Orofacial antinociceptive activity of (S)-(−)-perillyl alcohol in mice: a randomized, controlled and triple-blind study

This study investigated the antinociceptive effects of (S)-(−)-perillyl alcohol (PA) on orofacial nociception in Swiss male mice using formalin-, capsaicin-, and glutamate-induced pain tests. For each test, eight animals per group were pre-treated intraperitoneally by a blinded investigator with PA (50 or 75mg/kg), morphine, or vehicle (saline+0.2% Tween 80). The treatment was performed before the induction of orofacial nociception by injecting formalin, capsaicin, or glutamate solution into the right area of the upper lip.

http://ift.tt/2lH7Zou