The Synergistic Effects of IL-6/IL-17A Promote Osteogenic Differentiation by Improving OPG/RANKL Ratio and Adhesion of MC3T3-E1 Cells on Hydroxyapatite

Osseointegration is the dynamic interaction of living bone with a biocompatible implant in the absence of an interposing soft-tissue layer. At a cellular level, the relationship of an implant with the surrounding tissue is highly dependent on the interaction between the materials and biological elements such as osteoblasts, collagen, fibroblasts, and blood components (Alghamdi et al., 2014). Various techniques and additives have been utilized to improve osseointegration; recent studies have demonstrated that biomolecules such as growth factors, proteins, and cytokines play essential roles in enhancing bone regeneration (Vo et al., 2012).

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