Multimodal therapy facilitates a fast-track recovery after surgery - are potential drug-drug interactions of clinical significance in the perioperative period?

Anesthesiologists play an increasingly important role in facilitating a fast-track recovery after surgery [1]. Optimal management of perioperative pain using opioid-sparing multimodal analgesic techniques and preventing postoperative nausea and vomiting (PONV) using prophylactic antiemetics are key elements for achieving an enhanced recovery after surgery [2,3]. Use of multiple non-opioid analgesics acting at differing sites within the central and peripheral nervous systems is a well-documented approach to improving postoperative pain management, with numerous studies demonstrating improvement in pain scores, reduction in opioid usage (opioid-sparing) and adverse side effects, leading to a faster recovery following surgery [4].

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