Medicine,New Articles,November 11th,2015

Does Alcohol Consumption Affect the Risk for Parkinson’s Disease?

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

A systematic review of the relevant literature from 2000-2014, from observational studies, found little evidence for either a positive or negative effect on PD risk from alcohol consumption. When weak associations were observed in some reports, the authors found that the studies were at greater risk of selection and recall bias, which could compromise the effects found. Sixteen articles that met the criteria for inclusion were identified. All were primary research articles, published in English in peer-reviewed journals. These studies had to include a comparison or control group ... περισσότερα »

Gaucher Disease May Protect Against Parkinson’s Disease-Related Color Visual Impairment

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

"Consistent with previous studies, color discrimination was decreased in patients with PD. However, this study introduces new findings that relate to the impact of GD in the context of PD-related color discrimination. These findings may imply a 'protective effect' on color discrimination in those GD patients who also have PD, which probably is due to a sensory mechanism rather than a cognitive effect," explained lead investigator Deborah Elstein, PhD, of the Gaucher Clinic at Shaare Zedek Medical Center Jerusalem (Israel), which is the largest clinic of its kind, devoted solely to... περισσότερα »

Identification of Odorant Binding Proteins and Chemosensory Proteins

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Identification of Odorant Binding Proteins and Chemosensory Proteins in Antennal Transcriptomes of the Jumping Bristletail Lepismachilis y-signata and the Firebrat Thermobia domestica: Evidence for an Independent OBP-OR Origin: Chemosensory protein (CSP) and gustatory receptor genes have been identified in all major arthropod groups. However, odorant binding proteins (OBP) and olfactory receptor genes are insect specific, suggesting that both gene families originated after the Hexapoda*–*Crustacea split (~470 million years ago). The seemingly parallel diversification of OBP and ol... περισσότερα »

A gunshot wound to the face

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Rapid Response and Multidisciplinary Teamwork Save a Young Man’s Life: A gunshot wound to the face – a random act of violence in Beaumont, Texas – forever changed the life of 21-year-old Adair Stephens. The shooting occurred late in the afternoon on a Saturday in September 2013. After being rushed to the emergency center at Baptist Beaumont Hospital, Stephens was transported by Memorial Hermann Life Flight® to the Texas Trauma Institute at Memorial Hermann-Texas Medical Center, where the Level I trauma team stabilized him. He was taken to the OR by ophthalmologist Nan Wang, MD, P... περισσότερα »

With a Bone-anchored Hearing Aid, One Good Ear Helps the Other

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

With a Bone-anchored Hearing Aid, One Good Ear Helps the Other: In early June 2014, Steve Blatt was riding his motorcycle to work along the same route he’d used for nearly 40 years. It was raining, and when his front tire hit an uneven spot in the road, his bike slid out from under him. He did two somersaults through the air and lost his helmet. When he hit the ground, he suffered a transverse fracture through his right temporal bone – the hardest bone in the body – a complex structure that houses the cochlear and vestibular end organs, the facial nerve, the carotid artery and t... περισσότερα »

Human Immunodeficiency Virus-associated primary effusion lymphoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Human Immunodeficiency Virus-associated primary effusion lymphoma: An exceedingly rare entity in cerebrospinal fluid: *Sarika Jain, Alka Palekar, Sara E Monaco, Fiona E Craig, Ghassan Bejjani, Liron Pantanowitz* CytoJournal 2015 12(1):22-22 Primary effusion lymphoma (PEL) in patients with Human Immunodeficiency Virus (HIV) infection may involve pleural, pericardial, and peritoneal cavities. PEL involving the cerebrospinal fluid (CSF) is exceedingly rare, and to our knowledge has only been reported in two cases. We report another case of PEL diagnosed in CSF from a 61-year-old ma... περισσότερα »

Selumetinib in Combination With MEDI4736 in Patients With Advanced Solid Tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Ascending Doses of Selumetinib in Combination With MEDI4736 in Patients With Advanced Solid Tumours: *Conditions*: Lung Cancer; Melanoma; Head and Neck Carcinoma; Gastroesophageal Cancer; Breast Cancer; Pancreatic Adenocarcinoma; Colorectal Cancer *Intervention*: Drug: Selumetinib and Medi4736 *Sponsor*: AstraZeneca *Not yet recruiting* - verified October 2015 ArmsAssigned InterventionsExperimental: Cohort 1 Selumetinib Orally + MEDI4736 IV Drug: Selumetinib and Medi4736 Se... περισσότερα »

Thulium Contact Laser of Laryngotracheal Stenosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Thulium Contact Laser of Laryngotracheal Stenosis: *Conditions*: Laryngeal Carcinoma; Bilateral Vocal Cord Paresis; Subglottic Stenosis *Interventions*: Procedure: laryngeal carcinoma; Procedure: bilateral vocal cord paralysis; Procedure: subglottic stenosis *Sponsor*: University Hospital Ostrava *Recruiting* - verified October 2015 ArmsAssigned InterventionsExperimental: laryngeal carcinoma patients with T1-T2 (some T3) laryngeal carcinoma will undergo treatment using thulium contact laser surgery - tumour resection Procedure: laryngeal carcinoma treatment of laryng... περισσότερα »

Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer: *Condition*: Radiation-Induced Xerostomia *Interventions*: Other: Standard Oral Hygiene; Other: Standard Oral Hygiene + True Acupuncture; Other: Standard Oral Hygiene + Sham Acupuncture *Sponsor*: Wake Forest NCORP Research Base *Not yet recruiting* - verified October 2015 ArmsAssigned InterventionsActive Comparator: Standard Oral Hygiene All patients will receive standard oral hygiene patient teaching information that includes instructions regarding mouth rinses, use of lip balms, use of mi... περισσότερα »

A Phase II Clinical Trial of Chemotherapy With or Without Endostar® Continuous Intravenous Infusion in Refractory NPC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

A Phase II Clinical Trial of Chemotherapy With or Without Endostar® Continuous Intravenous Infusion in Refractory NPC: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Recombinant Human Endostatin Injection (Endostar); Drug: Fluorouracil (5-Fu); Drug: Nedaplatin *Sponsors*: Yun-fei Xia; Jiangsu Simcere Pharmaceutical Co., Ltd. *Recruiting* - verified October 2015 We define refractory nasopharyngeal carcinoma as the following: recurrence with radiation brain injury after radiotherapy, recurrence after the second or more courses of radiotherapy, standard tr... περισσότερα »

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK1/2/3, ROS1, or ALK Gene Rearrangements (Fusions)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK1/2/3, ROS1, or ALK Gene Rearrangements (Fusions): *Conditions*: Breast Cancer; Cholangiocarcinoma; Colorectal Cancer; Head and Neck Neoplasms; Lymphoma, Large-Cell, Anaplastic; Melanoma; Neuroendocrine Tumors; Non-Small Cell Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Papillary Thyroid Cancer; Primary Brain Tumors; Renal Cell Carcinoma; Sarcomas; Salivary Gland Cancers; Adult Solid Tumor *Intervention*: Drug: Entrectinib *Sponsor*: Ignyta, In... περισσότερα »

Cobiprostone for the Prevention of Oral Mucositis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Cobiprostone for the Prevention of Oral Mucositis in Subjects With Head and Neck Cancer: *Condition*: Oral Mucositis *Interventions*: Drug: Cobiprostone; Drug: Placebo *Sponsors*: Sucampo AG; Sucampo Pharma Americas, LLC *Recruiting* - verified October 2015 ArmsAssigned InterventionsExperimental: Cobiprostone 30 mcg four times daily Cobiprostone 30 mcg Drug: Cobiprostone Other Name: SPI-8811 Experimental: Cobiprostone 15 mcg four times daily Cobiprostone 15 mcg Drug: Cobiprostone Other Name: SPI-8811 Placebo Comparator: Placebo 0 mcg four times daily Placebo Drug: Placebo ... περισσότερα »

Trental for the Treatment of Vertigo/Dizziness/Imbalance

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Trental for the Treatment of Vertigo/Dizziness/Imbalance: *Conditions*: Dizziness; Vertigo *Interventions*: Drug: Pentoxifylline; Drug: Placebo *Sponsor*: University of Missouri-Columbia *Recruiting* - verified October 2015 Imbalance, dizziness and vertigo as a result of problems in the inner ear (vestibular dysfunction) are becoming increasingly more prevalent in Americans 40 years of age and older. The symptoms have a severe impact on affected individuals with detrimental effects on work, travel, social and family life. These patients see doctors often with no relief... περισσότερα »

Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and Neck Cancer: *Condition*: Head and Neck Squamous Cell Carcinoma *Intervention*: Drug: ruxolitinib *Sponsor*: University of Pittsburgh *Not yet recruiting* - verified October 2015 ArmsAssigned InterventionsExperimental: ruxolitinib Ruxolitinib will be taken orally for 14-21 days prior to surgery, every morning and every evening, and will be discontinued after the morning dose on the day of planned surgical resection. Drug: ruxolitinib Detailed Description: In this study, ruxolitinib wil... περισσότερα »

A Phase 1 Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

A Phase 1 Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors: *Condition*: Solid Cancers *Intervention*: Drug: MPDL3280A *Sponsor*: Genentech, Inc. *Recruiting* - verified November 2015

Reproducibility of Intratumor Distribution of 18F-EF5 in Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Reproducibility of Intratumor Distribution of 18F-EF5 in Head and Neck Cancer: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: 18F-EF5; Procedure: Pretreatment PET/CT-scan (performed two times) *Sponsor*: Turku University Hospital *Recruiting* - verified November 2015 ArmsAssigned InterventionsExperimental: 18F-EF5 PET/CT scanDrug: 18F-EF5 Procedure: Pretreatment PET/CT-scan (performed two times) Detailed Description: All patients will undergo normal diagnostic and staging procedures, including a conventional 18F-FDG PET/CT scan for the ... περισσότερα »

LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

A Study of LY3127804 With Ramucirumab in Participants With Advanced Solid Tumors: *Conditions*: Solid Tumors; Gastro-esophageal Junction Adenocarcinoma; Hepatocellular Carcinoma *Interventions*: Drug: LY3127804; Drug: Ramucirumab *Sponsor*: Eli Lilly and Company *Not yet recruiting* - verified November 2015 ArmsAssigned InterventionsExperimental: Part A LY3127804 Dose escalation of LY3127804 given intravenously (IV) every 2 weeks (Q2W) for 28 day cycle. Drug: LY3127804 Administered IV Experimental: Part B LY3127804 + Ramucirumab Dose 1 Dose escalation of LY3127804 in c... περισσότερα »

Nasopharyngeal Carcinoma Post IMRT

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Nasopharyngeal Carcinoma Post IMRT: *Condition*: Nasopharyngeal Carcinoma *Intervention*: *Sponsor*: University Health Network, Toronto *Recruiting* - verified November 2015 Groups/CohortsPatient Nasopharyngeal carcinoma (NPC) patients who are disease free more than four years after definitive management with radiotherapy +/- chemotherapy who were treated with Intensity-Modulated Radiotherapy (IMRT), study will involve Collection of demographic data, endocrine assessment (Pituitary and Thyroid), Patient reported outcomes (Quality of Life Questionnaire), neurocognitive ass... περισσότερα »

Retrovirology

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 19 ώρες

*Retrovirology - Latest Articles* - Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys Background: Bone marrow stromal cell antigen 2 (BST2), also known as tetherin, HM1.24 or CD317 represents a type 2 integral membrane protein, which has been described to restrict the production of some enveloped viruses by inhibiting the virus release from the cell surface. This innate antiviral mechanism is counteracted by the HIV-1 viral factor Vpu, targeting BST2 for cellular degradation. Since antiviral BST2 act...περισσότερα »

Virusworld, Jean-Yves Sgro, Institute for Molecular Virology, University of Wisconsin-Madison

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 19 ώρες

*Journal of Virology Structure and Assembly* - Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins [Structure and Assembly] The nairoviruses include assorted tick-borne bunyaviruses that are emerging as causative agents of infectious diseases among humans and animals. As negative-sense single-stranded RNA (nndash;ssRNA) viruses, nairoviruses encode nucleoprotein (NP) that encapsidates the genomic RNA and further forms ribonucleoprotein (RNP) complex with viral RNA-dependent RNA polymerase (RdRp). We previously revealed that the monomeric NP encoded by Crimean-Con... περισσότερα »

Journal of Virology

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 19 ώρες

- Advanced Online Publications Articles Current Issue of Journal of Virology*JVI Current Issue* - Editorial Board [Masthead] - Articles of Significant Interest Selected from This Issue by the Editors [Spotlight] - Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins [Structure and Assembly] The nairoviruses include assorted tick-borne bunyaviruses that are emerging as causative agents of infectious diseases among humans and animals. As negative-sense single-stranded RNA (nndash;ssRNA) viruses, nairoviruses encode nucleoprotein (NP) that encapsidates the genomic R... περισσότερα »

Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer in

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer in: *Condition*: Esophageal Cancer *Interventions*: Drug: TH-302; Other: HX4 scan; Drug: Carboplatin; Drug: Paclitaxel; Radiation: Radiotherapy; Procedure: surgery *Sponsors*: Maastricht Radiation Oncology; Threshold Pharmaceuticals; Atrium Medical Center *Not yet recruiting* - verified November 2015 ArmsAssigned Interventionstreatment treatment arm: TH-302 pre-treatment day 4 and weekly during treatment. 5 x carboplatin and paclitaxel, radiotherapy: 23 x 1.8Gy HX4 scans d... περισσότερα »

Comparing Immobilisation Shells in Cranial Radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Comparing Immobilisation Shells in Cranial Radiotherapy: *Conditions*: Brain Metastases; Primary Central Nervous System Lymphoma; Bone Metastases *Interventions*: Device: Group A: Closed-face shell; Device: Group B: Open-face shell *Sponsor*: Royal Marsden NHS Foundation Trust *Not yet recruiting* - verified November 2015 ArmsAssigned InterventionsActive Comparator: Group A: Closed-face shells Cranial radiotherapy using the control closed-face immobilisation shell. Device: Group A: Closed-face shell As for arm description Experimental: Group B: open-face shell Cranial ... περισσότερα »

Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy: *Condition*: Melanoma *Interventions*: Drug: Ipilimumab; Radiation: Radiation Therapy *Sponsor*: Stanford University *Recruiting* - verified November 2015 ArmsAssigned InterventionsExperimental: Ipilimumab Treatment + Radiation Therapy Ipilimumab (BMS-734016, MDX010, MDX-CTLA4 Drug: Ipilimumab Patient specific, calculated, iv Other Names: - MDX-101 - Yervoy Radiation: Radiation Therapy Standard of care Other Names: - radiotherapy - radiation oncology Detailed Description: T... περισσότερα »

Can nitric oxide induce migraine in normal individuals?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Can nitric oxide induce migraine in normal individuals?: Introduction For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks. Discussion Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in n... περισσότερα »

Meningeal norepinephrine produces headache behaviors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Meningeal norepinephrine produces headache behaviors in rats via actions both on dural afferents and fibroblasts: Background Stress is commonly reported to contribute to migraine although mechanisms by which this may occur are not fully known. The purpose of these studies was to examine whether norepinephrine (NE), the primary sympathetic efferent transmitter, acts on processes in the meninges that may contribute to the pain of migraine. Methods NE was applied to rat dura using a behavioral model of headache. Primary cultures of rat trigeminal ganglia retrogradely labeled from the ...περισσότερα »

Fulminant acephalgic giant cell arteritis with basal cerebral artery occlusion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Fulminant acephalgic giant cell arteritis with basal cerebral artery occlusion: A radiological and clinico-pathological study 1. Suresh Kumar Chhetri1,2 2. Dorothea Bindman2 3. Jacob Joseph3 4. Sachin Mathur4 5. Sandip Shaunak2 1. 1The University of Manchester, Manchester Academic Health Science Centre, UK 2. 2Department of Neurology, Royal Preston Hospital, UK 3. 3Department of Neuropathology, Royal Preston Hospital, UK 4. 4Department of Neuroradiology, Royal Preston Hospital, UK 1. Suresh Kumar Chhetri, Department of Neurology, Royal Preston ... περισσότερα »

Gender aspects of the relationship between migraine and cardiovascular risk factors: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Gender aspects of the relationship between migraine and cardiovascular risk factors: A cross-sectional evaluation in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Background The relationship between cardiovascular risk factors (CVRF) and migraine is controversial and might be different in both genders. These associations were evaluated in Brazilian middle-aged men and women from the Longitudinal Study of Adult Health (ELSA-Brasil). Methods The cross-sectional relationship between our main outcome, which was migraine headache (definite, probable and overall), and C... περισσότερα »

Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Pilot Ipilimumab in Stage IV Melanoma Receiving Palliative Radiation Therapy: *Condition*: Melanoma *Interventions*: Drug: Ipilimumab; Radiation: Radiation Therapy *Sponsor*: Stanford University *Recruiting* - verified November 2015 ArmsAssigned InterventionsExperimental: Ipilimumab Treatment + Radiation Therapy Ipilimumab (BMS-734016, MDX010, MDX-CTLA4 Drug: Ipilimumab Patient specific, calculated, iv Other Names: - MDX-101 - Yervoy Radiation: Radiation Therapy Standard of care Other Names: - radiotherapy - radiation oncology Detailed Description: T... περισσότερα »

Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational Plagiocephaly

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Investigating the Effectiveness of Mobilization on Congenital Muscular Torticollis and Deformational Plagiocephaly: *Condition*: Congenital Muscular Torticollis *Interventions*: Other: soft tissue mobilization; Other: home program controlled once six weeks *Sponsor*: Hacettepe University *Recruiting* - verified November 2015 ArmsAssigned InterventionsExperimental: Soft tissue mobilization group soft tissue mobilization was applied three times in a week and home program exercises were recommended which consisted of positioning theneck and head, handling strategies, stretc...περισσότερα »

Maltodextrin Acceptance and Preference in Eight Mouse Strains

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Maltodextrin Acceptance and Preference in Eight Mouse Strains: Rodents are strongly attracted to the taste(s) of maltodextrins. A first step toward discovery of the underlying genes involves identifying phenotypic differences among inbred strains of mice. To do this, we used 5-s brief-access tests and 48-h 2-bottle choice tests to survey the avidity for the maltodextrin, Maltrin M040, of mice from 8 inbred strains (129S1/SvImJ, A/J, CAST/EiJ, C57BL/6J, NOD/ShiLTJ, NZO/HlLtJ, PWK/PhJ, and WSB/EiJ). In brief-access tests, the CAST and PWK strains licked significantly less maltodextri...περισσότερα »

Enhancement of Odor-Induced Activity in the Canine Brain by Zinc Nanoparticles: A Functional MRI Study in Fully Unrestrained Conscious Dogs

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Enhancement of Odor-Induced Activity in the Canine Brain by Zinc Nanoparticles: A Functional MRI Study in Fully Unrestrained Conscious Dogs: Using noninvasive in vivo functional magnetic resonance imaging (fMRI), we demonstrate that the enhancement of odorant response of olfactory receptor neurons by zinc nanoparticles leads to increase in activity in olfaction-related and higher order areas of the dog brain. To study conscious dogs, we employed behavioral training and optical motion tracking for reducing head motion artifacts. We obtained brain activation maps from dogs in both an...περισσότερα »

Dose-Response Functions for the Olfactory, Nasal Trigeminal, and Ocular Trigeminal Detectability of Airborne Chemicals by Humans

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Dose-Response Functions for the Olfactory, Nasal Trigeminal, and Ocular Trigeminal Detectability of Airborne Chemicals by Humans: We gathered from the literature 47 odor and 37 trigeminal (nasal and ocular) chemesthetic psychometric (i.e., detectability or dose–response) functions from a group of 41 chemicals. Vapors delivered were quantified by analytical methods. All functions were very well fitted by the sigmoid (logistic) equation: *y* = 1 / (1 + e{–(*x*–*C*)/*D*}), where parameter *C* quantifies the detection threshold concentration and parameter *D* the steepness of the funct... περισσότερα »

Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES)

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Prevalence and Risk Factors of Self-Reported Smell and Taste Alterations: Results from the 2011-2012 US National Health and Nutrition Examination Survey (NHANES): Chemosensory problems challenge health through diminished ability to detect warning odors, consume a healthy diet, and maintain quality of life. We examined the prevalence and associated risk factors of self-reported chemosensory alterations in 3603 community-dwelling adults (aged 40+ years), from the nationally representative, US National Health and Nutrition Examination Survey (NHANES) 2011–2012. In this new NHANES com...περισσότερα »

Behavioral Analysis of Bitter Taste Perception in Drosophila Larvae

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Behavioral Analysis of Bitter Taste Perception in Drosophila Larvae: Insect larvae, which recognize food sources through chemosensory cues, are a major source of global agricultural loss. Gustation is an important factor that determines feeding behavior, and the gustatory receptors (Grs) act as molecular receptors that recognize diverse chemicals in gustatory receptor neurons (GRNs). The behavior of *Drosophila* larvae is relatively simpler than the adult fly, and a gustatory receptor-to-neuron map was established in a previous study of the major external larval head sensory organs... περισσότερα »

Comparison of Olfactory Identification Patterns among Parkinson's Disease Patients from Different Countries

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Comparison of Olfactory Identification Patterns among Parkinson's Disease Patients from Different Countries: Olfactory function assessment is an important screening tool and also may differentiate Parkinson’s disease (PD) patients from other parkinsonisms, including nondegenerative ones, such as, normal pressure hydrocephalus, vascular, drug induced, or infectious parkinsonism. Several authors in different countries have reported various sets of odors that best differentiate between these conditions. It is debated if distinctive patterns of "restrictive" or "selective" hyposmia in ... περισσότερα »

Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Changes in Olfactory Sensory Neuron Physiology and Olfactory Perceptual Learning After Odorant Exposure in Adult Mice: The adult olfactory system undergoes experience-dependent plasticity to adapt to the olfactory environment. This plasticity may be accompanied by perceptual changes, including improved olfactory discrimination. Here, we assessed experience-dependent changes in the perception of a homologous aldehyde pair by testing mice in a cross-habituation/dishabituation behavioral paradigm before and after a week-long ester-odorant exposure protocol. In a parallel experiment, w... περισσότερα »

Saccharin Taste Conditions Flavor Preference in Weanling Rats

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Saccharin Taste Conditions Flavor Preference in Weanling Rats: Innate and learned taste/flavor preferences to chemical stimuli in weanling rats are not fully understood. Our previous study showed that weanling rats could establish conditioned flavor preferences when low, but not high, concentrations of sucrose solutions were used as associative rewarding stimuli. Here, we examined whether 3-week-old rats could acquire flavor learning when the rewarding stimulus was saccharin, a non-nutritive artificial sweetener. In the acquisition session, they consumed water with a flavor (cherry... περισσότερα »

A Scent of Anxiety: Olfactory Context Conditioning and its Influence on Social Cues

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

A Scent of Anxiety: Olfactory Context Conditioning and its Influence on Social Cues: Perception and evaluation of objects are highly dependent on surrounding contexts. Threatening contexts enhance processing of faces. Because odors are assumed to deliver strong contextual information, the present study aimed at demonstrating 1) that odors can constitute threat and safety contexts, and 2) consequently modulate the processing of faces presented in these contexts. Therefore, previously neutral odors were used as contextual stimuli in a context conditioning paradigm, resulting in an ol...περισσότερα »

Longitudinal Changes in Familiarity, Free and Cued Odor Identification, and Edibility Judgments for Odors in Aging Individuals

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 19 ώρες

Longitudinal Changes in Familiarity, Free and Cued Odor Identification, and Edibility Judgments for Odors in Aging Individuals: This longitudinal study investigated changes in olfaction as assessed by a set of tasks requiring different aspects of semantic information in normal aging individuals. Using 16 odorous items from a standardized olfactory test, the Scandinavian Odor Identification Test, 107 middle aged and older adults were assessed up to three times over a period of 6.5 years, requesting them to rate familiarity and edibility for each odorous item before identifying it wi... περισσότερα »

Submandibular Lateral Ectopic Thyroid Tissue: Ultrasonography, Computed Tomography, and Scintigraphic Findings

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 19 ώρες

Submandibular Lateral Ectopic Thyroid Tissue: Ultrasonography, Computed Tomography, and Scintigraphic Findings: Ectopic thyroid can be encountered anywhere between the base of tongue and pretracheal region. The most common form is euthyroid neck mass. Herein, we aimed to present the findings of a female case with ectopic thyroid tissue localized in the left submandibular region. A 44-year-old female patient, who underwent bilateral subtotal thyroidectomy four years ago with the diagnosis of multinodular goiter, was admitted to our hospital due to a mass localized in the left submandi...περισσότερα »

Increased Mesenchymal Stem Cell Response and Decreased Staphylococcus aureus Adhesion on Titania Nanotubes without Pharmaceuticals

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Titanium (Ti) implants with enhanced biocompatibility and antibacterial property are highly desirable and characterized by improved success rates. In this study, titania nanotubes (TNTs) with various tube diameters were fabricated on Ti surfaces through electrochemical anodization at 10, 30, and 60 V (denoted as NT10, NT30, and NT60, resp.). Ti was also investigated and used as a control. NT10 with a diameter of 30 nm could promote the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) without noticeable differentiation. NT30 with a diameter of 100 nm could s...περισσότερα »

Sustainability, Vol. 7, Pages 14964-14981: A Method to Evaluate the Stimulation of a Real World Field of View by Means of a Spectroradiometric Analysis

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Stimulation elicited by a real world field of view is related to the color, the intensity and the direction of the information reaching the eye: different spectral power distributions of light trigger different responses. An evaluation of the stimulation provided by the field of view can be performed by measuring the spectral radiance with a spectroradiometer and weighting this data with an efficiency curve. Different weights (physical, physiological and psychological) can lead to different analyses and consequently to different results. The proposed method allows an overall and s... περισσότερα »

Nutrients, Vol. 7, Pages 9218-9228: Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L...περισσότερα »

Infratrochlear neuralgia : The infratrochlear nerve supplies the medial aspect of the upper eyelid, the superolateral aspect of the nose and the lacrimal caruncle

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Infratrochlear neuralgia: Introduction The infratrochlear nerve supplies the medial aspect of the upper eyelid, the superolateral aspect of the nose and the lacrimal caruncle. This nerve may contribute to the pain stemming from the trochlea, but infratrochlear neuralgia has not been identified as a specific cause of pain. Methods Over a 10-year period we have been recruiting patients with pain in the internal angle of the orbit that did not show features of trochlear pain. Results Seven patients (six female, one male; mean age, 46.1 ± 18.9) presented with pain in the territory of ... περισσότερα »

Sensitization of the trigeminovascular system following environmental irritant exposure

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Sensitization of the trigeminovascular system following environmental irritant exposure: Background Air pollution is linked to increased emergency room visits for headache, and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that nasal administration of environmental irritants acutely increases meningeal blood flow via a TRPA1-dependent mechanism involving the trigeminovascular system. Here, we examine whether chronic environmental irritant exposure sensi... περισσότερα »

Orthostatic headache from supratentorial meningioma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Orthostatic headache from supratentorial meningioma [image: extract-image]

Triptans use and overuse

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Triptans use and overuse: A pharmacoepidemiology study from the French health insurance system database covering 4.1 million people: Introduction The objective of this study was to estimate and to characterize the actual patterns of triptan use and overuse in France using a drug reimbursement database. Methods We included all people covered by the French General Health Insurance System (GHIS) from the Provence-Alpes-Côte-d’Azur (PACA) and Corsica administrative areas who had at least one dispensed dose of triptans between May 2010 and December 2011. All dispensed doses of triptans,...περισσότερα »

Migraine affects white-matter tract integrity: A diffusion-tensor imaging study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Migraine affects white-matter tract integrity: A diffusion-tensor imaging study: Background Specific white-matter tract alterations in migraine remain to be elucidated. Using diffusion tensor imaging (DTI), this study investigated whether the integrity of white-matter tracts that underlie regions of the "pain matrix" is altered in migraine and interrogated whether the number of years lived with migraine modifies fibertract structure. Methods Global probabilistic tractography was used to assess the anterior thalamic radiations, the corticospinal tracts and the inferior longitudinal ... περισσότερα »

Oligoclonal bands and increased cytokine levels in idiopathic intracranial hypertension

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Oligoclonal bands and increased cytokine levels in idiopathic intracranial hypertension: Objectives The pathogenesis of idiopathic intracranial hypertension (IIH) is currently unknown and there are speculations about the contribution of some immunologic factors. The aim of this study is to investigate the presence of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) and/or serum cytokine levels in patients with IIH. Methods Patients fulfilling revised diagnostic criteria for IIH were included. Their demographic, clinical, ophthalmologic and laboratory features were examined. ... περισσότερα »

Treatment of hemicrania continua with radiofrequency ablation and long-term follow-up

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Treatment of hemicrania continua with radiofrequency ablation and long-term follow-up: Objective The objective of this research is to describe novel procedural treatments for hemicrania continua that allow patients to remain off indomethacin. Methods Case reports are presented. Results We describe four distinct patients with indomethacin-responsive hemicrania continua who were unable to discontinue the use of indomethacin without headache recurrence. No other medications were effective for their syndrome. Secondary causes of headache were ruled out in each case. Each patient unde... περισσότερα »

Headache neuroimaging

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Headache neuroimaging: Routine testing when guidelines recommend against them: Aims The aim of this article is to determine the patient-level factors associated with headache neuroimaging in outpatient practice. Methods Using data from the 2007–2010 National Ambulatory Medical Care Surveys (NAMCS), we estimated headache neuroimaging utilization (cross-sectional). Multivariable logistic regression was used to explore associations between patient-level factors and neuroimaging utilization. A Markov model with Monte Carlo simulation was used to estimate neuroimaging utilization over ...περισσότερα »

Christiaan Huygens (1629–1695) : Huygens' headache

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Huygens' headache: Background Christiaan Huygens (1629–1695) was a Dutch mathematician, physicist, and astronomer. He became well-known as inventor of the pendulum clock and described light as a wave phenomenon. He became Fellow of the Royal Society (London) and member of the Académie des Sciences (Paris). From the correspondence with family members and famous scientists, we learn that he suffered from frequent headaches. Aim To study Huygens' 22-volume *Oeuvres Complètes* (1888–1950) to find letters in which his headaches are mentioned and translate pertinent sections into Englis... περισσότερα »

Severe acute respiratory syndrome (SARS)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

- Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference [Virus-Cell Interactions] Severe acute respiratory syndrome (SARS) emerged in November 2002 as a case of atypical pneumonia in China, and the causative agent of SARS was identified to be a novel coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV). Bone marrow stromal antigen 2 (BST-2; also known as CD317 or tetherin) was initially identified to be a pre-B-cell growth promoter, but it also inhibits the...περισσότερα »

Vesicular stomatitis virus (VSV)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

- Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly [Structure and Assembly] Vesicular stomatitis virus (VSV) assembly requires condensation of the viral ribonucleoprotein (RNP) core with the matrix protein (M) during budding from the plasma membrane. The RNP core comprises the negative-sense genomic RNA completely coated by the nucleocapsid protein (N) and associated by a phosphoprotein (P) with the large polymerase protein (L). To study the assembly of single viral particles, we tagged M and P wit... περισσότερα »

Virology Highlights

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Learn how Poliovirus makes efficient use of its limited coding capacity by using multifunctional precursor proteins Read the full article on ScienceDirect Viral precursor protein P3 and its processed products perform discrete and essential functions in the PV RNA replication complex Poliovirus (PV) is one of the best characterized RNA viruses known, yet a host of questions remain regarding the molecular mechanisms that drive viral replication. In the search for new… The unseen winding road to West Nile virus emergence in California Read the full article on ScienceDirect Genotype-specif...περισσότερα »

Dysphonia after Bevacizumab Rechallenge

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Dysphonia after Bevacizumab Rechallenge: A Case Report: Inhibition of vascular endothelial growth factor (VEGF) signaling, an initiator of tumor angiogenesis, inhibits tumor growth and invasion. Bevacizumab, a monoclonal antibody to VEGF, in common use as an adjunct to standard chemotherapy like irinotecan in advanced colorectal cancer, also affects the normal (nontumor) vasculature. Dysphonia or voice changes have been anecdotally reported in patients that have been exposed to antiangiogenics. In this case report, we present an occurrence of severe dysphonia in a 60-year-old male w... περισσότερα »

Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 19 ώρες

Publication date: Available online 10 November 2015 *Source:*Journal of Genetics and Genomics Author(s): Fangfang Jiang, Falong Lu, Peixue Li, Wei Liu, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang, Yong Q. Zhang Fragile X syndrome (FraX), the most common form of inherited mental retardation, is caused by the absence of the evolutionally conserved fragile X mental retardation protein (FMRP). While neuronal functions of FMRP have been intensively studied for the last two decades, its role in non-neuronal cells remains poorly understood. Piwi, a key component of the Piwi-interacting RNA... περισσότερα »

Langerhans Cell Histiocytosis of the Clavicle in an Adult

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Langerhans Cell Histiocytosis of the Clavicle in an Adult: A Case Report and Review of the Literature: Langerhans cell histiocytosis (LCH) usually occurs in children under the age of 10 years with a predilection for the skull, spine, rib and humerus. Solitary LCH occurring in an adult clavicle is uncommon with limited reports to date. The lesion in our patient was curetted with the intent to make a diagnosis, which subsequently lead to the remission of the symptom and the disease. At the final follow-up after 1 year, no local recurrence or metastasis is observed. Case Rep Oncol 2015... περισσότερα »

Foot Hand Mouth Disease Virus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Botox-Injektion i.d. oberen Sphinkter,Pemphigus des Ösophagus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

http://endoskopiebilder.de/oesophagus_videos.html

Five Simultaneous Primary Tumors in a Single Patient : malignant melanoma of the right popliteal fossa, invasive lobular breast carcinoma, diffuse large B cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and a giant cell tumor of tendon sheath/pigmented villonodular synovitis.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature: Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with 5 distinct tumors within 4 months*: malignant melanoma of the right popliteal fossa, invasive ...περισσότερα »

Primary Diffuse Large B-Cell Lymphoma of the Mandible

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Primary Diffuse Large B-Cell Lymphoma of the Mandible: Case Report and Review of the Literature: In the oral cavity, extranodal non-Hodgkin's lymphoma can occur in the periapical region either in the maxilla or mandible. Also, it can mimic inflammatory lesions that arise around the teeth apices such as periapical granuloma, radicular cyst and osteomyelitis. Misdiagnosis of lymphomas in the jaws may reduce the chance of successful treatment and worsen the prognosis. Therefore, any growth of periapical tissue must be submitted for histopathological evaluation to avoid a delay in the d...περισσότερα »

Central Venous Catheter Insertion for Intensive Chemotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Persistent Left Superior Vena Cava in Hematological Malignancy Requiring Central Venous Catheter Insertion for Intensive Chemotherapy: Persistent left superior vena cava is a congenital vascular anomaly, which is possibly arrhythmogenic and thrombogenic, rarely complicated with coronary sinus atresia. We treated a 42-year-old male with Hodgkin's lymphoma requiring central venous catheter placement for intensive chemotherapy. Persistent left superior vena cava was revealed after the insertion of the central venous catheter by the radiological finding of the catheter tip cannulated in... περισσότερα »

Vibrio alginolyticus Associated Chronic Myringitis Acquired in Mediterranean Waters

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Vibrio alginolyticus Associated Chronic Myringitis Acquired in Mediterranean Waters of Turkey: Vibrio alginolyticus was originally classified as biotype 2 of Vibrio parahaemolyticus. Most clinical isolates are recovered from superficial wounds or the external ear infections. V. alginolyticus is acknowledged to be nearly nonpathogenic in humans. The reason for presence of V. alginolyticus’s virulence is uncertain. We describe a chronic myringitis case in a 47-year-old female due to V. alginolyticus. According to her anamnesis, it was detected that she had sea bathing history in Mugla... περισσότερα »

Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media: Background: The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM). Methods: We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains). Result... περισσότερα »

Discriminant validity and test re-test reproducibility of a gait assessment in patients with vestibular dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Discriminant validity and test re-test reproducibility of a gait assessment in patients with vestibular dysfunction: Background: Gait function may be impaired in patients with vestibular disorders, making gait assessment in the clinical setting relevant for this patient population. The purpose of this study was to evaluate the discriminant validity of a gait assessment protocol between patients with vestibular disorders and healthy participants. Furthermore, test re-test reproducibility and the measurement error of gait performance measures in patients with vestibular lesions was per... περισσότερα »

Outcomes of Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis in Children: Associations With Age and Time Since Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Outcomes of Laryngeal Reinnervation for Unilateral Vocal Fold Paralysis in Children: Associations With Age and Time Since Injury: Objective: Outcomes of laryngeal reinnervation with ansa-cervicalis for unilateral vocal fold paralysis (UVFP) may be influenced by age of the patient and time interval between laryngeal nerve injury and reinnervation, suggesting less favorable outcomes in older patients and greater than 2-year time interval after injury. This study examines these issues in the pediatric population. Method: Review of prospectively collected data set of 35 children and ad... περισσότερα »

Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women [Nutritional epidemiology and public health]: *Background:* Higher intake of certain vitamins may protect against cochlear damage from vascular compromise and oxidative stress, thereby reducing risk of acquired hearing loss, but data are limited. *Objective:* We prospectively examined the relation between carotenoids, vitamin A, vitamin C, vitamin E, and folate intake and risk of self-reported hearing loss in women. *Design:* This prospective cohort study followed 65,521 women ... περισσότερα »

Radioembolization is a cancer treatment in which radioactive particles are delivered to a tumor through the bloodstream

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Radioembolization is a cancer treatment in which radioactive particles are delivered to a tumor through the bloodstream. The particles lodge in the tumor and emit radiation that kills cancer cells. Radioembolization is most often used on cancers in the liver. Radioembolization is sometimes used for patients who may not be able to undergo other treatments. Experts are still determining its ideal uses. What Is Radioembolization? Radioembolization is performed during a procedure called anangiogram. A doctor first inserts a catheter into an artery in the groin. Under X-ray guidance, the ... περισσότερα »

Impact of dual-energy CT prior to radioembolization (RE)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Impact of dual-energy CT prior to radioembolization (RE): Background Depiction of the exact arterial liver anatomy as well as identifying potential extrahepatic non-target vessels is crucial for a successful preparation of radioembolization (RE). Purpose To compare the diagnostic impact of dual-energy computed tomography (DECT) to digital subtraction angiography prior to RE. Material and Methods DECT was applied in 46 patients with hepatocellular carcinoma (HCC) prior to RE. Eighty kV DE as well as reconstructed 120 kV equivalent DE datasets were evaluated in comparison to correla... περισσότερα »

Volumetric glioma quantification: comparison of manual and semi-automatic tumor segmentation for the quantification of tumor growth

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Volumetric glioma quantification: comparison of manual and semi-automatic tumor segmentation for the quantification of tumor growth: Background Volumetric magnetic resonance imaging (MRI) is now widely available and routinely used in the evaluation of high-grade gliomas (HGGs). Ideally, volumetric measurements should be included in this evaluation. However, manual tumor segmentation is time-consuming and suffers from inter-observer variability. Thus, tools for semi-automatic tumor segmentation are needed. Purpose To present a semi-automatic method (SAM) for segmentation of HGGs and ...περισσότερα »

Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Post-PET ultrasound improves specificity of 18F-FDG-PET for recurrent differentiated thyroid cancer while maintaining sensitivity: Background Positron emission tomography (PET) using fluor-18-deoxyglucose (18F-FDG) with or without computed tomography (CT) is generally accepted as the most sensitive imaging modality for diagnosing recurrent differentiated thyroid cancer (DTC) in patients with negative whole body scintigraphy with iodine-131 (I-131). Purpose To assess the potential incremental value of ultrasound (US) over 18F-FDG-PET-CT. Material and Methods Fifty-one consecutive ... περισσότερα »

CT characteristics of dehiscent sigmoid plates presenting as pulsatile tinnitus: a study of 23 patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

CT characteristics of dehiscent sigmoid plates presenting as pulsatile tinnitus: a study of 23 patients: Background Although some features of dehiscent sigmoid plates as a cause of pulsatile tinnitus (PT) have been reported, detailed imaging findings have not been evaluated. Purpose To retrospectively evaluate the computed tomography (CT) features of dehiscent sigmoid plates associated with PT. Material and Methods The CT images of 23 PT patients were assessed to evaluate the features of the dehiscent sigmoid plates, lateral sinuses, and temporal bone pneumatization. Results A ... περισσότερα »

Odontogenic sinusitis accounts for 10-12% of maxillary sinusitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 ώρες

Sinusitis odontogénica, fístula oroantral y su reparación quirúrgica mediante colgajo de bolsa de Bichat: revisión de la literatura via Acta Otorrinolaringológica Española *Source:*Acta Otorrinolaringológica Española Author(s): Gustavo Bravo Cordero, Simona Minzer Ferrer, Lara Fernández La sinusitis odontógena da cuenta del 10 a 12% de los casos de sinusitis maxilar y ocurre por una interrupción del mucoperiostio en respuesta a varias condiciones, siendo la más frecuente la extracción de una pieza dentaria superior. Su manejo consta de dos pilares; tratar la inflamación e infección s...περισσότερα »

Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 19 ώρες

*Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.* Acta Otolaryngol. 2015 Nov 7;:1-5 Authors: Omichi R, Maeda Y, Sugaya A, Kataoka Y, Kariya S, Nagayasu R, Nakagawa A, Yamashita T, Abe K, Nishizaki K Abstract CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance...περισσότερα »

Improved method of gastrostomy tube replacement using a small-caliber transnasal endoscope.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 19 ώρες

*Improved method of gastrostomy tube replacement using a small-caliber transnasal endoscope.* Acta Otolaryngol. 2015 Nov 7;:1-4 Authors: Chang H, Huang Y, Yao W, Zhang L, Li Y Abstract CONCLUSION: Gastrostomy tube replacement using a new approach through the abdominal-wall stoma with a small-caliber trans-nasal endoscope is feasible, fast, and safe compared with the trans-oral approach. OBJECTIVES: To evaluate the feasibility of a new technique using a trans-nasal endoscope for gastrostomy tube replacement. METHODS: Between June 2005 and December 2013 in the Peking University Thir... περισσότερα »

Prognostic value of psychological state in cochlear implantation.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 19 ώρες

*Prognostic value of psychological state in cochlear implantation.* Acta Otolaryngol. 2015 Nov 7;:1-5 Authors: Han JJ, Shin MS, Song JJ, Pai I, Oh S, Kim B, Park JH, Lee JH, Oh SH Abstract CONCLUSION: Perioperative Minnesota Multiphasic Personality Inventory (MMPI) scores may be beneficial for predicting prognosis of cochlear implantation (CI). A positive attitude for social interaction in particular correlates with a better speech outcome. Proper perioperative psychological management may, therefore, assist in the auditory rehabilitation of CI patients. OBJECTIVE: To determine ... περισσότερα »

Severe paraneoplastic hypoglycemia secondary to a gastrointestinal stromal tumour masquerading as a stroke

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 ώρες

Severe paraneoplastic hypoglycemia secondary to a gastrointestinal stromal tumour masquerading as a stroke by G K Dimitriadis via 'Endocrine-related cancer' - EDM Case Reports Search SummaryWe report the case of a 70-year-old previously healthy female who presented acutely to the Accident and Emergency department with left-sided vasomotor symptoms including reduced muscle tone, weakness upon walking and slurred speech. Physical examination confirmed hemiparesis with VIIth nerve palsy and profound hepatomegaly. A random glucose was low at 1.7 mmol/l, which upon correction resolved her ... περισσότερα »

Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 20 ώρες

The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) disease. It is now understood that LTBI and active TB represent a continuous spectrum of states with different degrees of pathogen "activity," host pathology, and immune reactivity. Therefore, it is important to differentiate LTBI and active TB and identify active TB stages. CD4+ T cells play critical role during Mtb infection by mediating protection, contributing to inflammation, and regulating immune response....περισσότερα »

Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Comparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure.* J Laryngol Otol. 2015 Nov 9;:1-8 Authors: Wooles N, Mulheran M, Bray P, Brewster M, Banerjee AR Abstract OBJECTIVE: To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupational noise exposure related auditory deficit. METHODS: A retrospective review was conducted of pure tone audiometry and distortion product otoacoustic emission data obt... περισσότερα »

A novel technique for identifying the fistulous point in a direct carotid-cavernous fistula.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*A novel technique for identifying the fistulous point in a direct carotid-cavernous fistula.* J Clin Neurosci. 2015 Nov 5; Authors: Tsuji K, Nakagawa N, Fukawa N, Nagatsuka K, Nakano N, Kato A Abstract The fistulous point in a direct carotid-cavernous fistula (CCF) can often be difficult to identify because of high-flow shunting. A novel technique that is useful for identifying the fistulous point is reported. A 71-year-old woman underwent endovascular therapy for a left direct CCF that presented with sudden diplopia and tinnitus. To identify the fistulous point, vertebral angi... περισσότερα »

Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

*Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.* PLoS One. 2015;10(11):e0141494 Authors: Lin C, Fesi BD, Marquis M, Bosak NP, Theodorides ML, Avigdor M, McDaniel AH, Duke FF, Lysenko A, Khoshnevisan A, Gantick BR, Arayata CJ, Nelson TM, Bachmanov AA, Reed DR Abstract Genetic variation contributes to individual differences in obesity, but defining the exact relationships between naturally occurring genotypes and their effects on fatness remains elusive. As a step toward positional cloning of previously identified body compos...περισσότερα »

Electrogustometry and contact endoscopy findings in patients with head and neck malignancies treated with chemotherapy, radiotherapy, or radiochemotherapy.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Electrogustometry and contact endoscopy findings in patients with head and neck malignancies treated with chemotherapy, radiotherapy, or radiochemotherapy.* Chem Senses. 2015 Mar;40(3):165-71 Authors: Pavlidis P, Gouveris H, Gorgulla H, Hast HJ, Maurer J Abstract This study aimed to investigate in parallel changes in gustatory function, changes in morphology of the fungiform papillae, as well as changes in the shape and density of the vessels of the tip of the tongue in patients treated with chemotherapy, radioth... περισσότερα »

Loss of olfactory function and nutritional status in vital older adults and geriatric patients.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Loss of olfactory function and nutritional status in vital older adults and geriatric patients.* Chem Senses. 2015 Mar;40(3):197-203 Authors: Toussaint N, de Roon M, van Campen JP, Kremer S, Boesveldt S Abstract The aim of this cross-sectional study was to assess the association of olfactory function and nutritional status in vital older adults and geriatric patients. Three hundred forty-five vital (mean age 67.1 years) and 138 geriatric older adults (mean age 80.9 years) were included. Nutritional status was ass... περισσότερα »

Evidence for different patterns of chemosensory alterations in the elderly population: impact of age versus dependency.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Evidence for different patterns of chemosensory alterations in the elderly population: impact of age versus dependency.* Chem Senses. 2015 Mar;40(3):153-64 Authors: Sulmont-Rossé C, Maître I, Amand M, Symoneaux R, Van Wymelbeke V, Caumon E, Tavarès J, Issanchou S Abstract The present experiment aimed to explore the interindividual variability in chemosensory abilities among the elderly population. The chemosensory abilities of 559 subjects, aged from 65 to 99 years, were evaluated. Various categories of the elder...περισσότερα »

A new gustometer for taste testing in rodents.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *A new gustometer for taste testing in rodents.* Chem Senses. 2015 Mar;40(3):187-96 Authors: Spector AC, Blonde GD, Henderson RP, Treesukosol Y, Hendrick P, Newsome R, Fletcher FH, Tang T, Donaldson JA Abstract In recent years, to circumvent the interpretive limitations associated with intake tests commonly used to assess taste function in rodents, investigators have developed devices called gustometers to deliver small volumes of taste samples and measure immediate responses, thereby increasing confidence that th... περισσότερα »

Advantame sweetener preference in C57BL/6J mice and Sprague-Dawley rats.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Advantame sweetener preference in C57BL/6J mice and Sprague-Dawley rats.* Chem Senses. 2015 Mar;40(3):181-6 Authors: Sclafani A, Ackroff K Abstract Advantame is a new ultrahigh-intensity noncaloric sweetener derived from aspartame and approved for human use. Rats and mice are not attracted to the taste of aspartame and this study determined their preference for advantame. In 24-h choice tests with water, C57BL/6J mice and Sprague-Dawley rats were indifferent to advantame at concentrations of 0.01, 0.03, and 0.1mM...περισσότερα »

Test-retest reliability and validity of the Sniffin' TOM odor memory test.

Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Test-retest reliability and validity of the Sniffin' TOM odor memory test.* Chem Senses. 2015 Mar;40(3):173-9 Authors: Croy I, Zehner C, Larsson M, Zucco GM, Hummel T Abstract Few attempts have been made to develop an olfactory test that captures episodic retention of olfactory information. Assessment of episodic odor memory is of particular interest in aging and in the cognitively impaired as both episodic memory deficits and olfactory loss have been targeted as reliable hallmarks of cognitive decline and impendi... περισσότερα »

Potential of agricultural fungicides for antifungal drug discovery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Potential of agricultural fungicides for antifungal drug discovery.* Expert Opin Drug Discov. 2015 Nov 7;:1-9 Authors: Jampilek J Abstract While it is true that only a small fraction of fungal species are responsible for human mycoses, the increasing prevalence of fungal diseases has highlighted an urgent need to develop new antifungal drugs, especially for systemic administration. This contribution focuses on the similarities between agricultural fungicides and drugs. Inorganic, organometallic and organic compounds can be found amongst agricultural fungicides. Furthermore, fun... περισσότερα »

Targeting intrinsically disordered proteins in rational drug discovery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Targeting intrinsically disordered proteins in rational drug discovery.* Expert Opin Drug Discov. 2015 Nov 7;:1-13 Authors: Ambadipudi S, Zweckstetter M Abstract INTRODUCTION: Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) have gained wide recognition over the past decade due to their versatile roles in cell physiology and pathology. A large repertoire of IDPs/IDPRs has been implicated in numerous diseases, making them potential targets for therapeutic intervention. Recent advances in experimental methods and computational approache... περισσότερα »

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism.* Biochem Soc Trans. 2015 Aug 1;43(4):639-644 Authors: Chartoumpekis DV, Wakabayashi N, Kensler TW Abstract Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor 2-like 2 (Nrf2) pathway is usually activated in cancers and has been suggested to promote cancer cell survival mainly by inducing a large battery of cytoprotective genes. This mini review focuses on metabolic pathways, beyond cytoprotection...περισσότερα »

Reprint of "Characterisation and modelling of the thermorheological properties of pharmaceutical polymers and their blends using capillary rheometry: Implications for hot melt processing of dosage forms".

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Reprint of "Characterisation and modelling of the thermorheological properties of pharmaceutical polymers and their blends using capillary rheometry: Implications for hot melt processing of dosage forms".* Int J Pharm. 2015 Nov 6; Authors: Jones DS, Margetson DN, McAllister MS, Andrews GP Abstract Given the growing interest in thermal processing methods, this study describes the use of an advanced rheological technique, capillary rheometry, to accurately determine the thermorheological properties of two pharmaceutical polymers, Eudragit E100 (E100) and hydroxypropylcellulose JF ...περισσότερα »

Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Plasma biomarker for detection of early stage pancreatic cancer and risk factors for pancreatic malignancy using antibodies for apolipoprotein-AII isoforms.* Sci Rep. 2015;5:15921 Authors: Honda K, Kobayashi M, Okusaka T, Rinaudo JA, Huang Y, Marsh T, Sanada M, Sasajima Y, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Miura N, Kamita M, Sakamoto T, Shoji H, Jung G, Srivastava S, Yamada T Abstract We recently reported that circulating apolipoprotein AII (apoAII) isoforms apoAII-ATQ/AT (C-terminal truncations of the apoAII homo-dimer) decline ...περισσότερα »

Cancer treatment in determination of hearing loss.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Cancer treatment in determination of hearing loss.* Braz J Otorhinolaryngol. 2015 Oct 17; Authors: Oliveira PF, Oliveira CS, Andrade JS, do Carmo Santos TF, de Oliveira-Barreto AC Abstract INTRODUCTION: Chemotherapy and radiotherapy in oncology have repercussions in hearing health, and can damage structures of the inner ear. These repercussions usually, result in a bilateral and irreversible hearing loss. OBJECTIVE: To identify sensorineural hearing loss cases with complaints of tinnitus and difficulty in speech understanding and investigate their relationship with the types of ... περισσότερα »

Morphine-Induced MOR-1X and ASF/SF2 Expression Is Independent of Transcriptional Regulation: Implications for MOR-1X Signaling

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 20 ώρες

ABSTRACT Recently, multiple μ-opioid receptor (MOR) isoforms have been identified that originate from a single gene, OPRM1; however, both their regulation and their functional significance are poorly characterized. The objectives of this study were to decipher, first, the regulation of alternatively spliced μ-opioid receptor isoforms and the spliceosome components that determine splicing specificity and, second, the signaling pathways utilized by particular isoforms both constitutively and following agonist binding. Our studies demonstrated that the expression of a particular splic... περισσότερα »

Carbonic anhydrase 9 mRNA/microRNA34a interplay in hypoxic human mammospheres

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 20 ώρες

Abstract The hypoxic environment is a crucial component of the cancer stem cell niche and it is capable of eliciting stem cell features in cancer cells. We previously reported that *SNAI2* up-regulates the expression of Carbonic Anhydrase iso-enzyme 9 (*CA9*) in hypoxic MCF7 cells. Here we show that *SNAI2* down-regulates *miR34a* expression in hypoxic MCF7 cell-derived mammospheres. Next, we report on the capability of *miR34a* to decrease *CA9* mRNA stability and CA9 protein expression. We also convey that the over-expression of cloned *CA9*-mRNA-3'UTR increases the mRNA half-lif... περισσότερα »

Contemporary approaches to basal cell carcinoma diagnosis and treatment

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 20 ώρες

Future Oncology November 2015, Vol. 11, No. 22, Pages 2965-2966. from Cancer via ola Kala on Inoreader http://ift.tt/1linHCO via IFTTT

Contemporary approaches to basal cell carcinoma diagnosis and treatment

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 20 ώρες

Future Oncology November 2015, Vol. 11, No. 22, Pages 2965-2966. from Cancer via ola Kala on Inoreader http://ift.tt/1linHCO via IFTTT

Measurement of Voluntary Cough Production and Airway Protection in Parkinson Disease.

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

*Measurement of Voluntary Cough Production and Airway Protection in Parkinson Disease.* Arch Phys Med Rehabil. 2015 Nov 6; Authors: Silverman EP, Carnaby-Mann G, Singletary F, Hoffman-Ruddy B, Yeager J, Sapienza C Abstract OBJECTIVE: To examine relationships between Peak expiratory (cough) airflow rate and swallowing symptom severity in participants with Parkinson Disease DESIGN: Participants were cued to cough into an analog peak flow meter then swallowed three, 20 mL thin liquid barium boluses. Analyses were directed at detecting potential relationships among disease severity,... περισσότερα »

Tongue acupuncture in treatment of post-stroke dysphagia.

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

*Tongue acupuncture in treatment of post-stroke dysphagia.* Int J Clin Exp Med. 2015;8(8):14090-4 Authors: Cai H, Ma B, Gao X, Gao H Abstract Tongue acupuncture is a technique that treats illness through acupuncture applied to the tongue. This study was designed to assess its therapeutic effects in the treatment of post-stroke dysphagia. A clinical control study was conducted with randomly selected 180 patients with post-stroke dysphagia. The patients were assigned into 2 groups: 90 in the Tongue acupuncture group received tongue acupuncture on the basis of conventional medicati... περισσότερα »

Cancer treatment in determination of hearing loss.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Cancer treatment in determination of hearing loss.* Braz J Otorhinolaryngol. 2015 Oct 17; Authors: Oliveira PF, Oliveira CS, Andrade JS, do Carmo Santos TF, de Oliveira-Barreto AC Abstract INTRODUCTION: Chemotherapy and radiotherapy in oncology have repercussions in hearing health, and can damage structures of the inner ear. These repercussions usually, result in a bilateral and irreversible hearing loss. OBJECTIVE: To identify sensorineural hearing loss cases with complaints of tinnitus and difficulty in speech understanding and investigate their relationship with the types of ... περισσότερα »

High doses of salicylate reduces glycinergic inhibition in the dorsal cochlear nucleus of the rat.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*High doses of salicylate reduces glycinergic inhibition in the dorsal cochlear nucleus of the rat.* Hear Res. 2015 Nov 5; Authors: Zugaib J, Ceballos CC, Leão RM Abstract High doses of salicylate induce reversible tinnitus in experimental animals and humans, and is a common tinnitus model. Salicylate probably acts centrally and induces hyperactivity in specific auditory brainstem areas like the dorsal cochlear nucleus (DCN). However, little is known about the effect of high doses of salicylate in synapses and neurons of the DCN. Here we investigated the effects of salicylate on... περισσότερα »

Anterior petrosal approach: The safety of Kawase triangle as an anatomical landmark for anterior petrosectomy in petroclival meningiomas.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Anterior petrosal approach: The safety of Kawase triangle as an anatomical landmark for anterior petrosectomy in petroclival meningiomas.* Clin Neurol Neurosurg. 2015 Oct 28;139:282-287 Authors: Borghei-Razavi H, Tomio R, Fereshtehnejad SM, Shibao S, Schick U, Toda M, Kawase T, Yoshida K Abstract OBJECT: Anterior petrosectomy through the middle fossa is a well-described option for addressing cranial base lesions of the petroclival region. To access posterior fossa through middle fossa, we quantitatively evaluate the safety of Kawase triangle as an anatomical landmark. METHOD: We... περισσότερα »

Temporomandibular joint disorder from skull-base osteomyelitis: a case report.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Temporomandibular joint disorder from skull-base osteomyelitis: a case report.* Maxillofac Plast Reconstr Surg. 2015 Dec;37(1):39 Authors: Lee SC, Kim JH, Kim CH, Kim BJ Abstract Skull-base osteomyelitis is a rare disease affecting the medulla of the temporal, sphenoid, and occipital bones. In general, it occurs due to external ear canal infections caused by malignant external otitis. Skull-base osteomyelitis usually affects elderly diabetic patients. The patient, a 58-year-old man, was referred for evaluation and management of the left jaw. Clinical examination of the patient ... περισσότερα »

Cost-Effectiveness Analysis of Microscopic and Endoscopic Transsphenoidal Surgery versus Medical Therapy in the Management of Microprolactinoma in the United States.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Cost-Effectiveness Analysis of Microscopic and Endoscopic Transsphenoidal Surgery versus Medical Therapy in the Management of Microprolactinoma in the United States.* World Neurosurg. 2015 Nov 5; Authors: Jethwa PR, Patel TD, Hajart AF, Eloy JA, Couldwell WT, Liu JK Abstract BACKGROUND: Although prolactinomas are effectively treated with dopamine agonists, some have proposed curative surgical resection for select cases of microprolactinomas to avoid life-long medical therapy. We performed a cost-effectiveness analysis comparing transsphenoidal surgery (either microsurgical or e...περισσότερα »

[Morphology and phenomenology of crossbow injuries with a review of the literature].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*[Morphology and phenomenology of crossbow injuries with a review of the literature].* Arch Kriminol. 2014 Nov-Dec;234(5-6):154-65 Authors: Kernbach-Wighton G, Madea B Abstract This paper presents two cases of survived and fatal injuries caused by broad-head arrows. Case no. 1 is characterised by repeated assaults resulting in severe injuries to the legs of the victim. The lesions showed characteristic patterns due to the arrow-heads with four cross-shaped blades. Case no. 2 represented a suicide with the crossbow arrow entering the upper mouth region at close range, penetrating... περισσότερα »

Challenges in Histologic Diagnosis of Nonchordomatous Lesions of the Clivus.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

[image: http:--archotol.jamanetwork.com-images-P] Related Articles *Challenges in Histologic Diagnosis of Nonchordomatous Lesions of the Clivus.* JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):745-50 Authors: Kristin J, Schipper JH, Jalkhi M, Zahnert T, Wagenmann M Abstract IMPORTANCE: Nonchordomatous clival lesions are rare and represent a wide range of different benign and malignant pathologies. For an accurate and specific final diagnosis, biopsy procedures and/or resections followed by histologic examination are mandatory. OBJECTIVE: To illustrate the challenges in obtaining... περισσότερα »

Measurement of Voluntary Cough Production and Airway Protection in Parkinson Disease.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Measurement of Voluntary Cough Production and Airway Protection in Parkinson Disease.* Arch Phys Med Rehabil. 2015 Nov 6; Authors: Silverman EP, Carnaby-Mann G, Singletary F, Hoffman-Ruddy B, Yeager J, Sapienza C Abstract OBJECTIVE: To examine relationships between Peak expiratory (cough) airflow rate and swallowing symptom severity in participants with Parkinson Disease DESIGN: Participants were cued to cough into an analog peak flow meter then swallowed three, 20 mL thin liquid barium boluses. Analyses were directed at detecting potential relationships among disease severity,... περισσότερα »

Tongue acupuncture in treatment of post-stroke dysphagia.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Tongue acupuncture in treatment of post-stroke dysphagia.* Int J Clin Exp Med. 2015;8(8):14090-4 Authors: Cai H, Ma B, Gao X, Gao H Abstract Tongue acupuncture is a technique that treats illness through acupuncture applied to the tongue. This study was designed to assess its therapeutic effects in the treatment of post-stroke dysphagia. A clinical control study was conducted with randomly selected 180 patients with post-stroke dysphagia. The patients were assigned into 2 groups: 90 in the Tongue acupuncture group received tongue acupuncture on the basis of conventional medicati... περισσότερα »

Self-perceived memory loss is associated with an increased risk of hip fracture in the elderly: a population-based NOREPOS cohort study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

BMC Geriatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRsfn via IFTTT

Double blind randomised controlled trial: injection of autologous blood in the treatment of chronic patella tendinopathy—a pilot study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

British Journal of Sports Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRqnQ via IFTTT

Factors associated with variation in urgency of primary out-of-hours contacts in the Netherlands: a cross-sectional study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

BMJ Open from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiXGx via IFTTT

Cognitive and physical symptoms of concussive injury in children: a detailed longitudinal recovery study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

British Journal of Sports Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRqnG via IFTTT

Prediction of persistent post-concussion symptoms in youth using a neuroimaging decision rule

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

Academic Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiZhB via IFTTT

Prospective use of a neuromuscular screening tool to determine risk of athletic injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

British Journal of Sports Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRpQI via IFTTT

Large national study shows little difference between ‘old’ and ‘new’ CPR in cardiac arrest

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

UAB Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiXq6 via IFTTT

The effect of early surgery after hip fracture on 1-year mortality

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

BMC Geriatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiZ1h via IFTTT

Cross-sectional study of the association between functional status and acute kidney injury in geriatric patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

BMC Nephrology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRm7p via IFTTT

Measuring the relationship between interruptions, multitasking and prescribing errors in an emergency department: a study protocol

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

BMJ Open from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRm7j via IFTTT

“Like a dialogue”: Teach-back in the emergency department

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

Patient Education and Counselling from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiZ12 via IFTTT

Contact isolation is a risk factor for venous thromboembolism in trauma patients

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 20 ώρες

The Journal of Trauma and Acute Care Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20JiX9r via IFTTT

The genome in three dimensions: a new frontier in human brain research.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *The genome in three dimensions: a new frontier in human brain research.* Biol Psychiatry. 2014 Jun 15;75(12):961-9 Authors: Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S Abstract Less than 1.5% of the human genome encodes protein. However, vast portions of the human genome are subject to transcriptional and epigenetic regulation, and many noncoding regulatory DNA elements are thought to regulate the spatial organization of interpha...περισσότερα »

Are dietary antioxidant intake indices correlated to oxidative stress and inflammatory marker levels?

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

Related Articles *Are dietary antioxidant intake indices correlated to oxidative stress and inflammatory marker levels?* Antioxid Redox Signal. 2015 Apr 10;22(11):951-9 Authors: Luu HN, Wen W, Li H, Dai Q, Yang G, Cai Q, Xiang YB, Gao YT, Zheng W, Shu XO Abstract Epidemiologic and experimental studies have shown that a high intake of individual dietary antioxidants is associated with a reduced risk of cancers. Few studies, however, have investigated the influences of a combination of dietary antioxidants. We evaluated the association of two dietary antioxidant indices, the Dieta...περισσότερα »

Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion.* J Neurol Neurosurg Psychiatry. 2015 Sep;86(9):986-95 Authors: Obayashi M, Stevanin G, Synofzik M, Monin ML, Duyckaerts C, Sato N, Streichenberger N, Vighetto A, Desestret V, Tesson C, Wichmann HE, Illig T, Huttenlocher J, Kita Y, Izumi Y, Mizusawa H, Schöls L, Klopstock T, Brice A, Ishikawa K, Dürr A Abstract OBJECTIVE: Spinocerebellar ataxia 36 (SCA36) is an autosomal-dominant neurod... περισσότερα »

Interpolated average CT for PET attenuation correction in different lesion characteristics.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Interpolated average CT for PET attenuation correction in different lesion characteristics.* Nucl Med Commun. 2015 Nov 6; Authors: Ho CY, Wu TH, Mok GS Abstract OBJECTIVE: Previously we proposed using an interpolated average computed tomography (IACT) method as a low-dose alternate of cine average computed tomography (CACT) for PET attenuation correction (AC). This study aims to evaluate its performance for thoracic lesions with different characteristics in simulations and clinical patients. MATERIALS AND METHODS: We used the XCAT phantom to simulate noisy fluorine-18 fluorodeo...περισσότερα »

Angiogenesis inhibitor; +17 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2015/11/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 1 via ola Kala on Inoreader http://ift.tt/QGMHBq(((Angiogenesis%20inhibitor)%20AND%20%222015%2F11%2F09%2007.30%22%5BMHDA%5D%3A%222015%2F11%2F1... περισσότερα »

The cyclic GMP/protein kinase g pathway as a therapeutic target in head and neck squamous cell carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*The cyclic GMP/protein kinase g pathway as a therapeutic target in head and neck squamous cell carcinoma.* Cancer Lett. 2015 Nov 6; Authors: Tuttle TR, Mierzwa ML, Wells SI, Fox SR, Ben-Jonathan N Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive disease with high mortality. Treatments, which can result in significant morbidity, have not substantially changed in three decades. The second messenger cyclic GMP (cGMP), which targets protein kinase G (PKG), is generated by guanylate cyclases (GCs), and is rapidly hydrolyzed by phosphodiesterases (PDEs). Activa...περισσότερα »

FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma.* Pathobiology. 2015 Nov 10;82(6):280-289 Authors: Koole K, van Kempen PM, van Bockel LW, Smets T, van der Klooster Z, Dutman AC, Peeters T, Koole R, van Diest P, van Es RJ, Willems SM Abstract OBJECTIVE: The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcin...περισσότερα »

Revealing the function of a novel splice-site mutation of CHD7 in CHARGE syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Revealing the function of a novel splice-site mutation of CHD7 in CHARGE syndrome.* Gene. 2015 Nov 6; Authors: Lee B, Duz MB, Sagong B, Koparir A, Lee KY, Choi JY, Seven M, Yuksel A, Kim UK, Ozen M Abstract Most cases of CHARGE syndrome are sporadic and autosomal dominant. CHD7 is a major causative gene of CHARGE syndrome. In this study, we screened CHD7 in two Turkish patients who had CHARGE syndrome symptoms as coloboma, heart defect, choanal atresia, retarded growth and ear anomalies and found a novel splice-site mutation (c.2443-2A>G) and a previously known frameshift muta... περισσότερα »

Conchal compression: is it a new syndrome?

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Conchal compression: is it a new syndrome?* Int J Clin Exp Med. 2015;8(8):14440-6 Authors: Kutluhan A, Demir MK, Bozdemir K, Callioglu EE Abstract OBJECTIVES/HYPOTHESIS: To describe the diagnostic criteria and treatments of concha compression syndrome (CCS). PATIENTS AND METHODS: Patients who reported at least 3 times rhinosinusitis attacks per year were considered in this study. All patients met the diagnosis criteria of rhinosinusitis based on clinical history, showed a nasal septal spur compressing concha on their endoscopic examination and had no findings of rhinosinusitis o... περισσότερα »

Efficacy of methylprednisolone sodium succinate for injection (postotic injection) on the auditory threshold and speech recognition rate of sudden deafness patients.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Efficacy of methylprednisolone sodium succinate for injection (postotic injection) on the auditory threshold and speech recognition rate of sudden deafness patients.* Int J Clin Exp Med. 2015;8(8):14110-4 Authors: Li X, Zhang XY, Wang QJ, Wang DY Abstract OBJECTIVE: To investigate the effect of injecting the methylprednisolone in the ear for the sudden deafness and the improvement of speech discrimination test. METHODS: 50 inpatients with a sudden hearing loss were recruited. Inject the methylprednisolone in the subperiosteal of the ear which is 0.5 cm distance to the ear ditch...περισσότερα »

Expression of purinergic receptor P2Y4 in Schwann cell following nerve regeneration.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Expression of purinergic receptor P2Y4 in Schwann cell following nerve regeneration.* Int J Clin Exp Med. 2015;8(8):13203-10 Authors: Chen S, Xia S, Sun Y, Li M, Song X, Li G, Zheng H, Chen D Abstract OBJECTIVE: Emerging evidences suggested an important role of purinergic receptor P2Y4 in nerve system. The present study aims to investigate the localization and possible function of P2Y4 receptor in recurrent laryngeal nerve (RLN) following regeneration. METHODS: Right RLN of fifty Sprague-Dawley rats was cut and immediately repaired with PLGA/chitosan nerve conduit. Immunofluores... περισσότερα »

Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.* Int J Clin Exp Med. 2015;8(8):13028-38 Authors: Zhang Y, Xu H, Shen Y, Gong Z, Xiao T Abstract Numerous studies have explored the association of polymorphisms in the DNA methyltransferase 3b (DNMT3B) gene with the risk of different types of cancer, but yielded controversial results. Therefore, we performed a meta-analysis to derive a more precise estimation of the association between three widely-studied DNMT3B polymorphisms and overall cancer susceptibility... περισσότερα »

The role of great auricular-facial nerve neurorrhaphy in facial nerve damage.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*The role of great auricular-facial nerve neurorrhaphy in facial nerve damage.* Int J Clin Exp Med. 2015;8(8):12970-6 Authors: Sun Y, Liu L, Han Y, Xu L, Zhang D, Wang H Abstract BACKGROUND: Facial nerve is easy to be damaged, and there are many reconstructive methods for facial nerve reconstructive, such as facial nerve end to end anastomosis, the great auricular nerve graft, the sural nerve graft, or hypoglossal-facial nerve anastomosis. However, there is still little study about great auricular-facial nerve neurorrhaphy. The aim of the present study was to identify the role o... περισσότερα »

Carcinoma of unknown primary in the head and neck: The evaluation of the effectiveness of (18)F-FDG-PET/CT, own experience.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Carcinoma of unknown primary in the head and neck: The evaluation of the effectiveness of (18)F-FDG-PET/CT, own experience.* Rep Pract Oncol Radiother. 2015 Sep-Oct;20(5):393-7 Authors: Majchrzak E, Cholewiński W, Golusiński W Abstract AIM: The aim of the present study was to estimate the clinical effectiveness of (18)F-FDG-PET/CT in the detection of the primary tumor in patients with histologically proven squamous cell carcinoma cervical lymph nodes metastasis from an unknown primary. BACKGROUND: (18)F-fluorodeoxyglucose positron emission tomography combined with CT ((18)F-FDG-... περισσότερα »

Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature.* Rep Pract Oncol Radiother. 2015 Sep-Oct;20(5):328-39 Authors: González Ferreira JA, Jaén Olasolo J, Azinovic I, Jeremic B Abstract Treatment delays in completing radiotherapy (RT) for many neoplasms are a major problem affecting treatment outcome, as increasingly shown in the literature. Overall treatment time (OTT) could be a critical predictor of local tumor control and/or survival. In an attempt to establish a protocol for managing delays du... περισσότερα »

Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.* Acta Otolaryngol. 2015 Nov 7;:1-5 Authors: Omichi R, Maeda Y, Sugaya A, Kataoka Y, Kariya S, Nagayasu R, Nakagawa A, Yamashita T, Abe K, Nishizaki K Abstract CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance...περισσότερα »

What more can be done to popularize phonosurgical ideas in everyday handling of vocal folds?

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*What more can be done to popularize phonosurgical ideas in everyday handling of vocal folds?* Otolaryngol Pol. 2015 Nov 10;69(6):1-10 Authors: Wierzbicka M, Sjogren EV, Dikkers FG Abstract This paper is focused on vocal fold surgery with phonosurgical intent. The aim of this review is to broaden phonosurgical knowledge, spread the ideas of the European Laryngological Society (ELS) on phonosurgery and translate the layered structure and physiology of the vocal fold described in Hirano's classic body-cover model into the graphic illustration of the "fluttering sleeve" created by ... περισσότερα »

The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*The anti-tumour activity of rLj-RGD4, an RGD toxin protein from Lampetra japonica, on human laryngeal squamous carcinoma Hep-2 cells in nude mice.* Biochimie. 2015 Nov 5; Authors: Shao F, Lv M, Zheng Y, Jiang J, Wang Y, Lv L, Wang J Abstract PURPOSE: The objective of this study is to investigate the antiproliferative activity and mechanism of integrin-binding rLj-RGD4 in a Hep-2 human laryngeal carcinoma-bearing nude mouse model. METHODS: Human laryngeal squamous carcinoma cells (Hep-2) were inoculated subcutaneously into the axilla of nude mice to generate a Hep-2 human larynge... περισσότερα »

Oral Surgical Procedures Performed Safely in Patients With Head and Neck Arteriovenous Malformations: A Retrospective Case Series of 12 Patients.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Oral Surgical Procedures Performed Safely in Patients With Head and Neck Arteriovenous Malformations: A Retrospective Case Series of 12 Patients.* J Oral Maxillofac Surg. 2015 Oct 23; Authors: Karim AB, Paramasivam S, Bovino B, Berenstein A Abstract PURPOSE: This case series describes patients with head and neck arteriovenous malformations who underwent oral and maxillofacial surgical procedures combined with interventional radiology techniques to minimize blood loss. MATERIALS AND METHODS: Twelve patients underwent femoral cerebral angiography to visualize the extent of vascula... περισσότερα »

The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*The Stereociliary Paracrystal Is a Dynamic Cytoskeletal Scaffold In Vivo.* Cell Rep. 2015 Nov 4; Authors: Hwang P, Chou SW, Chen Z, McDermott BM Abstract Permanency of mechanosensory stereocilia may be the consequence of low protein turnover or rapid protein renewal. Here, we devise a system, using optical techniques in live zebrafish, to distinguish between these mechanisms. We demonstrate that the stereocilium's abundant actin cross-linker fascin 2b exchanges, without bias or a phosphointermediate, orders of magnitude faster (t1/2 of 76.3 s) than any other known hair bundle p...περισσότερα »

Mechanisms for the Generation of Two Quadruplications Associated with Split-Hand Malformation.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Mechanisms for the Generation of Two Quadruplications Associated with Split-Hand Malformation.* Hum Mutat. 2015 Nov 9; Authors: Gu S, Posey JE, Yuan B, Carvalho CM, Luk HM, Erikson K, Lo IF, Leung GK, Pickering CR, Chung BH, Lupski JR Abstract Germline copy-number variants (CNVs) involving quadruplications are rare and the mechanisms generating them are largely unknown. Previously, we reported a 20-week gestation fetus with split-hand malformation; clinical microarray detected two maternally inherited triplications separated by a copy-number neutral region at 17p13.3, involving...περισσότερα »

A 7666-bp genomic deletion is frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*A 7666-bp genomic deletion is frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations.* Int J Pediatr Otorhinolaryngol. 2015 Oct 23; Authors: Pang X, Chai Y, He L, Chen P, Wang X, Li L, Jia H, Wu H, Yang T Abstract OBJECTIVES: To investigate the genetic cause of the patients with non-syndromic enlarged vestibular aqueduct (EVA) but without bi-allelic SLC26A4 mutations. METHODS: Presence of a homozygous genomic deletion was detected in a Chinese Han deaf patient (D1467-1) who failed to amplify the first three ...περισσότερα »

A review of manual wheelchairs.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*A review of manual wheelchairs.* Disabil Rehabil Assist Technol. 2015 Nov 7;:1-11 Authors: Flemmer CL, Flemmer RC Abstract PURPOSE: To review the scientific literature published in the last 14 years on the different types of manual wheelchairs. METHOD: A systematic review of the literature was conducted to find the recent research on manual wheelchairs. RESULTS: The findings of 77 references on pushrim-propelled wheelchairs, crank-propelled wheelchairs, lever-propelled wheelchairs, geared manual wheelchairs and pushrim-activated power-assist wheelchairs are reported. CONCLUSION: ... περισσότερα »

Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy.* Acta Otolaryngol. 2015 Nov 7;:1-5 Authors: Omichi R, Maeda Y, Sugaya A, Kataoka Y, Kariya S, Nagayasu R, Nakagawa A, Yamashita T, Abe K, Nishizaki K Abstract CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance...περισσότερα »

Improved method of gastrostomy tube replacement using a small-caliber transnasal endoscope.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Improved method of gastrostomy tube replacement using a small-caliber transnasal endoscope.* Acta Otolaryngol. 2015 Nov 7;:1-4 Authors: Chang H, Huang Y, Yao W, Zhang L, Li Y Abstract CONCLUSION: Gastrostomy tube replacement using a new approach through the abdominal-wall stoma with a small-caliber trans-nasal endoscope is feasible, fast, and safe compared with the trans-oral approach. OBJECTIVES: To evaluate the feasibility of a new technique using a trans-nasal endoscope for gastrostomy tube replacement. METHODS: Between June 2005 and December 2013 in the Peking University Thir... περισσότερα »

Prognostic value of psychological state in cochlear implantation.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 20 ώρες

*Prognostic value of psychological state in cochlear implantation.* Acta Otolaryngol. 2015 Nov 7;:1-5 Authors: Han JJ, Shin MS, Song JJ, Pai I, Oh S, Kim B, Park JH, Lee JH, Oh SH Abstract CONCLUSION: Perioperative Minnesota Multiphasic Personality Inventory (MMPI) scores may be beneficial for predicting prognosis of cochlear implantation (CI). A positive attitude for social interaction in particular correlates with a better speech outcome. Proper perioperative psychological management may, therefore, assist in the auditory rehabilitation of CI patients. OBJECTIVE: To determine ... περισσότερα »

A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma.* Cancer Treat Rev. 2015 Oct 28; Authors: Zanoletti E, Lovato A, Stritoni P, Martini A, Mazzoni A, Marioni G Abstract Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding the rational diagnostic/therapeutic approach to TBSCC. Diagnostic differences are due mainly to: the small number of cases reported (even in the largest available series); the inappropriate hi... περισσότερα »

Future Oncology; +41 new citations

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

41 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Future Oncology* These pubmed results were generated on 2015/11/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 3 via ola Kala on Inoreader http://ift.tt/QGMHBq(((Future%20Oncology)%20AND%20%222015%2F11%2F09%2006.01%22%5BMHDA%5D%3A%222015%2F11%2F10%2006.15%22%5... περισσότερα »

ATP Synthase Deficiency due to TMEM70 Mutation Leads to Ultrastructural Mitochondrial Degeneration and Is Amenable to Treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*ATP Synthase Deficiency due to TMEM70 Mutation Leads to Ultrastructural Mitochondrial Degeneration and Is Amenable to Treatment.* Biomed Res Int. 2015;2015:462592 Authors: Braczynski AK, Vlaho S, Müller K, Wittig I, Blank AE, Tews DS, Drott U, Kleinle S, Abicht A, Horvath R, Plate KH, Stenzel W, Goebel HH, Schulze A, Harter PN, Kieslich M, Mittelbronn M Abstract TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four sibli... περισσότερα »

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness.* Oncogene. 2015 Nov 9; Authors: Schulze M, Fedorchenko O, Zink TG, Knobbe-Thomsen CB, Kraus S, Schwinn S, Beilhack A, Reifenberger G, Monoranu CM, Sirén AL, Jeanclos E, Gohla A Abstract Glioblastoma is the most aggressive primary brain tumor in adults. Although the rapid recurrence of glioblastomas after treatment is a major clinical challenge, the relationships between tumor growth and intracerebral spread remain poorly understood. We have identified the cofilin phosphatase...περισσότερα »

Choline Kinase Beta-Related Muscular Dystrophy, Appearance of Muscle Involvement on Magnetic Resonance Imaging.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

*Choline Kinase Beta-Related Muscular Dystrophy, Appearance of Muscle Involvement on Magnetic Resonance Imaging.* Pediatr Neurol. 2015 Nov 5; Authors: De Goede C, Oh T, Joseph J, Muntoni F, Sewry C, Phadke R Abstract BACKGROUND: Clinical presentation with motor delay, proximal weakness, and learning difficulties will raise the possibility of a dystrophinopathy, dystroglycanopathy, or myotonic dystrophy. This differential should also include the more recently described choline kinase beta-related muscular dystrophy. This condition is typically characterized by large and abnormall...περισσότερα »

Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions.

Alexandros G. SfakianakisστοHead and NeckΠριν από 20 ώρες

[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions.* Oncotarget. 2014 Dec 30;5(24):12573-92 Authors: Schütze S, Ribes S, Kaufmann A, Manig A, Scheffel J, Redlich S, Bunkowski S, Hanisch UK, Brück W, Nau R Abstract Incidence and mortality of bacterial meningitis are strongly increased in aged compared to younger adults demanding new strategies to impr... περισσότερα »

IJERPH, Vol. 12, Pages 14301-14311: Exposure to Air Ions in Indoor Environments: Experimental Study with Healthy Adults

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Since the beginning of the 20th century there has been a scientific debate about the potential effects of air ions on biological tissues, wellbeing and health. Effects on the cardiovascular and respiratory system as well as on mental health have been described. In recent years, there has been a renewed interest in this topic. In an experimental indoor setting we conducted a double-blind cross-over trial to determine if higher levels of air ions, generated by a special wall paint, affect cognitive performance, wellbeing, lung function, and cardiovascular function. Twenty healthy no... περισσότερα »

IJERPH, Vol. 12, Pages 14285-14300: Arsenic and Other Metals’ Presence in Biomarkers of Cambodians in Arsenic Contaminated Areas

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Chemical analyses of metal (Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Mo, Ba, and Pb) concentrations in hair, nails, and urine of Cambodians in arsenic-contaminated areas who consumed groundwater daily showed elevated levels in these biomarkers for most metals of toxicological interest. The levels of metals in biomarkers corresponded to their levels in groundwater, especially for As, whose concentrations exceeded the WHO guidelines for drinking water. About 75.6% of hair samples from the population in this study contained As levels higher than the normal level in unexposed individuals (1 mg... περισσότερα »

IJMS, Vol. 16, Pages 26832-26849: Single-Cell Isolation and Gene Analysis: Pitfalls and Possibilities

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

During the last two decades single-cell analysis (SCA) has revealed extensive phenotypic differences within homogenous cell populations. These phenotypic differences are reflected in the stochastic nature of gene regulation, which is often masked by qualitatively and quantitatively averaging in whole tissue analyses. The ability to isolate transcripts and investigate how genes are regulated at the single cell level requires highly sensitive and refined methods. This paper reviews different strategies currently used for SCA, including harvesting, reverse transcription, and amplific... περισσότερα »

Drug Delivery Using Novel Biological and Synthetic Materials

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

from #Medicine via ola Kala on Inoreader http://ift.tt/1RKvtQ3 via IFTTT

Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases: Rationale, Aims, and Design of a Nationwide Prospective Registry—The EXCITING-ILD Registry

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Despite a number of prospective registries conducted in past years, the current epidemiology of interstitial lung diseases (ILD) is still not well defined, particularly regarding the prevalence and incidence, their management, healthcare utilisation needs, and healthcare-associated costs. To address these issues in Germany, a new prospective ILD registry, "Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases" (EXCITING-ILD), is being conducted by the German Centre for Lung Research in association with ambulatory, inpatient, scientific pulmonology or... περισσότερα »

Changes of Plantar Pressure and Gait Parameters in Children with Mild Cerebral Palsy Who Used a Customized External Strap Orthosis: A Crossover Study

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Toe-in gait and crouch gait can make children with mild cerebral palsy fall and suffer improper balance during walking or ambulation training. A customized external strap orthosis for correcting leg alignment was used to resolve this problem. The purpose of this study was to research the immediate effects while wearing the customized external strap orthosis. Pressure platform was used to assess the plantar pressure through static and dynamic assessments and to record the changes in path of pressure trajectory. Motion image analysis system was used to record the gait parameters, wh... περισσότερα »

Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Introduction. Senescence of peritoneal mesothelial cells represents a biological program defined by arrested cell growth and altered cell secretory phenotype with potential impact in peritoneal dialysis. This study aims to characterize cellular senescence at the level of global protein expression profiles and modification of proteins with O-linked N-acetylglucosamine (O-GlcNAcylation). Methods. A comparative proteomics analysis between young and senescent human peritoneal mesothelial cells (HPMC) was performed using two-dimensional gel electrophoresis. O-GlcNAc status was assessed...περισσότερα »

Selection of the Strain Lactobacillus acidophilus ATCC 43121 and Its Application to Brewers’ Spent Grain Conversion into Lactic Acid

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

Six Lactobacillus strains were analyzed to select a bacterium for conversion of brewers' spent grain (BSG) into lactic acid. Among the investigated strains, L. acidophilus ATCC 43121 showed the highest yield of lactic acid production (16.1 g/L after 48 hours) when grown in a synthetic medium. It was then analyzed for its ability to grow on the hydrolysates obtained from BSG after acid-alkaline (AAT) or aqueous ammonia soaking (AAS) pretreatment. The lactic acid production by L. acidophilus ATCC 43121 through fermentation of the hydrolysate from AAS treated BSG was 96% higher than ...περισσότερα »

Cancers, Vol. 7, Pages 2262-2276: Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 ώρες

A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective s...περισσότερα »

[Obstructive Sleep Apnea: review and a case presentation].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*[Obstructive Sleep Apnea: review and a case presentation].* Refuat Hapeh Vehashinayim (1993). 2015 Jul;32(3):6-15, 66 Authors: Fleissig Y, Laviv A, Peacock ZS, Casap N Abstract Obstructive sleep apnea may be a life threatening situation if does not get proper attention. Risk factors are easy to find, therefore general dental surgeons should be aware of them and refer if needed. This literature review clearly explains how obstructive sleep apnea is diagnosed and treated. We present a case of a patient with severe obstructive sleep apnea (apnea hypopnea index of 87.5/hour), who un... περισσότερα »

Indeterminate Single Thyroid Nodule: Synergistic Impact of Mutational Markers and Sonographic Features in Triaging Patients to Appropriate Surgery.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Indeterminate Single Thyroid Nodule: Synergistic Impact of Mutational Markers and Sonographic Features in Triaging Patients to Appropriate Surgery.* Thyroid. 2015 Nov 8; Authors: De Napoli L, Bakkar S, Ambrosini CE, Materazzi G, Proietti A, Macerola E, Basolo F, Miccoli P Abstract BACKGROUND: Patients labeled as having indeterminate thyroid nodular disease following fine needle aspiration cytology are at risk of non-optimal initial surgery: an overly radical total thyroidectomy, or an unnecessary two stage operation. The objective of this study was to assess the impact of comb...περισσότερα »

Dorsal and Ventral Pathways for Prosody.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Dorsal and Ventral Pathways for Prosody.* Curr Biol. 2015 Nov 4; Authors: Sammler D, Grosbras MH, Anwander A, Bestelmeyer PE, Belin P Abstract Our vocal tone-the prosody-contributes a lot to the meaning of speech beyond the actual words. Indeed, the hesitant tone of a "yes" may be more telling than its affirmative lexical meaning [1]. The human brain contains dorsal and ventral processing streams in the left hemisphere that underlie core linguistic abilities such as phonology, syntax, and semantics [2-4]. Whether or not prosody-a reportedly right-hemispheric faculty [5, 6]-invo...περισσότερα »

Effect of Endotracheal Tube Size on Vocal Outcomes After Thyroidectomy: A Randomized Clinical Trial.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

[image: http:--archotol.jamanetwork.com-images-P] Related Articles *Effect of Endotracheal Tube Size on Vocal Outcomes After Thyroidectomy: A Randomized Clinical Trial.* JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):690-5 Authors: Mehanna R, Hennessy A, Mannion S, O'Leary G, Sheahan P Abstract IMPORTANCE: The optimum size of endotracheal tube (ETT) for general anesthesia remains unresolved. Choice of ETT size may be of particular relevance to thyroid surgery because of the increased risk of laryngeal trauma and concerns regarding postoperative vocal outcomes. OBJECTIVE: To test... περισσότερα »

Voice Outcomes Following Posterior Cordotomy With Medial Arytenoidectomy in Patients With Bilateral Vocal Fold Immobility.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

[image: http:--archotol.jamanetwork.com-images-P] Related Articles *Voice Outcomes Following Posterior Cordotomy With Medial Arytenoidectomy in Patients With Bilateral Vocal Fold Immobility.* JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):728-32 Authors: Hillel AT, Giraldez L, Samad I, Gross J, Klein AM, Johns MM Abstract IMPORTANCE: Voice quality-of-life (VQOL) and perceptual voice outcomes are presumed to worsen following posterior cordotomy with medial arytenoidectomy for bilateral vocal fold immobility (BVFI); however, subjective and objective voice outcomes are not well stu... περισσότερα »

Predictors of Intensive Care Unit Stay After Pediatric Supraglottoplasty.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

[image: http:--archotol.jamanetwork.com-images-P] Related Articles *Predictors of Intensive Care Unit Stay After Pediatric Supraglottoplasty.* JAMA Otolaryngol Head Neck Surg. 2015 Aug;141(8):704-9 Authors: Albergotti WG, Sturm JJ, Stapleton AS, Simons JP, Mehta DK, Chi DH Abstract IMPORTANCE: Supraglottoplasty is a common procedure performed without evidence-based postoperative management plans. Patients are routinely admitted to the intensive care unit (ICU) postoperatively, but this may not be necessary in all cases. OBJECTIVE: To determine (1) whether routine admission to the I... περισσότερα »

Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.* PLoS One. 2014;9(8):e104432 Authors: Feretzaki M, Hardison SE, Wormley FL, Heitman J Abstract Cryptococcus neoformans is a human fungal pathogen that causes lethal infections of the lung and central nervous system in immunocompromised individuals. C. neoformans has a defined bipolar sexual life cycle with a and α mating types. During the sexual cycle, which can occur b... περισσότερα »

Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas.* Oncotarget. 2014 Dec 30;5(24):12593-606 Authors: Liu Y, Hu H, Wang K, Zhang C, Wang Y, Yao K, Yang P, Han L, Kang C, Zhang W, Jiang T Abstract Malignant progression of astrocytoma is a multistep process with the integration of genetic abnormalities including grade progression and subtypes transition. Established biomarkers of astrocytomas, like IDH1 and TP53 mu... περισσότερα »

Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Brain biopsy findings link major depressive disorder to neuroinflammation, oxidative stress, and neurovascular dysfunction: a case report.* Biol Psychiatry. 2014 Jun 15;75(12):e23-6 Authors: Najjar S, Pearlman DM, Hirsch S, Friedman K, Strange J, Reidy J, Khoukaz M, Ferrell RB, Devinsky O, Najjar A, Zagzag D PMID: 24075735 [PubMed - indexed for MEDLINE] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1Mm0d6e via IFTTT

[Successful treatment with rituximab and romiplostim for thrombocytopenia associated with Waldenström's macroglobulinemia initially presenting as Evans syndrome].

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--linkout.jstage.jst.go.jp-logo_non] Related Articles *[Successful treatment with rituximab and romiplostim for thrombocytopenia associated with Waldenström's macroglobulinemia initially presenting as Evans syndrome].* Rinsho Ketsueki. 2015 Mar;56(3):317-22 Authors: Nozaki Y, Koshiishi M, Sueki Y, Kawashima I, Yamamoto T, Nakajima K, Mitsumori T, Kirito K Abstract A 60-year-old woman was admitted to our hospital with anemia and thrombocytopenia. Serum testing showed platelet-associated IgG elevation and she was positive on the direct and indirect Coombs tests. Togeth...περισσότερα »

Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--production.springer.de-OnlineReso] Related Articles *Sporadic meningioangiomatosis with and without meningioma: analysis of clinical differences and risk factors for poor seizure outcomes.* Acta Neurochir (Wien). 2015 May;157(5):841-53; discussion 853 Authors: Zhang C, Wang Y, Wang X, Zhang JG, Li JJ, Hu WH, Zhang K Abstract BACKGROUND: Meningioangiomatosis (MA) is a rare cerebral lesion. Sporadic MA occasionally combines with meningioma (MA-M). The aim of the present study was to clarify whether MA-M and pure MA have clinical differences and to determine risk facto... περισσότερα »

Life-threatening angiomyxoma of the larynx.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Life-threatening angiomyxoma of the larynx.* Ethiop J Health Sci. 2015 Jan;25(1):105-7 Authors: Yaman H, Erdem H, Belada A, Besir FH, Oktay M, Uzunlar AK Abstract BACKGROUND: Angiomyxoma is a benign proliferative mesenchymal tumor and a very rare mass in the larynx. There is not enough information about the etiology, clinical finding, treatment and prognosis of laryngeal angiomyxoma. CASE DETAILS: A 52 years old man presented with respiratory distress. Also, he had suffered from dysphagia, dysphonia, cough, and obstructive sl... περισσότερα »

Therapeutic approach guided by genetic alteration: use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

Related Articles *Therapeutic approach guided by genetic alteration: use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression.* Cancer Biol Ther. 2015;16(1):28-33 Authors: Lipkin JS, Rizvi SM, Gatalica Z, Sarwani NE, Holder SL, Kaag M, Drabick JJ, Joshi M Abstract Renal Medullary Cancer (RMC) is a rare and aggressive type of renal cell cancer that presents predominantly in patients with sickle cell hemoglobinopathies, and is typically metastatic at the time of presentation. Although platinum based chemotherapeutic regimens have recently emerged as the best... περισσότερα »

Interdigitating dendritic cell sarcoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Interdigitating dendritic cell sarcoma.* J Natl Compr Canc Netw. 2015 Feb;13(2):128-32 Authors: Pokuri VK, Merzianu M, Gandhi S, Baqai J, Loree TR, Bhat S Abstract Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare dendritic cell tumor with slightly more than 100 cases reported in the English literature. This report discusses a case of localized IDCS involving cervical lymph nodes and provides a literature review of clinicopathologic aspects and treatment outcomes. PMID: 25691604 [PubMed - indexed... περισσότερα »

Clear cell adenocarcinoma of the urethra: review of the literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Clear cell adenocarcinoma of the urethra: review of the literature.* Int J Surg Oncol. 2015;2015:790235 Authors: Venyo AK Abstract BACKGROUND: Clear cell adenocarcinoma of the urethra (CCAU) is extremely rare and a number of clinicians may be unfamiliar with its diagnosis and biological behaviour. AIMS: To review the literature on CCAU. METHODS: Various internet databases were used. RESULTS/LITERATURE REVIEW: (i) CCAU occurs in adults and in women in the great majority of case... περισσότερα »

The use of novel agents in multiple myeloma patients with hepatic impairment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

Related Articles *The use of novel agents in multiple myeloma patients with hepatic impairment.* Future Oncol. 2015;11(3):501-10 Authors: Stansfield LC, Gonsalves WI, Buadi FK Abstract Novel drugs such as immunomodulators and proteasome inhibitors have improved the survival of patients with multiple myeloma. Like all therapeutic agents, appropriate dosing based on metabolism and clearance is important to maintain efficacy while avoiding toxicity. Hepatic impairment (HI) in multiple myeloma patients is rare but well described either due to disease or therapy-related factors. Howe...περισσότερα »

Peripheral primitive neuroectodermal tumor: dynamic CT, MRI and clinicopathological characteristics--analysis of 36 cases and review of the literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

[image: http:--http://ift.tt/1kmBV5b] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Peripheral primitive neuroectodermal tumor: dynamic CT, MRI and clinicopathological characteristics--analysis of 36 cases and review of the literature.* Oncotarget. 2014 Dec 30;5(24):12968-77 Authors: Tan Y, Zhang H, Ma GL, Xiao EH, Wang XC Abstract BACKGROUND: The peripheral primitive neuroectodermal tumor (pPNET) is a rare malignant tumor originating from neuroectoderm. The accurate diagnosis is essential for the treatment of pPNET. METHODS: we performed the largest cases of retrospect... περισσότερα »

Validity of the Special Needs Education Assessment Tool (SNEAT), a Newly Developed Scale for Children with Disabilities.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Validity of the Special Needs Education Assessment Tool (SNEAT), a Newly Developed Scale for Children with Disabilities.* Tohoku J Exp Med. 2015;237(3):241-8 Authors: Kohara A, Han C, Kwon H, Kohzuki M Abstract The improvement of the quality of life (QOL) of children with disabilities has been considered important. Therefore, the Special Needs Education Assessment Tool (SNEAT) was developed based on the concept of QOL to objectively evaluate the educational outcome of children with disabilities. SNEAT consists of 11 items in three domains: physical functioning, mental health, a... περισσότερα »

Pitfall in the Diagnosis of Fructose-1,6-Bisphosphatase Deficiency: Difficulty in Detecting Glycerol-3-Phosphate with Solvent Extraction in Urinary GC/MS Analysis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Pitfall in the Diagnosis of Fructose-1,6-Bisphosphatase Deficiency: Difficulty in Detecting Glycerol-3-Phosphate with Solvent Extraction in Urinary GC/MS Analysis.* Tohoku J Exp Med. 2015;237(3):235-9 Authors: Kato S, Nakajima Y, Awaya R, Hata I, Shigematsu Y, Saitoh S, Ito T Abstract Fructose-1,6-bisphosphatase (FBPase), an enzyme involved in gluconeogenesis, catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate. FBPase deficiency is an autosomal recessive inherited disorder, characterized by episodic attacks of hypoglycemia, ket...περισσότερα »

Intraventricular Meningioma: Technical Nuances in Surgical Management.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Intraventricular Meningioma: Technical Nuances in Surgical Management.* World Neurosurg. 2015 Nov 5; Authors: Nanda A, Bir SC, Maiti T, Konar S Abstract OBJECTIVE: Compared to intracranial meningiomas, intraventricular meningiomas (IVMs) are rare tumors. Optimal surgical management of IVMs remains controversial. The outcomes and complications of meningiomas treated with various surgical approaches were reviewed. MATERIALS AND METHODS: We performed a retrospective review of 18 patients with intraventricular meningiomas who received different treatment strategies between 2000 and ... περισσότερα »

Posterior two-level vertebral column resection for the treatment of progressive rotational dislocation in kyphoscoliotic deformities.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Posterior two-level vertebral column resection for the treatment of progressive rotational dislocation in kyphoscoliotic deformities.* World Neurosurg. 2015 Nov 5; Authors: Zhang Z, Wang H, Shangguan L Abstract OBJECTIVE: Progressive rotational dislocation of the spine is rare and challenging for surgical treatment. Few reports have described surgical decompression, fusion, and partial correction by traditional two-stage anterior decompression and posterior fixation technique. The goal of this retrospective study was to report a series of 6 patients with this deformity and the ...περισσότερα »

Incidence of idiopathic normal pressure hydrocephalus in Northern Spain.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Incidence of idiopathic normal pressure hydrocephalus in Northern Spain.* World Neurosurg. 2015 Nov 5; Authors: Martín-Láez R, Caballero-Arzapalo H, Valle-San Román N, López-Menéndez LÁ, Carlos Arango-Lasprilla J, Vázquez-Barquero A Abstract BACKGROUND: Although the incidence of idiopathic normal pressure hydrocephalus (iNPH) may be as high as 1.20 cases per 1,000 inhabitants-year in individuals aged 70 years and older, in most series, incidence of shunt-responsive iNPH seems to be less than 1/100,000 inhabitants-year. In this study, we report the results of a prospective ten-y...περισσότερα »

Quantitative Evaluation of Local Control and Wound Healing Following Surgery and Stereotactic Spine Radiosurgery (SRS) for Spine Tumors.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Quantitative Evaluation of Local Control and Wound Healing Following Surgery and Stereotactic Spine Radiosurgery (SRS) for Spine Tumors.* World Neurosurg. 2015 Nov 5; Authors: Harel R, Emch T, Chao S, Elson P, Krishnaney A, Djemil T, Suh J, Angelov L Abstract OBJECTIVE: The present study evaluated the optimal measuring criteria to assess spinal tumor response to surgery followed by Stereotactic Spine Radiosurgery (SRS) and reports the local control and wound complication rates following combined multimodality treatment. METHODS AND MATERIALS: Prospectively collected patient info... περισσότερα »

Ictal EEG Source Imaging for Presurgical Evaluation of Refractory Focal Epilepsy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Ictal EEG Source Imaging for Presurgical Evaluation of Refractory Focal Epilepsy.* World Neurosurg. 2015 Nov 5; Authors: Habib MA, Ibrahim F, Mohktar MS, Kamaruzzaman SB, Rahmat K, Lim KS Abstract BACKGROUND: EEG source imaging (ESI) is a promising tool for localizing the cortical sources of both ictal and interictal epileptic activities. Many studies have shown the clinical usefulness of interictal ESI but very few have investigated the utility of ictal ESI. The aim of this article is to examine the clinical usefulness of ictal ESI for epileptic focus localization in patients ... περισσότερα »

Assessing Patient Reported Outcomes Measures Via Phone Interviews Versus Patient Self-Survey in Clinic: Are we Measuring the Same Thing?

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Assessing Patient Reported Outcomes Measures Via Phone Interviews Versus Patient Self-Survey in Clinic: Are we Measuring the Same Thing?* World Neurosurg. 2015 Nov 5; Authors: Adogwa O, Elsamadicy AA, Cheng J, Bagley C PMID: 26548832 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1QfCXNk via IFTTT

New radiological parameters predict clinical outcome after decompressive craniectomy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*New radiological parameters predict clinical outcome after decompressive craniectomy.* World Neurosurg. 2015 Nov 5; Authors: Sauvigny T, Göttsche J, Vettorazzi E, Westphal M, Regelsberger J PMID: 26548831 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1QfCURw via IFTTT

Management of bilateral hemifacial spasm with microvascular decompression.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Management of bilateral hemifacial spasm with microvascular decompression.* World Neurosurg. 2015 Nov 5; Authors: Dou NN, Zhong J, Liu MX, Xia L, Sun H, Li B, Li ST Abstract BACKGROUND: Bilateral hemifacial spasm(BHFS) is very rare. Only about 3 dozen clinical reports have been highlighted in the literature. Although microvascular decompression (MVD) is widely accepted as the effective therapy for hemifacial spasm (HFS), the etiology and surgical treatment of BHFS is seldom addressed. Hereby, we reported our experience with MVD for those BHFS patients. METHODS: Ten cases who suf...περισσότερα »

Glioblastoma with Rhabdoid Features: Report of Two Young Adult Cases and Review of the Literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Glioblastoma with Rhabdoid Features: Report of Two Young Adult Cases and Review of the Literature.* World Neurosurg. 2015 Nov 5; Authors: Miyahara M, Nobusawa S, Inoue M, Okamoto K, Mochizuki M, Hara T Abstract BACKGROUND: There are few previous reports of glioblastoma in young adults, in particular, of the very rare recently proposed rhabdoid or epithelioid types. CASE DESCRIPTIONS: We report two cases of glioblastoma with rhabdoid features involving a 27-year-old woman and a 41-year-old man. In Case 1, the patient presented with generalized seizures, and the initial magnetic ...περισσότερα »

Cost-Effectiveness Analysis of Microscopic and Endoscopic Transsphenoidal Surgery versus Medical Therapy in the Management of Microprolactinoma in the United States.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Cost-Effectiveness Analysis of Microscopic and Endoscopic Transsphenoidal Surgery versus Medical Therapy in the Management of Microprolactinoma in the United States.* World Neurosurg. 2015 Nov 5; Authors: Jethwa PR, Patel TD, Hajart AF, Eloy JA, Couldwell WT, Liu JK Abstract BACKGROUND: Although prolactinomas are effectively treated with dopamine agonists, some have proposed curative surgical resection for select cases of microprolactinomas to avoid life-long medical therapy. We performed a cost-effectiveness analysis comparing transsphenoidal surgery (either microsurgical or e...περισσότερα »

Intraoperative evaluation of reverse bypass using a naturally formed "bonnet" superficial temporal artery: Technical note.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Intraoperative evaluation of reverse bypass using a naturally formed "bonnet" superficial temporal artery: Technical note.* World Neurosurg. 2015 Nov 5; Authors: Nagm A, Horiuchi T, Hasegawa T, Hongo K Abstract BACKGROUND: In reverse bypass using a naturally formed "bonnet" superficial temporal artery (STA), intraoperative volume flow measurement quantifies flow augmentation after revascularization, confirms flow preservation and identifies inadvertent vessel compromise. CASE DESCRIPTION: Herein the authors present a case of 75-year-old man with transient ischemic attacks, attri...περισσότερα »

Penetration of an Optic Nerve by a Sellar/Suprasellar Arachnoid Cyst.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Penetration of an Optic Nerve by a Sellar/Suprasellar Arachnoid Cyst.* World Neurosurg. 2015 Nov 5; Authors: Dawkins RL, Hackney JR, Riley KO Abstract BACKGROUND: Sellar/suprasellar cystic lesions can cause compression of the optic pathways and result in a decline in vision. There have been reports of optic pathways being fenestrated by intracranial aneurysms. This is the first report of a sellar/suprasellar arachnoid cyst causing fenestration of an optic nerve. CASE DESCRIPTION: Our patient presented with an 8 month history of worsening vision. Imaging revealed a sellar/suprase...περισσότερα »

Safe resection of gliomas of the dominant angular gyrus availing of preoperative fMRI and intraoperative DTI.Preliminary series and surgical technique.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Safe resection of gliomas of the dominant angular gyrus availing of preoperative fMRI and intraoperative DTI.Preliminary series and surgical technique.* World Neurosurg. 2015 Nov 5; Authors: D'Andrea G, Familiari P, Di Lauro A, Angelini A, Sessa G Abstract OBJECTIVE: Language dysfunction, visual deficit, numeracy impairment and Gerstmann's syndrome may often occur having approached this cortical area; furthermore, the subcortical white matter is the inviolable limit of "functional neurosurgery". Preoperative functional neuroimaging (fMRI) and tractography are capable of providi... περισσότερα »

Petrous apex cephalocele presenting with cerebrospinal fluid rhinorrhea in an adult.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Petrous apex cephalocele presenting with cerebrospinal fluid rhinorrhea in an adult.* J Clin Neurosci. 2015 Nov 5; Authors: Warade AG, Misra BK Abstract Petrous apex cephalocele (PAC) is a rare condition with very few case reports in the literature. We report a 26-year-old man with cerebrospinal fluid rhinorrhea that was misdiagnosed elsewhere and operated unsuccessfully via the endonasal route. CT cisternography revealed a 3mm right PAC for which he underwent a right subtemporal extradural approach and successful repair. We present what is to our knowledge the first case repo...περισσότερα »

Do obese patients have worse outcomes after direct lateral interbody fusion compared to non-obese patients?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Do obese patients have worse outcomes after direct lateral interbody fusion compared to non-obese patients?* J Clin Neurosci. 2015 Nov 6; Authors: Adogwa O, Farber SH, Fatemi P, Desai R, Elsamadicy A, Cheng J, Bagley C, Gottfried O, Isaacs RE Abstract Obese patients undergoing lumbar spinal fusion surgery are a challenge to the operating surgeon. Direct lateral interbody fusion (DLIF) has been performed for degenerative disease of the lumbar spine with good outcomes; nevertheless, how obese patients fare compared to non-obese patients after DLIF remains unknown. The primary aim...περισσότερα »

A 7666-bp genomic deletion is frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*A 7666-bp genomic deletion is frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations.* Int J Pediatr Otorhinolaryngol. 2015 Oct 23; Authors: Pang X, Chai Y, He L, Chen P, Wang X, Li L, Jia H, Wu H, Yang T Abstract OBJECTIVES: To investigate the genetic cause of the patients with non-syndromic enlarged vestibular aqueduct (EVA) but without bi-allelic SLC26A4 mutations. METHODS: Presence of a homozygous genomic deletion was detected in a Chinese Han deaf patient (D1467-1) who failed to amplify the first three ...περισσότερα »

Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.* Int J Pediatr Otorhinolaryngol. 2015 Oct 30; Authors: Alemi AS, Rosbe KW, Chan DK, Meyer AK Abstract Head and neck lymphatic malformations can create airway management challenges requiring tracheotomy. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), may inhibit growth of lymphatic malformations. We describe two patients born with large lymphatic malformations with improved airway symptoms following sirolimus therapy. Patient #1 underwent tracheotomy and multi-m...περισσότερα »

Hydroxyurea-induced oral ulceration.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Hydroxyurea-induced oral ulceration.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):e232-4 Authors: Badawi M, Almazrooa S, Azher F, Alsayes F Abstract Hydroxyurea is an antimetabolite that is widely used in the treatment of many benign and malignant conditions. This drug is usually well tolerated but has a number of side effects that vary in incidence. In cases of clinically significant adverse events, hydroxyurea is usually discontinued either temporarily or permanently, depending on treatment need versus harm caused by side effects. Here, we report a case of oral...περισσότερα »

Response to letters to the editor.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Response to letters to the editor.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):778-9 Authors: Greene CS, Obrez A PMID: 26548731 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1MxaUX2 via IFTTT

Drs. Greene and Obrez's article inaccurate.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Drs. Greene and Obrez's article inaccurate.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):776 Authors: Cooper BC PMID: 26548730 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1HEEGUq via IFTTT

Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Airway response to sirolimus therapy for the treatment of complex pediatric lymphatic malformations.* Int J Pediatr Otorhinolaryngol. 2015 Oct 30; Authors: Alemi AS, Rosbe KW, Chan DK, Meyer AK Abstract Head and neck lymphatic malformations can create airway management challenges requiring tracheotomy. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), may inhibit growth of lymphatic malformations. We describe two patients born with large lymphatic malformations with improved airway symptoms following sirolimus therapy. Patient #1 underwent tracheotomy and multi-m...περισσότερα »

Infraorbital and infratrochlear nerve blocks combined with general anaesthesia for outpatient rhinoseptoplasty: A prospective randomized, double-blind, placebo-controlled study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Infraorbital and infratrochlear nerve blocks combined with general anaesthesia for outpatient rhinoseptoplasty: A prospective randomized, double-blind, placebo-controlled study.* Anaesth Crit Care Pain Med. 2015 Nov 5; Authors: Boselli E, Bouvet L, Augris-Mathieu C, Bégou G, Diot-Junique N, Rahali N, Vertu-Ciolino D, Gérard C, Pivot C, Disant F, Allaouchiche B Abstract INTRODUCTION: We conducted a study to determine the efficacy of bilateral extraoral infraorbital and infratrochlear nerve blocks during outpatient rhinoseptoplasty under general anaesthesia. PATIENTS AND METHODS: ... περισσότερα »

A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma.* Cancer Treat Rev. 2015 Oct 28; Authors: Zanoletti E, Lovato A, Stritoni P, Martini A, Mazzoni A, Marioni G Abstract Temporal bone squamous cell carcinoma (TBSCC) is an uncommon malignancy with a distinctly poor prognosis in advanced cases. There is still much controversy surrounding the rational diagnostic/therapeutic approach to TBSCC. Diagnostic differences are due mainly to: the small number of cases reported (even in the largest available series); the inappropriate hi... περισσότερα »

Bony regeneration of the sella after transsphenoidal pituitary surgery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Bony regeneration of the sella after transsphenoidal pituitary surgery.* World Neurosurg. 2015 Nov 5; Authors: Yahia-Cherif M, Delpierre I, Hassid S, De Witte O PMID: 26548824 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1MlXrxX via IFTTT

Surgical strategy for complex anterior cerebral artery aneurysms: retrospective case series and literature review.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Surgical strategy for complex anterior cerebral artery aneurysms: retrospective case series and literature review.* World Neurosurg. 2015 Nov 5; Authors: Ota N, Tanikawa R, Miyama M, Matsumoto T, Miyazaki T, Matsukawa H, Yanagisawa T, Suzuki G, Miyata S, Noda K, Tsuboi T, Takeda R, Kamiyama H, Tokuda S Abstract BACKGROUND: Giant, or complex, aneurysms of the anterior cerebral artery (ACA) are rare, but their surgical treatment is important. The authors describe their experiences with bypasses for complex ACA aneurysms and discuss the new classification of ACA bypasses, the conc...περισσότερα »

The Geriatric Scoring System (GSS) for Risk Stratification in Meningioma Patients as a Predictor of Outcome in Patients Treated With Radiosurgery.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*The Geriatric Scoring System (GSS) for Risk Stratification in Meningioma Patients as a Predictor of Outcome in Patients Treated With Radiosurgery.* World Neurosurg. 2015 Nov 5; Authors: Cohen-Inbar O, Lee CC, Schlesinger D, Xu Z, Sheehan JP Abstract INTRODUCTION: Meningiomas are the most common primary benign brain tumor. Radiosurgery (primary or adjuvant) allows excellent local control. The Geriatric scoring system (GSS) for pre-operative risk stratification and outcome prediction of patients with meningiomas has been previously reported. The GSS incorporates eight tumor and pa...περισσότερα »

Surviving the largest atypical parasagittal meningioma in a two-year-old child: a case report and a brief review of the literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*Surviving the largest atypical parasagittal meningioma in a two-year-old child: a case report and a brief review of the literature.* World Neurosurg. 2015 Nov 5; Authors: Li J, Mzimbiri JM, Zhao J, Zhang Z, Liao X, Liu J Abstract BACKGROUND: Meningiomas arising in pediatric populations are rare neoplasms with distinct biological and clinical features. A rare case of a two-year-old boy with extremely large intracranial parasagittal meningioma is presented. To the best of our knowledge, this was the largest parasagittal meningioma to be reported to date in the pediatric age group....περισσότερα »

A singular case of neurosyphilis manifesting through a meningovascular chronic inflammatory process in association with the occurrence of two aneurysms involving the distal A2 segment of both anterior cerebral arteries. A case report and review of literature.

Alexandros G. SfakianakisστοHead and NeckΠριν από 21 ώρες

*A singular case of neurosyphilis manifesting through a meningovascular chronic inflammatory process in association with the occurrence of two aneurysms involving the distal A2 segment of both anterior cerebral arteries. A case report and review of literature.* World Neurosurg. 2015 Nov 5; Authors: Bagatti D, Mazibrada J, Ligarotti GK, Nazzi V, Franzini A PMID: 26548820 [PubMed - as supplied by publisher] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1MlXrht via IFTTT

Targeting ABCB1 and ABCC1 with their specific inhibitor CBT-1 can overcome drug resistance in osteosarcoma.

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 21 ώρες

*Targeting ABCB1 and ABCC1 with their specific inhibitor CBT-1 can overcome drug resistance in osteosarcoma.* Curr Cancer Drug Targets. 2015 Nov 6; Authors: Fanelli M, Hattinger CM, Vella S, Tavanti E, Michelacci F, Gudeman B, Barnett D, Picci P, Serra M Abstract Clinical treatment response achievable with conventional chemotherapy in high-grade osteosarcoma (OS) is severily limited by the presence of intrinsic or acquired drug resistance, which in previous studies has been mainly addressed to overexpression of ABCB1 (MDR1/P-glycoprotein). This study was aimed to estimate the i...περισσότερα »

Development of Linker-conjugated Nanosize Lipid Vesicles: A Strategy for Cell Selective Treatment in Breast Cancer.

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 21 ώρες

*Development of Linker-conjugated Nanosize Lipid Vesicles: A Strategy for Cell Selective Treatment in Breast Cancer.* Curr Cancer Drug Targets. 2015 Nov 6; Authors: Dey NS, Mukherjee B, Maji R, Satapathy BS Abstract Among the various drug delivery devices, nanoliposome is an emerging formulation in the treatment of cancer. Here we developed tamoxifen citrate (TC) loaded nanoliposome conjugated with phosphoethanolamine (PE) by thin film hydration method. Various physicochemical and biopharmaceutical characterization studies such as drug-excipients interaction, surface morphology,...περισσότερα »

Is there a place for bevacizumab in patients with extensive-stage small cell lung cancer?

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 21 ώρες

*Is there a place for bevacizumab in patients with extensive-stage small cell lung cancer?* Curr Cancer Drug Targets. 2015 Nov 6; Authors: Roviello G, Generali D Abstract It was estimated that small cell lung cancer (SCLC) concerns about 15% of all lung cancer cases. Patients with SCLC are usually diagnosed in advanced stage of disease. Unfortunately at this stage, prognosis is very poor. Bevacizumab is a monoclonal antibody against VEGF, which inhibits the angiogenesis in malignant tumors. Although Bevacizumab has been approved for first-line use in advanced non-SCLC, the first... περισσότερα »

Cone beam computed tomography (CBCT) sialography-an adjunct to salivary gland ultrasonography in the evaluation of recurrent salivary gland swelling.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Cone beam computed tomography (CBCT) sialography-an adjunct to salivary gland ultrasonography in the evaluation of recurrent salivary gland swelling.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):771-5 Authors: Kroll T, May A, Wittekindt C, Kähling C, Sharma SJ, Howaldt HP, Klussmann JP, Streckbein P Abstract OBJECTIVE: Cone beam computed tomography (CBCT) sialography could help improve the visualization of the ductal system of salivary glands. The aim of this retrospective investigation was to monitor the use of CBCT sialography for the diagnosis of pathologies ...περισσότερα »

Three-dimensional evaluation of human jaw bone microarchitecture: correlation between the microarchitectural parameters of cone beam computed tomography and micro-computer tomography.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Three-dimensional evaluation of human jaw bone microarchitecture: correlation between the microarchitectural parameters of cone beam computed tomography and micro-computer tomography.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):762-70 Authors: Kim JE, Yi WJ, Heo MS, Lee SS, Choi SC, Huh KH Abstract OBJECTIVE: To evaluate the potential feasibility of cone beam computed tomography (CBCT) in the assessment of trabecular bone microarchitecture. STUDY DESIGN: Sixty-eight specimens from four pairs of human jaw were scanned using both micro-computed tomography (micro-CT... περισσότερα »

Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):751-760.e2 Authors: Sato J, Ohuchi M, Wada M, Ohga N, Asaka T, Yoshikawa K, Miyakoshi M, Hata H, Satoh A, Kitagawa Y Abstract OBJECTIVE: Sequential postoperative salivary interleukin-6 (IL-6) concentrations were examined in patients with oral squamous cell carcinoma (OSCC) who had early or late locoregional recurrences or those who ...περισσότερα »

Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 21 ώρες

*Topical lipophilic epigallocatechin-3-gallate on herpes labialis: a phase II clinical trial of AverTeaX formula.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):717-24 Authors: Zhao M, Zheng R, Jiang J, Dickinson D, Fu B, Chu TC, Lee LH, Pearl H, Hsu S Abstract OBJECTIVE: Previous in vitro and in vivo studies indicated that catechins from the tea plant (Camellia sinensis) have a therapeutic effect on herpes simplex virus infections. The aim of this study was to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX, Camellix... περισσότερα »

Structure and function of the septum nasi and the underlying tension chord in crocodylians

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 22 ώρες

Abstract A long rostrum has distinct advantages for prey capture in an aquatic or semi-aquatic environment but at the same time poses severe problems concerning stability during biting. We here investigate the role of the septum nasi of brevirostrine crocodilians for load-absorption during mastication. Histologically, both the septum nasi and the septum interorbitale consist of hyaline cartilage and therefore mainly resist compression. However, we identified a strand of tissue extending longitudinally below the septum nasi that is characterized by a high content of collagenous and... περισσότερα »

A reappraisal of Cerebavis cenomanica (Aves, Ornithurae), from Melovatka, Russia

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 22 ώρες

Abstract The evolution of the avian brain is of crucial importance to studies of the transition from non-avian dinosaurs to modern birds, but very few avian fossils provide information on brain morphological development during the Mesozoic. An isolated specimen from the Cenomanian of Melovatka in Russia was described by Kurochkin and others as a fossilized brain, designated the holotype of *Cerebavis cenomanica* Kurochkin and Saveliev and tentatively referred to Enantiornithes. We have previously highlighted that this specimen is an incomplete skull, rendering the diagnostic charac... περισσότερα »

Regulation of connexin signaling by the epigenetic machinery

Alexandros G. SfakianakisστοEvolution of a geneΠριν από 22 ώρες

Publication date: Available online 10 November 2015 *Source:*Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Author(s): Mathieu Vinken Connexins and their channels are involved in the control of all aspects of the cellular life cycle, ranging from cell growth to cell death, by mediating extracellular, intercellular and intracellular communication. These multifaceted aspects of connexin-related cellular signaling obviously require strict regulation. While connexin channel activity is mainly directed by posttranslational modifications, connexin expression as such is m... περισσότερα »

Endocrine Pathology Society Hubert Wolfe Award for 2015: Call for Nominations

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 ώρες

from Cancer via ola Kala on Inoreader http://ift.tt/1RKAp7A via IFTTT

CPR by medics: Keep pumping or stop for rescue breathing?

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 22 ώρες

UW Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRlQM via IFTTT

Finding a way to cope: A qualitative study of the experiences of persons with spinal cord injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 22 ώρες

Journal of Neuroscience Nursing from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRpA0 via IFTTT

Head to head trial challenges AAP guidelines for treating bronchiolitis

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 22 ώρες

Montefiore Medical Center News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1kIRlk2 via IFTTT

Sensors, Vol. 15, Pages 28271-28286: Real-Valued Covariance Vector Sparsity-Inducing DOA Estimation for Monostatic MIMO Radar

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

In this paper, a real-valued covariance vector sparsity-inducing method for direction of arrival (DOA) estimation is proposed in monostatic multiple-input multiple-output (MIMO) radar. Exploiting the special configuration of monostatic MIMO radar, low-dimensional real-valued received data can be obtained by using the reduced-dimensional transformation and unitary transformation technique. Then, based on the Khatri–Rao product, a real-valued sparse representation framework of the covariance vector is formulated to estimate DOA. Compared to the existing sparsity-inducing DOA estimat... περισσότερα »

Remote Sensing, Vol. 7, Pages 14988-15013: A Comparative Study of Sampling Analysis in the Scene Classification of Optical High-Spatial Resolution Remote Sensing Imagery

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Scene classification, which consists of assigning images with semantic labels by exploiting the local spatial arrangements and structural patterns inside tiled regions, is a key problem in the automatic interpretation of optical high-spatial resolution remote sensing imagery. Many state-of-the-art methods, e.g., the bag-of-visual-words model and its variants, the topic models and unsupervised feature learning-based approaches, share similar procedures: patch sampling, feature learning and classification. Patch sampling is the first and a key procedure, and it has a considerable in... περισσότερα »

A qualitative evidence synthesis on the management of male obesity

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

BMJ Open from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5UXj via IFTTT

Adherence to competing strategies for colorectal cancer screening over 3 years

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

The American Journal of Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6krP via IFTTT

Lateral approach liver hanging maneuver in laparoscopic anatomical liver resections

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Surgical Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6hMR via IFTTT

Meta-analysis of laparoscopic surgery for recurrent Crohn’s disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Surgery Today from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5U9L via IFTTT

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Antiviral Research from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5S1y via IFTTT

Angiogenesis and vascular endothelial growth factor-a expression associated with inflammation in pediatric Crohn's disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Journal of Gastrointestinal Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5U9E via IFTTT

Dexmedetomidine versus morphine infusion following laparoscopic bariatric surgery: effect on supplemental narcotic requirement during the first 24 h

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Surgical Endoscopy from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5U9z via IFTTT

Tripterygium wilfordii hook F as maintenance treatment for Crohn's disease

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

The American Journal of the Medical Sciences from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6hfI via IFTTT

Variation in treatment priorities for chronic hepatitis c: a latent class analysis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

The Patient - Patient-Centered Outcomes Research from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5TCK via IFTTT

Randomized comparison of surveillance intervals in familial colorectal cancer

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Journal of Clinical Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6hwc via IFTTT

Positive regulation of β-catenin–PROX1 signaling axis by DBC1 in colon cancer progression

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Oncogene from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6hw8 via IFTTT

Prognostic factors for progression-free and overall survival in advanced biliary tract cancer

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Annals of Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6eAF via IFTTT

Prospective cohort study comparing transient EUS guided elastography to EUS-FNA for the diagnosis of solid pancreatic mass lesions

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Pancreatology from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6gZ9 via IFTTT

Palliative chemotherapy for patients 70 years of age and older with metastatic colorectal cancer: A single-centre experience

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Current Oncology from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6gIT via IFTTT

Influence of the intervention of exercise on obese type II diabetes mellitus: A meta-analysis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Primary Care Diabetes from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6gIP via IFTTT

Characteristics of colonoscopic findings in the very elderly

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Geriatrics and Gerontology International from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5QGT via IFTTT

Changes in insulin sensitivity and secretion after sleeve gastrectomy

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

British Journal of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5T5M via IFTTT

Prevalence of pathogenic mutations in cancer predisposition genes among pancreatic cancer patients

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Cancer Epidemiology, Biomarkers & Prevention from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5Qqv via IFTTT

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the “magic bullet” to kill cccDNA

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Antiviral Research from #Medicine via ola Kala on Inoreader http://ift.tt/1Sf5Qqm via IFTTT

Blunting of colon contractions in diabetics with gastroparesis quantified by wireless motility capsule methods

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

PLOS ONE from #Medicine via ola Kala on Inoreader http://ift.tt/1Mx6e3r via IFTTT

Family physicians’ intention to support women in making informed decisions about breast cancer screening with mammography: a cross-sectional survey

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 ώρες

Background: The net benefits of routine breast cancer screening with mammography have been questioned, and there is evidence to indicate that supporting women to make an informed decision about breast cancer screening with mammography is preferable. The aims of this study were to assess the intention of family physicians to provide women with this support and the determinants of this intention, and to identify factors that might influence family physicians adopting this behavior. Methods: Family physicians from the province of Quebec, Canada, attending a 45-min lecture on informed...περισσότερα »