Spontaneous brain activity and connectivity in female patients with temporomandibular joint synovitis pain: a pilot functional magnetic resonance imaging study

Publication date: Available online 30 May 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Juan Zhang, Xin Li, Zhen Jin, Meng Liang, Xuchen Ma
Objective.It has been proposed that mechanisms in the central nervous system contribute to the development and maintenance of pain in temporomandibular disorders. Here we tested whether spontaneous brain activity and functional connectivity (FC) were altered in patients with temporomandibular joint (TMJ) synovitis pain.Study design.A prospective, cross-sectional design was adopted. Each of 8 patients and 10 healthy controls (HCs) underwent two sessions of functional magnetic resonance imaging: mouth closed and mouth open (painful for patients). Regional Homogeneity (ReHo) was used to measure spontaneous brain activity in each participant. Brain areas with altered ReHo in patients compared to HCs were identified, and their FCs with the rest of the brain were examined and compared between groups.Results.Compared with the HCs, the patients showed decreased pain-related ReHo in the right anterior insula (rAI). The rAI showed a weaker positive FC with the left mid-cingulate cortex (MCC) and a weaker negative FC with the right precuneus in patients compared with HCs. Furthermore, the rAI-MCC FC showed a negative correlation with pain intensity in patients.Conclusions.These results provide evidence supporting altered pain-related spontaneous brain activity and functional connectivity in the central nervous system in patients with TMJ synovitis pain.



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