New concepts of personalized therapy in salivary gland carcinomas

During embryonal development, the primitive oropharynx epithelia form tubules which differentiate to adenoid tissues of salivary glands and lungs. Despite this similar ontogenetic origin, both tissues have different vulnerability to carcinogenic factors and may give rise to different adenoid cancer types. Most lung cancers can be grouped into neuroendocrine/small cell, adenocarcinomas and squamous carcinomas and the major risk factor is smoking. In contrast to lung cancer (smoking) but also in contrast to oral squamous carcinomas (smoking, alcohol, human papilloma virus), salivary gland carcinomas have no such common risk factors [1,2].

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