A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis

This review provides evidence supporting some efficacy of topical agents and phototherapy in treatment of prurigo nodularis, while highlighting emerging therapeutic potential from modulation of neurokinin-1 receptor, interleukin-31 receptor, and κ-opioid receptor signaling. Higher-powered studies for prurigo nodularis treatments are needed.

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