Comparative effectiveness of treatment of actinic keratosis with topical fluorouracil and imiquimod in the prevention of keratinocyte carcinoma: a cohort study

5-fluorouracil and imiquimod are frequently prescribed actinic keratosis treatments, but no studies have compared their effectiveness at preventing keratinocyte carcinoma in a real-world setting. Whereas 5-fluorouracil was more effective in reducing keratinocyte carcinoma risk overall, we found no differences in the short- or long-term risk of site-specific keratinocyte carcinoma.

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