Angioimmunoblastic T-cell lymphoma mimicking dermatomyositis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
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A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor–dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2
A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor–dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2: Abstract BackgroundStage IV melanoma has high mortality, largely unaffected by traditional therapies. Immunotherapy including cytokine therapies and checkpoint inhibitors improves outcomes, but has significant toxicities. In this phase I/IIa trial, we investigated safety and efficacy of a dendritoma vaccine, an active, specific immunotherapy, in stage IV melanoma patients. MethodsAutologous tumor lysate and dendritic cells were fused c... περισσότερα »
Food allergy
: Epidemiology, pathogenesis, diagnosis, and treatment via ScienceDirect Search: baker’s asthma *Source:*Journal of Allergy and Clinical Immunology, Volume 133, Issue 2 Author(s): Scott H. Sicherer, Hugh A. Sampson This review focuses on advances and updates in the epidemiology, pathogenesis, diagnosis, and treatment of food allergy over the past 3 years since our last comprehensive review. On the basis of numerous studies, food allergy likely affects nearly 5% of adults and 8% of children, with growing evidence of an increase in prevalence. Potentially rectifiable risk factors include... περισσότερα »
Immunologic Contact Urticaria
Immunologic Contact Urticaria via ScienceDirect Search: baker’s asthma Publication date: February 2014 *Source:*Immunology and Allergy Clinics of North America, Volume 34, Issue 1 Author(s): John McFadden TeaserThe wheal and flare reaction from direct contact with a chemical or protein agent is known as contact urticaria. Contact urticaria can be either nonimmunologic (no sensitization required) or immunologic (sensitization required). Immunologic contact urticaria often gives a more aggravated response and has the potential to spread from the local vicinity. Skin testing in immunolog...περισσότερα »
Drug-Coated Balloon Versus Standard Balloon for Superficial Femoral Artery In-Stent Restenosis: The Randomized Femoral Artery In-Stent Restenosis (FAIR) Trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Drug-coated balloon angioplasty (DCBA) for superficial femoral artery (SFA) in-stent restenosis (ISR) is associated with less recurrent restenosis and a better clinical outcome than plain old balloon angioplasty (POBA) with no apparent differences in safety. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20Ppug7 via IFTTT
Aortic Curvature Instead of Angulation Allows Improved Estimation of the True Aorto-iliac Trajectory
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Supra- and infrarenal aortic neck angulation have been associated with complications after endovascular aortic aneurysm repair. However, a uniform angulation measurement method is lacking and the concept of angulation suggests a triangular oversimplification of the aortic anatomy. (Semi-)automated calculation of curvature along the center luminal line describes the actual trajectory of the aorta. This study […]
Contributions of planned readmissions and patient comorbidities to high readmission rates in vascular surgery patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Administrative data show that among surgical patients, readmission rates are highest in vascular surgery. Herein we analyze the contribution of planned readmissions and patient comorbidities to high readmission rates in vascular surgery. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20Pptc0 via IFTTT
Multi-layer Flow-modulating Stents for Thoraco-abdominal and Peri-renal Aneurysms: The UK Pilot Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
There remains a population of patients with aortic aneurysms that cannot be treated by conventional endovascular means. Multi-layer flow modulating stents (MFMS) are a novel approach for the treatment of aortic aneurysm; this study reports outcomes of a UK pilot study of first-generation MFMS in thoraco-abdominal (TAAA) and perirenal aneurysms (PAA) in patients who were […]
Information for authors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Complete information for authors and editorial policies are available in the January and July issues, at our Web site http://www.jvascsurg.org, or at our Editorial Manager Web site at jvs.editorialmanager.com. An abbreviated checklist for manuscript submission follows. Manuscripts that are accepted for publication become the property of the Journal of Vascular Surgery®, which is copyrighted by […]
Treatment of Aortic Prosthesis Infections by Graft Removal and In Situ Replacement with Autologous Femoral Veins and Fascial Strengthening
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Aortic prosthetic graft infection (AGI) is a major challenge in vascular surgery. Eradicating the infection requires prosthetic material removal, debridement, and lower limb revascularization. For the past 15 years, we have used femoral veins for aorto-iliac reconstruction and tensor fascia lata to strengthen the upper anastomosis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/218uz8D via IFTTT
Editorial Board
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20Ppsot via IFTTT
Bone Like Arterial Calcification in Femoral Atherosclerotic Lesions: Prevalence and Role of Osteoprotegerin and Pericytes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Arterial calcification, a process that mimics bone formation, is an independent risk factor of cardiovascular morbidity and mortality, and has a significant impact on surgical and endovascular procedures and outcomes. Research efforts have focused mainly on the coronary arteries, while data regarding the femoral territory remain scarce. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/218uyBL via […]
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. Helicobacter pylori (H. pylori) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and H. pylori may play a protective role […]
Healing process following laser cordectomy of early glottis carcinoma from endoscopic view
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 20 δευτερόλεπτα
Background and Objective Transoral laser surgery is useful for treating early glottic carcinoma. Wound areas after carbon dioxide (CO2) laser surgery are not covered by flaps, delaying healing. The healing process following laser cordectomy is not well understood. In this study, laryngoscopes were used to monitor the normal healing process after laser cordectomy and to […]
Misperception of tiredness in young adults with insomnia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Summary People with insomnia often exhibit interpretive biases to cues associated with their condition. This study examined whether individuals with insomnia display an interpretive bias, such that they misperceive facial attributes of tiredness in a disorder-consistent manner. The efficacy of providing feedback related to the accuracy of participants’ perception on later judgements of tiredness was […]
Oxygen desaturation during night sleep affects decision-making in patients with obstructive sleep apnea
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Summary This study assessed decision-making and its associations with executive functions and sleep-related factors in patients with obstructive sleep apnea. Thirty patients with untreated obstructive sleep apnea and 20 healthy age- and education-matched controls performed the Iowa Gambling Task, a decision-making task under initial ambiguity, as well as an extensive neuropsychological test battery. Patients, but […]
Determination of the stoichiometry of the complete bacterial type III secretion needle complex using a combined quantitative proteomic approach Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Critical for investigating structure, assembly, and function of macromolecular machines is to precisely know the stoichiometry of their components. In particular for large, hydrophobic membrane-spanning complexes, this has remained a technical challenge. Here we determined the stoichiometry of a type III secretion system of Salmonella enterica serovar Typhimurium using two complementary protocols of gentle complex […]
Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2-proficient (Nrf2+/+) and -deficient (Nrf2−/−) mice were exposed to potassium bromate (KBrO3) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intestine and exhibited accumulations of β-catenin and cyclin D1. The lesions […]
Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract A small population of cells with stem cell-like properties in prostate cancer (PCa), called prostate cancer stem cells (PrCSCs) or prostate stemness-high cancer cells, displays highly tumorigenic and metastatic features and may be responsible for the therapy resistance. A small molecule, napabucasin (BBI608), recently have been identified with suppression of stemness-high cancer cells in […]
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis […]
Redox Status and Proteostasis in Ageing and Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OpeU8p via IFTTT
Novel Analytical and Numerical Methods in Heat Transfer Enhancement and Thermal Management
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24ma8Ej via IFTTT
False Negative Cell-Free DNA Screening Result in a Newborn with Trisomy 13
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background. Noninvasive prenatal screening (NIPS) is revolutionizing prenatal screening as a result of its increased sensitivity, specificity. NIPS analyzes cell-free fetal DNA (cffDNA) circulating in maternal plasma to detect fetal chromosome abnormalities. However, cffDNA originates from apoptotic placental trophoblast; therefore cffDNA is not always representative of the fetus. Although the published data for NIPS testing […]
2016-02-22T00:00:00Z Restrictions on opioid pills could hurt innocent citizens stltoday.com – STLtoday.com
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
2016-02-22T00:00:00Z Restrictions on opioid pills could hurt innocent citizens stltoday.com STLtoday.com Before my wife died, she had successive surgeries for cancer of the esophagus and larynx and went through months of being unable to swallow after each surgery, getting all of her nourishment and medicine injected into her small intestine through a “J-tube. and more […]
Top-down approach to the superior mesenteric artery and the mesopancreas during pancreatoduodenctomy for pancreatic cancer
Complete surgical resection with microscopically tumor-free resection margins (R0) is the most important survival determinant for patients with localized pancreatic cancer. The medial and posterior resection margins are the dominant sites of microscopic tumor involvement, and outline the so-called *mesopancreas*. In this study, we present a modified surgical approach to the superior mesenteric artery, celiac trunc, and mesopancreas during pancreatoduodenectomy, which enables a comfortable exposure and radical en bloc clearance of the mesopancreas and the tissue adjacent to the su...περισσότερα »
Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Abstract A small population of cells with stem cell-like properties in prostate cancer (PCa), called prostate cancer stem cells (PrCSCs) or prostate stemness-high cancer cells, displays highly tumorigenic and metastatic features and may be responsible for the therapy resistance. A small molecule, napabucasin (BBI608), recently have been identified with suppression of stemness-high cancer cells in… Continue reading Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Ciliopathy Mutant Cochlea
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea: Primary cilia influence various signaling pathways. The mammalian cochlea is ideal for examining planar cell polarity (PCP) signaling. Cilia dysfunction affects cochlear outgrowth, cellular patterning and hair cell orientation, readouts of PCP. Our goal is to analyze PCP signaling in mouse cochlea via phenotypic analysis, immunohistochemistry… Continue reading Ciliopathy Mutant Cochlea
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis… Continue reading Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Abstract A small population of cells with stem cell-like properties in prostate cancer (PCa), called prostate cancer stem cells (PrCSCs) or prostate stemness-high cancer cells, displays highly tumorigenic and metastatic features and may be responsible for the therapy resistance. A small molecule, napabucasin (BBI608), recently have been identified with suppression of stemness-high cancer cells in… Continue reading Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. Helicobacter pylori (H. pylori) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and H. pylori may play a protective role… Continue reading Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis… Continue reading Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Determination of the stoichiometry of the complete bacterial type III secretion needle complex using a combined quantitative proteomic approach Research
Critical for investigating structure, assembly, and function of macromolecular machines is to precisely know the stoichiometry of their components. In particular for large, hydrophobic membrane-spanning complexes, this has remained a technical challenge. Here we determined the stoichiometry of a type III secretion system of Salmonella enterica serovar Typhimurium using two complementary protocols of gentle complex… Continue reading Determination of the stoichiometry of the complete bacterial type III secretion needle complex using a combined quantitative proteomic approach Research
Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice
Abstract To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2-proficient (Nrf2+/+) and -deficient (Nrf2−/−) mice were exposed to potassium bromate (KBrO3) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intestine and exhibited accumulations of β-catenin and cyclin D1. The lesions… Continue reading Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice
Determination of the stoichiometry of the complete bacterial type III secretion needle complex using a combined quantitative proteomic approach Research
Critical for investigating structure, assembly, and function of macromolecular machines is to precisely know the stoichiometry of their components. In particular for large, hydrophobic membrane-spanning complexes, this has remained a technical challenge. Here we determined the stoichiometry of a type III secretion system of Salmonella enterica serovar Typhimurium using two complementary protocols of gentle complex… Continue reading Determination of the stoichiometry of the complete bacterial type III secretion needle complex using a combined quantitative proteomic approach Research
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis… Continue reading Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Pragmatic Language Features of Mothers With the FMR1 Premutation Are Associated With the Language Outcomes of Adolescents and Young Adults With Fragile X Syndrome
Pragmatic Language Features of Mothers With the FMR1 Premutation Are Associated With the Language Outcomes of Adolescents and Young Adults With Fragile X Syndrome: Purpose Pragmatic language difficulties have been documented as part of the FMR1 premutation phenotype, yet the interplay between these features in mothers and the language outcomes of their children with fragile X syndrome is unknown. This study aimed to determine whether pragmatic language difficulties in mothers with the FMR1 premutation are related to the language development of their children. Method Twenty-seven ... περισσότερα »
Fun
Friday fun: [image: 515d9b3074b74b522e353f4c985c5b9f.jpg]
Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer
Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer: Abstract BackgroundThe p75 neurotrophin receptor (p75NTR) is a cancer stem cell (CSC) marker in esophageal squamous cell carcinoma (ESCC). This study aimed to assess the use of p75NTR in detecting circulating tumor cells (CTCs) in ESCC. MethodsPeripheral blood mononuclear cell expression of epithelial cell adhesion molecule (EpCAM) and p75NTR was detected in 23 ESCC patients (13 received chemo- or chemoradiotherapy and 10 received curative surgery) and 10 healthy controls by flow cyto...περισσότερα »
Tufted angioma of the maxilla: a rare case with unique clinical presentation.
Tufted angioma of the maxilla: a rare case with unique clinical presentation.: Authors: Katsoulas N, Nikitakis N, Theologie-Lygidakis N, Lianou V, Tsiklakis K, Iatrou I, Sklavounou-Andrikopoulou A Abstract Tufted angioma is an uncommon benign vascular tumor usually presenting in early childhood and affecting mainly the skin. It has been associated with Kasabach-Merritt syndrome, a severe coagulopathy of poor prognosis. There have been very few published cases of oral tufted angiomas, and maxillary bone involvement has not been hitherto reported. We present a case of a 10-year-old ...περισσότερα »
THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter (OTC) Thyroid Supplements.
THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter (OTC) Thyroid Supplements.: Thyroid. 2016 Feb 19; Authors: Han SX, Eisenberg M, Larsen PR, DiStefano Iii JJ Abstract BACKGROUND: Computer simulation tools for education and research are making increasingly effective use of the internet and personal devices. To facilitate these activities in endocrinology and metabolism, we developed and further validated a mechanistically-based simulator of human thyroid hormone and thyrotropin regulation dynamics, implementing it as a facile and freely acc...περισσότερα »
Resident Training in Anaphylaxis
A Simple Allergist-Led Intervention Improves Resident Training in Anaphylaxis: Physicians underrecognize and undertreat anaphylaxis. Effective interventions are needed to improve physician knowledge and competency regarding evidence-based anaphylaxis diagnosis and management (ADAM). We designed and evaluated an educational program to improve ADAM in pediatrics, internal medicine, and emergency medicine residents from two academic medical centers. Anonymous questionnaires queried participants’ demographics, prior ADAM clinical experience, competency, and comfort. A pretest assessing ... περισσότερα »
Practice patterns in the intraoperative use of bispectral index monitoring
Practice patterns in the intraoperative use of bispectral index monitoring: AbstractAssessing the depth of anesthesia and reducing intraoperative awareness has become a focus of much technology development and research in the field of anesthesia. Bispectral index (BIS) is the most widely utilized technology that uses electroencephalogram to provide a measurement of anesthetic depth. There are no definitive guidelines on when BIS should be used. Our aim was to assess actual patterns of intraoperative use of BIS by anesthesia professionals. We retrospectively collected intraoperative ...περισσότερα »
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study: Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis in a population-based case–control study conducted in the United States. A total of 253 SCC... περισσότερα »
IMPORTANCE OF SERATONIN GENE RELATED PEPTIDE (SGRP) IN MIGRAINE
IMPORTANCE OF SERATONIN GENE RELATED PEPTIDE (SGRP) IN MIGRAINE: 2016-02-21T18-08-03Z *Source:* International Journal of Health and Rehabilitation Sciences (IJHRS) Sivanandan Ramar, Sankaran Ponnusamy, Salameh Al Dajah. Migraine is a neurovascular disorder involving trigeminal ganglion characterized by recurrent episodic headache and rise in levels of Serotonin Gene Related Protein (SGRP) in plasma. SGRP is a neuropeptide present in the central and peripheral nervous system that has diverse functions as primary afferent neurotransmitter which is important in nociception. In this... περισσότερα »
Ciliopathy Mutant Cochlea
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea: [image: 53559fig1.jpg] Primary cilia influence various signaling pathways. The mammalian cochlea is ideal for examining planar cell polarity (PCP) signaling. Cilia dysfunction affects cochlear outgrowth, cellular patterning and hair cell orientation, readouts of PCP. Our goal is to analyze PCP signaling in mouse cochlea via phenotypic analysis, immunohistochemistry and scanning electron microscopy.
Evaluation of gum-elastic bougie with direct and indirect laryngoscope for infant difficult airway management: a Pierre Robin simulation model
Evaluation of gum-elastic bougie with direct and indirect laryngoscope for infant difficult airway management: a Pierre Robin simulation model: Pierre Robin sequence is a collection of rare clinical findings including micrognathia, glossoptosis, and cleft palate, and airway management of these patients is generally difficult [1]. The tracheal tube introducer (gum-elastic bougie; GEB) is a commonly used airway tool for difficult intubation. We recently reported on the GEB utility for simulated infant difficult airway management modulated by cervical stabilization or anteflexion [2]. ... περισσότερα »
Effects of Nrf2 silencing on oxidative stress-associated intestinal carcinogenesis in mice
Abstract To assess the risk of colorectal cancer in humans with inactivation of NRF2, *Nrf2*-proficient (*Nrf2*+/+) and -deficient (*Nrf2*−/−) mice were exposed to potassium bromate (KBrO3) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intestine and exhibited accumulations of *β*-catenin and cyclin D1. The lesions had characteristics similar to those in experimental models of human hereditary colorectal cancer. An additional 13-week study was performed to examine the role of Nrf2 in the effects of oxidative stress. S... περισσότερα »
Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin
Abstract A small population of cells with stem cell-like properties in prostate cancer (PCa), called prostate cancer stem cells (PrCSCs) or prostate stemness-high cancer cells, displays highly tumorigenic and metastatic features and may be responsible for the therapy resistance. A small molecule, napabucasin (BBI608), recently have been identified with suppression of stemness-high cancer cells in a variety of cancers. However, the effects of napabucasin on PCa cells as well as PrCSCs isolated from PCa cells have not yet been defined. The effect of napabucasin on PCa cells in cell ...περισσότερα »
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis in a population-based case–control study conducted in the United States. A total of 253 SCC cases and 460 age group and gender-matched controls were included. Antibody response against each PyV was measu...περισσότερα »
Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Squamous cell carcinoma (SCC) of the skin is a malignancy arising from epithelial keratinocytes. Experimental and epidemiologic evidence raise the possibility that human polyomaviruses (PyV) may be associated with the occurrence of SCC. To investigate whether the risk for SCC was associated with PyV infection, seropositivity to 10 PyV types was assessed following diagnosis in a population-based case–control study conducted in the United States. A total of 253 SCC cases and 460 age group and gender-matched controls were included. Antibody response against each PyV was measu...περισσότερα »
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. *Helicobacter pylori* (*H. pylori*) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and *H. pylori* may play a protective role in these conditions. Little is known about the relationship between EoE and *H. pylori*. Aim To investigate in a case–control study whether *H. pylori* in... περισσότερα »
Clinically assessed posttraumatic stress in patients with breast cancer during the first year after diagnosis in the prospective, longitudinal, controlled COGNICARES study
Abstract Objective There is ongoing debate whether cancer qualifies as traumatic stressor. We investigated prevalence and course of posttraumatic stress in patients with early breast cancer (BC) during their first year after diagnosis and determined effects of mastectomy and chemotherapy. Methods Patients with stage 0–III BC aged ≤65 years were evaluated with the Structured Clinical Interview for DSM-IV modules for acute and posttraumatic stress disorder (ASD and PTSD, respectively) before treatment, after chemotherapy, and 1 year after diagnosis. Matched controls were assessed ... περισσότερα »
Predator Odor Components
Behavioral Responses of CD-1 Mice to Six Predator Odor Components.: Chem Senses. 2016 Feb 18; Authors: Sievert T, Laska M Abstract Mammalian prey species are able to detect predator odors and to display appropriate defensive behavior. However, there is only limited knowledge about whether single compounds of predator odors are sufficient to elicit such behavior. Therefore, we assessed if predator-naïve CD-1 mice (n = 60) avoid sulfur-containing compounds that are characteristic components of natural predator odors and/or display other indicators of anxiety. A 2-compartment test ar...περισσότερα »
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
Publication date: April 2016 *Source:*European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated the expression of PD-L1 in surgically resected stage I pulmonary squamous cell carcinoma (SqCC) and correlated it with TILs in tumour microenvironments, common driver ... περισσότερα »
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. *Helicobacter pylori* (*H. pylori*) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and *H. pylori* may play a protective role in these conditions. Little is known about the relationship between EoE and *H. pylori*. Aim To investigate in a case–control study whether *H. pylori* in... περισσότερα »
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. *Helicobacter pylori* (*H. pylori*) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and *H. pylori* may play a protective role in these conditions. Little is known about the relationship between EoE and *H. pylori*. Aim To investigate in a case–control study whether *H. pylori* in... περισσότερα »
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: April 2016 *Source:*European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated the expression of PD-L1 in surgically resected stage I pulmonary squamous cell carcinoma (SqCC) and correlated it with TILs in tumour microenvironments, common driver ... περισσότερα »
Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Background and Objective Vibrational spectroscopic methods associated with multivariate statistical techniques have been succeeded in discriminating skin lesions from normal tissues. However, there is no study exploring the potential of these techniques to assess the alterations promoted by photodynamic effect in tissue. The present study aims to demonstrate the ability of Fourier Transform Infrared (FTIR) spectroscopy on Attenuated total reflection (ATR) sampling mode associated with principal component-linear discriminant analysis (PC-LDA) to evaluate the biochemical changes cau... περισσότερα »
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis
Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis: Summary Background Eosinophilic oesophagitis (EoE) represents a chronic immune-antigen-mediated allergic disease of the oesophagus of still unknown aetiology. Environmental exposure has been postulated to play a pathogenetic role. *Helicobacter pylori* (*H. pylori*) infection has been inversely associated with allergic diseases including atopic dermatitis, asthma and allergic rhinitis and *H. pylori* may play a protective role in these conditions. Little is known about the relat...περισσότερα »
Pollinosis to tree of heaven (Ailanthus altissima) and detection of allergenic proteins
Pollinosis to tree of heaven () and detection of allergenic proteins: a case report: The tree of heaven (Ailanthus altissima), native to China, belongs to the Simaroubaceae family. This tree has spread from a prized ornamental plant to a highly invasive species in many regions worldwide.1 During the last 2 decades, this species was introduced in arid and semiarid regions of Iran as a cultivated species and is now present as an invasive plant in most parts of the country.2 Despite several clinical reports of allergy to A altissima pollen,3–5 the allergens responsible for allergic sym... περισσότερα »
Local and systemic reactions to subcutaneous allergen immunotherapy
Local and systemic reactions to subcutaneous allergen immunotherapy: BackgroundLocal and especially systemic reactions are important problems in subcutaneous immunotherapy (SCIT). Local and systemic reactions develop in 0.7% to 4% and 0.2% of all injections, respectively.ObjectiveTo evaluate the frequency of and risk factors for reactions developing in pediatric patients undergoing SCIT.MethodsLocal and systemic reactions developing after 14,308 injections between 2003 and 2013 were retrospectively evaluated in the current study using the Subcutaneous Immunotherapy Systemic Reacti...περισσότερα »
Stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria
Association among stress, hypocortisolism, systemic inflammation, and disease severity in chronic urticaria: BackgroundChronic urticaria (CU) is an immune-mediated disease characterized by wheals for at least 6 weeks. The role of stress and the correlation of stress, hypocortisolism, and inflammatory markers are not well understood.ObjectivesTo estimate C-reactive protein (CRP), interleukin (IL)-18, and cortisol levels in patients with CU and to explore their association with disease severity and stress.MethodsForty-five patients with CU and 45 age- and sex-matched healthy control...περισσότερα »
CT Esophagram Findings after Peroral Endoscopic Myotomy
Prospective Evaluation of CT Esophagram Findings after Peroral Endoscopic Myotomy: Peroral endoscopic myotomy (POEM) is a procedure with potential for serious adverse events. Postprocedure imaging is routinely done yet there is no consensus on the optimal imaging protocol. We describe a novel and simple CT esophagram protocol for post-POEM evaluation and report the full spectrum of radiographic findings and subsequent interventions.
Healing process following laser cordectomy of early glottis carcinoma from endoscopic view
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Objective Transoral laser surgery is useful for treating early glottic carcinoma. Wound areas after carbon dioxide (CO2) laser surgery are not covered by flaps, delaying healing. The healing process following laser cordectomy is not well understood. In this study, laryngoscopes were used to monitor the normal healing process after laser cordectomy and to […]
Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Objective Vibrational spectroscopic methods associated with multivariate statistical techniques have been succeeded in discriminating skin lesions from normal tissues. However, there is no study exploring the potential of these techniques to assess the alterations promoted by photodynamic effect in tissue. The present study aims to demonstrate the ability of Fourier Transform Infrared (FTIR) […]
Computer simulations of thermal tissue remodeling during transvaginal and transurethral laser treatment of female stress urinary incontinence
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background and Objectives A non-surgical method is being developed for treating female stress urinary incontinence by laser thermal remodeling of subsurface tissues with applied surface tissue cooling. Computer simulations of light transport, heat transfer, and thermal damage in tissue were performed, comparing transvaginal and transurethral approaches. Study Design/Materials and Methods Monte Carlo (MC) simulations provided […]
Polidocanol injection therapy for hemangioma using double-balloon endoscopy
Polidocanol injection therapy for small-bowel hemangioma using double-balloon endoscopy: Small-bowel hemangioma is a rare disease that often causes active bleeding. The standard therapeutic method for small-bowel hemangioma is surgical resection. The aim of this study was to evaluate the usefulness of polidocanol injection (PDI) for small-bowel hemangioma.
Maximizing Outcomes for Children with Auditory Disorders: Auditory Brain Development - Listening for Learning
Maximizing Outcomes for Children with Auditory Disorders: Auditory Brain Development - Listening for Learning: What is Hearing? Hearing is a first-order event for the development of spoken communication and literacy skills. Anytime the word hearing is used, we should think auditory brain development, because we hear with the brain. We may assume that people know that we hear with the brain, well just like we see with the brain. The eyes are the doorway to the brain for vision. The mouth is the doorway to the brain for taste. The nose is the doorway to the brain for smell. Those are ... περισσότερα »
Maximizing Outcomes for Children with Auditory Disorders: An Evidence-Based Approach to Managing Auditory Processing Disorders
Maximizing Outcomes for Children with Auditory Disorders: An Evidence-Based Approach to Managing Auditory Processing Disorders: Auditory processing disorder, or central auditory processing disorder (CAPD) is a breakdown in auditory abilities resulting in diminished learning or comprehension through hearing, even though peripheral hearing sensitivity is normal. Today we are not talking about children with peripheral hearing loss. We are talking about those children with normal peripheral hearing acuity who demonstrate auditory processing issues and who have been formally identified.
Preschoolers' Acquisition of Novel Verbs in the Double Object Dative
Preschoolers' Acquisition of Novel Verbs in the Double Object Dative: Abstract Children have difficulty comprehending novel verbs in the double object dative (e.g., *Fred blicked the dog a stick*) as compared to the prepositional dative (e.g., *Fred blicked a stick to the dog*). We explored this pattern with 3 and 4 year olds (*N* = 60). In Experiment 1, we replicated the documented difficulty with the double object frame, even though we provided more contextual support. In Experiment 2, we tested a novel hypothesis that children would comprehend novel verbs in, and generalize them... περισσότερα »
Serum Amyloid A1 Secreted from UV-irradiated Keratinocytes Induces Matrix Metalloproteinase-1 in Fibroblasts through Toll-like Receptor 4
Serum Amyloid A1 Secreted from UV-irradiated Keratinocytes Induces Matrix Metalloproteinase-1 in Fibroblasts through Toll-like Receptor 4: Abstract Ultraviolet (UV) irradiation on skin triggers photoaging-related phenotypes such as formation of wrinkles. UV ray up-regulates matrix metalloproteinase-1 (MMP-1), which in turn degrades extracellular matrix proteins, mostly collagens. Serum amyloid A1 (SAA1) is an acute-phase protein of which plasma concentration increases in response to inflammation. Although the expression of SAA1 in the skin was reported, its function in the skin is ...περισσότερα »
Biological effects induced by photodynamic therapy
Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy: Background and Objective Vibrational spectroscopic methods associated with multivariate statistical techniques have been succeeded in discriminating skin lesions from normal tissues. However, there is no study exploring the potential of these techniques to assess the alterations promoted by photodynamic effect in tissue. The present study aims to demonstrate the ability of Fourier Transform Infrared (FTIR) spectroscopy on Attenuated total reflection (ATR) sampling mode asso... περισσότερα »
Healing process following laser cordectomy of early glottis carcinoma from endoscopic view
Healing process following laser cordectomy of early glottis carcinoma from endoscopic view: Background and Objective Transoral laser surgery is useful for treating early glottic carcinoma. Wound areas after carbon dioxide (CO2) laser surgery are not covered by flaps, delaying healing. The healing process following laser cordectomy is not well understood. In this study, laryngoscopes were used to monitor the normal healing process after laser cordectomy and to determine if there was residual or recurrent disease. Materials and Methods This prospective case study included 36 patients ... περισσότερα »
Bimanual Coordination Learning with Different Augmented Feedback Modalities and Information Types
Bimanual Coordination Learning with Different Augmented Feedback Modalities and Information Types: [image: journal.pone.0149221.g001] by Shiau-Chuen Chiou, Erik Chihhung Chang Previous studies have shown that bimanual coordination learning is more resistant to the removal of augmented feedback when acquired with auditory than with visual channel. However, it is unclear whether this differential “guidance effect” between feedback modalities is due to enhanced sensorimotor integration via the non-dominant auditory channel or strengthened linkage to kinesthetic information under r...περισσότερα »
Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis
Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis: [image: journal.pone.0149576.t001] by Wanda G. H. Han, Hennie M. Hodemaekers, Bhawani Nagarajah, Martien M. C. Poelen, Kina Helm, Riny Janssen, Cécile A. C. M. van Els Pertussis, caused by infection with the gram negative *B*. *pertussis* bacterium, is a serious respiratory illness that can last for months. While *B*. *pertussis* infection rates are estimated between 1–10% in the general population, notifications of symptomatic pertussis only comprise 0.01–0.1% indicating that most indi... περισσότερα »
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone
A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone: [image: journal.pone.0149410.e001.PNG] by Nathalie Daude, Inyoul Lee, Taek-Kyun Kim, Christopher Janus, John Paul Glaves, Hristina Gapeshina, Jing Yang, Brian D. Sykes, George A. Carlson, Leroy E. Hood, David Westaway Pituitary Prolactin (PRL) and Growth Hormone (GH) are separately controlled and sub-serve different purposes. Surprisingly, we demonstrate that extra-pituitary expression in the adult mammalian central nervous system (CNS) is coordinated at mRNA and ... περισσότερα »
Focal Length Affects Depicted Shape and Perception of Facial Images
Focal Length Affects Depicted Shape and Perception of Facial Images: [image: journal.pone.0149313.g001] by Vít Třebický, Jitka Fialová, Karel Kleisner, Jan Havlíček Static photographs are currently the most often employed stimuli in research on social perception. The method of photograph acquisition might affect the depicted subject’s facial appearance and thus also the impression of such stimuli. An important factor influencing the resulting photograph is focal length, as different focal lengths produce various levels of image distortion. Here we tested whether different focal ... περισσότερα »
Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium
Texture Descriptors Ensembles Enable Image-Based Classification of Maturation of Human Stem Cell-Derived Retinal Pigmented Epithelium: [image: journal.pone.0149399.t001] by Loris Nanni, Michelangelo Paci, Florentino Luciano Caetano dos Santos, Heli Skottman, Kati Juuti-Uusitalo, Jari Hyttinen Aims A fast, non-invasive and observer-independent method to analyze the homogeneity and maturity of human pluripotent stem cell (hPSC) derived retinal pigment epithelial (RPE) cells is warranted to assess the suitability of hPSC-RPE cells for implantation or *in vitro* use. The aim of t... περισσότερα »
Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases
Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases: [image: journal.pone.0149294.g001] by Donghyun Jee, Seungbum Kang, Changzheng Yuan, Eunyoung Cho, Jorge G. Arroyo, The Epidemiologic Survey Committee of the Korean Ophthalmologic Society Purpose To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods A tota...περισσότερα »
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated […]
Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The post Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mS4FmW via IFTTT
Shell station in St Albans criticised for “sneaky” parking fines – Herts Advertiser
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Herts Advertiser Shell station in St Albans criticised for “sneaky” parking fines Herts Advertiser He has problems communicating as he had part of his tongue removed after suffering mouth cancer, and is deaf. The man’s son died suddenly before Christmas, and social care services have been almost non-existent since then. Becki offered to drop off […]
A brother’s mourning clothes: I wanted a uniform of grief – Salon
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Salon A brother’s mourning clothes: I wanted a uniform of grief Salon But after my younger sister, Jennifer, died from cancer at the age of 22, I came to see things differently. Staring at the chart, afterward, …. So when she first noticed a painful sore on her tongue no one suspected anything too sinister. […]
Cognitive flexibility, heart rate variability, and resilience predict fine-grained regulation of arousal during prolonged threat
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Emotion regulation in the ongoing presence of a threat is essential for adaptive behavior. Threatening situations change over time and, as a consequence, require a fine-tuned, dynamic regulation of arousal to match the current state of the environment. Constructs such as cognitive flexibility, heart rate variability, and resilience have been proposed as resources for […]
Weight and height during adolescence may impact future risk of developing non-Hodgkin’s lymphoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A new analysis indicates that higher body weight and taller stature during adolescence increase the risk of developing non-Hodgkin’s lymphoma (NHL), a type of cancer of the lymphatic system. The findings are published early online in Cancer, a… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oCTkZz via IFTTT
Attention deficit hyperactivity disorder
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Attention deficit hyperactivity disorder: A disorder in which a person is unable to control behavior due to difficulty in processing neural stimuli, accompanied by an extremely high level of motor activity. Abbreviated ADHD. ADHD can affect children and adults, but it is easiest to perceive during schooling. A child with ADHD may be extremely distractible, […]
PXR- and CAR-mediated herbal effect on human diseases
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 22 February 2016 Source:Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms Author(s): Chenshu Xu, Min Huang, Huichang Bi The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that regulate a broad range of genes involved in drug metabolism and transport. A […]
Discussions about reproductive and sexual health among young adult survivors of cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Fertility preservation and sexual health are increasingly important as more young cancer patients survive their disease. Our aims were to describe the frequency with which reproductive and sexual health discussions occur, and to identify clinical factors associated with these discussions. Medical records of patients aged 20–39 diagnosed with solid tumors from 2008–2010 who survived […]
Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis
Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis: [image: journal.pone.0149618.g001] by Meng-Hsuan Ho, Li Huang, J. Shawn Goodwin, Xinhong Dong, Chin-Ho Chen, Hua Xie *Porphyromonas gingivalis* is a keystone pathogen of periodontitis. One of its bacterial characteristics is the ability to invade various host cells, including nonphagocytic epithelial cells and fibroblasts, which is known to facilitate *P*. *gingivalis* adaptation and survival in the gingival environment. In this study, we investigated two small compounds, Alop1 and dynasore, fo... περισσότερα »
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated […]
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated […]
Programmed cell death-ligand 1 expression is associated with a favourable immune microenvironment and better overall survival in stage I pulmonary squamous cell carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: April 2016 Source:European Journal of Cancer, Volume 57 Author(s): Ching-Yao Yang, Mong-Wei Lin, Yih-Leong Chang, Chen-Tu Wu, Pan-Chyr Yang BackgroundProgrammed cell death-ligand 1 (PD-L1) is expressed in a subgroup of lung cancer that may benefit from immunotherapy. The interaction between PD-L1 expression and tumour infiltrating lymphocytes (TIL) remains poorly understood. This study investigated […]
Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The post Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mS4FmW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Shell station in St Albans criticised for “sneaky” parking fines – Herts Advertiser
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Herts Advertiser Shell station in St Albans criticised for “sneaky” parking fines Herts Advertiser He has problems communicating as he had part of his tongue removed after suffering mouth cancer, and is deaf. The man’s son died suddenly before Christmas, and social care services have been almost non-existent since then. Becki offered to drop off […]
A brother’s mourning clothes: I wanted a uniform of grief – Salon
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Salon A brother’s mourning clothes: I wanted a uniform of grief Salon But after my younger sister, Jennifer, died from cancer at the age of 22, I came to see things differently. Staring at the chart, afterward, …. So when she first noticed a painful sore on her tongue no one suspected anything too sinister. […]
Healing process following laser cordectomy of early glottis carcinoma from endoscopic view
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background and Objective Transoral laser surgery is useful for treating early glottic carcinoma. Wound areas after carbon dioxide (CO2) laser surgery are not covered by flaps, delaying healing. The healing process following laser cordectomy is not well understood. In this study, laryngoscopes were used to monitor the normal healing process after laser cordectomy and to […]
Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background and Objective Vibrational spectroscopic methods associated with multivariate statistical techniques have been succeeded in discriminating skin lesions from normal tissues. However, there is no study exploring the potential of these techniques to assess the alterations promoted by photodynamic effect in tissue. The present study aims to demonstrate the ability of Fourier Transform Infrared (FTIR) […]
Computer simulations of thermal tissue remodeling during transvaginal and transurethral laser treatment of female stress urinary incontinence
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background and Objectives A non-surgical method is being developed for treating female stress urinary incontinence by laser thermal remodeling of subsurface tissues with applied surface tissue cooling. Computer simulations of light transport, heat transfer, and thermal damage in tissue were performed, comparing transvaginal and transurethral approaches. Study Design/Materials and Methods Monte Carlo (MC) simulations provided […]
Cognitive flexibility, heart rate variability, and resilience predict fine-grained regulation of arousal during prolonged threat
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Emotion regulation in the ongoing presence of a threat is essential for adaptive behavior. Threatening situations change over time and, as a consequence, require a fine-tuned, dynamic regulation of arousal to match the current state of the environment. Constructs such as cognitive flexibility, heart rate variability, and resilience have been proposed as resources for […]
Ropivacaine infiltration analgesia
Role of ropivacaine infiltration analgesia in bilateral reduction mammaplasty via Plastique Esthétique Publication date: Available online 19 February 2016 *Source:*Annales de Chirurgie Plastique Esthétique Author(s): S. Mazouz Dorval, J. Salleron, Y. Guenane, V. Nguyen Van Nuoi, C. Ozil, M. Revol, T. Sorin IntroductionBilateral reduction mammaplasty (BRM) is a common procedure in plastic surgery. Our study aims to determine whether single-shot infiltration with ropivacaine during surgery reduces postoperative pain and decreases analgesic consumption.MethodsIn a prospective and monocent...περισσότερα »
Bilateral congenital alveolar synechiae—a rare cause of trismus
Bilateral congenital alveolar synechiae—a rare cause of trismus: AbstractCongenital alveolar synechiae is a rare anomaly mostly presenting in association with cleft palate. Owing to reduced mouth opening, feeding difficulties, and compromised airway in extreme cases along with presentation in early neonatal period, these patients present unique challenges to the surgeon as well as the anesthetist. Here, we discuss the surgical and anesthetic management of this entity in a 12-month-old female child.
Management of the Formosa Color Dust Explosion: Lessons Learned from the Treatment of 49 Mass Burn Casualty Patients at Chang Gung Memorial Hospital.
Management of the Formosa Color Dust Explosion: Lessons Learned from the Treatment of 49 Mass Burn Casualty Patients at Chang Gung Memorial Hospital.: Background: This article reports the emergency management of a mass casualty disaster occurring on June 27th, 2015 in New Taipei, Taiwan as a fire erupted over a large crowd, injuring 499 people. Lessons learned in burn care treatment and disaster preparedness are analyzed through following the specific surgical response and patient outcomes of one hospital involved in the disaster response. Methods: Information regarding the fire and... περισσότερα »
The Plastic Surgery In-Service Training Exam.
Analysis of References on the Plastic Surgery In-Service Training Exam.: Background: The Plastic Surgery In-Service Training Exam (PSITE) is a widely utilized knowledge assessment tool during plastic surgery training in the United States. This study analyzed literature supporting correct answer choices to determine highest yield sources, journal publication lag, and journal impact factors (JIF). Methods: Digital syllabi of ten consecutive PSITE administrations (2006 - 2015) were reviewed. The most referenced articles, journals, and textbooks were determined. Mean JIF and publication... περισσότερα »
Evolving Concepts of Keystone Perforator Flap: Principles of Perforator Anatomy, Design Modifications and Extended Clinical Applications.
Evolving Concepts of Keystone Perforator Flap: Principles of Perforator Anatomy, Design Modifications and Extended Clinical Applications.: Background: Keystone flaps demonstrated growing clinical applications in reconstructive surgery in the last decade. This paper highlights flap modifications and their versatility for clinical applications and management of complex defects. Methods: A retrospective chart review was conducted of consecutive patients undergoing keystone flap reconstruction at our institution from January 2012 to December 2014. Patient demographics, indications opera...περισσότερα »
The effects of the stress distribution of saddle-type implants on the alveolar bone and the structural/physical stability of implants
FEA model analysis of the effects of the stress distribution of saddle-type implants on the alveolar bone and the structural/physical stability of implants: Abstract BackgroundAs dental implants receive masticatory stress, the distribution of stress is very important to peri-implant bone homeostasis and implant survival. In this report, we created a saddle-type implant and analyzed its stability and ability to distribute stress to the surrounding bone. MethodsThe implants were designed as a saddle-type implant (SI) that wrapped around the alveolar bone, and the sizes of the sad... περισσότερα »
An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target
An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target: Author Information From the *Plastic and Reconstructive Surgery Research, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom; †Faculty of Medical and Human Sciences, Centre for Dermatology, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom; and ‡Department of Dermatology, Laboratory for Hair Research and Regenerativ... περισσότερα »
Role of Autologous Versus Homologous Cartilage in Ossicular Reconstruction: A Comparative Study
Role of Autologous Versus Homologous Cartilage in Ossicular Reconstruction: A Comparative Study: AbstractOssicular discontinuity is the most common cause of conductive hearing loss. The use of ossicular graft material in ossicular chain reconstruction significantly improves the result in hearing. This study was conducted to compare and analyze the outcome of ossicular reconstruction using autologous conchal cartilage and homologous septal cartilage in terms of hearing results and graft uptake rates. *Study design* Randomized clinical trial. Study included 100 patients visiting the ... περισσότερα »
Rare Parotid Gland Diseases
Rare Parotid Gland Diseases: [image: gr1.sml] The differential diagnosis for “rare” parotid gland diseases is broad and encompasses infectious, neoplastic, autoimmune, metabolic, and iatrogenic etiologies. The body of knowledge of parotid gland diseases has grown owing to advances in imaging and pathologic analysis and molecular technology. This article reviews rare parotid diseases, discussing the respective disease’s clinical presentation, diagnosis, imaging, pathogenesis, treatment, and prognosis.
Evaluation of Parotid Lesions
Evaluation of Parotid Lesions: [image: gr1.sml] The differential diagnosis of a parotid lesion is broad, and the otolaryngologist must consider inflammatory, neoplastic, autoimmune, traumatic, infectious, or congenital causes. A comprehensive history and physical examination, in conjunction with judicious use of radiographic imaging (MRI, computed tomography, ultrasonography, nuclear medicine studies), laboratory studies, and pathologic analysis (fine-needle aspiration, core biopsy, incisional biopsy), facilitates making an accurate diagnosis. This article reviews the key histo... περισσότερα »
Auriculotemporal Syndrome (Frey Syndrome)
Auriculotemporal Syndrome (Frey Syndrome): Frey syndrome is a common sequela of parotidectomy, and although it is not frequently manifested clinically, it can cause significant morbidity for those affected. Frey syndrome results from synkinetic autonomic reinnervation by transected postganglionic parasympathetic nerve fiber within the parotid gland to the overlying sweat glands of the skin. Many surgical techniques have been proposed to prevent the development of Frey syndrome. For those who develop clinical symptoms of Frey syndrome, objective testing can be performed with a Minor ... περισσότερα »
Parotid Gland Imaging
Parotid Gland Imaging: [image: gr1.sml] In this article, various imaging modalities are discussed for evaluation of parotid disease, from congenital to inflammatory to neoplastic etiologies. Key imaging characteristics are outlined using case examples. Introduction to biological imaging is highlighted. Additionally, image-guided biopsy techniques are illustrated for sampling parotid and parapharyngeal space lesions in a minimally invasive manner.
Facial Paralysis Reconstruction
Facial Paralysis Reconstruction: [image: gr1.sml] Facial nerve paralysis is a devastating condition arising from several causes with severe functional and psychological consequences. Given the complexity of the disease process, management involves a multispecialty, team-oriented approach. This article provides a systematic approach in addressing each specific sequela of this complex problem.
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to model >12 month speech and the oral phase of swallowing outcomes with the reconstructive metrics of tongue elevation and protrusion in patients reconstructed with the rectangle tongue template for a hemiglossectomy defect. Methods We conducted a study using 40 surviving patients (23 men, 17 women) treated between 2000 and 2012. Statistica...περισσότερα »
Consultation via telemedicine and access to operative care for patients with head and neck cancer
Consultation via telemedicine and access to operative care for patients with head and neck cancer in a Veterans Health Administration population: Abstract Background The purpose of this study was to evaluate a telemedicine model that utilizes an audiovisual teleconference as a preoperative visit. Methods Veterans Health Administration (VHA) patients with head and neck cancer at 2 remote locations were provided access to the Palo Alto Veterans Affairs (PAVA) Health Care System otolaryngology department via the telemedicine protocol: tissue diagnosis and imaging at the patient site; da...περισσότερα »
Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients
Coenzyme Q10 Levels Are Decreased in the Cerebellum of Multiple-System Atrophy Patients: [image: journal.pone.0149557.t001] by Lucia V. Schottlaender, Conceição Bettencourt, Aoife P. Kiely, Annapurna Chalasani, Viruna Neergheen, Janice L. Holton, Iain Hargreaves, Henry Houlden Background The objective of this study was to evaluate whether the levels of coenzyme Q10 (CoQ10) in brain tissue of multiple system atrophy (MSA) patients differ from those in elderly controls and in patients with other neurodegenerative diseases. Methods Flash frozen brain tissue of a series of 20 ... περισσότερα »
Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species
The post Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mS4FmW via IFTTT
Next-Generation Sequencing of a Single Domain Antibody Repertoire Reveals Quality of Phage Display Selected Candidates
by Kendrick B. Turner, Jennifer Naciri, Jinny L. Liu, George P. Anderson, Ellen R. Goldman, Dan Zabetakis Next-Generation Sequencing and bioinformatics are powerful tools for analyzing the large number of DNA sequences present in an immune library. In this work, we constructed a cDNA library of single domain antibodies from a llama immunized with staphylococcal… Continue reading Next-Generation Sequencing of a Single Domain Antibody Repertoire Reveals Quality of Phage Display Selected Candidates
Genotypic, Phenotypic and Clinical Validation of GeneXpert in Extra-Pulmonary and Pulmonary Tuberculosis in India
by Urvashi B. Singh, Pooja Pandey, Girija Mehta, Anuj K. Bhatnagar, Anant Mohan, Vinay Goyal, Vineet Ahuja, Ranjani Ramachandran, Kuldeep S. Sachdeva, Jyotish C. Samantaray Background Newer molecular diagnostics have brought paradigm shift in early diagnosis of tuberculosis [TB]. WHO recommended use of GeneXpert MTB/RIF [Xpert] for Extra-pulmonary [EP] TB; critics have since questioned its… Continue reading Genotypic, Phenotypic and Clinical Validation of GeneXpert in Extra-Pulmonary and Pulmonary Tuberculosis in India
Shell station in St Albans criticised for “sneaky” parking fines – Herts Advertiser
Herts Advertiser Shell station in St Albans criticised for “sneaky” parking fines Herts Advertiser He has problems communicating as he had part of his tongue removed after suffering mouth cancer, and is deaf. The man’s son died suddenly before Christmas, and social care services have been almost non-existent since then. Becki offered to drop off… Continue reading Shell station in St Albans criticised for “sneaky” parking fines – Herts Advertiser
Leaf Dynamics of Panicum maximum under Future Climatic Changes
by Carlos Henrique Britto de Assis Prado, Lívia Haik Guedes de Camargo-Bortolin, Érique Castro, Carlos Alberto Martinez Panicum maximum Jacq. ‘Mombaça’ (C4) was grown in field conditions with sufficient water and nutrients to examine the effects of warming and elevated CO2 concentrations during the winter. Plants were exposed to either the ambient temperature and regular… Continue reading Leaf Dynamics of Panicum maximum under Future Climatic Changes
A brother’s mourning clothes: I wanted a uniform of grief – Salon
Salon A brother’s mourning clothes: I wanted a uniform of grief Salon But after my younger sister, Jennifer, died from cancer at the age of 22, I came to see things differently. Staring at the chart, afterward, …. So when she first noticed a painful sore on her tongue no one suspected anything too sinister.… Continue reading A brother’s mourning clothes: I wanted a uniform of grief – Salon
Confirmatory Factor Analysis and Differential Relationships of the Two Subdomains of Negative Symptoms in Chronically Ill Psychotic Patients
by Annemarie P. M. Stiekema, Edith J. Liemburg, Lisette van der Meer, Stynke Castelein, Roy Stewart, Jaap van Weeghel, André Aleman, Richard Bruggeman Research suggests a two factor structure for negative symptoms in patients with psychotic disorders: social amotivation (SA) and expressive deficits (ED). Applying this two-factor structure in clinical settings may provide valuable information… Continue reading Confirmatory Factor Analysis and Differential Relationships of the Two Subdomains of Negative Symptoms in Chronically Ill Psychotic Patients
Cognitive flexibility, heart rate variability, and resilience predict fine-grained regulation of arousal during prolonged threat
Abstract Emotion regulation in the ongoing presence of a threat is essential for adaptive behavior. Threatening situations change over time and, as a consequence, require a fine-tuned, dynamic regulation of arousal to match the current state of the environment. Constructs such as cognitive flexibility, heart rate variability, and resilience have been proposed as resources for… Continue reading Cognitive flexibility, heart rate variability, and resilience predict fine-grained regulation of arousal during prolonged threat
Weight and height during adolescence may impact future risk of developing non-Hodgkin’s lymphoma
A new analysis indicates that higher body weight and taller stature during adolescence increase the risk of developing non-Hodgkin’s lymphoma (NHL), a type of cancer of the lymphatic system. The findings are published early online in Cancer, a… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1oCTkZz via IFTTT
Model Development for Risk Assessment of Driving on Freeway under Rainy Weather Conditions
by Xiaonan Cai, Chen Wang, Shengdi Chen, Jian Lu Rainy weather conditions could result in significantly negative impacts on driving on freeways. However, due to lack of enough historical data and monitoring facilities, many regions are not able to establish reliable risk assessment models to identify such impacts. Given the situation, this paper provides an… Continue reading Model Development for Risk Assessment of Driving on Freeway under Rainy Weather Conditions
Correlating thyroid cytology and histopathology: Implications for molecular testing
Correlating thyroid cytology and histopathology: Implications for molecular testing: [image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings were recorded. Using pub... περισσότερα »
Cognitive flexibility, heart rate variability, and resilience predict fine-grained regulation of arousal during prolonged threat
Abstract Emotion regulation in the ongoing presence of a threat is essential for adaptive behavior. Threatening situations change over time and, as a consequence, require a fine-tuned, dynamic regulation of arousal to match the current state of the environment. Constructs such as cognitive flexibility, heart rate variability, and resilience have been proposed as resources for adaptive emotion regulation, especially in a moment-to-moment fashion. Nevertheless, none of these constructs has been empirically related to the dynamic regulation of arousal as it unfolds over the course of... περισσότερα »
Die Lebendspende ist der beste Nierenersatz
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Terminale Niereninsuffizienz Ist bei Patienten mit einer terminalen Niereninsuffizienz die Ätiologie geklärt und sind alle medikamentösen Möglichkeiten ausgeschöpft, führt an einer Nierenersatztherapie oft kein Weg mehr vorbei. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WCHEAD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Oncogene from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oWuCmK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Oncogene from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21jW6kk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Very Brief Training for Laypeople in Hands-only CPR. Effect of Real-time Feedback
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 21 February 2016 Source:The American Journal of Emergency Medicine Author(s): Violeta González-Salvado, Felipe Fernández-Méndez, Roberto Barcala-Furelos, Carlos Peña-Gil, José Ramón González-Juanatey, Antonio Rodríguez-Núñez BackgroundBystander cardiopulmonary resuscitation (CPR) improves survival from out-of-hospital cardiac arrest, but rates and performance quality remain low. Although training laypeople is a primary educational goal, the optimal strategy […]
Attention deficit hyperactivity disorder
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Attention deficit hyperactivity disorder: A disorder in which a person is unable to control behavior due to difficulty in processing neural stimuli, accompanied by an extremely high level of motor activity. Abbreviated ADHD. ADHD can affect children and adults, but it is easiest to perceive during schooling. A child with ADHD may be extremely distractible, […]
PXR- and CAR-mediated herbal effect on human diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 22 February 2016 Source:Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms Author(s): Chenshu Xu, Min Huang, Huichang Bi The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that regulate a broad range of genes involved in drug metabolism and transport. A […]
Discussions about reproductive and sexual health among young adult survivors of cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Fertility preservation and sexual health are increasingly important as more young cancer patients survive their disease. Our aims were to describe the frequency with which reproductive and sexual health discussions occur, and to identify clinical factors associated with these discussions. Medical records of patients aged 20–39 diagnosed with solid tumors from 2008–2010 who survived […]
Consultation via telemedicine and access to operative care for patients with head and neck cancer in a Veterans Health Administration population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The purpose of this study was to evaluate a telemedicine model that utilizes an audiovisual teleconference as a preoperative visit. Methods Veterans Health Administration (VHA) patients with head and neck cancer at 2 remote locations were provided access to the Palo Alto Veterans Affairs (PAVA) Health Care System otolaryngology department via the telemedicine […]
Correlating thyroid cytology and histopathology: Implications for molecular testing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings […]
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The purpose of this study was to model >12 month speech and the oral phase of swallowing outcomes with the reconstructive metrics of tongue elevation and protrusion in patients reconstructed with the rectangle tongue template for a hemiglossectomy defect. Methods We conducted a study using 40 surviving patients (23 men, 17 women) treated […]
Discussions about reproductive and sexual health among young adult survivors of cancer
Abstract Fertility preservation and sexual health are increasingly important as more young cancer patients survive their disease. Our aims were to describe the frequency with which reproductive and sexual health discussions occur, and to identify clinical factors associated with these discussions. Medical records of patients aged 20–39 diagnosed with solid tumors from 2008–2010 who survived ≥2 years were retrospectively reviewed. Multivariate logistic models were used to explore the relationship between clinical factors and occurrence of discussions. We analyzed 427 survivors: medi...περισσότερα »
Consultation via telemedicine and access to operative care for patients with head and neck cancer in a Veterans Health Administration population
Abstract Background The purpose of this study was to evaluate a telemedicine model that utilizes an audiovisual teleconference as a preoperative visit. Methods Veterans Health Administration (VHA) patients with head and neck cancer at 2 remote locations were provided access to the Palo Alto Veterans Affairs (PAVA) Health Care System otolaryngology department via the telemedicine protocol: tissue diagnosis and imaging at the patient site; data review at PAVA; and a preoperative teleconference connecting the patient to PAVA. Operative care occurred at PAVA. Follow-up care was provi...περισσότερα »
Correlating thyroid cytology and histopathology: Implications for molecular testing
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings were recorded. Using published sensitivity and specificity, NPVs were calculated. Results Of 178 nodules (1... περισσότερα »
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] Abstract Background The purpose of this study was to model >12 month speech and the oral phase of swallowing outcomes with the reconstructive metrics of tongue elevation and protrusion in patients reconstructed with the rectangle tongue template for a hemiglossectomy defect. Methods We conducted a study using 40 surviving patients (23 men, 17 women) treated between 2000 and 2012. Statistically significant correlations of elevation and protrusion with functional outcomes were modeled with receiver operator characteristic (ROC) cu... περισσότερα »
Maximizing Outcomes for Children with Auditory Disorders: What are Children Hearing in the Classroom?
Why is assessing auditory functioning important? Hearing is a complex function. It is not safe to assume that a child has normal hearing or normal speech perception. A child may respond to some sounds but not hear other sounds. If they are missing critical information it will interfere with learning. A child needs to be able to understand speech in both quiet and in noise. A child may be fine when it is quiet, but when they are at a distance from the person who is talking or when there is competing noise, this child may have problems. from #Audiology via xlomafota13 on Inoreader h... περισσότερα »
Maximizing Outcomes for Children with Auditory Disorders: An Evidence-Based Approach to Managing Auditory Processing Disorders
Auditory processing disorder, or central auditory processing disorder (CAPD) is a breakdown in auditory abilities resulting in diminished learning or comprehension through hearing, even though peripheral hearing sensitivity is normal. Today we are not talking about children with peripheral hearing loss. We are talking about those children with normal peripheral hearing acuity who demonstrate auditory processing issues and who have been formally identified. from #Audiology via xlomafota13 on Inoreader http://ift.tt/1oCR7xd via IFTTT
Correlating thyroid cytology and histopathology: Implications for molecular testing
[image: cover.gif?v=1&s=f31d30ee0afa0d30e14f3c30] ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings were recorded. Using published sensitivity and specificity, NPVs were calculated. Results Of 178 nodules (1... περισσότερα »
Die Lebendspende ist der beste Nierenersatz
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Terminale Niereninsuffizienz Ist bei Patienten mit einer terminalen Niereninsuffizienz die Ätiologie geklärt und sind alle medikamentösen Möglichkeiten ausgeschöpft, führt an einer Nierenersatztherapie oft kein Weg mehr vorbei. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WCHEAD via IFTTT
Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Oncogene from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oWuCmK via IFTTT
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Oncogene from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21jW6kk via IFTTT
Very Brief Training for Laypeople in Hands-only CPR. Effect of Real-time Feedback
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 21 February 2016 Source:The American Journal of Emergency Medicine Author(s): Violeta González-Salvado, Felipe Fernández-Méndez, Roberto Barcala-Furelos, Carlos Peña-Gil, José Ramón González-Juanatey, Antonio Rodríguez-Núñez BackgroundBystander cardiopulmonary resuscitation (CPR) improves survival from out-of-hospital cardiac arrest, but rates and performance quality remain low. Although training laypeople is a primary educational goal, the optimal strategy […]
Attention deficit hyperactivity disorder
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Attention deficit hyperactivity disorder: A disorder in which a person is unable to control behavior due to difficulty in processing neural stimuli, accompanied by an extremely high level of motor activity. Abbreviated ADHD. ADHD can affect children and adults, but it is easiest to perceive during schooling. A child with ADHD may be extremely distractible, […]
PXR- and CAR-mediated herbal effect on human diseases
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Publication date: Available online 22 February 2016 Source:Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms Author(s): Chenshu Xu, Min Huang, Huichang Bi The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that regulate a broad range of genes involved in drug metabolism and transport. A […]
Discussions about reproductive and sexual health among young adult survivors of cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Fertility preservation and sexual health are increasingly important as more young cancer patients survive their disease. Our aims were to describe the frequency with which reproductive and sexual health discussions occur, and to identify clinical factors associated with these discussions. Medical records of patients aged 20–39 diagnosed with solid tumors from 2008–2010 who survived […]
Consultation via telemedicine and access to operative care for patients with head and neck cancer in a Veterans Health Administration population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background The purpose of this study was to evaluate a telemedicine model that utilizes an audiovisual teleconference as a preoperative visit. Methods Veterans Health Administration (VHA) patients with head and neck cancer at 2 remote locations were provided access to the Palo Alto Veterans Affairs (PAVA) Health Care System otolaryngology department via the telemedicine […]
Correlating thyroid cytology and histopathology: Implications for molecular testing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings […]
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background The purpose of this study was to model >12 month speech and the oral phase of swallowing outcomes with the reconstructive metrics of tongue elevation and protrusion in patients reconstructed with the rectangle tongue template for a hemiglossectomy defect. Methods We conducted a study using 40 surviving patients (23 men, 17 women) treated […]
Serum Amyloid A1 Secreted from UV-irradiated Keratinocytes Induces Matrix Metalloproteinase-1 in Fibroblasts through Toll-like Receptor 4
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Ultraviolet (UV) irradiation on skin triggers photoaging-related phenotypes such as formation of wrinkles. UV ray up-regulates matrix metalloproteinase-1 (MMP-1), which in turn degrades extracellular matrix proteins, mostly collagens. Serum amyloid A1 (SAA1) is an acute-phase protein of which plasma concentration increases in response to inflammation. Although the expression of SAA1 in the skin was […]
Consultation via telemedicine and access to operative care for patients with head and neck cancer in a Veterans Health Administration population
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background The purpose of this study was to evaluate a telemedicine model that utilizes an audiovisual teleconference as a preoperative visit. Methods Veterans Health Administration (VHA) patients with head and neck cancer at 2 remote locations were provided access to the Palo Alto Veterans Affairs (PAVA) Health Care System otolaryngology department via the telemedicine […]
Correlating thyroid cytology and histopathology: Implications for molecular testing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
ABSTRACT Background A gene expression classifier (GEC) has been advocated in management of some indeterminate nodules without surgery. We assessed the potential negative predictive value (NPV) of the GEC at our academic center. Methods Retrospectively, all cytologically indeterminate fine-needle aspirates (FNAs) diagnosed by University of Iowa cytopathologists over a 3-year period were identified. Histopathologic findings […]
Hemiglossectomy tongue reconstruction: Modeling of elevation, protrusion, and functional outcome using receiver operator characteristic curve
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Background The purpose of this study was to model >12 month speech and the oral phase of swallowing outcomes with the reconstructive metrics of tongue elevation and protrusion in patients reconstructed with the rectangle tongue template for a hemiglossectomy defect. Methods We conducted a study using 40 surviving patients (23 men, 17 women) treated […]
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