Why are we still unable to accurately determine the malignant potential or the behavior of oral mucosal lesions?

Despite technological advances in medicine, health care providers struggle with the inability to determine the malignant potential of oral mucosal lesions and consequently, the insufficiency in early diagnosis of oral mucosal malignancies. Due to the relatively rare occurrence of oral malignant disease, differentiating ominous lesions of the oral mucosa from much more common benign lesions is challenging since these lesions may have similar appearances and they may not cause clinical complaints of malignant lesions until reaching an advanced stage [1,2].

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