The impact of various scaffold components on vascularized bone constructs

Bone tissue engineering is gaining more interest in the field of craniofacial surgery where continuous efforts are being made to improve the outcomes via modulation of the scaffold components. In an in vitro three dimensional (3D) culture the effect of bone morphogenic protein 2 (BMP2, 60 μg / ml) and the effect of different cell seeding densities (0.25, 0.5, and 1 x 104) of rat mesenchymal stem cells seeded on nanocrystalline hydroxyapatite in silica gel matrix (Nanobone®) on the cell viability and differentiation were studied.

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