Pediatric meningioma recurrence
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Prediction of pediatric meningioma recurrence by preoperative MRI assessment via Latest Results for Neurosurgical Review Abstract Preoperative identification of high-recurrent pediatric meningiomas with MRI features would help clinicians to make optimal treatment strategies; however, the relationships between radiological features and recurrence of meningiomas in pediatric population have not been clearly demonstrated yet. The aim of […]
The use of spine stereotactic radiosurgery for oligometastatic disease
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
The use of spine stereotactic radiosurgery for oligometastatic disease: Journal of Neurosurgery: Spine, Ahead of Print. OBJECTIVE The authors investigated the outcomes following spine stereotactic radiosurgery (SSRS) for patients with oligometastatic disease of the spine. METHODS The study was a secondary analysis of 38 of 209 patients enrolled in 2 separate institutional Phase I/II prospective […]
Risk factors for surgical site infection in cranial neurosurgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Implementation of a care bundle and evaluation of via Clinical Neurology and Neurosurgery Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Benjamin M. Davies, Anna Jones, Hiren C. Patel ObjectivesSurgical site infection [SSI] increases mortality, morbidity and length of hospital stay. Peri-operative ‘care bundles’ have reduced SSI in some fields of surgery. […]
Microneurosurgery and subsequent gamma knife radiosurgery for functioning pituitary macroadenomas or giant adenomas
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
: one institution’s experience via Clinical Neurology and Neurosurgery Publication date: Available online 2 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): Peng Fu, Yun-song He, Yong-cun Cen, Qin Huang, Ke-tai Guo, Hong-yang Zhao, Wei Xiang ObjectiveFunctioning pituitary macroadenoma and giant adenoma have large growth volumes and endocrinological abnormalities, requiring proper medical intervention. In this retrospective […]
Foramen Magnum Meningioma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
: the midline suboccipital subtonsillar approach via Clinical Neurology and Neurosurgery Publication date: Available online 2 April 2016 Source:Clinical Neurology and Neurosurgery Author(s): S. Dobrowolski, F. Ebner, G. Lepski, M. Tatagiba ObjectivesForamen magnum meningiomas (FMMs) represent a technical challenge even for experienced neurosurgeons, because they grow in close contact with osteoarticular, nervous, and vascular structures […]
Human papillomavirus vaccinations : Recurrent optic neuritis and neuromyelitis optica-IgG
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
following first and second human papillomavirus vaccinations via Clinical Neurology and Neurosurgery Publication date: May 2016 Source:Clinical Neurology and Neurosurgery, Volume 144 Author(s): Hyeyeon Chang, Hye Lim Lee, Minju Yeo, Ji Seon Kim, Dong-Ick Shin, Sang-Soo Lee, Sung-Hyun Lee Human papillomavirus (HPV) vaccine is widely used to prevent cervical cancer caused by certain types of […]
Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery: Abstract Purpose Computer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of the surgical instruments. Instrument tracking is a challenging problem in both conventional and robotic-assisted MIS, but vision-based approaches are a promising solution with minimal hardware integration requirements. However, […]
Robotic surgery training
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
: construct validity of Global Evaluative Assessment of Robotic Skills (GEARS): Abstract The objective of this study is to determine the ability of the GEARS scale (Global Evaluative Assessment of Robotic Skills) to differentiate individuals with different levels of experience in robotic surgery, as a fundamental validation. This is a cross-sectional study that included three […]
Transclival injury after routine transnasal rhinological surgery
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
Transclival injury after routine transnasal rhinological surgery via Clinical Neurology and Neurosurgery Publication date: June 2016 Source:Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of […]
Blood pressure lowering does not reduce risk of cardiovascular events in patients at intermediate risk
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 λεπτό
from Uncategorized via xlomafota13 on Inoreader http://ift.tt/1MNtEEi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RX0MeQ via IFTTT
Endoscope-assisted retrosigmoid infralabyrinthine approach to jugular foramen tumors
Endoscope-assisted retrosigmoid infralabyrinthine approach to jugular foramen tumors: Journal of Neurosurgery, Volume 124, Issue 4, Page 1061-1067, April 2016. OBJECT Removal of jugular foramen (JF) tumors usually requires extensive skull base approaches and is frequently associated with postoperative morbidities such as lower cranial nerve injury. The endoscope-assisted retrosigmoid infralabyrinthine approach is a relatively new approach to tumors extending into the bony canal of the JF. The authors present their experience with this approach. METHODS The endoscope-assisted retros...περισσότερα »
Gamma Knife versus linear accelerator-based stereotactic radiosurgery for brain metastases
Changing practice patterns of Gamma Knife versus linear accelerator-based stereotactic radiosurgery for brain metastases in the US: Journal of Neurosurgery, Volume 124, Issue 4, Page 1018-1024, April 2016. OBJECT Single-fraction stereotactic radiosurgery (SRS) is a crucial component in the management of limited brain metastases from non-small cell lung cancer (NSCLC). Intracranial SRS has traditionally been delivered using a frame-based Gamma Knife (GK) platform, but stereotactic modifications to the linear accelerator (LINAC) have made an alternative approach possible. In the abse...περισσότερα »
Cranial neuropathy after flow diversion for carotid aneurysms
The fate of Journal of Neurosurgery, Volume 124, Issue 4, Page 1107-1113, April 2016. OBJECT The authors sought to determine whether flow diversion with the Pipeline Embolization Device (PED) can approximate microsurgical decompression in restoring function after cranial neuropathy following carotid artery aneurysms. METHODS This multiinstitutional retrospective study involved 45 patients treated with PED across the United States. All patients included presented between November 2009 and October 2013 with cranial neuropathy (cranial nerves [CNs] II, III, IV, and VI) due to intrac... περισσότερα »
Real-time MRI-guided frameless stereotactic brain biopsy
: technical note: Journal of Neurosurgery, Volume 124, Issue 4, Page 1039-1046, April 2016. OBJECT The object of this study was to assess the feasibility, accuracy, and safety of real-time MRI-compatible frameless stereotactic brain biopsy. METHODS Clinical, imaging, and histological data in consecutive patients who underwent stereotactic brain biopsy using a frameless real-time MRI system were analyzed. RESULTS Five consecutive patients (4 males, 1 female) were included in this study. The mean age at biopsy was 45.8 years (range 29–60 years). Real-time MRI permitted concurrent dis...περισσότερα »
Is jugular bulb stenosis in vein of Galen aneurysmal malformation associated with bony remodeling of the jugular foramina?
Is jugular bulb stenosis in vein of Galen aneurysmal malformation associated with bony remodeling of the jugular foramina?: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The etiology of jugular bulb stenosis (JBS) or occlusion in the context of vein of Galen aneurysmal malformations (VGAMs) is unknown. It can lead to decompensation of a lesion that was previously clinically stable. The aim of this study was to describe the natural history of JBS or occlusion in VGAM and to determine whether there is an association with bony remodeling of the jugular foramina. METHO... περισσότερα »
Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis
Differential spatial regulation of BMP molecules is associated with single-suture craniosynostosis: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The aim of this study was to examine messenger RNA (mRNA) levels of bone morphogenetic protein (BMP) ligands, receptors, and soluble inhibitors in cells isolated from single-suture synostoses from fused coronal, metopic, sagittal, and lambdoid sutures. METHODS Cells were isolated from bone collected from patients undergoing craniotomies at Children's Healthcare of Atlanta. Real-time polymerase chain reaction was used to ...περισσότερα »
The manic phase of Bipolar disorder significantly impairs theory of mind decoding.
*The manic phase of Bipolar disorder significantly impairs theory of mind decoding.* Psychiatry Res. 2016 Mar 29;239:275-280 Authors: Hawken ER, Harkness KL, Lazowski LK, Summers D, Khoja N, Gregory JG, Milev R Abstract Bipolar disorder is associated with significant deficits in the decoding of others' mental states in comparison to healthy participants. However, differences in theory of mind decoding ability among patients in manic, depressed, and euthymic phases of bipolar disorder is currently unknown. Fifty-nine patients with bipolar I or II disorder (13 manic, 25 depressed, ... περισσότερα »
Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States.
*Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States.* Psychiatry Res. 2016 Mar 25;239:253-258 Authors: Bernardini F, Lunden A, Covington M, Broussard B, Halpern B, Alolayan Y, Crisafio A, Pauselli L, Balducci PM, Capulong L, Attademo L, Lucarini E, Salierno G, Natalicchi L, Quartesan R, Compton MT Abstract This is the first cross-language study of the effect of schizophrenia on speech as measured by analyzing phonetic parameters with sound spectrograph... περισσότερα »
A Novel Approach to the Challenging Injection Laryngoplasty
Introduction: Injection laryngoplasty (IL) is typically performed either awake or under general anesthesia with paralysis. There is a subgroup of patients, however, for whom neither of these is a good option. For such patients, we report a hybrid technique that allows for a percutaneous injection without paralysis but with sedation to increase patient tolerance. Supraglottic airway laryngotracheal intervention (SALTI) brings the benefits of injection laryngoplasty to a group of patients previously underserved. Methods: Injection laryngoplasty cases using SALTI technique from Jul... περισσότερα »
Surgeon Awareness of Operating Room Supply Costs
Background: The extent to which surgeons understand costs associated with expensive operative procedures remains unclear. The goal of the study was to better understand surgeon cost awareness of operating room supplies and implants. Methods: This was a cross-sectional study of faculty (n = 24) and trainees (fellow and residents, n = 27) in the Department of Otolaryngology. Participants completed surveys to assess opinions on importance of cost and ease in accessing cost data and were asked to estimate the costs of operating room (OR) supplies and implants. Estimates within 20% o...περισσότερα »
Audioprofile Surfaces: The 21st Century Audiogram
Objective: To present audiometric data in 3 dimensions by considering age as an addition dimension. Methods: Audioprofile surfaces (APSs) were fitted to a set of audiograms by plotting each measurement of an audiogram as an independent point in 3 dimensions with the x, y, and z axes representing frequency, hearing loss in dB, and age, respectively. Results: Using the Java-based APS viewer as a standalone application, APSs were pre-computed for 34 loci. By selecting APSs for the appropriate genetic locus, a clinician can compare this APS-generated average surface to a specific... περισσότερα »
Revisiting Place-Pitch Match in CI Recipients Using 3D Imaging Analysis
Objective: To improve the estimation of the perceived pitch in a single-sided deaf cochlear implant (CI) listener by using accurate 3-dimensional (3D) image analysis of the cochlear electrode positions together with the predicted tonotopical function for humans. Methods: An SSD CI user underwent a Cone-Beam computed tomography (CBCT) scan. Electrode contacts were marked in 3D space in relation to the nearest point on the cochlear lateral wall. Distance to the base of the lateral wall was calculated and plotted against the place-pitch function for humans. An adaptive procedure w... περισσότερα »
Early Cellular Response to Radiation in Human Vocal Fold Fibroblasts
Objectives: Radiation therapy is a common treatment strategy for laryngeal carcinoma. However, radiation is not without adverse side effects, especially toward healthy vocal fold tissue, which can lead to long-term impairments in vocal function. The objective of this preliminary study was to investigate early responses of healthy human vocal fold fibroblasts (VFF) to radiation. Methods: VFF were exposed to a single or fractionated dose radiation scheme. Nonradiated VFF served as controls. Morphology of radiated and control VFF was subjectively examined. Quantitative polymerase c... περισσότερα »
Quantitative Measures of Swallowing Deficits in Patients With Parkinsons Disease
Objective: Dysphagia and associated aspiration pneumonia are commonly reported sequelae of Parkinson's disease (PD). Previous studies of swallowing in patients with PD have described prolonged pharyngeal transit time, delayed onset of pharyngeal transit, cricopharyngeal (CP) achalasia, reduced pharyngeal constriction, and slowed hyolaryngeal elevation. These studies were completed using inconsistent evaluation methodology, reliance on qualitative analysis, and a lack of a large control group, resulting in concerns regarding diagnostic precision. The purpose of this study was to ... περισσότερα »
A Controlled, Randomized Clinical Study on the Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty
Objectives: To find out the effect of minimal invasive sinus surgery and balloon sinuplasty on mucociliary clearance and compare different methods of measuring mucociliary clearance. Methods: Twenty-nine patients with chronic rhinosinusitis were randomized in 2 operative groups (uncinectomy or balloon sinuplasty). Before and 6 months after the treatment, patients filled out a quality of life questionnaire (Sino Nasal Outcome Test-22 [SNOT-22]), and mucociliary clearance was measured with endoscope and gamma camera after 0.03 ml of saccharine, methylene-blue dye, and human album...περισσότερα »
Long-term Follow-up Results of Regeneration Process of Fungiform Taste Buds After Severing the Chorda Tympani Nerve During Middle Ear Surgery
Objective: To elucidate the regeneration process of fungiform taste buds after severing the chorda tympani nerve (CTN) by confocal laser scanning microscopy in vivo. Methods: In 7 consecutive patients whose CTN was severed during tympanoplasty, an average of 10 fungiform papillae in the midlateral region of the tongue were periodically observed, and the number of taste buds was counted until 12 to 24 months after surgery. Gustatory function was assessed by EGM. Results: EGM thresholds showed no response within 1 month after surgery in any patient. All taste buds had disappeare...περισσότερα »
External Branch of the Superior Laryngeal Nerve Mediated Glottic Closing Force in the Porcine Model
Objectives: Based on our laboratory's newly confirmed motor pathway for glottic closure, we measured the glottic closing force (GCF) during isolated stimulation of the external branch of the superior laryngeal nerve (eSLN) in the porcine model. Glottic closure is 1 of the primary mechanisms for prevention of aspiration during deglutition. Methods: The recurrent laryngeal nerve (RLN) and eSLN were identified bilaterally in 4 porcine necks. Subsequently, GCF was measured with a pressure transducer as the distal ends of individual nerves were stimulated in 4 animals. The RLN media... περισσότερα »
Childhood hydrocephalus secondary to posterior fossa tumor
is both an intra- and extraaxial process: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE Ventricular dilation secondary to tumor obstruction of the posterior fossa CSF outflow in childhood is an intraaxial process. However, third ventriculostomy or complete tumor removal often fails to reduce the pressure in some children, and in others there is a delayed reduction in intracranial pressure; this is termed the adaptation period. The cause of this adaptation period has not been studied. Venous sinus compression is highly correlated with other forms of childhood hydro... περισσότερα »
Age-related carbon dioxide reactivity in children after moderate and severe traumatic brain injury
Age-related carbon dioxide reactivity in children after moderate and severe traumatic brain injury: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The objective of this study is to assess carbon dioxide reactivity (CO2R) in children following traumatic brain injury (TBI). METHODS This prospective observational study enrolled children younger than 18 years old following moderate and severe TBI. Thirty-eight mechanically ventilated children had daily CO2R testing performed by measuring changes in their bilateral middle cerebral artery flow velocities using transcrani... περισσότερα »
Sporadic, neurofibromatosis Type 1–associated, and radiation-associated malignant peripheral nerve sheath tumors
Patterns of recurrence and survival in Journal of Neurosurgery, Ahead of Print. OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive group of soft tissue sarcomas that can arise sporadically, in the context of neurofibromatosis Type 1 (NF1) or at a site of prior irradiation. Large series profiling the features and outcomes of sporadic, NF1-associated, and radiation-associated MPNSTs are limited. The goal of this study was to elucidate differences between MPNST etiologies in a large single-institution retrospective study. METHODS Patients (n = 317) were id... περισσότερα »
Endoscopic transsphenoidal anterior petrosal approach for locally aggressive tumors involving the internal auditory canal, jugular fossa, and cavernous sinus
Endoscopic transsphenoidal anterior petrosal approach for locally aggressive tumors involving the internal auditory canal, jugular fossa, and cavernous sinus: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Reports about endoscopic endonasal surgery for skull base tumors involving the lateral part of petrous apex remain scarce. The authors present their experience with the endoscopic transsphenoidal anterior petrosal (ETAP) approach through the retrocarotid space for tumors involving the internal auditory canal, jugular fossa, and cavernous sinus. METHODS The authors performed t... περισσότερα »
Microsurgical resection or stereotactic radiosurgery for patients with small- and medium-sized vestibular schwannomas
A matched cohort comparison of clinical outcomes following : Journal of Neurosurgery, Ahead of Print. OBJECTIVE A randomized trial that compares clinical outcomes following microsurgery (MS) or stereotactic radiosurgery (SRS) for patients with small- and medium-sized vestibular schwannomas (VSs) is impractical, but would have important implications for clinical decision making. A matched cohort analysis was conducted to evaluate clinical outcomes in patients treated with MS or SRS. METHODS The records of 399 VS patients who were cared for by 2 neurosurgeons and 1 neurotologist betw...περισσότερα »
Severe traumatic brain injury: Impact of Glasgow Coma Scale score and pupil parameters
on mortality rate and outcome in pediatric and adult severe traumatic brain injury: a retrospective, multicenter cohort study: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Prediction of death and functional outcome is essential for determining treatment strategies and allocation of resources for patients with severe traumatic brain injury (TBI). The aim of this study was to evaluate, by using pupillary status and Glasgow Coma Scale (GCS) score, if patients with severe TBI who are ≤ 15 years old have a lower mortality rate and better outcome than adults with severe TBI. METHO... περισσότερα »
Language function at risk in patients with brain tumors
Interhemispheric connectivity revealed by diffusion tensor imaging fiber tracking derived from navigated transcranial magnetic stimulation maps as a sign of language function at risk in patients with brain tumors: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Resection of brain tumors in language-eloquent areas entails the risk of postoperative aphasia. It has been demonstrated via navigated transcranial magnetic stimulation (nTMS) that language function can partially shift to the unaffected hemisphere due to tumor-induced plasticity. Therefore, this study was designed to eval... περισσότερα »
Arteriovenous malformations in the cerebellopontine angle cistern
Clinical characteristics of Journal of Neurosurgery, Ahead of Print. OBJECTIVE Arteriovenous malformations (AVMs) in the cerebellopontine angle cistern (CPAC) are specific lesions that can cause neurovascular compression syndromes as well as intracranial hemorrhage. Although case reports describing the CPAC AVMs, especially those presenting with trigeminal neuralgia (TN), have been accumulating by degrees, the pathophysiology of CPAC AVMs remains obscure. The authors' purpose in the present study was to evaluate the clinical and radiographic features of CPAC AVMs as well as the t...περισσότερα »
Masseteric–facial nerve neurorrhaphy
: results of a case series: Journal of Neurosurgery, Ahead of Print. OBJECTIVE Facial palsy is a well-known functional and esthetic problem that bothers most patients and affects their social relationships. When the time between the onset of paralysis and patient presentation is less than 18 months and the proximal stump of the injured facial nerve is not available, another nerve must be anastomosed to the facial nerve to reactivate its function. The masseteric nerve has recently gained popularity over the classic hypoglossus nerve as a new motor source because of its lower associa... περισσότερα »
Pediatric meningioma recurrence
Prediction of pediatric meningioma recurrence by preoperative MRI assessment via Latest Results for Neurosurgical Review AbstractPreoperative identification of high-recurrent pediatric meningiomas with MRI features would help clinicians to make optimal treatment strategies; however, the relationships between radiological features and recurrence of meningiomas in pediatric population have not been clearly demonstrated yet. The aim of this study is to identify preoperative MRI features which are significant risk factors for recurrence of pediatric meningiomas. From January 2005 to Decem... περισσότερα »
The use of spine stereotactic radiosurgery for oligometastatic disease
The use of spine stereotactic radiosurgery for oligometastatic disease: Journal of Neurosurgery: Spine, Ahead of Print. OBJECTIVE The authors investigated the outcomes following spine stereotactic radiosurgery (SSRS) for patients with oligometastatic disease of the spine. METHODS The study was a secondary analysis of 38 of 209 patients enrolled in 2 separate institutional Phase I/II prospective protocols and treated with SSRS between 2002 and 2011. Of these 38 patients, 33 (87%) were treated for a solitary spine metastasis, with no other history of metastatic disease. SSRS was pres...περισσότερα »
Risk factors for surgical site infection in cranial neurosurgery
Implementation of a care bundle and evaluation of via Clinical Neurology and Neurosurgery [image: S03038467.gif] Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Benjamin M. Davies, Anna Jones, Hiren C. Patel ObjectivesSurgical site infection [SSI] increases mortality, morbidity and length of hospital stay. Peri-operative ‘care bundles’ have reduced SSI in some fields of surgery. The aim of this study was to determine the impact of bundle compliance on SSI in patients undergoing a craniotomy.Patients and methodCohort study of patients [N=... περισσότερα »
Microneurosurgery and subsequent gamma knife radiosurgery for functioning pituitary macroadenomas or giant adenomas
: one institution’s experience via Clinical Neurology and Neurosurgery Publication date: Available online 2 April 2016 *Source:*Clinical Neurology and Neurosurgery Author(s): Peng Fu, Yun-song He, Yong-cun Cen, Qin Huang, Ke-tai Guo, Hong-yang Zhao, Wei Xiang ObjectiveFunctioning pituitary macroadenoma and giant adenoma have large growth volumes and endocrinological abnormalities, requiring proper medical intervention. In this retrospective study, microneurosurgery and subsequent gamma knife radiosurgery (GKRS) is assessed for efficacy and safety for the treatment of functioning pitui...περισσότερα »
Foramen Magnum Meningioma
: the midline suboccipital subtonsillar approach via Clinical Neurology and Neurosurgery [image: S03038467.gif] Publication date: Available online 2 April 2016 *Source:*Clinical Neurology and Neurosurgery Author(s): S. Dobrowolski, F. Ebner, G. Lepski, M. Tatagiba ObjectivesForamen magnum meningiomas (FMMs) represent a technical challenge even for experienced neurosurgeons, because they grow in close contact with osteoarticular, nervous, and vascular structures that cannot be sacrificed or retracted during surgery. Our goal is to present our experience with 24 cases of surgically rese... περισσότερα »
Human papillomavirus vaccinations : Recurrent optic neuritis and neuromyelitis optica-IgG
following first and second human papillomavirus vaccinations via Clinical Neurology and Neurosurgery Publication date: May 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 144 Author(s): Hyeyeon Chang, Hye Lim Lee, Minju Yeo, Ji Seon Kim, Dong-Ick Shin, Sang-Soo Lee, Sung-Hyun Lee Human papillomavirus (HPV) vaccine is widely used to prevent cervical cancer caused by certain types of HPV in girls and young women. Demyelinating disorders within months following HPV innoculation have been reported, but the causal link between HPV vaccination and the onset of demyelinating disor...περισσότερα »
Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery
Combined 2D and 3D tracking of surgical instruments for minimally invasive and robotic-assisted surgery: Abstract PurposeComputer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of the surgical instruments. Instrument tracking is a challenging problem in both conventional and robotic-assisted MIS, but vision-based approaches are a promising solution with minimal hardware integration requirements. However, vision-based methods suffer from drift, and in the case of occlusions, shadows and fast motion, they can be subject to complete tracking fai...περισσότερα »
Robotic surgery training
: construct validity of Global Evaluative Assessment of Robotic Skills (GEARS): AbstractThe objective of this study is to determine the ability of the GEARS scale (Global Evaluative Assessment of Robotic Skills) to differentiate individuals with different levels of experience in robotic surgery, as a fundamental validation. This is a cross-sectional study that included three groups of individuals with different levels of experience in robotic surgery (expert, intermediate, novice) their performance were assessed by GEARS applied by two reviewers. The difference between groups was ... περισσότερα »
Transclival injury after routine transnasal rhinological surgery
Transclival injury after routine transnasal rhinological surgery via Clinical Neurology and Neurosurgery Publication date: June 2016 *Source:*Clinical Neurology and Neurosurgery, Volume 145 Author(s): Shadi Al-Afif, Makoto Nakamura, Thomas Lenarz, Joachim K. Krauss ObjectivesRoutine transnasal rhinological procedures are widely practiced and are considered as safe, in general. Skull base lesions occur in less than 1% of procedures and typically involve the anterior or middle cranial fossa, while clivus lesions have not been well documented. Here we present a series of three patients wi...περισσότερα »
A reinforcement of the sutured microvascular anastomosis with fibrin glue application
: A retrospective comparative study with the standard conventional technique: Purpose Although a reasonable number of studies report satisfactory results with fibrin glue application in microvascular anastomosis since 1977, its utilization in the clinical setting has being scant in the literature. The aim of this study was to report the cumulated experience with the fibrin glue in free flaps over a period of 10 years, comparing the survival rate with the standard sutured anastomosis. Patients and methods From August 2001 through November 2014, 83 consecutive free flaps were perform... περισσότερα »
False-positive uptake of 18F-FDG in hypoglossal nerve palsy following chemoradiotherapy for tongue base cancer
False-positive uptake of 18F-FDG in hypoglossal nerve palsy following chemoradiotherapy for tongue base cancer:
The manic phase of Bipolar disorder significantly impairs theory of mind decoding.
*The manic phase of Bipolar disorder significantly impairs theory of mind decoding.* Psychiatry Res. 2016 Mar 29;239:275-280 Authors: Hawken ER, Harkness KL, Lazowski LK, Summers D, Khoja N, Gregory JG, Milev R Abstract Bipolar disorder is associated with significant deficits in the decoding of others' mental states in comparison to healthy participants. However, differences in theory of mind decoding ability among patients in manic, depressed, and euthymic phases of bipolar disorder is currently unknown. Fifty-nine patients with bipolar I or II disorder (13 manic, 25 depressed, ... περισσότερα »
Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States.
*Associations of acoustically measured tongue/jaw movements and portion of time speaking with negative symptom severity in patients with schizophrenia in Italy and the United States.* Psychiatry Res. 2016 Mar 25;239:253-258 Authors: Bernardini F, Lunden A, Covington M, Broussard B, Halpern B, Alolayan Y, Crisafio A, Pauselli L, Balducci PM, Capulong L, Attademo L, Lucarini E, Salierno G, Natalicchi L, Quartesan R, Compton MT Abstract This is the first cross-language study of the effect of schizophrenia on speech as measured by analyzing phonetic parameters with sound spectrograph... περισσότερα »
Erratum to: Piloting a new approach in primary care to identify, assess and support carers of people with terminal illnesses: a feasibility study.
*Erratum to: Piloting a new approach in primary care to identify, assess and support carers of people with terminal illnesses: a feasibility study.* BMC Fam Pract. 2016;17(1):39 Authors: Carduff E, Jarvis A, Highet G, Lloyd A, Finucane A, Kendall M, Harrison N, Greenacre J, Murray SA PMID: 27039385 [PubMed - as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/1RTZCO3 via IFTTT
Preferential processing of emotionally and self-relevant stimuli persists in unconscious N2 sleep.
*Preferential processing of emotionally and self-relevant stimuli persists in unconscious N2 sleep.* Brain Lang. 2016 Mar 30; Authors: Blume C, Del Giudice R, Lechinger J, Wislowska M, Heib DP, Hoedlmoser K, Schabus M Abstract Information processing has been suggested to depend on the current state of the brain as well as stimulus characteristics (e.g. salience). We compared processing of salient stimuli (subject's own names [SONs] and angry voice [AV] stimuli) to processing of unfamiliar names (UNs) and neutral voice (NV) stimuli across different vigilance stages (i.e. wakefulne...περισσότερα »
The influence of the elements of procedural justice and speed camera enforcement on young novice driver self-reported speeding.
*The influence of the elements of procedural justice and speed camera enforcement on young novice driver self-reported speeding.* Accid Anal Prev. 2016 Mar 31;92:34-42 Authors: Bates L, Allen S, Watson B Abstract Road policing is an important tool used to modify road user behaviour. While other theories, such as deterrence theory, are significant in road policing, there may be a role for using procedural justice as a framework to improve outcomes in common police citizen interactions such as traffic law enforcement. This study, using a sample of 237 young novice drivers, consider...περισσότερα »
Structure-Activity Relationship of Lipid Core Peptide-based Group A Streptococcus Vaccine Candidates
Publication date: Available online 2 April 2016 *Source:*Bioorganic & Medicinal Chemistry Author(s): Amy Chan, Waleed M. Hussein, Khairunnisa Abdul Ghaffar, Nirmal Marasini, Ahmed Mostafa, Sharareh Eskandari, Michael R. Batzloff, Michael F. Good, Mariusz Skwarczynski, Istvan Toth Infection with Group A Streptococcus (GAS) can result in a range of different illnesses, some of which are fatal. Currently, our efforts to develop a vaccine against GAS focuses on the lipid core peptide (LCP) system, a subunit vaccine containing a lipoamino acid (LAA) moiety which allows the stimulation of...περισσότερα »
Sensors, Vol. 16, Pages 476: Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications
THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 °C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission... περισσότερα »
Societies, Vol. 6, Pages 10: Bodies Folded in Migrant Crypts: Dis/Ability and the Material Culture of Border-Crossing
This article considers media narratives that suggest that hiding in trucks, buses, and other vehicles to cross borders has, in fact, been a common practice in the context of migration to, and within, Europe. We aim to problematize how the tension between the materiality of bordering practices and human migrants generates a dis/abled subject. In this context, dis/ability may be a cause or consequence of migration, both in physical/material (the folding of bodies in the crypt) and cultural/semiotic terms, and may become a barrier to accessing protection, to entering and/or crossing ... περισσότερα »
Molecules, Vol. 21, Pages 448: Synthesis of Dense and Chiral Dendritic Polyols Using Glyconanosynthon Scaffolds
Most classical dendrimers are frequently built-up from identical repeating units of low valency (usually AB2 monomers). This strategy necessitates several generations to achieve a large number of surface functionalities. In addition, these typical monomers are achiral. We propose herein the use of sugar derivatives consisting of several and varied functionalities with their own individual intrinsic chirality as both scaffolds/core as well as repeating units. This approach allows the construction of chiral, dense dendrimers with a large number of surface groups at low dendrimer gen... περισσότερα »
Molecules, Vol. 21, Pages 448: Synthesis of Dense and Chiral Dendritic Polyols Using Glyconanosynthon Scaffolds
Most classical dendrimers are frequently built-up from identical repeating units of low valency (usually AB2 monomers). This strategy necessitates several generations to achieve a large number of surface functionalities. In addition, these typical monomers are achiral. We propose herein the use of sugar derivatives consisting of several and varied functionalities with their own individual intrinsic chirality as both scaffolds/core as well as repeating units. This approach allows the construction of chiral, dense dendrimers with a large number of surface groups at low dendrimer gen... περισσότερα »
Zooming in on the genesis of atherosclerotic plaque microcalcifications
Abstract Epidemiological evidence conclusively demonstrates that calcium burden is a significant predictor of cardiovascular morbidity and mortality; however, the underlying mechanisms remain largely unknown. These observations have challenged the previously held notion that calcification serves to stabilize the atherosclerotic plaque. Recent studies have shown that microcalcifications that form within the fibrous cap of the plaques lead to the accrual of plaque-destabilizing mechanical stress. Given the association between calcification morphology and cardiovascular outcomes, it... περισσότερα »
It’s Square Root Day! Prepare to be Somewhat Underwhelmed…
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
It’s kind of like Pi Day, but way, way less fun
IgE Reactivity of Recombinant Pac c 3 from the Asian Needle Ant (Pachycondyla chinensis)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Background: Stings from the Asian needle ant are an important cause of anaphylaxis in East Asia. A 23-kDa protein homologous to antigen 5 is the major allergen produced by these ants. In this study, we aimed to produce a recombinant antigen 5 allergen, Pac c 3. Methods: Recombinant Pac c 3 allergen from the Asian […]
Clinical Relevance of IgE to Profilin and/or Polcalcin in Pollen-Sensitized Patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Background: Component-resolved diagnostics is gaining importance in allergy diagnostics. Allergen extracts contain components with different rates of prevalence and clinical relevance, which can be subdivided at molecular level into major and minor allergens. Clinical complaints are usually triggered by major allergens, while the role of sensitization to the panallergens profilin and polcalcin still remains unclear. […]
Development of a Prediction Model Based on RBF Neural Network for Sheet Metal Fixture Locating Layout Design and Optimization
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Fixture plays an important part in constraining excessive sheet metal part deformation at machining, assembly, and measuring stages during the whole manufacturing process. However, it is still a difficult and nontrivial task to design and optimize sheet metal fixture locating layout at present because there is always no direct and explicit expression describing sheet metal […]
Channel Coordination in Logistics Service Supply Chain considering Fairness
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Logistics service supply chain (LSSC) is a new type of service supply chain. This paper investigates the channel coordination issue in a two-echelon LSSC composed of one logistics service integrator (LSI) and one functional logistics service provider (FLSP) under fairness concerns. The models for a reservation price-only contract under disadvantageous inequality and advantageous inequality are […]
Japanese Study Deals Another Blow to Deep-Roots Theory of War
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
An analysis of skeletons reveals that violence was rare among hunter-gatherers in prehistoric Japan.
CHMP issues a positive opinion on single-agent daratumumab for treatment of multiple myeloma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has issued a Positive Opinion recommending a conditional marketing authorisation for first-in-class CD38 immunotherapy daratumuma (Darzalex) in the European… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RX2VXS via IFTTT
Discovery of cellular counting mechanism used for size control in algae with links to cancer genetics
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
James Umen, Ph.D., associate member at Donald Danforth Plant Science Center, and colleagues have discovered a protein that enables the single-celled green alga Chlamydomonas to count cell divisions, a process that is critically important for its cells to… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RIgyFd via IFTTT
BPA changes foetal development of the mammary gland and can raise breast cancer risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
A new culture system that tests the role of chemical exposure on the developing mammary gland has found that bisphenol A (BPA) directly affects the mammary gland of mouse embryos. The study results, presented at the Endocrine Society’s 98th annual… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RX2Vr6 via IFTTT
More Latinas screened for breast cancer after ‘Promotora’ visits
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Latina women were nearly twice as likely to be screened for breast cancer after they were visited in their homes by trained community health workers, known as Promotoras, according to a study published in Cancer Epidemiology, Biomarkers and… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RIgyoA via IFTTT
Severe or life-threatening asthma exacerbation: patient heterogeneity identified by cluster analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Abstract Background Severe or life-threatening asthma exacerbation is one of the worst outcomes of asthma because of the risk of death. To date, few studies have explored the potential heterogeneity of this condition. Objectives To examine the clinical characteristics and heterogeneity of patients with severe or life-threatening asthma exacerbation. Methods This was a multicenter, prospective […]
IgE Reactivity of Recombinant Pac c 3 from the Asian Needle Ant (Pachycondyla chinensis)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Background: Stings from the Asian needle ant are an important cause of anaphylaxis in East Asia. A 23-kDa protein homologous to antigen 5 is the major allergen produced by these ants. In this study, we aimed to produce a recombinant antigen 5 allergen, Pac c 3. Methods: Recombinant Pac c 3 allergen from the Asian […]
Clinical Relevance of IgE to Profilin and/or Polcalcin in Pollen-Sensitized Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Background: Component-resolved diagnostics is gaining importance in allergy diagnostics. Allergen extracts contain components with different rates of prevalence and clinical relevance, which can be subdivided at molecular level into major and minor allergens. Clinical complaints are usually triggered by major allergens, while the role of sensitization to the panallergens profilin and polcalcin still remains unclear. […]
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Publication date: July 2016 Source:Neurobiology of Disease, Volume 91 Author(s): Feifei Ma, Pablo Martínez-San Segundo, Verónica Barceló, Anna Morancho, Marina Gabriel-Salazar, Dolors Giralt, Joan Montaner, Anna Rosell New neuroreparative and neuroprotective therapies are being sought to treat stroke patients. One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular […]
ADSA Member News …
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/225gUuj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Journal of Dairy Science® 2015 Editorial Report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): Matthew Lucy from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1W50SRC via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Letter to the Editor: Comments on Journal of Dairy Science statistical unit policy as it relates to pen-based animal studies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): Peter H. Robinson from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/225gVyk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Letter to the Editor: A Response to Robinson (2016)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): W.R. Lamberson from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1W50SRv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Teeth Close Up- Leetha O!
The post Teeth Close Up- Leetha O! appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/225lRTT via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Experimental polyethylene–hydroxyapatite carrier-based endodontic system: an in vitro study on dynamic thermomechanical properties, sealing ability, and measurements of micro-computed tomography voids
The dynamic thermomechanical properties, sealing ability, and voids formation of an experimental obturation hydroxyapatite-reinforced polyethylene (HA/PE) composite/carrier system were investigated and compared with those of a commercial system [GuttaCore (GC)]. The HA/PE system was specifically designed using a melt-extrusion process. The viscoelastic properties of HA/PE were determined using a dynamic thermomechanical analyser. Human single-rooted teeth were endodontically instrumented and obturated using HA/PE or GC systems, and then sealing ability was assessed using a fluid ... περισσότερα »
Negative maple-leaf like areas for basal cell carcinoma margin recognition
Negative maple-leaf like areas: a new clue for basal cell carcinoma margin recognition: Abstract Dermoscopy and reflectance confocal microscopy (RCM) improved accuracy in the diagnosis of both pigmented and non-pigmented basal cell carcinoma (BCC) in the early stages 1-4. The classical dermoscopy algorithm includes lack of pigment network and the presence of at least one of the following criteria: ulceration, maple-leaf like areas, blue-gray globules, blue ovoid nests, arborizing vessels and spoke-wheel structures 5. Our goal is to describe a new dermoscopic finding, negative maple-...περισσότερα »
Vitiligo of DRESS syndrome
Vitiligo: A potential autoimmune sequela of DRESS syndrome: Abstract Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) is a systemic drug hypersensitivity reaction characterized by rash and multiorgan involvement. DRESS syndrome is associated with the development of multiple autoimmune conditions. Here we present a case of DRESS syndrome followed by vitiligo. A 45-year-old woman with a history of type 2 diabetes mellitus, hypertension, and breast cancer presented with fever and a diffuse rash nine days after starting amoxicillin/clavulanic acid for acute sinusitis. This arti... περισσότερα »
Nodules behind the ears
IgG4-related skin disease: Summary A 53-year-old healthy factory worker consulted our hospital complaining of small nodules of similar size, shape and location on both ears. The nodules revealed focal and massive infiltration of lymphocytes, plasma cells and eosinophils with fibrosis that had no specific structure on pathological staining with hematoxylin and eosin. Immunostaining for immunoglobulin (Ig) G4 revealed that a large majority of the IgG+ cells were positive for IgG4. The ratio of IgG4+ to IgG+ plasma cells was approximately 40%. IgG4+ plasma cells were present at approx... περισσότερα »
Patient-performed mobile teledermoscopy for the early detection of melanoma
Consumer acceptance of Abstract Background Mobile teledermoscopy allows consumers to send images of skin lesions to a teledermatologist for remote diagnosis. Currently, technology acceptance of mobile teledermoscopy by people at high risk of melanoma is unknown. Objectives We aimed to determine acceptance of mobile teledermoscopy by consumers based on: perceived usefulness; ease of use; compatibility; attitude, intention; subjective norms; facilitators, and trust before use. Satisfaction was explored after use. Methods Consumers 50-64 years at high risk of melanoma (fair skin, or pre...περισσότερα »
Primary cutaneous anaplastic large cell lymphoma
KIR3DL2 (CD158k) is a potential therapeutic target in primary cutaneous anaplastic large cell lymphoma: Abstract Background KIR3DL2, an inhibitory receptor expressed by NK-cells and a subset of normal CD8+ T cells, is aberrantly expressed in neoplastic cells in transformed mycosis fungoides and Sézary Syndrome. Anti-KIR3DL2 targeted antibody therapy has shown potent activity in preclinical models for these diseases. Objectives To examine the expression of KIR3DL2 and its potential use as therapeutic target in patients with primary cutaneous anaplastic large cell lymphomas (pcALCL),... περισσότερα »
PD-1 blockade for treatment of metastatic Merkel cell carcinoma
PD-1 blockade — a therapeutic option for treatment of metastatic Merkel cell carcinoma: Abstract Background The immune system is extremely important in the development and progression of Merkel cell carcinoma (MCC). Immune checkpoint blockade has recently been shown to enable efficacious treatment of a variety of tumours. We report use of an anti-PD-1 antibody for treatment of a patient with metastatic MCC. Case Report An 80-year-old patient with metastatic MCC received off-label treatment with the anti-PD-1 antibody pembrolizumab after the disease had progressed during therapy wit...περισσότερα »
The reliability of Mohs slides diagnosis on basal cell carcinoma (BCC)
Reliability of Mohs slides diagnosis: interpersonal and intrapersonal agreement on basal cell carcinoma presence and histological subtype: Abstract Background Success of Mohs micrographic surgery (MMS) partly depends on correct diagnosis of slides. Objective To determine reliability of Mohs slides diagnosis. Methods Prospective study evaluating the reliability of Mohs slides diagnosis on basal cell carcinoma (BCC) presence, BCC location on the slide and BCC subtype among six raters who independently assessed 50 Mohs slides twice with two months interval. Slides were randomly selected... περισσότερα »
Delayed pressure urticaria
treated with the selective serotonin reuptake inhibitor escitalopram: Summary There is increasing evidence of platelet activation and systemic inflammation in chronic spontaneous urticaria and delayed pressure urticaria (DPU). Inflammation may be central to understanding the high comorbidity of depression and anxiety in patients with chronic urticaria (CU). We report a case of DPU and depression in a patient, which responded favourably to treatment with the selective serotonin reuptake inhibitor (SSRI) escitalopram. Sustained administration of SSRIs is associated with downregulati... περισσότερα »
Perioperative complications in open versus percutaneous treatment of spinal fractures in patients with an ankylosed spine.
*Perioperative complications in open versus percutaneous treatment of spinal fractures in patients with an ankylosed spine.* J Clin Neurosci. 2016 Mar 30; Authors: Moussallem CD, McCutcheon BA, Clarke MJ, Cui Q, Currier BL, Yaszemski MJ, Huddleston PM, Rose PS, Freedman B, Dekutoski MB, Bydon M, Nassr A Abstract We compared open stabilization of vertebral fractures to percutaneous spinal fixation techniques in patients with a diagnosis of either ankylosing spondylitis (AS) or diffuse idiopathic skeletal hyperostosis (DISH). A retrospective review of patients known to have AS or D...περισσότερα »
Hyperthyroidism.
*Hyperthyroidism.* Lancet. 2016 Mar 30; Authors: De Leo S, Lee SY, Braverman LE Abstract Hyperthyroidism is characterised by increased thyroid hormone synthesis and secretion from the thyroid gland, whereas thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. The most common cause of hyperthyroidism is Graves' disease, followed by toxic nodular goitre. Other important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingestion of excess thyroid hormones. T...περισσότερα »
Tremor in progressive supranuclear palsy.
*Tremor in progressive supranuclear palsy.* Parkinsonism Relat Disord. 2016 Mar 22; Authors: Fujioka S, Algom AA, Murray ME, Sanchez-Contreras MY, Tacik P, Tsuboi Y, Van Gerpen JA, Uitti RJ, Rademakers R, Ross OA, Wszolek ZK, Dickson DW Abstract INTRODUCTION: Tremor is thought to be a rare feature of progressive supranuclear palsy (PSP). METHODS: We retrospectively reviewed the database of the CurePSP brain bank at Mayo Clinic Florida to retrieve all available clinical information for PSP patients. All patients underwent a standard neuropathological assessment and an immunohistoc... περισσότερα »
Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype.
*Baicalin ameliorates experimental inflammatory bowel disease through polarization of macrophages to an M2 phenotype.* Int Immunopharmacol. 2016 Mar 31;35:119-126 Authors: Zhu W, Jin Z, Yu J, Liang J, Yang Q, Li F, Shi X, Zhu X, Zhang X Abstract Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract. Baicalin, originally isolated from the root of the Chinese herb Huangqin (Scutellaria baicalensis Georgi) and its main active ingredient, has a protective effect against inflammatory responses in several diseases. The present study investigated t... περισσότερα »
Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes.
*Sulforaphane regulates phenotypic and functional switching of both induced and spontaneously differentiating human monocytes.* Int Immunopharmacol. 2016 Mar 31;35:85-98 Authors: Pal S, Konkimalla VB Abstract At the site of inflammation, switching default on polarization of monocyte differentiation into classically activated macrophages (M1 type) is one of the pathogenic outcomes in several inflammatory autoimmune diseases, such as rheumatoid arthritis and osteoarthritis. In rheumatoid and osteoarthritis, a soluble collagen known as self-antigen is considered as a biomarker and a... περισσότερα »
High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.
*High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.* Eur J Cancer. 2016 Mar 31;59:152-159 Authors: Finkelmeier F, Canli Ö, Tal A, Pleli T, Trojan J, Schmidt M, Kronenberger B, Zeuzem S, Piiper A, Greten FR, Waidmann O Abstract AIM: Immunotherapy in cancer is a recent and very promising approach, namely the inhibition of the PD/programmed death-ligand 1 (PD-L1) axis. Here we aimed to investigate the prognostic value of a soluble form of PD-L1 in hepatocellular carcinoma (HCC) patients. METHODS: HCC patients ...περισσότερα »
Tissue reaction to urogynecologic meshes: effect of steroid soaking in two different mesh models.
*Tissue reaction to urogynecologic meshes: effect of steroid soaking in two different mesh models.* Int Urogynecol J. 2016 Apr 2; Authors: Karabulut A, Simavlı SA, Abban GM, Akyer ŞP, Keskin N, Tan S, Şahin B Abstract INTRODUCTION AND HYPOTHESIS: Steroid soaking may decrease mesh-triggered inflammatory reaction in tissue. We aimed to investigate the tissue reaction to a steroid-soaked mesh material and an unsoaked mesh material in the rat model. METHODS: Neutral and steroid-soaked type I macroporous polypropylene (PP) monofilament and polyvinylidene fluoride (PVF) mesh materials ...περισσότερα »
Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles.
*Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles.* Colloids Surf B Biointerfaces. 2016 Mar 22;143:511-517 Authors: Lee GH, Lee SJ, Jeong SW, Kim HC, Park GY, Lee SG, Choi JH Abstract Utilizing the biological activities of compounds by encapsulating natural components in stable nanoparticles is an important strategy for a variety of biomedical and healthcare applications. In this study, quercetin-loaded silica nanoparticles were synthesized using an oil-in-water microemulsion method, which is a suitable system for producing functional nanopart... περισσότερα »
The role of regulator Eha in Edwardsiella tarda pathogenesis and virulence gene transcription.
*The role of regulator Eha in Edwardsiella tarda pathogenesis and virulence gene transcription.* Microb Pathog. 2016 Mar 30; Authors: Gao D, Li Y, Xu Z, Sheng A, Zheng E, Shao Z, Liu N, Chengping L Abstract Edwardsiella tarda is a pathogen with a broad host range that infects both animals and humans. Eha is a new transcriptional regulator identified in ET13, which is involved in the bacterial hemolytic activity. This study explored the effect of the Eha in the pathogenesis of E. tarda and the transcriptional regulation of the bacterial virulence genes (eseC, fliC, pagC and fimA).... περισσότερα »
Stevens–Johnson syndrome and toxic epidermal necrolysis
Variable levels of apoptotic signal-associated cytokines in the disease course of patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: Abstract Background/Objectives Keratinocyte death is a hallmark of Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). Apoptotic signal-associated cytokines, such as TNF-α, sFasL, granulysin, sTRAIL and IFN-γ have been reported to participate in keratinocyte apoptosis. However, their levels are variable, which hampers the elucidation of the role of these cytokines. We sought to determine whether cytokine levels vary ...περισσότερα »
Cocoa pod extract as antiwrinkle gel on human skin surface
Efficacy of [image: cover.gif?v=1&s=19c2d79892e4760373b0a4ba] Summary Objective Cocoa pods are abundant waste materials of cocoa plantation, which are usually discarded onto plantation floors. However, due to poor plantation management, the discarded cocoa pods can create suitable breeding ground for *Phytophthora palmivora*, which is regarded as the causal agent of the black pod disease. On the other hand, cocoa pods potentially contain antioxidant compounds. Antioxidant compounds are related to the protection of skin from wrinkles and can be used as functional cosmetic ingredi... περισσότερα »
Shin-Guard Dermatitis
Detection and Protection: Abstract With the popularity of soccer among American youth and the associated use of protective shin guards, dermatitis from the guard components has emerged. Awareness and protective measures may help prevent irritation and the development of contact sensitization from the guards.
Effectiveness and safety profile of 40% trichloroacetic acid and cryotherapy
for plantar warts: Abstract Plantar warts are one of the most common infectious skin disease caused by the human papillomavirus. In this study, cryotherapy with liquid nitrogen delivered by the physician, up to four treatments 2 weeks apart. Forty percent trichloroacetic acid (TCA) was applied to warts weekly up to four treatments. At the end of 4 weeks, the clinical improvement of the TCA group (*n* = 30) was six patients (20%) with no change, one patient (3.3%) with a mild response, 13 patients (43.3%) with a moderate response and 10 patients (33.3%) with a good response. In the...περισσότερα »
2.5% Lidocaine/Prilocaine Hydrogel in Children
Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum: Abstract The tolerability of a 2.5% lidocaine/prilocaine hydrogel (Nanorap, Biolab Indústria Farmacêutica Ltd., Sao Paulo, Brazil) was evaluated in 20 children ages 2 to 11 years undergoing cryotherapy for molluscum contagiosum (MC). The product was well tolerated, with only two children presenting with eczema at the application site. These adverse reactions were considered unlikely to be related to the test product, because a patch test was negative in one of the indivi... περισσότερα »
Fetal Alcohol Exposure and PHACE Syndrome
: A Case and Autopsy Report: Abstract This report describes the clinical, radiologic, and autopsy findings of a newborn with PHACE syndrome (posterior fossa malformations, hemangioma, arterial anomalies, cardiac defects, and eye anomalies) and fetal alcohol spectrum disorder. To our knowledge, the concurrence of these conditions has not been reported in the literature.
Marijuana use starting in youth implicated in financial woes
Long-term, heavy pot smoking linked to financial troubles by age 38. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/25G9geq via IFTTT
Childhood Cutaneous Langerhans Cell Histiocytosis
Topical Imiquimod for the Treatment Abstract Although topical steroids are considered first-line treatment for cutaneous Langerhans cell histiocytosis (LCH), the appropriate therapy for refractory cases remains controversial. We report a 16-month-old girl with isolated cutaneous LCH refractory to treatment with topical corticosteroids and topical tacrolimus. Treatment was initiated with 5% topical imiquimod cream and the rash completely resolved after 5 months of therapy. There was no disease recurrence after more than 2 years of follow-up. We present this case to highlight imiquimo... περισσότερα »
Hereditary cerebellar degenerations
Experimental neurotransplantation treatment for hereditary cerebellar ataxias: AbstractHereditary cerebellar degenerations are a heterogeneous group of diseases often having a detrimental impact on patients’ quality of life. Unfortunately, no sufficiently effective causal therapy is available for human patients at present. There are several therapies that have been shown to affect the pathogenetic process and thereby to delay the progress of the disease in mouse models of cerebellar ataxias. The second experimental therapeutic approach for hereditary cerebellar ataxias is neurotra... περισσότερα »
ADSA Member News …
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 from Pharmacology via ola Kala on Inoreader http://ift.tt/225gUuj via IFTTT
Journal of Dairy Science® 2015 Editorial Report
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): Matthew Lucy from Pharmacology via ola Kala on Inoreader http://ift.tt/1W50SRC via IFTTT
Letter to the Editor: Comments on Journal of Dairy Science statistical unit policy as it relates to pen-based animal studies
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): Peter H. Robinson from Pharmacology via ola Kala on Inoreader http://ift.tt/225gVyk via IFTTT
Paediatric nasopharyngeal cytology
a new diagnostic opportunity?: AbstractThe purpose of this investigation was to describe the first application of nasopharyngeal cytology (NPC), a new cytological technique to collect cellular material from the nasopharyngeal surface non-invasively in children with chronic adenoiditis associated with recurrent acute otitis media and/or otitis media with effusion. Cellular material was collected transorally using an extra-thin flexible wire nasopharyngeal swab and then examined under a light microscope. The diagnostic accuracy of NPC in detecting the presence of allergy and pathogen...περισσότερα »
CNS invasion by H5N1 virus via the olfactory nerve
Vaccination is more effective than prophylactic oseltamivir in preventing CNS invasion by H5N1 virus via the olfactory nerve: *Background.* Influenza A viruses can replicate in the olfactory mucosa and subsequently use the olfactory nerve to enter the central nervous system (CNS). It is currently unknown whether intervention strategies are able to reduce or prevent influenza virus replication within the olfactory mucosa and subsequent spread to the CNS. Therefore, we tested the efficacy of homologous vaccination and prophylactic oseltamivir to prevent H5N1 virus CNS invasion via th... περισσότερα »
Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization
Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization: Abstract The study aimed to detect the variants of human papillomavirus (HPV) type 16 E6 and E7 in patients with cervical high - grade squamous intraepithelial lesion (HSIL), and to determine the existence and recurrence of persistent infection after treatment with loop electrosurgical excision procedure (LEEP). Preoperatively collected cervical exfoliated cells from one hundred HPV 16 positi... περισσότερα »
Invasive candidiasis (IC) including candidemia and deep-seated candidiasis
Impact of New Diagnostic Approaches for Invasive Candidiasis on Antifungal Stewardship: Abstract BackgroundInvasive candidiasis (IC) including candidemia and deep-seated candidiasis is associated with up to 50 % overall mortality and up to $80,000 in attributable cost (2015 US$). Rapid diagnostic tests (RDTs) for *Candida* have been developed. However, whether RDTs along with real-time decision support translate to better attainment of stewardship goals—improve clinical outcomes, minimize unintended consequences of antifungal use, and reduce healthcare costs—is unknown. The purpos...περισσότερα »
68Ga-NOTA-UBI-29-41 as a PET Tracer for Detection of Bacterial Infection
68Ga-NOTA-UBI-29-41 as a PET Tracer for Detection of Bacterial Infection: The cationic peptide 68Ga-NOTA-UBI-29-41 was synthesized and characterized. Biodistribution and PET/CT examinations were performed for evaluation of its biologic behavior. Differentiation of infection from sterile inflammation was investigated using microbiology methods at the sites of bacterial infections. *Methods:* Labeling of UBI-29-41 conjugated with NOTA with 68Ga was optimized at 20°C–100°C and pH 3.5–5.5. Radiochemical purity, stability up to 260 min, and binding to serum proteins were determined. In ...περισσότερα »
A stratified myeloid system, the challenge of understanding macrophage diversity.
*A stratified myeloid system, the challenge of understanding macrophage diversity.* Semin Immunol. 2016 Mar 30; Authors: Geissmann F, Mass E Abstract The present issue of 'Seminars in Immunology' addresses the topic of macrophage biology, 100 years after the death of Elie Metchnikoff (May 1845-July 1916). As foreseen by Metchnikoff, the roles of macrophages in the maintenance of homeostasis and immunity against pathogens have become a broad and active area of investigation. We now start to realize that the myeloid system includes a multiplicity of cell types with diverse develop... περισσότερα »
Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages.
*Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages.* Bioorg Med Chem Lett. 2016 Mar 25; Authors: Chen LQ, Shen XF, Hu BY, Lin Y, Igbe I, Zhang CG, Zhang GL, Yuan XH, Wang F Abstract Natural phenanthrene derivatives are considered to be important resource for the anti-inflammatory therapeutics, but their structure-activity relationship and mechanisms are still unknown. In this study we evaluated 20 synthesized phenanthrene analogs in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compounds 10, ... περισσότερα »
Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors.
*Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 29; Authors: Berge TI, Helland SB, Sælen A, Øren M, Johannessen AC, Skartveit L, Grung B Abstract OBJECTIVE: To describe and analyze recurrent pattern of KOTs according to time. STUDY DESIGN: This retrospective chart study evaluated histologically confirmed nonsyndromic keratocystic odontogenic tumors (KOT) treated at our institutions between 1975 and 2012. RESULTS: Mean age at time of diagnosis was 48 years, and male/female ratio was 1.8:1. The typical non...περισσότερα »
Assessment of furcal perforations in the vicinity of different root canal sealers using a cone beam computed tomography system with and without the application of artifact reduction mode: an ex vivo investigation on extracted human teeth.
*Assessment of furcal perforations in the vicinity of different root canal sealers using a cone beam computed tomography system with and without the application of artifact reduction mode: an ex vivo investigation on extracted human teeth.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 21; Authors: Kamburoğlu K, Yılmaz F, Yeta EN, Özen D Abstract OBJECTIVE: To investigate observer ability to diagnose ex vivo simulated endodontic furcal perforations in root-filled teeth from cone beam computed tomography (CBCT) images using different artifact reduction algorithms. STUDY DESI...περισσότερα »
Inherent physical characteristics and gene expression differences between alveolar and basal bones.
*Inherent physical characteristics and gene expression differences between alveolar and basal bones.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 21; Authors: Zakhary I, Alotibi F, Lewis J, ElSalanty M, Wenger K, Sharawy M, Messer RL Abstract OBJECTIVES: The objective of this study was to evaluate the baseline differences between alveolar and basal areas of the rat mandible. STUDY DESIGN: Rat mandibular alveolar and basal bones were evaluated using histology and micro-computed tomography to compare osteocyte number as well as bone density and architecture and polymerase c...περισσότερα »
Primary mucosal melanoma of the oral cavity: current therapy and future directions.
*Primary mucosal melanoma of the oral cavity: current therapy and future directions.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 14; Authors: Chatzistefanou I, Kolokythas A, Vahtsevanos K, Antoniades K Abstract BACKGROUND: Primary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas (OMMs) and provide a review of the literature with regard to treatment guidelines for and prognosis of this pathologic entity. STUDY DESIGN: We report three cases of OMMs treated...περισσότερα »
A Novel Brain PET/CT Scanner
National Electrical Manufacturers Association and Clinical Evaluation of a Novel Brain PET/CT Scanner: The aim of this study was to determine the performance of a novel mobile human brain/small-animal PET/CT system. The scanner has a 35.7-cm-diameter bore and a 22-cm axial extent. The detector ring has 7 modules each with 3 x 4 cerium-doped lutetium yttrium orthosilicate crystal blocks, each consisting of 22 x 22 outer-layer and 21 x 21 inner-layer crystals, each layer 1-cm thick. Light is collected by 12 x 12 silicon photomultipliers. The integrated CT can be used for attenuation ... περισσότερα »
Biallelic mutations with deafness is called Jervell and Lange–Nielsen syndrome (JLNS)
KCNQ1 mutations associated with Jervell and Lange–Nielsen syndrome and autosomal recessive Romano–Ward syndrome in India—expanding the spectrum of long QT syndrome type 1: Long QT syndrome type 1 (LQT1) is the most common type of all Long QT syndromes (LQTS) and occurs due to mutations in *KCNQ1*. Biallelic mutations with deafness is called Jervell and Lange–Nielsen syndrome (JLNS) and without deafness is autosomal recessive Romano–Ward syndrome (AR RWS). In this prospective study, we report biallelic mutations in *KCNQ1* in Indian patients with LQT1 syndrome. Forty patients with a... περισσότερα »
TENM1 mutations in Congenital General Anosmia
A role for by Anna Alkelai, Tsviya Olender, Rebecca Haffner-Krausz, Michael M. Tsoory, Valery Boyko, Pavlo Tatarskyy, Ruth Gross-Isseroff, Roni Milgrom, Sagit Shushan, Ilan Blau, Evyatar Cohn, Rachel Beeri, Levy-Lahad Ephrat, Elon Pras, Doron Lancet via Clinical Genetics Abstract Congenital general anosmia (CGA) is a neurological disorder entailing a complete innate inability to sense odors. While the mechanisms underlying vertebrate olfaction have been studied in detail, there are still gaps in our understanding of the molecular genetic basis of innate olfactory disorders. Applying... περισσότερα »
Hyperthyroidism.
*Hyperthyroidism.* Lancet. 2016 Mar 30; Authors: De Leo S, Lee SY, Braverman LE Abstract Hyperthyroidism is characterised by increased thyroid hormone synthesis and secretion from the thyroid gland, whereas thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. The most common cause of hyperthyroidism is Graves' disease, followed by toxic nodular goitre. Other important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingestion of excess thyroid hormones. T...περισσότερα »
THE BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY: A TWO YEAR INSTITUTIONAL AUDIT
2016-04-04T04-18-37Z *Source:* International Journal of Current Research and Review Salma Bhat, Nazia Bhat, Humaira Bashir, Summiya Farooq, Ruby Reshi, Mir Junaid Nazeir, Isma Niyaz. Fine needle aspiration cytology (FNAC) of thyroid plays a significant crucial role in cytopathology worldwide. Thyroid FNAC is extremely useful in identifying a substantial proportion of thyroid nodules as benign and reducing unnecessary surgery for patients with benign disease. The present study was done with the aim of stratifying thyroid cytology smears by The Bethesda System For Reporting Thyroid Cy...περισσότερα »
Racial differences in acute kidney injury of hospitalized adults with diabetes
Journal of Diabetes and its Complications from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPn0jM
The association between osteoporotic hip fractures and actinic lesions as a biomarker for cumulative sun exposure in older people—a retrospective case–control study in Argentina
Journal of Bone and Mineral Metabolism from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpEWz
Facilitators and barriers for effective academic-community collaboration for disaster preparedness and response
Journal of Public Health Management and Practice from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPn03l
Pharmacokinetics of cefoperazone/sulbactam in critically ill patients receiving continuous venovenous hemofiltration
European Journal of Clinical Pharmacology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpDlq
An Assessment of State Board of Pharmacy Legal Documents for Public Health Emergency Preparedness
American Journal of Pharmaceutical Education from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmZMV
Procalcitonin-guided therapy for the initiation of antibiotics in the emergency department: a systematic review
The American Journal of Emergency Medicine from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpD51
Acute pneumonia
Critical Care Nursing Quarterly from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmZwp
Urgent surgery after emergency presentation for colorectal cancer has no impact on overall and disease-free survival: a propensity score analysis
BMC Cancer from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpCOC
Mental health outcomes of burn: A longitudinal population-based study of adults hospitalized for burns
Burns from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmZwe
Neuropsychiatric predictors of post-injury headache after mild-moderate traumatic brain injury in veterans
Headache: The Journal of Head and Face Pain from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpCOu
Variation in ICU utilization and mortality after blunt splenic injury
Journal of Surgical Research from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmZfQ
A randomized trial of clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated wound infection
Clinical Infectious Diseases from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpAX1
The Effectiveness of Exercise on Recovery and Clinical Outcomes in Patients With Soft Tissue Injuries of the Hip, Thigh, or Knee: A Systematic Review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration
Journal of Manipulative and Physiological Therapeutics from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmXog
The incidence of deep venous thrombosis before arthroscopy among patients suffering from high-energy knee trauma
Knee Surgery, Sports Traumatology, Arthroscopy from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpApW
Injury Patterns After the Landslide Disaster in Oshima, Tokyo, Japan on October 16, 2013
Disaster Medicine and Public Health Preparedness from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmYZk
Single centre experience of combat-related vascular injury in victims of Syrian conflict: Retrospective evaluation of risk factors associated with amputation
Injury from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpBKw
Threat of secondary chemical contamination of emergency departments and personnel: an uncommon but recurrent problem
Disaster Medicine and Public Health Preparedness from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmX7M
The prevalence of crash risk factors in a population-based study of motorcycle riders
Injury from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpApM
Obturator nerve transfer to the branch of the tibial nerve innervating the gastrocnemius muscle for the treatment of sacral plexus nerve injury
Neurosurgery from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UPmX7D
Association of renal stress/damage and filtration biomarkers with subsequent AKI during hospitalization among patients presenting to the emergency department
Clinical Journal of the American Society of Nephrology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1pZpBu0
The Effect of a Full Bladder on Proportions of Diagnostic Ultrasound Studies in Children with Suspected Appendicitis
Research Articles Marshall Ross, Sasha Selby, Naveen Poonai, Helena Liu, Shabnam Minoosepehr, Graham Boag, Robin Eccles, Graham Thompson Canadian Journal of Emergency Medicine,FirstView Article(s), 6 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1RI6nAu
A stratified myeloid system, the challenge of understanding macrophage diversity.
*A stratified myeloid system, the challenge of understanding macrophage diversity.* Semin Immunol. 2016 Mar 30; Authors: Geissmann F, Mass E Abstract The present issue of 'Seminars in Immunology' addresses the topic of macrophage biology, 100 years after the death of Elie Metchnikoff (May 1845-July 1916). As foreseen by Metchnikoff, the roles of macrophages in the maintenance of homeostasis and immunity against pathogens have become a broad and active area of investigation. We now start to realize that the myeloid system includes a multiplicity of cell types with diverse develop... περισσότερα »
Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages.
*Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages.* Bioorg Med Chem Lett. 2016 Mar 25; Authors: Chen LQ, Shen XF, Hu BY, Lin Y, Igbe I, Zhang CG, Zhang GL, Yuan XH, Wang F Abstract Natural phenanthrene derivatives are considered to be important resource for the anti-inflammatory therapeutics, but their structure-activity relationship and mechanisms are still unknown. In this study we evaluated 20 synthesized phenanthrene analogs in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Compounds 10, ... περισσότερα »
Multiple-Metal (De-)Hydrogenation-Catalysed Processes
Abstract The use of different metals acting together in a synergistic way allows synthetic transformations that are not achievable by other means. Metal cooperation becomes important in catalytic processes for the synthesis of compounds with sophisticated structures or for difficult transformations. Rational design of multiple-metal-catalysed processes requires that the metal complexes and reaction conditions are compatible, which in general is not straightforward. A key feature for success found in all systems involving multimetallic processes is catalyst stability. The use of rob... περισσότερα »
Oxymetazoline Applied Topically to the Nasal Mucosa Decreases Trans-Mucosal Nitrous Oxide Exchange for the Middle Ear
Objective: Determine if the middle ear (ME) trans-mucosal nitrous oxide (N2O) gas exchange rate can be pharmacologically modulated by the nasal application of a vasoconstrictor. Methods: In a randomized, double-blind, crossover study, 20 adults received a nasal spray challenge containing either oxymetazoline or saline (placebo). At each session, subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes. Throughout, heart rate, blood pressure (BP), and blood O2 saturation were monitored, and b... περισσότερα »
Outcomes of Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis in Children: Associations With Age and Time Since Injury
Objective: Outcomes of laryngeal reinnervation with ansa-cervicalis for unilateral vocal fold paralysis (UVFP) may be influenced by age of the patient and time interval between laryngeal nerve injury and reinnervation, suggesting less favorable outcomes in older patients and greater than 2-year time interval after injury. This study examines these issues in the pediatric population. Method: Review of prospectively collected data set of 35 children and adolescents (1-21 years) that underwent ansa-recurrent laryngeal nerve (RLN) laryngeal reinnervation for UVFP. Results: The ti... περισσότερα »
Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment
Abstract Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop because of (1) failed induction of tolerance upon initial exposure to food antigen or (2) breakdown of established tolerance to food antigen. We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconventional IgE-mediated food allergy to mammalian meat known as alpha-gal food allergy. We highlight emerging data ... περισσότερα »
Autologous Fat Grafting in Onco-Plastic Breast Reconstruction; A Systematic Review on Oncological and Radiological safety, Complications, Volume Retention, and Patient/Surgeon Satisfaction
Publication date: Available online 29 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): J. Groen, V.L. Negenborn, D.J.W.R. Twisk, PhD. Rizopoulos, J.C.F. Ket, J.M. Smit, M.G. Mullender ObjectiveThis study aims to give an up-to-date overview of literature on autologous fat grafting (AFG) in onco-plastic breast reconstruction, with regard to complications, oncological and radiological safety, volume retention, and patient/surgeon satisfaction.BackgroundAlthough AFG is increasingly being applied in onco-plastic breast reconstruction, a comprehensive ... περισσότερα »
Five surgical maneuvers on nasal mucosa movement in cleft palate repair – a cadaver study
Publication date: Available online 29 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Dennis C. Nguyen, Kamlesh B. Patel, Rajiv P. Parikh, Gary B. Skolnick, Albert S. Woo IntroductionThis biomechanical study aims to characterize the nasal mucosa during palatoplasty, describing the soft tissue attachments at different zones and quantifying movement following their release.MethodsPalatal nasal mucosa was exposed and divided in the midline in 10 adult cadaver heads. Five consecutive maneuvers were performed: (1) elevation of nasal mucosal off the m... περισσότερα »
Microsurgical Reconstruction of Oncological Scalp Defects in the Elderly
Publication date: Available online 29 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Filip Simunovic, Steffen U. Eisenhardt, Vincenzo Penna, Jan R. Thiele, G. Björn Stark, Holger Bannasch The incidence of scalp tumors requiring radical excision increases with age. Free-flap surgery is the standard reconstructive option for large defects, however there is ongoing uncertainty about its safety in the elderly. We conducted a review of data and report on 19 cases older than 75 and 13 younger than 75 years. Data regarding patient demographics, types o...περισσότερα »
Need for Sun cream with your manicure? - Dangers of UV nail dryers
Publication date: Available online 28 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): J. Wilson, J. Maraka from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1RIfpgQ via IFTTT
Zooming in on the genesis of atherosclerotic plaque microcalcifications
Abstract Epidemiological evidence conclusively demonstrates that calcium burden is a significant predictor of cardiovascular morbidity and mortality; however, the underlying mechanisms remain largely unknown. These observations have challenged the previously held notion that calcification serves to stabilize the atherosclerotic plaque. Recent studies have shown that microcalcifications that form within the fibrous cap of the plaques lead to the accrual of plaque-destabilizing mechanical stress. Given the association between calcification morphology and cardiovascular outcomes, it... περισσότερα »
Interpretive Summaries, April 2016
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/225gV1t via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Genomic selection for tolerance to heat stress in Australian dairy cattle
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): Thuy T.T. Nguyen, Phil J. Bowman, Mekonnen Haile-Mariam, Jennie E. Pryce, Benjamin J. Hayes Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection […]
Contribution to the production of lactulose-rich whey by in situ electro-isomerization of lactose and effect on whey proteins after electro-activation as confirmed by matrix-assisted laser desorption/ionization time-of-flight-mass spectrometry and sodium dodecyl sulfate-polyacrylamide gel electrophoresis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): Ourdia Kareb, Claude P. Champagne, Mohammed Aïder Cheese-whey, a major co-product of the dairy industry, has recently been the subject of many technological applications. We studied the bioconversion of whey into valuable bio-products such as a potential lactulose prebiotic and compounds with […]
Short communication: Serum composition of milk subjected to re-equilibration by dialysis at different temperatures, after pH adjustments
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): Zhengtao Zhao, Milena Corredig The objective of this work was to investigate the properties of casein micelles after pH adjustment and their re-equilibration to the original pH and serum composition. Re-equilibration was carried out by dialyzing against skim milk at 2 different […]
Effect of 2 different premilking teat sanitation routines on reduction of bacterial counts on teat skin of cows on commercial dairy farms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Publication date: April 2016 Source:Journal of Dairy Science, Volume 99, Issue 4 Author(s): C. Baumberger, J.F. Guarín, P.L. Ruegg Premilking teat sanitation reduces the load of bacteria on teat skin before milking and it is a fundamental practice used to ensure collection of high-quality milk. The objective of this study was to compare reduction in […]
Acute ischemic lung injury due to pulmonary vascular obstruction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 53 δευτερόλεπτα
Abstract Aim of the study We have encountered cases of a distinctive myxomatous alveolar wall thickening around pulmonary infarctions and have termed it acute ischemic lung injury (AILI). In this study we determined if pulmonary infarction is the only cause of AILI and have elucidated its histological features. Materials and Methods We examined 2941 cases […]
Assault-related facial injuries during the season of goodwill.
*Assault-related facial injuries during the season of goodwill.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 22; Authors: Islam S, Uwadiae N, Hayter JP Abstract OBJECTIVE: The aim of this study was to assess if the "season of goodwill," over the 12 days of Christmas, manifests in a reduction in the rate of maxillofacial injuries secondary to interpersonal violence. STUDY DESIGN: We performed a retrospective analysis at a teaching hospital in the United Kingdom. We identified consecutive patients presenting at our institution with facial injuries secondary to assault during...περισσότερα »
Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the Guy's and St Thomas' Head and Neck Cancer Unit experience.
*Osteoradionecrosis following treatment for head and neck cancer and the effect of radiotherapy dosimetry: the Guy's and St Thomas' Head and Neck Cancer Unit experience.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 14; Authors: De Felice F, Thomas C, Patel V, Connor S, Michaelidou A, Sproat C, Kwok J, Burke M, Reilly D, McGurk M, Simo R, Lyons A, Oakley R, Jeannon JP, Lei M, Urbano TG Abstract OBJECTIVES: To analyze clinical features, dosimetric parameters, and outcomes of osteoradionecrosis (ORN). STUDY DESIGN: Thirty-six patients with ORN who had been previously treated...περισσότερα »
Letter to the Editor: A Response to Robinson (2016)
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): W.R. Lamberson from Pharmacology via ola Kala on Inoreader http://ift.tt/1W50SRv via IFTTT
Interpretive Summaries, April 2016
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 from Pharmacology via ola Kala on Inoreader http://ift.tt/225gV1t via IFTTT
Genomic selection for tolerance to heat stress in Australian dairy cattle
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): Thuy T.T. Nguyen, Phil J. Bowman, Mekonnen Haile-Mariam, Jennie E. Pryce, Benjamin J. Hayes Temperature and humidity levels above a certain threshold decrease milk production in dairy cattle, and genetic variation is associated with the amount of lost production. To enable selection for improved heat tolerance, the aim of this study was to develop genomic estimated breeding values (GEBV) for heat tolerance in dairy cattle. Heat tolerance was defined as the rate of decline in production unde...περισσότερα »
Contribution to the production of lactulose-rich whey by in situ electro-isomerization of lactose and effect on whey proteins after electro-activation as confirmed by matrix-assisted laser desorption/ionization time-of-flight-mass spectrometry and sodium dodecyl sulfate-polyacrylamide gel electrophoresis
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): Ourdia Kareb, Claude P. Champagne, Mohammed Aïder Cheese-whey, a major co-product of the dairy industry, has recently been the subject of many technological applications. We studied the bioconversion of whey into valuable bio-products such as a potential lactulose prebiotic and compounds with antioxidant properties. This paper examines efficiency, safety, and economics of electro-activation as an eco-friendly technology for a maximum valorization of whey. Thus, a bottom-up approach was ther...περισσότερα »
Short communication: Serum composition of milk subjected to re-equilibration by dialysis at different temperatures, after pH adjustments
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): Zhengtao Zhao, Milena Corredig The objective of this work was to investigate the properties of casein micelles after pH adjustment and their re-equilibration to the original pH and serum composition. Re-equilibration was carried out by dialyzing against skim milk at 2 different temperatures (4 or 22°C). Turbidity, the average radius of the casein micelles, and the composition of the soluble phase were measured at different pH values, ranging between 5.5 and 8. Acidification led to the solub... περισσότερα »
Effect of 2 different premilking teat sanitation routines on reduction of bacterial counts on teat skin of cows on commercial dairy farms
Publication date: April 2016 *Source:*Journal of Dairy Science, Volume 99, Issue 4 Author(s): C. Baumberger, J.F. Guarín, P.L. Ruegg Premilking teat sanitation reduces the load of bacteria on teat skin before milking and it is a fundamental practice used to ensure collection of high-quality milk. The objective of this study was to compare reduction in bacterial populations of teat skin after premilking preparation using either predipping with 0.5% iodine followed by drying (conventional; CONV) or using a semiautomated teat scrubber that uses chlorine dioxide (TS; FutureCow, Longwood...περισσότερα »
Acute ischemic lung injury due to pulmonary vascular obstruction
Abstract Aim of the study We have encountered cases of a distinctive myxomatous alveolar wall thickening around pulmonary infarctions and have termed it acute ischemic lung injury (AILI). In this study we determined if pulmonary infarction is the only cause of AILI and have elucidated its histological features. Materials and Methods We examined 2941 cases that underwent lobectomy, surgical lung biopsies for nodular lesions, or autopsies between 1994 and 2014. Cases were divided into pulmonary infarction and non-infarction groups. The histological features of AILI sought were lobu...περισσότερα »
Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Abstract Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop because of (1) failed induction of tolerance upon initial exposure to food antigen or (2) breakdown of established tolerance to food antigen. We review current understanding of […]
Beyond appendicitis; radiologic review of unusual and rare pathology of the appendix.
*Beyond appendicitis; radiologic review of unusual and rare pathology of the appendix.* Abdom Radiol (NY). 2016 Mar;41(3):568-581 Authors: Hines JJ, Paek GK, Lee P, Wu L, Katz DS Abstract Appendicitis is a very common cause of acute abdominal pathology, however, many other pathologic conditions of the appendix can be diagnosed utilizing CT. Examples of these conditions include primary appendiceal neoplasms, secondary inflammation of the appendix, stump appendicitis, endometriosis, appendicitis within a hernia, appendiceal diverticulosis and intussusception and intraluminal foreig... περισσότερα »
Transarterial Radioembolization with Yttrium-90 for the Treatment of Hepatocellular Carcinoma.
*Transarterial Radioembolization with Yttrium-90 for the Treatment of Hepatocellular Carcinoma.* Adv Ther. 2016 Apr 2; Authors: Kallini JR, Gabr A, Salem R, Lewandowski RJ Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is a common cause of worldwide mortality. Transarterial radioembolization (TARE) with yttrium-90 (Y90), a transcatheter intra-arterial procedure performed by interventional radiology, has become widely utilized in managing HCC. METHODS: The following is a focused review of TARE covering its commercially available products, clinical considerations of treatment, ...περισσότερα »
Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.
*Immunotherapy in gastrointestinal cancer: Recent results, current studies and future perspectives.* Eur J Cancer. 2016 Mar 31;59:160-170 Authors: Moehler M, Delic M, Goepfert K, Aust D, Grabsch HI, Halama N, Heinrich B, Julie C, Lordick F, Lutz MP, Mauer M, Alsina Maqueda M, Schild H, Schimanski CC, Wagner AD, Roth A, Ducreux M Abstract The new therapeutic approach of using immune checkpoint inhibitors as anticancer agents is a landmark innovation. Early studies suggest that immune checkpoint inhibition might also be effective in patients with gastrointestinal cancer. To improve...περισσότερα »
Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors.
*Pattern of recurrence of nonsyndromic keratocystic odontogenic tumors.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 29; Authors: Berge TI, Helland SB, Sælen A, Øren M, Johannessen AC, Skartveit L, Grung B Abstract OBJECTIVE: To describe and analyze recurrent pattern of KOTs according to time. STUDY DESIGN: This retrospective chart study evaluated histologically confirmed nonsyndromic keratocystic odontogenic tumors (KOT) treated at our institutions between 1975 and 2012. RESULTS: Mean age at time of diagnosis was 48 years, and male/female ratio was 1.8:1. The typical non...περισσότερα »
Assessment of furcal perforations in the vicinity of different root canal sealers using a cone beam computed tomography system with and without the application of artifact reduction mode: an ex vivo investigation on extracted human teeth.
*Assessment of furcal perforations in the vicinity of different root canal sealers using a cone beam computed tomography system with and without the application of artifact reduction mode: an ex vivo investigation on extracted human teeth.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 21; Authors: Kamburoğlu K, Yılmaz F, Yeta EN, Özen D Abstract OBJECTIVE: To investigate observer ability to diagnose ex vivo simulated endodontic furcal perforations in root-filled teeth from cone beam computed tomography (CBCT) images using different artifact reduction algorithms. STUDY DESI...περισσότερα »
Inherent physical characteristics and gene expression differences between alveolar and basal bones.
*Inherent physical characteristics and gene expression differences between alveolar and basal bones.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 21; Authors: Zakhary I, Alotibi F, Lewis J, ElSalanty M, Wenger K, Sharawy M, Messer RL Abstract OBJECTIVES: The objective of this study was to evaluate the baseline differences between alveolar and basal areas of the rat mandible. STUDY DESIGN: Rat mandibular alveolar and basal bones were evaluated using histology and micro-computed tomography to compare osteocyte number as well as bone density and architecture and polymerase c...περισσότερα »
Primary mucosal melanoma of the oral cavity: current therapy and future directions.
*Primary mucosal melanoma of the oral cavity: current therapy and future directions.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Jan 14; Authors: Chatzistefanou I, Kolokythas A, Vahtsevanos K, Antoniades K Abstract BACKGROUND: Primary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas (OMMs) and provide a review of the literature with regard to treatment guidelines for and prognosis of this pathologic entity. STUDY DESIGN: We report three cases of OMMs treated...περισσότερα »
A role for TENM1 mutations in Congenital General Anosmia
Abstract Congenital general anosmia (CGA) is a neurological disorder entailing a complete innate inability to sense odors. While the mechanisms underlying vertebrate olfaction have been studied in detail, there are still gaps in our understanding of the molecular genetic basis of innate olfactory disorders. Applying whole-exome sequencing to a family multiply affected with CGA, we identified three members with a rare X-linked missense mutation in the *TENM1* (*teneurin 1*) gene (ENST00000422452:c.C4829T). In *Drosophila melanogaster, TENM1* functions in synaptic-partner-matching be...περισσότερα »
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