Bioactive peptides hidden in human salivary proteins

Publication date: Available online 5 December 2016
Source:Journal of Oral Biosciences
Author(s): Eiichi Saitoh, Masayuki Taniguchi, Akihito Ochiai, Tetsuo Kato, Akane Imai, Satoko Isemura
BackgroundExtensive peptidomic studies of human saliva have resulted in considerable advances in the field of proteomics. As the next generation in salivary research, a comprehensive understanding of the biological functions of in vivo peptides generated by proteolysis in the oral cavity has been long awaited. A cyclopedic functional analysis of salivary peptides may bring promising therapeutic agents and novel clinical applications.ConclusionHuman salivary proteins have the ability to generate bioactive peptides upon proteolytic cleavage.



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