Expression Of Cell Cycle Proteins According To HPV Status In Oral Squamous Cell Carcinoma Affecting Young Patients: A Pilot Study

Publication date: Available online 2 February 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Marisol Miranda Galvis, Juscelino Freitas Jardim, Estela Kaminagakura, Alan Roger Santos-Silva, Felipe Paiva Fonseca, Oslei Paes Almeida, Marcio Ajudarte Lopes, Clóvis Lópes Pinto, Luiz Paulo Kowalski
ObjectiveTobacco and alcohol consumption are considered the main risk factors for oral squamous cell carcinoma (OSCC); however, the role of these factors in patients younger than 40 years is controversial, so it has been suggested that genomic instability and high-risk human papillomavirus (HR-HPV) infection may be contributing factors to oral carcinogenesis at a young age. Therefore, the aim of this study was to evaluate the immunoexpression of cell cycle proteins according HPV status in OSCC affecting young patients.MethodsA tissue microarray construction based on 34 OSCC samples from young patients (<40 years old) was subjected to immunohistochemical reactions for Ki-67, Cyclin D1, C-ErbB2, p21, Myc, EGFR, p53 and p16 antibodies.ResultsThe clinicopathological features and the immunoexpression of all tested proteins were similar in both groups. HPV-related OSSC tended to have better cancer-specific survival (39% vs 60% 5-year CSS), and overall survival (OS) (29.2% vs 60% 5-year OS). However, it were not statistically significant.ConclusionNo significant difference exists in the expression of cell cycle proteins studied between HR-HPV DNA-positive and negative OSCC affecting young patients.



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