clinic influences patient outcome. Overall survival (OS) was assessed for all CLL/SLL patients […]
An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment CLINICAL AND HUMAN IMMUNOLOGY
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Decidual macrophages are implicated in the local inflammatory response that accompanies spontaneous preterm labor/birth; however, their role is poorly understood. We hypothesized that decidual macrophages undergo a proinflammatory (M1) polarization during spontaneous preterm labor and that PPAR activation via rosiglitazone (RSG) would attenuate the macrophage-mediated inflammatory response, preventing preterm birth. In this study, we show […]
BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs INFECTIOUS DISEASE AND HOST RESPONSE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
A new class of highly antigenic, MHC-II–restricted mycobacterial lipopeptides that are recognized by CD4-positive T lymphocytes of Mycobacterium tuberculosis–infected humans has recently been described. To investigate the relevance of this novel class of mycobacterial Ags in the context of experimental bacille Calmette-Guérin (BCG) vaccination, Ag-specific T cell responses to mycobacterial lipid and lipopeptide-enriched Ag preparations […]
Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling INNATE IMMUNITY AND INFLAMMATION
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Complement factor B (cfB) is an essential component of the alternative pathway (AP) and plays an important role in the pathogenesis of polymicrobial sepsis. However, the mechanism leading to cfB production and AP activation during sepsis remains poorly understood. In this study, we found that plasma cell–free RNA was significantly increased following cecal ligation and […]
Patient Evaluation for Head and Neck Surgery Branch Studies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Conditions: Head and Neck Neoplasms; Pharyngeal Cancer; Oral Cancer; Carcinoma, Squamous Cell; Laryngeal Cancer Intervention: Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) Recruiting – verified January 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TrT7EW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
ETHNOMEDICAL AND ETHNOBOTANICAL INVESTIGATIONS ON THE RESPONSE CAPACITIES OF GUINEAN TRADITIONAL HEALTH PRACTIONERS IN THE MANAGEMENT OF OUTBREAKS OF INFECTIOUS DISEASES: THE CASE OF THE EBOLA VIRUS EPIDEMIC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Publication date: Available online 18 February 2016 Source:Journal of Ethnopharmacology Author(s): A.M. Baldé, M.S. Traoré, M.A. Baldé, M.S. Barry, A. Diallo, M. Camara, S. Traoré, M. Kouyaté, S. Traoré, S. Ouo-Ouo, A.L. Myanthé, N. Keita, N.L. Haba, K. Goumou, F. Bah, A. Camara, M.S.T. Diallo, M. Sylla, E.S. Baldé, S. Diané, L. Pieters L., K. […]
Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Publication date: 2 April 2016 Source:Journal of Ethnopharmacology, Volume 181 Author(s): G. Pérez-Ortega, M.E. González-Trujano, G.E. Ángeles-López, F. Brindis, H. Vibrans, R. Reyes-Chilpa Ethnopharmacological relevanceMorelos State is one of the most important regions of Mexico where several plant species are used in traditional medicine to influence central nervous system (CNS) activity; for example Tagetes lucida […]
Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Publication date: Available online 18 February 2016 Source:Journal of Ethnopharmacology Author(s): Faheema Siddiqui, Sabira Naqvi, Lubna Abidi, Shaheen Faizi, Lubna, Lubna Avesi, Talat Mirza, Ahsana Dar Farooq Ethanopharmacological relevanceOpuntia dillenii Haw (Nagphana) traditionally used against inflammation. The present study addressed the anti-inflammatory activity of O. dillenii derived methanol extract, fractions and pure compounds and their […]
Absence of low back pain to demarcate an episode: a prospective multicentre study in primary care
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 56 δευτερόλεπτα
Abstract Background It has been proposed that an episode of low back pain (LBP) be defined as: “a period of pain in the lower back lasting for more than 24 h preceded and followed by a period of at least 1 month without LBP”. Previous studies have tested the definition in the general population and […]
Relationship between uric acid levels and progressive supranuclear palsy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
ABSTRACT Introduction The pathophysiology of both PD and PSP is characterized by a pro-oxidant state. Uric acid is an oxidative stress marker. High uric acid blood levels have been associated with a reduced risk of PD and a decreased rate of disease progression. We investigated whether a low serum concentration of uric acid is also […]
‘Deadpool’: How Fox Turned Risque Superhero Into A Summer Smash In The Dead Of Winter – Deadline
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Deadline ‘Deadpool’: How Fox Turned Risque Superhero Into A Summer Smash In The Dead Of Winter Deadline What’s the trick to opening an R-rated Marvel superhero film to a worldwide gross of $284.5M? Make sure your marketing campaign stays true to your film’s protagonist. In the case of 20th Century Fox’s near-yearlong promotion of Deadpool […]
MyD88 and Inflammation in Gastric Tumorigenesis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
It has been established that COX-2 and downstream signaling by prostaglandin E2 (PGE2) play a key role in tumorigenesis through generation of inflammatory microenvironment. Toll-like receptor (TLR) signaling through myeloid differentiation factor 88 (MyD88) also regulates inflammatory responses in tumors. However, the relationship between these distinct pathways in tumorigenesis is not yet fully understood. We […]
Knee
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Knee: The knee is a joint which has three parts. The thigh bone (the femur) meets the large shin bone (the tibia) to form the main knee joint. This joint has an inner (medial) and an outer (lateral) compartment. The kneecap (the patella) joins the femur to form a third joint, called the patellofemoral joint. […]
Combination of 5-fluorouracil and 2-morphilino-8-phenyl-4H-chromen-4-one may inhibit liver cancer stem cell activity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Abstract This work aims to evaluate the impact of 2-morpholino-8-phenyl-4H-chromen-4-one (LY294002) combined 5-fluorouracil (5-FU) for the activity of CD90+ liver cancer cells derived from the human liver cancer cell line MHCC97H. MHCC97H sphere-forming cells (MSFCs) were amplified in serum-free medium and CD90+ cells were isolated from bulk MSFCs using flow cytometry. The phenotype of these […]
Clinical outcomes in 995 unselected real-world patients treated with an ultrathin biodegradable polymer-coated sirolimus-eluting stent: 12-month results from the FLEX Registry
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objectives To evaluate, in the FLEX Registry, clinical outcomes of an ultrathin (60 µm) biodegradable polymer-coated Supraflex sirolimus-eluting stent (SES) for the treatment of coronary artery disease. Additionally, to determine the vascular response to the Supraflex SES through optical coherence tomography (OCT) analysis. Setting Multicentre, single-arm, all-comers, observational registry of patients who were treated with […]
Sleep duration and mortality in the elderly: a systematic review with meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective The purpose of our study was to evaluate the association between short and long sleep duration and all-cause and cardiovascular mortality among elderly individuals. Design Systematic review and meta-analysis of population-based cohort studies. Setting Articles were retrieved from international and national electronic databases. Study selection Studies were identified in PubMed, EMBASE, LILACS (Latin American […]
Acknowledging unreported problems with active surveillance for prostate cancer: a prospective single-centre observational study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective To report outcomes of patients with localised prostate cancer (PCa) managed with active surveillance (AS) in a standard clinical setting. Design Single-centre, prospective, observational study. Setting Non-academic, average-size hospital in Switzerland. Participants Prospective, observational study at a non-academic, average-size hospital in Switzerland. Inclusion and progression criteria meet general recommendations. 157 patients at a median […]
How do scientists perceive the current publication culture? A qualitative focus group interview study among Dutch biomedical researchers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective To investigate the biomedical scientist’s perception of the prevailing publication culture. Design Qualitative focus group interview study. Setting Four university medical centres in the Netherlands. Participants Three randomly selected groups of biomedical scientists (PhD, postdoctoral staff members and full professors). Main outcome measures Main themes for discussion were selected by participants. Results Frequently perceived […]
Understanding vulnerability to self-harm in times of economic hardship and austerity: a qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 58 δευτερόλεπτα
Objective Self-harm and suicide increase in times of economic recession, but little is known about why people self-harm when in financial difficulty, and in what circumstances self-harm occurs. This study aimed to understand events and experiences leading to the episode of self-harm and to identify opportunities for prevention or mitigation of distress. Setting Participants’ homes […]
Response:
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
We would like to thank Hamada et al for their interest in our article and for their comments. The major differences between our study1 and previous studies of metal stents with an antireflux function2-5 were that a self-expandable metal stent (SEMS) with a longer valve length (18-20 mm) was used, and a barium meal examination […]
It’s time to take the split-standard out of the split-prep
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The prevention of colorectal cancer represents a true public health success story, marked by an increase in colonoscopy screening and an approximately 30% decrease in colorectal cancer incidence in individuals age 50 and older from 2001 to 2010.1 Although colonoscopy remains the criterion standard in colon cancer screening and prevention, ensuring and measuring quality in […]
Response:
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
We are grateful for Dr Berger’s thoughtful comments on our editorial on the challenges of the DISCARD strategy.1 We offer a point-by-point commentary on the important issues he raises. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1R9ggIZ via IFTTT
Teaching endoscopic imaging should be more active
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Daly et al1 undertook a study to compare the use of self-directed versus in-classroom teaching of narrow-band imaging for the diagnosis of Barrett’s esophagus–associated neoplasia. They reported no significant difference in sensitivity, specificity, and accuracy of diagnosis between the 2 training methods. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Q2Merm via IFTTT
Reaching a milestone in continuous assessment of quality colonoscopy skills: adding an ace to our assessment toolbox
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Quality colonoscopy starts with quality training. Training directors have the privilege and responsibility to teach learners until they are capable of performing safe and high-quality endoscopic procedures. Continuous assessment tools are needed by training directors to track the progress of their trainees so they can provide feedback for improvement, identify trainees who may benefit from […]
Response:
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
We appreciate the comments regarding our article.1 The appeal for complete definitions for performing future trials and meta-analysis is laudable. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Q2MeaS via IFTTT
It’s all about the loop: quality indicators in pediatric colonoscopy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
If you are a fan of “popular” music, you have likely heard a catchy song by Meghan Trainor called “All about that Bass,” which begins “Because you know I’m all about that bass, ‘bout that bass, no treble”… and repeats 3 times in the opening verse. Given the chance to pick the 1 measure that […]
Discrepancy in the classification of water immersion from water exchange colonoscopy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
We read with interest the article by Cadoni et al.1 Water exchange (WE) colonoscopy seems superior to water immersion (WI); however, there is a lack of consensus on the clear distinction between these 2 procedures.2,3 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1R9gfVn via IFTTT
Whither the hyperplastic and serrated polyp?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Whither: To whatever place, result, or condition, as in “Whither thou goest, I will go” (Ruth 1:16).Hyperplastic polyps are reminiscent of pesky dogs that refuse to go away. In the 1970s and 1980s, hyperplastic polyps were thought not to be precursors of colorectal cancer (CRC). In the 1980s, when flexible sigmoidoscopy was still a prominent […]
Resect and discard
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
I add 4 concerns to Wang and East’s1 insights about DISCARD in clinical practice. First, DISCARD has been presented as a validated and accepted practice.2 However, as sure as we are of our abilities, remember that we were once sure that a complete colonoscopy completely ruled out any possibility of colon cancer. The pathology societies […]
Focus on...
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ASGE update
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In upcoming issues...
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Mutant Screen Report: Microarray Analysis of Gene Expression in S. cerevisiae kap108{Delta} Mutants Upon Addition of Oxidative Stress.
Protein transport between the nucleus and cytoplasm of eukaryotic cells is tightly regulated, providing a mechanism for controlling intracellular localization of proteins and regulating gene expression. In this study, we have investigated the importance of nucleocytoplasmic transport mediated by the karyopherin Kap108 in regulating cellular responses to oxidative stress in *Saccharomyces cerevisiae*. We carried out microarray analyses on wild type and *kap108* mutant cells grown under normal conditions, shortly after introduction of oxidative stress, after one hour of oxidative str... περισσότερα »
Mapping of Variable DNA Methylation across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation and cancer at a genome-wide scale. Our understanding of genome-wide DNA methylation changes in a developmental or disease-related context has been steadily growing. However, the investigation of which CpGs are variably methylated in different normal cell or tissue types is still limited. Here we present an in-depth analysis of 54 single-CpG-resolution DNA methylomes of normal ... περισσότερα »
Genome-Based Selection and Characterization of Fusarium circinatum-Specific Sequences
*Fusarium circinatum* is an important pathogen of pine trees and its management in the commercial forestry environment relies largely on early detection, particularly in seedling nurseries. The fact that the entire genome of this pathogen is available opens new avenues for the development of diagnostic tools for this fungus. In this study we identified open reading frames (ORFs) unique to *Fusarium circinatum* and determined that they were specific to the pathogen. The ORF identification process involved bioinformatics-based screening of all the putative *F. circinatum* ORFs again... περισσότερα »
Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species
It is now clear that the exploration of the genetic and phenotypic diversity of non-model species greatly improves our knowledge in biology. In this context, we recently launched a population genomic analysis of the protoploid yeast *Lachancea kluyveri* (formerly *Saccharomyces kluyveri*), highlighting a broad genetic diversity ( = 17 x 10-3) compared to the yeast model organism, *Saccharomyces cerevisiae* ( = 4 x 10-3). Here, we sought to generate a comprehensive view of the phenotypic diversity in this species. In total, 27 natural *L. kluyveri* isolates were subjected to trait ... περισσότερα »
Editorial: In Celebration of the Centennial of the Johns Hopkins University Bloomberg School of Public Health
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RE: "ESTIMATING CAUSAL ASSOCIATIONS OF FINE PARTICLES WITH DAILY DEATHS IN BOSTON"
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Cultivating Hygiene as a Science: The Welch-Rose Report's Influence at Johns Hopkins and Beyond
In 1915, William Henry Welch and Wickliffe Rose submitted a report to the Rockefeller Foundation that became the template for public health professional education in the United States and abroad. Based on the Welch-Rose Report's recommendations, the Foundation awarded a grant to Johns Hopkins University in 1916 to establish the first independent graduate school of public health, with Welch serving as the founding dean. The Welch-Rose Report and, by extension, the Johns Hopkins School of Hygiene and Public Health established and transmitted a new model of scientific training that w...περισσότερα »
Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study
The purpose of this study was to analyze jaw movement during mastication of patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1Oh38gj via IFTTT
Singly-qualified medical senior house officer in oral and maxillofacial surgery: perspectives from a unit
Publication date: Available online 17 February 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Kohmal Solanki, Nabeel Bhatti, Christopher Bridle Despite constituting a minority of senior house officers (SHO) in oral and maxillofacial surgery (OMFS), the number of singly-qualified medical trainees is growing. We describe the experience of a singly qualified medical trainee in OMFS and the unique benefits and opportunities for potential trainees and the department. Overall, the advantages of synergistic training outweigh any deficiencies in knowledge, and in ... περισσότερα »
The Arf GTPase-activating protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network Protein Structure and Folding
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ASAP1 regulates F-actin-based structures and functions, including focal adhesions (FAs) and circular dorsal ruffles (CDRs), cell spreading and migration. ASAP1 function requires its N-terminal BAR domain. We discovered that nonmuscle myosin 2A (NM2A) directly bound the BAR-PH tandem of ASAP1 in vitro. ASAP1 and NM2A co-immunoprecipitated and colocalized in cells. Knockdown of ASAP1 reduced colocalization […]
Soft Computational Approaches for Prediction and Estimation of Software Development
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba (CCMB) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the CLL clinic influences patient outcome. Overall survival (OS) was assessed for all CLL/SLL patients […]
Absence of low back pain to demarcate an episode: a prospective multicentre study in primary care
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Background It has been proposed that an episode of low back pain (LBP) be defined as: “a period of pain in the lower back lasting for more than 24 h preceded and followed by a period of at least 1 month without LBP”. Previous studies have tested the definition in the general population and […]
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the immune response to cancer. […]
Seven signs of cancer that can be easy to miss – AOL UK
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
AOL UK Seven signs of cancer that can be easy to miss AOL UK You might know the more common symptoms of cancer, but it’s worth knowing about the more subtle signs too. Of course, not every ache and pain means the worst – but if you’re concerned or notice other symptoms, it’s worth making […]
A single generation of domestication heritably alters the expression of hundreds of genes
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article Little is known about the genetic underpinnings of the earliest stages of plant and animal domestication. Here, the authors show that steelhead trout respond to a single generation of domestication selection with large, heritable changes in expression of genes regulating immunity and metabolism. Nature Communications doi: 10.1038/ncomms10676 Authors: Mark R. Christie, Melanie L. Marine, […]
Subintimale Rekanalisation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Zusammenfassung Klinisches/methodisches Problem Die vorliegende Übersichtsarbeit soll über den gegenwärtigen Stellenwert der sog. subintimalen Rekanalisation in der unteren Extremität informieren. Radiologische Standardverfahren Das primäre technische Ziel jeder endovaskulären Intervention an der unteren Extremität ist die endoluminale Wiederherstellung des Blutflusses von der Beckenachse bis in den Fuß. Methodische Innovationen War eine endoluminale Rekanalisation bei z. B. höchstgradigen […]
Parotidectomy for Parotid Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 17 February 2016 Source:Otolaryngologic Clinics of North America Author(s): Jennifer R. Cracchiolo, Ashok R. Shaha Teaser Parotidectomy for parotid cancer includes management of primary salivary cancer, metastatic cancer to lymph nodes, and direct extension from surrounding structures or cutaneous malignancies. Preoperative evaluation should provide surgeons with enough information to plan a […]
Nanotwin-governed toughening mechanism in hierarchically structured biological materials
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article As a natural biocomposite, Strombus gigas , commonly known as the giant pink queen conch shell, exhibits outstanding mechanical properties such as fracture toughness. Here, the authors show that these properties can be partially attributed to nanoscale twin boundaries in the basic building block of the shell. Nature Communications doi: 10.1038/ncomms10772 Authors: Yoon Ah […]
Intraoperative intravital microscopy permits the study of human tumour vessels
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article Intravital microscopy has been used in laboratory animals to visualise the blood vessels in tumours. Here, the authors use this technique in melanoma patients undergoing surgery and show that vessels in situ have a larger diameter than excised tissue Nature Communications doi: 10.1038/ncomms10684 Authors: Daniel T. Fisher, Jason B. Muhitch, Minhyung Kim, Kurt C. […]
Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) patients in Manitoba are either referred to the CLL Clinic at CancerCare Manitoba (CCMB) or are followed by other hematologists and general practitioners. However, it has been unclear whether referral to the CLL clinic influences patient outcome. Overall survival (OS) was assessed for all CLL/SLL patients […]
A four-coordinate cobalt(II) single-ion magnet with coercivity and a very high energy barrier
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Article Bistable single-molecule magnets potentially allow information storage at extremely high densities. Here, the authors study an air- and moisture-stable mononuclear tetrahedral cobalt(II) complex, elucidating the origin of its pronounced magnetic bistability. Nature Communications doi: 10.1038/ncomms10467 Authors: Yvonne Rechkemmer, Frauke D. Breitgoff, Margarethe van der Meer, Mihail Atanasov, Michael Hakl, Milan Orlita, Petr Neugebauer, Frank […]
Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation
Publication date: Available online 18 February 2016 Source:Journal of Ethnopharmacology Author(s): Faheema Siddiqui, Sabira Naqvi, Lubna Abidi, Shaheen Faizi, Lubna, Lubna Avesi, Talat Mirza, Ahsana Dar Farooq Ethanopharmacological relevanceOpuntia dillenii Haw (Nagphana) traditionally used against inflammation. The present study addressed the anti-inflammatory activity of O. dillenii derived methanol extract, fractions and pure compounds and their… Continue reading Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation
Absence of low back pain to demarcate an episode: a prospective multicentre study in primary care
Abstract Background It has been proposed that an episode of low back pain (LBP) be defined as: “a period of pain in the lower back lasting for more than 24 h preceded and followed by a period of at least 1 month without LBP”. Previous studies have tested the definition in the general population and… Continue reading Absence of low back pain to demarcate an episode: a prospective multicentre study in primary care
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
Article Blocking immune checkpoints is a promising strategy to treat lung cancer, but patients often become resistant to the therapy. Here, the authors analyse resistance in mouse models of lung cancer and show in mice and two patients, an increase in the expression of TIM3, which is also involved in the immune response to cancer.… Continue reading Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
A single generation of domestication heritably alters the expression of hundreds of genes
Article Little is known about the genetic underpinnings of the earliest stages of plant and animal domestication. Here, the authors show that steelhead trout respond to a single generation of domestication selection with large, heritable changes in expression of genes regulating immunity and metabolism. Nature Communications doi: 10.1038/ncomms10676 Authors: Mark R. Christie, Melanie L. Marine,… Continue reading A single generation of domestication heritably alters the expression of hundreds of genes
Nanotwin-governed toughening mechanism in hierarchically structured biological materials
Article As a natural biocomposite, Strombus gigas , commonly known as the giant pink queen conch shell, exhibits outstanding mechanical properties such as fracture toughness. Here, the authors show that these properties can be partially attributed to nanoscale twin boundaries in the basic building block of the shell. Nature Communications doi: 10.1038/ncomms10772 Authors: Yoon Ah… Continue reading Nanotwin-governed toughening mechanism in hierarchically structured biological materials
Intraoperative intravital microscopy permits the study of human tumour vessels
Article Intravital microscopy has been used in laboratory animals to visualise the blood vessels in tumours. Here, the authors use this technique in melanoma patients undergoing surgery and show that vessels in situ have a larger diameter than excised tissue Nature Communications doi: 10.1038/ncomms10684 Authors: Daniel T. Fisher, Jason B. Muhitch, Minhyung Kim, Kurt C.… Continue reading Intraoperative intravital microscopy permits the study of human tumour vessels
A four-coordinate cobalt(II) single-ion magnet with coercivity and a very high energy barrier
Article Bistable single-molecule magnets potentially allow information storage at extremely high densities. Here, the authors study an air- and moisture-stable mononuclear tetrahedral cobalt(II) complex, elucidating the origin of its pronounced magnetic bistability. Nature Communications doi: 10.1038/ncomms10467 Authors: Yvonne Rechkemmer, Frauke D. Breitgoff, Margarethe van der Meer, Mihail Atanasov, Michael Hakl, Milan Orlita, Petr Neugebauer, Frank… Continue reading A four-coordinate cobalt(II) single-ion magnet with coercivity and a very high energy barrier
Two distinctive energy migration pathways of monolayer molecules on metal nanoparticle surfaces
Article Energy migrations at metal nanomaterial surfaces are fundamentally important to heterogeneous reactions. Here, the authors employ ultrafast vibrational spectroscopy to show two distinctive energy migration pathways of monolayer adsorbate molecules on differently sized metal nanoparticle surfaces. Nature Communications doi: 10.1038/ncomms10749 Authors: Jiebo Li, Huifeng Qian, Hailong Chen, Zhun Zhao, Kaijun Yuan, Guangxu Chen, Andrea… Continue reading Two distinctive energy migration pathways of monolayer molecules on metal nanoparticle surfaces
Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour
Article The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits. Nature Communications doi: 10.1038/ncomms10583 Authors: Masao Doi, Iori Murai, Sumihiro Kunisue, Genzui Setsu, Naohiro Uchio,… Continue reading Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour
Seven signs of cancer that can be easy to miss – AOL UK
AOL UK Seven signs of cancer that can be easy to miss AOL UK You might know the more common symptoms of cancer, but it’s worth knowing about the more subtle signs too. Of course, not every ache and pain means the worst – but if you’re concerned or notice other symptoms, it’s worth making… Continue reading Seven signs of cancer that can be easy to miss – AOL UK
Mutant Screen Report: Microarray Analysis of Gene Expression in S. cerevisiae kap108{Delta} Mutants Upon Addition of Oxidative Stress.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Protein transport between the nucleus and cytoplasm of eukaryotic cells is tightly regulated, providing a mechanism for controlling intracellular localization of proteins and regulating gene expression. In this study, we have investigated the importance of nucleocytoplasmic transport mediated by the karyopherin Kap108 in regulating cellular responses to oxidative stress in *Saccharomyces cerevisiae*. We carried out microarray analyses on wild type and *kap108* mutant cells grown under normal conditions, shortly after introduction of oxidative stress, after one hour of oxidative str... περισσότερα »
Mapping of Variable DNA Methylation across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation and cancer at a genome-wide scale. Our understanding of genome-wide DNA methylation changes in a developmental or disease-related context has been steadily growing. However, the investigation of which CpGs are variably methylated in different normal cell or tissue types is still limited. Here we present an in-depth analysis of 54 single-CpG-resolution DNA methylomes of normal ... περισσότερα »
Genome-Based Selection and Characterization of Fusarium circinatum-Specific Sequences
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
*Fusarium circinatum* is an important pathogen of pine trees and its management in the commercial forestry environment relies largely on early detection, particularly in seedling nurseries. The fact that the entire genome of this pathogen is available opens new avenues for the development of diagnostic tools for this fungus. In this study we identified open reading frames (ORFs) unique to *Fusarium circinatum* and determined that they were specific to the pathogen. The ORF identification process involved bioinformatics-based screening of all the putative *F. circinatum* ORFs again... περισσότερα »
Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
It is now clear that the exploration of the genetic and phenotypic diversity of non-model species greatly improves our knowledge in biology. In this context, we recently launched a population genomic analysis of the protoploid yeast *Lachancea kluyveri* (formerly *Saccharomyces kluyveri*), highlighting a broad genetic diversity ( = 17 x 10-3) compared to the yeast model organism, *Saccharomyces cerevisiae* ( = 4 x 10-3). Here, we sought to generate a comprehensive view of the phenotypic diversity in this species. In total, 27 natural *L. kluyveri* isolates were subjected to trait ... περισσότερα »
ydfD Encodes a Novel Lytic Protein in Escherichia coli
Bacteria carry a number of genes that cause cell growth arrest or cell lysis upon expression. Notably, defective prophages retain many lysis proteins. Here, we identified a novel lytic gene, *ydfD*, on the Qin prophage segment of the *E. coli* genome. YdfD lyses 99.9% of cells within 2 hours of its induction. The co-expression of the upstream gene, *dicB*, encoding a cell division inhibitor, as well as *sulA*, encoding another cell division inhibitor, abolished YdfD-induced cell lysis. These results imply that YdfD-induced lysis is a cell division-dependent event. We further found... περισσότερα »
Streamlining Screening to Treatment: The Hepatitis C Cascade of Care at Kaiser Permanente Mid-Atlantic States
Gaps exist for hepatitis C virus (HCV) screening, diagnosis, and triage to treatment. We describe a new HCV cascade of care that screens at-risk populations and links infected patients to care. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1U9mag0 via IFTTT
Chemotherapy Mass Campaigns and Migratory Flows: an unexpected connection
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1Xz0b1J via IFTTT
Lessons learned from a randomized study of oral valganciclovir versus parenteral ganciclovir treatment of CMV-disease in solid organ transplant patients - The VICTOR trial.
In addition to showing non-inferiority for oral valganciclovir compared to intravenous ganciclovir for treatment of CMV disease, the VICTOR-biobank was used in a series of *post hoc* analyses which yielded unique and clinically valuable insights into CMV treatment and pathogenesis. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1Xz0cmk via IFTTT
Mucosal serotonin overflow is associated with colonic stretch rather than phasic contractions
Abstract Background Many studies have shown that mucosal serotonin (5-HT) is associated with motility, however, recently there have been some questions to the precise role of this transmitter. The majority of studies have focused on understanding the role of mucosal 5-HT on colonic migratory motor complexes, but very few studies have been carried out to understand how 5-HT release may be associated with other motility patterns. Methods Using distal colon segments from C57BL/6J mice, mucosal 5-HT overflow was monitored using amperometry while applying tension in longitudinal or c...περισσότερα »
High-resolution manometry in patients with eosinophilic esophagitis under topical steroid therapy—a prospective observational study (HIMEOS-study)
Abstract Background In eosinophilic esophagitis (EoE), dysphagia, which might reflect esophageal dysmotility, is the most common symptom. High-resolution manometry (HRM) has become widely accepted for evaluating esophageal motility disorders, but to date has been sparsely examined in EoE patients, particularly under therapy. The aim of this study was to evaluate HRM in symptomatic EoE-patients under topical steroid treatment. Methods In this prospective observational study, symptomatic EoE patients received HRM-examinations before and after 8 weeks of topical steroid treatment wi...περισσότερα »
National disparities in minimally invasive surgery for rectal cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Background Social and racial disparities have been identified as factors contributing to differences in access to care and oncologic outcomes in patients with colorectal cancer. The aim of this study was to investigate national disparities in minimally invasive surgery (MIS), both laparoscopic and robotic, across different racial, socioeconomic and geographic populations of patients with rectal cancer. Methods We utilized the American College of Surgeons National Cancer Database to identify patients with rectal cancer from 2004 to 2011 who had undergone definitive surgic... περισσότερα »
Impact of single-incision laparoscopic cholecystectomy (SILC) versus conventional laparoscopic cholecystectomy (CLC) procedures on surgeon stress and workload: a randomized controlled trial
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Abstract Introduction Single-incision laparoscopic cholecystectomy (SILC) may lead to higher patient satisfaction; however, SILC may expose the surgeon to increased workload. The goal of this study was to compare surgeon stress and workload between SILC and conventional laparoscopic cholecystectomy (CLC). Methods During a double-blind randomized controlled trial comparing patient outcomes for SILC versus CLC (NCT0148943), surgeon workload was assessed by four measures: surgery task load index questionnaire (Surg-TLX), maximum heart rate, salivary cortisol level, and instruments us...περισσότερα »
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