Clinical approach to the patient with refractory atopic dermatitis

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that affects 20% to 30% of children and 7% to 10% of adults.1,2 Most patients have atopic comorbidities, including food allergy, asthma, and allergic rhinitis. Nearly 50% of children with AD continue to have symptoms into adulthood.1 Adult-onset AD is also increasingly being identified as a distinct subset of AD, and these patients are at risk for systemic complications, including rheumatoid arthritis and inflammatory bowel disease.

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