The most implausible aspect of cancer therapy is to develop drugs to seize the progression of initial stages of carcinogenesis, preferably termed as known as chemopreventive agents [1]. Though studies support oral premalignancy to be an ideal study model for chemopreventive agents [2], curbing oral cancer by concentrating on dietary chemoprevention agents are yet to be developed with time [3]. The example study being of 13-cis-retinoic acid, which was ratified successful till cessation of therapy reverted the premalignancy, making it a gross disappointment [2].
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