Preoperative Evaluation—Can We Really Make a Difference in Outcomes?
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher from Anaesthesia via ola Kala on Inoreader http://ift.tt/1RyLwkE via IFTTT
Preoperative Evaluation
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from Anaesthesia via ola Kala on Inoreader http://ift.tt/24wfWv7 via IFTTT
Preoperative Evaluation
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from Anaesthesia via ola Kala on Inoreader http://ift.tt/1RyLw4c via IFTTT
Preoperative Clinics
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Angela F. Edwards, Barbara Slawski Teaser Preoperative evaluation clinics have been shown to enhance operating room efficiency, decrease day-of-surgery cancellations, reduce hospital costs, and improve the quality of patient care. Although programs differ in staffing, structure, financial support, and daily operations, they share the common goal of preoperative risk reduction in order for patients to proceed safely through the perioperative period. Effective preoperative evaluation occurs if... περισσότερα »
Preoperative Consultations
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Stephan R. Thilen, Duminda N. Wijeysundera, Miriam M. Treggiari Teaser Preoperative consultation is an important intervention that likely has most benefits for intermediate-risk to high-risk patients undergoing major surgery. Consultation rates are likely increasing and there is significant practice variation in the use of consultation. Consultations should be available within a well-organized and coordinated process of preoperative assessment. Preoperative consults should be accessible to a... περισσότερα »
Perioperative Ethical Issues
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Arvind Chandrakantan, Tracie Saunders Teaser Shared decision-making is a paradigm of patient engagement that is assuming greater importance in the era of value-based health care. The basic tenets include patient engagement on clinical decisions, taking into account multiple factors that influence physician and patient decision-making. Understanding and reconciling diametrically opposed views of care are important tenets of shared decision-making. Because many decisions are made preoperativel...περισσότερα »
Aggressive Blutdrucksenkung bei Diabetes eher schädlich
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Wiederanstieg der kardiovaskulären Mortalität Seit Publikation der SPRINT-Studie wird wieder über strengere Ziele für die Blutdrucksenkung diskutiert. Diabetiker scheinen von einer aggressiven Therapie jedoch keinen Nutzen zu haben – im Gegenteil. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TJLUin via IFTTT
A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Summary Background Proton pump inhibitor (PPI) use is associated with an increased risk of Clostridium difficile infection (CDI), though the mechanism is unclear. PPI induced alterations to the gut microbiome may facilitate the emergence of CDI, though the effects of PPIs on gut microflora are not well characterised. Aim To compare the faecal microbiomes of […]
SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Abstract Objectives Glioblastoma multiforme (GBM) is the most aggressive brain tumour type in humans. Its poor prognosis is largely attributed to its invasiveness and high rate of recurrence. Recurring GBM is commonly resistant to chemotherapeutic drugs, making it specially difficult to treat. Recent studies have revealed that matricellular glycoprotein SPOCK1 to be upregulated in several […]
Perceptual ratings of subgroups of ataxic dysarthria.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
CONCLUSIONS & IMPLICATIONS: This study adds to the sparse, yet growing, literature to support the existence of subgroups in ataxic dysarthria. The more frequent occurrence of the instability profile is consistent with primary disruption to the timing function of the cerebellar circuit. Identification of subgroups has important clinical and research implications and further research is […]
Do children with social communication disorder have explicit knowledge of pragmatic rules they break? A comparison of conversational pragmatic ability and metapragmatic awareness.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
CONCLUSIONS & IMPLICATIONS: Findings indicate that some CwSCD have an awareness of the pragmatic rules they themselves violate in conversation. This finding suggests that, for some CwSCD, it may be beneficial for speech and language therapy to focus on improving motivation for use and better understanding of the impact of one’s own pragmatic performance on […]
Assessment of viscous energy loss and the association with three-dimensional vortex ring formation in left ventricular inflow: In vivo evaluation using four-dimensional flow MRI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Purpose To evaluate viscous energy loss and the association with three-dimensional (3D) vortex ring formation in left ventricular (LV) blood flow during diastolic filling. Theory and Methods Thirty healthy volunteers were compared with 32 patients with corrected atrioventricular septal defect as unnatural mitral valve morphology and inflow are common in these patients. 4DFlow MRI was […]
Fitting methods for intravoxel incoherent motion imaging of prostate cancer on region of interest level: Repeatability and gleason score prediction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Purpose To evaluate different fitting methods for intravoxel incoherent motion (IVIM) imaging of prostate cancer in the terms of repeatability and Gleason score prediction. Methods Eighty-one patients with histologically confirmed prostate cancer underwent two repeated 3 Tesla diffusion-weighted imaging (DWI) examinations performed using 14 b-values in the range of 0–500 s/mm2 and diffusion time of […]
MR fingerprinting using the quick echo splitting NMR imaging technique
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Purpose The purpose of the study is to develop a quantitative method for the relaxation properties with a reduced radio frequency (RF) power deposition by combining magnetic resonance fingerprinting (MRF) technique with quick echo splitting NMR imaging technique (QUEST). Methods A QUEST-based MRF sequence was implemented to acquire high-order echoes by increasing the gaps between […]
A new paramagnetically shifted imaging probe for MRI
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Purpose To develop and characterize a new paramagnetic contrast agent for molecular imaging by MRI. Methods A contrast agent was developed for direct MRI detection through the paramagnetically shifted proton magnetic resonances of two chemically equivalent tert-butyl reporter groups within a dysprosium(III) complex. The complex was characterized in phantoms and imaged in physiologically intact mice […]
Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Purpose To develop and optimize a multislice glycosaminoglycan (GAG) chemical exchange saturation transfer (GagCEST) sequence for volumetric imaging of articular cartilage, and to validate the sequence against T1ρ relaxation times in whole joint imaging of tibiotalar cartilage. Methods Ex vivo experiments were used to observe the effect of the number of partitions and shot TR […]
Understanding and Treating Severe and Profound Hearing Loss
Oticon has a history of creating excellent solutions for patients with severe-to-profound hearing loss. With the release of Oticon Dynamo, Sensei Super Power, and the Plus Power products in our performance line categories, we have again raised the ba from #ENT via xlomafota13 on Inoreader http://ift.tt/1XUleMt via IFTTT
Robotic-assisted surgery for the management of velopharyngeal insufficiency and nasopharyngeal stenosis
from #ENT via xlomafota13 on Inoreader http://ift.tt/1QeOR8m via IFTTT
Dendritic cells activated by interferon-γ/STAT1 express interleukin-31 receptor and release pro-inflammatory mediators upon interleukin-31 treatment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Journal of immunology (Baltimore, Md. : 1950) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RepAZJ via IFTTT
Correlations in Liquid Water for the TIP3P-Ewald, TIP4P-2005, TIP5P-Ewald and SWM4-NDP Models
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
The Journal of chemical physics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OH155w via IFTTT
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Journal of immunology (Baltimore, Md. : 1950) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pjJQT0 via IFTTT
An Smc3 Acetylation Cycle Is Essential for Establishment of Sister Chromatid Cohesion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Molecular cell from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OH17KE via IFTTT
A pilot randomised controlled trial to assess the utility of an e‐learning package that trains users in adverse drug reaction causality
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
The International Journal of Pharmacy Practice from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pjJQmf via IFTTT
Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Journal of Thrombosis and Haemostasis from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OH14OV via IFTTT
Wild bird‐associated C ampylobacter jejuni isolates are a consistent source of human disease, in Oxford shire, United Kingdom
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Environmental Microbiology Reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pjJOdP via IFTTT
Functional analysis of drug resistance‐associated mutations in the T rypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Molecular Microbiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OH14ON via IFTTT
Parallel trait adaptation across opposing thermal environments in experimental Drosophila melanogaster populations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Evolution; International Journal of Organic Evolution from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pjJQ5G via IFTTT
The Influence of Cognitive Factors on Outcomes with Frequency Lowering
IntroductionSince frequency lowering technology has become commercially available in modern digital hearing aids, researchers have set out to determine what benefits this technology could provide hearing-impaired patients. There is an abundance from #Audiology via xlomafota13 on Inoreader http://ift.tt/1Sbuc7M via IFTTT
Understanding and Treating Severe and Profound Hearing Loss
Oticon has a history of creating excellent solutions for patients with severe-to-profound hearing loss. With the release of Oticon Dynamo, Sensei Super Power, and the Plus Power products in our performance line categories, we have again raised the ba from #Audiology via xlomafota13 on Inoreader http://ift.tt/1XUleMt via IFTTT
Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
[image: cover.gif?v=1&s=05b840a28bed2b1c909051a8] ABSTRACT The molecular mechanisms underlying the serrated pathway of colorectal tumorigenesis, particularly those related to traditional serrated adenomas (TSAs), are still poorly understood. In this study, we analyzed genetic alterations in 188 colorectal polyps, including hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous adenomas by using targeted next-generation sequencing and reverse transcription PCR. Our analyses showed that most TSAs (71%) contained genetic alterations... περισσότερα »
Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
[image: cover.gif?v=1&s=05b840a28bed2b1c909051a8] Abstract Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver regeneration *in vivo*. To further investigate the role of this pathway we examined their expression in human fibrotic liver disease and the effect of pathway deficiency in a murine model of liver fibrosis. The expression of Fn14 and TWEAK in normal and diseased human and mouse liver tissue and primary human hepatic stellate cells (HSC) were investigated by qPCR, weste... περισσότερα »
Vegf-d promotes pulmonary oedema in hyperoxic acute lung injury
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
[image: cover.gif?v=1&s=05b840a28bed2b1c909051a8] ABSTRACT Leakage of fluid from blood vessels, leading to oedema, is a key feature of many diseases including hyperoxic acute lung injury (HALI) which can occur when patients are ventilated with high concentrations of oxygen (hyperoxia). The molecular mechanisms driving vascular leak and oedema in HALI are poorly understood. VEGF-D is a protein that promotes blood vessel leak and oedema when overexpressed in tissues, but the role of endogenous VEGF-D in pathological oedema was unknown. To address these issues, we exposed *Vegfd*-de... περισσότερα »
The Influence of Cognitive Factors on Outcomes with Frequency Lowering
IntroductionSince frequency lowering technology has become commercially available in modern digital hearing aids, researchers have set out to determine what benefits this technology could provide hearing-impaired patients. There is an abundance from #Audiology via xlomafota13 on Inoreader http://ift.tt/1Sbuc7M via IFTTT
Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma
ABSTRACT The molecular mechanisms underlying the serrated pathway of colorectal tumorigenesis, particularly those related to traditional serrated adenomas (TSAs), are still poorly understood. In this study, we analyzed genetic alterations in 188 colorectal polyps, including hyperplastic polyps, sessile serrated adenomas/polyps (SSA/Ps), TSAs, tubular adenomas, and tubulovillous adenomas by using targeted next-generation sequencing and reverse transcription PCR. Our analyses showed that most TSAs (71%) contained genetic alterations in WNT pathway components. In particular, *PTPRK-R... περισσότερα »
Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation
Abstract Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver regeneration *in vivo*. To further investigate the role of this pathway we examined their expression in human fibrotic liver disease and the effect of pathway deficiency in a murine model of liver fibrosis. The expression of Fn14 and TWEAK in normal and diseased human and mouse liver tissue and primary human hepatic stellate cells (HSC) were investigated by qPCR, western blotting and immunohistochemistry. In addition, t... περισσότερα »
Vegf-d promotes pulmonary oedema in hyperoxic acute lung injury
ABSTRACT Leakage of fluid from blood vessels, leading to oedema, is a key feature of many diseases including hyperoxic acute lung injury (HALI) which can occur when patients are ventilated with high concentrations of oxygen (hyperoxia). The molecular mechanisms driving vascular leak and oedema in HALI are poorly understood. VEGF-D is a protein that promotes blood vessel leak and oedema when overexpressed in tissues, but the role of endogenous VEGF-D in pathological oedema was unknown. To address these issues, we exposed *Vegfd*-deficient mice to hyperoxia. The resulting pulmonary o...περισσότερα »
A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors
[image: cover.gif?v=1&s=1bb6d2e8a0aa28ed080b3d6f] Summary Background Proton pump inhibitor (PPI) use is associated with an increased risk of *Clostridium difficile* infection (CDI), though the mechanism is unclear. PPI induced alterations to the gut microbiome may facilitate the emergence of CDI, though the effects of PPIs on gut microflora are not well characterised. Aim To compare the faecal microbiomes of long-term PPI users to those with no history of PPI use. Methods We used a population-based database to identify individuals with ≥5 years of continuous PPI use along with...περισσότερα »
Preoperative Laboratory Testing
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Matthias Bock, Gerhard Fritsch, David L. Hepner Teaser Routine preoperative testing is not cost-effective, because it is unlikely to identify significant abnormalities. Abnormal findings from routine testing are more likely to be false positive, are costly to pursue, introduce a new risk, increase the patient's anxiety, and are inconvenient to the patient. Abnormal findings rarely alter the surgical or anesthetic plan, and there is usually no association between perioperative complications a... περισσότερα »
Preoperative Assessment of the Patient with Cardiac Disease Undergoing Noncardiac Surgery
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher Teaser The American College of Cardiology/American Heart Association has published Guidelines on Perioperative Evaluation. Preoperative evaluation should focus on identifying patients with symptomatic and asymptomatic coronary artery disease. The guidelines advocate using the American College of Surgeons National Surgical Quality Improvement Project Risk Index to determine perioperative risk. Diagnostic testing should be reserved for those at increased risk with poor exercise...περισσότερα »
Preoperative Evaluation
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Anand Lakshminarasimhachar, Gerald W. Smetana Teaser Postoperative pulmonary complications (PPCs) are common after major non-thoracic surgery and associated with significant morbidity and high cost of care. A number of risk factors are strong predictors of PPCs. The overall goal of the preoperative pulmonary evaluation is to identify these potential, patient and procedure-related risks and optimize the health of the patients before surgery. A thorough clinical examination supported by approp... περισσότερα »
Stratification and Risk Reduction of Perioperative Acute Kidney Injury
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Selma Ishag, Charuhas V. Thakar Teaser Perioperative acute kidney injury (AKI) is associated with an increased morbidity and mortality. The incidence of AKI varies depending on preoperative risk factors and the surgical setting. Preoperative risk stratification is critical for informed consent and perioperative planning. Perioperative renal protection strategies are potentially invaluable in the prevention of AKI. Current advances in the development of biomarkers may offer the opportunity fo... περισσότερα »
The Development of Surveillance Systems
Surveillance systems in public health practice have increased in number and sophistication with advances in data collection, analysis, and communication. When the Communicable Disease Center (now the Centers for Disease Control and Prevention) was founded some 70 years ago, *surveillance* referred to the close observation of individuals with suspected smallpox, plague, or cholera. Alexander Langmuir, head of the Epidemiology Branch, redefined surveillance as the epidemiology-based critical factor in infectious disease control. I joined Langmuir as assistant chief in 1955 and was a...περισσότερα »
A comparison of the gut microbiome between long-term users and non-users of proton pump inhibitors
[image: cover.gif?v=1&s=1bb6d2e8a0aa28ed080b3d6f] Summary Background Proton pump inhibitor (PPI) use is associated with an increased risk of *Clostridium difficile* infection (CDI), though the mechanism is unclear. PPI induced alterations to the gut microbiome may facilitate the emergence of CDI, though the effects of PPIs on gut microflora are not well characterised. Aim To compare the faecal microbiomes of long-term PPI users to those with no history of PPI use. Methods We used a population-based database to identify individuals with ≥5 years of continuous PPI use along with...περισσότερα »
Robotic-assisted surgery for the management of velopharyngeal insufficiency and nasopharyngeal stenosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1QeOR8m via IFTTT
Moffett’s solution and the new 2015 UK drug-driving laws: the case for consenting patients for its use
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1QeOk6f via IFTTT
Copyright
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RyLx8s via IFTTT
Contributors
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/24wfVqY via IFTTT
Contents
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RyLysS via IFTTT
Forthcoming Issues
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/24wfVay via IFTTT
Preoperative Evaluation—Can We Really Make a Difference in Outcomes?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RyLwkE via IFTTT
Preoperative Evaluation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/24wfWv7 via IFTTT
Preoperative Evaluation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RyLw4c via IFTTT
Preoperative Clinics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 51 δευτερόλεπτα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Angela F. Edwards, Barbara Slawski Teaser Preoperative evaluation clinics have been shown to enhance operating room efficiency, decrease day-of-surgery cancellations, reduce hospital costs, and improve the quality of patient care. Although programs differ in staffing, structure, financial support, and daily operations, they share the […]
Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy
Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy: Abstract: Background: Induction of specific immunoglobulin G4 (sIgG4) response (so-called blocking antibodies) in patients who receive specific immunotherapy (SIT) has been observed for many years. Although many other mechanisms have been identified as key regulators of immunologic processes in… Continue reading Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy
A new paramagnetically shifted imaging probe for MRI
Purpose To develop and characterize a new paramagnetic contrast agent for molecular imaging by MRI. Methods A contrast agent was developed for direct MRI detection through the paramagnetically shifted proton magnetic resonances of two chemically equivalent tert-butyl reporter groups within a dysprosium(III) complex. The complex was characterized in phantoms and imaged in physiologically intact mice… Continue reading A new paramagnetically shifted imaging probe for MRI
SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance
Abstract Objectives Glioblastoma multiforme (GBM) is the most aggressive brain tumour type in humans. Its poor prognosis is largely attributed to its invasiveness and high rate of recurrence. Recurring GBM is commonly resistant to chemotherapeutic drugs, making it specially difficult to treat. Recent studies have revealed that matricellular glycoprotein SPOCK1 to be upregulated in several… Continue reading SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance
The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis
The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis: Abstract: Background: An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy. Objective: To compare the clinical efficacy of SLIT with vitamin D supplementation with placebo in children with allergic rhinitis. Secondary end points included lung… Continue reading The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis
Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho
Purpose To develop and optimize a multislice glycosaminoglycan (GAG) chemical exchange saturation transfer (GagCEST) sequence for volumetric imaging of articular cartilage, and to validate the sequence against T1ρ relaxation times in whole joint imaging of tibiotalar cartilage. Methods Ex vivo experiments were used to observe the effect of the number of partitions and shot TR… Continue reading Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson’s Disease: Diagnostic Links
ABSTRACT Lysosomal impairment is increasingly recognized as a central event in the pathophysiology of PD. Genetic associations between lysosomal storage disorders, including Gaucher disease and PD, highlight common risk factors and pathological mechanisms. Because the autophagy–lysosomal system is involved in the intralysosomal hydrolysis of dysfunctional proteins, lysosomal impairment may contribute to α-synuclein aggregation in PD.… Continue reading Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson’s Disease: Diagnostic Links
SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis
SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis: Abstract: Background: Allergy immunotherapy is a treatment option for allergic rhinoconjunctivitis (ARC). It is unique compared with pharmacotherapy in that it modifies the immunologic pathways that elicit an allergic response. The SQ Timothy grass sublingual immunotherapy (SLIT) tablet is approved in… Continue reading SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis
Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid–attenuated T1-weighted 3D turbo spin echo
Purpose Although three-dimensional (3D) turbo spin echo (TSE) with variable flip angles has proven to be useful for intracranial vessel wall imaging, it is associated with inadequate suppression of cerebrospinal fluid (CSF) signals and limited spatial coverage at 3 Tesla (T). This work aimed to modify the sequence and develop a protocol to achieve whole-brain,… Continue reading Whole-brain intracranial vessel wall imaging at 3 Tesla using cerebrospinal fluid–attenuated T1-weighted 3D turbo spin echo
Sleep apnea
Sleep apnea: The temporary stoppage of breathing during sleep, often resulting in daytime sleepiness. Apnea is a Greek word that means «want of breath.» The most common form of sleep apnea is obstructive sleep apnea. In obstructive sleep apnea, the muscles of the soft palate around the base of the tongue and the uvula relax,… Continue reading Sleep apnea
Approach to evaluation and management of a patient with multiple food allergies
Approach to evaluation and management of a patient with multiple food allergies: Abstract: Background: Diagnosing food allergy is often challenging, and validated testing modalities are mostly limited to immunoglobulin E (IgE)-mediated reactions to foods. Use of food-specific IgE tests and skin prick tests in individuals without a history that supports an IgE-mediated reaction to the… Continue reading Approach to evaluation and management of a patient with multiple food allergies
Anesthesiology Clinics : Preoperative Evaluation
Preoperative Evaluation Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman Copyright Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Contributors Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Contents Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Forthcoming Issues Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Preoperative Evaluati... περισσότερα »
EMERGENCY PERIPARTUM HYSTERECTOMY: INCIDENCE, INDICATIONS AND FETOMATERNAL OUTCOME IN A TERTIARY CARE HOSPITAL
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
2016-02-28T23-03-01Z *Source:* International Journal of Current Research and Review Saima Wani, Perveena Fareed, Yasmeena Gull, Neha Mahajan. Objectives: The objectives of this study were to determine the incidence, maternal characteristics, indications and the maternal and perinatal outcome of emergency peripartum hysterectomies done in the Department of Obstetrics and Gynecology Government Medical College Srinagar. Study Design: This was a retrospective descriptive study done from January 2011-December 2013 over a three year period. Results: The incidence of peripartum hysterectom... περισσότερα »
EVALUATION OF COLOR AND LIGHTING PREFERENCES IN ARCHITECTS’ OFFICES FOR ENHANCING PRODUCTIVITY
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
2016-02-28T23-03-01Z *Source:* International Journal of Current Research and Review Zahra Poursafar, Nandineni Rama Devi, Lewlyn L. R. Rodrigues. Background: Knowledge of design basics is key to the successful planning and implementation of any interior design project. The elements and principles of design represent general, universal ideas that refer to every aspect of design. Aim: This paper is focusing on occupants Preferences regarding to Color and Lighting in the Architects offices in Iran and India to increase the level of personalization in work environment and improving the ...περισσότερα »
Copyright
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1RyLx8s via IFTTT
Contributors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/24wfVqY via IFTTT
Contents
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1RyLysS via IFTTT
Forthcoming Issues
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/24wfVay via IFTTT
Preoperative Evaluation—Can We Really Make a Difference in Outcomes?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1RyLwkE via IFTTT
Preoperative Evaluation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/24wfWv7 via IFTTT
Preoperative Evaluation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Debra Domino Pulley, Deborah C. Richman from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1RyLw4c via IFTTT
Preoperative Clinics
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Angela F. Edwards, Barbara Slawski Teaser Preoperative evaluation clinics have been shown to enhance operating room efficiency, decrease day-of-surgery cancellations, reduce hospital costs, and improve the quality of patient care. Although programs differ in staffing, structure, financial support, and daily operations, they share the common goal of preoperative risk reduction in order for patients to proceed safely through the perioperative period. Effective preoperative evaluation occurs if... περισσότερα »
Preoperative Consultations
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Stephan R. Thilen, Duminda N. Wijeysundera, Miriam M. Treggiari Teaser Preoperative consultation is an important intervention that likely has most benefits for intermediate-risk to high-risk patients undergoing major surgery. Consultation rates are likely increasing and there is significant practice variation in the use of consultation. Consultations should be available within a well-organized and coordinated process of preoperative assessment. Preoperative consults should be accessible to a... περισσότερα »
Perioperative Ethical Issues
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Arvind Chandrakantan, Tracie Saunders Teaser Shared decision-making is a paradigm of patient engagement that is assuming greater importance in the era of value-based health care. The basic tenets include patient engagement on clinical decisions, taking into account multiple factors that influence physician and patient decision-making. Understanding and reconciling diametrically opposed views of care are important tenets of shared decision-making. Because many decisions are made preoperativel...περισσότερα »
Preoperative Laboratory Testing
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Matthias Bock, Gerhard Fritsch, David L. Hepner Teaser Routine preoperative testing is not cost-effective, because it is unlikely to identify significant abnormalities. Abnormal findings from routine testing are more likely to be false positive, are costly to pursue, introduce a new risk, increase the patient's anxiety, and are inconvenient to the patient. Abnormal findings rarely alter the surgical or anesthetic plan, and there is usually no association between perioperative complications a... περισσότερα »
Preoperative Assessment of the Patient with Cardiac Disease Undergoing Noncardiac Surgery
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher Teaser The American College of Cardiology/American Heart Association has published Guidelines on Perioperative Evaluation. Preoperative evaluation should focus on identifying patients with symptomatic and asymptomatic coronary artery disease. The guidelines advocate using the American College of Surgeons National Surgical Quality Improvement Project Risk Index to determine perioperative risk. Diagnostic testing should be reserved for those at increased risk with poor exercise...περισσότερα »
Preoperative Evaluation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Anand Lakshminarasimhachar, Gerald W. Smetana Teaser Postoperative pulmonary complications (PPCs) are common after major non-thoracic surgery and associated with significant morbidity and high cost of care. A number of risk factors are strong predictors of PPCs. The overall goal of the preoperative pulmonary evaluation is to identify these potential, patient and procedure-related risks and optimize the health of the patients before surgery. A thorough clinical examination supported by approp... περισσότερα »
Stratification and Risk Reduction of Perioperative Acute Kidney Injury
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Selma Ishag, Charuhas V. Thakar Teaser Perioperative acute kidney injury (AKI) is associated with an increased morbidity and mortality. The incidence of AKI varies depending on preoperative risk factors and the surgical setting. Preoperative risk stratification is critical for informed consent and perioperative planning. Perioperative renal protection strategies are potentially invaluable in the prevention of AKI. Current advances in the development of biomarkers may offer the opportunity fo... περισσότερα »
Perioperative Approach to Anticoagulants and Hematologic Disorders
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Jisu Kim, Richard Huh, Amir K. Jaffer Teaser Hematologic disorders and patients on anticoagulants or at risk for venous thromboembolism encompass a broad array of diagnoses, which can potentially complicate perioperative planning and management. This article addresses both bleeding and clotting concerns as well as special hematologic issues. from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1oIlgL4 via IFTTT
Preoperative Anemia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 57 δευτερόλεπτα
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ankit J. Kansagra, Mihaela S. Stefan Teaser Previously undiagnosed anemia is often identified during routine assessment of surgical patients. Although studies suggest that perioperative anemia is associated with worse outcomes and a strong predictor for postoperative red cell transfusions, anemia is frequently ignored. Preoperative optimization of patients undergoing elective surgical procedures associated with significant blood loss, along with strategies to minimize intraoperative blood lo... περισσότερα »
Anaphylaxis to polymyxin B–trimethoprim eye drops
A multicenter comparison of *polymyxin B *sulfate/*trimethoprim *ophthalmic solution and moxifloxacin in the speed of clinical efficacy for the treatment of bacterial … *DB Granet, M Dorfman, D Stroman… - Journal of pediatric …, 2008 - healio.com* *... Eye discharge continued for 5 days after the initiation of treatment. ... After 48 hours of treatment,moxifloxacin and polymyxin/trimethoprim completely eradicated H. influenzae. Additionally,although H. influenzae type B (HiB) and pneumococcal conjugate vaccines have been ...* *Γίνεται αναφορά σε 34 Σχετικά άρθρα Όλες οι 7 εκδοχές ... περισσότερα »
β-lactam hypersensitivity investigation
Impact of an extended challenge on the effectiveness of via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online 26 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Roy Ratzon, Avner Reshef, Ori Efrati, Michal Deutch, Rinat Forschmidt, Tali Cukierman-Yaffe, Ron Kenett, Mona Iancovici Kidon BackgroundDrug provocation tests (DPTs) are the gold standard in the diagnosis of β-lactam hypersensitivity. However, no consensus exists on the need for extended provocation tests, even though the effectiveness of the short DPT ... περισσότερα »
Understanding and Treating Severe and Profound Hearing Loss
Oticon has a history of creating excellent solutions for patients with severe-to-profound hearing loss. With the release of Oticon Dynamo, Sensei Super Power, and the Plus Power products in our performance line categories, we have again raised the ba from #Audiology via xlomafota13 on Inoreader http://ift.tt/1XUleMt via IFTTT
The Influence of Cognitive Factors on Outcomes with Frequency Lowering
IntroductionSince frequency lowering technology has become commercially available in modern digital hearing aids, researchers have set out to determine what benefits this technology could provide hearing-impaired patients. There is an abundance from #Audiology via ola Kala on Inoreader http://ift.tt/1Sbuc7M via IFTTT
Understanding and Treating Severe and Profound Hearing Loss
Oticon has a history of creating excellent solutions for patients with severe-to-profound hearing loss. With the release of Oticon Dynamo, Sensei Super Power, and the Plus Power products in our performance line categories, we have again raised the ba from #Audiology via ola Kala on Inoreader http://ift.tt/1XUleMt via IFTTT
A prediction model of severe reaction in boiled egg challenges
Development of via Allergology International Publication date: Available online 26 February 2016 *Source:*Allergology International Author(s): Shiro Sugiura, Teruaki Matsui, Tomoko Nakagawa, Kemal Sasaki, Joon Nakata, Naoyuki Kando, Komei Ito BackgroundWe have proposed a new scoring system (Anaphylaxis SCoring Aichi: ASCA) for a quantitative evaluation of the anaphylactic reaction that is observed in an oral food challenge (OFC). Furthermore, the TS/Pro (Total Score of ASCA/cumulative protein dose) can be a marker to represent the overall severity of a food allergy. We aimed to develo... περισσότερα »
Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis
Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis: F8-IL-4 is a recently developed immunocytokine which delivers IL-4 to sites of inflammation by targeting the neovasculature. We previously reported that F8-IL-4, in combination with dexamethasone, provides a durable therapy in mice with collagen-induced arthritis (CIA). Therefore, the objective of this study was to identify the mechanism by which IL-4 and dexamethasone combination therapy provides long-lasting disease remission. F8-IL-4 a...περισσότερα »
Chronic pruritic dermatitis and peripheral eosinophilia in a 42-year-old man
Chronic pruritic dermatitis and peripheral eosinophilia in a 42-year-old man: Abstract:Chronic pruritic dermatitis with or without accompanying peripheral eosinophilia can be caused by a vast array of underlying disorders broadly classified as allergic/immunologic, infectious, or neoplastic. An organized and thorough work up is crucial in order to arrive at a definitive diagnosis enabling appropriate treatment. We present the case of a 42-year-old man with a history of chronic pruritic dermatitis and peripheral eosinophilia in a patient-oriented, problem-solving format including... περισσότερα »
Parental perception of efficacy of antihistamines for pruritus in pediatric atopic dermatitis
Parental perception of efficacy of antihistamines for pruritus in pediatric atopic dermatitis: Abstract:Background: Clinicians have previously prescribed antihistamines for relief of atopic dermatitis (AD) associated pruritus. The use of antihistamines in AD has recently received less emphasis from newly published practice parameters that currently only recommend short-term, intermittent use of first-generation antihistamines to induce sleep in patients with AD. Objective: Our study aimed to determine parents' perception of the usefulness of antihistamines in reducing their ... περισσότερα »
Th1/Th2/Th17 cells imbalance in patients with asthma with and without psychological symptoms
Th1/Th2/Th17 cells imbalance in patients with asthma with and without psychological symptoms: Abstract:Background: The prevalence of psychological symptoms such as anxiety and depression among patients with asthma is high. Both asthma and psychological symptoms are characterized by immune inflammation in which CD4+ T cells play a role. Objective: To investigate whether T-helper (Th) 1, Th2, and Th17 cells imbalance exists in patients with asthma and with and in patients without psychological symptoms. Methods: The messenger RNA (mRNA) expression of T-box 21 (T-bet), GATA ...περισσότερα »
Evaluation of allergic sensitivity to Acanthamoeba allergen in patients with chronic cough
Evaluation of allergic sensitivity to Acanthamoeba allergen in patients with chronic cough: Abstract:Background: *Acanthamoeba* and their proteins can elicit severe allergic airway inflammation in experimental mice. Objective: Although *Acanthamoeba* can induce severe allergic airway inflammation in mice, there is no allergenicity data for humans. Methods: We performed a skin-prick test on 65 patients with chronic cough by using 54 previously known allergens and*Acanthamoeba* excretory-secretory proteins and enzyme-linked immunosorbent assay on 34 patients to evaluate *Ac... περισσότερα »
Respiratory disease : Cough as a key symptom
Respiratory disease in the Asia-Pacific region: Cough as a key symptom: Abstract:Background: Respiratory diseases represent a significant impact on health care. A cross-sectional, multicountry (India, Korea, Malaysia, Singapore, Taiwan, and Thailand) observational study was conducted to investigate the proportion of adult patients who received care for a primary diagnosis of asthma, allergic rhinitis (AR), chronic obstructive pulmonary disease (COPD), or rhinosinusitis. Objective: To determine the proportion of patients who received care for asthma, AR, COPD, and rhinosinusi... περισσότερα »
Beclomethasone Dipropionate Nasal Aerosol in Patients with Perennial Allergic Rhinitis (BALANCE) study: 6-month results
Beclomethasone Dipropionate Nasal Aerosol in Patients with Perennial Allergic Rhinitis (BALANCE) study: 6-month results: Abstract:Background: Perennial allergic rhinitis (PAR) exerts significant quality-of-life and economic burdens on society. Beclomethasone dipropionate (BDP) nasal aerosol is the first nonaqueous, hydrofluoroalkane-propelled intranasal corticosteroid approved for patients in the United States to treat PAR and seasonal allergic rhinitis. Objective: To evaluate real-world effectiveness of BDP nasal aerosol from the patient's perspective by using a postmarketi... περισσότερα »
Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy
Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy: Abstract:Background: Induction of specific immunoglobulin G4 (sIgG4) response (so-called blocking antibodies) in patients who receive specific immunotherapy (SIT) has been observed for many years. Although many other mechanisms have been identified as key regulators of immunologic processes in peripheral tolerance to allergens, the rise of sIgG4 during immunotherapy, together with the clinical improvement, is still believed to be one of the most important mec... περισσότερα »
The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis
The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis: Abstract:Background: An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy. Objective: To compare the clinical efficacy of SLIT with vitamin D supplementation with placebo in children with allergic rhinitis. Secondary end points included lung function, exhaled nitric oxide concentration, methacholine bronchial provocation test, and serum level of calcifediol (25[OH]D). Methods: Fifty children, ages 5‐12 years... περισσότερα »
SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis
SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis: Abstract:Background: Allergy immunotherapy is a treatment option for allergic rhinoconjunctivitis (ARC). It is unique compared with pharmacotherapy in that it modifies the immunologic pathways that elicit an allergic response. The SQ Timothy grass sublingual immunotherapy (SLIT) tablet is approved in North America and throughout Europe for the treatment of adults and children (≥5 years old) with grass pollen‐induced ARC. Objective: The clinical evide... περισσότερα »
Approach to evaluation and management of a patient with multiple food allergies
Approach to evaluation and management of a patient with multiple food allergies: Abstract:Background: Diagnosing food allergy is often challenging, and validated testing modalities are mostly limited to immunoglobulin E (IgE)-mediated reactions to foods. Use of food-specific IgE tests and skin prick tests in individuals without a history that supports an IgE-mediated reaction to the specific food being tested diminishes the predictive capabilities of the test. Objective: To review the literature regarding evaluation of patients with a concern for multiple food allergies and... περισσότερα »
The morbidity and cost of vocal cord dysfunction misdiagnosed as asthma
The morbidity and cost of vocal cord dysfunction misdiagnosed as asthma: Abstract:Background: Vocal cord dysfunction (VCD) is frequently misdiagnosed and mistreated as asthma, which leads to morbidity secondary to unnecessary medication use and increased health care utilization. Objective: We identified discriminating symptoms and triggers, and analyzed the costs, morbidity, and health care burden associated with misdiagnosis of VCD as asthma. We sought to determine if current measures of asthma control contributed to these findings. We evaluated if a simple set of breathing ...περισσότερα »
Imaging in autoimmune diseases in the central nervous system
In vivo via Allergology International Publication date: Available online 28 February 2016 *Source:*Allergology International Author(s): Naoto Kawakami Intravital imaging is becoming more popular and is being used to visualize cellular motility and functions. In contrast to in vitro analysis, which resembles in vivo analysis, intravital imaging can be used to observe and analyze cells directly in vivo. In this review, I will summarize recent imaging studies of autoreactive T cell infiltration into the central nervous system (CNS) and provide technical background. During their in vivo ... περισσότερα »
Scapular osteocutaneous free flap for total lower lip and mandible reconstruction
Scapular osteocutaneous free flap for total lower lip and mandible reconstruction: Purpose Total lower lip and mandible defects following tumor resection present challenging reconstructions. The use of dual free flaps leads to increased donor-site morbidity and risk of flap failure. We present a single scapular free flap approach with unique use of osteotomies for lip reconstruction in a small series of patients. Methods: A case series was conducted from 2007 to 2012 on three patients with squamous cell carcinoma of the oral cavity requiring large resection. Patients ranged in age ... περισσότερα »
Plant compounds as active photo protectants in sunscreens
Plant compounds as active photo protectants in sunscreens: Abstract Excessive exposure to the sun's radiation is the major exogenous mediator of skin damage, which accelerates skin aging and increases the risk of developing skin cancer. Compounds with photoprotectant activity are extremely useful for decreasing the effect of ultraviolet (UV) radiation on the skin; however, numerous sun filters, especially organic sunscreens, are allergenic. Therefore, the development of formulations containing plant extracts, which may be potentially safer, is extensively being explored. Plant-base...περισσότερα »
The Effect of Epigallocatechin Gallate on Flap Viability of Rat Perforator Abdominal Flaps
The Effect of Epigallocatechin Gallate on Flap Viability of Rat Perforator Abdominal Flaps: J reconstr Microsurg DOI: 10.1055/s-0036-1571807 Background Epigallocatechin gallate (EGCG) is a substance abundant in green tea. In this study, the effects of EGCG on perforator flap viability were investigated. Methods A total of 40 rats were assigned to four groups of 10 each. In each subject, a 4 × 6 cm abdominal skin flap was raised and adapted back onto its place. In the control group, no further procedures were taken. In the flap group, 40 mg/kg/d EGCG was injected into the flap. In ... περισσότερα »
Supermicrosurgery simulation using prosthetic lymphatic channels
Supermicrosurgery simulation using prosthetic lymphatic channels: Supermicrosurgery refers to that subset of operative microsurgery which involves the dissection and repair of structures less than 0.8 mm. Although practiced for many years in countries such as Japan, its use has not been as widespread worldwide, mainly because of a lack of training opportunities for surgeons’ in units where supermicrosurgery procedures are not normally featured or when opportunities to train both inside and outside the operating room setting are not available. In this short communication, we advocate... περισσότερα »
Botulinum toxin in the treatment of orofacial pain
Effects of *botulinum toxin *type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats *S Ibragić, I Matak, A Dračić, A Smajlović… - Neuroscience …, 2016 - Elsevier* *... Clostridium botulinum, Clostridium barati, Clostridium argentinense), are the most potent toxinsknown [40 ... of saline-diluted BTX-A therapeutic preparation (Botox ® , INN: Clostridium botulinumtype A ... model of formalin-induced orofacial pain 7 days post peripheral toxin injection. ...* *Παράθεση Αποθήκευση* *[PDF] από jyoungpharm.org* [PDF] *Botulinum toxin*... περισσότερα »
The recurrence rate of keratocystic odontogenic tumours (KCOTs) treated by enucleation and the application of Carnoy's solution
Results of the treatment of keratocystic odontogenic tumours using enucleation and treatment of the residual bony defect with Carnoy's solution via Oral and Maxillofacial Surgery Publication date: Available online 26 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): Y.Y. Leung, S.L. Lau, K.Y.Y. Tsoi, H.L. Ma, C.L. Ng This retrospective study aimed to investigate the recurrence rate of keratocystic odontogenic tumours (KCOTs) treated by enucleation and the application of Carnoy's solution, and to assess the surgical morbidities associated with thi...περισσότερα »
Pharmacological Targeting of Histamine H4 Receptor in Periodontal Disease
Pharmacological Targeting of Histamine H4 Receptor in Periodontal Disease: [image: cover.gif?v=1&s=b5d8bfaf2002ef7803500d12] Abstract Objective To investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in submandibular gland (SMG), periodontal bone and gingiva. Methods Bilateral EP was induced for two weeks in anesthetized male rats. The effect of systemic and local administration of H4R antagonists (JNJ7777120, JNJ10191584) on histopathology and functionality of SMG, ... περισσότερα »
‘Canalization’ of the frontal sinus: a functional approach for the management of post-traumatic sinusitis with lateral bony septa
. Report of two cases and long-term follow-up via Oral and Maxillofacial Surgery Publication date: Available online 26 February 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): J.-P. Foy, R.H. Khonsari, C. Bertolus, F. Espitalier, C. Ferron, P. Corre, A. Faure The patency of the naso-frontal duct is a key issue in the surgical management of chronic frontal sinusitis. Most of the current operative techniques only provide access to the paramedian portions of the frontal sinus. A canalization approach that allows a functional frontal sinus to be maintained ... περισσότερα »
Self-harm injuries in the maxillofacial region
Management of self-harm injuries in the maxillofacial region: a report of two cases and review of the literature via Oral and Maxillofacial Surgery Publication date: Available online 26 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Elizabeth Gonzalez Malaga, Eva Muñoz Aguilera, Carolyn Eaton, Phillip Ameerally Clinicians face numerous challenges when managing psychiatric patients who self-inflict injuries within the maxillofacial region. In addition to a complex clinical examination, there are both surgical and psychiatric factors to consider, such as the ... περισσότερα »
The Surgical Apgar Score to microvascular head and neck reconstruction
Application of via Oral and Maxillofacial Surgery Publication date: Available online 26 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Kyle S. Ettinger, Eric J. Moore, Christine M. Lohse, Matthew D. Reiland, Jacob G. Yetzer, Kevin Arce BackgroundThe Surgical Apgar Score (SAS) is a recently devised risk stratifying metric that relies on three intraoperative parameters to predict postoperative complications among surgical patients. The purpose of this study is to externally validate the SAS within a cohort of patients undergoing microvascular head and neck r... περισσότερα »
Immunohistochemical expression of secreted frizzled receptor protein 1 in the invasive front of tongue squamous cell carcinoma
Immunohistochemical expression of secreted frizzled receptor protein 1 in the invasive front of tongue squamous cell carcinoma: The Wnt signalling pathway is involved in the development of oral cancer. When inactivated, secreted frizzled receptor protein 1 (SFRP1), a cellular Wnt-inhibitor protein, may enhance cancer development. The aim of this study was to assess the expression of SFRP1 in the invasive front of tongue squamous cell carcinoma (SCC). Immunohistochemical expression of SFRP1 in the cohesive and discohesive invasive front of 36 resection specimens of tongue SCC was in...περισσότερα »
Silicone vs temporalis fascia interposition in TMJ ankylosis
: A comparison via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 28 February 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Sumit Gupta, Hemant Gupta, Shadab Mohammad, Hemant Mehra, Subodh Shankar Natu, Niharika Gupta ObjectiveTemporomandibular joint ankylosis (TMJa) is a distressing condition, but can be surgically managed by gap or interpositional arthroplasty, with an aim to restore joint function and prevent re-ankylosis. The aim of this paper is to compare two interposition materials use...περισσότερα »
Taste and speech following surgical tongue reduction
in children with Beckwith-Wiedemann syndrome via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 27 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Saskia M. Maas, Daniel J. Kadouch, Anne-Claire C.M. Masselink, Chantal M.A.M. Van Der Horst Beckwith-Wiedemann syndrome (BWS) is an overgrowth disorder in which macroglossia is one of the main signs. We investigated the long-term outcome of tongue surgery reduction (TRS) on taste and speech in patients with BWS who were more than 5 years of age and had undergone... περισσότερα »
Mandibular reconstruction with free fibula flap
Three-dimensional accuracy of virtual planning and surgical navigation for mandibular reconstruction with free fibula flap via Oral and Maxillofacial Surgery Publication date: Available online 27 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Yao Yu, Wen-Bo Zhang, Xiao-Jing Liu, Chuan-Bin Guo, Guang-Yan Yu, Xin Peng ObjectiveAlthough free fibula flaps are widely used for mandibular reconstruction, their three-dimensional position is difficult to control during conventional surgery. We aimed to improve this process by using computer-aided design (CAD) and su... περισσότερα »
Central Giant Cell Granuloma of the Mandible
Requiring Multiple Treatment Modalities – A Case Report via Oral and Maxillofacial Surgery Publication date: Available online 27 February 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): David Jerkins, Maximilian Malotky, Reza Miremadi, Mukund Dole Central giant cell granuloma (CGCG) is a relatively rare non-neoplastic, intraosseous lesion which exhibits a wide spectrum of clinical behavior and its management can be particularly challenging even for experienced clinicians. The etiopathogenesis of this disease process remains unclear, although factors such as trauma, i... περισσότερα »
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap
Repair of Posterior Glottic Stenosis with the Modified Endoscopic Postcricoid Advancement Flap: Posterior glottic stenosis is a difficult clinical problem that frequently results in bilateral vocal fold immobility, dyspnea, and tracheostomy dependence. Charts were reviewed of all patients undergoing a modified endoscopic postcricoid advancement flap procedure for posterior glottic stenosis between October 1, 2003, and June 30, 2015. Age, sex, operative findings, complications, and outcomes were noted. Follow-up was available in 10 of 11 patients, 10 of whom were successfully decann... περισσότερα »
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty
Evaluation of Heating and Shearing on the Viscoelastic Properties of Calcium Hydroxyapatite Used in Injection Laryngoplasty: Objective To compare the viscoelastic properties of calcium hydroxyapatite (CaHA) to carboxymethylcellulose (CMC) injectables used for injection laryngoplasty and determine if they are affected by heating and shearing. Study Design Experimental. Setting University laboratory. Subjects and Methods Vocal fold injection laryngoplasty with CaHA is oftentimes challenging due to the amount of pressure necessary to push the injectate through a needle. Anecdotal t... περισσότερα »
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients
AHI Outcomes Are Superior after Upper Airway Reconstructive Surgery in Adult CPAP Failure Patients: Objective This study aims to evaluate Apnea-Hypopnea Index (AHI) outcomes of upper airway adult obstructive sleep apnea (OSA) reconstructive surgery, as compared with outcomes of suboptimal continuous positive airway pressure (CPAP) therapy, in response to reviews claiming unreliable surgical AHI reduction. Study Design Prospective cohort study. Setting Single-surgeon series at medical centers within Wollongong, Australia. Subjects and Methods Adult patients with OSA who were part... περισσότερα »
Laryngeal Manifestations of Neurofibromatosis
Laryngeal Manifestations of Neurofibromatosis: Objectives To describe the range of findings in patients with neurofibromatosis (NF) presenting to a laryngology clinic and to analyze the etiologic factors of vocal fold dysfunction in this cohort. Study Design Case series with chart review. Setting Tertiary laryngology practice. Subjects and Methods All cases of NF presenting to an academic laryngology practice were retrospectively reviewed (August 2005 to May 2014), with a total of 34 cases. Demographic data, symptoms, and endoscopic examination findings were reviewed. Etiologic ... περισσότερα »
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation: Objective Adult abdominal fat, which is known to contain pluripotent stem cells, is frequently used to treat cerebrospinal fluid leak. The aim of this study was to assess the efficacy and reliability of abdominal fat graft to close large skull base defects after extirpation of malignant sinonasal tumors. Study Design Case series with chart review performed between 2009 and 2014. Subjects and Methods Twenty-nine cases were included of consecutive patients who were suffering ... περισσότερα »
Inpatient Pediatric Tonsillectomy: Does Hospital Type Affect Cost and Outcomes of Care?
Inpatient Pediatric Tonsillectomy: Does Hospital Type Affect Cost and Outcomes of Care?: Objective To ascertain whether hospital type is associated with differences in total cost and outcomes for inpatient tonsillectomy. Study Design Cross-sectional analysis of the 2006, 2009, and 2012 Kids’ Inpatient Database (KID). Subjects and Methods Children ≤18 years of age undergoing tonsillectomy with/without adenoidectomy were included. Risk-adjusted generalized linear models assessed for differences in hospital cost and length of stay (LOS) among children managed by (1) non–children’s t... περισσότερα »
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy: The objective was to determine the incidence of exposure of the lingual branch of the glossopharyngeal nerve during tonsillectomy with a retrospective review of surgical findings in 138 children who underwent total tonsillectomy at a tertiary medical center. Age, sex, surgical indication, tonsil size, congenital abnormalities, operative time, and surgical findings indicating the presence or absence of the glossopharyngeal nerve in the tonsillar fossa were recorded. Statistical analysis was perf... περισσότερα »
Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base
Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base: Objective With the emergence of transoral robotic approaches, head and neck surgeons are faced with an unfamiliar inside-out head and neck anatomy. This study was performed to describe key anatomic landmarks and surgical considerations of transoral robotic resection of the lateral oropharyngeal wall, the parapharyngeal space, and the base of the tongue. Study Design Descriptive transoral anatomic study. Setting Academic anatomy laboratory and tertiary academ...περισσότερα »
Postoperative Complications in Elderly Patients Undergoing Head and Neck Surgery: Opportunities for Quality Improvement
Postoperative Complications in Elderly Patients Undergoing Head and Neck Surgery: Opportunities for Quality Improvement: Objective To assess the frequency and nature of postoperative complications that occur in elderly patients, as compared with younger patients, following head and neck surgery. Study Design Cohort study of national database. Setting American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2013. Subjects and Methods We identified 29,891 patients who had head and neck surgery during the study period and classified them as having upp...περισσότερα »
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy
Occult Nodal Disease Prevalence and Distribution in Recurrent Laryngeal Cancer Requiring Salvage Laryngectomy: Objectives The indications for neck dissection concurrent with salvage laryngectomy in the clinically N0 setting remain unclear. Our goals were to determine the prevalence of occult nodal disease, analyze nodal disease distribution patterns, and identify predictors of occult nodal disease in a salvage laryngectomy cohort. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Patients with persistent or recurrent laryngeal squa...περισσότερα »
Lymph Node Yield as a Predictor of Survival in Pathologically Node Negative Oral Cavity Carcinoma
Lymph Node Yield as a Predictor of Survival in Pathologically Node Negative Oral Cavity Carcinoma: Objective Even after a pathologically node-negative (pN0) neck dissection for oral cavity squamous cell carcinoma (SCC), patients may develop regional recurrence. In this study, we (1) hypothesize that an increased number of lymph nodes removed (lymph node yield) in patients with pN0 oral SCC predicts improved survival and (2) explore predictors of survival in these patients using a multivariable model. Study Design Case series with chart review. Setting Administrative database anal... περισσότερα »
Readability and Understandability of Online Vocal Cord Paralysis Materials
Readability and Understandability of Online Vocal Cord Paralysis Materials: Objective Patients use several online resources to learn about vocal cord paralysis (VCP). The objective of this study was to assess the readability and understandability of online VCP patient education materials (PEMs), with readability assessments and the Patient Education Materials Evaluation Tool (PEMAT), respectively. The relationship between readability and understandability was then analyzed. Study Design and Setting Descriptive and correlational design. Method Online PEMs were identified by perfor... περισσότερα »
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty
Predicting Surgical Response Using Tensiometry in OSA Patients after Genioglossus Advancement with Uvulopalatopharyngoplasty: Objective To evaluate the role of tension on the genioglossus muscle in the performance of genioglossus advancement on sleep-disordered breathing in patients undergoing multilevel obstructive sleep apnea (OSA) surgery. Study Design Prospective study. Setting Academic practice. Subjects and Methods Twenty-three subjects underwent genioglossus advancement with uvulopalatopharyngoplasty for OSA. Subjects underwent pre- and postoperative polysomnography, ceph... περισσότερα »
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy
Cochlear Implantation in the Setting of Perioperative Anticoagulation and Antiplatelet Therapy: Objective To describe surgical outcomes and perioperative complications in patients taking antiplatelet and anticoagulation medications while undergoing cochlear implantation. Study Design Case series with chart review. Setting Two tertiary otologic referral center. Subjects and Methods Forty-six adult patients (2005-2014) who underwent cochlear implantation while on perioperative antiplatelet and/or anticoagulation therapy without interruption. Outcomes included estimated intraoperat... περισσότερα »
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer
Socioeconomic Factors Affect Outcomes in Well-Differentiated Thyroid Cancer: Objectives The effects of socioeconomic status (SES) on the incidence of well-differentiated thyroid cancer (WDTC) are well researched. However, the association between SES and outcomes is not delineated. Our objective was to determine if SES affected outcomes of WDTC. Study Designs Retrospective database review. Setting Tertiary care medical center. Subjects and Methods The Henry Ford Virtual Data Warehouse Tumor Registry was used to identify cases of WDTC. Socioeconomic data were obtained through the ...περισσότερα »
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy: Objective Evidence-based medicine is the gold standard practice model for patient management. Our aim was to determine whether decisions made by pediatric subspecialists regarding management of obstructive sleep apnea in children without tonsillar hypertrophy adhered to this model or were based on clinical experiences. Study Design Single-institution prospective study. Setting Multidisciplinary upper airway center in an academic pediatric hospital. Subjects and Methods Twelve pediatric subsp...περισσότερα »
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review: Objective Adenoid cystic carcinoma is a malignant minor salivary gland tumor that represents <1% of all laryngeal tumors. The submucosal location of laryngeal adenoid cystic carcinoma (LACC) results in delayed presentation. Here, we present the first systematic review of reported cases of LACC to determine trends in presentation, diagnostic and treatment modalities, and patient outcome. Data Sources PubMed, Web of Science, MEDLINE, and EMBASE databases. Methods A search of the above databases was done to identify articles re... περισσότερα »
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery: Objective Sphenopalatine artery ligation is a commonly employed surgical intervention for control of posterior epistaxis unresponsive to nasal packing. The objective of the present study was to evaluate the outcome of sphenopalatine artery ligation for control of epistaxis at our institution and the impact of timing and other factors on outcome. Study Design Case series with chart review. Setting Academic tertiary referral center. Subjects and Methods Case notes were review... περισσότερα »
Successful application of endoscopic modified medial maxillectomy to orbital floor trapdoor fracture
in a pediatric patient via Auris Nasus Larynx Publication date: Available online 27 February 2016 *Source:*Auris Nasus Larynx Author(s): Yasunori Matsuda, Hiroshi Sakaida, Masayoshi Kobayashi, Kazuhiko Takeuchi Although surgical treatment of orbital floor fractures can be performed by many different approaches, the application of endoscopic modified medial maxillectomy (EMMM) for this condition has rarely been described in the literature. We report on a case of a 7-year-old boy with a trapdoor orbital floor fracture successfully treated with the application of EMMM. The patient suffe...περισσότερα »
Benzalkonium chloride on histamine H1 receptor mRNA expression in nasal epithelial cells
Effects of by Masaki Kawabata, Junichiro Ohori, Yuichi Kurono via Auris Nasus Larynx To better understand the causes of the exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or benzalkonium chloride (BKC), we examined the impact of pretreatment with OMZ or BKC on cultured human nasal epithelial cells. We also examined the effect of mometasone furoate (MF) on the cultured human nasal epithelial cells treated with OMZ or BKC. AbstractObjective To better understand the causes of the exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or be... περισσότερα »
The Influence of Cognitive Factors on Outcomes with Frequency Lowering
IntroductionSince frequency lowering technology has become commercially available in modern digital hearing aids, researchers have set out to determine what benefits this technology could provide hearing-impaired patients. There is an abundance from #ENT via xlomafota13 on Inoreader http://ift.tt/1Sbuc7M via IFTTT
Understanding and Treating Severe and Profound Hearing Loss
Oticon has a history of creating excellent solutions for patients with severe-to-profound hearing loss. With the release of Oticon Dynamo, Sensei Super Power, and the Plus Power products in our performance line categories, we have again raised the ba from #ENT via xlomafota13 on Inoreader http://ift.tt/1XUleMt via IFTTT
Perioperative Ethical Issues
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Arvind Chandrakantan, Tracie Saunders Teaser Shared decision-making is a paradigm of patient engagement that is assuming greater importance in the era of value-based health care. The basic tenets include patient engagement on clinical decisions, taking into account multiple factors that influence physician and patient […]
Preoperative Laboratory Testing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Matthias Bock, Gerhard Fritsch, David L. Hepner Teaser Routine preoperative testing is not cost-effective, because it is unlikely to identify significant abnormalities. Abnormal findings from routine testing are more likely to be false positive, are costly to pursue, introduce a new risk, increase the […]
Preoperative Assessment of the Patient with Cardiac Disease Undergoing Noncardiac Surgery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Lee A. Fleisher Teaser The American College of Cardiology/American Heart Association has published Guidelines on Perioperative Evaluation. Preoperative evaluation should focus on identifying patients with symptomatic and asymptomatic coronary artery disease. The guidelines advocate using the American College of Surgeons National Surgical Quality Improvement […]
Preoperative Evaluation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Anand Lakshminarasimhachar, Gerald W. Smetana Teaser Postoperative pulmonary complications (PPCs) are common after major non-thoracic surgery and associated with significant morbidity and high cost of care. A number of risk factors are strong predictors of PPCs. The overall goal of the preoperative pulmonary evaluation […]
Stratification and Risk Reduction of Perioperative Acute Kidney Injury
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Selma Ishag, Charuhas V. Thakar Teaser Perioperative acute kidney injury (AKI) is associated with an increased morbidity and mortality. The incidence of AKI varies depending on preoperative risk factors and the surgical setting. Preoperative risk stratification is critical for informed consent and perioperative planning. […]
Perioperative Approach to Anticoagulants and Hematologic Disorders
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Jisu Kim, Richard Huh, Amir K. Jaffer Teaser Hematologic disorders and patients on anticoagulants or at risk for venous thromboembolism encompass a broad array of diagnoses, which can potentially complicate perioperative planning and management. This article addresses both bleeding and clotting concerns as well […]
Preoperative Anemia
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ankit J. Kansagra, Mihaela S. Stefan Teaser Previously undiagnosed anemia is often identified during routine assessment of surgical patients. Although studies suggest that perioperative anemia is associated with worse outcomes and a strong predictor for postoperative red cell transfusions, anemia is frequently ignored. Preoperative […]
Perioperative Approach to Anticoagulants and Hematologic Disorders
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Jisu Kim, Richard Huh, Amir K. Jaffer Teaser Hematologic disorders and patients on anticoagulants or at risk for venous thromboembolism encompass a broad array of diagnoses, which can potentially complicate perioperative planning and management. This article addresses both bleeding and clotting concerns as well as special hematologic issues. from Anaesthesia via ola Kala on Inoreader http://ift.tt/1oIlgL4 via IFTTT
Preoperative Anemia
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ankit J. Kansagra, Mihaela S. Stefan Teaser Previously undiagnosed anemia is often identified during routine assessment of surgical patients. Although studies suggest that perioperative anemia is associated with worse outcomes and a strong predictor for postoperative red cell transfusions, anemia is frequently ignored. Preoperative optimization of patients undergoing elective surgical procedures associated with significant blood loss, along with strategies to minimize intraoperative blood lo... περισσότερα »
Preoperative Nutrition and Prehabilitation
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ruchir Gupta, Tong J. Gan Teaser Enhanced recovery after surgery is the natural evolution of what were previously referred to as fast track programs and seeks to implement a series of interventions to improve and enhance recovery after major surgical procedures. Two important preoperative aspects are nutrition and prehabilitation. Identifying nutritionally deficient patients allows preoperative intervention to optimize their nutritional status. The contribution of cardiopulmonary exercise te... περισσότερα »
Preoperative Evaluation of Patients with Diabetes Mellitus
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Joshua D. Miller, Deborah C. Richman Teaser There are more than 29 million people in the United States with diabetes; it is estimated that by 2050, one in 3 individuals will have the disease. At least 50% of patients with diabetes are expected to undergo surgery in their lifetime. Complications from uncontrolled diabetes can impact multiple organ systems and affect perioperative risk. In this review, the authors discuss principles in diabetes management that will assist the perioperative cli... περισσότερα »
Preoperative Assessment of Geriatric Patients
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Justin G. Knittel, Troy S. Wildes Teaser Geriatric patients are over-represented in hospitalizations, surgeries, and perioperative complications. Special consideration is required for this patient group in the perioperative period because of the prevalence of comorbid diseases, functional impairments, and other deficits. A comprehensive preoperative evaluation strategy is recommended to identify and address these issues. Systematic, multidomain assessments should be performed and paired with... περισσότερα »
GSE66274 Integrative genomics analysis of genes with biallelic loss and its relation to the expression of mRNA and micro-RNA in esophageal squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Contributors* : Nan Hu ; Philip R Taylor ; Howard H Yang *Series Type* : Other *Organism* : Homo sapiens Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy number (CN) changes in tumors. In the current study we focus on biallelic loss and its relation to expression of mRNA and miRNA in ESCC using results from 500K SNP, mRNA, and miRNA arrays in 30 cases from a high-risk region of China. from squamous cell carcinoma via ok on Ino... περισσότερα »
GSE66274 Integrative genomics analysis of genes with biallelic loss and its relation to the expression of mRNA and micro-RNA in esophageal squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Contributors* : Nan Hu ; Philip R Taylor ; Howard H Yang *Series Type* : Other *Organism* : Homo sapiens Genomic instability plays an important role in human cancers. We previously characterized genomic instability in esophageal squamous cell carcinomas (ESCC) in terms of loss of heterozygosity (LOH) and copy number (CN) changes in tumors. In the current study we focus on biallelic loss and its relation to expression of mRNA and miRNA in ESCC using results from 500K SNP, mRNA, and miRNA arrays in 30 cases from a high-risk region of China. from squamous cell carcinoma via ok on Ino... περισσότερα »
Preoperative Clinics
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Angela F. Edwards, Barbara Slawski Teaser Preoperative evaluation clinics have been shown to enhance operating room efficiency, decrease day-of-surgery cancellations, reduce hospital costs, and improve the quality of patient care. Although programs differ in staffing, structure, financial support, and daily operations, they share the… Continue reading Preoperative Clinics
Preoperative Laboratory Testing
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Matthias Bock, Gerhard Fritsch, David L. Hepner Teaser Routine preoperative testing is not cost-effective, because it is unlikely to identify significant abnormalities. Abnormal findings from routine testing are more likely to be false positive, are costly to pursue, introduce a new risk, increase the… Continue reading Preoperative Laboratory Testing
Spatiotemporal Reconstruction of the Introduction of Hepatitis C Virus into Scotland and Its Subsequent Regional Transmission
Journal of Virology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OH17dv via IFTTT
Preoperative Consultations
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Stephan R. Thilen, Duminda N. Wijeysundera, Miriam M. Treggiari Teaser Preoperative consultation is an important intervention that likely has most benefits for intermediate-risk to high-risk patients undergoing major surgery. Consultation rates are likely increasing and there is significant practice variation in the use of… Continue reading Preoperative Consultations
Preoperative Evaluation
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Anand Lakshminarasimhachar, Gerald W. Smetana Teaser Postoperative pulmonary complications (PPCs) are common after major non-thoracic surgery and associated with significant morbidity and high cost of care. A number of risk factors are strong predictors of PPCs. The overall goal of the preoperative pulmonary evaluation… Continue reading Preoperative Evaluation
Sensory initiation of a co‐ordinated motor response: synaptic excitation underlying simple decision‐making
The Journal of Physiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pjJNGY via IFTTT
Perioperative Ethical Issues
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Arvind Chandrakantan, Tracie Saunders Teaser Shared decision-making is a paradigm of patient engagement that is assuming greater importance in the era of value-based health care. The basic tenets include patient engagement on clinical decisions, taking into account multiple factors that influence physician and patient… Continue reading Perioperative Ethical Issues
Meckel’s diverticulum complicated with gastro-intestinal stromal tumor: Case report
Publication date: Available online 27 February 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Islam H. Metwally, Amr F. Elalfy, Shadi Awny, Nirmeen Megahed IntroductionMeckel’s diverticulum is a common congenital anomaly, mostly asymptomatic. Tumors may arise rarely in these diverticulae. We claim presenting a new problem to the medical staff in Egypt.Case presentationWe report… Continue reading Meckel’s diverticulum complicated with gastro-intestinal stromal tumor: Case report
Sleep apnea
Sleep apnea: The temporary stoppage of breathing during sleep, often resulting in daytime sleepiness. Apnea is a Greek word that means «want of breath.» The most common form of sleep apnea is obstructive sleep apnea. In obstructive sleep apnea, the muscles of the soft palate around the base of the tongue and the uvula relax,… Continue reading Sleep apnea
Tumeurs malignes des gaines nerveuses périphériques intracérébrales métastatiques : à propos de deux cas et revue exhaustive des cas de la littérature
Publication date: Available online 27 February 2016 Source:Cancer/Radiothérapie Author(s): C. Le Fèvre, J. Castelli, C. Perrin, P.L. Hénaux, G. Noël Les tumeurs malignes des gaines nerveuses périphériques sont des tumeurs rares qui peuvent être associées à une neurofibromatose de type 1, ayant un pronostic défavorable, dont le traitement repose sur la chirurgie. La radiothérapie et… Continue reading Tumeurs malignes des gaines nerveuses périphériques intracérébrales métastatiques : à propos de deux cas et revue exhaustive des cas de la littérature
Thickness dependence of light transmittance, translucency and opalescence of a ceria-stabilized zirconia/alumina nanocomposite for dental applications
Publication date: Available online 28 February 2016 *Source:*Dental Materials Author(s): Takanobu Shiraishi, Ikuya Watanabe ObjectivesThis study was conducted to investigate thickness dependence of light transmittance, translucency and opalescence of a commercially available fully-sintered ceria-stabilized zirconia/alumina nanocomposite for dental all-ceramic restorations.MethodsThree disk samples of 16mm in diameter and thickness ranging from 0.2 to 0.6mm with 0.1mm increment each were cut from a fully-sintered rod-shaped Ce-TZP/alumina nanocomposite (NANOZR, Panasonic Healthcare, ... περισσότερα »
Fracture strength, failure type and Weibull characteristics of lithium disilicate and multiphase resin composite endocrowns under axial and lateral forces
Publication date: Available online 28 February 2016 *Source:*Dental Materials Author(s): Marco M.M. Gresnigt, Mutlu Özcan, Mieke L.A. van den Houten, Laura Schipper, Marco S. Cune ObjectiveMultiphase resin composite materials have been advocated as an alternative to reinforced ceramics but limited information is available to date on their stability. This in vitro study evaluated the effect of axial and lateral forces on the strength of endocrowns made of Li2Si2O5 and multiphase resin composite.MethodsSound human molars (N=60, n=10 per group) were randomly divided into 6 groups: Grou...περισσότερα »
Anticipatory extended cholecystectomy: the ‘Lucknow’ approach for thick walled gall bladder with low suspicion of cancer
Background: Gall stones (GS) cause inflammation of the gall bladder (GB) i.e., chronic cholecystitis (CC) and xantho-granulomatous cholecystitis (XGC) which can result in a thick walled GB (TWGB). Gall bladder cancer (GBC) may also present as TWGB. While CC and XGC can be treated with simple cholecystectomy (SC), GBC merits extended cholecystectomy (EC). We propose… Continue reading Anticipatory extended cholecystectomy: the ‘Lucknow’ approach for thick walled gall bladder with low suspicion of cancer
Preoperative Evaluation of Patients with Diabetes Mellitus
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Joshua D. Miller, Deborah C. Richman Teaser There are more than 29 million people in the United States with diabetes; it is estimated that by 2050, one in 3 individuals will have the disease. At least 50% of patients with diabetes are expected to… Continue reading Preoperative Evaluation of Patients with Diabetes Mellitus
Preoperative Evaluation of Patients with Diabetes Mellitus
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Joshua D. Miller, Deborah C. Richman Teaser There are more than 29 million people in the United States with diabetes; it is estimated that by 2050, one in 3 individuals will have the disease. At least 50% of patients with diabetes are expected to… Continue reading Preoperative Evaluation of Patients with Diabetes Mellitus
CROSS and beyond: a clinical perspective on the results of the randomized ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study
Despite extensive research efforts oesophageal cancer remains a malignancy with a poor prognosis. Improvement of treatment is urgently needed. Although multimodality treatment for resectable oesophageal cancer has established it place in standard practice, there are still many differences worldwide in the preferred treatment. The Dutch ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study (CROSS) trial… Continue reading CROSS and beyond: a clinical perspective on the results of the randomized ChemoRadiotherapy for Oesophageal cancer followed by Surgery Study
Preoperative Assessment of Geriatric Patients
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Justin G. Knittel, Troy S. Wildes Teaser Geriatric patients are over-represented in hospitalizations, surgeries, and perioperative complications. Special consideration is required for this patient group in the perioperative period because of the prevalence of comorbid diseases, functional impairments, and other deficits. A comprehensive preoperative… Continue reading Preoperative Assessment of Geriatric Patients
Preoperative Assessment of Geriatric Patients
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Justin G. Knittel, Troy S. Wildes Teaser Geriatric patients are over-represented in hospitalizations, surgeries, and perioperative complications. Special consideration is required for this patient group in the perioperative period because of the prevalence of comorbid diseases, functional impairments, and other deficits. A comprehensive preoperative… Continue reading Preoperative Assessment of Geriatric Patients
Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab
Background: Monoclonal antibodies are an invaluable therapeutic class when it comes to cancer therapy. One of the primary mechanisms of anti-tumor activity of monoclonal antibodies is antibody dependent cell-mediated cytotoxicity (ADCC) mediated by natural killer (NK) cells. Innate immune effector cells play important roles in generating and maintaining antitumor immunity to enhance ADCC. Methods: Efficacy… Continue reading Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab
Implantable Devices
Publication date: March 2016 Source:Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ana Costa, Deborah C. Richman Teaser Technology is the prominent feature of the twenty-first century, including in medicine. There are very few organs that cannot be stimulated, shocked, or infused. With more and more implantable devices being approved for clinical use, anesthesiologists have to… Continue reading Implantable Devices
The supportive care needs for prostate cancer patients in Sarawak
Background: This cross-sectional study aimed to determine the prevalence of unmet supportive care needs among prostate cancer patients. Methods: The cross-sectional study was conducted among all prostate cancer patients at the Sarawak General Hospital. Interview was done using the Supportive Care Needs Survey-Short Form (SCNS-SF) and the Health Service Utilization Questionnaires (HSUQ). Data were analysed… Continue reading The supportive care needs for prostate cancer patients in Sarawak
MRT-Methoden zur Ventilations- und Perfusionsbildgebung der Lunge
Fokus auf regionale Bilder Die Hauptwerkzeuge zur Bestimmung der Lungenfunktion wie Spirometrie & Ganzkörperplethysmographie ermöglichen oft nur globale Aussagen. Dadurch motiviert wurden MRT-Methoden entwickelt, die regional unterschiedliche Beeinträchtigungen der Lunge sichtbar machen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QFMXut via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs… Continue reading MRT-Methoden zur Ventilations- und Perfusionsbil... περισσότερα »
Preoperative Nutrition and Prehabilitation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ruchir Gupta, Tong J. Gan Teaser Enhanced recovery after surgery is the natural evolution of what were previously referred to as fast track programs and seeks to implement a series of interventions to improve and enhance recovery after major surgical procedures. Two important preoperative aspects are nutrition and prehabilitation. Identifying nutritionally deficient patients allows preoperative intervention to optimize their nutritional status. The contribution of cardiopulmonary exercise te... περισσότερα »
Preoperative Evaluation of Patients with Diabetes Mellitus
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Joshua D. Miller, Deborah C. Richman Teaser There are more than 29 million people in the United States with diabetes; it is estimated that by 2050, one in 3 individuals will have the disease. At least 50% of patients with diabetes are expected to undergo surgery in their lifetime. Complications from uncontrolled diabetes can impact multiple organ systems and affect perioperative risk. In this review, the authors discuss principles in diabetes management that will assist the perioperative cli... περισσότερα »
Preoperative Assessment of Geriatric Patients
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Justin G. Knittel, Troy S. Wildes Teaser Geriatric patients are over-represented in hospitalizations, surgeries, and perioperative complications. Special consideration is required for this patient group in the perioperative period because of the prevalence of comorbid diseases, functional impairments, and other deficits. A comprehensive preoperative evaluation strategy is recommended to identify and address these issues. Systematic, multidomain assessments should be performed and paired with... περισσότερα »
Implantable Devices
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Publication date: March 2016 *Source:*Anesthesiology Clinics, Volume 34, Issue 1 Author(s): Ana Costa, Deborah C. Richman Teaser Technology is the prominent feature of the twenty-first century, including in medicine. There are very few organs that cannot be stimulated, shocked, or infused. With more and more implantable devices being approved for clinical use, anesthesiologists have to regularly take care of patients who have these devices. An understanding of the devices, the associated comorbidities, and the perioperative risks is crucial for safe management of these patients. Ca... περισσότερα »
MRT-Methoden zur Ventilations- und Perfusionsbildgebung der Lunge
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Fokus auf regionale Bilder Die Hauptwerkzeuge zur Bestimmung der Lungenfunktion wie Spirometrie & Ganzkörperplethysmographie ermöglichen oft nur globale Aussagen. Dadurch motiviert wurden MRT-Methoden entwickelt, die regional unterschiedliche Beeinträchtigungen der Lunge sichtbar machen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QFMXut via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Clinical outcomes and toxicity of postoperative intensity-modulated versus three-dimensional conformal radiation therapy in patients with cervical cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Abstract Aim To compare the clinical outcomes and toxicity of pelvic intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3D-CRT) as adjuvant postoperative treatment in patients with cervical cancer. Methods Between April 2008 and December 2013, 115 patients with International Federation of Gynecology and Obstetrics stages IA–IIB cervical cancer were initially treated with radical […]
Impact of a brief exercise program on the physical and psychosocial health of prostate cancer survivors: A pilot study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
ABSTRACT Aim It is well established that exercise is beneficial for prostate cancer survivors. The challenge for health professionals is to create effective strategies to encourage survivors to exercise in the community. Many community exercise programs are brief in duration (e.g. <5 exercise sessions); whilst evidence for the efficacy of exercise within the literature are […]
Towards an intelligent network for matching offer and demand: From the sharing economy to the global brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Publication date: Available online 28 February 2016 Source:Technological Forecasting and Social Change Author(s): Francis Heylighen We analyze the role of the Global Brain in the sharing economy, by synthesizing the notion of distributed intelligence with Goertzel’s concept of an offer network. An offer network is an architecture for a future economic system based on the […]
Multiple myeloma: Updates for pharmacists in the treatment of relapsed and refractory disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
There have been a number of recent advances in the treatment of patients with relapsed and refractory multiple myeloma. However, despite additional FDA-approved therapies including carfilzomib and pomalidomide as well as clinical trials investigating new combinations of existing treatments, multiple myeloma remains an incurable disease. New therapies currently in the drug development pipeline for relapsed […]
Capecitabine-induced ventricular fibrillation arrest: Possible Kounis syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
We report the case of capecitabine-induced ventricular fibrillation arrest, possibly secondary to type I Kounis syndrome. A 47-year-old man with a history of T3N1 moderately differentiated adenocarcinoma of the colon, status-post sigmoid resection, was started on adjuvant capecitabine approximately five months prior to presentation of cardiac arrest secondary to ventricular fibrillation. An electrocardiogram (EKG) revealed […]
Abraxane(R) versus Taxol(R) for patients with advanced breast cancer: A prospective time and motion analysis from a Chinese health care perspective
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Background Abraxane® and Taxol® are both effective drugs for the treatment of advanced stage breast cancer. However, each agent possesses unique drug delivery characteristics with the former not requiring premedication and having a considerably shorter recommended infusion time (i.e. 30 min vs. 2–4 h). To measure the overall efficiency and cost-saving potential associated with Abraxane® […]
Can fentanyl transdermal patches prevent the cutaneous hyperpigmentation related to radiotherapy in patients with cancer?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Dermatologic adverse effects related to radiotherapy are one of the most important cosmetic problems and affect the quality of life in patients with cancer. In a male patient with non-small cell lung cancer who received palliative radiotherapy, the hyperpigmentation related to radiotherapy was examined two months later except for fentanyl transdermal patch area. The inhibitory […]
Assessing outcomes of adult oncology patients treated with linezolid versus daptomycin for bacteremia due to vancomycin-resistant Enterococcus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Background The incidence and severity of vancomycin-resistant Enterococcus blood stream infections continue to rise and is a significant burden in the healthcare setting. Literature thus far is minimal regarding treatment outcomes in patients with malignancy and vancomycin-resistant Enterococcus bacteremia. Appropriate antibiotic selection is vital to treatment success due to high rates of resistance, limited antimicrobials […]
Successful use of palifermin following severe anaphylaxis to pegaspargase in a pediatric patient with acute lymphoblastic leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 ώρες
Palifermin and pegaspargase are Escherichia coli-derived drug products. Hypersensitivity reactions, including anaphylaxis, are frequently reported with pegaspargase. In high-risk acute lymphoblasic leukemia (ALL), patients undergoing allogeneic hematopoietic stem cell transplant may be treated with palifermin as a supportive care measure for mucositis prophylaxis. However, no literature exists documenting the cross-reactivity between palifermin and pegaspargase. We […]
Validation of neural spike sorting algorithms without ground-truth information
[image: S01650270.gif] Publication date: Available online 28 February 2016 *Source:*Journal of Neuroscience Methods Author(s): Alex H. Barnett, Jeremy F. Magland, Leslie F. Greengard BackgroundThe throughput of electrophysiological recording is growing rapidly, allowing thousands of simultaneous channels, and there is a growing variety of spike sorting algorithms designed to extract neural firing events from such data. This creates an urgent need for standardized, automatic evaluation of the quality of neural units output by such algorithms.New MethodWe introduce a suite of validatio...περισσότερα »
Source modeling of ElectroCorticoGraphy (ECoG) data: Stability analysis and spatial filtering
[image: S01650270.gif] Publication date: 1 April 2016 *Source:*Journal of Neuroscience Methods, Volume 263 Author(s): A. Pascarella, C. Todaro, M. Clerc, T. Serre, M. Piana BackgroundElectrocorticography (ECoG) measures the distribution of the electrical potentials on the cortex produced by the neural currents. A full interpretation of ECoG data requires solving the ill-posed inverse problem of reconstructing the spatio-temporal distribution of the neural currents. This study addresses the ECoG source modeling developing a beamformer method.New methodWe computed the lead-field matrix... περισσότερα »
Giant primary hydatid cyst of retroperitoneum
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1Sba2uC via IFTTT
Bicycle helmet use to reduce the impact of head injuries in ladder users
Background The aim of this study was to determine if wearing a bicycle helmet during ladder use could reduce the incidence and severity of head injury in the event of a fall. Methods A headform model with inbuilt accelerometers was used to determine the Head Injury Criterion (HIC) score of head impact by dropping 41 helmeted and unhelmeted headforms from eight heights. These results were compared. Results There was a statistically significant difference between averaged HIC scores in helmeted and unhelmeted drops (*P* < 0.001). Unhelmeted HIC scores ranged from 387 at 0.25 m to...περισσότερα »
Small bowel obstruction and perforation following ingestion of an oyster shell
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Sequential magnetic resonance imaging changes in neurocysticercosis
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1RdWoC1 via IFTTT
Impact of a clinical decision making module on the attitudes and perceptions of surgical trainees
Background Decision making, a cognitive non-technical skill, is a key element for clinical practice in surgery. Specific teaching about methods in clinical decision making (CDM) is a very recent addition to surgical training curricula in the UK and Ireland. Baseline trainee opinion on decision-making modules is unknown. The Royal College of Surgeons in Ireland's postgraduate training boot camp inaugural CDM module was investigated to elucidate the impact on the attitudes of CDM naïf trainees. Methods Three standardized two-hour workshops for three trainee groups were delivered. ... περισσότερα »
Real time cerebral perfusion monitoring in acute trauma patients: a preliminary study
Background Management of traumatic brain injury is focused on preventing secondary damage. Early recognition of brain ischaemia may improve the final outcome of the trauma victim. The primary aim of this study was to examine the correlation between peripheral oxygen pulse oximetry and brain oxygen saturation measured by a near infrared oximetry device. A second aim was to evaluate the influence of different factors such as fluid and blood administration on brain tissue oxygenation. Methods This was a prospective pilot study. Mechanically ventilated trauma patients admitted to th...περισσότερα »
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