Comparing the Performance Status Scale and MD Anderson Dysphagia Inventory as swallowing outcome measures in head and neck cancer: a prospective cohort study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Khan MK, Patterson J, Owen S, Rees S, Gamberini L, Paleri V, North of England Cancer Network Audit group Abstract OBJECTIVES: To examine the relationship between the two disease-specific measures currently in use to assess swallowing outcomes following treatment in patients with head and neck cancer: the Performance Status Scale (PSS) and MD Anderson Dysphagia Inventory (MDADI). DESIGN: A prospective cohort study. SETTING: Four head and neck cancer multidisciplinary clinics in the North of England Cancer Network. PARTIC... περισσότερα »
Dysphagia, dysphonia and sore throat following cerebral infarction
[image: http:--highwire.stanford.edu-icons-exter] Authors: Slade PM, Larsen MP Abstract A 75-year-old woman presented with left-sided weakness. There was no speech disturbance or reported swallowing difficulties. CT of the head revealed infarction in the territory of the right middle cerebral artery. The patient was transferred to the acute stroke unit and a nasogastric tube was placed following a failed swallow screening test. The following day, on assessment, there was considerable pain on swallowing. The tone and quality of the patient's voice had deteriorated and there was si... περισσότερα »
Observation versus embolization in patients with blunt splenic injury after trauma: a propensity score analysis
World Journal of Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkurl via IFTTT
Therapeutic effects of Traditional Chinese Medicine on spinal cord injury: a promising supplementary treatment in future
Evidence-based Complementary and Alternative Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUchc via IFTTT
Morphology of the injured posterior wall causing spinal canal encroachment in osteoporotic vertebral fractures
The Spine Journal from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkuri via IFTTT
Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)
Resuscitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUapH via IFTTT
Use of WhatsApp application for Orthopedic Consultations in the ED
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkxDm via IFTTT
The risk of hospital admission due to traumatic brain injury is increased in older persons with severe functional limitations
Journal of the American Medical Directors Association from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUapD via IFTTT
Prevalence and risk factors for central diabetes insipidus in cardiac arrest survivor treated with targeted temperature management
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkuaT via IFTTT
Association between therapeutic hypothermia and long-term quality of life in survivors of cardiac arrest: A systematic review
Resuscitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUapx via IFTTT
{sigma}1-receptor agonism protects against renal ischemia-reperfusion injury
Journal of the American Society of Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkuaQ via IFTTT
Objectively verified parental hip fracture is an independent risk factor for fracture: a linkage analysis of 478,792 parents and 261,705 offspring
Journal of Bone and Mineral Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUbKj via IFTTT
Serious conditions for emergency department elderly fall patients: a secondary analysis of the Basel Nonspecific Complaints study
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROkuaL via IFTTT
Validation of the bacterial meningitis score in adults presenting to the emergency department with meningitis
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The impact of downtime on neurologic intact survival in patients with targeted temperature management after out-of-hospital cardiac arrest: National multicenter cohort study
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Comparison of hybrid fixation versus dual intramedullary nailing fixation for forearm fractures in older children: case-control study
International Journal of Surgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wU9SC via IFTTT
Adding glucose-lowering agents delays insulin initiation and prolongs hyperglycemia
The American Journal of Managed Care from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROktUh via IFTTT
The effectiveness of a newly developed reduction method of anterior shoulder dislocations; Sool’s method
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wUbtN via IFTTT
Shoulder function and bone mineralization in children with obstetric brachial plexus injury after neuromuscular electrical stimulation during weight-bearing exercises
American Journal of Physical Medicine & Rehabilitation from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1ROktUa via IFTTT
The experience of scar management for adults with burns: An interpretative phenomenological analysis
Burns from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/23wU9C4 via IFTTT
Trends in hospital emergency department closures nationwide and across Medicaid expansion, 2006-2013
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Hypoxic hepatitis after out-of-hospital cardiac arrest: incidence, determinants and prognosis
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Pneumatic dilatation for achalasia
Short and medium-term therapeutic effects of pneumatic dilatation for achalasia: a 15-year tertiary centre experience.: Authors: Andreevski V, Nojkov B, Krstevski M, Genadieva Dimitrova M, Joksimovik N, Serafimoski V Abstract BACKGROUND: Pneumatic dilatation (PD) is a commonly used endoscopic technique to weaken the lower oesophageal sphincter in patients with achalasia. It is considered as the most effective non-surgical therapeutic option for achalasia, but further data on the overall effectiveness and rate of complications is needed. AIMS: To determine the short- and medium-ter... περισσότερα »
Supraesophageal reflux disease
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: First page of article]
Training curves for endosurgical interventions in neonates and infants
[Training curves for endosurgical interventions in neonates and infants]. Khirurgiia (Mosk). 2016;(1):44-9 Authors: Kozlov YA, Novozhilov VA, Baradieva PA, Razumovsky AY Abstract AIM: To demonstrate training curves for endosurgical interventions in neonates and infants. MATERIAL AND METHODS: It was analyzed duration of thoracoscopic reconstruction of esophageal atresia (31 patients) and laparoscopic Nissen fundoplication (61 patients) performed for the period from January 2005 to December 2012. Graphs and tables reflecting correlation between duration and number of operations were...περισσότερα »
Nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative
Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the Sun Yat-sen University Cancer Center.: Chin J Cancer. 2016;35(1):37 Authors: Xu BQ, Tu ZW, Tao YL, Liu ZG, Li XH, Yi W, Jiang CB, Xia YF Abstract BACKGROUND: With the improved overall survival (OS) of nasopharyngeal carcinoma (NPC) patients, the importance of quality of life (QoL) is increasingly being recognized. For some radiosensitive NPC patients, whether low-dose radiotherapy can improve the QoL without affecting clinical eff... περισσότερα »
Herpes Esophagitis
Clinical Characteristics and Manifestation of Herpes Esophagitis: One Single-center Experience in Taiwan.: Medicine (Baltimore). 2016 Apr;95(14):e3187 Authors: Wang HW, Kuo CJ, Lin WR, Hsu CM, Ho YP, Lin CJ, Su MY, Chiu CT, Chen KH Abstract We aimed to investigate the clinical characteristics of patients with herpes esophagitis (HE) based on endoscopic typing.Herpes simplex virus infection in the gastrointestinal tract primarily affects the esophagus. However, little is known about the presentation, endoscopic findings, and outcomes of HE.From 2003 to 2013, 47 patients with HE wer...περισσότερα »
The Whole Genome Assembly and Comparative Genomic Research of Thellungiella parvula (Extremophile Crucifer) Mitochondrion
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
The complete nucleotide sequences of the mitochondrial (mt) genome of an extremophile species Thellungiella parvula (T. parvula) have been determined with the lengths of 255,773 bp. T. parvula mt genome is a circular sequence and contains 32 protein-coding genes, 19 tRNA genes, and three ribosomal RNA genes with a 11.5% coding sequence. The base composition of […]
Local cancer survivor shares her story – Aiken Standard
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Aiken Standard Local cancer survivor shares her story Aiken Standard “A doctor determined I had calcium deposits in my largest saliva gland. The deposits were blocking the ducts where saliva drains.” Drinkwater’s specialist then decided it would be best for her to have surgery to remove the upper part of her gland. “I … from […]
Self-management support in patients with adrenal insufficiency
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Abstract Objective Patient education is an important intervention to prevent an adrenal crisis in patients with adrenal insufficiency. The objective of this study was to assess the knowledge of adjusting the dose of glucocorticoids in special circumstances in patients with adrenal insufficiency who had previously been educated on this topic. In patients with insufficient knowledge […]
Incidence of Permanent Hypocalcaemia after Total Thyroidectomy with or without Central Neck Dissection for Thyroid Carcinoma: A Nationwide Claim Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Summary Objective Permanent hypocalcaemia is the most common and serious complication after total thyroidectomy (TT). This study examined the impact of central neck dissection (CND) and institutional volume on rates of permanent hypocalcaemia by analysing data held in the nationwide claim database of South Korea. Design Data from patients who underwent TT due to thyroid […]
The Crabtree and Warburg effects: do metabolite-induced regulations participate in their induction?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Biochimica et Biophysica Acta (BBA) – Bioenergetics Author(s): Noureddine Hammad, Monica Rosas-Lemus, Salvador Uribe-Carvajal, Michel Rigoulet, Anne Devin The Crabtree and Warburg effects are two well-known deviations of cell energy metabolism that will be described herein. A number of hypotheses have been formulated regarding the molecular mechanisms leading […]
Libia: Usa e Nato potrebbero aiutare paese contro espansione Stato Islamico – Agenzia Nova (Abbonamento)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Libia: Usa e Nato potrebbero aiutare paese contro espansione Stato Islamico Agenzia Nova (Abbonamento) Obama ha sottolineato che l’Alleanza atlantica è pronta a fornire il suo sostegno e ha notato i recenti progressi nella formazione di un governo di unità nazionale culminati con l’arrivo a Tripoli del premier incaricato Fayez al Sarraj e dei membri […]
Photoinduced chemiluminescence determination of carbamate pesticides
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C6PP00056H, Paper Monica Catala-Icardo, Susana Meseguer-Lloret, Sagrario Torres-Cartas A liquid chromatography method with post-column photoinduced chemiluminescence (PICL) detection is proposed for the simultaneous determination of eight carbamate pesticides, namely aldicarb, butocarboxim, ethiofencarb, methomyl, methiocarb, thiodicarb, thiofanox and thiophanate-methyl…. The content of this RSS Feed (c) The Royal Society […]
Role of certain amino acid residues of coelenterazine-binding cavity in bioluminescence of light-sensitive Ca2+-regulated photoprotein berovin
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Photochem. Photobiol. Sci., 2016, Accepted Manuscript DOI: 10.1039/C6PP00050A, Paper Ludmila P Burakova, Galina A. Stepanyuk, Elena V. Eremeeva, Eugene S. Vysotski Bright bioluminescence of ctenophores is caused by Ca2+-regulated photoproteins. Although these photoproteins are functionally identical to and share many properties of cnidarian photoproteins, like aequorin and obelin, and retain the… The content of this […]
The first comprehensive report on Indigenous Australian women’s inequalities in cervical screening: A retrospective registry cohort study in Queensland, Australia (2000-2011)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
BACKGROUND The Australian National Cervical Screening Program, introduced more than 20 years ago, does not record the Indigenous status of screening participants. This article reports the first population-based estimates of participation in cervical screening for Indigenous and non-Indigenous Australian women. METHODS This was a retrospective, population-based study of 1,334,795 female Queensland residents, aged 20 to […]
Microvascular Reconstruction of Free Jejunal Graft in Larynx-preserving Esophagectomy for Cervical Esophageal Carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 8 δευτερόλεπτα
Background: Losing the ability to speak severely affects the quality of life, and patients who have undergone laryngectomy tend to become depressed, which may lead to social withdrawal. Recently, with advancements in chemoradiotherapy and with alternative perspectives on postoperative quality of life, larynx preservation has been pursued; however, the selection of candidates and the optimal […]
Primary oropharyngeal herpes simplex virus infection in adults
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: First page of Primary oropharyngeal herpes simplex virus infection in adults: a profile of thirty‐two immunoserologically confirmed cases]
How perceptual contrast sensitivity and perceptual learning cooperate in reducing input variation in speech perception.
[image: http:--content.apa.org-images-shared-Ful] J Exp Psychol Hum Percept Perform. Authors: Sjerps MJ, Reinisch E Abstract Listeners have to overcome variability of the speech signal that can arise, for example, because of differences in room acoustics, differences in speakers' vocal tract properties, or idiosyncrasies in pronunciation. Two mechanisms that are involved in resolving such variation are perceptually contrastive effects that arise from surrounding acoustic context and lexically guided perceptual learning. Although both processes have been studied in great detail, ... περισσότερα »
Mapping of Vocal Risk
in Amateur Choir.: J Voice. 2016 Apr ; Authors: Rosa M, Behlau M Abstract OBJECTIVES: The study aimed to investigate and map the existence of vocal risk in amateur singers, analyzing the contribution of general voice signs and symptoms, specific singing handicap, and generalized anxiety. STUDY DESIGN: This is a cross-sectional study. METHODS: The sample comprised 526 volunteer amateur choristers-186 male and 340 female-(mean age of 42.07 years) from different choirs in the region of São Paulo. Three questionnaires were used: the Voice Symptom Scale (VoiSS), the Modern Singing Ha... περισσότερα »
Symptomatic vallecular cysts
diagnosis and management with the KTP laser.: Eur Arch Otorhinolaryngol. 2016 Apr 7; Authors: Zalvan CH, Reilly E Abstract The objective of this study is to discuss the evaluation and treatment of patients with vallecular cysts removed via potassium titanyl phosphate (KTP) laser therapy. This is a retrospective cohort study with longitundinal follow-up. Clinical records were reviewed for demographic information, symptoms, and findings on laryngoscopy of nine patients having had KTP laser surgery for vallecular cysts. Nine patients (six female, three male) had vallecular cysts remo... περισσότερα »
Voice characteristics and health-related quality of life outcomes following laryngeal cancer treatment with radiotherapy.
A prospective longitudinal study of Acta Oncol. 2016 Apr 8;:1-7 Authors: Karlsson T, Bergström L, Ward E, Finizia C Abstract Background To investigate potential changes in perceptual, acoustic and patient-reported outcomes over 12 months for laryngeal cancer patients treated with radiotherapy. Material and methods A total of 40 patients with Tis-T3 laryngeal cancer treated with curative intent by radiotherapy were included in this prospective longitudinal descriptive study. Patients were followed pre-radiotherapy, one month, six months and 12 months post-radiotherapy, where voice...περισσότερα »
Depressive Disorders in Children with Specific Learning Disabilities
Prevalence of 2016-04-09T15-08-20Z *Source:* Journal of Behavioral Health Mona P Gajre, Himali Meshram,Neelkamal Soares,Ms Chedda Nidhi* Afreddy Anagha*. Abstract Prevalence of Depressive Disorders in Children With Specific Learning Disabilities Background: Learning disabled children are at risk for behavioral disorders, including depression. In India, diagnosis and interventions for learning disorders are limited.The purpose of the present study was to examine the prevalence of depression and its severity in school-aged children with specific learning disability (SLD) comp... περισσότερα »
Optical coherence tomography (OCT) prior to peroral endoscopic myotomy
(POEM) reduces procedural time and bleeding: a multicenter international collaborative study: Abstract BackgroundPer-oral endoscopic myotomy (POEM) has emerged as an endoscopic treatment of achalasia. There are no pre-procedural imaging modalities to predict the safest and the most efficacious approach. AimTo evaluate the use of optimal coherence tomography (OCT) in providing a pre-procedural esophageal assessment. MethodsPatients undergoing POEM from July 2013 to November 2015 were captured in a multicenter, international registry. Patients who underwent OCT pre-POEM (“OC... περισσότερα »
Macrophage activation marker, soluble CD163 is an independent predictor of short-term mortality in patients with cirrhosis and bacterial infection
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Liver International from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Ss5gV1 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VMbQLe via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1qDcYVY via IFTTT
Gut microbiota profiling of pediatric NAFLD and obese patients unveiled by an integrated meta-omics based approach
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1TLMltu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ss5FXj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Nk1kEg via IFTTT
Bioactive peptides in plant-derived foodstuffs
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 11 April 2016 Source:Journal of Proteomics Author(s): Elena Maestri, Marta Marmiroli, Nelson Marmiroli A literature survey covering the presence of bioactive peptides in plant-derived foodstuffs is presented. Examples are given of plant peptides associated with a beneficial effect on human health. The main bioactive effects of these peptides are defined and […]
With or without you — Proteomics with or without major plasma/serum proteins
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 10 April 2016 Source:Journal of Proteomics Author(s): Elisabetta Gianazza, Ingrid Miller, Luca Palazzolo, Chiara Parravicini, Ivano Eberini The first sections of this review compile and discuss strategies and protocols for managing plasma/serum as a source of biomarkers relevant to human disease. In many such cases, depletion of abundant protein(s) is a […]
Could transformation mechanisms of acetylase-harboring pMdT1 plasmid be evaluated through proteomic tools in Escherichia coli?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): P. Magalhães, L. Pinto, A. Gonçalves, E. Araújo, H. Santos, J. Capelo-Martinez, Y. Saénz, M. de Toro, C. Torres, C. Chambon, M. Hebraud, P. Poeta, G. Igrejas Escherichia coli is a commensal microorganism of the gastrointestinal tract of animals and humans and it is […]
Comparative shotgun proteomic analysis of wild and domesticated Opuntia spp. species shows a metabolic adaptation through domestication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): Carole Pichereaux, Eric E. Hernández-Domínguez, Maria del Socorro Santos Diaz, Antonio Reyes-Agüero, Marizel Astello-García, Françoise Guéraud, Anne Negre-Salvayre, Odile Schiltz, Michel Rossignol, Ana Paulina Barba de la Rosa The Opuntia genus is widely distributed in America, but the highest richness of wild species are […]
Role of DAF-21protein in Caenorhabditis elegans immunity against Proteus mirabilis infection
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): Gnanasekaran Jeba Mercy, Sellegounder Durai, Udayakumar Prithika, Shanmugam Marudhupandiyan, Pushpanjali Dasauni, Suman Kundu, Krishnaswamy Balamurugan Caenorhabditis elegans is emerging as one of the handy model for proteome related studies due to its simplest system biology. The present study, deals with changes in protein expression […]
Identification of barley-specific peptide markers that persist in processed foods and are capable of detecting barley contamination by LC-MS/MS
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): Michelle L. Colgrave, Keren Byrne, Malcolm Blundell, Crispin A. Howitt Consumers, especially those with allergies and/or intolerances, should have confidence in two critical areas of food safety: foods should be correctly labelled and free from contamination. To this end, global proteomic analysis employing LC-MS/MS […]
Proteomics in quality control: Whey protein-based supplements
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): Bruno Carius Garrido, Gustavo H.M.F. Souza, Daniela C. Lourenço, Maíra Fasciotti The growing consumption of nutritional supplements might represent a problem, given the concern about the quality of these supplements. One of the most used supplements is whey protein (WP); because of its popularity, […]
Comparative analysis of novel autoantibody isotypes against citrullinated-inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3)542–556 peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren’s syndro me and secondary Sjögren’s syndrome in rheumatoid arthritis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 9 April 2016 Source:Journal of Proteomics Author(s): Chen-Chung Liao, Pei-Lun Chou, Chao-Wen Cheng, Yu-Sheng Chang, Wei-Ming Chi, Kai-Leun Tsai, Wei-Jung Chen, Ting-Shuan Kung, Chih-Chun Tai, Kuan-Wei Lee, You-Chia Chen, Ching-Yu Lin The purpose of this study was to discover and validate inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) as novel biomarkers, and […]
Probable IgG4-related sclerosing disease
presenting as a gastric submucosal tumor with an intense tracer uptake on PET/CT: a case report: AbstractA 44-year-old man consulted an internist because of abnormalities in an upper gastrointestinal series. It showed an elevated lesion with central depression in the greater curvature of the middle part of the stomach. Upper gastrointestinal endoscopy showed an elevated lesion with central depression, bridging hold, and no abnormalities of the gastric mucosa in the greater curvature of the middle part of the stomach. Endoscopic ultrasonography showed a submucosal tumor derived fro... περισσότερα »
MEN1, MEN2, and MEN4
Multiple Endocrine Neoplasia Syndromes via ScienceDirect Publication: Radiologic Clinics of North America Publication date: Available online 10 March 2016 *Source:*Radiologic Clinics of North America Author(s): Joseph R. Grajo, Raj Mohan Paspulati, Dushyant V. Sahani, Avinash Kambadakone TeaserMEN1, MEN2, and MEN4 comprise a series of familial disorders involving the simultaneous occurrence of tumors in more than one endocrine organ, collectively known as multiple endocrine neoplasia. Patients with this family of disorders develop tumors of the parathyroid gland, pancreas, pituitary g...περισσότερα »
Systemic Vasculopathies
Systemic Vasculopathies via ScienceDirect Publication: Radiologic Clinics of North America Publication date: Available online 18 March 2016 *Source:*Radiologic Clinics of North America Author(s): Ankaj Khosla, Brice Andring, Benjamin Atchie, Joseph Zerr, Benjamin White, Jarrod MacFarlane, Sanjeeva P. Kalva TeaserSystemic vasculopathies represent a wide spectrum of heterogeneous vascular disorders characterized by variable target vessel involvement, vascular abnormalities, and end organ damage. The revised 2012 Chapel Hill Consensus Conference scheme classifies systemic vasculitis syndr... περισσότερα »
Multidetector Computed Tomography and MR Imaging Findings in Mycotic Infections
Multidetector Computed Tomography and MR Imaging Findings in Mycotic Infections via ScienceDirect Publication: Radiologic Clinics of North America Publication date: Available online 18 March 2016 *Source:*Radiologic Clinics of North America Author(s): Niranjan Khandelwal, Kushaljit Singh Sodhi, Anindita Sinha, Jyothi G. Reddy, Eshwar N. Chandra TeaserFungal infections constitute a diverse spectrum of infections with variable clinical and imaging features. They are commonly opportunistic infections that affect immunocompromised individuals secondary to inherited or acquired disorders. ... περισσότερα »
„Es fehlen spezielle Programme zur Lebensstiländerung“
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Exzessmortalität bei Schizophrenie Schizophreniepatienten sterben noch immer 20 bis 30 Jahre früher als die übrige Bevölkerung. Das liegt nur zum Teil am ungesunden Lebensstil der Patienten. Der Psychiater Dr. Alkomiet Hasan sieht Defizite in der Diagnostik von Begleiterkrankungen und in der Prävention. Ein Interview. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SZ2s4D via IFTTT Medicine by […]
RA: Zwischen Funktionserhalt und Übertherapie
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Dauerhafte Immunsuppression bei Rheuma Nach Remission einer rheumatoiden Arthritis (RA) unter krankheitsmodifizierenden Therapien (DMARDs) oder Biologika stellt sich über kurz oder lang die Frage, ob eine geringere Dosierung ausreicht und gar ein Absetzen möglich ist. Vorsicht scheint angebracht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UV0ndx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel […]
„Es fehlen spezielle Programme zur Lebensstiländerung“
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Exzessmortalität bei Schizophrenie Schizophreniepatienten sterben noch immer 20 bis 30 Jahre früher als die übrige Bevölkerung. Das liegt nur zum Teil am ungesunden Lebensstil der Patienten. Der Psychiater Dr. Alkomiet Hasan sieht Defizite in der Diagnostik von Begleiterkrankungen und in der Prävention. Ein Interview. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SZ2s4D via IFTTT
RA: Zwischen Funktionserhalt und Übertherapie
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Dauerhafte Immunsuppression bei Rheuma Nach Remission einer rheumatoiden Arthritis (RA) unter krankheitsmodifizierenden Therapien (DMARDs) oder Biologika stellt sich über kurz oder lang die Frage, ob eine geringere Dosierung ausreicht und gar ein Absetzen möglich ist. Vorsicht scheint angebracht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UV0ndx via IFTTT
Statistical considerations on prognostic models for glioma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Given the lack of beneficial treatments in glioma, there is a need for prognostic models for therapeutic decision making and life planning. Recently several studies defining subtypes of glioma have been published. Here, we review the statistical considerations of how to build and validate prognostic models, explain the models presented in the current glioma literature, […]
Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
(Source: Neuro-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WmZAlc via IFTTT
Statistical considerations on prognostic models for glioma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Given the lack of beneficial treatments in glioma, there is a need for prognostic models for therapeutic decision making and life planning. Recently several studies defining subtypes of glioma have been published. Here, we review the statistical considerations of how to build and validate prognostic models, explain the models presented in the current glioma literature, […]
Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Conclusions Our results link CSC-specific niche signaling to a microRNA regulatory network that is altered in glioblastoma and can be targeted to attenuate CSC self-renewal. (Source: Neuro-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Nk04kC via IFTTT
Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
(Source: Neuro-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WmZAlc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Amino acid positron emission tomography to monitor chemotherapy response and predict seizure control and progression-free survival in WHO grade II gliomas
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 21 δευτερόλεπτα
Conclusions Amino acid PET is superior to MRI for evaluating TMZ responses in WHO grade II glioma patients. The response delay between both imaging modalities favors amino acid PET for individually tailoring the duration of chemotherapy. Additional studies should investigate whether this personalized approach is appropriate with regard to outcome. (Source: Neuro-Oncology) from #Medicine-SfakianakisAlexandros via […]
Computed Tomography Angiography
Computed Tomography Angiography via ScienceDirect Publication: Radiologic Clinics of North America Publication date: January 2016 *Source:*Radiologic Clinics of North America, Volume 54, Issue 1 Author(s): Dominik Fleischmann, Anne S. Chin, Lior Molvin, Jia Wang, Richard Hallett TeaserThe principles of computed tomography angiography (CTA) remain the following with modern-day computed tomography (CT): high-resolution volumetric CT data acquisition, imaging at maximum contrast medium enhancement, and subsequent angiographic two- and three-dimensional visualization. One prerequisite for... περισσότερα »
Effect of Nitric Oxide on the Antifungal Activity of Oxidative Stress and Azoles Against Candida albicans
Effect of Nitric Oxide on the Antifungal Activity of Oxidative Stress and Azoles Against Candida albicans: AbstractNitric oxide (NO) is a small molecule with a wide range of biological activities in mammalian and bacteria. However, the role of NO in fungi, especially *Candida albicans*, is not clear. In this study, we confirmed the generation of endogenous NO in *C. albicans*, and found that the production of endogenous NO in *C. albicans* was associated with nitric oxide synthase pathway. Our results further indicated that the production of endogenous NO in *C. albicans* was reduc... περισσότερα »
Core auditory processing deficits in primary progressive aphasia
Core auditory processing deficits in primary progressive aphasia: [image: F1.medium.gif] The extent to which non-linguistic auditory processing deficits may contribute to the phenomenology of primary progressive aphasia is not established. Using non-linguistic stimuli devoid of meaning we assessed three key domains of auditory processing (pitch, timing and timbre) in a consecutive series of 18 patients with primary progressive aphasia (eight with semantic variant, six with non-fluent/agrammatic variant, and four with logopenic variant), as well as 28 age-matched healthy controls... περισσότερα »
The talking language in some major Gram-negative bacteria
The talking language in some major Gram-negative bacteria: AbstractCell–cell interaction or quorum sensing (QS) is a vital biochemical/physiological process in bacteria that is required for various physiological functions, including nutrient uptake, competence development, biofilm formation, sporulation, as well as for toxin secretion. In natural environment, bacteria live in close association with other bacteria and interaction among them is crucial for survival. The QS-regulated gene expression in bacteria is a cell density-dependent process and the initiation process depends on ... περισσότερα »
Nonfunctioning pituitary macroadenoma
a case report from the patient perspective: Background: Nonfunctioning pituitary macroadenoma (NFPA) is a tumour of the endocrine system that is virtually always benign and can be difficult to detect. This case report is presented from the patient’s perspective to highlight experiences that led to the eventual diagnosis of this condition.Case presentationA 48 year-old male experienced prolonged and unexplained reduced athletic performance worsening over five years. The patient reported decreased libido, which initiated a testosterone blood test. This confirmed reduced testosterone ... περισσότερα »
Pulmonary embolism as a complication of an electrophysiological study
: a case report: Background: Electrophysiological studies have become an established practice in the evaluation and treatment of arrhythmias. Symptomatic pulmonary embolism as a result of deep vein thrombosis arising from multiple venous sheath femoral vein catheterization is an uncommon complication associated with it. We report the case of a 33-year-old woman who developed pulmonary embolism after an electrophysiological study, which was successfully treated at a cardiac hospital in Bangladesh.Case presentationA 33-year-old Bangladeshi woman with hypertension and diabetes had init... περισσότερα »
In vivo calibration of esophageal pressure
in the mechanically ventilated patient makes measurements reliable: Background: Esophageal pressure (Pes) can provide information to guide mechanical ventilation in acute respiratory failure. However, both relative changes and absolute values of Pes can be affected by inappropriate filling of the esophageal balloon and by the elastance of the esophagus wall. We evaluated the feasibility and effectiveness of a calibration procedure consisting in optimization of balloon filling and subtraction of the pressure generated by the esophagus wall (Pew). Methods: An esophageal balloon was... περισσότερα »
Endocrine-cerebro-osteodysplasia (ECO) syndrome
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome: Background: Endocrine-cerebro-osteodysplasia (ECO) syndrome [MIM:612651] caused by a recessive mutation (p.R272Q) in Intestinal cell kinase (ICK) shows significant clinical overlap with ciliary disorders. Similarities are strongest between ECO syndrome, the Majewski and Mohr-Majewski short-rib thoracic dysplasia (SRTD) with polydactyly syndromes, and hydrolethalus syndrome. In this study, we present a novel homozygous ICK mutation in a fetus with ECO syndrome and compare the effect o... περισσότερα »
Child maltreatment and pediatric asthma
a review of the literature: Background: Child maltreatment is a common problem with known adverse consequences, yet its contributions to the development and course of pediatric asthma are only poorly understood.MainThis review first describes possible pathways connecting child maltreatment to pediatric asthma, including aspects of the physical home environment, health behaviors and disease management, and psychological consequences of child maltreatment. We subsequently review existing studies, which generally report an association between maltreatment experiences and asthma outcom...περισσότερα »
Allergic reactions to milk appear sooner than reactions to hen’s eggs
a retrospective study: Background: Oral food challenge test doses are recommended to be performed at least 20 min apart; however, the times of symptom provocation from the start of the oral food challenge have never been compared between different foods. In this study, the durations from the start of the oral food challenge to symptom development in children with egg or milk allergy were compared. Methods: Thirty-eight and 74 children who had previously passed oral food challenges to 96 g of yogurt and pumpkin cake containing ¼ whole egg underwent oral food challenges with 200 mL r... περισσότερα »
Severity and disease control before house dust mite immunotherapy initiation
ANTARES a French observational survey: Background: Allergen immunotherapy (AIT) may be prescribed for patients with allergic rhinitis (AR) induced by house dust mites (HDM) whether asthma is present or not. Current guidelines provide insufficient support for therapeutic management strategy of these patients. Allergists however have long-term experience with AIT. This study aims to describe the characteristics of the patients seen in clinical practice with HDM allergy and the process used to determine whether AIT should be initiated. Methods: This was an observational, multicenter,... περισσότερα »
Cleaning and disinfection of environmental surfaces
Modern technologies for improving cleaning and disinfection of environmental surfaces in hospitals: Experts agree that careful cleaning and disinfection of environmental surfaces are essential elements of effective infection prevention programs. However, traditional manual cleaning and disinfection practices in hospitals are often suboptimal. This is often due in part to a variety of personnel issues that many Environmental Services departments encounter. Failure to follow manufacturer’s recommendations for disinfectant use and lack of antimicrobial activity of some disinfectants ag... περισσότερα »
Atypical antipsychotic medications and hyponatremia
in older adults: a population-based cohort study: Background: A number of case reports have suggested a possible association between atypical antipsychotic medications and hyponatremia. Currently, there are no reliable estimates of hyponatremia risk from atypical antipsychotic drugs.ObjectiveThe objective of this study was to examine the 30-day risk of hospitalization with hyponatremia in older adults dispensed an atypical antipsychotic drug relative to no antipsychotic use.DesignThe design of this study was a retrospective, population-based cohort study.SettingThe setting of this ...περισσότερα »
Inappropriate Prescribing (STRIP) in adults with an intellectual disability
Medication review using a Systematic Tool to Reduce Inappropriate Prescribing (STRIP) in adults with an intellectual disability: A pilot study via ScienceDirect Publication: Research in Developmental Disabilities Publication date: August 2016 *Source:*Research in Developmental Disabilities, Volume 55 Author(s): Rianne J. Zaal, Susan Ebbers, Mirka Borms, Bart de Koning, Erna Mombarg, Piet Ooms, Hans Vollaard, Patricia M.L.A. van den Bemt, Heleen M. Evenhuis A Systematic Tool to Reduce Inappropriate Prescribing (STRIP), which includes the Screening Tool to Alert doctors to Right Treatment...περισσότερα »
Different Levels of DNA Methylation Detected in Human Sperms after Morphological Selection Using High Magnification Microscopy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Objective. To analyze DNA methylation levels between two groups of spermatozoa taken from the same sample, following morphological selection by high magnification (HM) at 6100x microscopy. A prospective study was conducted and studied 876 spermatozoa from 10 randomly selected men. Sperm morphology was characterized at HM according to criteria previously established. High-scoring Score 6 and […]
A Protection Mechanism against Malicious HTML and JavaScript Code in Vulnerable Web Applications
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
The high-profile attacks of malicious HTML and JavaScript code have seen a dramatic increase in both awareness and exploitation in recent years. Unfortunately, exiting security mechanisms provide no enough protection. We propose a new protection mechanism named PMHJ based on the support of both web applications and web browsers against malicious HTML and JavaScript code […]
ELDP: Extended Link Duration Prediction Model for Vehicular Networks
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
Link duration between two vehicles is considered an important quality of service metric in designing a network protocol for vehicular networks. There exist many works that study the probability density functions of link duration in a vehicular network given various vehicle mobility models, for example, the random waypoint model. None of them, however, provides a […]
PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear receptor superfamily. Upon ligand binding, PPARs activate target gene transcription and regulate a variety of important physiological processes such as lipid metabolism, inflammation, and wound healing. Here, we describe the first database of PPAR target genes, PPARgene. Among the 225 experimentally verified PPAR […]
Hydrogen Sulfide: Biogenesis, Physiology, and Pathology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TLSRR9 via IFTTT
Sorption Profile of Phosphorus Ions onto ZnO Nanorods Synthesized via Sonic Technique
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 29 δευτερόλεπτα
High surface area zinc oxide material in nanorod morphological structure was synthesized using an ultrasonic technique in the presence of polyvinyl pyrrolidone as stabilizing agent. The crystallite, morphology, and surface area of the prepared white powder material were identified using XRD, SEM, and BET techniques, respectively. X-ray analysis confirms the high purity of synthesized ZnO. […]
Selenium and Vitamin E together improve intestinal epithelial barrier function
and alleviate oxidative stress in heat stressed pigs: Heat stress compromises intestinal epithelial barrier integrity of mammals through mechanisms that may include oxidative stress. Our objective was to test whether dietary supplementation with antioxidants, selenium (Se) and Vitamin E (VE), protects intestinal epithelial barrier integrity in heat stressed pigs. Female growing pigs (n = 48) were randomly assigned to four diets containing from 0.2 ppm Se and 17 IU kg−1 VE (control, NRC recommended), to 1.0 ppm Se and 200 IU kg−1 VE for 14 days. Six pigs from each dietary treatment... περισσότερα »
Spontaneous fracture and migration of catheter
of a totally implantable venous access port via internal jugular vein - a case report: Background: The totally implantable venous access ports (TIVAPs) are indicated for patients undergoing chemotherapy, total parenteral nutrition and long-term antibiotic treatment. But, among their complications, the fracture and migration of the catheter of a TIVAP via internal jugular vein represents a very rare but potentially severe condition.Case presentationA 50-year-old woman indentified with a spontaneous fracture and migration of catheter of a TIVAP via right internal jugular vein after a... περισσότερα »
Integrated slice-by-slice shimming (iShim) for improving the image quality of whole-body diffusion-weighted imaging (WBDWI)
Integrated Shimming Improves Lesion Detection in Whole-Body Diffusion-Weighted Examinations of Patients With Plasma Disorder at 3 T: Objective: The purpose of this study was to evaluate the feasibility of using integrated slice-by-slice shimming (iShim) for improving the image quality of whole-body diffusion-weighted imaging (WBDWI) in patients with plasma disorder at 3 T by comparing to WBDWI using a conventional shimming (3-dimensional [3D] shim) adjustment of each body station. Materials and Methods: After approval by the local institutional review board, 2 healthy volunteers and...περισσότερα »
Safety of the Gadolinium-Based Contrast Agents for MRI
Focusing in Part on Their Accumulation in the Brain and Especially the Dentate Nucleus: Abstract: The established class of intravenous contrast media for magnetic resonance imaging is the gadolinium chelates, more generally referred to as the gadolinium-based contrast agents (GBCAs). These can be differentiated on the basis of stability in vivo, with safety and tolerability of the GBCAs dependent upon chemical and biologic inertness. This review discusses first the background in terms of development of these agents and safety discussions therein, and second their relative stability ... περισσότερα »
High Levels of Gadolinium Deposition in the Skin
of a Patient With Normal Renal Function: Objective: The aim of this study was to assess gadolinium deposition in the skin of a patient with normal renal function, based on estimated glomerular filtration rate values greater than 59 mL/min/1.73 m2 after exposure to large cumulative doses of gadolinium-based contrast agents (GBCAs). Materials and Methods: The patient underwent 61 contrasted brain MRI scans over the course of 11 years. Skin biopsies from the forearm and lower extremity were analyzed with inductively coupled plasma mass spectrometry (ICP-MS), laser ablation ICP-MS, and... περισσότερα »
Point of Care Testing for the Diagnosis of Fungal Infections
Are We There Yet?: AbstractDiagnostic tools for invasive fungal infections have continuously improved within the last decades. Nowadays, cultural methods, antigen testing, and molecular tests, such as polymerase chain reaction, are widely used. These methods, however, are accompanied with different limitations as various availability, various turnaround time or high costs. A new generation of point-of-care test has shown promising results in various studies and may overcome some of these limitations. We therefore reviewed the literature for the most promising new point-of-care tes... περισσότερα »
Protocollo Gestionale Diagnostico-Terapeutico-Assistenziale, PDTA
Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB): Abstract PurposeThe diagnostic, therapeutic and health-care management protocol (Protocollo Gestionale Diagnostico-Terapeutico-Assistenziale, PDTA) by the Association of the Italian Endocrine Surgery Units (U.E.C. CLUB) aims to help treat the patient in a topical, rational way that can be shared by health-care professionals. MethodsThis fourth consensus conference involved: a selected group of experts in the p...περισσότερα »
Biases in grant proposal success rates, funding rates and award sizes affect the geographical distribution of funding for biomedical research
[image: fig-1-1x.jpg] The ability of the United States to most efficiently make breakthroughs on the biology, diagnosis and treatment of human diseases requires that physicians and scientists in each state have equal access to federal research grants and grant dollars. However, despite legislative and administrative efforts to ensure equal access, the majority of funding for biomedical research is concentrated in a minority of states. To gain insight into the causes of such disparity, funding metrics were examined for all NIH research project grants (RPGs) from 2004 to 2013. State... περισσότερα »
Distributions of p-values smaller than .05 in psychology: what is going on?
[image: fig-1-1x.jpg] Previous studies provided mixed findings on pecularities in p-value distributions in psychology. This paper examined 258,050 test results across 30,710 articles from eight high impact journals to investigate the existence of a peculiar prevalence of p-values just below .05 (i.e., a bump) in the psychological literature, and a potential increase thereof over time. We indeed found evidence for a bump just below .05 in the distribution of exactly reported p-values in the journals Developmental Psychology, Journal of Applied Psychology, and Journal of Personality ... περισσότερα »
How we see electronic games
[image: fig-1-1x.jpg] Theories regarding the influences of electronic games drive scientific study, popular debate, and public policy. The fractious interchanges among parents, pundits, and scholars hint at the rich phenomenological and psychological dynamics that underlie how people view digital technologies such as games. The current research applied Martin Heidegger's concept of interpretive frameworks (Heidegger, 1987) and Robert Zajonc's exposure-attitude hypothesis (Zajonc, 1968) to explore how attitudes towards technologies such as electronic games arise. Three studies drew ...περισσότερα »
Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro
[image: fig-1-1x.jpg] It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN). Here we used shRNA transfection to knockdown the insulin receptor (IR) gene in cultured human immortalized podocytes as an in vitro insulin resistant model. Autophagy related proteins LC3, Beclin, and p62 as well as nephrin, a podocyte injury marker, were assessed using western blot and immunofluorescence staining. Our results show that autophagy is suppressed when podocytes lose insulin sensitivi...περισσότερα »
Involvement of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and invasion of human multiple myeloma cells
[image: fig-1-1x.jpg] Cytochrome P450 (CYP) epoxygenases and the metabolites epoxyeicosatrienoic acids (EETs) exert multiple biological effects in various malignancies. We have previously found EETs to be secreted by multiple myeloma (MM) cells and to be involved in MM angiogenesis, but the role of the arachidonic acid cytochrome P450 epoxygenase pathway in the proliferation and mobility of MM cells remains unknown. In the present study, we found that MM cell lines generated detectable levels of 11,12-EET/14,15-EET and that increased levels of EETs were found in the serum of MM pat...περισσότερα »
Connecting laboratory behavior to field function through stable isotope analysis
[image: fig-1-1x.jpg] Inherent difficulties of tracking and observing organisms in the field often leave researchers with no choice but to conduct behavioral experiments under laboratory settings. However, results of laboratory experiments do not always translate accurately to natural conditions. A fundamental challenge in ecology is therefore to scale up from small area and short-duration laboratory experiments to large areas and long durations over which ecological processes generally operate. In this study, we propose that stable isotope analysis may be a tool that can link labo... περισσότερα »
Differences in stability of seed-associated microbial assemblages in response to invasion by phytopathogenic microorganisms
[image: fig-1-1x.jpg] Seeds are involved in the vertical transmission of microorganisms from one plant generation to another and consequently act as reservoirs for the plant microbiota. However, little is known about the structure of seed-associated microbial assemblages and the regulators of assemblage structure. In this work, we have assessed the response of seed-associated microbial assemblages of Raphanus sativus to invading phytopathogenic agents, the bacterial strain Xanthomonas campestris pv. campestris (Xcc) 8004 and the fungal strain Alternaria brassicicola Abra43. Accordi...περισσότερα »
ROCK activity regulates functional tight junction assembly during blastocyst formation in porcine parthenogenetic embryos
[image: fig-1-1x.jpg] The Rho-associated coiled-coil-containing protein serine/threonine kinases 1 and 2 (ROCK1 and ROCK2) are Rho subfamily GTPase downstream effectors that regulate cell migration, intercellular adhesion, cell polarity, and cell proliferation by stimulating actin cytoskeleton reorganization. Inhibition of ROCK proteins affects specification of the trophectoderm (TE) and inner cell mass (ICM) lineages, compaction, and blastocyst cavitation. However, the molecules involved in blastocyst formation are not known. Here, we examined developmental competence and levels o... περισσότερα »
Assessment of the accuracy of ABC/2 variations in traumatic epidural hematoma volume estimation: a retrospective study
[image: fig-1-1x.jpg] Background. The traumatic epidural hematoma (tEDH) volume is often used to assist in tEDH treatment planning and outcome prediction. ABC/2 is a well-accepted volume estimation method that can be used for tEDH volume estimation. Previous studies have proposed different variations of ABC/2; however, it is unclear which variation will provide a higher accuracy. Given the promising clinical contribution of accurate tEDH volume estimations, we sought to assess the accuracy of several ABC/2 variations in tEDH volume estimation. Methods. The study group comprised 53 ... περισσότερα »
Effects of combined physical education and nutritional programs on schoolchildren’s healthy habits
[image: fig-1-1x.jpg] Background. A multidisciplinary approach seems to be effective in creating healthy habits in children. The aim of this study was to evaluate the efficacy of three 5-month combined physical education (PE) and nutritional interventions on body composition, physical activity (PA) level, sedentary time and eating habits of schoolchildren. Methods. Anthropometric data, weekly PA level, sedentary time and eating habits of 230 healthy students were analysed using a repeated-measures ANOVA with Group (experimental group 1 vs experimental group 2 vs control group), Adi... περισσότερα »
Diagnostic, therapeutic and health-care management protocol in thyroid surgery
a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB): Abstract PurposeThe diagnostic, therapeutic and health-care management protocol (Protocollo Gestionale Diagnostico-Terapeutico-Assistenziale, PDTA) by the Association of the Italian Endocrine Surgery Units (U.E.C. CLUB) aims to help treat the patient in a topical, rational way that can be shared by health-care professionals. MethodsThis fourth consensus conference involved: a selected group of experts in the preliminary phase; all members, via e-mail, in the elaboration phase; all the par... περισσότερα »
Post-traumatic Aneurysm of the Internal Carotid Artery
Post-traumatic Aneurysm of the Left Internal Carotid Artery via ScienceDirect Publication: European Journal of Vascular and Endovascular Surgery Publication date: Available online 10 April 2016 [image: Image for unlabelled figure] *Source:*European Journal of Vascular and Endovascular Surgery Author(s): S.H. Koter, T.U. Cohnert
Permanent Hypocalcaemia after Total Thyroidectomy
Incidence of Permanent Hypocalcaemia after Total Thyroidectomy with or without Central Neck Dissection for Thyroid Carcinoma: A Nationwide Claim Study: Summary Objective Permanent hypocalcaemia is the most common and serious complication after total thyroidectomy (TT). This study examined the impact of central neck dissection (CND) and institutional volume on rates of permanent hypocalcaemia by analysing data held in the nationwide claim database of South Korea. Design Data from patients who underwent TT due to thyroid carcinoma from 2007–2013 were obtained from the Health Insuranc... περισσότερα »
Therapeutic Implications of Melanoma Heterogeneity
Therapeutic Implications of Melanoma Heterogeneity: Abstract Over the last decade, the treatment of metastatic melanoma has been revolutionized by the translation of molecular insights into therapeutic benefit for patients. These include advances in immune-therapeutic and small molecule approaches aimed at destroying cells with immunogenic antigens or gene mutations. Despite these advances, the limited durability of clinical response and eventual disease progression underscores a need for better understanding of mechanisms underlying tumor development. Current targeted therapies ar... περισσότερα »
Lymphomatosis cerebri
a rare form of primary central nervous system lymphoma. Analysis of 7 cases and systematic review of the literature: Background Primary central nervous system lymphomas may present as diffuse, nonenhancing infiltrative lesions. This rare variant is termed lymphomatosis cerebri (LC). We did a systematic review and analysis of the literature, adding our own cases, to better characterize LC in order to improve early diagnosis and treatment. Methods PubMed, ISI Web of Knowledge, and hospital databases were reviewed. Information was extracted regarding demographic, clinical, histologic...περισσότερα »
Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma
Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma: Background Meningiomas are the most common primary intracranial tumor in adults. Identification of *SMO* and *AKT1* mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutations in meningiomas are important to define. Methods We used high-resolution array-comparative genomic hybridization to prospectively characterize copy-number changes in 150 meningiomas and then character...περισσότερα »
Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are tumor-suppressor syndromes
Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis: Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are tumor-suppressor syndromes. Each syndrome is an orphan disease; however, the tumors that arise within them represent the most common tumors of the nervous system worldwide. Systematic investigation of the pathways impacted by the loss of function of neurofibromin (encoded by *NF1*) and merlin (encoded by *NF2*) have led to therapeutic advances for patients with NF1 and NF2. In the syn... περισσότερα »
Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis
Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis: Neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN) are tumor-suppressor syndromes. Each syndrome is an orphan disease; however, the tumors that arise within them represent the most common tumors of the nervous system worldwide. Systematic investigation of the pathways impacted by the loss of function of neurofibromin (encoded by *NF1*) and merlin (encoded by *NF2*) have led to therapeutic advances for patients with NF1 and NF2. In the syn... περισσότερα »
Neuropilin-2 promotes tumorigenicity and metastasis in ESCC
through ERK MAPK/ETV4/MMP/E-cadherin deregulation: [image: cover.gif?v=1&s=1ea0300be86d7bfbd699656c] Abstract Esophageal squamous cell carcinoma (ESCC) is the most common histologic subtype of esophageal cancer. The disease is particularly prevalent in Southern China. The incidence of the disease is on the rise and its overall survival rate remains dismal. Identification and characterization of better molecular markers for early detection and therapeutic targeting are urgently needed. Here, we report levels of transmembrane and soluble neuropilin-2 (NRP2) to be significantly up... περισσότερα »
Allergic reactions to milk appear sooner than reactions to hen’s eggs
: a retrospective study: Abstract Background Oral food challenge test doses are recommended to be performed at least 20 min apart; however, the times of symptom provocation from the start of the oral food challenge have never been compared between different foods. In this study, the durations from the start of the oral food challenge to symptom development in children with egg or milk allergy were compared. Methods Thirty-eight and 74 children who had previously passed oral food challenges to 96 g of yogurt and pumpkin cake containing ¼ whole egg underwent oral food challenges wit... περισσότερα »
Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed type hypersensitivity
Production of endocannabinoids by activated T cells and B cells modulates inflammation associated with delayed type hypersensitivity: Endocannabinoids are endogenous ligands for the cannabinoid (CB) receptors which include anandamide (AEA) and 2-arachidonyl glycerol (2-AG). 2-AG has been linked to inflammation due to its elevated expression in animal models of autoimmunity and hypersensitivity. However, administration of exogenous 2-AG has been shown to suppress inflammation making its precise role unclear. In the current study, we investigated the role of 2-AG following immunizati...περισσότερα »
The Lesser Occipital Nerve
Anatomic and Compression Topography of [image: image]Background: The surgical treatment of occipital headaches focuses on the greater, lesser, and third occipital nerves. The lesser occipital nerve (LON) is usually transected with relatively limited available information regarding the compression topography thereof and how such knowledge may impact surgical treatment. Methods: Eight fresh frozen cadavers were dissected focusing on the LON in relation to 3 clinically relevant compression zones. The x axis was a line drawn through the occipital protuberance (OP) and the y axis, t...περισσότερα »
Pericardial Metastasis Induced Tamponade from Urothelial Carcinoma: A Rare Entity
Urothelial carcinoma in a few cases may result in cardiac metastasis. A rare presentation of this condition is its diagnosis as a result of cardiac tamponade. Tamponade is an unusual entity as a result of urothelial carcinoma and has only been reported in four cases. There have also been only a total of fifteen cases of cardiac metastasis from this form of malignancy. It is through this discussion that we emphasize the importance of early detection and monitoring of cardiac symptoms with the implementation of echocardiogram imaging. Although not feasible in all patients it may be ... περισσότερα »
WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
Copy number variations (CNVs) have attracted increasing evidences to represent their roles as cancer susceptibility regulators. However, little is known about the role of CNV in epithelia ovarian cancer (EOC). Recently, the CNV-67048 of WW domain-containing oxidoreductase (WWOX) was reported to alter cancer risks. Considering that WWOX also plays a role in EOC, we hypothesized that the CNV-67048 was associated with EOC risk. In a case-control study of 549 EOC patients and 571 age (±5 years) matched cancer-free controls, we found that the low copy number of CNV-67048 (1-copy and 0-... περισσότερα »
Phenotypic Variation in Patients with Chronic Obstructive Pulmonary Disease in Primary Care
Introduction. Despite the high number of inactive patients with COPD, not all inactive patients are referred to physical therapy, unlike recommendations of general practitioner (GP) guidelines. It is likely that GPs take other factors into account, determining a subpopulation that is treated by a physical therapist (PT). The aim of this study is to explore the phenotypic differences between inactive patients treated in GP practice and inactive patients treated in GP practice combined with PT. Additionally this study provides an overview of the phenotype of patients with COPD in PT... περισσότερα »
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