Three-dimensional microarchitecture and local mineralization of human jaws affected by bisphosphonate-related osteonecrosis

Recently, we showed that osteocyte lacunar volume and distribution, as well as mineralized bone mass density, are dependent on the specific region of the jaw in patients suffering from bisphosphonate-related osteonecrosis of the jaw (BRONJ) [1]. Indeed, a significant heterogeneity was found in terms of osteocyte lacunar morphology, most likely due to the variety of mechanical loading in the different regions.

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