Asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL10+ M2-like macrophages around airways compared to healthy airways

Publication date: Available online 19 December 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Christina Draijer, Carian E. Boorsma, Patricia Robbe, Wim Timens, Machteld N. Hylkema, Nick H.T. Ten Hacken, Maarten van den Berge, Dirkje S. Postma, Barbro N. Melgert
In asthma, macrophage polarization is altered from a state associated with anti-inflammatory responses to a state associated with inflammation as compared to control. Macrophage polarization states is linked to disease severity, sex and ICS treatment.



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