Circulating vitamin D–binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma: A case-control study

To the Editor: Novel risk factors and biomarkers are being sought for cutaneous melanoma, given its increasing incidence and mortality worldwide. Although ultraviolet radiation is an established melanoma risk factor, paradoxically, vitamin D (VD) deficiency has been linked to increased melanoma risk and progression with conflicting results.1 A majority of 25-hydroxyvitamin D [25(OH)D] and 1,25(OH)2D circulate bound to VD-binding protein (DBP) (85%-90%) and albumin (10%-15%), with <1% circulating in its free form.

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