Author response

Dr Weinberger disagrees with my assertion that large studies1–5 demonstrating the safety of combination inhaled glucocorticoid (IGC) and long-acting–agonist (LABA) therapy are compelling because they did not include patients with life-threatening asthma. Dr Weinberger describes a case report he published in 2006 of 2 children with poorly controlled asthma despite high-dose IGC and LABA combination therapy who developed life-threatening episodes of bronchospasm after exercise that were not prevented by albuterol pretreatment.

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