- FDA approves first blood test to detect gene mutation associated with non-small cell lung cancerJune 1, 2016 -- The U.S. Food and Drug Administration today approved the cobas EGFR Mutation Test v2, a blood-based companion diagnostic for the cancer drug Tarceva (erlotinib). This is the first FDA-approved, blood-based genetic test that can...
from Therapeutics via xlomafota13 on Inoreader http://ift.tt/1TQP2M1 - OtoRhinoLaryngology & Medicine,New Articles,June 2nd,2016
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Abstract Background Multi-walled carbon nanotubes (MWCNT) are currently under intense toxicological investigation due to concern on their potential health effects. Current in vitro and in vivo data indicate that MWCNT exposure is strongly associated with lung toxicity (inflammation, fibrosis, granuloma,...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Abstract Background Although fishers’ knowledge has been recently considered into management programmes, there is still the need to establish a better understanding of fishers’ perceptions and cognition. Fishers can provide novel information on the biology and ecology of species, which can potentially...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Abstract Background The aim of the study was to investigate knowledge and use of wild food plants and fungi in a highland valley in the Gannan Tibetan Autonomous Region on the north-eastern edges of the Tibetan Plateau. Methods Field research was carried out in four neighbouring villages in a mountain...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Trauma, infection and cancer can cause severe scrotal defects. The demand to a definitive reconstruction in terms of aesthetics and function is high. Primary closure, skin grafts and local fasciocutaneous flaps do not meet these high demands in most cases. The authors treated a series of patients requiring...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Surgical excision of non-melanoma skin cancers is the mainstay of treatment, and a common procedure performed by clinicians from various backgrounds and training levels. Despite efforts to excise squamous cell carcinomas (SCCs) with a margin of normal tissue, some tumours are incompletely excised or...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Purpose Four US National Clinical Trials Network components (Southwest Oncology Group, Cancer and Leukemia Group B/Alliance, Eastern Cooperative Oncology Group, and the AIDS Malignancy Consortium) conducted a phase II Intergroup clinical trial that used early interim fluorodeoxyglucose positron emission...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Abstract Early brain injury (EBI) is a major cause of mortality from subarachnoid hemorrhage (SAH). We aimed to study the pathophysiology of EBI and explore the role of hepcidin, a protein involved in iron homeostatic regulation, and its downstream proteins. One hundred and thirty-two male Sprague–Dawley...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Precision medicine focuses on the management of individual patients on the basis of biomarkers and other distinguishing characteristics, with the overarching objective of improving clinical outcomes. The rapid proliferation of biomarker tests and targeted therapies has revolutionized patient care in...Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20U5Z70 via IFTTTMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1XQDHec via IFTTT
OtoRhinoLaryngology - Alexandros G. SfakianakisThe Future of Fractional Lasers: Facial plast Surg 2016; 32: 261-268DOI: 10.1055/s-0036-1584215Recent insights to the potential of fractional skin treatments have established standard laser procedures to treat aged, sun-damaged skin and scars. On top of this, the concept has been extended to fibrosing...OtoRhinoLaryngology - Alexandros G. SfakianakisSouth Indian Woman's Nose: Facial plast Surg 2016; 32: 304-308DOI: 10.1055/s-0036-1581140The normal values of nasal dimensions and position have been established for various racial and ethnic groups. Unfortunately, there is a dearth of information related to these values in South Indian females, leading...OtoRhinoLaryngology - Alexandros G. Sfakianakis: A Review: Facial plast Surg 2016; 32: 253-260DOI: 10.1055/s-0036-1582234Rejuvenative procedures of the face are increasing in numbers, and a plethora of different therapeutic options are available today. Every procedure should aim for the patient's safety first and then for natural and long-lasting...OtoRhinoLaryngology - Alexandros G. Sfakianakisin Asian Patients: Facial plast Surg 2016; 32: 315-319DOI: 10.1055/s-0036-1579783Cosmesis is paramount in the reconstruction of small nasal defects. Yotsuyanagi et al have previously described nasal aesthetic subunits in patients of Asian descent and their implications for reconstruction of large nasal...OtoRhinoLaryngology - Alexandros G. Sfakianakisas Popular Medicine in Days Gone By: Facial plast Surg 2016; 32: 245-252DOI: 10.1055/s-0036-1583852Throughout the ages, people yearned for beauty and longevity. This article examines how European physicians began to engage with the field of cosmetics over a century ago, thus introducing the category...OtoRhinoLaryngology - Alexandros G. SfakianakisA population-based study: BackgroundAlthough probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in...OtoRhinoLaryngology - Alexandros G. Sfakianakis- A multimodal MRI study: BackgroundNeuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders.MethodsIn this cross-sectional study, we investigated functional connectivity...OtoRhinoLaryngology - Alexandros G. SfakianakisLong-term occipital nerve stimulation for drug-resistant chronic cluster headache: IntroductionChronic cluster headache is rare and some of these patients become drug-resistant. Occipital nerve stimulation has been successfully employed in open studies to treat chronic drug-resistant cluster headache....OtoRhinoLaryngology - Alexandros G. SfakianakisEthnic Considerations in Facial Plastic Surgery: Facial plast Surg 2016; 32: 329-329DOI: 10.1055/s-0036-1583762Roxana Cobo, ed. Ethnic Considerations in Facial Plastic Surgery. New York, NY: Thieme Medical Publishers; 2015 (400 pages; 500 illustrations). ISBN: 978-1-626230-23-1.When I was first asked...OtoRhinoLaryngology - Alexandros G. SfakianakisLaryngeal myofascial pain syndrome as a new diagnostic entity of dysphonia: To consider the feasibility of diagnosing intrinsic laryngeal muscle myofascial pain syndrome (MPS) in dysphonic patients who demonstrated immediate symptom and stroboscopic finding improvement after laryngeal electromyography...OtoRhinoLaryngology - Alexandros G. SfakianakisTransposition of lingual thyroid gland to the submandibular region by transoral approach: The purpose of this case report is to demonstrate surgical technique of only functional but symptomatic lingual thyroid gland transposition to submandibular region by transoral approach without mandibulotomy and...OtoRhinoLaryngology - Alexandros G. SfakianakisEndoscopic cartilage butterfly myringoplasty in children: The present study evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media.AbstractObjectiveThe present study evaluated the results of the graft...OtoRhinoLaryngology - Alexandros G. SfakianakisComplications of otitis media – a potentially lethal problem still presentvia ScienceDirect Publication: Brazilian Journal of OtorhinolaryngologyPublication date: June 2016Source:Brazilian Journal of Otorhinolaryngology, Volume 82, Issue 3Author(s): Norma de Oliveira Penido, Sujana Sreedevi Chandrasekhar,...
Cancer by Sfakianakis G.Alexandrosfrom Cancer via xlomafota13 on Inoreader http://ift.tt/1TQQLRn via IFTTTCancer by Sfakianakis G.AlexandrosAbstract National Comprehensive Care Network guidelines for adjuvant treatment of invasive breast cancer are based on HER2 and hormone receptor (HR) status, where HR+ disease encompasses all estrogen receptor (ER)+ and/or progesterone receptor (PR)+ tumors. We sought to explore clinical and demographic...Cancer by Sfakianakis G.AlexandrosAbstract Glioblastoma is the most common malignant brain tumor in adults. Baseline health-related quality of life (HRQoL) is a major subject of concern for these patients. We aimed to assess the independent prognostic value of HRQoL in unresectable glioblastoma (UGB) patients for death risk stratification....
OtoRhinoLaryngology by Alexandros G.SfakianakisBackground Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders. Methods In this cross-sectional study, we investigated functional connectivity (FC) with...OtoRhinoLaryngology by Alexandros G.SfakianakisBackground Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population....OtoRhinoLaryngology by Alexandros G.SfakianakisBackground Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine...OtoRhinoLaryngology by Alexandros G.SfakianakisPediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1XiTm7S via IFTTTOtoRhinoLaryngology - Alexandros G. Sfakianakis: Demographic and geographic variation in the USvia International Journal of Pediatric OtorhinolaryngologyPublication date: August 2016Source:International Journal of Pediatric Otorhinolaryngology, Volume 87Author(s): Jonathan A. Harounian, Eric Schaefer, Jane Schubart, Michele M. CarrObjectiveTo examine...OtoRhinoLaryngology by Alexandros G.SfakianakisA 34-YEAR-OLD WOMAN sought consultation at our clinic for an asymptomatic swelling on her right foot that had been growing very slowly over the last 15 years. She said she had presented to other... from #ENT via xlomafota13 on Inoreader http://ift.tt/1XQZSB2 via IFTTTOtoRhinoLaryngology by Alexandros G.SfakianakisA PREVIOUSLY HEALTHY 32-YEAR-OLD MAN presented to the emergency room with a persistent, nonpruritic rash on his trunk, which had suddenly appeared 2 days after he ate Chinese food. Physical... from #ENT via xlomafota13 on Inoreader http://ift.tt/1UvKWG0 via IFTTTOtoRhinoLaryngology by Alexandros G.SfakianakisPediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1XReznT via IFTTTOtoRhinoLaryngology by Alexandros G.SfakianakisThe T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6'-dibehenate (TDB) has raised interest in development of synthetic...OtoRhinoLaryngology by Alexandros G.SfakianakisPhosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a), which dephosphorylates PtdIns(3,4)P2 to PtdIns(3)P, in bacterial...OtoRhinoLaryngology by Alexandros G.SfakianakisNeonatal innate immunity is distinct from that of adults, which may contribute to increased susceptibility to infection and limit vaccine responses. B cells play critical roles in protection from infection and detect PAMPs via TLRs, that, when co-activated with CD40, can drive B-cell proliferation and...OtoRhinoLaryngology - Alexandros G. SfakianakisFehlbehandlung mit injizierbaren Fillern: ZusammenfassungInjizierbare Filler sind ein wichtiger Bestandteil der ästhetischen Dermatologie. Sie dienen dazu, die Hautstruktur zu stärken, Fältchen/Falten und/oder Volumen auszugleichen. Vereinfacht lässt sich der Markt auf die abbaubaren Präparate, v. a....OtoRhinoLaryngology - Alexandros G. SfakianakisThe butterfly in the neck:Tiny NairThyroid Research and Practice 2016 13(2):98-98He felt weak and tired at the end of the day“Its office stress;” he shrugged awayLeg cramp, backache, drowsy feel“Bad office chair;” no big dealItchy thick skin, putting on weight“Allergy and obesity is a family trait”Dozing...OtoRhinoLaryngology - Alexandros G. SfakianakisConservatively managed thyroglossal duct cyst carcinoma with lymph node metastasis: Long-term result: Ilker Burak Arslan, Ahmet Tugrul Eruyar, Murat Gumussoy, Selahattin GencThyroid Research and Practice 2016 13(2):77-79Thyroid papillary carcinomas of thyroglossal duct cysts (TGDCs) are quite uncommon....OtoRhinoLaryngology - Alexandros G. SfakianakisThyroid ectopia is distinctly uncommon in Indian children with permanent congenital hypothyroidism due to dysgenetic glands: Devi DayalThyroid Research and Practice 2016 13(2):94-95Sir,The recent article by Patil et al. made for an interesting read.[1] Their case series on ectopic thyroid gland (ETG)...
OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOPediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1XiTm7S from on Inoreader http://ift.tt/1Y3JSfB via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOPublication date: Available online 1 June 2016Source:Allergology International Author(s): Masanari Watanabe, Hisashi Noma, Jun Kurai, Hiroyuki Sano, Degejirihu Hantan, Masaru Ueki, Hiroya Kitano, Eiji Shimizu BackgroundThe relationship between airborne particulate matter (PM) and pulmonary function...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOA 34-YEAR-OLD WOMAN sought consultation at our clinic for an asymptomatic swelling on her right foot that had been growing very slowly over the last 15 years. She said she had presented to other… from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1XQZSB2 from on Inoreader http://ift.tt/1Y3Iv0g...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOA PREVIOUSLY HEALTHY 32-YEAR-OLD MAN presented to the emergency room with a persistent, nonpruritic rash on his trunk, which had suddenly appeared 2 days after he ate Chinese food. Physical… from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1UvKWG0 from on Inoreader http://ift.tt/1sNU7bM...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOPediatric Allergy, Immunology, and Pulmonology , Vol. 0, No. 0. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1XReznT from on Inoreader http://ift.tt/1Y3JbCM via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOThe T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6’-dimycolate (TDM) is well established. The identification of the C-type lectin Mincle on innate immune cells as the receptor for TDM and its synthetic analogue trehalose 6,6’-dibehenate (TDB) has raised interest in development of synthetic...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOPhosphatidylinositol 3-kinase (PI3K)/Akt signaling has been implicated in the anti-inflammatory response in a mouse model of endotoxemia and sepsis. The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a), which dephosphorylates PtdIns(3,4)P2 to PtdIns(3)P, in bacterial...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEONeonatal innate immunity is distinct from that of adults, which may contribute to increased susceptibility to infection and limit vaccine responses. B cells play critical roles in protection from infection and detect PAMPs via TLRs, that, when co-activated with CD40, can drive B-cell proliferation and...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOPublication date: Available online 1 June 2016Source:Allergology International Author(s): Masanari Watanabe, Hisashi Noma, Jun Kurai, Hiroyuki Sano, Degejirihu Hantan, Masaru Ueki, Hiroya Kitano, Eiji Shimizu BackgroundThe relationship between airborne particulate matter (PM) and pulmonary function...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOThyroid , Vol. 0, No. 0. from http://ift.tt/1WxEthp via IFTTT from on Inoreader http://ift.tt/1UvLhbM via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS Srikanth Thyroid Research and Practice 2016 13(2):95-97 from http://ift.tt/1ROVvzl via IFTTT from on Inoreader http://ift.tt/1XiQLe1 via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEORicha Bhartiya, Mahasweta Mallik, Nawanita Kumari, Manish Kumar Thyroid Research and Practice 2016 13(2):86-88 Filariasis is a major public health problem in tropical countries including India. About 90% of cases of lymphatic filariasis are caused by infection with Wuchereria bancrofti and rest by...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOShrikant Somani, Narendra Kotwal Thyroid Research and Practice 2016 13(2):52-56 Fine needle aspiration cytology (FNAC) is considered to be most effective and accurate diagnostic test to differentiate benign from malignant thyroid nodules and most guidelines recommend FNAC as the initial test. However,...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOMadhu Kumar, Aakanksha Singh, Sanjeev Mishra Thyroid Research and Practice 2016 13(2):80-82 The scalp metastasis of follicular thyroid carcinoma is a rare condition and the lesion should be differentiated from primary skin tumors. It account for 10–20% of all thyroid malignancies and is most commonly...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOSrinivas Sidduri, Babulreddy Hanmayyagari, Vivekanand Bongi, Mythili Ayyagari, Subramanyam Venkata Thyroid Research and Practice 2016 13(2):57-62 Background: Hypothyroidism affects bile content, bile flow, and functions of the sphincter of Oddi, thereby increases the formation of common bile duct (CBD)...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOArvind Krishnamurthy Thyroid Research and Practice 2016 13(2):92-94 from http://ift.tt/1WZAcTP via IFTTT from on Inoreader http://ift.tt/1UvLprN via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOAmresh Shrivastava, Vidya Jadhav, Sagar Karia, Nilesh Shah, Avinash De Sousa Thyroid Research and Practice 2016 13(2):63-66 Background: Neuroendocrine hormones play an important role in emotional regulation in normal individuals and those suffering from mental disorders. The objective of the study...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOArun Kumar, Sanjay Kalra, AG Unnikrishnan Thyroid Research and Practice 2016 13(2):49-51 from http://ift.tt/1WZzPsq via IFTTT from on Inoreader http://ift.tt/1UvLFa2 via IFTTTOTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEODevi Dayal, Nirmal Hansdak, Dharam Vir, Atul Gupta, Jaimanti Bakshi Thyroid Research and Practice 2016 13(2):67-70 Background: There is an increased risk of hearing impairment in permanent congenital hypothyroidism (CH). Only a few studies have explored the prevalence of hearing impairment in CH and...OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOSapna Erat Sreedharan, Pragati Agrawal, Ashalatha Radhakrishnan Thyroid Research and Practice 2016 13(2):83-85 Obstructive sleep apnea (OSA) has been reported with untreated hypothyroidism. Here, we report a young patient referred to us due to prolonged apneas detected during recovery from minor surgery...OtoRhinoLaryngology - Alexandros G. SfakianakisA case report of a very rare entity: Anil Taneja, Sonal Sethi, Bindu Kulshreshtha, Imroz SachdevThyroid Research and Practice 2016 13(2):74-76Developmental morphological abnormalities of the thyroid gland are very rare. Thyroid lobe hemiagenesis is a very rare abnormality, in which one thyroid lobe fails...
otorhinolaryngologysfakianakisIntroduction Chronic cluster headache is rare and some of these patients become drug-resistant. Occipital nerve stimulation has been successfully employed in open studies to treat chronic drug-resistant cluster headache. Data from large group of occipital nerve stimulation-treated chronic cluster headache...otorhinolaryngologysfakianakisBackground Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders. Methods In this cross-sectional study, we investigated functional connectivity (FC) with...otorhinolaryngologysfakianakisBackground Cranial autonomic parasympathetic symptoms (CAPS) appear in at least half of migraine patients theoretically as a result of the release of peptides by the trigemino-vascular system (TVS). Cranial pain pathways become sensitised by repeated episodes of TVS activation, leading to migraine chronification....otorhinolaryngologysfakianakisBackground Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population....OtoRhinoLaryngology - Alexandros G. SfakianakisDiffuse coronary vasospasm in a patient with hypothyroidism: Altug Osken, Selcuk Yaylaci, Ercan Aydin, Tugba Kemaloglu Oz, Gokturk Ipek, Isil Atasoy, Regayip Zehir, Sennur Unal DayiThyroid Research and Practice 2016 13(2):89-91Coronary vasospasm is an important etiology of ischemic heart disease. Sometimes...OtoRhinoLaryngology - Alexandros G. SfakianakisA rare thyroid neoplasm: Vinod Raosaheb Patil, Keyuri Patel, Girish MuzumdarThyroid Research and Practice 2016 13(2):71-73Carcinoma showing thymus like differentiation (CASTLE) is a rare tumor involving soft tissues of the neck and the thyroid gland. It arises from ectopic thymus or remnants of branchial...OtoRhinoLaryngology - Alexandros G. SfakianakisA rare association: Sapna Erat Sreedharan, Pragati Agrawal, Ashalatha RadhakrishnanThyroid Research and Practice 2016 13(2):83-85Obstructive sleep apnea (OSA) has been reported with untreated hypothyroidism. Here, we report a young patient referred to us due to prolonged apneas detected during recovery...OtoRhinoLaryngology - Alexandros G. SfakianakisData from Northwest India: Devi Dayal, Nirmal Hansdak, Dharam Vir, Atul Gupta, Jaimanti BakshiThyroid Research and Practice 2016 13(2):67-70Background: There is an increased risk of hearing impairment in permanent congenital hypothyroidism (CH). Only a few studies have explored the prevalence of hearing...OtoRhinoLaryngology - Alexandros G. Sfakianakisin India: Insights from National Family Health Survey-4:Arun Kumar, Sanjay Kalra, AG UnnikrishnanThyroid Research and Practice 2016 13(2):49-51The importance of iodine for thyroid health, and the role of salt iodization in achieving this, are well known.[1] In spite of multiple legislation, use of iodized... - Endoscopic cartilage butterfly myringoplasty in childrenEndoscopic cartilage butterfly myringoplasty in children: The present study evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media.
Abstract
Objective
The present study evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media.Methods
The study included 32 pediatric patients aged between 8 and 17, who had endoscopic inlay butterfly myringoplasty with the diagnosis of chronic otitis media between September 2012 and January 2015 in Elazig Training and Research Hospital Otorhinolaryngology Clinic and Firat University Otorhinolaryngology Clinic. All patients’ demographics, perforation size, and hearing status were examined.Results
Tympanic membrane perforation was ≤3 mm in 12 patients and between 3 and 6 mm in 20 patients. The air-bone gap (ABG) of the patients was 18.5 ± 6.29 dB preoperatively, 8.81 ± 3.53 dB postoperatively second month, 8.09 ± 3.55 dB postoperatively sixth month, and 7.96 ± 3.32 dB postoperatively 12th month. Two (6.3%) of the patients had postoperative myringitis. Two (6.3%) patients had recurrent perforation in the postoperative follow-ups.Conclusion
In children, endoscopic inlay butterfly tympanoplasty is a surgical technique with short duration, high graft success, effective hearing reconstruction, and high levels of postoperative patient comfort.
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via IFTTT - Intracranial complications (ICCs) of chronic and acute otitis media (COM and AOM)
Publication date: June 2016
Source:Brazilian Journal of Otorhinolaryngology, Volume 82, Issue 3
Author(s): Norma de Oliveira Penido, Sujana Sreedevi Chandrasekhar, Andrei Borin, André Souza de Albuquerque Maranhão, José Ricardo Gurgel Testa
IntroductionIt is an erroneous but commonly held belief that intracranial complications (ICCs) of chronic and acute otitis media (COM and AOM) are past diseases or from developing countries. These problems remain, despite improvements in antibiotic care.ObjectiveThis paper analyzes the occurrence and clinical characteristics and course of the main ICCs of otitis media (OM).MethodsRetrospective cohort study of 51 patients with ICCs from OM, drawn from all patients presenting with OM to the emergency room of a large inner-city tertiary care hospital over a 22-year period.Results80% of cases were secondary to COM of which the incidence of ICC was 0.8%; 20% were due to AOM. The death occurrence was 7.8%, hearing loss in 90%, and permanent neurological sequelae in 29%. Patients were 61% male. In the majority, onset of ear disease had occurred during childhood. Delay of diagnosis of both the initial infection as well as the secondary ICC was significant. ICCs included brain abscess and meningitis in 78%, and lateral sinus thrombosis, empyema and otitic hydrocephalus in 13%, 8% and 1% of cases, respectively. Twenty-seven neurosurgical procedures and 43 otologic surgery procedures were performed. Two patients were too ill for surgical intervention.ConclusionICCs of OM, although uncommon, still occur. These cases require expensive, complex and long-term inpatient treatment and frequently result in hearing loss, neurological sequelae and mortality. It is important to be aware of this potentiality in children with COM, especially, and maintain a high index of suspicion in order to refer for otologic specialty care before such complications occur.
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via IFTTT - Pediatric adenotonsillectomy and postoperative hemorrhage
Publication date: August 2016
Source:International Journal of Pediatric Otorhinolaryngology, Volume 87
Author(s): Jonathan A. Harounian, Eric Schaefer, Jane Schubart, Michele M. Carr
ObjectiveTo examine demographic and regional variations in pediatric tonsillectomy, with or without adenoidectomy, and post-tonsillectomy hemorrhage on a national level.MethodsThe MarketScan®database was analyzed for claims made between 2008–2012 for the 30 days following tonsillectomy/adenotonsillectomy in privately insured children 1–17 years of age.ResultsWe analyzed 305,860 patients with 98.6% of these tonsillectomies occurring in an ambulatory setting. Children between 3–6 years old comprised our largest group of tonsillectomies (45.1%). More tonsillectomies were done in the South (42.1%) than any other region in our sample. Patients between 11 and17 years old had the highest percentage of bleeding (4.8%). Patients between 1 and 3 years old had the lowest values. Of the 8,518 children who presented with post-operative hemorrhage, 71.7% had only one hemorrhagic event, 28.3% had at least a second one, 6.0% had at least 3 events, and 1.3% had at least 4 events. Post-operative dehydration had a similar pattern. The South had the lowest percentage of post-tonsillectomy bleeds (2.5%) and overall ER visits (7.1%), both of which were most common in the Midwest. Gender had no significant association with incidence of tonsillectomy procedures or post-op complications.ConclusionThere are geographic and demographic variations in adenotonsillectomy and in post-operative complications for children nationally.
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via IFTTT - The Future of Fractional LasersThe Future of Fractional Lasers:
Facial plast Surg 2016; 32: 261-268
DOI: 10.1055/s-0036-1584215
Recent insights to the potential of fractional skin treatments have established standard laser procedures to treat aged, sun-damaged skin and scars. On top of this, the concept has been extended to fibrosing conditions, to remove foreign bodies and to treat inflammatory skin diseases. The biggest potential, however, is foreseen with the option of a contact-free temporary opening of the epidermal barrier (TOR, German: gate) to promote new and intensified treatment regimen. To date these concepts are predominantly experimental, although first clinical studies already show a better response rate if actinic keratoses are treated by fractional laser-intensified photodynamic therapy (PDT) in comparison to the conventional PDT. Possible risks may arise due to the fact that fractional laser home devices are at hand. Used in conjunction with topicals of all origins, toxic and allergic reactions may occur. Principles of current fractional laser interventions are presented as facts while visions are given as future indications.
[…]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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via IFTTT - Anthropometric Analysis of Woman's NoseSouth Indian Woman’s Nose:
Facial plast Surg 2016; 32: 304-308
DOI: 10.1055/s-0036-1581140
The normal values of nasal dimensions and position have been established for various racial and ethnic groups. Unfortunately, there is a dearth of information related to these values in South Indian females, leading to surgeons being forced to use statistical data from Caucasians in their decision making. The objective of the present study was to compare statistically the nasal anthropometric measurement of South Indian women (SIW) with published norms for North American white women (NAWW) using independent t-test. Anthropometric analysis was done on standardized frontal, lateral, and basal photographs of South Indian woman’s noses (n = 375) ages 18 to 35 years. Comparative analysis showed significant differences between SIW and NAWW in 15 of 17 measurements. All 14 nasal indices revealed significant differences that were calculated. SIW had relatively shorter, wider, and more horizontally oriented noses, and the noses have ellipsoid appearance in submental view, deeper nasal root, underrotated nasal tip, flared alae, and rounded nasal tip. As cosmetic surgery becomes more popular among South Indians, the obtained normative mean values might serve as a prototype for facial surgery.
[…]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sNY3JB
via IFTTT - The Anatomy of the Aging Face: A Review:
Facial plast Surg 2016; 32: 253-260
DOI: 10.1055/s-0036-1582234
Rejuvenative procedures of the face are increasing in numbers, and a plethora of different therapeutic options are available today. Every procedure should aim for the patient’s safety first and then for natural and long-lasting results. The face is one of the most complex regions in the human body and research continuously reveals new insights into the complex interplay of the different participating structures. Bone, ligaments, muscles, fat, and skin are the key players in the layered arrangement of the face.Aging occurs in all involved facial structures but the onset and the speed of age-related changes differ between each specific structure, between each individual, and between different ethnic groups. Therefore, knowledge of age-related anatomy is crucial for a physician’s work when trying to restore a youthful face.This review focuses on the current understanding of the anatomy of the human face and tries to elucidate the morphological changes during aging of bone, ligaments, muscles, and fat, and their role in rejuvenative procedures.
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via IFTTT - V-Y Advancement Flaps Based on Yotsuyanagi Aesthetic Subunit Principles for Small Nasal Defectsin Asian Patients:
Facial plast Surg 2016; 32: 315-319
DOI: 10.1055/s-0036-1579783
Cosmesis is paramount in the reconstruction of small nasal defects. Yotsuyanagi et al have previously described nasal aesthetic subunits in patients of Asian descent and their implications for reconstruction of large nasal defects, including forehead flap and Z-plasty. The impact of Asian skin types and aesthetic subunits on reconstruction planning of small nasal defects has not been rigorously explored. The aim of this article is to present a novel method for repairing small nose defects in patients of Asian descent using V-Y advancement flap designed using Yotsuyanagi nasal subunit aesthetic principles. A total of 21 defects ranging from 7 to 22 mm in size in 21 patients of Asian descent were repaired with either 1 or 2 V-Y advancement flaps designed along Yotsuyanagi nasal subunit borders. All reconstructions were completed successfully in one stage. Scars were inconspicuous and nasal subunits were neither displaced nor twisted. All patients were pleased with the cosmetic outcomes. The use of V-Y advancement flaps based on Asian aesthetic nasal subunit principles for the reconstruction of small nasal defects is a novel, cosmetically sensitive alternative.
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via IFTTT - Cosmetic Medicine: Innovative Beauty Careas Popular Medicine in Days Gone By:
Facial plast Surg 2016; 32: 245-252
DOI: 10.1055/s-0036-1583852
Throughout the ages, people yearned for beauty and longevity. This article examines how European physicians began to engage with the field of cosmetics over a century ago, thus introducing the category of aesthetics into medical practice. This historical phenomenon is currently repeating itself.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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via IFTTT - Pain modulation is affected differently in medication-overuse headache and chronic myofascial pain- A multimodal MRI study: Background
Neuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders.
Methods
In this cross-sectional study, we investigated functional connectivity (FC) with resting-state functional magnetic resonance imaging (fMRI) and white matter integrity using diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) and mean diffusivity (MD) in patients with MOH (N = 12) relative to two control groups: patients with chronic myofascial pain (MYO; N = 11) and healthy controls (CN; N = 16).
Results
In a data-driven approach we found hypoconnectivity in the fronto-parietal attention network in both pain groups relative to CN (i.e. MOH < CN and MYO < CN). In contrast, hyperconnectivity in the saliency network (SN) was detected only in MOH, which correlated with FA in the insula. In a seed-based analysis we investigated FC between the periaqueductal grey (PAG) and all other brain regions. In addition to overlapping hyperconnectivity seen in patient groups (relative to CN), MOH had a distinct connectivity pattern with lower FC to parieto-occipital regions and higher FC to orbitofrontal regions compared to controls. FA and MD abnormalities were mostly observed in MOH, involving the insula.
Conclusions
Hyperconnectivity within the SN along with associated white matter changes therein suggest a particular role of this network in MOH. In addition, abnormal connectivity between the PAG and other pain modulatory (frontal) regions in MOH are consistent with dysfunctional central pain control.
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via IFTTT - Anxiety and depression in probable migraine:A population-based study: Background
Although probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population.
Methods
We recruited Korean individuals aged 19–69 years via stratified random sampling and assessed headache type, anxiety, and depression among them using structured interviews.
Results
In a representative sample of 2695 individuals, 143 (5.3%) and 379 (14.1%) had migraine and PM, respectively. Fewer patients with PM had anxiety (17.7% vs. 30.1%, p = 0.002) and depression (8.7% vs. 16.8%, p = 0.007) compared to those with migraine. Prevalence of anxiety and depression was lower in people with PM than in those with migraine in univariable analysis, but insignificant after including headache intensity and headache frequency for adjustment. Headache frequency, headache intensity, and impact of headache were significantly higher among PM and migraine patients with anxiety and depression than among those without.
Conclusions
The prevalence of anxiety and depression was lower among individuals with PM compared to those with migraine. However, they were still prevalent and associated with an exacerbation of symptoms among individuals with PM.
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via IFTTT - Long-term occipital nerve stimulation for drug-resistant chronic cluster headacheLong-term occipital nerve stimulation for drug-resistant chronic cluster headache: Introduction
Chronic cluster headache is rare and some of these patients become drug-resistant. Occipital nerve stimulation has been successfully employed in open studies to treat chronic drug-resistant cluster headache. Data from large group of occipital nerve stimulation-treated chronic cluster headache patients with long duration follow-up are advantageous.
Patients and methods
Efficacy of occipital nerve stimulation has been evaluated in an experimental monocentric open-label study including 35 chronic drug-resistant cluster headache patients (mean age 42 years; 30 men; mean illness duration: 6.7 years). The primary end-point was a reduction in number of daily attacks.
Results
After a median follow-up of 6.1 years (range 1.6–10.7), 20 (66.7%) patients were responders (≥50% reduction in headache number per day): 12 (40%) responders showed a stable condition characterized by sporadic attacks, five responders had a 60–80% reduction in headache number per day and in the remaining three responders chronic cluster headache was transformed in episodic cluster headache. Ten (33.3%) patients were non-responders; half of these have been responders for a long period (mean 14.6 months; range 2–48 months). Battery depletion (21 patients 70%) and electrode migration (six patients – 20%) were the most frequent adverse events.
Conclusions
Occipital nerve stimulation efficacy is confirmed in chronic drug-resistant cluster headaches even after an exceptional long-term follow-up. Tolerance can occur years after improvement.
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via IFTTT - Ethnic Considerations in Facial Plastic SurgeryEthnic Considerations in Facial Plastic Surgery:
Facial plast Surg 2016; 32: 329-329
DOI: 10.1055/s-0036-1583762
Roxana Cobo, ed. Ethnic Considerations in Facial Plastic Surgery. New York, NY: Thieme Medical Publishers; 2015 (400 pages; 500 illustrations). ISBN: 978-1-626230-23-1.
When I was first asked to contribute a chapter on Asian rhinoplasty for Dr. Cobo’s Ethnic Considerations in Facial Plastic Surgery, I could not figure out what this book would look like. However, when I received my author’s copy of this book, I was stunned and fascinated at the thoughtfully constructed structure and the depth of the scientific contents of this book, and I realized that Dr. Cobo had accomplished a monumental task for facial plastic surgery teaching. To my knowledge, this is the first book on facial plastic surgery that is truly devoted to the better in-depth teaching on the different aspects of facial plastic surgery pertaining to different patient groups in this globalized and multicultural 21st century.
This book comprises 32 chapters, which are nicely written in terms of their relevance and depth. This book contains four important ethnic sections: the Latin American/mestizo patient, the African patient, the Asian patient, and the Mediterranean and Middle Eastern patient. Each section includes important aspects of the aesthetic, ethnic, and cultural considerations of each group. In addition, each section contains the most up-to-date issues that are the hot topics in facial plastic surgery in each specific regional area. Dr. Cobo invited the very best authors who are recognized experts and who can deliver up-to-date information in each specific field of ethnic facial plastic surgery. I especially liked the section on African patients, because I had never read a reference with such a degree of comprehensiveness as this one. As a specialist in Asian rhinoplasty, I very much enjoyed the depth of scientific contents of The Asian section, which truly highlighted the most important and contemporary issues in Asian facial plastic surgery. This text offers 1,083 illustrations and access to 31 video clips; the illustrations are beautifully drawn, and both clinical and intraoperative photographs are high quality and exemplary, and the video clips are clear and instructive. Owing to its logical and practical organization, the reader will easily find relevant information that is helpful for optimally managing his or her target patients. I can dare to testify that no other reference so far dealt with issues related to ethnic facial plastic surgery as comprehensive as this book.
In conclusion, Dr. Cobo’s Ethnic Considerations in Facial Plastic Surgery is a masterpiece and, without a doubt, one of the best single-volume books available on the ethnic aspects of facial plastic surgery. I strongly recommend this beautiful book as a perfect reference for the facial plastic surgeon who wants to have global view on facial plastic surgery.
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
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via IFTTT - Intrinsic laryngeal muscle myofascial pain syndrome (MPS) in dysphonic patientsLaryngeal myofascial pain syndrome as a new diagnostic entity of dysphonia: To consider the feasibility of diagnosing intrinsic laryngeal muscle myofascial pain syndrome (MPS) in dysphonic patients who demonstrated immediate symptom and stroboscopic finding improvement after laryngeal electromyography (LEMG) without further treatment.
Abstract
Objective
To consider the feasibility of diagnosing intrinsic laryngeal muscle myofascial pain syndrome (MPS) in dysphonic patients who demonstrated immediate symptom and stroboscopic finding improvement after laryngeal electromyography (LEMG) without further treatment.Methods
A chart review of patients who showed subtle vocal fold movement abnormalities on a stroboscopic examination and underwent ultrasonography (US)-guided LEMG was performed. Patients with vocal fold paralysis, mucosal lesions, spasmodic dysphonia, and vocal tremor on stroboscopic examination were excluded. Among them, patients with normal EMG findings were included in this study. The patients who reported voice symptom improvement after LEMG without further treatment were placed in laryngeal MPS (LMPS) group and the other patients were placed in non-laryngeal MPS (non-MPS) group. Predisposing factors, voice symptom, symptom-duration, and stroboscopic findings of these patients were reviewed.Results
Among the 16 patients, LEMG findings were normal, five (31%) were included in the LMPS group and the other 11 patients (69%) were included in the non-MPS group. All LMPS group patients had a history of voice abuse and reported odynophonia. The Korean Voice Handicap Index-10 score decreased significantly after US-guided LEMG without additional treatment in the LMPS group. The stroboscopic findings revealed that vocal fold hypomobility was the most common finding in the LMPS group, and two patients showed a muscle tension dysphonia pattern. The LMPS groups showed improvement of vocal fold mobility on 1-week stroboscopic evaluation.Conclusion
LMPS is a potential diagnosis for patients with vocal fold hypomobility finding on stroboscopic findings but with normal EMG results. Diagnosis of LMPS could be considered in patients who showed symptom and vocal fold movement improvement after LEMG.
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via IFTTT - Transposition of lingual thyroid gland to the submandibular region by transoral approachTransposition of lingual thyroid gland to the submandibular region by transoral approach: The purpose of this case report is to demonstrate surgical technique of only functional but symptomatic lingual thyroid gland transposition to submandibular region by transoral approach without mandibulotomy and tongue-splitting.A 37-year-old female patient was admitted to our hospital with dysphagia and apnea symptoms. Physical examination revealed 3cm×3cm lingual thyroid gland was detected at the tongue base. The patient was euthyroid and thyroid gland was not detected in the neck. Under general anesthesia, right submandibular gland excision and transposition of lingual thyroid tissue to submandibular region with dorsal lingual artery axis flap were performed by transoral approach.
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via IFTTT - Endoscopic cartilage butterfly myringoplasty in childrenEndoscopic cartilage butterfly myringoplasty in children: The present study evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media.
Abstract
Objective
The present study evaluated the results of the graft success rate and hearing gain of children who underwent endoscopic inlay butterfly myringoplasty due to chronic otitis media.Methods
The study included 32 pediatric patients aged between 8 and 17, who had endoscopic inlay butterfly myringoplasty with the diagnosis of chronic otitis media between September 2012 and January 2015 in Elazig Training and Research Hospital Otorhinolaryngology Clinic and Firat University Otorhinolaryngology Clinic. All patients’ demographics, perforation size, and hearing status were examined.Results
Tympanic membrane perforation was ≤3 mm in 12 patients and between 3 and 6 mm in 20 patients. The air-bone gap (ABG) of the patients was 18.5 ± 6.29 dB preoperatively, 8.81 ± 3.53 dB postoperatively second month, 8.09 ± 3.55 dB postoperatively sixth month, and 7.96 ± 3.32 dB postoperatively 12th month. Two (6.3%) of the patients had postoperative myringitis. Two (6.3%) patients had recurrent perforation in the postoperative follow-ups.Conclusion
In children, endoscopic inlay butterfly tympanoplasty is a surgical technique with short duration, high graft success, effective hearing reconstruction, and high levels of postoperative patient comfort.
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via IFTTT - Intracranial complications (ICCs) of chronic and acute otitis media (COM and AOM)
Publication date: June 2016
Source:Brazilian Journal of Otorhinolaryngology, Volume 82, Issue 3
Author(s): Norma de Oliveira Penido, Sujana Sreedevi Chandrasekhar, Andrei Borin, André Souza de Albuquerque Maranhão, José Ricardo Gurgel Testa
IntroductionIt is an erroneous but commonly held belief that intracranial complications (ICCs) of chronic and acute otitis media (COM and AOM) are past diseases or from developing countries. These problems remain, despite improvements in antibiotic care.ObjectiveThis paper analyzes the occurrence and clinical characteristics and course of the main ICCs of otitis media (OM).MethodsRetrospective cohort study of 51 patients with ICCs from OM, drawn from all patients presenting with OM to the emergency room of a large inner-city tertiary care hospital over a 22-year period.Results80% of cases were secondary to COM of which the incidence of ICC was 0.8%; 20% were due to AOM. The death occurrence was 7.8%, hearing loss in 90%, and permanent neurological sequelae in 29%. Patients were 61% male. In the majority, onset of ear disease had occurred during childhood. Delay of diagnosis of both the initial infection as well as the secondary ICC was significant. ICCs included brain abscess and meningitis in 78%, and lateral sinus thrombosis, empyema and otitic hydrocephalus in 13%, 8% and 1% of cases, respectively. Twenty-seven neurosurgical procedures and 43 otologic surgery procedures were performed. Two patients were too ill for surgical intervention.ConclusionICCs of OM, although uncommon, still occur. These cases require expensive, complex and long-term inpatient treatment and frequently result in hearing loss, neurological sequelae and mortality. It is important to be aware of this potentiality in children with COM, especially, and maintain a high index of suspicion in order to refer for otologic specialty care before such complications occur.
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via IFTTT - Pain modulation is affected differently in medication-overuse headache and chronic myofascial pain - A multimodal MRI studyBackgroundNeuroimaging studies revealed structural and functional changes in medication-overuse headache (MOH), but it remains unclear whether similar changes could be observed in other chronic pain disorders.MethodsIn this cross-sectional study, we investigated functional connectivity (FC) with resting-state functional magnetic resonance imaging (fMRI) and white matter integrity using diffusion tensor imaging (DTI) to measure fractional anisotropy (FA) and mean diffusivity (MD) in patients with MOH (N = 12) relative to two control groups: patients with chronic myofascial pain (MYO; N = 11) and healthy controls (CN; N = 16).ResultsIn a data-driven approach we found hypoconnectivity in the fronto-parietal attention network in both pain groups relative to CN (i.e. MOH < CN and MYO < CN). In contrast, hyperconnectivity in the saliency network (SN) was detected only in MOH, which correlated with FA in the insula. In a seed-based analysis we investigated FC between the periaqueductal grey (PAG) and all other brain regions. In addition to overlapping hyperconnectivity seen in patient groups (relative to CN), MOH had a distinct connectivity pattern with lower FC to parieto-occipital regions and higher FC to orbitofrontal regions compared to controls. FA and MD abnormalities were mostly observed in MOH, involving the insula.ConclusionsHyperconnectivity within the SN along with associated white matter changes therein suggest a particular role of this network in MOH. In addition, abnormal connectivity between the PAG and other pain modulatory (frontal) regions in MOH are consistent with dysfunctional central pain control.
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via IFTTT - Anxiety and depression in probable migraine: A population-based studyBackgroundAlthough probable migraine (PM) is common among headache sufferers, there is little knowledge of the prevalence and impacts of comorbid anxiety and depression in patients with PM. We assessed the prevalence and impact of anxiety and depression among PM sufferers in the general population.MethodsWe recruited Korean individuals aged 19–69 years via stratified random sampling and assessed headache type, anxiety, and depression among them using structured interviews.ResultsIn a representative sample of 2695 individuals, 143 (5.3%) and 379 (14.1%) had migraine and PM, respectively. Fewer patients with PM had anxiety (17.7% vs. 30.1%, p = 0.002) and depression (8.7% vs. 16.8%, p = 0.007) compared to those with migraine. Prevalence of anxiety and depression was lower in people with PM than in those with migraine in univariable analysis, but insignificant after including headache intensity and headache frequency for adjustment. Headache frequency, headache intensity, and impact of headache were significantly higher among PM and migraine patients with anxiety and depression than among those without.ConclusionsThe prevalence of anxiety and depression was lower among individuals with PM compared to those with migraine. However, they were still prevalent and associated with an exacerbation of symptoms among individuals with PM.
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Τετάρτη 1 Ιουνίου 2016
OtoRhinoLaryngology & Medicine,New Articles,June 2nd,2016,a
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