iKnife Rapid Evaporative Ionisation Mass Spectrometry (REIMS) Technology In Head and Neck Surgery. A Ex Vivo Feasibility Study

Introduction: iKnife technology (Waters Corporation) utilises mass spectrometry to determine chemical composition of biological tissue. The development of Rapid Evaporative Ionisation Mass Spectrometry (REIMS) allows direct analysis of vapour produced from tissue cutting techniques such as diathermy and laser. No sample preparation is required and this real-time analysis has potential use in margin assessment during tumour ablation in head and neck malignancy, as well as potential applications in transoral laser and robotic techniques.

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