Common variable immune deficiency associated with pemphigoid

Common variable immune deficiency (CVID) is a primary humoral immunodeficiency of adulthood characterized by reduced levels of at least 2 serum immunoglobulins isotypes and impaired antibody response to polysaccharide antigens. These immunologic defects predispose the patient to recurrent respiratory tract infections, such as recurrent sinusitis, otitis media, bronchitis, and pneumonia.1,2

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