Cerebellar ataxia as presenting feature of hypothyroidism.
Related Articles *Cerebellar ataxia as presenting feature of hypothyroidism.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Kotwal SK, Kotwal S, Gupta R, Singh JB, Mahajan A Abstract Symptoms and signs of the hypothyroidism vary in relation to the magnitude and acuteness of the thyroid hormone deficiency. The usual clinical features are constipation, fatigue, cold intolerance and weight gain. Rarely it can present with neurologic problems like reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis and coma. Hypothyroidism should be suspected in all cases of ataxi... περισσότερα »
Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents.
Related Articles *Clustering of risk factors for cardiometabolic diseases in low-income, female adolescents.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Melo EM, Azevedo GD, Silva JB, Lemos TM, Maranhão TM, Freitas AK, Spyrides MH, Costa EC Abstract Objective To assess the prevalence and clustering patterns of cardiometabolic risk factors among low-income, female adolescents. Materials and methods Cross-sectional study involving 196 students of public schools (11-19 years old). The following risk factors were considered in the analysis: excess weight, central obesity, dyslipid...περισσότερα »
Mean platelet volume in patients with prolactinoma.
Related Articles *Mean platelet volume in patients with prolactinoma.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Tam AA, Kaya C, Başer H, Ersoy R, Çakır B Abstract Objective Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment ... περισσότερα »
Assessment of the left ventricular function in normotensive prediabetics: a tissue Doppler echocardiography study.
Related Articles *Assessment of the left ventricular function in normotensive prediabetics: a tissue Doppler echocardiography study.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Akçay M, Aslan AN, Kasapkara HA, Ayhan H, Durmaz T, Keleş T, Bozkurt E Abstract Objective Several studies have shown that left ventricular (LV) dysfunction is increased in individuals with diabetes. However, there are scarce data about LV function in prediabetics. This study assessed the early changes in LV diastolic and systolic myocardial function in normotensive prediabetics using tissue Doppler echo... περισσότερα »
TSH reference values in the first trimester of gestation and correlation between maternal TSH and obstetric and neonatal outcomes: a prospective Brazilian study.
Related Articles *TSH reference values in the first trimester of gestation and correlation between maternal TSH and obstetric and neonatal outcomes: a prospective Brazilian study.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Rosario PW, Carvalho M, Calsolari MR Abstract Objective To define the normal range of TSH in the first trimester of gestation and to evaluate the correlation between maternal TSH and obstetric and neonatal outcomes. Subjects and methods Prospective study. Women without known or clinically suspected thyroid disease and without risk factors for thyroid dysfun...περισσότερα »
Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus.
Related Articles *Evaluation of biochemical and clinical markers of endothelial dysfunction and their correlation with urinary albumin excretion in patients with type 1 diabetes mellitus.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Polat SB, Ugurlu N, Aslan N, Cuhaci N, Ersoy R, Cakir B Abstract Objective Endothelial dysfunction (ED) plays an important role in the pathogenesis of diabetic nephropathy. The purpose of the study was to determine flow mediated endothelial dependent vasodilatation (FMD) measurements and serum soluble (s) endothelin-1 (ET-1), intercellular adhesion ... περισσότερα »
Mutation screening of the SLC26A4 gene in a cohort of 192 Chinese patients with congenital hypothyroidism.
Related Articles *Mutation screening of the SLC26A4 gene in a cohort of 192 Chinese patients with congenital hypothyroidism.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Fu C, Zheng H, Zhang S, Chen Y, Su J, Wang J, Xie B, Hu X, Fan X, Luo J, Li C, Chen R, Shen Y, Chen S Abstract Objective Pendred syndrome (PS) is an autosomal recessive disorder characterised by sensorineural hearing loss and thyroid dyshormonogenesis. It is caused by biallelic mutations in the SLC26A4 gene encoding for pendrin. Hypothyroidism in PS can be present from birth and therefore diagnosed by neonatal ... περισσότερα »
Clinical, hormonal and radiological features of partial Sheehan's syndrome: an Indian experience.
Related Articles *Clinical, hormonal and radiological features of partial Sheehan's syndrome: an Indian experience.* Arch Endocrinol Metab. 2016 Feb 16; Authors: Laway B, Misgar R, Mir S, Wani A Abstract Objective The objective of this study was to describe clinical presentation, hormonal profile and imaging characteristics of 21 patients with partial Sheehan's syndrome. Subjects and methods This prospective study was carried out over a period of six years (2008-2013). The evaluation of patients included clinical assessment, hormone estimations and contrast enhanced magnetic res...περισσότερα »
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.
Objective: To determine whether exaggerating the variations in fundamental frequency (F0) contours of Mandarin-based pitch fluctuations could improve tone identification by cochlear implant (CI) users. Methods: Twelve normal-hearing (NH) listeners and 11 CI users were tested for their ability to recognize F0 contours modeled after Mandarin tones, in 4- or 5-alternatives forced-choice paradigms. Two types of stimuli were used: computer-generated complex tones and voice recordings. Four contours were tested with voice recordings: flat, rise, fall, and dip. A fifth contour, peak, was a... περισσότερα »
Acute care surgery and emergency general surgery
Acute care surgery and emergency general surgery: Addition by subtraction.: Introduction: The formation of Acute Care Surgery (ACS) leads to decreased time to treatment and improved outcomes for emergency general surgery (EGS) patients. However, minimal work has focused on the ideal care delivery system and team structure. We hypothesize that the implementation of a dedicated EGS team (separate from trauma and surgical critical care), with EGS-specific protocols and dedicated operating room (OR) time, will increase productivity and improve mortality. Methods: This is a retrospective...περισσότερα »
Assessment of lifesaving traumatic hemorrhage and airway management skills.
Feasibility of a perfused and ventilated cadaveric model for assessment of lifesaving traumatic hemorrhage and airway management skills.: Background: Training healthcare providers to manage common life-threatening traumatic injuries is an important endeavor. A fresh perfused cadaveric model with high anatomic and tissue fidelity was developed in order to assess performance of hemorrhage and airway management skills during a simulated polytrauma scenario. Methods: Fresh human cadavers were obtained within 96 hours of death. Hemorrhage from a right traumatic amputation and left inguin...περισσότερα »
Randomized controlled trial comparing dynamic simulation to static simulation in trauma.
Randomized controlled trial comparing dynamic simulation to static simulation in trauma.: Introduction: Current general surgery residents have limited exposure to open trauma operative cases. Simulation supplements variable rotation volume and provides experience with critical but rarely performed procedures. Open simulation classically focuses on static models with anatomic accuracy, but lacks practicality when hemorrhage control is the life-saving maneuver. We sought to evaluate whether training on a dynamic simulator, while much less expensive than training on a static cadaver, m... περισσότερα »
Diagnosis and Treatment of Ventilator-Associated Infection
Diagnosis and Treatment of Ventilator-Associated Infection: Review of the Critical Illness Stress-Induced Immune Suppression Prevention Trial Data.: Objectives: The Critical Illness Stress-Induced Immune Suppression prevention trial was a randomized, masked trial of zinc, selenium, glutamine, and metoclopramide compared with whey protein in delaying nosocomial infection in PICU patients. One fourth of study subjects were diagnosed with nosocomial lower respiratory infection, which contributed to subjects receiving antibiotics 74% of all patient days in the PICU. We analyzed diagnosti...περισσότερα »
Optimal Chest Compression Position for Patients With a Single Ventricle During Cardiopulmonary Resuscitation.
Optimal Chest Compression Position for Patients With a Single Ventricle During Cardiopulmonary Resuscitation.: Objectives: Few studies have examined cardiopulmonary resuscitation for patients with congenital heart disease, although they are at a high risk of cardiac arrest. Therefore, this study investigated the optimal chest compression position in patients with a single ventricle while providing them with basic life support. Design: This is a retrospective study of patients with a single ventricle who are undergoing chest CT. Setting: Tertiary teaching children's hospital. Patien... περισσότερα »
Facial Mimicry and Emotion Perception in Unilateral Facial Paralysis
*Facial Mimicry and Emotion Perception in Unilateral Facial Paralysis: This study evaluates the effects of unilateral facial paralysis on the recognition of and judgments about facial expressions of emotion. * *Importance The ability of patients with unilateral facial paralysis to recognize and appropriately judge facial expressions remains underexplored.* *Objective To test the effects of unilateral facial paralysis on the recognition of and judgments about facial expressions of emotion and to evaluate the asymmetry of facial mimicry.* *Design, Setting, and Participants P... περισσότερα »
Reconstructive Rhinoplasty Using Multiplanar Carved Costal Cartilage
Reconstructive Rhinoplasty Using Multiplanar Carved Costal Cartilage: This review of 11 reconstructive rhinoplasty cases seeks to describe an approach to cartilage carving whereby a single block of cartilage is carved in a multiplanar manner to mimic or redefine the anatomic relationships and resist warping. mportance Reconstructive rhinoplasty often requires the use of cartilage grafts. Full-thickness autologous costal cartilage grafts provide a large amount of cartilage in a single uncarved block and are often used for major reconstructions. Warping is frequently described as ... περισσότερα »
Extra and Intramuscular Distribution of the Thoracodorsal Nerve with Regard to Nerve Reconstruction Surgeries
Extra and Intramuscular Distribution of the Thoracodorsal Nerve with Regard to Nerve Reconstruction Surgeries: J reconstr Microsurg DOI: 10.1055/s-0036-1579541 Background The lateral branch of the thoracodorsal nerve (LBTN) is used for nerve transfer in facial, musculocutaneous, axillary nerve injuries and for irreparable C5, C6 spinal nerve lesions and accessory nerve defects. For a successful surgical outcome, the nerve to be used in nerve transfer should be of adequate length and thickness for nerve coaptation. Aim Our objective was to evaluate the length of the LBTN that could ... περισσότερα »
The Full and Short Scar Face Lift Incision Techniques
A Comparison of the Full and Short Scar Face Lift Incision Techniques in Four Sets of Identical Twins & One Set of Identical Triplets1,2.: Background: Choosing the ideal face lift technique for a patient presents an added challenge for the plastic surgeon. With the multitude of well-established variations of this procedure, it would be beneficial to define which facialplasty techniques produces the most optimal result. By comparing the postoperative results from two of the most popularized face lift incision techniques in monozygotic twins it is hypothesized that the 'best' techniqu...περισσότερα »
Pediatric nasal dermoid
Update on current evaluation and management of pediatric nasal dermoid: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To review the presentation of congenital pediatric nasal dermoid and present guidelines for its evaluation and management. Study Design Retrospective chart review from 1970 to 2014 at a tertiary referral children's hospital. Methods The medical records of all patients diagnosed with a nasal dermoid during the study period were reviewed for demographics, lesion characteristics, imaging, operative details, and outcomes. Results Ninety-six pa... περισσότερα »
Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction
Variations of mucosal-sparing septectomy for endonasal approach to the craniocervical junction: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis Recent advances in surgical techniques have rendered the craniocervical junction (CCJ) accessible transnasally. Endoscopic endonasal transclival and transodontoid approaches are routinely performed in leading skull base centers. Usually, these approaches involve a posterior bony and mucosal septectomy, which may compromise the vascularized pedicled nasoseptal flap (PNSF), a robust reconstructive option for repair ... περισσότερα »
Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck
Evaluation of Afatinib in Maintenance Therapy in Squamous Cell Carcinoma of the Head and Neck: *Condition*: Head and Neck Squamous Cell Carcinoma *Interventions*: Drug: AFATINIB; Drug: Placebo of AFATINIB *Sponsors*: Centre Leon Berard; Boehringer Ingelheim ArmsAssigned Interventions Experimental: AFATINIB Radiotherapy combined with a chemotherapy by Cisplatin IV at the dose of 100mg/m2 every 3 weeks, followed by a maintenance therapy with BIBW 2992 for 1 year at the dose of 40 mg/during the 1st month and then 50 mg/d during the 11 following months Drug: AFATINIB AFATINIB... περισσότερα »
The Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma
Phase II Study of the Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma: *Condition*: Thyroid Carcinoma *Interventions*: Drug: Continuous pazopanib (Arm A); Drug: Intermittent pazopanib (Arm B) *Sponsors*: Centre Leon Berard; GlaxoSmithKline ArmsAssigned Interventions Active Comparator: Continuous pazopanib (Arm A) Daily oral administration of pazopanib 800mg (28 days cycles) from randomization until progression (according to RECIST 1.1) under treatment, after an initial period of 6 cycles (28 days) of daily administration of pazopanib 800mg from inclusi... περισσότερα »
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma
Induction docetaxel and S-1 followed by concomitant radiotherapy with low-dose daily cisplatin in locally advanced head and neck carcinoma: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to assess the efficacy and safety of induction chemotherapy with docetaxel-S-1, and radiotherapy (RT) with concurrent daily cisplatin in locally advanced head and neck carcinoma. Method Fifty patients received 2 cycles of induction chemotherapy with induction chemotherapy with docetaxel and S-1, followed by 7 cycles of RT with concurrent daily ...περισσότερα »
Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma
Association between multidisciplinary team care approach and survival rates in patients with oral cavity squamous cell carcinoma: Abstract Background The purpose of this study was to investigate whether multidisciplinary team care (MDTC) is associated with outcomes in oral cavity squamous cell carcinoma (SCC). Methods We retrospectively examined 1616 patients with oral cavity SCC who underwent radical surgery between 1996 and 2011. The study participants were classified into 2 subgroups according to the use of MDTC. Results Five-year outcomes were significantly better in the MDTC gro...περισσότερα »
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis
Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis: Abstract Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total cervical metastases and occult metastases rate was 32%...περισσότερα »
Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy
Risk of swallowing-related chest infections in patients with nasopharyngeal carcinoma treated with definitive intensity-modulated radiotherapy: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background Pulmonary complications secondary to dysphagia may be encountered in patients with nasopharyngeal carcinoma (NPC) after definitive intensity-modulated radiotherapy. The purpose of this study was to identify patients with NPC at risk of developing swallowing-related chest infections (SRCIs). Methods Retrospective chart review was performed on 217 patients with stage I to...περισσότερα »
Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review
Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: A systematic review: Abstract Narrow band imaging (NBI) is reported to improve the diagnostic accuracy of head and neck cancers. The purpose of this review was to evaluate the diagnostic accuracy of NBI in the literature. A systematic review was performed in PubMed, Web of Knowledge, and the Cochrane Library until March 2015. Two reviewers independently assessed articles and extracted data. Meta-analyses were performed in MetaDisc 1.6. Five hundred seventeen studies were identified and 17 were included ...περισσότερα »
James William Osborne, PhD 1928–2015
Radiation Research, Volume 185, Issue 2, Page 214-216, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1RblnrX via IFTTT
Errata
Radiation Research, Volume 185, Issue 2, Page e52-e52, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1UbjrCL via IFTTT
Enhancement of Peroxidase Release from Non-Malignant and Malignant Cells through Low-Dose Irradiation with Different Radiation Quality
Radiation Research, Volume 185, Issue 2, Page 199-213, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1RbllAC via IFTTT
Inter-Relationship between Low-Dose Hyper-Radiosensitivity and Radiation-Induced Bystander Effects in the Human T98G Glioma and the Epithelial HaCaT Cell Line
Radiation Research, Volume 185, Issue 2, Page 124-133, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1OiMZqF via IFTTT
Investigating the Radioresistant Properties of Lung Cancer Stem Cells in the Context of the Tumor Microenvironment
Radiation Research, Volume 185, Issue 2, Page 169-181, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1Rblkwj via IFTTT
Examining Radiation-Induced In Vivo and In Vitro Gene Expression Changes of the Peripheral Blood in Different Laboratories for Biodosimetry Purposes: First RENEB Gene Expression Study
Radiation Research, Volume 185, Issue 2, Page 109-123, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1Ubjm1U via IFTTT
Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation
Radiation Research, Volume 185, Issue 2, Page 190-198, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1Rblkg1 via IFTTT
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2–/– (C57BL/6) Mice
Radiation Research, Volume 185, Issue 2, Page 134-150, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1Ubjm1H via IFTTT
Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability
Radiation Research, Volume 185, Issue 2, Page 182-189, February 2016. from Radiology via ola Kala on Inoreader http://ift.tt/1RbllAk via IFTTT
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Iodine supplementation of mil... περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High Fat Diet Miyuki Shibata, e... περισσότερα »
Commentary on ‘Predictors of 1 Year Survival After Endovascular Aneurysm Repair’
Publication date: Available online 18 February 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): A. Lejay, N. Chakfé from Endocrinology via ola Kala on Inoreader http://ift.tt/1KtLKu1 via IFTTT
Commentary on ‘Rupture of Abdominal Aortic Aneurysms in Patients under Screening Age and Elective Repair Threshold’
Publication date: Available online 18 February 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): S.K. Kakkos, I.A. Tsolakis from Endocrinology via ola Kala on Inoreader http://ift.tt/1orXK50 via IFTTT
Patient safety during Sedation by Anesthesia Professionals during Routine Upper Endoscopy and Colonoscopy: An Analysis of 1.38 Million Procedures
Sedation directed by anesthesia professionals (ADS) for GI endoscopy is used with the intent to improve throughput and patient satisfaction. However, data on its safety are sparse due to the lack of adequately powered randomized controlled trials comparing it with endoscopist directed sedation (EDS). This study was intended to determine whether ADS provides a safety advantage when compared with EDS for esophagogastroduodenoscopy (EGD) and colonoscopy. from Endocrinology via ola Kala on Inoreader http://ift.tt/1RboIYg via IFTTT
Role of EUS Evaluation after Endoscopic Eradication of Esophageal Varices with Band Ligation
Variceal recurrence after endoscopic band ligation (EBL) for secondary prophylaxis is a frequent event. Some studies have reported a correlation between variceal recurrence and variceal re-bleeding with the EUS features of para-esophageal vessels. A prospective observational study was conducted to correlate EUS evaluation of para-esophageal varices, azygos vein and thoracic duct with variceal recurrence after EBL variceal eradication in patients with cirrhosis. from Endocrinology via ola Kala on Inoreader http://ift.tt/1Tps9fK via IFTTT
Growth velocity in prepubertal children using both inhaled and intranasal corticosteroids
Publication date: Available online 18 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Laura Lasmar, Paul L.P. Brand, Anna Carolina Lustosa Lima, Maria Fernanda Maciel, Paulo Camargos from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1PUt3fN via IFTTT
Smokeless tobacco use and fractional exhaled nitric oxide in men in a national survey
Publication date: Available online 18 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Alem Mehari, Chad Hines, R.F. Gillum BackgroundTobacco use is an important risk for asthma and increases asthma severity. Fractional exhaled nitric oxide (FeNO) is used as a noninvasive biomarker of eosinophilic airway inflammation. Substantial numbers of men use smokeless tobacco. The effect of use of smokeless tobacco on FeNO is not known.ObjectiveTo estimate the association between use of smokeless tobacco and FeNO among US men.MethodsThe National Health and Nutrition Ex... περισσότερα »
Allergy and immunology inpatient and emergency department consultations at a pediatric academic medical center
Publication date: Available online 18 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Erin Kempe, David R. Stukus, Kasey Strothman, Rebecca Scherzer from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1PUt0Aw via IFTTT
Randomized controlled trial comparing dynamic simulation to static simulation in trauma.
Introduction: Current general surgery residents have limited exposure to open trauma operative cases. Simulation supplements variable rotation volume and provides experience with critical but rarely performed procedures. Open simulation classically focuses on static models with anatomic accuracy, but lacks practicality when hemorrhage control is the life-saving maneuver. We sought to evaluate whether training on a dynamic simulator, while much less expensive than training on a static cadaver, might be at least as effective in training surgery residents to expeditiously place tempora...περισσότερα »
Case Series Applying Extracorporeal Liver Support for Trauma-Induced Hepatic Dysfunction ELS in Hepatic Trauma.
No abstract available from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1KtW2ui via IFTTT
Feasibility of a perfused and ventilated cadaveric model for assessment of lifesaving traumatic hemorrhage and airway management skills.
Background: Training healthcare providers to manage common life-threatening traumatic injuries is an important endeavor. A fresh perfused cadaveric model with high anatomic and tissue fidelity was developed in order to assess performance of hemorrhage and airway management skills during a simulated polytrauma scenario. Methods: Fresh human cadavers were obtained within 96 hours of death. Hemorrhage from a right traumatic amputation and left inguinal wound was simulated using cannulation of the right popliteal and left femoral artery, respectively. The thoracic aorta (thoracotomy met...περισσότερα »
Acute care surgery and emergency general surgery: Addition by subtraction.
Introduction: The formation of Acute Care Surgery (ACS) leads to decreased time to treatment and improved outcomes for emergency general surgery (EGS) patients. However, minimal work has focused on the ideal care delivery system and team structure. We hypothesize that the implementation of a dedicated EGS team (separate from trauma and surgical critical care), with EGS-specific protocols and dedicated operating room (OR) time, will increase productivity and improve mortality. Methods: This is a retrospective review of financial and EGS registry data from fiscal year (FY) 12 to FY15.... περισσότερα »
Infected hardware after surgical stabilization of rib fractures: Outcomes and management experience.
Background: Surgical stabilization of rib fracture (SSRF) is increasingly used for treatment of rib fractures. There are few data on the incidence, risk factors, outcomes, and optimal management strategy for hardware infection in these patients. We aimed to develop and propose a management algorithm to help others treat this potentially morbid complication. Methods: We retrospectively searched a prospectively collected rib fracture database for the records of all patients who underwent SSRF from August 2009 through March 2014 at our institution. We then analyzed for the subsequent d...περισσότερα »
Do Basketball Players Have a High Risk of Pulmonary Embolism? A Scoping Review
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Pulmonary embolism (PE) is a serious preventable disease that requires urgent care. In recent years, there have been several reports in the media about basketball players experiencing PE. The aim of the present study was to assess whether there is a need for in-depth studies to determine whether basketball players constitute a group particularly at risk of PE and to describe some hypotheses to be investigated. Methods: We reviewed original articles about PE among professional and amateur basketball players in the scientific literature (PubMed) and the Internet... περισσότερα »
Hip Abductor Muscle Weakness in Individuals with Gluteal Tendinopathy
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: This study aimed to compare hip abductor muscle strength between individuals with symptomatic, unilateral gluteal tendinopathy (GT), and asymptomatic controls. Methods: Fifty individuals with GT age between 35 and 70 yr and 50 sex- and age-comparable controls were recruited from the community. Maximal isometric strength (torque normalized to body mass) of the hip abductors was recorded in the supine position using an instrumented manual muscle tester. A two-way mixed ANCOVA, with covariates of self-reported pain during testing and pain limiting maximum effort,...περισσότερα »
A Catecholamine Precursor Does Not Influence Exercise Performance in Warm Conditions
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Acute doses of Sinemet® (l-DOPA combined with carbidopa) previously failed to influence prolonged exercise performance in a temperate environment, but it is not known whether acute doses of l-DOPA timed to reach maximum plasma concentrations (Cmax) during exercise will improve prolonged cycling performance in warm conditions (30.2°C ± 0.2°C, 50% ± 1%). Methods: Ten physically active men (age, 26 ± 4 yr; height, 1.76 ± 0.08 m; body mass, 76.3 ± 10.6 kg; V˙O2peak, 57 ± 8 mL·kg−1·min−1) were recruited for this study. Participants cycled for 1 h at 60% V˙O2peak fo... περισσότερα »
Influence of the Metaboreflex on Pulmonary Vascular Capacitance in Heart Failure
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: An impaired metaboreflex is associated with abnormal ventilatory and peripheral vascular function in heart failure (HF), whereas its influence on cardiac function or pulmonary vascular pressure remains unclear. We aimed to assess whether metabolite-sensitive neural feedback (metaboreflex) from locomotor muscles via postexercise regional circulatory occlusion (RCO) attenuates pulmonary vascular capacitance (GXCAP) and/or circulatory power (CircP) in patients with HF. Methods: Eleven patients with HF (NYHA class, I/II; ages, 51 ± 15 yr; ejection fraction, 32% ± 9...περισσότερα »
Architectural Changes of the Biceps Femoris Long Head after Concentric or Eccentric Training
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: To determine the architectural adaptations of the biceps femoris long head (BFlh) after concentric or eccentric strength training interventions and the time course of adaptation during training and detraining. Methods: Participants in this intervention (concentric training group [n = 14], eccentric training group [n = 14], male subjects) completed a 4-wk control period, followed by 6 wk of either concentric- or eccentric-only knee flexor training on an isokinetic dynamometer and finished with 28 d of detraining. Architectural characteristics of BFlh were asses... περισσότερα »
Heart Rate and V˙O2 Concordance in Continuous-Flow Left Ventricular Assist Devices
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]The American College of Sports Medicine currently recommends the HR reserve (HRR) method to guide exercise in individuals who have heart failure with reduced ejection fraction. This recommendation is based on the known association between %HRR and percentage of V˙O2 reserve (%V˙O2R) in this population. However, to our knowledge, no studies exist regarding this relation in individuals with a left ventricular assist device (LVAD). Purpose: This article aimed to describe the relation between V˙O2 and surrogate markers of exercise intensity among patients with LVAD. Methods...περισσότερα »
Clinical Pathology for Athletic Trainers: Recognizing Systemic Disease, 3rd Edition
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
No abstract available from #Rehabilitation via ola Kala on Inoreader http://ift.tt/20IeBN4 via IFTTT
The Mechanoreflex and Hemodynamic Response to Passive Leg Movement in Heart Failure
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Background: Sensitization of mechanosensitive afferents, which contribute to the exercise pressor reflex, has been recognized as a characteristic of patients with heart failure (HF); however, the hemodynamic implications of this hypersensitivity are unclear. Objectives: The present study used passive leg movement (PLM) and intrathecal injection of fentanyl to blunt the afferent portion of this reflex arc to better understand the role of the mechanoreflex on central and peripheral hemodynamics in HF. Methods: Femoral blood flow (FBF), mean arterial pressure, femoral vas... περισσότερα »
Low-Active Male Adolescents: A Dose Response to High-Intensity Interval Training
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: High-intensity interval training (HIIT) is a potential alternative to traditionally recommended steady state exercise for providing health benefits in adolescents, yet its dose–response relationship in this cohort remains unclear, as does its translatability to real-world, nonclinical settings. The present study adopts a novel dose–response design to investigate the effects of undertaking 8 wk of HIIT on the cardiometabolic health of low-active male adolescents. Methods: Twenty-six male adolescents (age 16 ± 1 yr), identified as low active by nonparticipation ... περισσότερα »
Ventilation Increases with Lower Extremity Venous Occlusion in Young Adults
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Introduction: Venous distention via subsystolic occlusion of the lower limbs may augment ventilation via stimulation of group III/IV afferent neurons. Purpose: The purpose of this study was to examine the ventilatory response to graded lower extremity venous occlusion during exercise in healthy adults. Methods: Nineteen adults (9 men, 25 ± 5 yr) completed two visits. Visit 1 included a maximal cycle ergometry exercise test. Visit 2 included a 30% peak workload cycle exercise with randomized inflations of bilateral thigh pressure tourniquets to 20, 40, 60, 80, and 100 m... περισσότερα »
Calorie Estimation in Adults Differing in Body Weight Class and Weight Loss Status
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Ability to accurately estimate calories is important for weight management, yet few studies have investigated whether individuals can accurately estimate calories during exercise or in a meal. The objective of this study was to determine if accuracy of estimation of moderate or vigorous exercise energy expenditure and calories in food is associated with body weight class or weight loss status. Methods: Fifty-eight adults who were either normal weight (NW) or overweight (OW), and either attempting (WL) or not attempting weight loss (noWL), exercised on a treadm... περισσότερα »
Myokine Expression in Muscle and Myotubes in Response to Exercise Stimulation
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Myokines have been shown to affect muscle physiology and exert systemic effects. We endeavored to investigate a panel of myokine mRNA expression after a single exercise bout (studies 1 and 2) to measure myokine mRNA in primary human myotubes in an in vitro exercise model (study 2). Methods: Vastus lateralis muscle biopsies were obtained from 20 healthy males (age, 24.0 ± 4.5 yr; BMI, 23.6 ± 1.8 kg·m−2) before and after a single exercise bout (650 kcal at 50% V˙O2max). Primary myotubes from active and sedentary male donors were treated with a pharmacological co... περισσότερα »
Tear Fluid SIgA as a Noninvasive Biomarker of Mucosal Immunity and Common Cold Risk
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Research has not convincingly demonstrated the utility of saliva secretory immunoglobulin-A (SIgA) as a biomarker of upper respiratory tract infection (URTI) risk, and disagreement exists about the influence of heavy exercise ("open-window theory") and dehydration on saliva SIgA. Prompted by the search for viable alternatives, we compared the utility of tear and saliva SIgA to predict URTI prospectively (study 1) and assessed the influence of exercise (study 2) and dehydration (study 3) using a repeated-measures crossover design. Methods: In study 1, 40 subjec... περισσότερα »
Peripheral and Central Fatigue Development during All-Out Repeated Cycling Sprints
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: We investigated the development and recovery of peripheral and central fatigue during repeated cycling sprints and its influence on power output. Methods: On six separate days, 12 healthy males performed the following tests: 1, 4, 6, 8, and 10 × 10 s sprints with 30 s of passive recovery between sprints, as well as 8 × 10 s sprints with 10 s of passive recovery. Peripheral and central fatigue levels were quantified via changes in preexercise- to postexercise-potentiated quadriceps twitch force, as evoked by supramaximal electrical stimulation of the femoral ne... περισσότερα »
Biceps Femoris Architecture and Strength in Athletes with a Previous Anterior Cruciate Ligament Reconstruction
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: This study aimed to determine whether limbs with a history of anterior cruciate ligament (ACL) injury reconstructed from the semitendinosus display different biceps femoris long head (BFlh) architecture and eccentric strength, assessed during the Nordic hamstring exercise, compared with the contralateral uninjured limb. Methods: The architectural characteristics of the BFlh were assessed at rest and at 25% of a maximal voluntary isometric contraction (MVIC) in the control group (n = 52) and in the group who had previous ACL injury (n = 15) using two-dimensiona...περισσότερα »
High-Intensity Running and Energy Restriction Reduce Postprandial Lipemia in Girls
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: This study examined the potency of combining acute high-intensity exercise and energy intake restriction on postprandial triacylglycerol concentrations ([TAG]) in healthy girls. Methods: Sixteen 11- to 13-yr-old girls (mean (SD) body mass, 45.1 (7.6) kg; peak oxygen uptake (V˙O2), 43 (6) mL·kg−1·min−1) completed three 2-d conditions in a counterbalanced crossover design separated by 14 d. On day 1, participants completed 10 × 1-min interval runs (HIIR) or 5 × 1-min interval runs combined with 0.82 (0.19) MJ energy intake restriction (HIIR-ER) or rested (CON). ... περισσότερα »
Muscle Characteristics and Substrate Energetics in Lifelong Endurance Athletes
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: The goal of this study was to explore the effect of lifelong aerobic exercise (i.e., chronic training) on skeletal muscle substrate stores (intramyocellular triglyceride [IMTG] and glycogen), skeletal muscle phenotypes, and oxidative capacity (ox), in older endurance-trained master athletes (OA) compared with noncompetitive recreational younger (YA) athletes matched by frequency and mode of training. Methods: Thirteen OA (64.8 ± 4.9 yr) exercising 5 times per week or more were compared with 14 YA (27.8 ± 4.9 yr) males and females. IMTG, glycogen, fiber types, ... περισσότερα »
Appetite and Energy Intake Responses to Acute Energy Deficits in Females versus Males
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: To explore whether compensatory responses to acute energy deficits induced by exercise or diet differ by sex. Methods: In experiment one, 12 healthy women completed three 9-h trials (control, exercise-induced (Ex-Def) and food restriction–induced energy deficit (Food-Def)) with identical energy deficits being imposed in the Ex-Def (90-min run, ∼70% of V˙O2max) and Food-Def trials. In experiment two, 10 men and 10 women completed two 7-h trials (control and exercise). Sixty minutes of running (∼70% of V˙O2max) was performed at the beginning of the exercise tria... περισσότερα »
Comparison of Three Popular Exercise Modalities on V˙O2max in Overweight and Obese
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Introduction: In this prospective randomized trial, we examined the effect of three popular exercise training modalities on maximal oxygen uptake (V˙O2max) in overweight and obese individuals. In addition, we examined possible concomitant adaptations in endurance exercise performance (time to exhaustion (TTE)), citrate synthase (CS) activity, venous and arterial function, blood volume, and calculated stroke volume (SV). Methods: Thirty subjects were recruited (age, 41 ± 9 yr; weight, 91 ± 14 kg; height, 173 ± 8 cm; body mass index, 30 ± 4 kg·m−2) and randomized to eith... περισσότερα »
Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: image]Purpose: Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of time spent in moderate-to-vigorous physical activity (MVPA). Methods: Community-based men and women (n = 8623, 48–92 yr old) in the European Prospective Investigation of Cancer—Norfolk study attended a health examination for objective measurement of physical capability, including grip strength (Smedley dynamometer (kg)), usual walking speed (UWS (cm·s−1)), and time...περισσότερα »
Role of Endoscopic Skull Base and Keyhole Surgery for Pituitary and Parasellar Tumors Impacting Vision: Erratum
No abstract available from Neurology via xlomafota13 on Inoreader http://ift.tt/212eH7L via IFTTT
Lambert–Eaton Myasthenic Syndrome: Ocular Signs and Symptoms
Background: To evaluate ocular signs and symptoms in Lambert–Eaton myasthenic syndrome (LEMS) and determine the frequency of ophthalmic involvement. Methods: A retrospective review of the medical records of all patients diagnosed with LEMS at the Mayo Clinic in Rochester, MN, from January, 1976, to December, 2010, was performed with special attention to ophthalmic symptoms and signs. Results: One hundred seventy-six patients met the inclusion criteria. Ophthalmic symptoms included ptosis in 41 (23%), diplopia in 36 (20.5%), decreased vision in 24 (14%), and dry eye complaints in 12 ... περισσότερα »
Chronic Myelogenous Leukemia Relapse Presenting With Central Nervous System Blast Crisis and Bilateral Optic Nerve Infiltration
[image: image]Abstract: Bilateral, simultaneous optic nerve sheath infiltration as a manifestation of leukemia relapse is very rare. A 45-year-old woman with chronic myelogenous leukemia was successfully treated to cytogenetic bone marrow remission 1 year previously and maintained on imatinib. She developed total bilateral blindness with marked, bilateral optic disc edema and evidence of bilateral optic nerve infiltration on magnetic resonance imaging. Cerebrospinal fluid cytology confirmed central nervous system (CNS) blast crisis. She recovered visual acuity of 20/20 in the right ... περισσότερα »
Neuro-Ophthalmic Syndromes and Processing Speed in Multiple Sclerosis
[image: image]Abstract: The impact of prior neuro-ophthalmic syndromes on the performance on vision-based neuropsychological tasks in patients with multiple sclerosis (MS) is unknown. Two groups of MS participants, one with (Msos+) and the other without (Msos−), a history of neuro-ophthalmic syndromes, underwent neuropsychological assessment and were compared with healthy age- and education-matched controls (HC). Participants with Msos+ performed significantly worse on the symbol digit modalities test than the Msos− (P from Neurology via xlomafota13 on Inoreader http://ift.tt/1TpIuk... περισσότερα »
Does Treatment of Ocular Myasthenia Gravis With Early Immunosuppressive Therapy Prevent Secondarily Generalization and Should It Be Offered to All Such Patients?
No abstract available from Neurology via xlomafota13 on Inoreader http://ift.tt/1TpIu4b via IFTTT
Relationship Between Age, Gender, and Race in Patients Presenting With Myasthenia Gravis With Only Ocular Manifestations
[image: image]Background: The demographic associations among patients presenting with myasthenia gravis with only ocular manifestations (OMG) is not clear. Methods: In this 5-center case series, we collected the race, gender, and age at diagnosis of patients diagnosed with myasthenia gravis who had no signs or symptoms of generalized myasthenia gravis (GMG). An a priori sample size calculation determined that 140 patients were required to accept that there was a ≤10-year difference in mean age (equivalence testing: power 90%, α = 0.05). Robust Bayesian analysis and linear regression...περισσότερα »
What Do We Really Know About Translaminar Pressure?
No abstract available from Neurology via xlomafota13 on Inoreader http://ift.tt/1TpIqS3 via IFTTT
An Evaluation of Educational Neurological Eye Movement Disorder Videos Posted on Internet Video Sharing Sites
[image: image]Background: Internet video sharing sites allow the free dissemination of educational material. This study investigated the quality and educational content of videos of eye movement disorders posted on such sites. Methods: Educational neurological eye movement videos were identified by entering the titles of the eye movement abnormality into the search boxes of the video sharing sites. Also, suggested links were followed from each video. The number of views, likes, and dislikes for each video were recorded. The videos were then rated for their picture and sound quality....περισσότερα »
Handbook of Neuroimaging for the Ophthalmologist
[image: image]No abstract available from Neurology via xlomafota13 on Inoreader http://ift.tt/1TpIqBD via IFTTT
Cigarette Smoking and Activities of Daily Living in Ocular Myasthenia Gravis
[image: image]Background: Myasthenia gravis is an autoimmune disease of the neuromuscular junction, commonly affecting the ocular muscles. Cigarette smoking has been shown to influence many autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, but its effect on myasthenia gravis has not been well studied. We sought to determine whether cigarette smoking influenced disease-related symptoms in ocular myasthenia gravis (OMG). Methods: We performed a prospective, clinic-based cross-sectional study in a single academic neuro-ophthalmology practice. All patients diag... περισσότερα »
Optic Nerve Sheath Melanoma Presenting as a Central Retinal Vein Occlusion
[image: image]Abstract: A 64-year-old woman, with a history of diabetes and melanoma, developed a central retinal vein occlusion (CRVO) in her left eye. On exam, she had severe disc edema with retinal nerve fiber layer thickening, and anterior deformation of the peripapillary retinal pigment epithelium (RPE)/Bruch membrane layer (ppRPE/BM) toward the vitreous on spectral domain optical coherence tomography (SD-OCT) suggesting an optic nerve sheath (ONS) meningioma. Magnetic resonance imaging findings and ONS biopsy later confirmed a metastatic melanoma. This case demonstrates that t...περισσότερα »
Peripapillary Retinal Nerve Fiber Layer Thickness Corresponds to Drusen Location and Extent of Visual Field Defects in Superficial and Buried Optic Disc Drusen
[image: image]Background: Optic disc drusen (ODD) are hyaline deposits located within the optic nerve head. Peripapillary retinal nerve fiber layer (RNFL) thinning is associated with the high prevalence of visual field defects seen in ODD patients. The goal of this study was to investigate the characteristics of patients with ODD and to compare the peripapillary RNFL thickness to the extent of visual field defects and anatomic location (superficial or buried) of ODD. Methods: Retrospective, cross sectional study. Results: A total of 149 eyes of 84 ODD patients were evaluated. Sixty-... περισσότερα »
Transvenous Embolization in Pediatric Plexiform Arteriovenous Malformations
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: Transvenous embolization is a developing concept for curative therapy of cerebral arteriovenous malformations (AVMs). The feasibility of this endovascular method has not been reported in children. OBJECTIVE: To report our experience treating pediatric AVMs with the transvenous approach (TVA). METHODS: A cohort of 7 pediatric patients (younger than 18 years of age) who underwent […]
Primary Leptomeningeal Gliomatosis in Children and Adults: A Morphological and Molecular Comparative Study With Literature Review
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: Primary leptomeningeal gliomatosis (PLG) is a poorly recognized tumor of the central nervous system. OBJECTIVE: To describe the histopathological, immunohistochemical, and molecular features of PLG. METHODS: Results of our multicentric retrospective study of 6 PLG cases (3 pediatric and 3 adult) were compared with literature data. RESULTS: The mean age was 54.7 years for […]
Book Review: Atlas of the Facial Nerve and Related Structures
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1VrsvBJ via IFTTT
Can We Rely on Susceptibility-Weighted Imaging for Subthalamic Nucleus Identification in Deep Brain Stimulation Surgery?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: Susceptibility-weighted imaging (SWI) offers significantly improved visibility of the subthalamic nucleus (STN) compared with traditional T2-weighted imaging. However, it is unknown whether the representation of the nucleus on SWI corresponds to the neurophysiological location of the STN. OBJECTIVE: To determine the correlation between the intraoperative electrophysiological activity of the STN and the representation of […]
Letter: Industry Sponsorship of Spine Device Trials Is the Norm
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1UbHS30 via IFTTT
Is Intracranial Pressure Monitoring of Patients With Diffuse Traumatic Brain Injury Valuable? An Observational Multicenter Study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: Although intracranial pressure (ICP) monitoring of patients with severe traumatic brain injury (TBI) is recommended by the Brain Trauma Foundation, any benefits remain controversial. OBJECTIVE: To evaluate the effects of ICP monitoring on the mortality of and functional outcomes in patients with severe diffuse TBI. METHODS: Data were collected on patients with severe diffuse […]
Operative Neurosurgery: The Surgeon’s Armamentarium
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1UbGgGv via IFTTT
Suprasellar Arachnoid Cysts: Toward a New Simple Classification Based on Prognosis and Treatment Modality
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: Suprasellar arachnoid cysts (SAC) represent between 9% and 21% of pediatric arachnoid cysts. Recent improvements in magnetic resonance imaging, as well as increasing prenatal diagnosis, have allowed more precise knowledge and follow-up. OBJECTIVE: To describe a novel classification of SAC. METHODS: We present 35 cases of SAC treated between 1996 and 2014. Patient records […]
Heterotopic Mucosal Grafting Enables the Delivery of Therapeutic Neuropeptides Across the Blood Brain Barrier
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 47 δευτερόλεπτα
BACKGROUND: The blood-brain barrier represents a fundamental limitation in treating neurological disease because it prevents all neuropeptides from reaching the central nervous system (CNS). Currently, there is no efficient method to permanently bypass the blood-brain barrier. OBJECTIVE: To test the feasibility of using nasal mucosal graft reconstruction of arachnoid defects to deliver glial-derived neurotrophic factor […]
Conformational Disorder in the Most Immature SOD1 Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Misfolding of Cu,Zn-superoxide dismutase (SOD1) is a pathological change in the familial form of amyotrophic lateral sclerosis caused by mutations in the SOD1 gene. SOD1 is an enzyme that matures through the binding of copper and zinc ions and the formation of an intramolecular disulfide bond. Pathogenic mutations are proposed to retard the post-translational maturation, […]
Adverse Cardiac Remodeling in Myozap-/- Mice Signal Transduction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
The intercalated disc (ID) is a “hot spot” for heart disease, as several ID proteins have been found mutated in cardiomyopathy. Myozap is a recent addition to the list of ID proteins and has been implicated in serum-response factor signaling. To elucidate the cardiac consequences of targeted deletion of myozap in vivo, we generated myozap-null […]
Red-shifted Chloride Channelrhodopsin Membrane Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Chloride conducting channelrhodopsins (ChloCs) are new members of the optogenetic toolbox that enable neuronal inhibition in target cells. Originally, ChloCs have been engineered from cation conducting channelrhodopsins (ChRs), and later identified in a cryptophyte alga genome. We noticed that the sequence of a previously described Proteomonas sulcata ChR (PsChR1) was highly homologous to the naturally […]
Icsbp Terminates Emergency Granulopoiesis Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Emergency granulopoiesis occurs in response to infectious or inflammatory challenge and is a component of the innate immune response. Some molecular events involved in initiating emergency granulopoiesis are known, but termination of this process is less well defined. In this study, we found that the interferon consensus sequence binding protein (Icsbp/Irf8) was required to terminate […]
Hyaluronan in Fibroblast-Cancer Cell Interaction Glycobiology and Extracellular Matrices
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
The aim of this study was to characterize the interaction of KYSE-410, an esophageal squamous cell carcinoma cell line, and fibroblasts with respect to the extracellular matrix component hyaluronan (HA) and chemokine expression. KYSE-410 cells induced the mRNA expression of HA synthase 2 (Has2) in normal skin fibroblasts (SF) only in direct co-cultures. Parallel to […]
Small Molecules in Thyroiditis Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that blocking the binding of these peptides to DRβ1-Arg74 could block […]
Allosteric Regulation of Cyclooxygenases by Fatty Acids Enzymology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Prostaglandin endoperoxide H synthases (PGHSs), also called cyclooxygenases (COXs), convert arachidonic acid (AA) to PGH2. PGHS-1 and PGHS-2 are conformational heterodimers, each composed of an (Eallo) and a catalytic (Ecat) monomer. Previous studies suggested that the binding to Eallo of saturated or monounsaturated fatty acids (FAs) that are not COX substrates differentially regulate PGHS-1 versus […]
Condensation and Assembly of Metastable Reflectin Proteins Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Reversible changes in the phosphorylation of reflectin proteins have been shown to drive the tunability of color and brightness of light reflected from specialized cells in the skin of squids and related cephalopods. We show here, using dynamic light scattering, electron microscopy, and fluorescence analyses, that reversible titration of the excess positive charges of the […]
Knowledge and uptake of genetic counseling and colonoscopic screening among individuals at increased risk for Lynch syndrome and their endoscopists from the family health promotion project
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 52 δευτερόλεπτα
The American Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QNrrnY via IFTTT
Viral hepatitis B and C outbreak related to parenteral treatment at an oncological department in Slovakia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 52 δευτερόλεπτα
Journal of Hospital Infection from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QNrrnP via IFTTT
A phase I study of folfirinox plus IPI-926, a Hedgehog pathway inhibitor, for advanced pancreatic adenocarcinoma
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 52 δευτερόλεπτα
Pancreas from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QNros9 via IFTTT
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours.
Objective: To determine whether exaggerating the variations in fundamental frequency (F0) contours of Mandarin-based pitch fluctuations could improve tone identification by cochlear implant (CI) users. Methods: Twelve normal-hearing (NH) listeners and 11 CI users were tested for their ability to recognize F0 contours modeled after Mandarin tones, in 4- or 5-alternatives forced-choice paradigms. Two types of stimuli were used: computer-generated complex tones and voice recordings. Four contours were tested with voice recordings: flat, rise, fall, and dip. A fifth contour, peak, was a... περισσότερα »
"Physiological" Ear Clicking: Its Origin and Potential Usability as a Test Tool for the Eustachian Tube Function.
Objective: To explore the origin of "physiological" ear clicks during deglutition or other pharyngeal movements, which, in contrast to disturbing frequent clicks under pathologic conditions, mostly remain unnoticed by the patient. Study Design: Clinical experimental study at a tertiary referral center. Methods: Ear clicks were recorded by a microphone sealing the external ear canal parallel to endoscopic or manometric evaluations of the Eustachian tube function. Results: Obviously, the acoustic signals (clicks) appear when the tube opens. The clicks might be explained by a disruption... περισσότερα »
Parenteral Nutrition of Preterm Infants May Lead to Inadequate Phosphorus Supply.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
No abstract available from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1PVDLCL via IFTTT
Golimumab Therapy in Six Patients with Severe Pediatric Onset Crohn's Disease.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Anti-TNF[alpha] blockade is so far the most effective therapy for extensive pediatric Crohn[Combining Acute Accent]s disease (CD), but loss of response is frequently encountered. We describe here the use of golimumab (Simponi) in six pediatric CD patients with antibody formation/loss of response to infliximab and adalimumab. Most patients had undergone surgery but had poor disease control. After introduction of golimumab, the levels of inflammatory markers and fecal calprotectin declined at first, but the response was not sustained. Each patient needed dose escalation of golimumab f...περισσότερα »
Mucosal Healing of Pediatric Simple Ulcer Treated with Infliximab and Methotrexate.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
No abstract available from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1UbJv0z via IFTTT
Hepatoblastoma in Explanted Livers of Patients with Biliary Atresia.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Objectives: Surveillance of hepatic nodules for malignant transformation to hepatocellular carcinoma is important in the monitoring of patients with Biliary Atresia (BA). To-date, only two published case reports describe the finding of Hepatoblastoma (HB) in this setting. This study aimed to investigate this association of HB and BA, and to assess the utility of alpha-fetoprotein (aFP) as a marker in the diagnosis. Methods: A retrospective study of all patients who underwent isolated liver transplantation (LTx) for the primary diagnosis of BA at a single center, between January 1999... περισσότερα »
Quality of Reporting Nutritional Randomized Controlled Trials in Patients with Cystic Fibrosis.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Background: Randomized controlled trials (RCTs) have a major role in the making of evidence-based guidelines. We aimed to critically appraise the RCTs that addressed nutritional interventions in Cystic Fibrosis (CF) patients. Materials and Methods: Embase, PubMed and the Cochrane Library were systematically searched until July 2015. Methodology and reporting of nutritional RCTs were evaluated by the CONSORT checklist and additional dimensions relevant to CF patients. Results: 51 RCTs were included. Full details on methods were provided in a minority of studies. The mean duration of ...περισσότερα »
Value of Gamma-Glutamyl Transpeptidase for Diagnosis of Biliary Atresia by Correlation with Age.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Objectives: Study the value of gamma-glutamyl transpeptidase (GGT) for distinguishing biliary atresia (BA) from non-BA for patients suspected of having neonatal obstructive jaundice (NOJ) by correlation with age. Methods: From January 2003 to March 2014, cholangiography and/or surgical exploration were undertaken in 1469 patients with suspicion of having NOJ. A total of 1338 patients were diagnosed with BA intraoperatively. Preoperative medical records were compared between BA and non-BA patients. Results: Preoperative levels of total bilirubin (TB), direct bilirubin (DB) and GGT we... περισσότερα »
Icsbp Terminates Emergency Granulopoiesis Molecular Bases of Disease
Emergency granulopoiesis occurs in response to infectious or inflammatory challenge and is a component of the innate immune response. Some molecular events involved in initiating emergency granulopoiesis are known, but termination of this process is less well defined. In this study, we found that the interferon consensus sequence binding protein (Icsbp/Irf8) was required to terminate… Continue reading Icsbp Terminates Emergency Granulopoiesis Molecular Bases of Disease
Hyaluronan in Fibroblast-Cancer Cell Interaction Glycobiology and Extracellular Matrices
The aim of this study was to characterize the interaction of KYSE-410, an esophageal squamous cell carcinoma cell line, and fibroblasts with respect to the extracellular matrix component hyaluronan (HA) and chemokine expression. KYSE-410 cells induced the mRNA expression of HA synthase 2 (Has2) in normal skin fibroblasts (SF) only in direct co-cultures. Parallel to… Continue reading Hyaluronan in Fibroblast-Cancer Cell Interaction Glycobiology and Extracellular Matrices
Small Molecules in Thyroiditis Molecular Bases of Disease
We previously showed that an HLA-DR variant containing arginine at position 74 of the DRβ1 chain (DRβ1-Arg74) is the specific HLA class II variant conferring risk for autoimmune thyroid diseases (AITD). We also identified 5 thyroglobulin (Tg) peptides that bound to DRβ1-Arg74. We hypothesized that blocking the binding of these peptides to DRβ1-Arg74 could block… Continue reading Small Molecules in Thyroiditis Molecular Bases of Disease
Condensation and Assembly of Metastable Reflectin Proteins Cell Biology
Reversible changes in the phosphorylation of reflectin proteins have been shown to drive the tunability of color and brightness of light reflected from specialized cells in the skin of squids and related cephalopods. We show here, using dynamic light scattering, electron microscopy, and fluorescence analyses, that reversible titration of the excess positive charges of the… Continue reading Condensation and Assembly of Metastable Reflectin Proteins Cell Biology
Allosteric Regulation of Cyclooxygenases by Fatty Acids Enzymology
Prostaglandin endoperoxide H synthases (PGHSs), also called cyclooxygenases (COXs), convert arachidonic acid (AA) to PGH2. PGHS-1 and PGHS-2 are conformational heterodimers, each composed of an (Eallo) and a catalytic (Ecat) monomer. Previous studies suggested that the binding to Eallo of saturated or monounsaturated fatty acids (FAs) that are not COX substrates differentially regulate PGHS-1 versus… Continue reading Allosteric Regulation of Cyclooxygenases by Fatty Acids Enzymology
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia HEAD & NECK
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
SUMMARY: Neurovascular compression syndromes are usually caused by arteries that directly contact the cisternal portion of a cranial nerve. Not all cases of neurovascular contact are clinically symptomatic. The transition zone between the central and peripheral myelin is the most vulnerable region for symptomatic neurovascular compression syndromes. Trigeminal neuralgia (cranial nerve V) has an incidence […]
C-Arm Conebeam CT Perfusion Imaging in the Angiographic Suite: A Comparison with Multidetector CT Perfusion Imaging ADULT BRAIN
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND PURPOSE: Perfusion imaging in the angiography suite may provide a way to reduce time from stroke onset to endovascular revascularization of patients with large-vessel occlusion. Our purpose was to compare conebeam CT perfusion with multidetector CT perfusion. MATERIALS AND METHODS: Data from 7 subjects with both multidetector CT perfusion and conebeam CT perfusion […]
Computer-Assisted Detection of Cerebral Aneurysms in MR Angiography in a Routine Image-Reading Environment: Effects on Diagnosis by Radiologists ADULT BRAIN
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND PURPOSE: Experiences with computer-assisted detection of cerebral aneurysms in diagnosis by radiologists in real-life clinical environments have not been reported. The purpose of this study was to evaluate the usefulness of computer-assisted detection in a routine reading environment. MATERIALS AND METHODS: During 39 months in a routine clinical practice environment, 2701 MR angiograms […]
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia HEAD & NECK
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
SUMMARY: Neurovascular compression syndromes are usually caused by arteries that directly contact the cisternal portion of a cranial nerve. Not all cases of neurovascular contact are clinically symptomatic. The transition zone between the central and peripheral myelin is the most vulnerable region for symptomatic neurovascular compression syndromes. Trigeminal neuralgia (cranial nerve V) has an incidence […]
Inflow Jet Patterns of Unruptured Cerebral Aneurysms Based on the Flow Velocity in the Parent Artery: Evaluation Using 4D Flow MRI INTERVENTIONAL
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND PURPOSE: Inflow jet characteristics may be related to aneurysmal bleb formation and rupture. We investigated the visualization threshold on the basis of the flow velocity in the parent artery to classify the inflow jet patterns observed on 4D flow MR imaging. MATERIALS AND METHODS: Fifty-seven unruptured aneurysms (24 bifurcation and 33 sidewall aneurysms) […]
Computer-Assisted Detection of Cerebral Aneurysms in MR Angiography in a Routine Image-Reading Environment: Effects on Diagnosis by Radiologists ADULT BRAIN
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
BACKGROUND AND PURPOSE: Experiences with computer-assisted detection of cerebral aneurysms in diagnosis by radiologists in real-life clinical environments have not been reported. The purpose of this study was to evaluate the usefulness of computer-assisted detection in a routine reading environment. MATERIALS AND METHODS: During 39 months in a routine clinical practice environment, 2701 MR angiograms […]
Early weaning is beneficial to prevent atopic dermatitis occurrence in young children
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Epidemiological data on infant feeding practices and allergic diseases are controversial. The purpose of this study was to explore the association of early weaning with the occurrence of atopic dermatitis (AD). Methods We conducted a matched case-control study on incident physician-diagnosed AD in early childhood including 451 cases and 451 controls. Data on […]
Changes in Parent-Child Relationship Quality Across Early Adolescence:: Implications for Engagement in Sexual Behavior
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The present study investigated how changes in specific dimensions of the parent–adolescent relationship predict adolescent engagement in sexual intercourse and oral sex. Longitudinal data from 1,364 participants in the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development were gathered at six time points spanning from first […]
Is Emtricitabine-Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection Safer Than Aspirin?
*Background.* The safety and effectiveness studies of emtricitabine-tenofovir disoproxil fumarate (FTC-TDF) for human immunodeficiency virus (HIV) infection pre-exposure prophylaxis (PrEP) in men and women showed that daily use reduced the risk of HIV acquisition, but there still may concerns about safety. *Methods.* A narrative review was done in September 2015 comparing the 5 major studies on PrEP for HIV infection—Preexposure Prophylaxis Initiative (N = 2499; 3324 person-years), Partners Preexposure Prophylaxis (N = 4747; 7830 person-years), TDF2 (N = 1219; 1563 person-years), ...περισσότερα »
What are the Physiological Mechanisms for Post-Exercise Cold Water Immersion in the Recovery from Prolonged Endurance and Intermittent Exercise?
Abstract Intense training results in numerous physiological perturbations such as muscle damage, hyperthermia, dehydration and glycogen depletion. Insufficient/untimely restoration of these physiological alterations might result in sub-optimal performance during subsequent training sessions, while chronic imbalance between training stress and recovery might lead to overreaching or overtraining syndrome. The use of post-exercise cold water immersion (CWI) is gaining considerable popularity among athletes to minimize fatigue and accelerate post-exercise recovery. CWI, through its pri...περισσότερα »
Erratum to: Effect of Training Leading to Repetition Failure on Muscular Strength: A Systematic Review and Meta-Analysis
from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VpNxRd via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TpN2Yk via IFTTT
Bringing Nature to Schools to Promote Children’s Physical Activity
Abstract Physical activity (PA) is essential for human health and wellbeing across all age, socioeconomic, and ethnic groups. Engagement with the natural world is a new defining criterion for enhancing the benefits of PA, particularly for children and young people. Interacting with nature benefits children’s social and emotional wellbeing, develops resilience, and reduces the risk of obesity and type 2 diabetes mellitus across all population groups. Governments around the world are now recognizing the importance of children spending more active time outdoors. However, children’s ou... περισσότερα »
Monitoring Athletic Training Status Through Autonomic Heart Rate Regulation: A Systematic Review and Meta-Analysis
AbstractBackground Autonomic regulation of heart rate (HR) as an indicator of the body’s ability to adapt to an exercise stimulus has been evaluated in many studies through HR variability (HRV) and post-exercise HR recovery (HRR). Recently, HR acceleration has also been investigated. Objective The aim of this systematic literature review and meta-analysis was to evaluate the effect of negative adaptations to endurance training (i.e., a period of overreaching leading to attenuated performance) and positive adaptations (i.e., training leading to improved performance) on autonomic HR ... περισσότερα »
Ageing, Muscle Power and Physical Function: A Systematic Review and Implications for Pragmatic Training Interventions
AbstractBackground The physiological impairments most strongly associated with functional performance in older people are logically the most efficient therapeutic targets for exercise training interventions aimed at improving function and maintaining independence in later life. Objectives The objectives of this review were to (1) systematically review the relationship between muscle power and functional performance in older people; (2) systematically review the effect of power training (PT) interventions on functional performance in older people; and (3) identify components of succ... περισσότερα »
Association between sleep disorders and injury: a nationwide population-based retrospective cohort study
Background The evidence is insufficient for the association between the exposure of sleep disorders and the risk of injury. The aim of this study was to examine the association between patients with sleep disorders and the risk of injury. Methods This was a population-based retrospective cohort study using Taiwan National Health Insurance Research Database from 2005 to 2010. A total of 15 109 patients with sleep disorders were identified as the study cohort. The non-sleep disorders control cohort comprised 29 955 age- and sex-matched patients. We conducted a Cox proportional haz... περισσότερα »
Acute care surgery and emergency general surgery
Acute care surgery and emergency general surgery: Addition by subtraction.: Introduction: The formation of Acute Care Surgery (ACS) leads to decreased time to treatment and improved outcomes for emergency general surgery (EGS) patients. However, minimal work has focused on the ideal care delivery system and team structure. We hypothesize that the implementation of a dedicated EGS team (separate from trauma and surgical critical care), with EGS-specific protocols and dedicated operating room (OR) time, will increase productivity and improve mortality. Methods: This is a retrospective...περισσότερα »
Assessment of lifesaving traumatic hemorrhage and airway management skills.
Feasibility of a perfused and ventilated cadaveric model for assessment of lifesaving traumatic hemorrhage and airway management skills.: Background: Training healthcare providers to manage common life-threatening traumatic injuries is an important endeavor. A fresh perfused cadaveric model with high anatomic and tissue fidelity was developed in order to assess performance of hemorrhage and airway management skills during a simulated polytrauma scenario. Methods: Fresh human cadavers were obtained within 96 hours of death. Hemorrhage from a right traumatic amputation and left inguin...περισσότερα »
Randomized controlled trial comparing dynamic simulation to static simulation in trauma.
Randomized controlled trial comparing dynamic simulation to static simulation in trauma.: Introduction: Current general surgery residents have limited exposure to open trauma operative cases. Simulation supplements variable rotation volume and provides experience with critical but rarely performed procedures. Open simulation classically focuses on static models with anatomic accuracy, but lacks practicality when hemorrhage control is the life-saving maneuver. We sought to evaluate whether training on a dynamic simulator, while much less expensive than training on a static cadaver, m... περισσότερα »
Diagnosis and Treatment of Ventilator-Associated Infection
Diagnosis and Treatment of Ventilator-Associated Infection: Review of the Critical Illness Stress-Induced Immune Suppression Prevention Trial Data.: Objectives: The Critical Illness Stress-Induced Immune Suppression prevention trial was a randomized, masked trial of zinc, selenium, glutamine, and metoclopramide compared with whey protein in delaying nosocomial infection in PICU patients. One fourth of study subjects were diagnosed with nosocomial lower respiratory infection, which contributed to subjects receiving antibiotics 74% of all patient days in the PICU. We analyzed diagnosti...περισσότερα »
Optimal Chest Compression Position for Patients With a Single Ventricle During Cardiopulmonary Resuscitation.
Optimal Chest Compression Position for Patients With a Single Ventricle During Cardiopulmonary Resuscitation.: Objectives: Few studies have examined cardiopulmonary resuscitation for patients with congenital heart disease, although they are at a high risk of cardiac arrest. Therefore, this study investigated the optimal chest compression position in patients with a single ventricle while providing them with basic life support. Design: This is a retrospective study of patients with a single ventricle who are undergoing chest CT. Setting: Tertiary teaching children's hospital. Patien... περισσότερα »
Facial Mimicry and Emotion Perception in Unilateral Facial Paralysis
*Facial Mimicry and Emotion Perception in Unilateral Facial Paralysis: This study evaluates the effects of unilateral facial paralysis on the recognition of and judgments about facial expressions of emotion.* *Importance The ability of patients with unilateral facial paralysis to recognize and appropriately judge facial expressions remains underexplored.* *Objective To test the effects of unilateral facial paralysis on the recognition of and judgments about facial expressions of emotion and to evaluate the asymmetry of facial mimicry.* *Design, Setting, and Participants Pa... περισσότερα »
Novel movement disorder society–Parkinson's disease criteria: What about SWEDD and genetic forms?
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Erk5 and P38 Kinase are Positive Regulators of Insulin and Tnfα – Stimulated Vcam-1 Expression in Rat Aorta Endothelial Cells
The post Erk5 and P38 Kinase are Positive Regulators of Insulin and Tnfα – Stimulated Vcam-1 Expression in Rat Aorta Endothelial Cells appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mLqVPi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RSXSGy via IFTTT
Enduring Egalitarianism? Family Transitions and Attitudes Toward Gender Equality in Sweden
Previous research in industrialized countries finds that attitudes toward gender equality are affected by family-related transitions as young adults with egalitarian attitudes based on growing equality between the sexes in the public sphere of education and work encounter a much less equal situation in the private sphere of the family. Sweden, however, is a society known for its emphasis on gender equality in the family. This study examines the effect of family transitions on attitudes toward gender equality, asking whether egalitarian attitudes can withstand changing family trans... περισσότερα »
MicroRNA-124 Suppresses Tumor Cell Proliferation and Invasion by Targeting CD164 Signaling Pathway in Non-Small Cell Lung Cancer
The post MicroRNA-124 Suppresses Tumor Cell Proliferation and Invasion by Targeting CD164 Signaling Pathway in Non-Small Cell Lung Cancer appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mLqVPg via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RSXVlz via IFTTT
Pioglitazone may reduce cardiovascular events in high risk patients with prediabetes
Pioglitazone, an insulin sensitising agent, may reduce the risk of myocardial infarction (MI) and stroke after a recent transient ischaemic attack (TIA) or stroke in patients without diabetes who are... [image: recent?d=yIl2AUoC8zA] [image: recent?d=dnMXMwOfBR0] [image: recent?i=_Ptoq3qQAFk:UYUm9Fh89T0:V_sGLiP] [image: recent?d=qj6IDK7rITs] [image: recent?i=_Ptoq3qQAFk:UYUm9Fh89T0:gIN9vFw] [image: recent?d=l6gmwiTKsz0] [image: recent?d=7Q72WNTAKBA] [image: recent?i=_Ptoq3qQAFk:UYUm9Fh89T0:F7zBnMy] [image: recent?i=_Ptoq3qQAFk:UYUm9Fh89T0:-BTjWOF] from #AlexandrosSfakianakis via Ale... περισσότερα »
IJERPH, Vol. 13, Pages 231: Sunbed Use Prevalence and Associated Skin Health Habits: Results of a Representative, Population-Based Survey among Austrian Residents
Recreational sunbed use accounts for the main non-solar source of exposure to ultraviolet radiation in fair-skinned Western populations. Indoor tanning is associated with increased risks for acute and chronic dermatological diseases. The current community-based study assessed the one-year prevalence of sunbed use and associated skin health habits among a representative, gender-balanced sample of 1500 Austrian citizens. Overall one-year prevalence of sunbed use was 8.9% (95% confidence interval (CI) 7.5%–10.4%), with slightly higher prevalence in females (9.2%, 95% CI 7.3%–11.2%) com...περισσότερα »
Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing [Research]
Epidemiologic evidence suggests that air pollution is a risk factor for childhood obesity. Limited experimental data have shown that early-life exposure to ambient particles either increases susceptibility to diet-induced weight gain in adulthood or increases insulin resistance, adiposity, and inflammation. However, no data have directly supported a link between air pollution and non-diet-induced weight increases. In a rodent model, we found that breathing Beijing’s highly polluted air resulted in weight gain and cardiorespiratory and metabolic dysfunction. Compared to those expos... περισσότερα »
Asthma Linked to Abdominal Aortic AneurysmAsthma Linked to Abdominal Aortic Aneurysm
Individuals with asthma face an increased risk of abdominal aortic aneurysm (AAA) and rupture, according to data from the Danish National Registry of Patients (DNRP) and the Viborg Vascular (VIVA) screening trial. Reuters Health Information (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1owdJ2z via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UbBZCW via IFTTT
Asthma vs COPD: What’s the Difference?Asthma vs COPD: What’s the Difference?
Does it matter whether patients have COPD, asthma, or features of both? Dr Aaron Holley comments on the CHAIN study. Medscape Critical Care (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21cCAWW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RbCBpp via IFTTT
1 in 4 Breast Cancer Lumpectomies Requires Follow-Up Surgery
Risk after breast-conserving operation is lower with ‘high-volume’ surgeons, researchers say (Source: The Doctors Lounge – Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RbCdqE via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RbCCJV via IFTTT
Mal de Meleda: A Focused ReviewMal de Meleda: A Focused Review
Mal de Meleda is a rare type of inherited palmoplantar keratoderma. Learn about its genetic basis, its clinical and histological features, and management approaches in this review. American Journal of Clinical Dermatology (Source: Medscape Allergy Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1owdKDw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UbC21t via IFTTT
Large-scale evaluation of in prostate cancer reveals diagnostic and prognostic biomarker potential at three molecular levels
Limitations of current diagnostic and prognostic tools for prostate cancer (PC) have led to over-diagnosis and over-treatment. Here, we investigate the biomarker potential of the SLC18A2 (VMAT2) gene for PC at three molecular levels. Thus, SLC18A2 promoter methylation was analyzed in 767 malignant and 78 benign radical prostatectomy (RP) samples using methylation-specific qPCR and Illumina 450K methylation microarray data. SLC18A2 transcript levels were assessed in 412 malignant and 45 benign RP samples using RNAseq data. (Source: Molecular Oncology) from #Medicine-SfakianakisAlex...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,February 19th,2016
Orphan drugs = smale legemidler sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα Legemidler utviklet til bruk ved sjeldne tilstander trenger et godt, norsk uttrykk. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1owkW2B via IFTTT Pioglitazone may reduce cardiovascular events in high risk patients with prediabetes sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Cret... περισσότερα »
Orphan drugs = smale legemidler
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Legemidler utviklet til bruk ved sjeldne tilstander trenger et godt, norsk uttrykk. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1owkW2B via IFTTT
Pioglitazone may reduce cardiovascular events in high risk patients with prediabetes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pioglitazone, an insulin sensitising agent, may reduce the risk of myocardial infarction (MI) and stroke after a recent transient ischaemic attack (TIA) or stroke in patients without diabetes who are… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q4KaPB via IFTTT
Feedback to GPs reduces antibiotic prescribing, study finds
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sending a letter to GPs in England who have above average antibiotic prescribing rates to give feedback on their prescribing habits reduced their antibiotic prescribing by an average of just over 3%… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q4Kaz1 via IFTTT
Enduring Egalitarianism? Family Transitions and Attitudes Toward Gender Equality in Sweden
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Previous research in industrialized countries finds that attitudes toward gender equality are affected by family-related transitions as young adults with egalitarian attitudes based on growing equality between the sexes in the public sphere of education and work encounter a much less equal situation in the private sphere of the family. Sweden, however, is a society […]
Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been shown to play a key role in the transport […]
Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Epidemiologic evidence suggests that air pollution is a risk factor for childhood obesity. Limited experimental data have shown that early-life exposure to ambient particles either increases susceptibility to diet-induced weight gain in adulthood or increases insulin resistance, adiposity, and inflammation. However, no data have directly supported a link between air pollution and non-diet-induced weight increases. […]
Specific autoantigens in experimental autoimmunity-associated atherosclerosis Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Higher cardiovascular morbidity in patients with a wide range of autoimmune diseases highlights the importance of autoimmunity in promoting atherosclerosis. Our purpose was to investigate the mechanisms of accelerated atherosclerosis and identified vascular autoantigens targeted by autoimmunity. We created a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow (BM) from FcRIIB knockout (FcRIIB–/–) mice […]
Novel movement disorder society–Parkinson’s disease criteria: What about SWEDD and genetic forms?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ow6Iie via IFTTT
Nonmotor symptoms in patients without evidence of dopaminergic deficit
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ow6GXB via IFTTT
Substantia nigra hyperechogenicity and Parkinson’s disease risk in patients with essential tremor
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Background Several studies have reported an increased risk for patients with essential tremor to develop Parkinson’s disease. In addition, hyperechogenicity in the area of the substantia nigra has been associated with a markedly increased risk for Parkinson’s disease. The objective of this study was to evaluate the validity of substantia nigra hyperechogenicity in patients […]
Epicrania Fugax: Brief paroxysms of pain describing a linear or zigzag trajectory across the surface of one hemicranium
Epicrania Fugax: AbstractEpicrania fugax (EF) is a primary headache of recent description. EF essentially consists of brief paroxysms of pain describing a linear or zigzag trajectory across the surface of one hemicranium, commencing and terminating in the territories of different nerves. The pain of forward EF originates in a particular area of the occipital, parietal or temporal regions and moves anteriorly, whereas the pain of backward EF originates in the frontal area, the eye or the nose and moves posteriorly. Some patients have ocular or nasal autonomic accompaniments, and som... περισσότερα »
Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis
Summary Background Infliximab and adalimumab have established roles in inflammatory bowel disease (IBD) therapy. UK regulators mandate reassessment after 12 months' anti-TNF therapy for IBD, with consideration of treatment withdrawal. There is a need for more data to establish the relapse rates following treatment cessation. Aim To establish outcomes following anti-TNF withdrawal for sustained remission using new data from a large UK cohort, and assimilation of all available literature for systematic review and meta-analysis. Methods A retrospective observational study was perf... περισσότερα »
Retropharyngeal Nodes in Treatment Deintensification
February 18, 2016 The Significance of Retropharyngeal Nodes in Treatment Deintensification ONLINE FIRST Christine G. Gourin, MD, MPH1 [+] Author Affiliations *JAMA Otolaryngol Head Neck Surg*. Published online February 18, 2016. doi:10.1001/jamaoto.2016.0122 Text Size: A A A Article References Comments Treatment deintensification of human papillomavirus (HPV) associated oropharyngeal squamous cell cancer (OPSCC) is a topic of active debate. It is well recognized that HPV-associated OPSCC has unique tumor biological characteristics, reflected by a high propensity for nodal involvement a... περισσότερα »
Association between direct and indirect smoking and osteoarthritis prevalence in Koreans: a cross-sectional study
Objectives To assess the association between smoking patterns and knee and hip joint osteoarthritis (OA) prevalence in Koreans aged 50 years or older with focus on knee OA. Design Cross-sectional study using nationally representative data. Setting Data were collected at portable Health Examination Centres in Korea. Participants Data of 9064 participants of the 5th Korean National Health and Nutrition Examination Survey (2010–2012) aged 50 years or older who received knee or hip joint X-rays out of 31 596 total surveyees were analysed. Primary outcome measures OA prevalence b... περισσότερα »
Is herpes zoster an additional complication in old age alongside comorbidity and multiple medications? Results of the post hoc analysis of the 12-month longitudinal prospective observational ARIZONA cohort study
Objectives To examine the burden of comorbidity, polypharmacy and herpes zoster (HZ), an infectious disease, and its main complication post-herpetic neuralgia (PHN) in young (50–70 years of age: 70–) and old (≥70 years of age: 70+) patients. Design Post hoc analysis of the results of the 12-month longitudinal prospective multicentre observational ARIZONA cohort study. Settings and participants The study took place in primary care in France from 20 November 2006 to 12 September 2008. Overall, 644 general practitioners (GPs) collected data from 1358 patients aged 50 years or mor... περισσότερα »
Hearing loss in workers exposed to epoxy adhesives and noise: a cross-sectional study
Objectives Epoxy adhesives contain organic solvents and are widely used in industry. The hazardous effects of epoxy adhesives remain unclear. The objective of this study was to investigate the risk of hearing loss among workers exposed to epoxy adhesives and noise. Design Cross-sectional study. Methods For this cross-sectional study, we recruited 182 stone workers who were exposed to both epoxy adhesives and noise, 89 stone workers who were exposed to noise only, and 43 workers from the administrative staff who had not been exposed to adhesives or noise. We obtained demographi...περισσότερα »
How often are interventions in cluster-randomised controlled trials of complex interventions in general practices effective and reasons for potential shortcomings? Protocol and results of a feasibility project for a systematic review
Introduction Most studies conducted at general practices investigate complex interventions and increasingly use cluster-randomised controlled trail (c-RCT) designs to do so. Our primary objective is to evaluate how frequently complex interventions are shown to be more, equally or less effective than routine care in c-RCTs with a superior design. The secondary aim is to discover whether the quality of a c-RCT determines the likelihood of the complex intervention being effective. Methods and analysis All c-RCTs of any design that have a patient-relevant primary outcome and with a...περισσότερα »
Factors affecting uptake of influenza vaccination among family physicians
[image: S0264410X.gif] Publication date: Available online 18 February 2016 *Source:*Vaccine Author(s): H. Akan, E. Yavuz, E. Yayla, H. Külbay, E. Altunok, O. Zahmacıoğlu, S. Badur AimThe aim of this study was to determine the factors that influenced the decisions of family physicians working in primary care health services to receive influenza vaccines.MethodsThis cross-sectional study was performed between June 2014 and September 2014. Physicians were reached electronically via e-mail. A self-reported questionnaire consisting of 50 items covering potential factors that may have inf... περισσότερα »
C, Vol. 2, Pages 6: The Kinetics of Single-Walled Carbon Nanotube Aggregation in Aqueous Media Is Sensitive to Surface Charge
Single-walled carbon nanotubes (SWCNTs) dispersed in aqueous media have many potential applications in chemistry, biology and medicine. To disperse SWCNTs into aqueous media, it is often necessary to modify the surface of SWCNTs by either covalent or noncovalent methods. As a result of this modification, the properties of SWCNTs may be profoundly influenced by the nature of the surface modification. Here, by using SWCNTs dispersed with single-stranded DNA of different lengths, we show that the kinetics of SWCNTs' aggregation in aqueous media is strongly dependent on the status of ...περισσότερα »
Entropy, Vol. 18, Pages 59: An Optimization Approach of Deriving Bounds between Entropy and Error from Joint Distribution: Case Study for Binary Classifications
In this work, we propose a new approach of deriving the bounds between entropy and error from a joint distribution through an optimization means. The specific case study is given on binary classifications. Two basic types of classification errors are investigated, namely, the Bayesian and non-Bayesian errors. The consideration of non-Bayesian errors is due to the facts that most classifiers result in non-Bayesian solutions. For both types of errors, we derive the closed-form relations between each bound and error components. When Fano's lower bound in a diagram of "Error Probabili... περισσότερα »
IJGI, Vol. 5, Pages 19: The Dual Half-Edge—A Topological Primal/Dual Data Structure and Construction Operators for Modelling and Manipulating Cell Complexes
There is an increasing need for building models that permit interior navigation, e.g., for escape route analysis. This paper presents a non-manifold Computer-Aided Design (CAD) data structure, the dual half-edge based on the Poincaré duality that expresses both the geometric representations of individual rooms and their topological relationships. Volumes and faces are expressed as vertices and edges respectively in the dual space, permitting a model just based on the storage of primal and dual vertices and edges. Attributes may be attached to all of these entities permitting, for ... περισσότερα »
The Head and Neck–Reconstructive Surgery NSQIP. The initial pilot demonstrates the ability to systematically capture head and neck surgery–specific variables with complete sampling. With multi-institutional expansion, increased accrual, and long-term patient-reported outcomes, we hope to set risk-adjusted benchmarks that may underpin quality improvement efforts in complex head and neck surgery.
The Head and Neck–Reconstructive Surgery NSQIP: This study describes the adaptation of the American College of Surgeons National Surgical Quality Improvement Program for complex head and neck oncologic surgical procedures. *Importance* The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) serves the need for continual quality assessment in general surgery. Previously, no parallel mechanism specific to head and neck oncologic surgery existed. *Objective* To address the need for continual quality assessment in subspecialty surgery by adapting t... περισσότερα »
The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)
Specialty-Specific National Surgical Quality Improvement Program: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) was started by an act of the United States Congress in an attempt to decrease excessive mortality among patients within the Veterans Health Administration system. Currently, more than 200 hospitals participate in the ACS-NSQIP system. The focus of the program has been mainly on general surgery and vascular surgery procedures. A key part of ACS-NSQIP has been the recognition of the need for adjustment for patient-specific illness...περισσότερα »
Advanced Oropharyngeal SCC : The prevalence of pathologic RPA in this cohort was 18.0%, and patients with multiple nodes had the highest risk of pathologic RPA, followed by involvement of the posterior tonsillar pillar. However, these data suggest that there is no clear algorithm that can be used for deintensification to exclude the retropharyngeal site from the treatment volume using extent of disease gathered from pretreatment imaging for patients with advanced-stage OPSCC.
Advanced Oropharyngeal Squamous Cell Carcinoma Treatment Algorithm: This study evaluates the prevalence of pathologic retropharyngeal adenopathy in oropharyngeal squamous cell carcinoma relative to involvement of the oropharyngeal subsite, number of metastatic neck nodes, T classification, and N classification. *Importance* Understanding the drainage patterns to the retropharyngeal lymph nodes is an important consideration in oropharyngeal squamous cell carcinoma (OPSCC) because treatment of these nodes is related to increased morbidity. Prediction of these drainage patterns cou...περισσότερα »
BLZ-100 is a sensitive and specific marker of HNSCC and can distinguish high-risk from low-risk dysplasia. BLZ-100 has the potential to serve as an intraoperative guide for tumor margin excision and identification of premalignant lesions.
BLZ-100 and Identification of HNSCC and High-Risk Oral Dysplasia: This study uses an orthotopic xenograft mouse model to examine BLZ-100 uptake in human HNSCC tumor xenografts and determine the sensitivity and specificity of this uptake. *Importance* Surgical cure of head and neck squamous cell carcinoma (HNSCC) remains hampered by inadequately resected tumors and poor recognition of lesions with malignant potential. BLZ-100 is a chlorotoxin-based, tumor-targeting agent that has not yet been studied in HNSCC. *Objective* To evaluate BLZ-100 uptake in models of HNSCC and oral d...περισσότερα »
New-Onset Facial Weakness After 5 Years of Facial Asymmetry
New-Onset Facial Weakness After 5 Years of Facial Asymmetry: A man presented with a 5-year progression of facial asymmetry and a 2-week history of left-sided facial weakness, pain, and otalgia; a biopsy revealed dense subcutaneous tissue overlying and invading the parotid gland. What is your diagnosis? [image: First page PDF preview]
Bilateral Conductive Hearing Loss in a Young Boy
Bilateral Conductive Hearing Loss in a Young Boy: A boy presented with bilateral conductive hearing loss and delayed speech development. An audiogram demonstrated moderate low-frequency conductive hearing loss in the right ear and mild conductive hearing loss in the left ear with a normal tympanogram despite normal otoscopy results. What is your diagnosis? [image: First page PDF preview]
Locoregional Parotid Reconstruction
Locoregional Parotid Reconstruction: Parotidectomy for benign and malignant tumors often results in conspicuous contour abnormalities and soft tissue defects. Immediate reconstruction leads to improved patient satisfaction and local or regional flaps can be used for reconstruction in most cases. This article provides a systematic approach to parotid reconstruction.
Parotidectomy for Parotid Cancer
Parotidectomy for Parotid Cancer: Parotidectomy for parotid cancer includes management of primary salivary cancer, metastatic cancer to lymph nodes, and direct extension from surrounding structures or cutaneous malignancies. Preoperative evaluation should provide surgeons with enough information to plan a sound operation and adequately counsel patients. Facial nerve sacrifice is sometimes required; but in preoperative functioning nerves, function should be preserved. Although nerve involvement predicts poor outcome, survival of around 50% has been reported for primary parotid malign...περισσότερα »
MicroRNA-124 Suppresses Tumor Cell Proliferation and Invasion by Targeting CD164 Signaling Pathway in Non-Small Cell Lung Cancer
The post MicroRNA-124 Suppresses Tumor Cell Proliferation and Invasion by Targeting CD164 Signaling Pathway in Non-Small Cell Lung Cancer appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mLqVPg via IFTTT
Circumflex coronary artery injury after mitral valve surgery: A report of four cases and comprehensive review of the literature
As the LCx is closely related to the mitral valve annulus, it is susceptible to perioperative injury. Various underlying mechanisms, predisposing factors, and therapeutic strategies have been suggested but disagreement exists. Using a MeSH terms-based PubMed search, 44 cases of mitral valve surgery-related LCx injury were detected, including our 4 cases. We provide a comprehensive… Continue reading Circumflex coronary artery injury after mitral valve surgery: A report of four cases and comprehensive review of the literature
Thermodynamics of deposition flux-dependent intrinsic film stress
Article Vapour deposition on polycrystalline films can lead to unexpectedly high and reversible compressive stress, the origin of which remains unclear. Here, the authors show, using thermodynamic arguments, that entropic effects in the extremely dilute adatom gas on the surface play a major role. Nature Communications doi: 10.1038/ncomms10733 Authors: Amirmehdi Saedi, Marcel J. Rost from… Continue reading Thermodynamics of deposition flux-dependent intrinsic film stress
IJERPH, Vol. 13, Pages 231: Sunbed Use Prevalence and Associated Skin Health Habits: Results of a Representative, Population-Based Survey among Austrian Residents
Recreational sunbed use accounts for the main non-solar source of exposure to ultraviolet radiation in fair-skinned Western populations. Indoor tanning is associated with increased risks for acute and chronic dermatological diseases. The current community-based study assessed the one-year prevalence of sunbed use and associated skin health habits among a representative, gender-balanced sample of 1500 Austrian… Continue reading IJERPH, Vol. 13, Pages 231: Sunbed Use Prevalence and Associated Skin Health Habits: Results of a Representative, Population-Based Survey among Austrian Resid... περισσότερα »
Corrigendum: Delivery of crop pollination services is an insufficient argument for wild pollinator conservation
Corrigendum Nature Communications doi: 10.1038/ncomms10841 Authors: David Kleijn, Rachael Winfree, Ignasi Bartomeus, Luísa G Carvalheiro, Mickaël Henry, Rufus Isaacs, Alexandra-Maria Klein, Claire Kremen, Leithen K. M’Gonigle, Romina Rader, Taylor H. Ricketts, Neal M. Williams, Nancy Lee Adamson, John S. Ascher, András Báldi, Péter Batáry, Faye Benjamin, Jacobus C. Biesmeijer, Eleanor J. Blitzer, Riccardo Bommarco, Mariëtte… Continue reading Corrigendum: Delivery of crop pollination services is an insufficient argument for wild pollinator conservation
Corrigendum to “Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product” J. Neuroimmunol. 289 (2015) 121–129
The authors regret that one dedication to a grant support was inadvertently omitted (in the Acknowledgments). We would like to include this dedication in the form of Corrigendum. The article text was not changed. The corrected text of Acknowledgments follows: (Source: Journal of Neuroimmunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1KtOxDo via IFTTT from #Med… Continue reading Corrigendum to “Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product” J. Neuroimmunol. 289 (2015) 121–129
Early weaning is beneficial to prevent atopic dermatitis occurrence in young children
Abstract Background Epidemiological data on infant feeding practices and allergic diseases are controversial. The purpose of this study was to explore the association of early weaning with the occurrence of atopic dermatitis (AD). Methods We conducted a matched case-control study on incident physician-diagnosed AD in early childhood including 451 cases and 451 controls. Data on… Continue reading Early weaning is beneficial to prevent atopic dermatitis occurrence in young children
GSE68059 Regulatory landscape of a dimorphic and obligate intracellular pathogen
Contributors : Marie De Barsy ; Antonio Frandi ; Gael Panis ; Laurence Theraulaz ; Trestan Pillonel ; Gilbert Greub ; Patrick H Viollier Series Type : Genome binding/occupancy profiling by high throughput sequencing Organism : Waddlia chondrophila Both prokaryotic and eukaryotic organisms take deterministic decisions to reprogram cell fates. A macroscopic manifestation of such… Continue reading GSE68059 Regulatory landscape of a dimorphic and obligate intracellular pathogen
Consortium for Food Allergy Research: Clinical Research Units (UM1)
Funding Opportunity RFA-AI-15-051 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Clinical Research Units (CRUs) for the NIAID Consortium for Food Allergy Research (CoFAR). The CoFAR CRUs are responsible for implementation of clinical trials and studies for the Consortium. In addition… Continue reading Consortium for Food Allergy Research: Clinical Research Units (UM1)
Changes in Parent-Child Relationship Quality Across Early Adolescence:: Implications for Engagement in Sexual Behavior
The present study investigated how changes in specific dimensions of the parent–adolescent relationship predict adolescent engagement in sexual intercourse and oral sex. Longitudinal data from 1,364 participants in the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development were gathered at six time points spanning from first… Continue reading Changes in Parent-Child Relationship Quality Across Early Adolescence:: Implications for Engagement in Sexual Behavior
Individual and contextual correlates of obesity-related behaviours and obesity: the SPOTLIGHT project
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1KtGiat via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Interactions of individual perceived barriers and neighbourhood destinations with obesity-related behaviours in Europe
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Perceived barriers towards physical activity and healthy eating as well as local availability of opportunities (destinations in the neighbourhood) are important determinants of obesity-related behaviours in adults. Little is known, however, about how these factors interact with the behaviours. Data were analysed from 5,205 participants of the SPOTLIGHT survey, conducted in 60 neighbourhoods in […]
Exploring why residents of socioeconomically deprived neighbourhoods have less favourable perceptions of their neighbourhood environment than residents of wealthy neighbourhoods
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Residents of socioeconomically deprived areas perceive their neighbourhood as less conducive to healthy behaviours than residents of more affluent areas. Whether these unfavourable perceptions are based on objective neighbourhood features or other factors is poorly understood. We examined individual and contextual correlates of socioeconomic inequalities in neighbourhood perceptions across five urban regions in Europe. […]
The relation between sleep duration and sedentary behaviours in European adults
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Too much sitting, and both short and long sleep duration are associated with obesity, but little is known on the nature of the relations between these behaviours. We therefore examined the associations between sleep duration and time spent sitting in adults across five urban regions in Europe. We used cross-sectional survey data from 6,037 […]
Older age was associated with increased risk for CRSwNP and NSD but associated with a decreased risk for AR. Obesity was another risk factor for CRSwNP.
Prevalence and Risk Factors of Rhinologic Diseases in Korea: This cross-sectional study of a Korean population examines the prevalence and risk factors of chronic rhinosinusitis, allergic rhinitis, and nasal septal deviation. *Importance* Chronic rhinosinusitis (CRS), allergic rhinitis (AR), and nasal septal deviation (NSD) are frequent rhinologic diseases that consume considerable health care resources. *Objective* To determine the prevalence and risk factors of CRS, AR, and NSD in Korea. *Design, Setting, and Participants* This study analyzed 5-year cross-sectional data fro... περισσότερα »
Cerumen extraction is one of the most common procedures performed by otolaryngology health care professionals. Practice patterns and reimbursement rates vary greatly across the country.
Costs and Health Care Burden of Cerumen Extraction: This cross-sectional study quantifies the cost burden and health care burden of cerumen extraction among Medicare recipients in the United States. *Importance* Cerumen extractions are performed in a large portion of otolaryngology and head and neck surgery practices. The burden on the health care system of cerumen extractions is unknown and demographics have not been characterized at a population level. *Objective* To quantify the cost burden and health care burden of cerumen extraction among Medicare recipients in the United S...περισσότερα »
A Woman With Recurrent Unilateral Epistaxis
A Woman With Recurrent Unilateral Epistaxis: [image: s_ocg150048f1.png] A woman presented with recurrent right-sided epistaxis; maxillofacial CT without contrast demonstrated a mass in the right anterior nasal cavity, and there was no evidence of bony erosion or infiltration of the maxillary sinus. What is your diagnosis? [image: First page PDF preview]
DNMT1 Gene Mutation
A Patient With DNMT1 Gene Mutation: [image: s_olo150008f1.png] This case report highlights the pattern of hearing loss in patients with hereditary sensory and autonomic neuropathie type 1E. [image: First page PDF preview]
Local Drug Infiltration Analgesia During Knee Surgery to Reduce Postoperative Pain in Rats.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Background and Objectives: There is increasing interest in local infiltration analgesia (LIA) to reduce postoperative pain with knee surgery. Despite widespread use of LIA, wide variations in drug combinations, infiltration techniques, and the concomitant use of systemic analgesics have made it difficult to determine the optimal drug combination for LIA. Using a previously validated animal knee surgery model, we aimed to determine the optimal combination of medications to reduce postoperative pain, and the best anatomical location and timing for local drug injection during surgery. ... περισσότερα »
WISE 2005: Aerobic and resistive countermeasures prevent paraspinal muscle deconditioning during 60-days bed rest in women
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Microgravity-induced lumbar paraspinal muscle deconditioning may contribute to back pain commonly experienced by astronauts, and may increase the risk of postflight injury. We hypothesized that a combined resistance and aerobic exercise countermeasure protocol that included spinal loading would mitigate lumbar paraspinal muscle deconditioning during 60-days of bed rest in women. METHODS: Sixteen women underwent 60-day, 6° head-down-tilt bed rest and were randomized into control and exercise groups. During bed rest, the control group performed no exercise. The exercise group perform... περισσότερα »
Lung diffusing capacity for nitric oxide as a marker of fibrotic changes in idiopathic interstitial pneumonias
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Lung diffusing capacity for carbon monoxide (DLCO) is decreased in both usual interstitial pneumonia-idiopathic pulmonary fibrosis (UIP-IPF) and nonspecific interstitial pneumonia (NSIP), but is moderately related to computed tomography (CT)-determined fibrotic changes. This may be due to the relative insensitivity of DLCO to changes in alveolar membrane diffusive conductance (DMCO). The purpose of this study was to determine whether measurement of lung diffusing capacity for nitric oxide (DLNO) better reflects fibrotic changes than DLCO. DLNO-DLCO were measured simultaneously in ... περισσότερα »
Rapid cooling after acute hyperthermia alters intestinal tissue morphology and increases the systemic inflammatory response in pigs
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
The study objective was to determine the direct effects of rapid cooling after acute hyperthermia on intestinal morphology and inflammatory response in pigs. In 4 repetitions, male pigs (N=36; 88.7±1.6 kg) were exposed to thermoneutrality (TN; n = 3/rep; 19.5±0.1°C) for 6 h, or heat stress (HS; 36.4±0.1°C) for 3h, followed by a 3h recovery period of rapid cooling (HSRC; n=3/rep; rapid TN exposure and ice water dousing for 1.5h) or gradual cooling (HSGC; n=3/rep; gradual decrease from HS to TN). Rectal (TR) and gastrointestinal-tract temperatures (TGI) were obtained every 15 min fo... περισσότερα »
Long-Duration Bed Rest as an Analog to Microgravity
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Long-duration bed rest is widely employed to simulate the effects of microgravity on various physiological systems, especially for studies of bone, muscle and the cardiovascular system. This microgravity analog is also extensively used to develop and test countermeasures to microgravity-altered adaptations to Earth gravity. Initial investigations of bone loss used horizontal bed rest with the view that this model represented the closest approximation to inactivity and minimization of hydrostatic effects, but all Earth-based analogs must contend with the constant force of gravity b... περισσότερα »
A low-cost system to easily measure spontaneous physical activity in rodents.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
The Spontaneous Physical Activity (SPA) can be responsible for variations of a lot of physiological parameters at the molecular, cellular, tissue, and systemic levels. It is increasingly recognized that the good understanding of a large part of laboratory experimentations, implies to weight results by this SPA in order to reduce the variability, and so to decrease the number of animals necessary to conduct a study. However, because of the high cost of these equipment, only few laboratories are equipped with such a device to measure the SPA of their animals. Here, we present an eff... περισσότερα »
Two stages of directed forgetting: Electrophysiological evidence from a short-term memory task
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract In this study, a short-term memory test was used to investigate the temporal course and neural mechanism of directed forgetting under different memory loads. Within each trial, two memory items with high or low load were presented sequentially, followed by a cue indicating whether the presented items should be remembered. After an interval, subjects were asked to respond to the probe stimuli. The ERPs locked to the cues showed that (a) the effect of cue type was initially observed during the P2 (160–240 ms) time window, with more positive ERPs for remembering relative to ... περισσότερα »
Intracapsular Tonsillectomy in Children With Sleep Apnea
Intracapsular Tonsillectomy in Children With Sleep Apnea: This case series study assesses the effectiveness of powered intracapsular tonsillectomy and adenoidectomy in patients with severe obstructive sleep apnea as evidenced by polysomnographic parameter changes. *Importance* Powered intracapsular tonsillectomy and adenoidectomy (PITA) is an increasingly common pediatric procedure. Few studies have examined its effectiveness in children with severe obstructive sleep apnea (OSA). *Objective* To assess the effectiveness of PITA in patients with severe OSA as evidenced by change i... περισσότερα »
Rapidly Growing Lateral Neck Mass
Rapidly Growing Lateral Neck Mass: [image: s_ocg150047f1.png] A man in his 50s has a rapidly enlarging neck mass and recent weight loss; flexible laryngoscopy reveals reduced movement of the vocal cord, laryngeal deviation, and asymmetry and CT reveals a well-vascularized mass. What is your diagnosis? [image: First page PDF preview]
Bronchoscopy in Percutaneous Dilational Tracheostomy
Bronchoscopy in Percutaneous Dilational Tracheostomy: This cohort study evaluates the use of bronchoscopy for placement of percutaneous dilation tracheostomy, focusing on postprocedural complications and hospital length of stay. *Importance* A modified percutaneous dilational tracheostomy (PDT) is a relatively new alternative method of performing PDTs in which tissues overlying the trachea are dissected, but needle entry is still performed blindly. Many centers use bronchoscopy-assisted PDT, but the necessity of bronchoscope assistance for modified PDTs has not been examined. D...περισσότερα »
Sleep Studies in Children Who Snore
Commentary of “The Role of Sleep Studies in Children Who Snore”: [image: oic150001.pdf.gif] The pro/con perspective article by Ishman on the use of polysomnography (PSG) in snoring children analyzes a clinical question that faces numerous primary care physicians, otolaryngologists, and sleep medicine clinicians on a daily basis: “Should I order a sleep study for this child knowing it is an expensive and limited resource?” The scope of the issue is vast, involving hundreds of thousands of children annually in the United States alone. Thus, there have been substantial efforts made... περισσότερα »
Topical Mupirocin for Recalcitrant Chronic Rhinosinusitis
Topical Mupirocin for Recalcitrant Chronic Rhinosinusitis: This study assesses changes in microbiologic culture results before and after topical mupirocin therapy in patients with medically and surgically refractory chronic rhinosinusitis. *Importance* Topical mupirocin therapy is used to treat symptomatic chronic sinusitis (CRS). However, the potential adverse impact of this therapy on the sinus microbiota has not been well quantified. *Objective* To determine changes in microbiologic culture results before and after topical mupirocin therapy in patients with CRS with medically... περισσότερα »
Classification of Cholesteatoma According to Growth Patterns
Classification of Cholesteatoma According to Growth Patterns: This cross-sectional comparative study of 414 ears classifies cholesteatomas into subtypes and describes their prevalence. *Importance* Several classifications of cholesteatoma exist, but there are controversies about their clinical application. *Objective* To classify cholesteatomas and describe the prevalence of the subtypes. *Design, Setting, and Participants* A cross-sectional comparative study of 414 ears in 356 consecutive patients with middle ear cholesteatoma and no history of ear surgery treated at a tertiar... περισσότερα »
Nursing and Parental Comfort in Managing Pediatric Tracheostomy Care
Nursing and Parental Comfort in Managing Pediatric Tracheostomy Care: This survey study investigated nurse and parental comfort in managing acute and established tracheostomy tubes in pediatric patients. *Importance* Tracheostomy is a critical and often life-saving intervention, but associated risks are not negligible. The vulnerability of the pediatric population underlies the importance of caregiver comfort and competence in tracheostomy care. *Objective* To assess inpatient nursing staff and parental perspectives in managing tracheostomy care. *Design, Setting, and Participan... περισσότερα »
Repetitive Transcranial Magnetic Stimulation and Tinnitus
Repetitive Transcranial Magnetic Stimulation and Tinnitus: [image: ole150009.pdf.gif] *To the Editor* Regarding the recently published, randomized clinical trial by Folmer et al, using 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the temporal cortex in patients with tinnitus for 10 days compared with placebo, the authors reported a significant reduction in tinnitus symptoms, the primary outcome measure. However, rTMS for tinnitus is still not significantly beneficial, so we have some considerations to share:
A Critical Period in Postnatal Neuroplasticity of Olfaction
A Critical Period in Postnatal Neuroplasticity of Olfaction: This pilot study examines olfactory deficits from early chronic tracheostomy following decannulation and explores whether there is a critical period in the postnatal development and neuroplasticity of olfaction. *Importance* There is controversy over whether a critical period in the development of olfaction exists, as there is in hearing and vision, whereby early stimulation of the olfactory nerve is necessary for normal olfactory performance later in life. Children who undergo tracheotomy early in life are deprived of... περισσότερα »
A Mass Involving the Buccal Branch of the Facial Nerve
A Mass Involving the Buccal Branch of the Facial Nerve: [image: s_ocg150050f1.png] A 14-year-old girl had an asymptomatic, painless, slowly growing, invisible but palpable nodule in the cheek, and, after excision, light microscopy showed a septated, multilobular lesion with a myxoid stroma, cell nesting, and variable cellularity. What is your diagnosis? [image: First page PDF preview]
Changing Patterns in Inpatient Pediatric Adenotonsillectomy
Changing Patterns in Inpatient Pediatric Adenotonsillectomy: This study of Nationwide Inpatient Sample data determines whether regionalization of inpatient pediatric adenotonsillectomies has occurred with respect to teaching hospital status and the proportion of patients using Medicaid as the primary payer. *Importance* Pediatric adenotonsillectomy is one of the most frequently performed procedures in the United States. Whereas several studies have focused on tonsillectomy techniques and outcomes, little is known about the overall changes in the distribution of care. Variations ... περισσότερα »
Vascular Findings in the Cochlea in Patients With Presbycusis : The histopathologic findings of increased thickness of the vascular walls of the modiolar arteries and stria vascularis, increased strial atrophy, and decreased number of strial vessels may have led to decreased cochlear microcirculation. Deficiency in the circulation and perfusion of the cochlea may be a factor in presbycusis.
Vascular Findings in the Cochlea in Patients With Presbycusis: This analysis of age-related histopathologic changes of the stria vascularis and vessels in the cochlea compares autopsy reports of temporal bones of patients with presbycusis and a control group with normal hearing. *Importance* Age-related changes in cochlear vessel wall thickness in human temporal bones have not been described previously. *Objectives* To compare thickness of the spiral modiolar artery and strial capillaries and to investigate strial atrophy and vessel loss in temporal bones with and without presby... περισσότερα »
Primidone Therapy for Essential Vocal Tremor
*Primidone Therapy for Essential Vocal Tremor: This medical record review evaluates the efficacy of primidone in the treatment of essential vocal tremor. * *Importance Essential vocal tremor is difficult to treat. An effective pharmacologic treatment could allow patients to avoid or decrease the frequency or dosage of botulinum neurotoxin injections.* *Objective To evaluate the efficacy of primidone in the treatment of essential vocal tremor.* *Design, Setting, and Participants Medical records of all patients with a primary or secondary diagnosis of laryngeal spasm or essential... περισσότερα »
Respiratory Distress in a Neonate
Respiratory Distress in a Neonate: [image: s_ocg150051f1.png] A neonate had respiratory distress requiring endotracheal intubation, zygomatic hypoplasia, micrognathia, and bilateral grade III microtia with atresia of the external auditory canals, mild decrease in RV systolic function, and elevated pulmonary artery pressures. What is your diagnosis? [image: First page PDF preview]
Voice Assessment
Voice Assessment—Have We Done Enough?: [image: ovp150005.pdf.gif] This Viewpoint examines new American Thyroid Association guidelines that recommend a preoperative voice assessment for all patients undergoing thyroid surgery and suggests that the guidelines are deficient in their selective approach to preoperative and postoperative laryngeal examination.
The Role of Sleep Studies in Children Who Snore
The Role of Sleep Studies in Children Who Snore: This clinical review examines sleep studies, the only validated method of diagnosing obstructive sleep apnea, and determines if they are essential for children with tonsillar hypertrophy who snore and have symptoms of sleep-disordered breathing.
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