Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms
Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms: *Condition*: Esophageal Neoplasms *Interventions*: Procedure: Irreversible electroporation (IRE); Device: NanoKnife *Sponsor*: Fuda Cancer Hospital, Guangzhou ArmsAssigned Interventions Experimental: IRE Group irreversible electroporation for Unresectable Esophageal Neoplasms Procedure: Irreversible electroporation (IRE) Irreversible Electroportion For Unresectable Esophageal Neoplasms guide with ultrasound or/and CT. Other Name: NanoKnife Device: NanoKnife Detailed Description:By enrolling patients wi...περισσότερα »
CMNa Combined With Concurrent Chemoradiotherapy for Locally Recurrent ESCC
A Trial of CMNa Combined With Concurrent Chemoradiotherapy for Locally Recurrent ESCC: *Condition*: Esophageal Neoplasms *Intervention*: Drug: Sodium Glycididazole *Sponsor*: Shandong Cancer Hospital and Institute ArmsAssigned Interventions Experimental: Sodium Glycididazole Sodium Glycididazole：700mg/m2，dissolved in 100ml physiological saline(Now with chef),ivgtt,finished in 30 minutes,within 60 minutes after intravenous drip for radiation therapy.Three times a week (once every other one day),before radiation therapy, total 5-6 weeks course. Chemotherapy Paclitaxel:45 mg/ m...περισσότερα »
Level I substation node counts in oropharyngeal carcinoma
Feasibility and relevance of level I substation node counts in oropharyngeal carcinoma: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background The inclusion of level I in neck dissections for oropharyngeal carcinoma remains controversial. Our objectives were to evaluate the feasibility and relevance of substation node counts in level I of the neck dissection and to determine the specific substation location of metastases in level I in oropharyngeal carcinoma. Methods Sixty specimens were retrospectively analyzed after an orientation using a new paradigm of demarca... περισσότερα »
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background We analyzed local control and early ocular toxicity after eye-sparing management of lacrimal gland carcinoma. Methods For consecutive patients with lacrimal gland carcinoma treated during 2007 to 2014, we reviewed tumor characteristics, treatment details, ocular toxic effects, and recurrence. Results Twenty patients, median age 55 years, were treated for lacrimal gland carcinoma during the study period; 11 had globe-sparing s... περισσότερα »
Technique for reliable sentinel node biopsy in squamous cell carcinomas of the floor of mouth
Technique for reliable sentinel node biopsy in squamous cell carcinomas of the floor of mouth: Abstract Background Applicability of sentinel node biopsy (SNB) for tumors of the floor of mouth (FOM) is controversial. Methods Prospective evaluation of the accuracy of gamma-probe-guided superselective neck dissection of the preglandular triangle of level I for SNB in FOM squamous cell carcinoma (SCC) after preoperative lymphoscintigraphy and single photon emission CT (SPECT)/CT. Results In total, 22 sentinel lymph nodes were harvested in level I. Eight of 22 (36%) were seen on lymphosc...περισσότερα »
Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature
Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature: Abstract Background Mucositis is a disabling effect of radiotherapy in head and neck cancers. There is no current standard on management of radiation-induced mucositis. Honey has been shown to reduce radiation-induced mucositis. Methods A systematic review and meta-analysis were undertaken to assess the ability of honey in reducing the severity of oral mucositis, ti... περισσότερα »
Recommended European Society of Parenteral and Enteral Nutrition protein and energy intakes and weight loss in patients with head and neck cancer
Recommended European Society of Parenteral and Enteral Nutrition protein and energy intakes and weight loss in patients with head and neck cancer: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Information regarding attenuation of weight loss in patients with head and neck cancer consuming energy and protein intakes at levels recommended by the European Society of Parenteral and Enteral Nutrition (ESPEN) is limited. Methods Newly diagnosed patients with head and neck cancer (*n* = 38) consuming food orally had weight and 3-day diet records prospectively coll...περισσότερα »
Free sural artery perforator flap for oral cavity reconstruction
Free sural artery perforator flap: An occasional gift in oral cavity reconstruction: Abstract Background The medial sural artery perforator (MSAP) flap is becoming a popular strategy for reconstructing intraoral defects. We present a case in which no MSAPs were present, however, a perforator-based calf flap was successfully raised on the sural artery and used for tongue reconstruction. A corresponding anatomic study was undertaken to establish if this finding was reproducible. Methods A 58-year-old woman underwent left hemiglossectomy for a squamous cell carcinoma of the tongue. Su... περισσότερα »
Esthesioneuroblastoma with bilateral metastases to the parotid glands
Esthesioneuroblastoma with bilateral metastases to the parotid glands: Abstract Background Esthesioneuroblastoma (ENB) is a rare, poorly characterized, intranasal cancer arising from olfactory neuroepithelium. Methods This case report reviews the underlying pathophysiology, clinical presentation, and diagnosis of primary ENB and parotid metastases. Results We present the case of a 43-year-old man who was referred to our practice with radiographically and biopsy confirmed ENB. After neoadjuvant chemotherapy, radiation, and open surgical resection, he returned to the clinic 30 months p...περισσότερα »
Inflammatory myofibroblastic tumor of carotid artery resulting in recurrent syncope
A case report: Abstract Background Inflammatory myofibroblastic tumor rarely occurs in the carotid artery, whereas syncope is infrequently associated with neck mass. Methods and Results We reby present a case in which a 56-year-old man with inflammatory myofibroblastic tumor at the left carotid bifurcation and is accompanied by recurrent syncope and falls. He underwent surgery, after which corticosteroids and antibiotics were administered for a short term. No recurrence was observed during the 2-year follow-up. Conclusion To our knowledge, this is the first case of inflammatory myofi...περισσότερα »
Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis
Effect of actionable somatic mutations on racial/ethnic disparities in head and neck cancer prognosis: Abstract Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and minorities have the worst survival. However, the molecular mechanisms underlying survival disparities have not been elucidated. Methods In a retrospective study, we assessed association between HNSCC early death (<2 years) and 208 somatic mutations of 10 cancer-related genes in 214 patients: 98 non-Hispanic whites (46%), 72 Hispanic whites (34%), and 44 African Americans...περισσότερα »
Nuclear protein in testis midline carcinoma of larynx
An underdiagnosed entity: [image: cover.gif?v=1&s=70581b04a54536cb9ca48b6d] Abstract Background Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluatio... περισσότερα »
Extramedullary Plasmacytoma of the Paranasal Sinuses: Combining Surgery with External Radiotherapy
Extramedullary Plasmacytoma of the Paranasal Sinuses: Combining Surgery with External Radiotherapy: AbstractExtramedullary plasmacytomas (EMP) are rare neoplasms characterized by the proliferation of a single B-lymphoid cell clone, arising primarily in the head and neck region. The purpose of this study is to report our experience in the management of EMPs arising in the paranasal sinuses. We retrospectively reviewed clinical records of 7 patients (4 men and 3 women), admitted between 1995 and 2010 for EMPs of the paranasal sinuses—5 within the ethmoid and 2 in the maxillary sinus.... περισσότερα »
Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis
Abstract Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that sex-determining region Y-box 17 (Sox17) is directly targeted by miR-595. We then demonstrated that IL-22 regulated migration and invasion of PTC cells via inhibiting Sox17 ... περισσότερα »
Epistaxis Due to Leech Infestation in Nose
A Report of Six Cases and Review of Literature: AbstractThe aim of this study is to report unusual cause of epistaxis due to leech infestation in nose in hilly area and its management. The study was carried out for a period of 4 years (2008–2012) in a secondary level hospital in hilly area of Darjeeling, West Bengal, India with data collected from the OPD and Emergency register of the patients. This retrospective case series consisted of six cases. All the cases presented with unilateral recurrent epistaxis and foreign body nose. Anterior rhinoscopy revealed fleshy greenish brown m... περισσότερα »
Post Tracheostomy Carotid-Tracheal Fistula
Post Tracheostomy Carotid-Tracheal Fistula: AbstractTracheostomy is the life saving procedure in patients presenting with upper airway obstruction. The procedure is also performed in patients on chronic ventilatory support. It is generally considered a safe procedure with a low complication rate. Vascular injuries are the most serious and life threatening complications. Injury to a high lying innominate artery is the most frequent vascular injury in such cases. Injury to other vessels e.g. carotid arteries is less frequent. We are presenting one such rare type of vascular injury wi... περισσότερα »
The Blood Pressure of Hypertensive Patients with Deviated Nasal Septum
Impact of Septal Correction on the Blood Pressure of Hypertensive Patients with Deviated Nasal Septum: AbstractThis study aims to evaluate the effect of septal correction on the blood pressure (BP) of patients with symptomatic nasal septal deviation and to assess whether a positive association exists between deviated nasal septum and hypertension. A prospective observational clinical study was conducted at Kempegowda Institute of Medical Sciences, Bangalore. Hundred adults, aged 18–40 years, with symptomatic nasal septal deviation, newly detected untreated hypertension (mean BP ≥14...περισσότερα »
A Design Methodology for Medical Processes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 11 δευτερόλεπτα
Background: Healthcare processes, especially those belonging to the clinical domain, are acknowledged as complex and characterized by the dynamic nature of the diagnosis, the variability of the decisions made by experts driven by their experiences, the local constraints, the patient’s needs, the uncertainty of the patient’s response, and the indeterminacy of patient’s compliance to treatment. […]
Case of giant cell arteritis as a manifestation of immunoglobulin G4-related disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 11 δευτερόλεπτα
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Acute development of keratoacanthoma at a full-thickness skin graft donor site shortly after surgery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SlQBL9 via IFTTT
Nodular fasciitis on the face
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Acquired reactive perforating collagenosis associated with systemic lupus erythematosus
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Case of facial pyoderma gangrenosum
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
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Eosinophilic pustular folliculitis: A proposal of diagnostic and therapeutic algorithms
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract Eosinophilic pustular folliculitis (EPF) is a sterile inflammatory dermatosis of unknown etiology. In addition to classic EPF, which affects otherwise healthy individuals, an immunocompromised state can cause immunosuppression-associated EPF (IS-EPF), which may be referred to dermatologists in inpatient services for assessments. Infancy-associated EPF (I-EPF) is the least characterized subtype, being observed mainly in non-Japanese […]
Experts call for younger men to be offered PSA test for prostate cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Clinicians should consider offering men in their 40s the prostate specific antigen (PSA) test if the men have concerns about prostate cancer or are at higher than average risk of getting the disease,… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22NrATZ via IFTTT
Reminder letters for bowel screening tests improve uptake
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Only four in 10 people aged 55 currently accept the offer of a one-off flexible sigmoidoscopy screening test under NHS England’s bowel scope screening programme, but a reminder letter can boost… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SlQCim via IFTTT
Silver vs White fillings – Salem, Oregon Dentist
The post Silver vs White fillings – Salem, Oregon Dentist appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1RHtflI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Mixed Type Haemangioma of the Inferior Turbinate
: A Rare Cause of Epistaxis: AbstractHaemangiomas of the nasal cavity are rare benign tumours which usually arise in the Kiesselbach triangle of the septum. Mostly they are seen in young population with peak age 20 years. Epistaxis is the most common symptom in these patients. We present a case of a 62-year-old woman with recurrent epistaxis. On examination she had had an obstruction of both nasal cavities. Computed tomography imaging demonstrated a well-defined tumour originating from the posterior tip of the right inferior turbinate, passing into the nasopharynx. The tumour was... περισσότερα »
Mode of recording and modulation frequency effects of auditory steady state response thresholds
Mode of recording and modulation frequency effects of auditory steady state response thresholds via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Bahram Jalaei, Mohd Normani Zakaria IntroductionThe performance of auditory steady state response (ASSR) in threshold testing when recorded ipsilaterally and contralaterally, as well as at low and high modulation frequencies (MFs), has not been systematically studied.ObjectiveTo verify the influences of mode of r...περισσότερα »
Laryngeal tumor in a patient with thyroid papillary cancer: granular cell tumor
A rare laryngeal tumor in a patient with thyroid papillary cancer: granular cell tumor via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Li-Hsiang Cheng, Sheng-Yao Cheng, Yi-Shu Liao, Wen-Sen Lai Figures and tables 1. Table 1 2. [image: Preoperative indirect laryngoscope finding: a white tumor lesion was at right ...] 3. [image: The tumor comprised round or polygonal cells with abundant eosinophilic granular ...] 4. [image: (A) Posi... περισσότερα »
Parotid Masson's tumor.Intravascular papillary endothelial hyperplasia (Masson's tumor) manifesting as a lateral neck mass
: first case report via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Filippo Carta, Sara Sionis, Valeria Ledda, Clara Gerosa, Roberto Puxeddu Intravascular papillary endothelial hyperplasia (*Masson's tumor*) manifesting as a lateral neck mass L Pantanowitz, R Muc, M Spanger… - Ear, Nose and …, 2000 - go.galegroup.com *...* case, the patient's pain might have been caused by the compression of the *parotid* gland and *...* GC, Orizaga M, Gerin-Lajoic J, Cast... περισσότερα »
Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis
Abstract Interleukin-22 (IL-22) is an inflammatory cytokine mainly produced by activated Th17 and Th22 cells. The data presented here demonstrate that IL-22 induced the migration and invasion of papillary thyroid cancer (PTC) cells. MicroRNA expression analysis and functional studies indicated that IL-22-mediated migration and invasion is positively regulated by miR-595. Further mechanistic studies revealed that… Continue reading Interleukin-22 promotes papillary thyroid cancer cell migration and invasion through microRNA-595/Sox17 axis
The Baader-Meinhof phenomenon in ductal carcinoma in situ of the breast
we read with interest the review of Pang et al. published in the annual review issue of Histopathology in January 2016, entitled ‘Ductal carcinoma in situ – update on risk assessment and management’, wherein a concise overview of the diagnosis and present management of DCIS is provided, as well as a comprehensive summary of the… Continue reading The Baader-Meinhof phenomenon in ductal carcinoma in situ of the breast
Primary Intra-articular Sarcoma: A clinicopathologic study of 15 cases
Abstract Aims To assess the clinical and histopathologic spectrum of primary intraarticular sarcomas. Methods 15 patients were identified as having primary intraarticular sarcomas and the clinical and pathologic features were evaluated. Results There were 9 males and 6 females who ranged in age from 16-84 (mean 44) years. All tumours originated in the knee joint.… Continue reading Primary Intra-articular Sarcoma: A clinicopathologic study of 15 cases
Gleason Grade 4 Prostate Adenocarcinoma Patterns: An Inter-observer Agreement Study among Genitourinary Pathologists
Abstract Aims To assess the inter-observer reproducibility of individual Gleason grade 4 growth patterns. Methods Twenty-three genitourinary pathologists participated in the evaluation of 60 selected high-magnification photographs. The selection included 10 cases of Gleason grade 3, 40 Gleason grade 4 (10 per growth pattern) and 10 Gleason grade 5. Participants were asked to select a… Continue reading Gleason Grade 4 Prostate Adenocarcinoma Patterns: An Inter-observer Agreement Study among Genitourinary Pathologists
Speechreading for Presbycusis
Presbycusis: do we have a third ear? via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Luis Reis, Pedro Escada IntroductionAge-related hearing changes are the most frequent cause of sensorineural hearing loss in adults. In the literature no studies exist concerning the importance of speechreading in individuals with presbycusis and, considering the particularities of each language, that explore this subject in Portuguese speakers from Portugal.ObjectivesTo ...περισσότερα »
A rapidly growing anterior neck mass : Thyroid leiomyosarcoma
: presentation of two cases and review of the literature via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Mehmet İlhan Şahin, Alperen Vural, İmdat Yüce, Sedat Çağlı, Kemal Deniz, Ercihan Güney IntroductionLeiomyosarcoma is a tumor which is rarely seen in the thyroid gland. The diagnosis may be difficult and the treatment is controversial.ObjectiveThe objective of the study is to review the literature about a rare malignant disease of the thyroid gland whi... περισσότερα »
Chronic dizziness of peripheral vestibular origin : An anchor system on the stability limit
Immediate effects of an anchor system on the stability limit of individuals with chronic dizziness of peripheral vestibular origin via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 29 March 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Almir Resende Coelho, Ana Paula do Rego Andre, Júlia Licursi Lambertti Perobelli, Lilian Shizuka Sonobe, Daniela Cristina Carvalho de Abreu IntroductionThe symptoms associated with chronic peripheral vestibulopathy exert a negative impact on the independence and quality of life o...περισσότερα »
CTGF is obligatory for TGF-β1 mediated fibrosis in Oral submucous fibrosis (OSMF)
CTGF is obligatory for TGF-β1 mediated fibrosis in OSMF: While reviewing the literature pertaining to the mechanism of fibrosis, with a particular reference to oral submucous fibrosis (OSMF), we found a rather critical association of molecular mediators preceding a fibrotic change (Fig. 1) [1]. OSMF is considered by many as an unsuccessful wound healing process due to persistent injury to the oral mucosa [1–4]. In fibrosis, there is an attempt by the mesenchymal cells to secrete the provisional matrix to restore the tissue barrier function [2–4]. However, persistent activation of me... περισσότερα »
Nasal corticosteroid in preventing regrowth after adenoidectomy
Efficacy of nasal corticosteroid in preventing regrowth after adenoidectomy: One of the most frequent reasons of nasal obstruction and sleep apnea in pediatrics is adenoid hypertrophy. Remaining adenoid tissue can reoccur following hypertrophied adenoid removal and a second operation may be needed. Nasal corticosteroids are utilized in order to reduce adenoid hypertrophy and eliminate adenoidectomy operation. The purpose of our study is to assess the effect of nasal corticosteroid administration after adenoidectomy on adenoid regrowth and symptom scores.
Preventing hypoxemia : Audıtory System in Obstructıve Sleep Apnea Syndrome (Osas)
The Evaluatıon of Audıtory System in Obstructıve Sleep Apnea Syndrome (Osas) Patıents via American Journal of Otolaryngology Publication date: Available online 29 March 2016 *Source:*American Journal of Otolaryngology Author(s): Mahmut Deniz, Zafer Çiftçi, Tolga Ersözlü, Erdoğan Gültekin, Recep Alp ObjectiveThe authors of the present study aimed to investigate the impact of hypoxemia on the auditory functions of OSAS patients and discussed their findings under the scope of the existing literature.Materials and Methods160 patients who underwent a polysomnographic analysis for the diagn... περισσότερα »
T1-T2 Glottic Squamous Cell Carcinoma : Survival Impact of Initial Therapy
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma: Objective Laryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic squamous cell carcinoma treated with either surgery or radiotherapy. Study Design and Setting Administrative database study. Subjects and Methods The US National Cancer Institute’s SEER database (Surveillance, Epidemiology, and End Results) was queried for cases of early glottic cancer (T1-T2N0M0, 1988-2012). We identified 13,312 qualifying cases. ...περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring: Objective In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. Study Design Prospective clinical study. Setting Multicenter, tertiary care hospitals. Subjects and Methods The age range of the 28 participants was 22 to 47 years, and all had been diagnosed with primary snoring by polysomnography. Orthonasal and retronasal olfactory testing was performed using ... περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Chronic exposure to Bisphenol A affects uterine function during early pregnancy in mice Quanxi Li, et al. | Endocrinology | Mar 29, 2016 The effects of Bisphenol A exposure ... περισσότερα »
The Weber's glands are muciparous glands on the side of the tongue. They are a minor salivary gland in the peritonsillar space. The glands are named after German anatomist Moritz Ignaz Weber....Peritonsillar Abscess: Complication of Acute Tonsillitis or Webers Glands Infection?
Peritonsillar Abscess: Complication of Acute Tonsillitis or Webers Glands Infection?: Objective To review the literature concerning the 2 primary hypotheses put forth to explain the pathogenesis of peritonsillar abscess: "the acute tonsillitis hypothesis" (peritonsillar abscess is a complication of acute tonsillitis) and "the Weber gland hypothesis" (peritonsillar abscess is an infection of Weber’s glands). Data Sources PubMed, EMBASE. Review Methods Data supporting or negating one hypothesis or the other were elicited from the literature. Conclusions Several findings support t... περισσότερα »
Laryngeal Preservation in Glottic Cancer
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options: Objective When total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment options are available for early and advanced glottic cancers due to equivalent locoregional control and survival rates. However, in today’s climate of accountable care, the financial burden of treatment choices continues to increase in significance. We therefore compared hospital charges and ... περισσότερα »
Oral Steroid Usage for Otitis Media with Effusion, Eustachian Tube Dysfunction, and Tympanic Membrane Retraction
Oral Steroid Usage for Otitis Media with Effusion, Eustachian Tube Dysfunction, and Tympanic Membrane Retraction: Objectives Avoiding oral steroids for otitis media with effusion (OME) is endorsed as a performance measure by the National Quality Foundation, but data regarding current gaps and practice patterns are lacking. Our objectives were to evaluate oral steroid use for OME and the related diagnoses of eustachian tube dysfunction (ETD) and tympanic membrane retraction (TMR), to assess variations by visit setting, and to identify opportunities for measurable performance improvem...περισσότερα »
Stress-responsive heme oxygenase-1 isoenzyme participates in Toll-like receptor 4-induced inflammation during brain ischemia
[image: image]Toll-like receptors (TLRs) are involved in the progression of ischemic brain injury and hence vascular dementia; however, the underlying mechanisms are largely unknown. Here, we have investigated the interrelationship between stress-responsive heme oxygenase (HO)-1 isoenzyme and TLR4 during chronic brain hypoperfusion. The right unilateral common carotid artery occlusion was performed by ligation of the right common carotid artery in C57BL/6J mice. The brain cortex or hippocampus was removed for western blotting and confocal immunofluorescence analysis. The link betwee... περισσότερα »
Behavioral characterization of neuropathic pain on the glabrous skin areas reinnervated solely by axotomy-regenerative axons after adult rat sciatic nerve crush
[image: image]In cranial and spinal nerve ganglia, both axotomized primary sensory neurons without regeneration (axotomy-nonregenerative neurons) and spared intact primary sensory neurons adjacent to axotomized neurons (axotomy-spared neurons) have been definitely shown to participate in pain transmission in peripheral neuropathic pain states. However, whether axotomized primary sensory neurons with regeneration (axotomy-regenerative neurons) would be integral components of neural circuits underlying peripheral neuropathic pain states remains controversial. In the present study, we ... περισσότερα »
Imidacloprid toxicity impairs spatial memory of echolocation bats through neural apoptosis in hippocampal CA1 and medial entorhinal cortex areas
[image: image]It has been reported that the decimation of honey bees was because of pesticides of imidacloprid. The imidacloprid is a wildly used neonicotinoid insecticide. However, whether imidacloprid toxicity interferes with the spatial memory of echolocation bats is still unclear. Thus, we compared the spatial memory of Formosan leaf-nosed bats, Hipposideros terasensis, before and after chronic treatment with a low dose of imidacloprid. We observed that stereotyped flight patterns of echolocation bats that received chronic imidacloprid treatment were quite different from their o...περισσότερα »
Human Papillomavirus Vaccination Counseling in Pediatric Training
: Are We Discussing Otolaryngology-Related Manifestations?: Objective Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. Study Design Survey. Setting Tertiary care academic children’s hospital. Subjects Pediatric residents, fellows, and staff. Methods An online survey was made available regarding HPV education and vaccination. Results Participants (N = 348) initiated the survey representing 28.4%, 25.6%, an...περισσότερα »
The Baader-Meinhof phenomenon in ductal carcinoma in situ of the breast
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
we read with interest the review of Pang et al. published in the annual review issue of Histopathology in January 2016, entitled ‘Ductal carcinoma in situ – update on risk assessment and management’, wherein a concise overview of the diagnosis and present management of DCIS is provided, as well as a comprehensive summary of the […]
Primary Intra-articular Sarcoma: A clinicopathologic study of 15 cases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Aims To assess the clinical and histopathologic spectrum of primary intraarticular sarcomas. Methods 15 patients were identified as having primary intraarticular sarcomas and the clinical and pathologic features were evaluated. Results There were 9 males and 6 females who ranged in age from 16-84 (mean 44) years. All tumours originated in the knee joint. […]
Gleason Grade 4 Prostate Adenocarcinoma Patterns: An Inter-observer Agreement Study among Genitourinary Pathologists
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Aims To assess the inter-observer reproducibility of individual Gleason grade 4 growth patterns. Methods Twenty-three genitourinary pathologists participated in the evaluation of 60 selected high-magnification photographs. The selection included 10 cases of Gleason grade 3, 40 Gleason grade 4 (10 per growth pattern) and 10 Gleason grade 5. Participants were asked to select a […]
Response to post-axitinib treatment in patients with metastatic renal cell carcinoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background Axitinib is a potent inhibitor of the vascular endothelial growth factor (VEGF) receptor family with clinical activity in patients with metastatic renal cell carcinoma (mRCC). Given this biochemical potency, the clinical activity of subsequent treatment with targeted therapies in patients progressing on axitinib is of interest. Methods Patients with advanced renal cell carcinoma […]
Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multicenter Study.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Background: Subcutaneous administration of hepatitis B immunoglobulin (HBIg) is effective in preventing hepatitis B virus (HBV) recurrence after liver transplantation, but early conversion to subcutaneous administration is undocumented. Methods: In a prospective study, patients transplanted for terminal liver disease due to HBV infection who were HBV DNA-negative at transplant were switched by week 3 posttransplantation […]
Zika Virus and Solid Organ Transplantation: Significant Pathogen or Harbinger of Things to Come?.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RJNOuE via IFTTT
The 1966 Ciba Symposium on Transplantation Ethics: 50 Years Later.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
In March 1966, the Ciba Foundation sponsored the first international, interdisciplinary symposium focused on ethical and legal issues in transplantation. The attendees included not only physicians and surgeons but also judges and legal scholars, a minister, and a science journalist. In this article, we will consider some of the topics in organ transplantation that were […]
ReCAP: Experience of the National Cancer Institute Community Cancer Centers Program on Community-Based Cancer Clinical Trials Activity Care Delivery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
QUESTION ASKED: Did participation in the National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) impact cancer research capacity in community cancer programs? SUMMARY ANSWER: Despite the short duration, the NCCCP pilot resulted in an increase in the number of open trials and patient accrual at a faster rate than that observed nationally. These results, […]
ReCAP: Low Enrollment of Adolescents and Young Adults Onto Cancer Trials: Insights From the Community Clinical Oncology Program Care Delivery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
QUESTION ASKED: Given the importance of cancer clinical trials and the fact that most adolescents and young adults (AYAs) are treated in the community setting, did historical Community Clinical Oncology Program (CCOP) sites enroll a higher proportion of AYAs to Children’s Oncology Group (COG) studies than non-CCOP sites? SUMMARY ANSWER: Over the 10-year period studied, […]
ReCAP: Journey Toward High Reliability: A Comprehensive Safety Program to Improve Quality of Care and Safety Culture in a Large, Multisite Radiation Oncology Department Focus on Quality
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
QUESTION ASKED: What is the impact of a comprehensive, multifaceted quality and safety improvement program on the frequency of state-reported medical safety events (SRMEs) and overall safety culture in a large, multisite radiation oncology department at the University of Pennsylvania? SUMMARY ANSWER: Multifaceted safety initiatives were implemented at the main academic center and across all […]
Biomechanical, micro-computed tomographic and immunohistochemical analysis of early osseous integration at titanium implants placed following lateral ridge augmentation using extracted tooth roots
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Abstract Objectives To assess biomechanical, micro-computed tomographic (micro CT) and immunohistochemical characteristics of early osseous integration at titanium implants placed following lateral ridge augmentation using autogenous extracted tooth roots. Material & Methods The roots of healthy maxillary premolars (PM) and retromolar cortical autogenous bone (AB) blocks were used for lateral ridge augmentation at chronic-type defects […]
Evaluation of zirconia-based posterior single crowns supported by zirconia implants: preliminary results of a prospective multicenter study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Abstract Objective The aim of this uncontrolled prospective multicenter study was to determine the success and survival rate of posterior single crowns composed of zirconia frameworks hand-layered with a leucite-reinforced feldspathic ceramic supported by one-piece zirconia oral implants. Material and methods In two centers, sixty patients received 71 zirconia oral implants. To obtain a clear […]
The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article Restricting hypertrophic heart growth in response to pathologic overload is an unmet therapeutic need. Here, the authors show that blocking Ca 2+ signaling controlled by the transport protein PMCA4 in cardiac fibroblasts enhances secretion of a potent Wnt signaling inhibitor, sFRP2, and prevents the development of pathologic cardiac hypertrophy in mice. Nature Communications doi: […]
Structure of the full-length TRPV2 channel by cryo-EM
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article Transient receptor potential (TRP) proteins are Ca 2+ -permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation of the TRPV subfamily of channels. Nature Communications doi: 10.1038/ncomms11130 Authors: Kevin W. Huynh, Matthew R. […]
Energy cost and return for hunting in African wild dogs and cheetahs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article The long-distance hunting behaviour of African wild dogs is thought to be energetically costly. Here, Hubel et al . show that multiple opportunistic short-distance hunts and group feeding make African wild dogs in mixed woodland savannah energetically robust. Nature Communications doi: 10.1038/ncomms11034 Authors: Tatjana Y. Hubel, Julia P. Myatt, Neil R. Jordan, Oliver P. […]
Microelectromechanical reprogrammable logic device
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article Microelectromechanical resonators behave as logic gates thanks to the tunability of their resonance frequencies. Here, the authors combine the mechanical response to electrothermal frequency modulation to demonstrate 2- and 3-bit reprogrammable logic gates at room temperature and under modest vacuum. Nature Communications doi: 10.1038/ncomms11137 Authors: M. A. A. Hafiz, L. Kosuru, M. I. Younis […]
Additive opportunistic capture explains group hunting benefits in African wild dogs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article African wild dogs hunt collaboratively over long distances in grassland plains. Hubel et al . use high-resolution GPS to show that in their remaining habitat of mixed woodland savannah, African wild dogs use multiple opportunistic short-distance hunts, with no evidence of cooperative chasing. Nature Communications doi: 10.1038/ncomms11033 Authors: Tatjana Y. Hubel, Julia P. Myatt, […]
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article Epileptic brains display inhibitory restraint as manifested by the spread of synchronized activities being delayed in timing. Here, Elliot Smith and colleagues show fast-moving traveling wave that originates from the edge of ictal wavefront with subsequent depolarization and multiunit firing in the seizing brain regions in epileptic patients. Nature Communications doi: 10.1038/ncomms11098 Authors: Elliot […]
Unpredictable environments lead to the evolution of parental neglect in birds
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article The response of parents to offspring begging behaviour is hugely variable in birds, but what mediates this response is not known. In a meta-analysis across 143 species, Caro et al . show that variation in offspring begging and parental care is a function of environmental quality and predictability. Nature Communications doi: 10.1038/ncomms10985 Authors: Shana […]
Computations of uncertainty mediate acute stress responses in humans
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 55 δευτερόλεπτα
Article Acute stress has broad physiological and behavioural consequences, yet the precise factors that generate stress responses are not known. Here, de Berker and colleagues demonstrate that acute stress responses dynamically track environmental uncertainty and predict ability to learn under uncertain threat. Nature Communications doi: 10.1038/ncomms10996 Authors: Archy O. de Berker, Robb B. Rutledge, Christoph […]
Metabolic Syndrome and Periodontal Disease Progression in Men
Metabolic syndrome, a cluster of 3 or more risk factors for cardiovascular disease, is associated with periodontal disease, but few studies have been prospective in design. This study's aim was to determine whether metabolic syndrome predicts tooth loss and worsening of periodontal disease in a cohort of 760 men in the Department of Veterans Affairs Dental Longitudinal Study and Normative Aging Study who were followed up to 33 y from 1981 to 2013. Systolic and diastolic blood pressures were measured with a standard mercury sphygmomanometer. Waist circumference was measured in units...περισσότερα »
Biomechanical, micro-computed tomographic and immunohistochemical analysis of early osseous integration at titanium implants placed following lateral ridge augmentation using extracted tooth roots
Abstract Objectives To assess biomechanical, micro-computed tomographic (micro CT) and immunohistochemical characteristics of early osseous integration at titanium implants placed following lateral ridge augmentation using autogenous extracted tooth roots. Material & Methods The roots of healthy maxillary premolars (PM) and retromolar cortical autogenous bone (AB) blocks were used for lateral ridge augmentation at chronic-type defects in the lower quadrants of *n* = 16 foxhounds. At 12 weeks, titanium implants were inserted and left to heal for another 3 weeks. Osteocalcin (OC) ... περισσότερα »
Nicotine excites corticotropin-releasing hormone mRNA-expressing neuron in the hypothalamic paraventricular nucleus in vitro in rats.
Nicotine is known to modulate the activity of the hypothalamic-pituitary-adrenal axis by stimulating corticotropin-releasing hormone (CRH) release from the hypothalamic paraventricular nucleus (PVN). However, the mechanism by which nicotine affects the hypothalamic-pituitary-adrenal axis by modulating PVN CRH neuronal activity is currently unclear. Here, we examined the effects of nicotine on PVN CRH-mRNA-expressing neurons in vitro in rats by whole-cell patch-clamp recordings, biocytin staining, and single-cell reverse transcription-multiplex PCR techniques. Of the 146 PVN putative...περισσότερα »
My name or yours? Event-related potential correlates of self-name processing.
This electrophysiological study examined the roles of self-specificity (designating the participant: 'me' vs. 'not-me'), self-relevance (degree of relevance to the participant: high self-relevance vs. less self-relevance), and familiarity (the frequency of occurrence in daily routine: high familiarity vs. less familiarity) in the preferential processing of self-name (SN) by comparing the processing of SN (i.e. the participant's name being of 'me', high self-relevance and high familiarity) with the processing of a close other's name (CON) (e.g. the participant's father's name being o... περισσότερα »
Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease
Abstract Objective Cognitive decline occurs in multiple neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Shared underlying mechanisms may exist and manifest as shared biomarker signatures. Previously, we nominated plasma epidermal growth factor (EGF) as a biomarker predicting cognitive decline in patients with established PD. Here, we investigate EGF as a predictive biomarker in prodromal PD, as well as AD. Methods A cohort of PD patients (*n* = 236) was recruited to replicate our finding that low baseline EGF levels predict future cog... περισσότερα »
Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multicenter Study.
Background: Subcutaneous administration of hepatitis B immunoglobulin (HBIg) is effective in preventing hepatitis B virus (HBV) recurrence after liver transplantation, but early conversion to subcutaneous administration is undocumented. Methods: In a prospective study, patients transplanted for terminal liver disease due to HBV infection who were HBV DNA-negative at transplant were switched by week 3 posttransplantation from intravenous to subcutaneous HBIg (500 or 1000 IU weekly or fortnightly, adjusted according to serum anti-HBs trough level) if they were HBsAg- and HBV-DNA negati...περισσότερα »
Zika Virus and Solid Organ Transplantation: Significant Pathogen or Harbinger of Things to Come?.
No abstract available from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1RJNOuE via IFTTT
The 1966 Ciba Symposium on Transplantation Ethics: 50 Years Later.
In March 1966, the Ciba Foundation sponsored the first international, interdisciplinary symposium focused on ethical and legal issues in transplantation. The attendees included not only physicians and surgeons but also judges and legal scholars, a minister, and a science journalist. In this article, we will consider some of the topics in organ transplantation that were discussed by the attendees, what we have learned in the intervening half century, and the relevance of their discussions today. Specifically, we examine the definition of death and its implications for organ procureme... περισσότερα »
Patterns of impaired oral health-related quality of life dimensions
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Summary How dental patients are affected by oral conditions can be described with the concept of oral health-related quality of life (OHRQoL). This concept intends to make the patient experience measurable. OHRQoL is multidimensional, and *Oral Function*, *Oro-facial Pain*, *Oro-facial Appearance* and *Psychosocial Impact* were suggested as its four dimensions and consequently four scores are needed for comprehensive OHRQoL assessment. When only the presence of dimensional impact is measured, a pattern of affected OHRQoL dimensions would describe in a simple way how oral condition...περισσότερα »
The Pursuit of Otolaryngology Subspecialty Fellowships
The Pursuit of Otolaryngology Subspecialty Fellowships: Objectives To examine otolaryngology resident interest in subspecialty fellowship training and factors affecting interest over time and over the course of residency training Study Design Cross-sectional study of anonymous online survey data. Setting Residents and fellows registered as members-in-training through the American Academy of Otolaryngology–Head and Neck Surgery. Subjects and Methods Data regarding fellowship interest and influencing factors, including demographics, were extracted from the Section for Residents and...περισσότερα »
Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs
Effects of Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs: Objective To explore whether memantine, an *N-*methyl-D-aspartate receptor antagonist, exerts a neuroprotective effect against apoptosis of spiral ganglion cells (SGCs) induced by gentamicin. Study Design An animal experiment. Setting Dong-A University College of Medicine, Busan, Korea. Subjects and Methods Gentamicin was injected into the left cochleae of guinea pigs to induce apoptosis of SGCs; the contralateral cochleae served as controls. Memantine was intraperitoneally injected... περισσότερα »
Management Strategies for Skull Base Inverted Papilloma
Management Strategies for Skull Base Inverted Papilloma: Objective Inverted papilloma attached to the ventral skull base presents a surgical dilemma because surgical removal of the bony pedicle is critical to decrease risk of recurrence. The objective of this study is to evaluate the effectiveness of endoscopic management of skull base inverted papilloma. Study Design Case series with planned data collection. Setting Tertiary medical center. Subjects Patients with skull base inverted papilloma. Methods Over 7 years, 49 patients with skull base inverted papilloma were referred f... περισσότερα »
Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multicenter Study.
Background: Subcutaneous administration of hepatitis B immunoglobulin (HBIg) is effective in preventing hepatitis B virus (HBV) recurrence after liver transplantation, but early conversion to subcutaneous administration is undocumented. Methods: In a prospective study, patients transplanted for terminal liver disease due to HBV infection who were HBV DNA-negative at transplant were switched by week 3 posttransplantation… Continue reading Early Introduction of Subcutaneous Hepatitis B Immunoglobulin Following Liver Transplantation for Hepatitis B Virus Infection: A Prospective, Multi... περισσότερα »
Zika Virus and Solid Organ Transplantation: Significant Pathogen or Harbinger of Things to Come?.
No abstract available from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1RJNOuE via IFTTT
The 1966 Ciba Symposium on Transplantation Ethics: 50 Years Later.
In March 1966, the Ciba Foundation sponsored the first international, interdisciplinary symposium focused on ethical and legal issues in transplantation. The attendees included not only physicians and surgeons but also judges and legal scholars, a minister, and a science journalist. In this article, we will consider some of the topics in organ transplantation that were… Continue reading The 1966 Ciba Symposium on Transplantation Ethics: 50 Years Later.
Materials, Vol. 9, Pages 246: An Effective Electrodeposition Mode for Porous MnO2/Ni Foam Composite for Asymmetric Supercapacitors
Three kinds of MnO2/Ni foam composite electrode with hierarchical meso-macroporous structures were prepared using potentiodynamic (PD), potentiostatic (PS), and a combination of PS and PD(PS + PD) modes of electrodeposition. The electrodeposition mode markedly influenced the surface morphological, textural, and supercapacitive properties of the MnO2/Ni electrodes. The supercapacitive performance of the MnO2/Ni electrode obtained via PS + PD(PS + PD(MnO2/Ni)) was found to be superior to those of MnO2/Ni electrodes obtained via PD and PS, respectively. Moreover, an asymmetric superc... περισσότερα »
Survival and Prognosis for Malignant Tumors of Odontogenic Origin
Survival and Prognosis for Malignant Tumors of Odontogenic Origin: Objective Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. Study Design Retrospective analysis of the National Cancer Institute’s SEER database (Surveillance, Epidemiology, and End Results). Setting Tertiary medical center. Subjects and Methods All cases of malignant tumors of odontogenic origin were extracted from the SEER database for the period of 1973 to 2011. Demographic, tumor-specific, and survival data were tabulated and Kaplan-Meier survival analy... περισσότερα »
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population: Objective To report on the prevalence of voice disturbances in the pediatric craniofacial population and to prove that the pediatric Voice Handicap Index (pVHI) is a useful questionnaire for this unique population. Study Design Case series with chart review. Setting Tertiary care center. Subjects Pediatric patients seen by a pediatric otolaryngologist in a craniofacial clinic. Methods Consecutive patients (N = 366) seen by a single pediatric otolaryngologist in a craniofacial clinic from July 20... περισσότερα »
Sudden-Onset Sensorineural Hearing Loss after Immunization
Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis: Objective Case reports of sudden sensorineural hearing loss (SSHL) following vaccines have led to concerns that vaccines may rarely cause hearing loss. Because of this concern, we analyzed for an association between SSHL and vaccinations. Study Design We used a case-centered method, equivalent to a case control design using immunization dates from all matched members of the population to calculate exposure to vaccines, rather than sampling. Setting Kaiser Permanente Northern California (KPNC), 2...περισσότερα »
Die Tracheostomaepithese – eine Evaluation der Patientenzufriedenheit
Die Tracheostomaepithese – eine Evaluation der Patientenzufriedenheit: Zusammenfassung HintergrundEpithesen werden mit großem Erfolg zur Versorgung von Defekten im Kopfbereich angewendet. Der Gebrauch einer Epithese für die erfolgreiche Stimmrehabilitation eines schwer zu versorgenden Tracheostomas ist dagegen eher unbekannt. Die vorliegende Arbeit beschreibt die Methodik der Tracheostomaepithese, berichtet von den Patientenerfahrungen und beinhaltet eine systematische Auswertung der funktionellen Ergebnisse nach der Stomaepithesenversorgung. Material und MethodeDie retrospekti... περισσότερα »
Active Middle Ear Implantation
Active Middle Ear Implantation: Long-term Medical and Technical Follow-up, Implant Survival, and Complications.: Objective: To evaluate the long-term medical and technical results, implant survival, and complications of the semi-implantable vibrant soundbridge (VSB), otologics middle ear transducer (MET), and the otologics fully implantable ossicular stimulator (FIMOS). Study Design: Retrospective cohort study. Patients: Patients with chronic external otitis and either moderate to severe sensorineural or conductive/mixed hearing loss. Setting: Tertiary referral center. Intervention... περισσότερα »
Diagnosis of Vascular Pulsatile Tinnitus by Transcanal Sound Recording and Spectrotemporal Analysis
Objectification and Differential Diagnosis of Vascular Pulsatile Tinnitus by Transcanal Sound Recording and Spectrotemporal Analysis: A Preliminary Study.: Objective: Although frequently classified as "objective tinnitus," in most cases vascular pulsatile tinnitus (VPT) is not equal to objective tinnitus because it is not easy to objectively document VPT. The present study was conducted to develop a novel transcanal sound recording and spectrotemporal analysis method for the objective and differential diagnosis of VPT. Study Design: A case series with a control group. Setting: Tert... περισσότερα »
Microsurgical Anatomy of the Internal Acoustic Meatus as Seen Using the Retrosigmoid Approach.
Microsurgical Anatomy of the Internal Acoustic Meatus as Seen Using the Retrosigmoid Approach.: Hypothesis: To show via a retrosigmoid approach the bony labyrinth anatomy and its relationship with the internal acoustic meatus so as to provide guidelines for a safer drilling to the fundus using this approach. Background: Few studies deal with the complex anatomy of petrous bone structures as observed by a retrosigmoid approach. Methods: Ten retrosigmoid approaches were performed bilaterally on five fresh cadaveric heads. Afterward high-resolution computed tomographic scans were obta...περισσότερα »
Mastoid and Epitympanic Bony Obliteration (CWR-BOT)
Long-term Results of Troublesome CWD Cavity Reconstruction by Mastoid and Epitympanic Bony Obliteration (CWR-BOT) in Adults.: Objective: To present the long-term surgical outcome of the bony mastoid and epitympanic obliteration technique with canal wall reconstruction (CWR-BOT) in adults with an unstable cavity after previous canal wall-down surgery for extensive cholesteatoma. Study Design: Retrospective study. Interventions: Therapeutic. Setting: Tertiary referral center. Patients: Fifty consecutive adult patients undergoing a CWR-BOT between 1998 and 2009. Main Outcome Measure...περισσότερα »
Collagenous Matrices of Xenogenic Origin for Tympanic Membrane Reconstruction
Acoustic Properties of .: Hypothesis: The acoustic properties of scaffolds made from decellularized extracellular cartilage matrices of porcine origin are comparable to those of the human tympanic membrane. Background: Currently, the reconstruction of tympanic membrane in the context of chronic tympanic membrane defects is mostly performed using autologous fascia or cartilage. Autologous tissue may be associated with lack of graft material in revision patients and requires more invasive and longer operative time. Therefore, other materials are investigated for reconstruction. An inc...περισσότερα »
TGF-ß1 in osteoarthritis of the temporomandibular joint
The role of TGF-ß1 in osteoarthritis of the temporomandibular joint in two genetic mouse models via Oral Biology Publication date: July 2016 *Source:*Archives of Oral Biology, Volume 67 Author(s): E. Long, R. Motwani, D. Reece, N. Pettit, J. Hepworth, P. Wong, P. Reynolds, R. Seegmiller ObjectiveThe objective of this study is to elucidate osteoarthritis (OA) progression in the temporomandibular joint (TMJ) in two genetic mouse models by assessing the expression of an identified inflammatory marker associated with OA, viz., Tgf-ß1. This study provides mechanistic insight into disease p...περισσότερα »
Unilateral posterior crossbite : Masseter activity and chewing kinematics
Effects of therapy on masseter activity and chewing kinematics in patients with unilateral posterior crossbite via Oral Biology Publication date: July 2016 *Source:*Archives of Oral Biology, Volume 67 Author(s): Maria Grazia Piancino, Deborah Falla, Andrea Merlo, Teresa Vallelonga, Corrado de Biase, Domenico Dalessandri, Cesare Debernardi ObjectiveTo describe the effects of therapy on masseter activity and chewing kinematic in patients with unilateral posterior crossbite (UPC).DesignFifty children (age: mean±SD: 9.1±2.3years) with UPC (34 on the right side, 16 on the left side) and twe...περισσότερα »
Y a-t-il un médecin dans la pharmacie ?
from Pharmacology via ola Kala on Inoreader http://ift.tt/1pI94KQ via IFTTT
Revue commentée de plantes médicinales
Résumé Une étude a eu pour objectif de voir si des extraits de ginseng rouge coréen (EPG) pouvaient améliorer la fonction sexuelle chez les femmes préménopausées. Quarante et une femmes préménopausées ont participé à cette étude clinique contrôlée contre placebo en double aveugle en cross over avec l'administration soit de trois capsules de ginseng (à 1 g par capsule) ou d'un placebo tous les jours. L'efficacité de l'EPG a été mesurée en utilisant l'Index de la Fonction Sexuelle de la Femme (FSF). Vingt-trois femmes ont terminé l'étude. Les scores totaux du FSF ont augmenté après l... περισσότερα »
Materials, Vol. 9, Pages 251: Removal of 4-Chlorophenol from Contaminated Water Using Activated Carbon from Dried Date Pits: Equilibrium, Kinetics, and Thermodynamics Analyses
Five different activated carbons (ACs) have been prepared from dried date pits using air and phosphoric acid as activating agents. The used phosphoric acid:date pit ratio dictated the characteristics of the prepared ACs; the equivalent BET-nitrogen surface area varied from 794 m2/g for a ratio of 5:1, to 1707 m2/g for a ratio of 2:1, whereas the micropore volume changed in value from 0.24 cm3/g for the 5:1 ratio to 0.59 cm3/g for the 2:1 ratio. The prepared ACs were tested to remove 4-chlorophenol (4-CP) from aqueous solutions by means of batch adsorption process. The prepared 2:1... περισσότερα »
Antidepressants on parotid salivary secretion
In vivo studies of effects of antidepressants on parotid salivary secretion in the rat via Oral Biology Publication date: July 2016 *Source:*Archives of Oral Biology, Volume 67 Author(s): Martin Johnsson, Michael Winder, Hana Zawia, Ida Lödöen, Gunnar Tobin, Bengt Götrick Tricyclic antidepressants (TCA) are well-known xerogenic drugs, while antidepressants such as selective serotonin reuptake inhibitors (SSRI) are considered less xerogenic. The antimuscarinic effect of the TCAs has been considered to be the principal mechanism causing a dry mouth. Although the muscarinic receptor is c... περισσότερα »
Periodontal disease and Asthma
Relationship between Periodontal disease and Asthma among overweight/obese adults: Abstract Aim To assess the relationship between oral health and asthma. Methods Data from 1,315 overweight or obese individuals, aged 40-65 years was used. Asthma was self-reported, while periodontitis, bleeding on probing (BOP), and plaque index were determined by clinical examinations. Results Using logistic regression adjusting for gender, smoking status, age, body mass index, family history of asthma, and income level, revealed that the odds ratio (OR) of asthma for a participant with severe period...περισσότερα »
Computational prospecting the great viral unknown
Bacteriophage play an important role in host-driven biological processes by controlling bacterial population size, horizontally transferring genes between hosts, and expressing host-derived genes to alter host metabolism. Metagenomics provides the genetic basis for understanding the interplay between uncultured bacteria, their phage, and the environment. In particular, viral metagenomes (viromes) are providing new insight into phage-encoded host genes (i.e., auxiliary metabolic genes; AMGs) that reprogram host metabolism during infection. Yet, despite deep sequencing efforts of vi... περισσότερα »
Purification, characterization, and function analysis of an extracellular {beta}-glucosidase from elongating stipe cell walls in Coprinopsis cinerea
A β-glycoside hydrolase was isolated from cell walls material in *Coprinopsis cinerea* elongating stipes. By analysis of SDS-PAGE, MALDI-TOF/TOF MS and substrate specificity, this enzyme was characterized as an extracellular β-glucosidase which is a trimer consisting of three homo-subunits. β-glucosidase did not degrade β-glucans with modified-ends, whereas it hydrolyzed various β-glucans with free ends and related oligosaccharides with β-1,3-, β-1,4-, or β-1,6-linkages. Although this β-glucosidase possesses glycosyltransferase activity on laminarioligosaccharides, it did not tran...περισσότερα »
Heme sensing in Bacillus thuringiensis: a supplementary HssRS-regulated heme resistance system
Several Gram-positive pathogens scavenge host-derived heme to satisfy their nutritional iron requirement. However, heme is a toxic molecule capable of damaging the bacterial cell. Gram-positive pathogens within the phylum Firmicutes overcome heme toxicity by sensing heme through HssRS, a two-component system that regulates the heme detoxification transporter HrtAB. Here we show that heme sensing by HssRS and heme detoxification by HrtAB occur in the insect pathogen *Bacillus thuringiensis*. We find that in *Bacillus thuringiensis*, HssRS directly regulates an operon, *hrmXY*, enco...περισσότερα »
Cloning and characterization of two thermo- and salt-tolerant oligoalginate lyases from marine bacterium Halomonas sp.
Two new alginate lyase genes, *oalY1* and *oalY2*, have been cloned from the newly isolated marine bacterium *Halomonas* sp. QY114 and expressed in *Escherichia coli*. The deduced alginate lyases, OalY1 and OalY2, belonged to polysaccharide lyase (PL) family 17 and showed less than 45% amino acid identity with all of the characterized oligoalginate lyases. OalY1 and OalY2 exhibited the highest activities at 45°C and 50°C respectively. Both of them showed more than 50% of the highest activity at 60°C, and 20% at 80°C. In addition, they were salt-dependent and salt-tolerant since bot... περισσότερα »
23 COCH mutations causative of DFNA9 autosomal dominant sensorineural hearing loss and vestibular disorder
Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9): The histopathology of the inner ear in a patient with hearing loss caused by the p.L114P *COCH* mutation and its correlation with the clinical phenotype are presented. To date, 23 *COCH* mutations causative of DFNA9 autosomal dominant sensorineural hearing loss and vestibular disorder have been reported, and the histopathology of the human inner ear has been described in 4 of these. The p.L114P *COCH* mutation was first described in a Korean family. We have identified the same mutation in a family of non-Asi... περισσότερα »
Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9)
Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9): The histopathology of the inner ear in a patient with hearing loss caused by the p.L114P *COCH* mutation and its correlation with the clinical phenotype are presented. To date, 23 *COCH* mutations causative of DFNA9 autosomal dominant sensorineural hearing loss and vestibular disorder have been reported, and the histopathology of the human inner ear has been described in 4 of these. The p.L114P *COCH* mutation was first described in a Korean family. We have identified the same mutation in a family of non-Asi... περισσότερα »
A psychoacoustic model of the voicesourcespectrum
Modeling the voice source in terms of spectral slopes [image: cm_sbs_024_plain.png] A psychoacoustic model of the voicesourcespectrum is proposed. The model is characterized by four spectral slope parameters: the difference in amplitude between the first two harmonics (H1–H2), the second and fourth harmonics (H2–H4), the fourth harmonic and the harmonic nearest 2 kHz in frequency (H4–2 kHz), and the harmonic nearest 2 kHz and that nearest 5 kHz (2 kHz–5 kHz). As a step toward model validation, experiments were conducted to establish the acoustic and perceptual independence of these ... περισσότερα »
Robot-assisted manipulation is promising for solving problems such as understaffing and the risk of infection in gastro-intestinal endoscopy
Design and control of a novel gastroscope intervention mechanism with circumferentially pneumatic-driven clamping function by Yanmin Li, Hao Liu, Siwen Hao, Hongyi Li, Jianda Han, Yunsheng Yang via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background Robot-assisted manipulation is promising for solving problems such as understaffing and the risk of infection in gastro-intestinal endoscopy. However, the commonly used friction rollers in few existing systems have a potential risk of deforming flexible endoscopes for non-uniform clamping. Methods... περισσότερα »
Design and control of a novel gastroscope intervention mechanism with circumferentially pneumatic-driven clamping function
Abstract Background Robot-assisted manipulation is promising for solving problems such as understaffing and the risk of infection in gastro-intestinal endoscopy. However, the commonly used friction rollers in few existing systems have a potential risk of deforming flexible endoscopes for non-uniform clamping. Methods This paper presents a robotic system for a standard flexible endoscope and focuses on a novel gastroscope intervention mechanism (GIM), which provides circumferentially uniform clamping with an airbag. The GIM works with a relay-on mechanism in a way similar to manua...περισσότερα »
The Relationship Between Optic Nerve Sheath Decompression Failure and Intracranial Pressure in Idiopathic Intracranial Hypertension.
Background: To our knowledge, there are no studies of patients with idiopathic intracranial hypertension (IIH) that address the relationship between level of intracranial pressure (ICP) and likelihood of progressive visual loss despite uncomplicated optic nerve sheath decompression (ONSD). This study investigated whether patients with IIH undergoing ONSD had a higher risk of surgical failure if opening pressure (OP) on lumbar puncture was >=50 cm H2O compared to those with OP =50 cm H2O, 6 (15%) had progressive visual loss after uncomplicated ONSD, vs 6 (4.5%) of 134 patients with a... περισσότερα »
Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma.
Adult-onset opsoclonus-myoclonus syndrome (OMS) has been associated with multiple cancers, most commonly small-cell lung carcinoma and breast adenocarcinoma. A 53-year-old woman who presented with OMS was found to have primary central nervous system (CNS) diffuse large B-cell lymphoma. OMS has been described in only 5 cases with non-Hodgkin lymphoma (NHL), and this is only the third reported case of OMS in NHL limited to the CNS. Although the paraneoplastic antibody panel was negative, we presume that the OMS was a paraneoplastic manifestation. Antineoplastic and anti-immune therapy... περισσότερα »
Strabismus Surgery in Patients With Ocular Neuromyotonia: Potential Unmasking of the Condition and Effective Management Tool.
Background: Ocular neuromyotonia (ONM) is a rare motility disorder in which paroxysms of tonic extraocular muscle contraction from abnormal ocular motor nerve firing result in episodic diplopia and strabismus. Medical therapy with membrane-stabilizing agents has varied success. A surgical approach to treatment has not yet been described. We report the outcomes of strabismus surgery in patients with ONM. Methods: We describe 3 patients with sixth nerve paresis and ONM of the affected lateral rectus muscle who underwent strabismus surgery. All patients had a history of radiation thera...περισσότερα »
Optic Nerve Fenestration in a Patient With the Syndrome of Acquired Hyperopia and Choroidal Folds.
We performed bilateral optic nerve sheath fenestrations on a patient with the syndrome of acquired hyperopia and choroidal folds. We are unaware of previous reports of this procedure being performed in this clinical setting. Despite the incomplete resolution of his posterior segment findings postoperatively, the results of the procedure, along with an understanding of the relevant anatomy, may help to shed light on the pathogenesis of this rare entity. (C) 2016 by North American Neuro-Ophthalmology Society from Neurology via xlomafota13 on Inoreader http://ift.tt/1ThKlcm via IFTTT
CDK4 inhibitors and tumor cell senescence
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
PML plays a role in the senescence tumor suppressor response of normal cells to oncogenic stress. However, tumor cell lines fail to engage a complete senescence in response to PML activation. Here, we show that the cyclin-dependent kinases CDK4 and CDK6 impair the senescence response to PML expression. Decreasing CDK functions by RNA interference, CDK […]
Membrane IL-1{alpha} inhibits HCC development
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Hepatocellular carcinoma (HCC) is a worldwide health problem with limited treatment options and poor prognosis. Inflammation associated with liver injury and hepatocyte regeneration can lead to fibrosis, cirrhosis, and eventually, HCC. Interleukin-1α (IL-1α) is one of the most important inflammatory cytokines involved in inflammation and tumor development. IL-1α presents as multiple forms in vivo, including […]
C9b regulates the NF-{kappa}B pathway
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Alternate RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b). C9b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non-small cell lung cancer (NSCLC) cells. In this study, we elucidated the mechanistic underpinnings of the malignant character of this splice isoform. In […]
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