Sequential injection of radioactive nanosized colloids followed by indocyanine green for sentinel lymph node detection in oral squamous cell carcinoma: A proof of concept

Radioactive colloids are routinely employed in sentinel lymph node (SLN) detection procedures [1–5]. Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging has also been successfully used in SLN procedures [6–8]. However, minimal skin incisions were not achievable. Hybrid dyes, combining ICG and radioactive colloids, have also been used in SLN procedures [9,10]. However, the use of a hybrid dye will require market authorization and investment to elaborate the tracer. In head and neck cancers, SLN mapping using sequential injection of a radioactive colloid followed by ICG has not been described yet.

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