Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
[image: http:--http://ift.tt/1pviIAx] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.* Nat Genet. 2015 Nov;47(11):1282-93 Authors: Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, Drong AW, Abbott J, Wahl S, Tan ST, Scott WR, Campanella G, Chadeau-Hyam M, Afzal U, Ahluwalia TS, Bonder MJ, Chen P, Dehghan A, Edwards TL, Esko T, Go MJ, Harris SE, Hartiala J, Kasela S, Kasturiratne A,... περισσότερα »
Health-Related Quality of Life in Patients with MPS II.
[image: http:--production.springer.de-OnlineReso] Related Articles *Health-Related Quality of Life in Patients with MPS II.* J Genet Couns. 2015 Aug;24(4):635-44 Authors: Needham M, Packman W, Quinn N, Rappoport M, Aoki C, Bostrom A, Cordova M, Macias S, Morgan C, Packman S Abstract Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are base... περισσότερα »
Synthesis and biological evaluation of quinoline derivatives as potential anti-prostate cancer agents and Pim-1 kinase inhibitors
Publication date: Available online 7 March 2016 *Source:*Bioorganic & Medicinal Chemistry Author(s): Kun Li, Ying Li, Di Zhou, Yinbo Fan, Hongye Guo, Tianyi Ma, Jiachen Wen, Dan Liu, Linxiang Zhao In this work, a series of quinoline derivatives were designed and synthesized as antitumor agents. Most quinolines showed potent anti-proliferative activity against human prostatic cancer PC-3 cell line. Among which, 9d, 9f and 9g were the most effective compounds with GI50 values of 2.60, 2.81 and 1.29 μM, respectively. Structure-activity relationship analysis indicated that the secondary...περισσότερα »
Design and Evaluation of Novel Glutaminase Inhibitors
Publication date: Available online 7 March 2016 *Source:*Bioorganic & Medicinal Chemistry Author(s): Lee A. McDermott, Prema Iyer, Larry Vernetti, Shawn Rimer, Jingran Sun, Melissa Boby, Tianyi Yang, Michael Fioravanti, Jason O'Neil, Liwei Wang, William Katt, Qingqiu Huang, Richard Cerione A novel set of GAC (Kidney Glutaminase Isoform C) inhibitors able to inhibit the enzymatic activity of GAC and the growth of the triple negative MDA-MB-231 breast cancer cells with low nanomolar potency is described. Compounds in this series have a reduced number of rotatable bonds, improved ClogP... περισσότερα »
Discovery of Novel Pyrrole-Based Scaffold as Potent and Orally Bioavailable Free Fatty Acid Receptor 1 Agonists for the Treatment of Type 2 Diabetes
Publication date: Available online 7 March 2016 *Source:*Bioorganic & Medicinal Chemistry Author(s): Zheng Li, Miaobo Pan, Xin Su, Yuxuan Dai, Mian Fu, Xingguang Cai, Wei Shi, Wenlong Huang, Hai Qian The free fatty acid receptor 1 (FFA1) has gained significant interest as a novel antidiabetic target. Most of FFA1 agonists reported in the literature bearing a common biphenyl scaffold, which was crucial for toxicity verified by the researchers of Daiichi Sankyo. Herein, we describe the systematic exploration of non-biphenyl scaffold and further chemical modification of the optimal pyr...περισσότερα »
Aesthetic and Functional Rhinoplasty: The RHINO Scale
A Comprehensive Quality-of-Life Instrument for Aesthetic and Functional Rhinoplasty: The RHINO Scale: Background: Currently, there is no validated quality-of-life instrument that evaluates both functional and aesthetic outcomes after rhinoplasty. The goal of this study was to develop and validate a comprehensive quality-of-life instrument to assess patient satisfaction with both functional and aesthetic outcomes after rhinoplasty. Methods: The study was designed as a prospective instrument validation study at a university-affiliated academic medical center. Inclusion criteria incl...περισσότερα »
Opioid-Induced Androgen Deficiency
Effects of Testosterone Replacement on Metabolic and Inflammatory Markers in Men with Opioid-Induced Androgen Deficiency: Abstract Objective Symptomatic androgen deficiency is common in patients taking opioid analgesics, and testosterone replacement in these men improves libido, quality of life and body composition. However, the effects of testosterone replacement on metabolic and inflammatory markers in this setting have not been evaluated. This is important as opiate use itself has been associated with metabolic abnormalities. The objective of this investigation was to determine ... περισσότερα »
Liothyronine compared to l-thyroxine.For patients taking long-term liothyronine we did not identify any additional risk of atrial fibrillation, cardiovascular disease or fractures. There was an increased incident use of antipsychotic medication during follow up.
Liothyronine use in a 17 year observational population-based study - The tears study: Abstract Objective To look at adverse outcomes for patients on liothyronine compared to l-thyroxine. Some trials have examined the relative merits of liothyronine but none have looked at adverse outcomes in large numbers Study Design An observational study of all patients prescribed thyroid hormone replacement in Tayside Scotland (population 400,000) from 1997 to 2014. Patients A study group of patients having ever used liothyronine (n=400) was compared to those who had only used l-thyroxine (n=33,9... περισσότερα »
In patients with PTC of low or intermediate risk an excellent response to initial therapy can be defined based on nonstimulated Tg ≤ 0.2 ng/ml
Can the follow-up of patients with papillary thyroid carcinoma of low and intermediate risk and excellent response to initial therapy be simplified using second-generation thyroglobulin assays?: Summary Objective In view of the low probability of recurrence, the cost-effective follow-up of patients with papillary thyroid carcinoma (PTC) of low or intermediate risk and excellent response to initial therapy represents a challenge. This study evaluated the cases of structural recurrence among these patients. Patients The sample comprised 578 patients with PTC of low or intermediate risk... περισσότερα »
Normocalcaemic hyperparathyroidism
Clinical Question: Elevated PTH with normal serum calcium level: a structured approach: Summary Normocalcaemic hyperparathyroidism is a common biochemical finding, usually identified during an assessment of bone or renal health. Hypercalcaemia must be considered by calculation of adjusted calcium, and a careful history taken to assess dietary calcium intake and for the possibility of a malabsorption syndrome. 25OHD should be measured and replaced if indicated. The management plan for the patient is influenced by the context in which calcium and PTH were measured. In this brief revi... περισσότερα »
How our authors are using Kudos
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Have you heard of Kudos? It’s a platform which helps researchers to explain and share their work with a wider audience. Sounds pretty good, but what do scientists who are actually using it think about it? We asked Dr Jesse Harrison for his thoughts. His paper looking at life within extreme environments was published last […]
General Framework for Meta-Analysis of Haplotype Association Tests
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
ABSTRACT For complex traits, most associated single nucleotide variants (SNV) discovered to date have a small effect, and detection of association is only possible with large sample sizes. Because of patient confidentiality concerns, it is often not possible to pool genetic data from multiple cohorts, and meta-analysis has emerged as the method of choice to […]
Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Cell autonomous and nonautonomous requirements for Delltalike1 during early mouse retinal neurogenesis. Dev Dyn. 2016 Mar 7; Authors: Riesenberg AN, Brown NL Abstract BACKGROUND: In the vertebrate retina six neuronal and one glial cell class are produced from a common progenitor pool. During neurogenesis, adjacent retinal cells use Notch signaling to maintain a pool of […]
Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Microglia are the resident macrophage population of the central nervous system (CNS) and play essential roles, particularly in inflammation-mediated pathological conditions such as ischemic stroke. Increasing … from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pcUriY via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Cancer heterogeneity and drug metabolism: what we know and what we need to know
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 3 δευτερόλεπτα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LOidvv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Parathyroid Carcinoma : Preoperative diagnosis and prognosis
Preoperative diagnosis and prognosis in 40 Parathyroid Carcinoma Patients: Summary Objective Parathyroid carcinoma (PC) is a rare disease which is difficult to diagnose preoperatively and predict prognosis. The goal of this study was to analyse the preoperative predictive factors and prognostic factors in PC patients and to evaluate the possibility of diagnosing PC preoperatively. Design, Setting and Patients This is a retrospective study from Jan 2000 to Aug 2015 conducted in Shanghai Ruijin Hospital. Measurements Comparisons were made between 40 parathyroid carcinoma patients and 28...περισσότερα »
Individual tumor volume responses to short-course oxaliplatin-containing induction chemotherapy in locally advanced rectal cancer – Targeting the tumor for radiation sensitivity?
Publication date: Available online 8 March 2016 *Source:*Radiotherapy and Oncology Author(s): Kjersti Flatmark, Marie G. Saelen, Knut H. Hole, Torveig W. Abrahamsen, Karianne G. Fleten, Helga H. Hektoen, Kathrine R. Redalen, Therese Seierstad, Svein Dueland, Anne H. Ree BackgroundNeoadjuvant treatment of locally advanced rectal cancer (LARC) involves chemoradiotherapy (CRT), which may cause significant toxicity, and the potential role and sequential placement of neoadjuvant chemotherapy (NACT) relative to CRT is under debate.Patients and methodsIn a non-randomized study of 72 LARC pat... περισσότερα »
Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma
An Unusual Solitary Thyroid Nodule with Bloody Follicles: Metastatic Renal Cell Carcinoma Within an Infiltrative Follicular Variant Papillary Carcinoma:
TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas
Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas: AbstractThis study is aimed to investigate the *BRAF* *V600E* and *TERT* promoter mutation profile of 50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates. The median age at the time of surgery was 16 years (range, 6–18). No *TERT* promoter mutations were identified in this series. The *BRAF* *V600E* mutation was present in 15 (30 %) tumors. From genotype-his... περισσότερα »
Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency
Inadequate iodine nutrition of pregnant women in an area of iodine sufficiency: Abstract PurposeI. R. Iran has been considered iodine replete since 2000, but iodine nutrition of vulnerable subjects is not clear. The main goal of this study was assessment of iodine nutrition and thyroid function in pregnant Iranian women. MethodsA total of 1072 pregnant women from ten provinces in the different parts of the country were recruited from November to March 2014. Median urinary iodine concentration (UIC) as the measure of iodine status and serum free T4 (FT4), thyrotropin (TSH), thy... περισσότερα »
Pituitary Stalk lesions
Pituitary Stalk lesions: systematic review and clinical guidance: Summary The spectrum of pituitary stalk (PS) pathology is vast, presenting a diagnostic challenge. Published large series of PS lesions demonstrate neoplastic conditions are most frequent, followed by inflammatory, infectious and congenital diseases. Inflammatory pathologies however, account for the majority of PS lesions in published small case series and case reports. Physicians must be familiar with the major differential diagnoses and necessary investigations. A comprehensive history and thorough clinical examina... περισσότερα »
Stress-triggered Graves’ disease
Certain HLA alleles are associated with stress-triggered Graves’ disease and influence its course: AbstractThere are no studies on HLA analysis in patients in whom Graves’ disease (GD) hyperthyroidism has been preceded by ≥1 stressful event. The aim of the present study was to identify predisposing or protecting HLA alleles and their effects on the course of GD in this subset of patients. We performed serological HLA typing in 58 Caucasian patients with stress-related GD and in 130 matched healthy controls (HC). We also performed genomic HLA typing in 20/58 patients and in all HC. ... περισσότερα »
Skin whitening agents
Overview of skin whitening agents with an insight into the illegal cosmetic market in Europe: [image: cover.gif?v=1&s=9ed7c8a5ea459f238bf70b29] Abstract Lightening skin tone is an ancient and well-documented practice, and remains common practice among many cultures. Whitening agents such as corticosteroids, tretinoin and hydroquinone are medically applied to effectively lighten the skin tone of hyperpigmented lesions. However, when these agents are used cosmetically, they are associated with a variety of side-effect. Alternative agents, such as arbutin and its derivatives kojic ... περισσότερα »
An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011.
*An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011.* Allergy. 2016 Mar 7; Authors: Wang X, Zheng M, Lou H, Wang C, Zhang Y, Bo M, Ge S, Zhang N, Zhang L, Bachert C Abstract BACKGROUND: The prevalence of allergic rhinitis (AR) has increased worldwide in recent decades. The present study was conducted to investigate the prevalence of self-reported AR and profiles of AR-related comorbidities in the adult population of China over time. METHODS: This study surveyed residents of 18 major cities in mainland China. Telephone interviews w...περισσότερα »
A human trigeminovascular biomarker for antimigraine drugs
A human trigeminovascular biomarker for antimigraine drugs: A randomised, double-blind, placebo-controlled, crossover trial with sumatriptan: Current antimigraine drugs are believed, besides their direct vasoconstrictive effect, to inhibit calcitonin gene-related peptide (CGRP) release from trigeminal nerve endings during migraine. Objective The objective of this report is to establish a biomarker for the CGRP-interfering effect of antimigraine drugs. Methods We quantified the effect of sumatriptan on the trigeminal nerve-mediated rise in forehead dermal blood flow (DBF), induced... περισσότερα »
Coexisting vascular lesions in reversible cerebral vasoconstriction syndrome
Coexisting vascular lesions in reversible cerebral vasoconstriction syndrome: Background The pathophysiology of reversible cerebral vasoconstriction syndrome (RCVS) is not known. Published cases have documented coexisting cervical artery dissection and unruptured aneurysms, raising the possibility that ultrastructural vessel wall abnormalities underlie the development of vascular lesions as well as RCVS. Methods In this retrospective study we compared the frequency of neurovascular abnormalities in 158 consecutive RCVS patients, 44 patients with primary angiitis of the central ner...περισσότερα »
Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?
*Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?* Med Dosim. 2016 Mar 2; Authors: Yu Y, Chen J, Leary CI, Shugard E, Yom SS Abstract Radiation of the low neck can be accomplished using split-field intensity-modulated radiation therapy (sf-IMRT) or extended-field intensity-modulated radiation therapy (ef-IMRT). We evaluated the effect of these treatment choices on target coverage and thyroid and larynx doses. Using data from 14 patients with cancers of the oropharynx, we compared... περισσότερα »
[Head and neck localizations of hydatid cyst: A series of 17 cases].
*[Head and neck localizations of hydatid cyst: A series of 17 cases].* Rev Stomatol Chir Maxillofac Chir Orale. 2016 Mar 3; Authors: El Bousaadani A, Abada R, Rouadi S, Roubal M, Mahtar M, Kadiri F Abstract INTRODUCTION: Head and neck localizations of hydatid cyst are very rare (1% of human cases) even in countries where echinococcosis is endemic (human sites). Our objective was to report the epidemiological, and clinical characteristics and the management of head and neck localizations of hydatid cyst. MATERIALS AND METHODS: A retrospective descriptive study of 17 cases of head a...περισσότερα »
Health-Related Quality of Life in Patients with MPS II.
[image: http:--production.springer.de-OnlineReso] Related Articles *Health-Related Quality of Life in Patients with MPS II.* J Genet Couns. 2015 Aug;24(4):635-44 Authors: Needham M, Packman W, Quinn N, Rappoport M, Aoki C, Bostrom A, Cordova M, Macias S, Morgan C, Packman S Abstract Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a chronic and progressive X-linked lysosomal disease that mainly affects males. The National MPS Society (2013) reports that MPS II affects 1 in 100,000 to 1 in 150,000 males worldwide. Two distinct forms of the disease are base... περισσότερα »
Errors, Confusion Common in Notes Field in E-Prescriptions
The potential for errors leading to patient harm indicates a need for additional e-prescribing message fields, more adequate training, and better surveillance systems. *Medscape Medical News* from #ENT via xlomafota13 on Inoreader http://ift.tt/1UPtttA via IFTTT
Sudden onset of ptosis : Paget's disease of bone
Unusual presentation of Paget's disease of bone: Description A 60-year-old man presented with sudden onset of ptosis of the right eye. There was no history of headache, fever, altered sensorium, vision loss, trauma, diabetes or weakness of the limbs. On examination, there was right-sided third nerve palsy (figure 1). The rest of the neurological and systemic examination was normal. The patient's brain MRI was normal apart from pagetoid bony changes as evidenced by large well-defined lytic and sclerotic lesions in the skull along with diploic widening. Figure 1 Face of the patient s... περισσότερα »
Should the norepinephrine maximal dosage rate be greatly increased in late shock?
Should the norepinephrine maximal dosage rate be greatly increased in late shock?: Any advanced shock eventually degenerates into vasoplegia, which responds weakly to vasopressors. The highest reported norepinephrine flow rate is 3 μg/kg/min. We present the case of a young explosion victim, who was transferred in late haemorrhagic shock. Apart from usual treatment (hydration, mass transfusion protocol), single-agent norepinephrine was used to maintain a mean arterial pressure (MAP) of >60–65 mm Hg. For several hours, norepinephrine flow was 7–10 times the aforementioned (highest r... περισσότερα »
Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behcet's disease
Oral ulcerations after placement of orthodontic braces and skin pustules after laser hair removal: novel inducers of pathergy reactions in new-onset Behcet's disease: A 25-year-old man was admitted to our hospital, with fever, severe ulceration of the oral and pharyngeal mucosa, and pustules on his skin. These pathergy-like lesions had emerged after placement of orthodontic braces and laser therapy for hair removal, respectively. The patient's clinical condition, together with his ethnic background, pointed to the diagnosis of Behcet's disease. Treatment with colchicine and prednis... περισσότερα »
Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter
*Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter* Molecular Therapy 24, 508 (March 2016). doi:10.1038/mt.2016.7 Authors: Haiyan Ji, Zhengtao Jiang, Panpan Lu, Li Ma, Chuan Li, Hanyu Pan, Zheng Fu, Xiying Qu, Pengfei Wang, Junxiao Deng, Xinyi Yang, Jianhua Wang & Huanzhang Zhu from Cancer via ola Kala on Inoreader http://ift.tt/1TovGNc via IFTTT
In This Issue
*In This Issue* Molecular Therapy 24, 410 (March 2016). doi:10.1038/mt.2016.26 from Cancer via ola Kala on Inoreader http://ift.tt/1QI3E9u via IFTTT
Silent IL2RG Gene Editing in Human Pluripotent Stem Cells
*Silent IL2RG Gene Editing in Human Pluripotent Stem Cells* Molecular Therapy 24, 582 (March 2016). doi:10.1038/mt.2015.190 Authors: Li B Li, Chao Ma, Geneve Awong, Marion Kennedy, German Gornalusse, Gordon Keller, Dan S Kaufman & David W Russell from Cancer via ola Kala on Inoreader http://ift.tt/1TovGMX via IFTTT
Reversible cerebral vasoconstriction syndrome (RCVS): Sudden onset, throbbing headache associated with transient visual disturbance
Reversible cerebral vasoconstriction syndrome (RCVS): a transient condition being underdiagnosed?: Description A 68-year-old woman was admitted with a 6-day history of sudden onset, throbbing headache associated with transient visual disturbance. On examination, she exhibited right facial numbness and right arm heaviness. Her blood pressure was 207/88 mm Hg. Of note, she had a history of migraines and was taking sumatriptan. She was treated with antihypertensives and her symptoms improved. Initial brain CT was unremarkable. No angiogram was performed at the time. She further presen...περισσότερα »
Erythema gyratum repens: a paraneoplastic eruption
Erythema gyratum repens: a paraneoplastic eruption: Description A 77-year-old woman was evaluated for a 3-week history of rash on her lower limbs. The eruption began as a small erythematous macule, and gradually enlarged with time. The patient had atrial fibrillation on anticoagulation therapy. On physical examination, there were annular, erythematous lesions that appeared in concentric, raised bands lined by trailing edge of scales over the lateral aspect of her right thigh (figure 1). A clinical diagnosis of erythema gyratum repens was made. The remainder of her examination was re... περισσότερα »
Unilateral abducens and bilateral facial nerve palsies associated with posterior fossa exploration surgery
Unilateral abducens and bilateral facial nerve palsies associated with posterior fossa exploration surgery: Multiple cranial nerves palsies following a posterior fossa exploration confined to an extradural compartment is a rare clinical presentation. This case report describes a young man who developed a unilateral abducens and bilateral facial nerve palsies following a posterior fossa exploration confined to an extradural compartment. There are different theories to explain this presentation, but the exact mechanism remains unclear. We propose that this patient cranial nerve palsi... περισσότερα »
A fever of unknown origin
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report: [image: s13256-016-0833-7-5.gif] Background: Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling. There are no prior reports of giant cell tumor of bone with fever of unknown origin at the onset. Here we present a case of a secondary malignant giant cell tumor of bone due to malignant... περισσότερα »
Rising population of survivors of oral squamous cell cancer
Rising population of survivors of oral squamous cell cancer in the United States: [image: cover.gif?v=1&s=ac8254088193565bc910ec22] BACKGROUND The incidence of oropharyngeal cancer (OPC) and a subset of oral cavity cancer (OCC) is increasing in the United States. To the authors' knowledge, the presumed growing prevalence of survivors of OPC and OCC has not been investigated to date. METHODS Retrospective analysis of Surveillance, Epidemiology, and End Results data (1975-2012) estimated changes in incidence, 5-year cause-specific survival, and prevalence for OPC and OCC. Changes ...περισσότερα »
Therapeutic radiation and the potential risk of second malignancies
Therapeutic radiation and the potential risk of second malignancies: [image: cover.gif?v=1&s=ac8254088193565bc910ec22] Radiation has long been associated with carcinogenesis. Nevertheless, it is an important part of multimodality therapy for many malignancies. It is critical to assess the risk of secondary malignant neoplasms (SMNs) after radiation treatment. The authors reviewed the literature with a focus on radiation and associated SMNs for primary hematologic, breast, gynecologic, and pediatric tumors. Radiation appeared to increase the risk of SMN in all of these; however, ... περισσότερα »
A p16INK4a peptide vaccine in patients with advanced human papillomavirus-associated cancers
A phase 1/2a study to test the safety and immunogenicity of a p16INK4a peptide vaccine in patients with advanced human papillomavirus-associated cancers: BACKGROUND The cyclin-dependent kinase inhibitor p16INK4a is strongly and consistently overexpressed in all human papillomavirus (HPV)-associated cancers. Therefore, the authors hypothesized that p16INK4a may be a vaccine target antigen for HPV-associated cancers. To test this hypothesis, the authors performed a phase 1/2a first-in-human trial to evaluate the safety and immunogenicity of a p16INK4a-based peptide vaccine. METHODS A... περισσότερα »
Personalized Medicine in Melanoma
Personalized Medicine in Melanoma [Research Articles]: Targeted therapies and immunotherapies have transformed melanoma care, extending median survival from ~9 to over 25 months, but nevertheless most patients still die of their disease. The aim of precision medicine is to tailor care for individual patients and improve outcomes. To this end, we developed protocols to facilitate individualized treatment decisions for patients with advanced melanoma, analyzing 364 samples from 214 patients. Whole exome sequencing (WES) and targeted sequencing of circulating tumor DNA (ctDNA) allowed... περισσότερα »
Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma
Characterization of functionally active gene fusions in human papillomavirus related oropharyngeal squamous cell carcinoma: [image: cover.gif?v=1&s=6f61b81a7f6bfc314e70fdfe] ABSTRACT The Cancer Genome Atlas (TCGA) sequencing analysis of head and neck squamous cell carcinoma (HNSCC) recently reported on gene fusions, however few human papillomavirus (HPV) positive samples were included, and the functional relevance of identified fusions was not explored. We therefore performed an independent analysis of gene fusions in HPV-positive oropharyngeal SCC (OPSCC). RNA sequencing was pe... περισσότερα »
Early volumetric edema increase following stereotactic radiosurgery for brain metastases
What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases?: AbstractA volumetric analysis of pre- and post-radiosurgery (PreSRS and PostSRS) edema in patients with cerebral metastases was performed to determine factors of a predictive model assessing the risk of developing increased edema relatively early after SRS. One-hundred-fourteen metastases in 55 patients were analyzed. Selection for this analysis required an MRI ≤ 30 days before SRS and an MRI ≤ 100 days after SRS. Tumor volumes were calculated on PreSRS, SRS, and PostSRS T1-weig...περισσότερα »
Reirradiation of spinal metastases
Overall survival after reirradiation of spinal metastases – independent validation of predictive models: Abstract BackgroundIt is unknown if survival prediction tools (SPTs) sufficiently predict survival in patients who undergo palliative reirradiation of spinal metastases. We therefore set out to clarify if SPTs can predict survival in this patient population. MethodsWe retrospectively analyzed spinal reirradiations performed (*n* = 58, 52 patients, 44 included in analysis). SPTs for patients with spinal metastases were identified and compared to a general palliative score and... περισσότερα »
Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy
Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy: Abstract BackgroundThe Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting native cellular MRN function would sensitize NPC cells to IR. MethodsA recombinant adenovirus containing a mutant Rad50 gene (Ad-RAD50) expressing Rad50 zinc hook domain but lacking the ATPase dom...περισσότερα »
The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial
The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial: Abstract BackgroundRadiation therapy is the method of choice for subjects with inoperable salivary gland malignancies. I-125 brachytherapy, delivering a high radiation dose to a tumor but sparing surrounding normal tissues, is supposed to be ideal modality for the treatment of salivary gland malignancies. We designed a randomised controlled clinical trial to compare the efficacy of I-125 permanent brach...περισσότερα »
Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma
Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma: Abstract BackgroundThe radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage... περισσότερα »
Anatomy of trapezius muscle innervation by spinal accessory nerve and C2 to C4 nerves of cervical plexus
Topographical and functional anatomy of trapezius muscle innervation by spinal accessory nerve and C2 to C4 nerves of cervical plexus: AbstractThe aim of this study was to determine the existence and the frequency of communicating branches between the spinal accessory nerve (SAN) and the C2, C3 and C4 roots of the cervical plexus. The present study also aimed to elucidate whether these branches contain motor fibers or not. Dissection of the cervical region was performed on twelve adult cadavers. A powered operating microscope was necessary to dissect the SAN and its branches and al...περισσότερα »
Prähospitale Analgesie beim Erwachsenen – Schmerzerfassung und Therapieoptionen
Prähospitale Analgesie beim Erwachsenen – Schmerzerfassung und Therapieoptionen: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 84-96 DOI: 10.1055/s-0042-101466 Nach der Sicherung der Vitalfunktionen ist die Schmerztherapie ein wichtiger Faktor der notfallmedizinischen Versorgung. Unabhängig von der zugrunde liegenden Erkrankung oder Verletzung ist Schmerz ein wichtiges Warnsymptom des Körpers und der häufigste Grund für eine Notarztalarmierung. Als Maß der Versorgungsqualität und Erfolgskriterium für die prähospitale Versorgung beurteilt der Patient das Ausmaß der Schme... περισσότερα »
Multiresistente Erreger – Prävention und Diagnostik
Multiresistente Erreger – Prävention und Diagnostik: Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 112-120 DOI: 10.1055/s-0041-103142 Multiresistente Keime spielen im klinischen Alltag eine zunehmend bedeutsame Rolle. Dieses besonders auf Intensivstationen bzw. in Risikobereichen. Oftmals herrschen Unklarheiten bezüglich diagnostischer Screening-Indikationen und Strategien zur Vermeidung von Übertragungen mittels Hygiene- und Isolierungsmaßnahmen. Wir geben einen orientierenden Überblick über die zur Zeit gängigen Empfehlungen und bewerten diese für Methicillin-resistent...περισσότερα »
Aesthetic and Functional Rhinoplasty: The RHINO Scale
A Comprehensive Quality-of-Life Instrument for Aesthetic and Functional Rhinoplasty: The RHINO Scale: Background: Currently, there is no validated quality-of-life instrument that evaluates both functional and aesthetic outcomes after rhinoplasty. The goal of this study was to develop and validate a comprehensive quality-of-life instrument to assess patient satisfaction with both functional and aesthetic outcomes after rhinoplasty. Methods: The study was designed as a prospective instrument validation study at a university-affiliated academic medical center. Inclusion criteria incl...περισσότερα »
Microcirculatory Evaluation of the Abdominal Skin
Microcirculatory Evaluation of the Abdominal Skin in Breast Reconstruction with Deep Inferior Epigastric Artery Perforator Flap: [image: image] Background: No studies have assessed the perfusion of the undermined abdominal skin in breast reconstruction with deep inferior epigastric artery perforator flap. A greater understanding of the procedure’s impact on the perfusion of the abdominal skin can be valuable in predicting areas susceptible to necrosis. Methods: Microcirculatory changes were monitored in the abdominal skin of 20 consecutive patients undergoing breast reconstruction ... περισσότερα »
Optimizing Reconstruction with Periorbital Transplantation
Optimizing Reconstruction with Periorbital Transplantation: Clinical Indications and Anatomic Considerations: Background: Complex periorbital subunit reconstruction is challenging because the goals of effective reconstruction vary from one individual to another. The purpose of this article is to explore the indications and anatomic feasibility of periorbital transplantation by reviewing our institutional repository of facial injury. Methods: Institutional review board approval was obtained at the R Adams Cowley Shock Trauma Center for a retrospective chart review conducted on patie... περισσότερα »
Tissue Expander Overfilling
Tissue Expander Overfilling: Achieving New Dimensions of Customization in Breast Reconstruction: Introduction: Overfill of tissue expanders is a commonly used modality to achieve customized dimensions in breast reconstruction. Little formal study of the dynamics of hyperexpansion of these devices has been performed to date, however. Methods: Overfill trials were performed using both Natrelle 133 MV and Mentor 8200 tissue expanders of indicated capacities ranging from 250 to 800 mL. Each expander was initially filled to its indicated capacity with normal water and then injected in re... περισσότερα »
Transmaxillary Sinus Approach for Le Fort II Osteotomy
Transmaxillary Sinus Approach for Le Fort II Osteotomy: [image: image] Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer s... περισσότερα »
Stein’s Double Cross-Lip Flaps Combined with Johanson’s Step Technique for Subtotal Lower Lip Reconstruction
Stein’s Double Cross-Lip Flaps Combined with Johanson’s Step Technique for Subtotal Lower Lip Reconstruction: [image: image]Background: In a previous study, a single cross-lip flap (Abbe flap) combined with Johanson’s step technique for repair of defects of more than 2/3 of the lower lip was superior, in terms of aesthetic and functional outcome, compared with Bernard Webster–related techniques (cheek advancement). Herewith, a double cross-lip flap (Stein procedure) is proposed for repair of subtotal lower lip defects. A systematic review of the Stein procedure is provided. Methods:... περισσότερα »
Usefulness of Titanized Polypropylene Mesh and an Anchor System for Correction of Lower Lid Retraction
Usefulness of Titanized Polypropylene Mesh and an Anchor System for Correction of Lower Lid Retraction: [image: image]Summary: Because of the lower eyelid’s free edge anatomy, it is difficult to preserve its contours after reconstruction. We recently attempted a new operative procedure to treat 2 cases of lower lid retraction by using a titanized polypropylene mesh and an anchor system. As the lower lid skin is elevated laterally in an oblique upward direction, the location of the mesh insertion is decided and the site is marked accordingly. The mesh to be inserted is approximately ... περισσότερα »
Efficacious Healing of Ulcerated Infantile Hemangiomas Using Topical Timolol
Efficacious Healing of Ulcerated Infantile Hemangiomas Using Topical Timolol: Summary: Infantile hemangiomas (IHs) are the most common benign pediatric soft-tissue tumors. Ulceration—the most frequent complication of IH—tends to heal poorly and is associated with pain, bleeding, infection, and scarring. Mainstay treatment modalities include propranolol (β-blocker) and corticosteroids, whose effectiveness is countered by a need for long-term medication and risk of systemic adverse effects and ulcer recurrence. A 3-month-old infant presented to us with a large, medial thigh-ulcerated I...περισσότερα »
Giant Congenital Sclerosing Blue Nevus of the Scalp Presenting with Rapidly Disseminated Fatal Metastases in a Pediatric Patient
Giant Congenital Sclerosing Blue Nevus of the Scalp Presenting with Rapidly Disseminated Fatal Metastases in a Pediatric Patient: [image: image] Sir: Giant congenital blue nevi (GCBN) are rare dermal melanocytic proliferations that are distinguished by their large size, aggressive behavior, and propensity for malignant degeneration.1 To date, only 18 cases of GCBN involving the scalp have been reported. Among these, local invasion into the calvaria/dura (n = 10), malignant transformation (n = 6), and disseminated metastases (n = 5) were observed.2Although the precise nature of mal...περισσότερα »
Exploiting redox activity in metal-organic frameworks: concepts, trends and perspectives
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00805D, Feature Article Deanna Michelle D'Alessandro the many thousands of new metal-organic frameworks (MOFs) that are now discovered each year, many possess potential redox activity arising from the constituent metal ions and/or organic ligands, or the... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1pcSnrf via IFTTT
Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC01744D, Communication Arindam Banerjee, Kingshuk Basu, Abhishek Baral, Shibaji Basak, Ashkan Dehsorkhi, Jayanta Nanda, Debmalya Bhunia, Surajit Ghosh, Valeria Castelletto, Ian Hamley Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChe...περισσότερα »
Metal Catalyst-free Substitution of Allylic and Propargylic Phosphates with Diarylmethyl Anions
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC00024J, Communication Hidehisa Kawashima, Narihito Ogawa, Ryohei Saeki, Yuichi Kobayashi Substitution of secondary allylic phosphates with the anions derived from Ar2CH2 with BuLi or LDA proceeded regioselectively and stereoselectively without a metal catalyst, affording inversion products in good yield. Similarly,... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/1pcSnaP via IFTTT
Congenital Palatal Fistula Associated with Submucous Cleft Palate
Congenital Palatal Fistula Associated with Submucous Cleft Palate: [image: image]Background: Although cleft lip and cleft palate are among the most common congenital malformations, the presence of an isolated congenital palatal fistula along with a submucous cleft is very rare. This appears as an oval-shaped, full-thickness fenestration in the palatal midline that does not fully extend anteriorly or posteriorly, accompanied by the findings of a submucous cleft. Because of the uncommon nature of this entity, there is controversy about its etiology, diagnosis, and management. Metho... περισσότερα »
Keystone Island Flap: Effects of Islanding on Vascularity
Keystone Island Flap: Effects of Islanding on Vascularity: [image: image]Background: Based on his clinical observations the “red dot sign” and hyperemic flare, Behan has advocated the superior vascularity of the island flap design for at least 2 decades. The aim of this study was to determine whether (1) surgical islanding of a flap alters the vascularity or blood supply of the flap and (2) these changes in blood supply explain Behan’s clinical observations of “red dot sign” and hyperemic flare. Methods: Patients undergoing local island fasciocutaneous flaps or anterolateral thigh f... περισσότερα »
Immunological Characterization of Dutch Sesame Seed-Allergic Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Background: Sesame seed is an allergen of growing importance worldwide. However, knowledge of the clinically relevant sesame allergen and its cross-reactivity with homologous allergens is limited. The aim of this study was the immunological characterization of Dutch sesame seed-allergic patients and evaluation of cross-reactivity between sesame seed, tree nut and pollen allergens using different sources […]
The ADAPAR Birth Cohort Study: Food Allergy Results at Five Years and New Insights
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Background: Although food allergy (FA) is often a transient condition during childhood, when and in whom FA will resolve can be affected by many factors. In this study, we analyzed the data at 5 years on 33 children diagnosed with FA in the ADAPAR (Adana Pediatric Allergy Research) birth cohort study in southern Turkey. Methods: […]
Proven Non-β-Lactam Antibiotic Allergy in Children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Background: Parallel to the increasing use of non-β-lactam (NBL) antibiotics, allergic reactions to this drug group seem to increase. Data about NBL antibiotic hypersensitivity in children are limited. The aim of this study is to evaluate characteristic reactions to NBL antibiotics in children. Method: Patients with suspected NBL allergy were assessed between 2011 and 2015. […]
Circulating fibrocytes as predictors of adverse events in unstable angina
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Publication date: Available online 8 March 2016 Source:Translational Research Author(s): Ellen C. Keeley, Robert C. Schutt, Mark A. Marinescu, Marie D. Burdick, Robert M. Strieter, Borna Mehrad Half of the patients who present with unstable angina (UA) develop recurrent symptoms over the subsequent year. Identification of patients destined to develop such adverse events would be […]
A flexible fast spin echo triple-echo Dixon technique
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Purpose To develop a flexible fast spin echo (FSE) triple-echo Dixon (FTED) technique. Methods An FSE pulse sequence was modified by replacing each readout gradient with three fast-switching bipolar readout gradients with minimal interecho dead time. The corresponding three echoes were used to generate three raw images with relative phase shifts of −θ, 0, and […]
Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Ampullary cancer is a relatively rare form of cancer and usually treated by pancreatoduodenectomy, followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. At present, only few cell lines are available for in vitro studies of ampullary cancer and they have not been collectively characterized. Methods We […]
Snail heterogeneity in clear cell renal cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, leaving out of histological analysis foci of high grade tumor areas. Although molecular approaches are providing important information on renal intratumor heterogeneity, a focus on […]
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Alcohol consumption is one of the major risk factors for colorectal cancer. However, the mechanism involved in this effect of alcohol is unknown. Methods We evaluated the effect of chronic ethanol feeding on azoxymethane and dextran sulfate sodium (AOM/DSS)-induced carcinogenesis in mouse colon. Inflammation in colonic mucosa was assessed at a precancerous stage […]
Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 […]
The efficacy of iodine-125 permanent brachytherapy versus intensity-modulated radiation for inoperable salivary gland malignancies: study protocol of a randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Abstract Background Radiation therapy is the method of choice for subjects with inoperable salivary gland malignancies. I-125 brachytherapy, delivering a high radiation dose to a tumor but sparing surrounding normal tissues, is supposed to be ideal modality for the treatment of salivary gland malignancies. We designed a randomised controlled clinical trial to compare the efficacy […]
Silicone-induced Granuloma
Silicone-induced Granuloma After Buttock Augmentation: [image: image]Summary: Liquid silicone is inexpensive, minimally antigenic, and likely noncarcinogenic. Its simplicity of use has made it popular as a soft-tissue filler in some parts of the world for patients seeking rapid soft-tissue augmentation of the face, breast, and buttocks. However, multiple reports describe the complications of silicone injections such as cellulitis, abscess, ulceration, and foreign body migration. We present an unusual complication of granulomatous reaction secondary to silicone injection for buttock ... περισσότερα »
Bone Graft Harvesting from the Olecranon Process and the Distal Radius
Comparing Morbidities of Bone Graft Harvesting from the Olecranon Process and the Distal Radius: Background: The aim of this study is to compare donor-site morbidities between patients who underwent bone graft harvesting from either the olecranon process (OP) or the distal radius (DR). Methods: We evaluated 44 patients who underwent bone graft harvesting from the OP (25 cases) or the DR (19 cases) for various procedures in the ipsilateral upper extremity. Follow-up averaged 14 (OP group) and 19 months (DR group). Outcome measures included visual analog scales (VAS) for graft harve...περισσότερα »
Spatial plasticity of the auditory cortex in single-sided deafness
Spatial plasticity of the auditory cortex in single-sided deafness: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To evaluate spatial plasticity of the auditory cortex in single-sided deafness (SSD). Study Design Cross-sectional study comparing a cohort with adult-onset, idiopathic SSD to a cohort with normal hearing. Methods Demographic, audiometric, magnetoencephalographic imaging, and magnetic resonance imaging data were collected for 13 SSD adult subjects and 13 normal-hearing controls. Locations of peak activation corresponding to the M100 response ... περισσότερα »
Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns
Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns: Summary The rate of lymph-node (LN) metastasis in early adenocarcinoma (EAC) of the esophagus with mid to deep submucosal invasion (pT1b sm2/3) has not yet been precisely defined. The aim of the this study was to evaluate the rate of LN metastasis in pT1b sm2/3 EAC depending on macroscopic and histological risk patterns to find out whether there may also be options for endoscopic therapy as in ca...περισσότερα »
Esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter
Interference with daily activities and major adverse events during esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter: a systematic review of randomized controlled trials: Summary For three decades, ambulatory 24-hour intranasal pH monitoring has been the established gold standard for detecting acid reflux in patients with refractory gastroesophageal reflux disease. However, device-associated adverse events and unpleasant experiences, reported by patients during pH monitoring have led to the invention of more convenient pH monitors such as ... περισσότερα »
The Immunology of Neuromyelitis Optica-Current Knowledge, Clinical Implications, Controversies and Future Perspectives.
*The Immunology of Neuromyelitis Optica-Current Knowledge, Clinical Implications, Controversies and Future Perspectives.* Int J Mol Sci. 2016;17(3) Authors: Jasiak-Zatonska M, Kalinowska-Lyszczarz A, Michalak S, Kozubski W Abstract Neuromyelitis optica (NMO) is an autoimmune, demyelinating disorder of the central nervous system (CNS) with typical clinical manifestations of optic neuritis and acute transverse myelitis attacks. Previously believed to be a variant of multiple sclerosis (MS), it is now considered an independent disorder which needs to be differentiated from MS. The di...περισσότερα »
Car-driven regeneration protects liver from failure following tissue loss and bears therapeutic potential.
*Car-driven regeneration protects liver from failure following tissue loss and bears therapeutic potential.* J Hepatol. 2016 Mar 3; Authors: Tschuor C, Kachaylo E, Perparim L, Raptis DA, Linecker M, Tian Y, Herrmann U, Grabliauskaite K, Weber A, Columbano A, Graf R, Humar B, Clavien PA Abstract BACKGROUND & AIMS: Liver can recover following resection. If tissue loss is too excessive, however, liver failure will develop as is known from the Small-for-Size-Syndrome (SFSS). The molecular processes underlying liver failure are ill-understood. Here, we explored the role and the clinic... περισσότερα »
Astrocytic gliomas WHO grades II and III.
*Astrocytic gliomas WHO grades II and III.* Handb Clin Neurol. 2016;134:345-60 Authors: Berger MS, Hervey-Jumper S, Wick W Abstract World Health Organization grades II and III lower-grade astrocytomas are a challenging area in neuro-oncology. One the one hand, for proper diagnosis, the analysis of molecular factors, especially mutation status of isocitrate dehydrogenase and 1p/19q status in the tumor status needs to be done in addition to classical neuropathology. Further, the high clinical and prognostic value of a maximal safe resection requires a profound knowledge of presurgi... περισσότερα »
Molecular classification of gliomas.
*Molecular classification of gliomas.* Handb Clin Neurol. 2016;134:97-120 Authors: Masui K, Mischel PS, Reifenberger G Abstract The identification of distinct genetic and epigenetic profiles in different types of gliomas has revealed novel diagnostic, prognostic, and predictive molecular biomarkers for refinement of glioma classification and improved prediction of therapy response and outcome. Therefore, the new (2016) World Health Organization (WHO) classification of tumors of the central nervous system breaks with the traditional principle of diagnosis based on histologic crite... περισσότερα »
Evaluation of glioblastomas and lymphomas with whole-brain CT perfusion: Comparison between a delay-invariant singular-value decomposition algorithm and a Patlak plot.
*Evaluation of glioblastomas and lymphomas with whole-brain CT perfusion: Comparison between a delay-invariant singular-value decomposition algorithm and a Patlak plot.* J Neuroradiol. 2016 Mar 2; Authors: Hiwatashi A, Togao O, Yamashita K, Kikuchi K, Yoshimoto K, Mizoguchi M, Suzuki SO, Yoshiura T, Honda H Abstract OBJECTIVE: Correction of contrast leakage is recommended when enhancing lesions during perfusion analysis. The purpose of this study was to assess the diagnostic performance of computed tomography perfusion (CTP) with a delay-invariant singular-value decomposition alg...περισσότερα »
Mutation in the caveolin-3 gene causes asymmetrical distal myopathy.
*Mutation in the caveolin-3 gene causes asymmetrical distal myopathy.* Neuropathology. 2016 Mar 7; Authors: Chen J, Zeng W, Han C, Wu J, Zhang H, Tong X Abstract Mutations in the gene encoding caveolin-3 (CAV3) can cause a broad spectrum of clinical phenotypes, including limb girdle muscular dystrophy, rippling muscle disease, distal myopathy (MD), idiopathic persistent elevation of serum creatine kinase and cardiomyopathy. MD is a relatively rare subtype of caveolinopathy. Here, we report a sporadic case of a middle-aged female Chinese patient with MD in which a CAV3 mutation was... περισσότερα »
In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.
Related Articles *In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.* Ann Neurol. 2016 Mar 6; Authors: Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B Abstract OBJECTIVE: Neuromyelitis optica (NMO) is an autoimmune disease of the CNS, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients ca...περισσότερα »
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.
*A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.* Cancer Cell. 2016 Mar 1; Authors: Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C Abstract Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenograf...περισσότερα »
Total, dietary, and supplemental calcium intake and mortality from all-causes, cardiovascular disease, and cancer: A meta-analysis of observational studies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Total, dietary, and supplemental calcium intake and mortality from all-causes, cardiovascular disease, and cancer: A meta-analysis of observational studies.* Nutr Metab Cardiovasc Dis. 2015 Jul;25(7):623-34 Authors: Asemi Z, Saneei P, Sabihi SS, Feizi A, Esmaillzadeh A Abstract AIMS: This systematic review and meta-analysis of observational studies was conducted to summarize the evidence on the association between calcium intake and mortality. METHODS AND RESULTS: PubMed, Institute for Scientific Information (ISI)... περισσότερα »
Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway.
*Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway.* Oncotarget. 2016 Feb 29; Authors: Wang YJ, Ren QG, Gong WG, Wu D, Tang X, Li XL, Wu FF, Bai F, Xu L, Zhang ZJ Abstract Tau hyperphosphorylation is an important pathological feature of Alzheimer's disease (AD). To investigate whether escitalopram could inhibit amyloid-β (Aβ)-induced tau hyperphosphorylation and the underlying mechanisms, we treated the rat primary hippocampal neurons with Aβ1-42 and examined the effect of esc...περισσότερα »
Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.
*Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.* Oncotarget. 2016 Feb 29; Authors: Cao L, Wang HF, Tan L, Sun FR, Tan MS, Tan CC, Jiang T, Yu JT, Tan L, Alzheimer's Disease Neuroimaging Initiative Abstract Alzheimer's disease (AD) has become a considerable public health issue. The mechanisms underlying AD onset and progression remain largely unclear. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is a strong functional AD candidate gene because it encodes part of the statin-binding domai... περισσότερα »
High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.
*High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.* Oncotarget. 2016 Feb 29; Authors: Hoda MA, Rozsas A, Lang E, Klikovits T, Lohinai Z, Torok S, Berta J, Bendek M, Berger W, Hegedus B, Klepetko W, Renyi-Vamos F, Grusch M, Dome B, Laszlo V Abstract Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in different tumor types including lung adenocarcinoma (LADC). Here, we report that serum ActA protein levels are significantly elevated in LADC patients (n=64) as compared to controls (n... περισσότερα »
High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid.
*High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid.* Oncotarget. 2016 Feb 29; Authors: Wu W, Zhu H, Fu Y, Shen W, Miao K, Hong M, Xu W, Fan L, Young KH, Liu P, Li J Abstract Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). As a key transcription factor of the Wnt/β-catenin pathway, LEF1 helps to regulate important genes involved in tumor cell death mechanisms. In this study, we determined LEF1 gene expression le...περισσότερα »
Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?
*Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?* Oncotarget. 2016 Feb 29; Authors: Coelho AL, Gomes MP, Catarino RJ, Rolfo C, Lopes AM, Medeiros RM, Araújo AM Abstract The critical role of angiogenesis in tumor development makes its inhibition a valuable new approach in therapy, rapidly making anti-angiogenesis a major focus in research. While the VEGF/VEGFR pathway is the main target of the approved anti-angiogenic molecules in NSCLC treatment, the results obtained are still modest, especially due to resistance mechanisms. Accumulating scientif... περισσότερα »
Perspectives for immunotherapy: which applications might achieve an HIV functional cure?
*Perspectives for immunotherapy: which applications might achieve an HIV functional cure?* Oncotarget. 2016 Feb 29; Authors: Vieillard V, Gharakhanian S, Lucar O, Katlama C, Launay O, Autran B, Tsong Fang RH, Crouzet J, Murphy RL, Debré P Abstract The major advances achieved in devising successful combined antiretroviral therapy (cART) have enabled the sustained control of HIV replication. However, this is associated with costly lifelong treatment, partial immune restoration, chronic inflammation and persistent viral reservoirs. In this context, new therapeutic strategies deserve...περισσότερα »
Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma.
*Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma.* Oncotarget. 2016 Feb 29; Authors: Wang J, Faict S, Maes K, De Bruyne E, Van Valckenborgh E, Schots R, Vanderkerken K, Menu E Abstract The bone marrow (BM) represents a complex microenvironment containing stromal cells, immune cells, osteoclasts, osteoblasts, and hematopoietic cells, which are crucial for the immune response, bone formation, and hematopoiesis. Apart from soluble factors and direct cell-cell contact, extracellular vesicles (EVs), including exosomes, were recent... περισσότερα »
L1 in tumor vasculature.
*L1 in tumor vasculature.* Oncotarget. 2016 Feb 29; Authors: Cavallaro U PMID: 26950272 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1UPs3PA via IFTTT
Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro.
*Establishment and characterization of a transplantable tumor line (RMM) and cell line (RMM-C) from a malignant amelanotic melanoma in the F344 rat, with particular reference to galectin-3 expression in vivo and in vitro.* Histol Histopathol. 2016 Mar 7;:11748 Authors: Bondoc A, Katou-Ichikawa C, Golbar HM, Tanaka M, Izawa T, Kuwamura M, Yamate J Abstract To investigate characteristics of malignant melanomas with various pathobiological features, a homotransplantable tumor line (RMM) was established from a spontaneous amelanotic melanoma found in the pinna of an aged F344 rat. RM... περισσότερα »
Nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with sleep-disordered breathing (SDB)
Sleep-disordered breathing children: Abstract ObjectiveTo assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with sleep-disordered breathing (SDB). MethodsEnrolled in this study were 30 children with SDB and 15 healthy children. The nNO and FeNO concentrations were measured noninvasively using a NIOX MINO system (Aerocrine AB, Solna, Sweden). SPSS statistics 20.0 software (IBM SPSS statistics 20.0, Armonk, NY, USA) was used to analyze the data. ResultsThe median (25th and 75th percentiles) nNO c...περισσότερα »
Sleep-disordered breathing children
Sleep-disordered breathing children: Abstract ObjectiveTo assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with sleep-disordered breathing (SDB). MethodsEnrolled in this study were 30 children with SDB and 15 healthy children. The nNO and FeNO concentrations were measured noninvasively using a NIOX MINO system (Aerocrine AB, Solna, Sweden). SPSS statistics 20.0 software (IBM SPSS statistics 20.0, Armonk, NY, USA) was used to analyze the data. ResultsThe median (25th and 75th percentiles) nNO con... περισσότερα »
Mazabraud's syndrome and thyroid cancer, a very rare and confusing association: a case report.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Mazabraud's syndrome and thyroid cancer, a very rare and confusing association: a case report.* BMC Endocr Disord. 2015;15:39 Authors: Piciu D, Barbus E, Piciu A, Fetica B Abstract BACKGROUND: Mazabraud's syndrome is defined as the association between fibrous dysplasia and intramuscular myxomas. The syndrome was first described in 1967 and, up until now, less than 100 cases have been reported worldwide. Here we report the association between this rare syndrome and thyroid cancer. When a... περισσότερα »
Thyroid Hormones, Oxidative Stress, and Inflammation
Inflammation and oxidative stress (OS) are closely related processes, as well exemplified in obesity and cardiovascular diseases. OS is also related to hormonal derangement in a reciprocal way. Among the various hormonal influences that operate on the antioxidant balance, thyroid hormones play particularly important roles, since both hyperthyroidism and hypothyroidism have been shown to be associated with OS in animals and humans. In this context, the nonthyroidal illness syndrome (NTIS) that typically manifests as reduced conversion of thyroxine (T4) to triiodothyronine (T3) in d... περισσότερα »
Association of BRAF(V600E) Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers.
*Association of BRAF(V600E) Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers.* Thyroid. 2016 Mar 7; Authors: Aragon Han P, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA Abstract BACKGROUND: Studies have demonstrated an association of the BRAF(V600E) mutation and microRNA (miR) expression with a... περισσότερα »
Occupation and Thyroid Cancer: A Population-Based, Case-Control Study in Connecticut.
*Occupation and Thyroid Cancer: A Population-Based, Case-Control Study in Connecticut.* J Occup Environ Med. 2016 Mar;58(3):299-305 Authors: Ba Y, Huang H, Lerro CC, Li S, Zhao N, Li A, Ma S, Udelsman R, Zhang Y Abstract OBJECTIVE: The study aims to explore the associations between various occupations and thyroid cancer risk. METHODS: A population-based, case-control study involving 462 histologically confirmed incident cases and 498 controls was conducted in Connecticut in 2010 to 2011. RESULTS: A significantly increased risk of thyroid cancer, particularly papillary microcarcin... περισσότερα »
Nodal metastases in thyroid cancer: prognostic implications and management.
*Nodal metastases in thyroid cancer: prognostic implications and management.* Future Oncol. 2016 Mar 7; Authors: Wang LY, Ganly I Abstract The significance of cervical lymph node metastases in differentiated thyroid cancer has been controversial and continues to evolve. Current staging systems consider nodal metastases to confer a poorer prognosis, particularly in older patients. Increasingly, the literature suggests that characteristics of the metastatic lymph nodes such as size and number are also prognostic. There is a growing trend toward less aggressive treatment of low-vol... περισσότερα »
Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?
*Split-field vs extended-field intensity-modulated radiation therapy plans for oropharyngeal cancer: Which spares the larynx? Which spares the thyroid?* Med Dosim. 2016 Mar 2; Authors: Yu Y, Chen J, Leary CI, Shugard E, Yom SS Abstract Radiation of the low neck can be accomplished using split-field intensity-modulated radiation therapy (sf-IMRT) or extended-field intensity-modulated radiation therapy (ef-IMRT). We evaluated the effect of these treatment choices on target coverage and thyroid and larynx doses. Using data from 14 patients with cancers of the oropharynx, we compared... περισσότερα »
Solitary thyroid metastasis from colon cancer: fine-needle aspiration cytology and molecular biology approach.
*Solitary thyroid metastasis from colon cancer: fine-needle aspiration cytology and molecular biology approach.* Pathologica. 2015 Sep-Dec;107(3-4):192-6 Authors: Onorati M, Uboldi P, Bianchi CL, Nicola M, Corradini GM, Veronese S, Fascì AI, Di Nuovo F Abstract Thyroid gland is one of the most vascularized organs of the body, nevertheless clinical and surgical series report an incidence of secondary malignancies in this gland of only 3%. Colorectal carcinoma metastatic to the thyroid gland is not as uncommon as previously believed, infact the number of cases seems to be increased...περισσότερα »
18F-FDG PET/CT demonstrating response to targeted therapy in synchronous metastatic adenocarcinoma of the lung and poorly differentiated carcinoma of the thyroid.
Related Articles *18F-FDG PET/CT demonstrating response to targeted therapy in synchronous metastatic adenocarcinoma of the lung and poorly differentiated carcinoma of the thyroid.* Natl Med J India. 2015 May-Jun;28(3):155 Authors: Kumar NS, Basu S PMID: 26724353 [PubMed - indexed for MEDLINE] from pubmed: thyroid cancer http://ift.tt/1THbTJh via IFTTT
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Related Articles *Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.* Cancer Treat Rev. 2015 Dec;41(10):925-34 Authors: Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM Abstract BACKGROUND: Treatment of differentiated thyroid carcinoma (DTC) often involves administration of radioactive iodine (I-131) for remnant ablation or adjuvant therapy. As DTC has favorable outcome and the ... περισσότερα »
Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method.
Related Articles *Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method.* Int J Clin Exp Pathol. 2015;8(2):1535-44 Authors: Zhao J, Fan YX, Yang Y, Liu DL, Wu K, Wen FB, Zhang CY, Zhu DY, Zhao S Abstract Among malignant tumors, the mortality rate of esophageal squamous cell carcinoma (ESCC) ranks sixth in the world. Late-stage diagnosis of ESCC increases the mortality. Therefore, more effective biomarkers for early diagnosis of ESCC are necessary. Unfortunately, appropriate biomarkers for clinical diagnosis and prognosis have ... περισσότερα »
Bax inhibitor-1 is overexpressed in non-small cell lung cancer and promotes its progression and metastasis.
Related Articles *Bax inhibitor-1 is overexpressed in non-small cell lung cancer and promotes its progression and metastasis.* Int J Clin Exp Pathol. 2015;8(2):1411-8 Authors: Lu B, Li Y, Li H, Zhang Y, Xu J, Ren L, Fu S, Zhou Y Abstract Bax inhibitor-1 (BI-1) is a novel anti-apoptotic protein. While the effect of BI-1 on apoptosis has been extensively studied, less is known about how BI-1 is related to oncogenesis and the progression, particularly, the invasion and metastasis of cancer. In this study, we investigated the expression and function of BI-1 in human non-small cell lu... περισσότερα »
Sonographically based diagnosis of contralateral malignancy in preoperative patients with papillary thyroid microcarcinoma.
Related Articles *Sonographically based diagnosis of contralateral malignancy in preoperative patients with papillary thyroid microcarcinoma.* J Ultrasound Med. 2015 May;34(5):789-95 Authors: Kim DW, Park HK, Ha TK, Kim SH, Jung SJ, Kim do H, Bae SK Abstract OBJECTIVES: We aimed to assess the usefulness of sonographically based diagnosis to predict whether contralaterally located dominant thyroid nodules are malignant or benign in patients with known papillary thyroid microcarcinoma. METHODS: We studied 143 patients with primary papillary thyroid microcarcinoma who underwent preo... περισσότερα »
Diagnosis and Clinical Course of Unexplained Dysphagia.
*Diagnosis and Clinical Course of Unexplained Dysphagia.* Ann Rehabil Med. 2016 Feb;40(1):95-101 Authors: Yeom J, Song YS, Lee WK, Oh BM, Han TR, Seo HG Abstract OBJECTIVE: To investigate the final diagnosis of patients with unexplained dysphagia and the clinical and laboratory findings supporting the diagnosis. METHODS: We retrospectively analyzed 143 patients with dysphagia of unclear etiology who underwent a videofluoroscopic swallowing study (VFSS). The medical records were reviewed, and patients with a previous history of diseases that could affect swallowing were categorized ... περισσότερα »
The Relation Between the Presence of Aspiration or Penetration and the Clinical Indicators of Dysphagia in Poststroke Survivors.
*The Relation Between the Presence of Aspiration or Penetration and the Clinical Indicators of Dysphagia in Poststroke Survivors.* Ann Rehabil Med. 2016 Feb;40(1):88-94 Authors: Han H, Shin G, Jun A, Park T, Ko D, Choi E, Kim Y Abstract OBJECTIVE: To examine the relation between the presence of penetration or aspiration and the occurrence of the clinical indicators of dysphagia. The presence of penetration or aspiration is closely related to the clinical indicators of dysphagia. It is essential to understand these relationships in order to implement proper diagnosis and treatment ... περισσότερα »
Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis.* Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1579-81 Authors: Tompkins JJ, Vaughn CA, Shaikh FA, Stocks RM, Thompson JW Abstract Oropharyngeal stenosis is rare, but known complication from tonsillectomy procedure. A 15-year-old female presented with refractory dyspnea, mild obstructive sleep apnea, and dysphagia. She underwent tonsillectomy 3 years prior. Severe cicatricial oropharyngeal scar involving soft pala... περισσότερα »
Viruses, Vol. 8, Pages 64: Recycling Endosomes and Viral Infection
Many viruses exploit specific arms of the endomembrane system. The unique composition of each arm prompts the development of remarkably specific interactions between viruses and sub-organelles. This review focuses on the viral–host interactions occurring on the endocytic recycling compartment (ERC), and mediated by its regulatory Ras-related in brain (Rab) GTPase Rab11. This protein regulates trafficking from the ERC and the trans-Golgi network to the plasma membrane. Such transport comprises intricate networks of proteins/lipids operating sequentially from the membrane of origin u...περισσότερα »
A novel DNA tetrahedron-hairpin probe for in situ "off-on" fluorescent imaging of intracellular telomerase activity
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00241B, Paper Qiu-Mei Feng, Meng-Jiao Zhu, Ting-Ting Zhang, Jing-Juan Xu, Hong-Yuan Chen A novel three-dimensional structure DNA probe is reported to realize in situ "off-on" imaging of intracellular telomerase activity. The probe consists of a DNA tetrahedron and a hairpin DNA on... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1SwnOrF via IFTTT
Memorial - Dr. Joseph C. Fratantoni.
*Memorial - Dr. Joseph C. Fratantoni.* Artif Cells Nanomed Biotechnol. 2016 Mar 7;:1 Authors: Alayash AI PMID: 26950293 [PubMed - as supplied by publisher] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1UPsLMQ via IFTTT
A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.
*A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response.* Cancer Cell. 2016 Mar 1; Authors: Sflomos G, Dormoy V, Metsalu T, Jeitziner R, Battista L, Scabia V, Raffoul W, Delaloye JF, Treboux A, Fiche M, Vilo J, Ayyanan A, Brisken C Abstract Seventy-five percent of breast cancers are estrogen receptor α positive (ER(+)). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenograf...περισσότερα »
Total, dietary, and supplemental calcium intake and mortality from all-causes, cardiovascular disease, and cancer: A meta-analysis of observational studies.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Total, dietary, and supplemental calcium intake and mortality from all-causes, cardiovascular disease, and cancer: A meta-analysis of observational studies.* Nutr Metab Cardiovasc Dis. 2015 Jul;25(7):623-34 Authors: Asemi Z, Saneei P, Sabihi SS, Feizi A, Esmaillzadeh A Abstract AIMS: This systematic review and meta-analysis of observational studies was conducted to summarize the evidence on the association between calcium intake and mortality. METHODS AND RESULTS: PubMed, Institute for Scientific Information (ISI)... περισσότερα »
Covered Stents versus Uncovered Stents for Unresectable Malignant Biliary Strictures: A Meta-Analysis
Aim. To summarize the covered or uncovered SEMS for treatment of unresectable malignant distal biliary obstruction, comparing the stent patency, patient survival, and incidence of adverse events between the two SEMSs. Methods. The meta-analysis search was performed independently by two of the authors, using MEDLINE, EMBASE, OVID, and Cochrane databases on all studies between 2010 and 2015. Pooled effect was calculated using either the fixed or the random effects model. Results. Statistics shows that there is no difference between SEMSs in the hazard ratio for patient survival (HR ...περισσότερα »
Data on comparison between FLEC and CLIMPAQ Methods used for fast sorption measurements of VOCs on building materials
Publication date: Available online 7 March 2016 *Source:*Data in Brief Author(s): Malak RIZK, Marie VERRIELE, Maxence MENDEZ, Nadège BLOND, Sébastien DUSANTER, Coralie SCHOEMAECKER, Patrice BLONDEAU, Stéphane LE CALVÉ, Nadine LOCOGE A test emission chamber called CLIMPAQ has been coupled to a chromatography analyzer GC to measure volatile organic compounds (VOC) concentration during a sorption experiments (Fast sorption measurements of VOCs on building materials: Part 2 – Comparison between FLEC and CLIMPAQ methods, [1]). The equations used to calculate the mass transfer coefficient... περισσότερα »
Nonlinear spectral and lifetime management in upconversion nanoparticles by controlling energy distribution.
*Nonlinear spectral and lifetime management in upconversion nanoparticles by controlling energy distribution.* Nanoscale. 2016 Mar 7; Authors: Wang Y, Deng R, Xie X, Huang L, Liu X Abstract Optical tuning of lanthanide-doped upconversion nanoparticles has attracted considerable attention over the past decade because this development allows the advance of new frontiers in energy conversion, materials science, and biological imaging. Here we present a rational approach to manipulating the spectral profile and lifetime of lanthanide emission in upconversion nanoparticles by tailorin... περισσότερα »
Beyond the Condom: Frontiers in Male Contraception.
*Beyond the Condom: Frontiers in Male Contraception.* Semin Reprod Med. 2016 Mar 4; Authors: Roth MY, Amory JK Abstract Nearly half of all pregnancies worldwide are unplanned, despite numerous contraceptive options available. No new contraceptive method has been developed for men since the invention of condom. Nevertheless, more than 25% of contraception worldwide relies on male methods. Therefore, novel effective methods of male contraception are of interest. Herein we review the physiologic basis for both male hormonal and nonhormonal methods of contraception. We review the his... περισσότερα »
LXRs and copper metabolism: New frontiers for the oxysterol receptors.
Related Articles *LXRs and copper metabolism: New frontiers for the oxysterol receptors.* Hepatology. 2016 Mar 4; Authors: Gabbi C, Bertolotti M PMID: 26946056 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1ntjQDf via IFTTT
Frontiers of Ocular Surface Regenerative Medicine.
Related Articles *Frontiers of Ocular Surface Regenerative Medicine.* Ocul Surf. 2016 Mar 2; Authors: Jester JV PMID: 26945734 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1ntjSLq via IFTTT
Usefulness of peroral endoscopic myotomy for treating achalasia in children: experience from a single center.
[image: http:--production.springer.de-OnlineReso] Related Articles *Usefulness of peroral endoscopic myotomy for treating achalasia in children: experience from a single center.* Pediatr Surg Int. 2015 Jul;31(7):633-8 Authors: Tang X, Gong W, Deng Z, Zhou J, Ren Y, Zhang Q, Chen Z, Jiang B Abstract INTRODUCTION: Achalasia is a rare esophageal motility disorder in the pediatric population. Peroral endoscopic myotomy (POEM) has been demonstrated to be effective and safe for the treatment of achalasia as a novel endoscopic technique, but data involving its utility in pediatric patie... περισσότερα »
The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia.
[image: http:--allenpress.com-system-files-image] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia.* Int Surg. 2014 Nov-Dec;99(6):846-50 Authors: Akutsu Y, Hanari N, Kono T, Uesato M, Hoshino I, Murakami K, Natsume T, Isozaki Y, Akanuma N, Toyozumi T, Suito H, Matsubara H Abstract Short gastric vessel division (SGVD) has been performed as a part of fundoplication for achalasia. However, whether or not SGVD is necessary is still unknown. Forty-six patients with achalasia who und... περισσότερα »
An unusual cause of dysphagia: "DISHphagia".
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *An unusual cause of dysphagia: "DISHphagia".* Br J Neurosurg. 2015 Apr;29(2):275-6 Authors: Bacigaluppi S, Merciadri P, Secci F, Bragazzi NL, Zona G Abstract Progressive dysphagia and dyspnoea presenting after major neck trauma can occasionally be secondary to post-traumatic inflammation and mass effect associated with a calcified osteophytic anterior longitudinal ligament, a frequent finding in diffuse idiopathic skeletal hyperostosis, though rarely enough to cause such symptoms. In these circumstances, surgical decompressi... περισσότερα »
Diagnosis and Clinical Course of Unexplained Dysphagia.
*Diagnosis and Clinical Course of Unexplained Dysphagia.* Ann Rehabil Med. 2016 Feb;40(1):95-101 Authors: Yeom J, Song YS, Lee WK, Oh BM, Han TR, Seo HG Abstract OBJECTIVE: To investigate the final diagnosis of patients with unexplained dysphagia and the clinical and laboratory findings supporting the diagnosis. METHODS: We retrospectively analyzed 143 patients with dysphagia of unclear etiology who underwent a videofluoroscopic swallowing study (VFSS). The medical records were reviewed, and patients with a previous history of diseases that could affect swallowing were categorized ... περισσότερα »
The Relation Between the Presence of Aspiration or Penetration and the Clinical Indicators of Dysphagia in Poststroke Survivors.
*The Relation Between the Presence of Aspiration or Penetration and the Clinical Indicators of Dysphagia in Poststroke Survivors.* Ann Rehabil Med. 2016 Feb;40(1):88-94 Authors: Han H, Shin G, Jun A, Park T, Ko D, Choi E, Kim Y Abstract OBJECTIVE: To examine the relation between the presence of penetration or aspiration and the occurrence of the clinical indicators of dysphagia. The presence of penetration or aspiration is closely related to the clinical indicators of dysphagia. It is essential to understand these relationships in order to implement proper diagnosis and treatment ... περισσότερα »
Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Palatopharyngoplasty with bilateral buccal mucosal graft repair to alleviate oropharyngeal stenosis.* Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1579-81 Authors: Tompkins JJ, Vaughn CA, Shaikh FA, Stocks RM, Thompson JW Abstract Oropharyngeal stenosis is rare, but known complication from tonsillectomy procedure. A 15-year-old female presented with refractory dyspnea, mild obstructive sleep apnea, and dysphagia. She underwent tonsillectomy 3 years prior. Severe cicatricial oropharyngeal scar involving soft palat... περισσότερα »
Usefulness of peroral endoscopic myotomy for treating achalasia in children: experience from a single center.
[image: http:--production.springer.de-OnlineReso] Related Articles *Usefulness of peroral endoscopic myotomy for treating achalasia in children: experience from a single center.* Pediatr Surg Int. 2015 Jul;31(7):633-8 Authors: Tang X, Gong W, Deng Z, Zhou J, Ren Y, Zhang Q, Chen Z, Jiang B Abstract INTRODUCTION: Achalasia is a rare esophageal motility disorder in the pediatric population. Peroral endoscopic myotomy (POEM) has been demonstrated to be effective and safe for the treatment of achalasia as a novel endoscopic technique, but data involving its utility in pediatric patien... περισσότερα »
The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia.
[image: http:--allenpress.com-system-files-image] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The outcome of laparoscopic surgery with and without short gastric vessel division for achalasia.* Int Surg. 2014 Nov-Dec;99(6):846-50 Authors: Akutsu Y, Hanari N, Kono T, Uesato M, Hoshino I, Murakami K, Natsume T, Isozaki Y, Akanuma N, Toyozumi T, Suito H, Matsubara H Abstract Short gastric vessel division (SGVD) has been performed as a part of fundoplication for achalasia. However, whether or not SGVD is necessary is still unknown. Forty-six patients with achalasia who unde... περισσότερα »
An unusual cause of dysphagia: "DISHphagia".
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *An unusual cause of dysphagia: "DISHphagia".* Br J Neurosurg. 2015 Apr;29(2):275-6 Authors: Bacigaluppi S, Merciadri P, Secci F, Bragazzi NL, Zona G Abstract Progressive dysphagia and dyspnoea presenting after major neck trauma can occasionally be secondary to post-traumatic inflammation and mass effect associated with a calcified osteophytic anterior longitudinal ligament, a frequent finding in diffuse idiopathic skeletal hyperostosis, though rarely enough to cause such symptoms. In these circumstances, surgical decompressio... περισσότερα »
Food Sensitization in Medically Resistant Chronic Rhinosinusitis with or without Nasal Polyposis
*Background:* Nasal polyposis is a common nasal mass with unknown etiology. It has been assumed that allergy predisposes to polyp formation. Our objective was to compare the prevalence of food sensitization in medically resistant chronic rhinosinusitis patients with or without nasal polyposis. *Methods:* One hundred and fifty-five patients who fulfilled the inclusion and exclusion criteria were incorporated into this study. The results of their total serum IgE and food-specific IgE levels were examined. *Results:* The average age was 33 years (± 13) with 96 males and 59 females. The ... περισσότερα »
Immunological Characterization of Dutch Sesame Seed-Allergic Patients
*Background:* Sesame seed is an allergen of growing importance worldwide. However, knowledge of the clinically relevant sesame allergen and its cross-reactivity with homologous allergens is limited. The aim of this study was the immunological characterization of Dutch sesame seed-allergic patients and evaluation of cross-reactivity between sesame seed, tree nut and pollen allergens using different sources of allergen extracts. *Methods:* Six patients with a medical history of sesame seed allergy were included, i.e. 5 with an anaphylactic reaction and 1 with an oral allergy syndrome ... περισσότερα »
[Author's response to article «Intrathoracic migration of a ventriculoperitoneal shunt catheter: A case report» by Y. Sánchez-Medina et al.]
*[Author's response to article «Intrathoracic migration of a ventriculoperitoneal shunt catheter: A case report» by Y. Sánchez-Medina et al.]* Neurocirugia (Astur). 2016 Mar 3; Authors: Abreu Calderón F, Carrasco Moro R, Ferreira Martins EE PMID: 26949169 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1RxX4SK via IFTTT
Dural arteriovenous fistula at the foramen magnum: Report of a case and clinical-anatomical review.
*Dural arteriovenous fistula at the foramen magnum: Report of a case and clinical-anatomical review.* Neurocirugia (Astur). 2016 Mar 3; Authors: Llácer JL, Suay G, Piquer J, Vazquez V Abstract Arterial supply and venous drainage at the foramen magnum is variable. Two main forms of clinical presentation, intracranial and spinal, can be differentiated when a dural arteriovenous fistula (DAVF) is found at this level. We describe a case of a 68-year-old patient with a progressive paraparesis, diagnosed of dural arteriovenous fistula located at the posterior lip of foramen magnum. We ... περισσότερα »
Proteomic insights into the functional basis for the response regulator DrRRA of Deinococcus radiodurans
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα
10.3109/09553002.2016.1150618<br>Liangyan Wang from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1Uam9b7 via IFTTT
Atypia of undetermined significance and follicular lesions of undetermined significance: sonographic assessment for prediction of the final diagnosis.
Related Articles *Atypia of undetermined significance and follicular lesions of undetermined significance: sonographic assessment for prediction of the final diagnosis.* J Ultrasound Med. 2015 May;34(5):767-74 Authors: Kamaya A, Lewis GH, Liu Y, Akatsu H, Kong C, Desser TS Abstract OBJECTIVES: To determine whether radiologic assessment of thyroid nodules can potentially help guide clinical management after a cytologic diagnosis of atypia of undetermined significance or a follicular lesion of undetermined significance. METHODS: We identified 41 patients with 41 thyroid nodules init... περισσότερα »
Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome.
Related Articles *Association between worse metabolic control and increased thyroid volume and nodular disease in elderly adults with metabolic syndrome.* Metab Syndr Relat Disord. 2015 Jun;13(5):221-6 Authors: Blanc E, Ponce C, Brodschi D, Nepote A, Barreto A, Schnitman M, Fossati P, Salgado P, Cejas C, Faingold C, Musso C, Brenta G Abstract BACKGROUND: Metabolic syndrome has been associated with nodular goiter. Our aim was to evaluate which metabolic parameters in elderly patients with metabolic syndrome are associated with thyroid enlargement or increased prevalence of thyroid... περισσότερα »
Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma.
Related Articles *Hypercalcemia and parathyroid hormone-related peptide expression in a dog with thyroid carcinoma and histiocytic sarcoma.* Vet Clin Pathol. 2015 Jun;44(2):249-52 Authors: Scruggs JL, Nobrega-Lee M, Fry MM, Applegate R Abstract A 9.5-year-old, male castrated Walker Hound was presented for evaluation of progressive weakness, anorexia, and weight loss. Imaging revealed multiple abdominal and thoracic masses and ascites; fine-needle aspirates of mesenteric and splenic masses confirmed malignancy, most likely histiocytic sarcoma. Laboratory analyses revealed increase... περισσότερα »
Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy.
*Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy.* Curr Pharm Des. 2016 Mar 4; Authors: Steelman LS, Fitzgerald T, Lertpiriyapong K, Cocco L, Follo MY, Martelli AM, Neri LM, Marmiroli S, Libra M, Candido S, Nicoletti F, Scalisi A, Fenga C, Drobot L, Rakus D, Gizak A, Laidler P, Dulińska-Litewka J, Basecke J, Mijatovic S, Maksimovic-Ivanic D, Montalto G, Cervello M, Milella M, Tafuri A, Demidenko Z, Abrams SL, McCubrey JA Abstract The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers i... περισσότερα »
PD-1 and PD-L1 blockade in gastrointestinal malignancies.
Related Articles *PD-1 and PD-L1 blockade in gastrointestinal malignancies.* Cancer Treat Rev. 2015 Dec;41(10):893-903 Authors: Lote H, Cafferkey C, Chau I Abstract Immunotherapy represents a major breakthrough in cancer therapy in recent years. Immune-checkpoint blockade using PD-1 and PD-L1 antibodies appears to be one of the most promising immunotherapy approaches. Immunotherapy differs from conventional cancer treatment because of its ability to produce durable responses in some patients. In this review article, we explore the available evidence and summarise current clinical... περισσότερα »
Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method.
Related Articles *Identification of potential plasma biomarkers for esophageal squamous cell carcinoma by a proteomic method.* Int J Clin Exp Pathol. 2015;8(2):1535-44 Authors: Zhao J, Fan YX, Yang Y, Liu DL, Wu K, Wen FB, Zhang CY, Zhu DY, Zhao S Abstract Among malignant tumors, the mortality rate of esophageal squamous cell carcinoma (ESCC) ranks sixth in the world. Late-stage diagnosis of ESCC increases the mortality. Therefore, more effective biomarkers for early diagnosis of ESCC are necessary. Unfortunately, appropriate biomarkers for clinical diagnosis and prognosis have ... περισσότερα »
Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett's-associated neoplasia.
Related Articles *Quantitative evaluation of in vivo vital-dye fluorescence endoscopic imaging for the detection of Barrett's-associated neoplasia.* J Biomed Opt. 2015 May;20(5):56002 Authors: Thekkek N, Lee MH, Polydorides AD, Rosen DG, Anandasabapathy S, Richards-Kortum R Abstract Current imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett's-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescen... περισσότερα »
Endoluminal cryotherapy in the management of endobronchial metastatic tumors of extrapulmonary origin.
Related Articles *Endoluminal cryotherapy in the management of endobronchial metastatic tumors of extrapulmonary origin.* J Bronchology Interv Pulmonol. 2015 Apr;22(2):135-9 Authors: Eaton D, Beeson J, Maiwand O, Anikin V Abstract BACKGROUND: Endobronchial metastases from extrapulmonary tumors are rare and often cause significant symptoms particularly when they present within the main bronchial tree. Cryotherapy has been shown to be effective in the treatment of primary malignancies of the endobronchial tree. This is the first detailed analysis of the application of cryotherapy t... περισσότερα »
Preparation of decarboxylic-functionalized weak cation exchanger and application for simultaneous separation of alkali, alkaline earth and transition metals
Publication date: 1 June 2016 *Source:*Talanta, Volume 153 Author(s): Yahui Peng, Yihui Gan, Chengxia He, Bingcheng Yang, Zhimou Guo, Xinmiao Liang A novel weak cation exchanger (WCX) with dicarboxyl groups functionalized has been developed by clicking mercaptosuccinic acid onto silica gel. The simple synthesis starts with modification of silica gel with triethoxyvinylsilane, followed by efficient coupling vinyl-bonded silica with mercaptosuccinic acid via a "thiol-ene" click reaction. The obtained WCX demonstrated good separation and high selectivity towards common metals. Simulta...περισσότερα »
Materials, Vol. 9, Pages 173: Effect of Initial Aluminum Alloy Particle Size on the Damage of Carbon Nanotubes during Ball Milling
Damage to carbon nanotubes (CNTs) during the fabrication process of CNT reinforced composites has great influence on their mechanical properties. In this study, the 2014 Al with powder sizes of 20, 9 and 5 μm was selected to study the effect of initial particle size on the damage to carbon nanotubes (CNTs) during ball milling. The result shows that for CNTs in the ball milled CNT/Al (with powder size of 20 and 9 μm) mixtures, the intensity ratio of the D band and the G band (ID/IG) first increased and then reached a plateau, mainly because most of the CNTs are embedded, to a certa... περισσότερα »
Cells, Vol. 5, Pages 11: Rab GTPases and the Autophagy Pathway: Bacterial Targets for a Suitable Biogenesis and Trafficking of Their Own Vacuoles
Autophagy is an intracellular process that comprises degradation of damaged organelles, protein aggregates and intracellular pathogens, having an important role in controlling the fate of invading microorganisms. Intracellular pathogens are internalized by professional and non-professional phagocytes, localizing in compartments called phagosomes. To degrade the internalized microorganism, the microbial phagosome matures by fusion events with early and late endosomal compartments and lysosomes, a process that is regulated by Rab GTPases. Interestingly, in order to survive and repli...περισσότερα »
JCM, Vol. 5, Pages 35: Kidney Function as a Determinant of HDL and Triglyceride Concentrations in the Australian Population
Background: Chronic kidney disease (CKD) is a potent risk factor for cardiovascular disease (CVD). CVD risk increases in a stepwise manner with increasing kidney impairment and is significantly reduced by kidney transplantation, suggesting a causal relationship. Dyslipidemia, a well recognised CVD risk factor, is highly prevalent in CKD. While dyslipidemia is a risk factor for CKD, kidney impairment can also induce a dyslipidemic state that may contribute to the excess burden of CVD in CKD. We utilised a multipronged approach to determine whether a causal relationship exists. Mate... περισσότερα »
Toxins, Vol. 8, Pages 67: Perfringolysin O Theta Toxin as a Tool to Monitor the Distribution and Inhomogeneity of Cholesterol in Cellular Membranes
Cholesterol is an essential structural component of cellular membranes in eukaryotes. Cholesterol in the exofacial leaflet of the plasma membrane is thought to form membrane nanodomains with sphingolipids and specific proteins. Additionally, cholesterol is found in the intracellular membranes of endosomes and has crucial functions in membrane trafficking. Furthermore, cellular cholesterol homeostasis and regulation of de novo synthesis rely on transport via both vesicular and non-vesicular pathways. Thus, the ability to visualize and detect intracellular cholesterol, especially in... περισσότερα »
Diversity, Vol. 8, Pages 6: Update of “Biodiversity of the Hypersaline Urmia Lake National Park (NW Iran)”
Urmia Lake, an endorheic salt lake in northwestern Iran, was registered in the Ramsar Convention on Wetlands as a wetland of international importance, also a UNESCO biosphere reserve. In this review, we have updated our last checklist in 2014 with available information on the biodiversity of the lake. from #Medicine via ola Kala on Inoreader http://ift.tt/21iDXRX Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
JMSE, Vol. 4, Pages 24: Effects of Exposure of Pink Shrimp, Farfantepenaeus duorarum, Larvae to Macondo Canyon 252 Crude Oil and the Corexit Dispersant
The release of oil into the Gulf of Mexico (GOM) during the Deepwater Horizon event coincided with the white and pink shrimp spawning season. To determine the potential impact on shrimp larvae a series of static acute (24–96 h) toxicity studies with water accommodated fractions (WAFs) of Macondo Canyon (MC) 252 crude oil, the Corexit 9500A dispersant, and chemically enhanced WAFS (CEWAFs) were conducted with nauplii, zoea, mysid, and postlarval Farfantepenaeus duorarum. Median lethal concentrations (LC50) were calculated and behavior responses (swimming, molting, light sensitivity... περισσότερα »
Arrive: A retrospective registry of Indian patients with venous thromboembolism
*Dhanesh R Kamerkar, M Joseph John, Sanjay C Desai, Liesel C Dsilva, Sadhna J Joglekar* Indian Journal of Critical Care Medicine 2016 20(3):150-158 Background and Aim: There is lack of substantial Indian data on venous thromboembolism (VTE). The aim of this study was to provide real-world information on patient characteristics, management strategies, clinical outcomes, and temporal trends in VTE. Subjects and Methods: Multicentre retrospective registry involving 549 medical records of patients with confirmed diagnosis of VTE (deep vein thrombosis [DVT] confirmed by Doppler ultras... περισσότερα »
Do not resuscitate: An expanding role for critical care response team
*Alaa M Gouda, Saad M Alqahtani* Indian Journal of Critical Care Medicine 2016 20(3):146-149 Background: Do not resuscitate (DNR) order is an important aspect of medical practice. Since the implementation of critical care response team (CCRT), frequently we have encountered with patients in the wards that should have been made DNR. Initiating DNR became an important part of CCRT activity. We were obliged to extended the role of CCRT – beyond managing seriously ill patients – in addressing the code status for patients after discussion with the managing teams. Purpose: We compare th...περισσότερα »
Scrub typhus: Experience in management of cases with pulmonary involvement in critical care unit
*Kunal Singh, Vinay Rai, Dev Singh Jangpangi, Hariom khandelwal* Indian Journal of Critical Care Medicine 2016 20(3):200-201 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1U129cn via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R4JRGS via IFTTT
Outcome and predictors of cardiopulmonary resuscitation among patients admitted in Medical Intensive Care Unit in North India
*Amit Bansal, Tirath Singh, Gautam Ahluwalia, Parminder Singh* Indian Journal of Critical Care Medicine 2016 20(3):159-163 Background: Outcome and predictors of survival after cardiopulmonary resuscitation (CPR) in Intensive Care Units (ICUs) have been extensively studied in western world, but data from developing countries is sparse. Objectives: To study the outcome and predictors of survival after CPR in a Medical ICU (MICU) of a tertiary level teaching hospital in North India. Materials and Methods: A 1-year prospective cohort study. Results: Of 105 in-MICU CPRs, forty patients... περισσότερα »
Complications and management of attempted suicide by intrapleural injection of prallethrin
*M Madhu Bashini, VP Rajavel, Vigil Rahulan* Indian Journal of Critical Care Medicine 2016 20(3):182-184 We describe the unusual presentation and management of complications of intrapleural prallethrin injection in this case report. The pathologic process is distinct from the usual toxicity secondary to effect on ionic channels of the nervous system. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1U128Fj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs ... περισσότερα »
Inadvertent migration of guidewire into Murphy’s eye of endotracheal tube during percutaneous dilatational tracheostomy
*Binita Panigrahi, Devi Prasad Samaddar, Tushar Kumar* Indian Journal of Critical Care Medicine 2016 20(3):188-190 Percutaneous dilatational tracheostomy is a commonly performed bedside procedure in the Intensive Care Unit. Although serious and fatal complications have been reported, the procedure is by and large safe to perform in experienced hands. We report here an innocuous problem encountered twice. After the guidewire insertion and dilatation, subsequent railroading became difficult owing to migration of guidewire into the Murphy's eye of the endotracheal tube (ETT). Awarene...περισσότερα »
An obstruction not to forget: Pseudo-obstruction (Ogilvie syndrome): Single center experience
*Fatih Mehmet Yazar, Burhan Hakan Kanat, Seyfi Emir, Mehmet Bugra Bozan, Yilmaz Bilgiç, Abdurrahman Sahin, Fatih Erol, Zeynep Özkan, Evrim Gül, Aykut Urfalioglu* Indian Journal of Critical Care Medicine 2016 20(3):164-168 Purpose: Colonic pseudo obstruction disease commonly seen in the elderly, immobile patient group can cause serious mortality and morbidity. Our objective in this retrospective study is to share our clinical experience by evaluating patients with Ogilvie syndrome who were followed and treated in our clinic. Methods: Eleven cases with the diagnosis of Ogilvie syndr...περισσότερα »
Hypocalcemia in acute pancreatitis revisited
*Armin Ahmed, Afzal Azim, Mohan Gurjar, Arvind Kumar Baronia* Indian Journal of Critical Care Medicine 2016 20(3):173-177 Hypocalcemia is a frequent finding in acute pancreatitis. Severe hypocalcemia can present with neurological as well as cardiovascular manifestations. Correction of hypocalcemia by parenteral calcium infusion remains a controversial topic as intracellular calcium overload is the central mechanism of acinar cell injury in pancreatitis. The current article deals with the art and science of calcium correction in pancreatitis patients. from #ORL-AlexandrosSfakianak... περισσότερα »
Advanced pressure control modes of ventilation in cardiac surgery: Scanty evidence or unexplored terrain?
*Satyen Parida, Prasanna Udupi Bidkar* Indian Journal of Critical Care Medicine 2016 20(3):169-172 Lung atelectasis resulting after cardiopulmonary bypass (CPB) can result in increased intrapulmonary shunting and consequent hypoxemia. Advanced pressure control modes of ventilation might have at least a theoretical advantage over conventional modes by assuring a minimum target tidal volume delivery at reasonable pressures, thus having potential advantages while ventilating patients with pulmonary atelectasis postcardiac surgery. However, the utility of these modes in the post-CPB s...περισσότερα »
Acute respiratory distress syndrome: Pulmonary and extrapulmonary not so similar
*Inderpaul Singh Sehgal, Sahajal Dhooria, Digambar Behera, Ritesh Agarwal* Indian Journal of Critical Care Medicine 2016 20(3):194-197 Acute respiratory distress syndrome (ARDS) is characterized by acute onset respiratory failure with bilateral pulmonary infiltrates and hypoxemia. Current evidence suggests different respiratory mechanics in pulmonary ARDS (ARDSp) and extrapulmonary ARDS (ARDSexp) with disproportionate decrease in lung compliance in the former and chest wall compliance in the latter. Herein, we report two patients of ARDS, one each with ARDSp and ARDSexp that were ...περισσότερα »
Brain lesions in eclampsia: A series of 39 cases admitted in an Intensive Care Unit
*Y Brouh, Konan Kouassi Jean, A Ouattara, Y Tétchi, Y Pete, N Koffi, C Abhé, M Kane* Indian Journal of Critical Care Medicine 2016 20(3):178-181 The aim of this study was to identify the encephalic lesions in the eclampsia occurrences. Within a period of 18 months, computed tomography (CT) of the brain was performed in all patients admitted in intensive care for eclampsia. These CTs were analyzed and intracerebral lesions were identified. Thirty-nine patients were included. We noted 10 cases of ischemic stroke, 9 cases of cerebral edema, and 3 cases of hemorrhagic stroke and suba...περισσότερα »
An unusual case of acute poisoning with paraformaldehyde, benzoic acid, and kaolin
*Abdul Hameed, Fauzia Shifaat, Mehraj Ud Din, Shoaib Budoo, Shoaib Khanday, Arshi Taj* Indian Journal of Critical Care Medicine 2016 20(3):198-199 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1U126x2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1M48wnB via IFTTT
Salient Features of Endonuclease Platforms for Therapeutic Genome Editing
*Salient Features of Endonuclease Platforms for Therapeutic Genome Editing* Molecular Therapy 24, 422 (March 2016). doi:10.1038/mt.2016.21 Authors: Michael T Certo & Richard A Morgan [image: 1TovD3X] from Cancer via ola Kala on Inoreader http://ift.tt/1QI3Dm7 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YqlqTT via IFTTT
“I Always Worry about What Might Happen Ahead”: Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda
Background. We explored healthcare provider perspectives and practices regarding safer conception counseling for HIV-affected clients. Methods. We conducted semistructured interviews with 38 providers (medical and clinical officers, nurses, peer counselors, and village health workers) delivering care to HIV-infected clients across 5 healthcare centres in Mbarara District, Uganda. Interview transcripts were analyzed using content analysis. Results. Of 38 providers, 76% were women with median age 34 years (range 24–57). First, we discuss providers' reproductive counseling practices.... περισσότερα »
Catalytic activity and thermal stability of horseradish peroxidase encapsulated in self-assembled organic nanotubes
[image: GA?id=C5AN02655E] *Analyst*, 2016, Advance Article *DOI*: 10.1039/C5AN02655E, Paper Qin Lu, Youngchan Kim, Nabil Bassim, Nisha Raman, Greg E. Collins The confined nanospace of organic nanotubes protects enzymes against thermal denaturation and preserves catalytic activity following prolonged elevated temperature exposure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry [image: 1M46DHs] from #Medicine via ola Kala on Inoreader http://ift.tt/1pcETvx via IFTTT from #Med Bl...περισσότερα »
Materials, Vol. 9, Pages 179: Compositional Design of Dielectric, Ferroelectric and Piezoelectric Properties of (K, Na)NbO3 and (Ba, Na)(Ti, Nb)O3 Based Ceramics Prepared by Different Sintering Routes
Lead free piezoelectric materials are being intensively investigated in order to substitute lead based ones, commonly used in many different applications. Among the most promising lead-free materials are those with modified NaNbO3, such as (K, Na)NbO3 (KNN) and (Ba, Na)(Ti, Nb)O3 (BTNN) families. From a ceramic processing point of view, high density single phase KNN and BTNN ceramics are very difficult to sinter due to the volatility of the alkaline elements, the narrow sintering temperature range and the anomalous grain growth. In this work, Spark Plasma Sintering (SPS) and high-... περισσότερα »
Chromatography, Vol. 3, Pages 9: The Simultaneous Determination of Silicic, Boric and Carbonic Acids in Natural Water via Ion-Exclusion Chromatography with a Charged Aerosol Detector
The simple and simultaneous determination of silicic, boric and carbonic acids was made using ion-exclusion chromatography (IEC) and a Corona™ charged aerosol detector (C-CAD). Silicic and boric acids were separated by the column packed with a weakly acidic cation-exchange resin in H+-form and ultra-pure water eluent, and the detector responses were improved by the addition of acetonitrile to eluent. Under the optimized conditions, the simultaneous determination of weak inorganic acids, except for carbonic acid, was successfully performed. When the conversion column packed with a ... περισσότερα »
Applied Sciences, Vol. 6, Pages 76: Investigation of the Machining Stability of a Milling Machine with Hybrid Guideway Systems
This study was aimed to investigate the machining stability of a horizontal milling machine with hybrid guideway systems by finite element method. To this purpose, we first created finite element model of the milling machine with the introduction of the contact stiffness defined at the sliding and rolling interfaces, respectively. Also, the motorized built-in spindle model was created and implemented in the whole machine model. Results of finite element simulations reveal that linear guides with different preloads greatly affect the dynamic responses and machining stability of the... περισσότερα »
Materials, Vol. 9, Pages 178: Effects of Ca Content on Formation and Photoluminescence Properties of CaAlSiN3:Eu2+ Phosphor by Combustion Synthesis
Effects of Ca content (in the reactant mixture) on the formation and the photoluminescence properties of CaAlSiN3:Eu2+ phosphor (CASIN) were investigated by a combustion synthesis method. Ca, Al, Si, Eu2O3, NaN3, NH4Cl and Si3N4 powders were used as the starting materials and they were mixed and pressed into a compact which was then wrapped up with an igniting agent (i.e., Mg + Fe3O4). The compact was ignited by electrical heating under a N2 pressure of ≤1.0 MPa. By keeping the molar ratios of Al and Si (including the Si powder and the Si in Si3N4 powder) both at 1.00 and that of ...περισσότερα »
Medical Sciences, Vol. 4, Pages 2: Targeting in Cancer Therapies
Drug developers recruit and combine principles, procedures and strategies from chemistry, pharmacology, nanotechnology and biotechnology, focusing on the generation of functional vehicles as nano-carriers of drugs for improved stability and enhanced intracellular delivery.[...] from #Medicine via ola Kala on Inoreader http://ift.tt/1UfJSVK via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R2IlyH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UPhWKO via IFTTT
“I Always Worry about What Might Happen Ahead”: Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda
Background. We explored healthcare provider perspectives and practices regarding safer conception counseling for HIV-affected clients. Methods. We conducted semistructured interviews with 38 providers (medical and clinical officers, nurses, peer counselors, and village health workers) delivering care to HIV-infected clients across 5 healthcare centres in Mbarara District, Uganda. Interview transcripts were analyzed using content analysis. Results. Of 38 providers, 76% were women with median age 34 years (range 24–57). First, we discuss providers' reproductive counseling practices.... περισσότερα »
Catalytic activity and thermal stability of horseradish peroxidase encapsulated in self-assembled organic nanotubes
[image: GA?id=C5AN02655E] *Analyst*, 2016, Advance Article *DOI*: 10.1039/C5AN02655E, Paper Qin Lu, Youngchan Kim, Nabil Bassim, Nisha Raman, Greg E. Collins The confined nanospace of organic nanotubes protects enzymes against thermal denaturation and preserves catalytic activity following prolonged elevated temperature exposure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry [image: 1M46DHs] from #Medicine via ola Kala on Inoreader http://ift.tt/1pcETvx via IFTTT from #Med Bl...περισσότερα »
Materials, Vol. 9, Pages 179: Compositional Design of Dielectric, Ferroelectric and Piezoelectric Properties of (K, Na)NbO3 and (Ba, Na)(Ti, Nb)O3 Based Ceramics Prepared by Different Sintering Routes
Lead free piezoelectric materials are being intensively investigated in order to substitute lead based ones, commonly used in many different applications. Among the most promising lead-free materials are those with modified NaNbO3, such as (K, Na)NbO3 (KNN) and (Ba, Na)(Ti, Nb)O3 (BTNN) families. From a ceramic processing point of view, high density single phase KNN and BTNN ceramics are very difficult to sinter due to the volatility of the alkaline elements, the narrow sintering temperature range and the anomalous grain growth. In this work, Spark Plasma Sintering (SPS) and high-... περισσότερα »
Chromatography, Vol. 3, Pages 9: The Simultaneous Determination of Silicic, Boric and Carbonic Acids in Natural Water via Ion-Exclusion Chromatography with a Charged Aerosol Detector
The simple and simultaneous determination of silicic, boric and carbonic acids was made using ion-exclusion chromatography (IEC) and a Corona™ charged aerosol detector (C-CAD). Silicic and boric acids were separated by the column packed with a weakly acidic cation-exchange resin in H+-form and ultra-pure water eluent, and the detector responses were improved by the addition of acetonitrile to eluent. Under the optimized conditions, the simultaneous determination of weak inorganic acids, except for carbonic acid, was successfully performed. When the conversion column packed with a ... περισσότερα »
Applied Sciences, Vol. 6, Pages 76: Investigation of the Machining Stability of a Milling Machine with Hybrid Guideway Systems
This study was aimed to investigate the machining stability of a horizontal milling machine with hybrid guideway systems by finite element method. To this purpose, we first created finite element model of the milling machine with the introduction of the contact stiffness defined at the sliding and rolling interfaces, respectively. Also, the motorized built-in spindle model was created and implemented in the whole machine model. Results of finite element simulations reveal that linear guides with different preloads greatly affect the dynamic responses and machining stability of the... περισσότερα »
Characterization of cadmium biosorption by Exiguobacterium sp. isolated from farmland soil near Cu-Pb-Zn mine
Abstract Bacteria have the ability to bind heavy metals on their cell wall. Biosorption is a passive and energy-independent mechanism to adsorb heavy metals. The efficiency of heavy metal biosorption can vary depending on several factors such as the growth phase of bacteria, solution pH, and existence of competitive heavy metals. In this study, *Exiguobacterium* sp. isolated from farmland soil near a mine site were used, and optimal conditions for Cd biosorption in solution were investigated. As bacterial growth progressed, Cd biosorption increased, which is attributed to changes ... περισσότερα »
Multi-objective models of waste load allocation toward a sustainable reuse of drainage water in irrigation
Abstract The present study proposes a waste load allocation (WLA) framework for a sustainable quality management of agricultural drainage water (ADW). Two multi-objective models, namely, *abatement-performance* and *abatement-equity-performance*, were developed through the integration of a water quality model (QAUL2Kw) and a genetic algorithm, by considering (1) the total waste load abatement, and (2) the inequity among waste dischargers. For successfully accomplishing modeling tasks, we developed a comprehensive overall performance measure (*E* *wla* ) reflecting possible violati... περισσότερα »
Comparing Morbidities of Bone Graft Harvesting from the Olecranon Process and the Distal Radius
[image: image]Background: The aim of this study is to compare donor-site morbidities between patients who underwent bone graft harvesting from either the olecranon process (OP) or the distal radius (DR). Methods: We evaluated 44 patients who underwent bone graft harvesting from the OP (25 cases) or the DR (19 cases) for various procedures in the ipsilateral upper extremity. Follow-up averaged 14 (OP group) and 19 months (DR group). Outcome measures included visual analog scales (VAS) for graft harvest-site pain and scar appearance, joint motion, and x-rays of the graft harvest and r...περισσότερα »
Silicone-induced Granuloma After Buttock Augmentation
[image: image]Summary: Liquid silicone is inexpensive, minimally antigenic, and likely noncarcinogenic. Its simplicity of use has made it popular as a soft-tissue filler in some parts of the world for patients seeking rapid soft-tissue augmentation of the face, breast, and buttocks. However, multiple reports describe the complications of silicone injections such as cellulitis, abscess, ulceration, and foreign body migration. We present an unusual complication of granulomatous reaction secondary to silicone injection for buttock augmentation, with a literature review of this entity a... περισσότερα »
Reconstruction of an Entire Thumb Metacarpal: A Case Report
[image: image]Summary: This case report discusses the reconstruction of an entire thumb metacarpal after a diagnosis of giant cell tumor of bone. The patient underwent excision of the entire thumb metacarpal, followed by interposition of a tricortical iliac crest bone graft and metacarpophalangeal and carpometacarpal joint arthrodeses. This option allowed salvage of the patient's native thumb with functional use as a stable post to which she can pinch and grasp objects. At 9 months postoperatively, there was no evidence of recurrence. from #Aesthetics via alexandrossfakianakis on In... περισσότερα »
Do Plastic Surgery Programs with Integrated Residencies or Subspecialty Fellowships Have Increased Academic Productivity?
[image: image]Background: The aim of this study was to evaluate the effect of different surgical training pathways on the academic performance of plastic surgical divisions. Methods: Eighty-two academic parameters for 338 plastic surgeons (PS), 1737 general surgeons (GS), and 1689 specialist surgeons (SS) from the top 55 National Institutes of Health (NIH)-funded academic departments of surgery were examined using data gathered from websites, SCOPUS, and NIH Research Portfolio Online Reporting Tools. Results: The median size of a PS division was 7 faculty members. PS faculty had low...περισσότερα »
Fossilized Nail Plate after Remote Trauma: Case Report
[image: image]Summary: The authors describe a case of retained sterile matrix in a 38-year-old Hispanic man with a history of remote trauma and soft-tissue coverage with a groin flap 13 years before presentation. The patient presented with a slowly enlarging, vertically growing dorsal thumb mass with occasional drainage. The patient had minimal functional impairment, and radiographic imaging showed a radiolucent mass projecting dorsally over the distal phalanx. Surgical exploration revealed an approximately 2 × 2 cm keratinized mass attached to a retained nail bed. The keratinized n... περισσότερα »
Keystone Island Flap: Effects of Islanding on Vascularity
[image: image]Background: Based on his clinical observations the "red dot sign" and hyperemic flare, Behan has advocated the superior vascularity of the island flap design for at least 2 decades. The aim of this study was to determine whether (1) surgical islanding of a flap alters the vascularity or blood supply of the flap and (2) these changes in blood supply explain Behan's clinical observations of "red dot sign" and hyperemic flare. Methods: Patients undergoing local island fasciocutaneous flaps or anterolateral thigh fasciocutaneous free flaps were recruited for this trial fro... περισσότερα »
Brachial Artery Aneurysm in a 7-Month-Old Infant: Case Report and Literature Review
[image: image]Summary: Congenital upper extremity aneurysms are very rare and can be challenging to diagnose and treat. Although they can present as an isolated finding, they are often associated with other systemic conditions. We present a rare case of brachial artery aneurysm in a 7-month-old boy. The patient was evaluated with ultrasound, magnetic resonance angiography, and vein mapping before surgical reconstruction. After excision of the aneurysm, the brachial artery was reconstructed with an interposition saphenous vein graft. Because of potentially associated diagnoses and th... περισσότερα »
Congenital Palatal Fistula Associated with Submucous Cleft Palate
[image: image]Background: Although cleft lip and cleft palate are among the most common congenital malformations, the presence of an isolated congenital palatal fistula along with a submucous cleft is very rare. This appears as an oval-shaped, full-thickness fenestration in the palatal midline that does not fully extend anteriorly or posteriorly, accompanied by the findings of a submucous cleft. Because of the uncommon nature of this entity, there is controversy about its etiology, diagnosis, and management. Methods: Two cases of children with congenital palatal fistulae and a submu... περισσότερα »
Efficacious Healing of Ulcerated Infantile Hemangiomas Using Topical Timolol
[image: image]Summary: Infantile hemangiomas (IHs) are the most common benign pediatric soft-tissue tumors. Ulceration—the most frequent complication of IH—tends to heal poorly and is associated with pain, bleeding, infection, and scarring. Mainstay treatment modalities include propranolol (β-blocker) and corticosteroids, whose effectiveness is countered by a need for long-term medication and risk of systemic adverse effects and ulcer recurrence. A 3-month-old infant presented to us with a large, medial thigh-ulcerated IH that progressed despite 2 prior months of dressings and topic... περισσότερα »
Metastatic Invasive Sweat Gland Adenocarcinoma of the Hand with Upper Limb Amputation/Shoulder Reconstruction: Erratum
No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1U0VmPY via IFTTT
Usefulness of Titanized Polypropylene Mesh and an Anchor System for Correction of Lower Lid Retraction
[image: image]Summary: Because of the lower eyelid's free edge anatomy, it is difficult to preserve its contours after reconstruction. We recently attempted a new operative procedure to treat 2 cases of lower lid retraction by using a titanized polypropylene mesh and an anchor system. As the lower lid skin is elevated laterally in an oblique upward direction, the location of the mesh insertion is decided and the site is marked accordingly. The mesh to be inserted is approximately 20 × 10 mm. A skin incision is rendered from the medial to the lateral side of the lower eyelid edge, an... περισσότερα »
Stein’s Double Cross-Lip Flaps Combined with Johanson’s Step Technique for Subtotal Lower Lip Reconstruction
[image: image]Background: In a previous study, a single cross-lip flap (Abbe flap) combined with Johanson's step technique for repair of defects of more than 2/3 of the lower lip was superior, in terms of aesthetic and functional outcome, compared with Bernard Webster–related techniques (cheek advancement). Herewith, a double cross-lip flap (Stein procedure) is proposed for repair of subtotal lower lip defects. A systematic review of the Stein procedure is provided. Methods: Two patients underwent a paramedian double cross-lip flap, preserving the aesthetic subunit philtrum column c... περισσότερα »
Transmaxillary Sinus Approach for Le Fort II Osteotomy
[image: image]Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer syndrome. The thin anterior walls of the MS were removed th... περισσότερα »
Combined Lymphedema and Capillary Malformation of the Lower Extremity
[image: image]Background: Primary lymphedema and capillary malformation are independent vascular malformations that can cause overgrowth of the lower extremity. We report a series of patients who had both types of malformations affecting the same leg. The condition is unique but may be confused with other types of vascular malformation overgrowth conditions (eg, Klippel–Trenaunay and Parkes Weber). Methods: Our Vascular Anomalies Center and Lymphedema Program databases were searched for patients with both capillary malformation and lymphedema. Diagnosis of lymphedema–capillary malfo... περισσότερα »
Sleep-disordered breathing children
Abstract Objective To assess the clinical significance of nasal nitric oxide (nNO) and fractional exhaled nitric oxide (FeNO) concentrations in children with sleep-disordered breathing (SDB). Methods Enrolled in this study were 30 children with SDB and 15 healthy children. The nNO and FeNO concentrations were measured noninvasively using a NIOX MINO system (Aerocrine AB, Solna, Sweden). SPSS statistics 20.0 software (IBM SPSS statistics 20.0, Armonk, NY, USA) was used to analyze the data. Results The median (25th and 75th percentiles) nNO concentration of SDB children measured i...περισσότερα »
Blood Leukocytes as Prognostic Parameter in Stroke Thrombectomy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Purpose: Despite the recent success of mechanical thrombectomy (MT) in the treatment of acute ischemic stroke, prognostic parameters and criteria for patient selection are yet uncertain. Elevated levels of white blood cells (WBCs) constitute an independent risk factor for unfavorable outcome. Here we studied the link between outcome and WBC counts obtained before and after […]
The emerging role of GATA transcription factors in development and disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Review Articles Marjolein HFM Lentjes, Hanneke EC Niessen, Yoshimitsu Akiyama, Adriaan P de Bruïne, Veerle Melotte, Manon van Engeland, Expert Reviews in Molecular Medicine, Volume 18, pp e3 Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QDN0vc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Viruses, Vol. 8, Pages 64: Recycling Endosomes and Viral Infection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Many viruses exploit specific arms of the endomembrane system. The unique composition of each arm prompts the development of remarkably specific interactions between viruses and sub-organelles. This review focuses on the viral–host interactions occurring on the endocytic recycling compartment (ERC), and mediated by its regulatory Ras-related in brain (Rab) GTPase Rab11. This protein regulates trafficking […]
Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) that are transferred between cells by extracellular vesicles (EVs) may play an important role in PM-induced cardiovascular risk. This study sought to determine if ambient […]
Overall survival after reirradiation of spinal metastases – independent validation of predictive models
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background It is unknown if survival prediction tools (SPTs) sufficiently predict survival in patients who undergo palliative reirradiation of spinal metastases. We therefore set out to clarify if SPTs can predict survival in this patient population. Methods We retrospectively analyzed spinal reirradiations performed (n = 58, 52 patients, 44 included in analysis). SPTs for patients with […]
Cardiovascular risk with DPP-4 inhibitors: latest evidence and clinical implications
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QDHmJC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Drug-induced falls in older persons: is there a role for therapeutic drug monitoring?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Falls are the leading cause of injuries among older persons. Because of ageing societies worldwide, falls are expected to become a prominent public health problem. The usage of several types of drugs has been associated with an increased fall and fracture risk. In order to reduce future falls, preventative measures are needed. Therapeutic drug […]
Use of doripenem and risk of seizure and renal impairment in US hospitalized patients: a retrospective cohort study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives: A large retrospective database study was conducted to assess the incidence rate of treatment-emergent renal impairment/failure, seizure, and hemolytic anemia in doripenem and imipenem intravenous (IV)-exposed patients treated for complicated urinary tract infection (cUTI) and complicated intra-abdominal infection (cIAI) in US hospitals. Methods: Using the Premier Perspective™ Database (PPD), which maintains hospital discharge records […]
Cells, Vol. 5, Pages 11: Rab GTPases and the Autophagy Pathway: Bacterial Targets for a Suitable Biogenesis and Trafficking of Their Own Vacuoles
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autophagy is an intracellular process that comprises degradation of damaged organelles, protein aggregates and intracellular pathogens, having an important role in controlling the fate of invading microorganisms. Intracellular pathogens are internalized by professional and non-professional phagocytes, localizing in compartments called phagosomes. To degrade the internalized microorganism, the microbial phagosome matures by fusion events with early […]
Cells, Vol. 5, Pages 10: Hypoxia Induced NF-κB
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the […]
Rapid maxillary expansion versus middle ear tube placement:Comparison of hearing improvements in children with resistance otitis media with effusion
The Angle Orthodontist, Ahead of Print. from #Dental via xlomafota13 on Inoreader http://ift.tt/1ntc8sS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Incremental diagnostic utility of gastric distension FDG PET/CT
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
European Journal of Nuclear Medicine & Molecular Imaging from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/21V7NBv via IFTTT
Systematic review with meta-analysis: diagnostic overlap of microscopic colitis and functional bowel disorders
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Alimentary Pharmacology and Therapeutics from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QzGmop via IFTTT
Outcome of chemotherapy in advanced synovial sarcoma patients: Review of 15 clinical trials from the European Organi sation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: May 2016 Source:European Journal of Cancer, Volume 58 Author(s): Myrella Vlenterie, Saskia Litière, Elisa Rizzo, Sandrine Marréaud, Ian Judson, Hans Gelderblom, Axel Le Cesne, Eva Wardelmann, Christina Messiou, Alessandro Gronchi, Winette TA. van der Graaf IntroductionPrevious studies in metastatic soft tissue sarcomas (STS) showed that synovial sarcomas tend to have better survival rates […]
Mucinous Epithelial Tumors Arising from Ovarian Mature Teratomas: A Tissue Genotyping Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Aims The association of ovarian mucinous tumors with teratomas is well documented at tissue level, suggesting that some ovarian mucinous tumors arise from teratomas. Teratomas, being of germ cell origin, are genetically distinct from somatic cells, therefore providing a molecular basis for DNA genotyping to separate teratoma-derived mucinous tumors from metastatic ones. We assessed […]
Early safety and efficacy of fingolimod treatment in Denmark
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background Initiation of fingolimod treatment is associated with a transient decrease of heart rate, and atrioventricular (AV) conduction block may occur. Objective To evaluate the therapeutic effect and safety of fingolimod treatment in MS patients in Denmark with focus on cardiac and pulmonary side effects at treatment onset. Materials & methods We analysed data from […]
Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Evidence has demonstrated that hypoxia may have a central pathogenic mechanism in the development of diabetic nephropathy (DN). Epithelial-to-mesenchymal transition (EMT) of mature tubular epithelial cells in kidney is a contributor to the renal accumulation of matrix protein in DN and is highly associated with the progression of tubulointerstitial fibrosis. Zinc (Zn) has anti-fibrosis […]
Light up the bioluminescence with coelenterazine: strategies and applications
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C5PP00456J, Perspective Tianyu Jiang, Lupei Du, Minyong Li The bioluminescence-based techniques, such as bioluminescent imaging, BRET and dual-luciferase reporter assay systems, have been widely used in examining a myriad of biological processes. Coelenterazine (CTZ), as luciferin or light-producing… The content of this RSS Feed (c) The Royal Society […]
Human papillomavirus 16 E2 interacts with neuregulin receptor degradation protein 1 affecting ErbB-3 expression in vitro and in clinical samples of cervical lesions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: May 2016 Source:European Journal of Cancer, Volume 58 Author(s): Francesca Paolini, Gianfranca Curzio, Elisa Melucci, Irene Terrenato, Barbara Antoniani, Mariantonia Carosi, Marcella Mottolese, Patrizia Vici, Luciano Mariani, Aldo Venuti The ErbB tyrosine kinase receptors play a key role in regulating many cellular functions and human papillomaviruses (HPVs) may interact with transductional pathway of […]
Outcome of chemotherapy in advanced synovial sarcoma patients: Review of 15 clinical trials from the European Organi sation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group; setting a new landmark for studies in this entity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: May 2016 Source:European Journal of Cancer, Volume 58 Author(s): Myrella Vlenterie, Saskia Litière, Elisa Rizzo, Sandrine Marréaud, Ian Judson, Hans Gelderblom, Axel Le Cesne, Eva Wardelmann, Christina Messiou, Alessandro Gronchi, Winette TA. van der Graaf IntroductionPrevious studies in metastatic soft tissue sarcomas (STS) showed that synovial sarcomas tend to have better survival rates […]
Impact of dialysis practice patterns on outcomes in acute kidney injury in Intensive Care Unit
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Pralay Shankar Ghosh, Shakti Bedanta Mishra, Afzal Azim Indian Journal of Critical Care Medicine 2016 20(3):198-198 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/21iKTi5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fatal right ventricular failure and pulmonary hypertension after protamine administration during cardiac transplantation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Bibek S Pannu, Devang K Sanghavi, Pramod K Guru, Dereddi Raja Reddy, Vivek N Iyer Indian Journal of Critical Care Medicine 2016 20(3):185-187 Protamine sulfate is the only Food and Drug administration approved medication for reversal of intraoperative heparin-induced anticoagulation during cardiac and vascular surgeries. One of the rare side effects of protamine sulfate is […]
Nurse’s perceptions of physiotherapists in critical care team: Report of a qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Pranati Gupte, Narasimman Swaminathan Indian Journal of Critical Care Medicine 2016 20(3):141-145 Background: Interprofessional relationship plays a major role in effective patient care. Specialized units such as critical care require multidisciplinary care where perception about every members role may affect the delivery of patient care. The objective of this study was to find out nurses’ […]
CSTMP Exerts Anti-Inflammatory Effects on LPS-Induced Human Renal Proximal Tubular Epithelial Cells by Inhibiting TLR4-Mediated NF-κB Pathways
Abstract (E)-2-(2-chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP), a novel stilbene derivative, have been shown to have cytoprotective effects against H2O2-induced oxidative stress in human endothelial cells. However, little is known about its anti-inflammatory effects in lupus nephritis (LN). In the present study, we investigated the anti-inflammatory effects of CSTMP on lipopolysaccharide (LPS)-induced human renal proximal tubular epithelial cells (hRPTECs) and elucidated its molecular mechanisms. CSTMP significantly attenuated the cytotoxicity and suppressed the release of proinf...περισσότερα »
Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression
Abstract High-mobility group box 1 (HMGB1) plays a key role in the development of acute lung injury (ALI). Propofol, a general anesthetic with anti-inflammatory properties, has been suggested to be able to modulate lipopolysaccharide (LPS)-induced ALI. In this study, we investigated the effects of propofol on the expression of HMGB1 in a rat model of LPS-induced ALI. Rats underwent intraperitoneal injection of LPS to mimic sepsis-induced ALI. Propofol bolus (1, 5, or 10 mg/kg) was infused continuously 30 min after LPS administration, followed by infusion at 5 mg/(kg · h) through t... περισσότερα »
Incidence of Opportunistic Infections and the impact of Antiretroviral Therapy among HIV-Infected Adults in Low and Middle Income Countries: a Systematic Review and Meta-analysis
This meta-analysis provides strong evidence that antiretroviral therapy has led to a major reduction in the incidence of key opportunistic infections in low and middle-income countries. ART was estimated to have averted about a million cases of opportunistic infections in 2013. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/21iJJ6c via IFTTT
Reply from the authors
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1pvbcG5 via IFTTT
Prophylactic Antibiotics in mechanically ventilated patients: does it apply to burn patients?
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1UPdqM8 via IFTTT
Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1TH6O3x via IFTTT
Pharmaceuticals in the environment
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1W5sRyd via IFTTT
Effect of SiO 2 nanoparticles on the removal of natural organic matter (NOM) by coagulation
Abstract In order to evaluate effect of engineered nanoparticles on the removal of natural organic matter (NOM), ENPs water sample (WATERNP), and common water sample (WATERCOMMON) were prepared by mixing the SiO2 nanoparticles (SiO2 NPs, 50 nm) and common SiO2 particles (2 μm) with water from Xiaoqing River. The removal variation, NOM fractionation, flocs properties, and IR spectra were investigated after polyaluminum chloride (PAC) coagulation. The results revealed that although the removal efficiencies of turbidity and NOM from WATERNP were moderately lower than those from WATERC... περισσότερα »
Topographical and functional anatomy of trapezius muscle innervation by spinal accessory nerve and C2 to C4 nerves of cervical plexus
Abstract The aim of this study was to determine the existence and the frequency of communicating branches between the spinal accessory nerve (SAN) and the C2, C3 and C4 roots of the cervical plexus. The present study also aimed to elucidate whether these branches contain motor fibers or not. Dissection of the cervical region was performed on twelve adult cadavers. A powered operating microscope was necessary to dissect the SAN and its branches and also to dissect C2, C3 and C4 nerve branches. In a second step, data from 13 patients who underwent 25 modified neck dissections under t...περισσότερα »
Mucinous Epithelial Tumors Arising from Ovarian Mature Teratomas: A Tissue Genotyping Study
Abstract Aims The association of ovarian mucinous tumors with teratomas is well documented at tissue level, suggesting that some ovarian mucinous tumors arise from teratomas. Teratomas, being of germ cell origin, are genetically distinct from somatic cells, therefore providing a molecular basis for DNA genotyping to separate teratoma-derived mucinous tumors from metastatic ones. We assessed the diagnostic utility of DNA genotyping in ovarian mucinous tumors. Methods and Results: Nine cases of ovarian mucinous borderline tumors and three mucinous carcinomas associated with teratoma... περισσότερα »
Calculating regional tissue volume for Hyperthermic isolated limb perfusion: Four methods compared
Publication date: Available online 8 March 2016 *Source:*European Journal of Surgical Oncology (EJSO) Author(s): Diego Cecchin, Anna Negri, Anna Chiara Frigo, Franco Bui, Pietro Zucchetta, Valentina Bodanza, Michele Gregianin, Luca Giovanni Campana, Carlo Riccardo Rossi, Marco Rastrelli IntroductionHyperthermic isolated limb perfusion (HILP) can be performed as an alternative to amputation for soft tissue sarcomas and melanomas of the extremities. Melphalan and tumor necrosis factor-alpha are used at a dosage that depends on the volume of the limb. Regional tissue volume is traditio...περισσότερα »
What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases?
Abstract A volumetric analysis of pre- and post-radiosurgery (PreSRS and PostSRS) edema in patients with cerebral metastases was performed to determine factors of a predictive model assessing the risk of developing increased edema relatively early after SRS. One-hundred-fourteen metastases in 55 patients were analyzed. Selection for this analysis required an MRI ≤ 30 days before SRS and an MRI ≤ 100 days after SRS. Tumor volumes were calculated on PreSRS, SRS, and PostSRS T1-weighted postgadolinium images while edema volumes were calculating using PreSRS and PostSRS fluid-attenuat... περισσότερα »
A Perspective on the State of Genome Editing
*A Perspective on the State of Genome Editing* Molecular Therapy 24, 412 (March 2016). doi:10.1038/mt.2016.28 Author: Dana Carroll from Cancer via ola Kala on Inoreader http://ift.tt/1QI3DT1 via IFTTT
Acute renal allograft rejection after immune checkpoint inhibitor therapy for metastatic melanoma
This case of acute renal allograft rejection following treatment with immune checkpoint inhibitor therapy for metastatic melanoma highlights specific concerns regarding use of anti-PD-1 agents such as nivolumab. Given rates of adverse events are generally much lower with anti-PD-1 antibodies compared with anti-CTLA-4 antibodies, there is potential for error in the generalisation of perceived safety. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1TnWkFY via IFTTT
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
*Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome* Molecular Therapy 24, 636 (March 2016). doi:10.1038/mt.2015.218 Authors: Maximilian Müller, Ciaran M Lee, Giedrius Gasiunas, Timothy H Davis, Thomas J Cradick, Virginijus Siksnys, Gang Bao, Toni Cathomen & Claudio Mussolino from Cancer via ola Kala on Inoreader http://ift.tt/1TovFbT via IFTTT
Safety of the PD-1 antibody Pembrolizumab in Patients with High Grade Adverse Events under Ipilimumab Treatment
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/21ij898 via IFTTT
CRISPR/Cas9 Flexes Its Muscles: In Vivo Somatic Gene Editing for Muscular Dystrophy
*CRISPR/Cas9 Flexes Its Muscles: In Vivo Somatic Gene Editing for Muscular Dystrophy* Molecular Therapy 24, 414 (March 2016). doi:10.1038/mt.2016.29 Authors: Thierry VandenDriessche & Marinee K Chuah from Cancer via ola Kala on Inoreader http://ift.tt/1QI3DCD via IFTTT
Insertion of central venous catheters (CVCs): any changes in the past ten years?
from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/21Uudmv via IFTTT
CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy
*CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy* Molecular Therapy 24, 527 (March 2016). doi:10.1038/mt.2015.200 Authors: Charis L Himeda, Takako I Jones & Peter L Jones from Cancer via ola Kala on Inoreader http://ift.tt/1TovDAM via IFTTT
Minimal residual disease-based effect and long-term outcome of first-line dasatinib combined with chemotherapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia
First-line incorporation of dasatinib into chemotherapy is effective for achieving a good quality molecular response and durable disease-free survival in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. Quantitatively monitoring minimal residual disease kinetics is important to identify a subgroup of patients at high risk of treatment failure. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/21ij6y7 via IFTTT
A CRISPR Approach for Reactivating Latent HIV-1
*A CRISPR Approach for Reactivating Latent HIV-1* Molecular Therapy 24, 416 (March 2016). doi:10.1038/mt.2016.30 Authors: Angel Lin & Zachary Klase from Cancer via ola Kala on Inoreader http://ift.tt/1QI3Fu1 via IFTTT
Ocular Toxicities of MEK inhibitors and other targeted therapies
Novel agents that target different cellular pathways have been related to a wide spectrum of ophthalmologic adverse events. We discuss ophthalmologic toxicities associated with molecular targeted therapies, with particular focus on MEK retinopathy, including its nomenclature, incidence, symptoms and management. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/21UuaHt via IFTTT
CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice
*CRISPR-mediated Genome Editing Restores Dystrophin Expression and Function in mdx Mice* Molecular Therapy 24, 564 (March 2016). doi:10.1038/mt.2015.192 Authors: Li Xu, Ki Ho Park, Lixia Zhao, Jing Xu, Mona El Refaey, Yandi Gao, Hua Zhu, Jianjie Ma & Renzhi Han from Cancer via ola Kala on Inoreader http://ift.tt/1TovDkt via IFTTT
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51
Background Endoplasmic reticulum (ER) stress results from protein misfolding imbalance and has been postulated as a therapeutic strategy. ER stress activates the unfolded protein response which leads to a complex cellular response, including the upregulation of aberrant protein degradation in the ER, with the goal of resolving that stress. O6-methylguanine DNA methyltransferase (MGMT), *N*-methylpurine DNA glycosylase (MPG), and Rad51 are DNA damage repair proteins that mediate resistance to temozolomide in glioblastoma. In this work we sought to evaluate whether ER stress-induci...περισσότερα »
Calculating regional tissue volume for Hyperthermic isolated limb perfusion: Four methods compared
Publication date: Available online 8 March 2016 *Source:*European Journal of Surgical Oncology (EJSO) Author(s): Diego Cecchin, Anna Negri, Anna Chiara Frigo, Franco Bui, Pietro Zucchetta, Valentina Bodanza, Michele Gregianin, Luca Giovanni Campana, Carlo Riccardo Rossi, Marco Rastrelli IntroductionHyperthermic isolated limb perfusion (HILP) can be performed as an alternative to amputation for soft tissue sarcomas and melanomas of the extremities. Melphalan and tumor necrosis factor-alpha are used at a dosage that depends on the volume of the limb. Regional tissue volume is traditio...περισσότερα »
What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases?
Abstract A volumetric analysis of pre- and post-radiosurgery (PreSRS and PostSRS) edema in patients with cerebral metastases was performed to determine factors of a predictive model assessing the risk of developing increased edema relatively early after SRS. One-hundred-fourteen metastases in 55 patients were analyzed. Selection for this analysis required an MRI ≤ 30 days before SRS and an MRI ≤ 100 days after SRS. Tumor volumes were calculated on PreSRS, SRS, and PostSRS T1-weighted postgadolinium images while edema volumes were calculating using PreSRS and PostSRS fluid-attenuat... περισσότερα »
Calculating regional tissue volume for Hyperthermic isolated limb perfusion: Four methods compared
Publication date: Available online 8 March 2016 *Source:*European Journal of Surgical Oncology (EJSO) Author(s): Diego Cecchin, Anna Negri, Anna Chiara Frigo, Franco Bui, Pietro Zucchetta, Valentina Bodanza, Michele Gregianin, Luca Giovanni Campana, Carlo Riccardo Rossi, Marco Rastrelli IntroductionHyperthermic isolated limb perfusion (HILP) can be performed as an alternative to amputation for soft tissue sarcomas and melanomas of the extremities. Melphalan and tumor necrosis factor-alpha are used at a dosage that depends on the volume of the limb. Regional tissue volume is traditio...περισσότερα »
What predicts early volumetric edema increase following stereotactic radiosurgery for brain metastases?
Abstract A volumetric analysis of pre- and post-radiosurgery (PreSRS and PostSRS) edema in patients with cerebral metastases was performed to determine factors of a predictive model assessing the risk of developing increased edema relatively early after SRS. One-hundred-fourteen metastases in 55 patients were analyzed. Selection for this analysis required an MRI ≤ 30 days before SRS and an MRI ≤ 100 days after SRS. Tumor volumes were calculated on PreSRS, SRS, and PostSRS T1-weighted postgadolinium images while edema volumes were calculating using PreSRS and PostSRS fluid-attenuat... περισσότερα »
Religions, Vol. 7, Pages 26: Effect of the “Spiritual Support” Intervention on Spirituality and the Clinical Parameters of Women Who Have Undergone Mastectomy: A Pilot Study
This study aimed to evaluate the effect of the spiritual support intervention on spirituality and the clinical parameters of women who have undergone mastectomy. This is a pilot study of a randomized clinical trial. The spiritual support intervention was composed of meditation, guided imagery, music, and respiratory relaxation. The outcomes were: spirituality, blood pressure, heart rate, and oxygen saturation. A total of 27 patients were recruited for the study (intervention group, n = 13; control group, n = 14) (Clinical Trials: NCT 01866670/CAE: 00896312.0.0000.5393). The interv... περισσότερα »
Remote Sensing, Vol. 8, Pages 217: Forest Disturbances and Regrowth Assessment Using ALOS PALSAR Data from 2007 to 2010 in Vietnam, Cambodia and Lao PDR
This paper aims to develop a new methodology for monitoring forest disturbances and regrowth using ALOS PALSAR data in tropical regions. In the study, forest disturbances and regrowth were assessed between 2007 and 2010 in Vietnam, Cambodia and Lao People's Democratic Republic. The deforestation rate in Vietnam has been among the highest in the tropics in the last few decades, and those in Cambodia and Lao are increasing rapidly. L-band ALOS PALSAR mosaic data were used for the detection of forest disturbances and regrowth, because L-band SAR intensities are sensitive to forest ab...περισσότερα »
IJMS, Vol. 17, Pages 348: Molecular Cloning and Expression Analysis of IgD in Nile Tilapia (Oreochromis niloticus) in Response to Streptococcus agalactiae Stimulus
[image: ag] IgD is considered to be a recently-evolved Ig and a puzzling molecule, being previously found in all vertebrate taxa, except for birds. Although IgD likely plays an important role in vertebrate immune responses, the function of IgD in Nile tilapia (Oreochromis niloticus) is virtually unknown. In the present study, a membrane form of IgD (mIgD) heavy chains were cloned from the GIFT strain of Nile tilapia (designated On-mIgD). The On-mIgD heavy chain's cDNA is composed of 3347 bp with a 31 bp of 5′-UTR, 3015 bp open reading frame (ORF) and 301 bp 3′-UTR, encoding a polyp... περισσότερα »
Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness.
[image: wk-health-logo.gif] Objectives: Molecular mechanisms linking autonomic dysfunction with poorer clinical outcomes in critical illness remain unclear. We hypothesized that baroreflex dysfunction alone is sufficient to cause cardiac impairment through neurohormonal activation of (nicotinamide adenine dinucleotide phosphate oxidase dependent) oxidative stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regulator of cardiac function. Design: Laboratory/clinical investigations. Setting: University laboratory/medical centers. Subjects: ... περισσότερα »
“I Always Worry about What Might Happen Ahead”: Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda
Background. We explored healthcare provider perspectives and practices regarding safer conception counseling for HIV-affected clients. Methods. We conducted semistructured interviews with 38 providers (medical and clinical officers, nurses, peer counselors, and village health workers) delivering care to HIV-infected clients across 5 healthcare centres in Mbarara District, Uganda. Interview transcripts were analyzed using content analysis. Results. Of 38 providers, 76% were women with median age 34 years (range 24–57). First, we discuss providers' reproductive counseling practices.... περισσότερα »
Catalytic activity and thermal stability of horseradish peroxidase encapsulated in self-assembled organic nanotubes
[image: GA?id=C5AN02655E] *Analyst*, 2016, Advance Article *DOI*: 10.1039/C5AN02655E, Paper Qin Lu, Youngchan Kim, Nabil Bassim, Nisha Raman, Greg E. Collins The confined nanospace of organic nanotubes protects enzymes against thermal denaturation and preserves catalytic activity following prolonged elevated temperature exposure. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1pcETvx via IFTTT
Materials, Vol. 9, Pages 179: Compositional Design of Dielectric, Ferroelectric and Piezoelectric Properties of (K, Na)NbO3 and (Ba, Na)(Ti, Nb)O3 Based Ceramics Prepared by Different Sintering Routes
Lead free piezoelectric materials are being intensively investigated in order to substitute lead based ones, commonly used in many different applications. Among the most promising lead-free materials are those with modified NaNbO3, such as (K, Na)NbO3 (KNN) and (Ba, Na)(Ti, Nb)O3 (BTNN) families. From a ceramic processing point of view, high density single phase KNN and BTNN ceramics are very difficult to sinter due to the volatility of the alkaline elements, the narrow sintering temperature range and the anomalous grain growth. In this work, Spark Plasma Sintering (SPS) and high-... περισσότερα »
Chromatography, Vol. 3, Pages 9: The Simultaneous Determination of Silicic, Boric and Carbonic Acids in Natural Water via Ion-Exclusion Chromatography with a Charged Aerosol Detector
The simple and simultaneous determination of silicic, boric and carbonic acids was made using ion-exclusion chromatography (IEC) and a Corona™ charged aerosol detector (C-CAD). Silicic and boric acids were separated by the column packed with a weakly acidic cation-exchange resin in H+-form and ultra-pure water eluent, and the detector responses were improved by the addition of acetonitrile to eluent. Under the optimized conditions, the simultaneous determination of weak inorganic acids, except for carbonic acid, was successfully performed. When the conversion column packed with a ... περισσότερα »
Applied Sciences, Vol. 6, Pages 76: Investigation of the Machining Stability of a Milling Machine with Hybrid Guideway Systems
This study was aimed to investigate the machining stability of a horizontal milling machine with hybrid guideway systems by finite element method. To this purpose, we first created finite element model of the milling machine with the introduction of the contact stiffness defined at the sliding and rolling interfaces, respectively. Also, the motorized built-in spindle model was created and implemented in the whole machine model. Results of finite element simulations reveal that linear guides with different preloads greatly affect the dynamic responses and machining stability of the... περισσότερα »
Materials, Vol. 9, Pages 178: Effects of Ca Content on Formation and Photoluminescence Properties of CaAlSiN3:Eu2+ Phosphor by Combustion Synthesis
Effects of Ca content (in the reactant mixture) on the formation and the photoluminescence properties of CaAlSiN3:Eu2+ phosphor (CASIN) were investigated by a combustion synthesis method. Ca, Al, Si, Eu2O3, NaN3, NH4Cl and Si3N4 powders were used as the starting materials and they were mixed and pressed into a compact which was then wrapped up with an igniting agent (i.e., Mg + Fe3O4). The compact was ignited by electrical heating under a N2 pressure of ≤1.0 MPa. By keeping the molar ratios of Al and Si (including the Si powder and the Si in Si3N4 powder) both at 1.00 and that of ...περισσότερα »
Medical Sciences, Vol. 4, Pages 2: Targeting in Cancer Therapies
Drug developers recruit and combine principles, procedures and strategies from chemistry, pharmacology, nanotechnology and biotechnology, focusing on the generation of functional vehicles as nano-carriers of drugs for improved stability and enhanced intracellular delivery.[...] from #Medicine via ola Kala on Inoreader http://ift.tt/1UfJSVK via IFTTT
Sustainability, Vol. 8, Pages 249: Subsurface Drainage to Enable the Cultivation of Winter Crops in Consolidated Paddy Fields in Northern Iran
Subsurface drainage is a prerequisite to grow winter crops in the consolidated paddy fields in Northern Iran. A four-year study (2011–2015) was conducted to quantify the effects of subsurface drainage on the saturated hydraulic conductivity, water table, drain discharge and winter crop yields. Subsurface drainage systems with two drain depths of 0.65 and 0.90 m and two drain spacings of 15 and 30 m were installed at the consolidated paddy fields of Sari Agricultural Sciences and Natural Resources University, Iran. During four successive winter seasons, the water table depth and dr... περισσότερα »
Marine Drugs, Vol. 14, Pages 48: Antimicrobials from Cnidarians. A New Perspective for Anti-Infective Therapy?
The ability of microbes to counter the scientific and therapeutic advancements achieved during the second half of the twentieth century to provide effective disease treatments is currently a significant challenge for researchers in biology and medicine. The discovery of antibiotics, and the subsequent development of synthetic antimicrobial compounds, altered our therapeutic approach towards infectious diseases, and improved the quality and length of life for humans and other organisms. The current alarming rise in cases of antibiotic-resistance has forced biomedical researchers to... περισσότερα »
Forests, Vol. 7, Pages 61: Estimation of Tree Stem Attributes Using Terrestrial Photogrammetry with a Camera Rig
We propose a novel photogrammetric method for field plot inventory, designed for simplicity and time efficiency on-site. A prototype multi-camera rig was used to acquire images from field plot centers in multiple directions. The acquisition time on-site was less than two minutes. From each view, a point cloud was generated using a novel, rig-based matching of detected SIFT keypoints. Stems were detected in the merged point cloud, and their positions and diameters were estimated. The method was evaluated on 25 hemi-boreal forest plots of a 10-m radius. Due to difficult lighting con... περισσότερα »
Econometrics, Vol. 4, Pages 12: Evolutionary Sequential Monte Carlo Samplers for Change-Point Models
Sequential Monte Carlo (SMC) methods are widely used for non-linear filtering purposes. However, the SMC scope encompasses wider applications such as estimating static model parameters so much that it is becoming a serious alternative to Markov-Chain Monte-Carlo (MCMC) methods. Not only do SMC algorithms draw posterior distributions of static or dynamic parameters but additionally they provide an estimate of the marginal likelihood. The tempered and time (TNT) algorithm, developed in this paper, combines (off-line) tempered SMC inference with on-line SMC inference for drawing real...περισσότερα »
Sustainability, Vol. 8, Pages 246: A Novel Environmental Performance Evaluation of Thailand’s Food Industry Using Structural Equation Modeling and Fuzzy Analytic Hierarchy Techniques
Currently, the environment and sustainability are important topics for every industry. The food industry is particularly complicated in this regard because of the dynamic and complex character of food products and their production. This study uses structural equation modeling (SEM) and a fuzzy analytic hierarchy process (FAHP) to investigate which factors are suitable for evaluating the environmental performance of Thailand's food industry. A first-stage questionnaire survey was conducted with 178 managers in the food industry that obtained a certificate from the Department of Ind... περισσότερα »
Water, Vol. 8, Pages 90: Precipitation Intensity Effects on Groundwater Recharge in the Southwestern United States
Episodic recharge as a result of infrequent, high intensity precipitation events comprises the bulk of groundwater recharge in arid environments. Climate change and shifts in precipitation intensity will affect groundwater continuity, thus altering groundwater recharge. This study aims to identify changes in the ratio of groundwater recharge and precipitation, the R:P ratio, in the arid southwestern United States to characterize observed changes in groundwater recharge attributed to variations in precipitation intensity. Our precipitation metric, precipitation intensity magnificat... περισσότερα »
Cells, Vol. 5, Pages 10: Hypoxia Induced NF-κB
As Nuclear Factor-κB (NF-κB) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-κB becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-κB. In addition, we will discuss the role of NF-κB in the control of the cellular response to hypoxia. from #Medicine via ola Kala on Inoreade... περισσότερα »
Entropy, Vol. 18, Pages 87: Entropy Production in the Theory of Heat Conduction in Solids
The evolution of the entropy production in solids due to heat transfer is usually associated with the Prigogine's minimum entropy production principle. In this paper, we propose a critical review of the results of Prigogine and some comments on the succeeding literature. We suggest a characterization of the evolution of the entropy production of the system through the generalized Fourier modes, showing that they are the only states with a time independent entropy production. The variational approach and a Lyapunov functional of the temperature, monotonically decreasing with time, ... περισσότερα »
Issue Information - Editorial Board
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Buchtipps
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 140-140 DOI: 10.1055/s-0042-101377 Für Sie gelesen: In dieser Rubrik stellen wir Ihnen Neuerscheinungen aus Ihrem Fachbereich vor. In dieser Ausgabe: […] © Georg Thieme Verlag Stuttgart · New York Article in Thieme eJournals: Table of contents | Abstract | Full text from Anaesthesiology via xlomafota13 on Inoreader http://ift.tt/1LO2aOf via […]
Investigating Relationships Between Health-Related Problems and Online Health Information Seeking.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Online health information seeking (OHIS) functions as a coping strategy to relieve health-related stress and problems. When people rate their health as poor or felt concern about their health, they frequently visit the Internet to seek health-related information in order to understand their symptoms and treatments. Regarding this role of OHIS, it is important to […]
Forum der Industrie
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Anästhesiol Intensivmed Notfallmed Schmerzther 2016; 51: 142-142 DOI: 10.1055/s-0042-100646 Im Forum der Industrie lesen Sie über Marktneuheiten von A wie Analgetika bis Z wie zentraler Venenkatheter. Sie erhalten nützliche Informationen über Wirkungsweise, Anwendung und technische Ausstattung von Produkten – nach Angaben der Hersteller.In dieser Ausgabe: […] © Georg Thieme Verlag Stuttgart · New York Article […]
Nurses’ Use of a Web-Based National Guide for Child Health Care.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Rikshandboken i Barnhalsovard is a Swedish Web-based guide for child healthcare, providing quality-ensured guidelines and support contributing to equality in child healthcare among all children. In 2015, a new child healthcare program was implemented and made available in this Web-based guide. The aim of this study was to investigate how child healthcare nurses use Rikshandboken […]
Interference with daily activities and major adverse events during esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter: a systematic review of randomized controlled trials
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary For three decades, ambulatory 24-hour intranasal pH monitoring has been the established gold standard for detecting acid reflux in patients with refractory gastroesophageal reflux disease. However, device-associated adverse events and unpleasant experiences, reported by patients during pH monitoring have led to the invention of more convenient pH monitors such as Bravo wireless capsule. To […]
Mitteilungen der Verbände
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Verhaltenstherapie 2016;26:71-74 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/21V4z0X via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1U0Yds3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SwlrFp via IFTTT from #Med Blogs by Alexandros […]
Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Summary The rate of lymph-node (LN) metastasis in early adenocarcinoma (EAC) of the esophagus with mid to deep submucosal invasion (pT1b sm2/3) has not yet been precisely defined. The aim of the this study was to evaluate the rate of LN metastasis in pT1b sm2/3 EAC depending on macroscopic and histological risk patterns to find […]
Subjective Well-Being Among HIV-Positive South Africans: The Influence of Resilience and Social Capital
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Living with HIV in a context of adversity may impact on a person’s sense of well-being. Little is however known about factors associated with subjective well-being (SWB) among persons living with HIV and AIDS (PLWHAs) in sub-Saharan Africa. This study examined the relationship between SWB, resilience and social capital. Participants were 263 HIV-positive, black […]
Retroauricular Endoscope-Assisted Approach to the Neck: Early Experience in Latin America
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Int Arch Otorhinolaryngol DOI: 10.1055/s-0036-1578807 Introduction There has been a significant increase in concern towards improving aesthetic and functional outcomes without compromising the oncologic effectiveness in head and neck surgery. In this subset, endoscope-assisted and robotic procedures allowed the development of new approaches to the neck, including the retroauricular access, which is now routinely used, especially […]
Curcumin Reduces the Noise-Exposed Cochlear Fibroblasts Apoptosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Int Arch Otorhinolaryngol DOI: 10.1055/s-0036-1579742 Introduction The structural changes underlying permanent noise-induced hearing loss (NIHL) include loss of the sensory hair cells, damage to their stereocilia, and supporting tissues within the cochlear lateral wall. Objective The objective of this study is to demonstrate curcumin as a safe and effective therapeutic agent in the prevention and treatment for […]
Global Allergy Forum and 3rd Davos Declaration 2015
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Allergy via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YqFplk via IFTTT
Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness.
[image: wk-health-logo.gif] Objectives: Molecular mechanisms linking autonomic dysfunction with poorer clinical outcomes in critical illness remain unclear. We hypothesized that baroreflex dysfunction alone is sufficient to cause cardiac impairment through neurohormonal activation of (nicotinamide adenine dinucleotide phosphate oxidase dependent) oxidative stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regulator of cardiac function. Design: Laboratory/clinical investigations. Setting: University laboratory/medical centers. Subjects: ... περισσότερα »
Topographical and functional anatomy of trapezius muscle innervation by spinal accessory nerve and C2 to C4 nerves of cervical plexus
Abstract The aim of this study was to determine the existence and the frequency of communicating branches between the spinal accessory nerve (SAN) and the C2, C3 and C4 roots of the cervical plexus. The present study also aimed to elucidate whether these branches contain motor fibers or not. Dissection of the cervical region was performed on twelve adult cadavers. A powered operating microscope was necessary to dissect the SAN and its branches and also to dissect C2, C3 and C4 nerve branches. In a second step, data from 13 patients who underwent 25 modified neck dissections under t...περισσότερα »
Interference with daily activities and major adverse events during esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter: a systematic review of randomized controlled trials
Summary For three decades, ambulatory 24-hour intranasal pH monitoring has been the established gold standard for detecting acid reflux in patients with refractory gastroesophageal reflux disease. However, device-associated adverse events and unpleasant experiences, reported by patients during pH monitoring have led to the invention of more convenient pH monitors such as Bravo wireless capsule. To compare the interference with daily activities and major adverse events during pH monitoring with Bravo wireless capsule (Bravo) versus conventional intranasal catheter (catheter), PubMed...περισσότερα »
Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns
Summary The rate of lymph-node (LN) metastasis in early adenocarcinoma (EAC) of the esophagus with mid to deep submucosal invasion (pT1b sm2/3) has not yet been precisely defined. The aim of the this study was to evaluate the rate of LN metastasis in pT1b sm2/3 EAC depending on macroscopic and histological risk patterns to find out whether there may also be options for endoscopic therapy as in cancers limited to the mucosa and the upper third of the submucosa. A total of 1.718 pt with suspicion of EAC were referred for endoscopic treatment (ET) to the Dept. of Internal Medicine II ...περισσότερα »
Faecal chitinase 3-like 1 is a reliable marker as accurate as faecal calprotectin in detecting endoscopic activity in adult patients with inflammatory bowel diseases
[image: cover.gif?v=1&s=7839f76471d415b6065969f1] Summary Background Faecal biomarkers are emerging tools in the assessment of mucosal healing in inflammatory bowel diseases (IBDs). Aim To evaluate the accuracy of faecal chitinase 3-like 1(CHI3L1) compared to calprotectin in detecting endoscopic activity in IBD. Methods Overall, 86 IBD adults underwent colonoscopy consecutively and prospectively, with Crohn's disease Endoscopic Index of Severity (CDEIS) or Mayo endoscopic subscore calculation for ulcerative colitis, and stool collection. Faecal calprotectin was measured using ... περισσότερα »
Interference with daily activities and major adverse events during esophageal pH monitoring with bravo wireless capsule versus conventional intranasal catheter: a systematic review of randomized controlled trials
Summary For three decades, ambulatory 24-hour intranasal pH monitoring has been the established gold standard for detecting acid reflux in patients with refractory gastroesophageal reflux disease. However, device-associated adverse events and unpleasant experiences, reported by patients during pH monitoring have led to the invention of more convenient pH monitors such as Bravo wireless capsule. To compare the interference with daily activities and major adverse events during pH monitoring with Bravo wireless capsule (Bravo) versus conventional intranasal catheter (catheter), PubMed...περισσότερα »
Early-stage adenocarcinoma of the esophagus with mid to deep submucosal invasion (pT1b sm2-3): the frequency of lymph-node metastasis depends on macroscopic and histological risk patterns
Summary The rate of lymph-node (LN) metastasis in early adenocarcinoma (EAC) of the esophagus with mid to deep submucosal invasion (pT1b sm2/3) has not yet been precisely defined. The aim of the this study was to evaluate the rate of LN metastasis in pT1b sm2/3 EAC depending on macroscopic and histological risk patterns to find out whether there may also be options for endoscopic therapy as in cancers limited to the mucosa and the upper third of the submucosa. A total of 1.718 pt with suspicion of EAC were referred for endoscopic treatment (ET) to the Dept. of Internal Medicine II ...περισσότερα »
Malnutrition increases NO production and induces changes in inflammatory and oxidative status in the distal colon of lactating rats
Abstract Background Epidemiological studies have indicated the lack of breast feeding as a risk factor associated with later development of inflammatory bowel disease. Nevertheless, the repercussion of little feeding during suckling on large intestine inflammatory response and anti-oxidant resources has not yet been completely understood. This study hypothesized that unfavorable lactation is able to induce oxidative stress and release of inflammatory mediators modifying the integrity of the colon epithelium in weanling rats. Methods Wistar rats were reared under different early n... περισσότερα »
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