Baicalein in Cancer-Induced Bone Pain
The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain: Cancer-induced bone pain (CIBP) is a severe type of chronic pain. It is imperative to explore safe and effective analgesic drugs for CIBP treatment. Baicalein (BE), isolated from the traditional Chinese herbal medicine Scutellaria baicalensis Georgi (or Huang Qin), has been demonstrated to have anti-inflammatory and neuroprotective effects. In this study, we examined the effect of BE on CIBP and the mechanism of this effect. Intrathecal and oral administration of BE at different doses could alle... περισσότερα »
Ordinary and Activated Bone Grafts
Ordinary and Activated Bone Grafts: Applied Classification and the Main Features: Bone grafts are medical devices that are in high demand in clinical practice for substitution of bone defects and recovery of atrophic bone regions. Based on the analysis of the modern groups of bone grafts, the particularities of their composition, the mechanisms of their biological effects, and their therapeutic indications, applicable classification was proposed that separates the bone substitutes into “ordinary” and “activated.” The main differential criterion is the presence of biologically active... περισσότερα »
Stem Cell-Based Therapeutics to Improve Wound Healing
Stem Cell-Based Therapeutics to Improve Wound Healing: Issues surrounding wound healing have garnered deep scientific interest as well as booming financial markets invested in novel wound therapies. Much progress has been made in the field, but it is unsurprising to find that recent successes reveal new challenges to be addressed. With regard to wound healing, large tissue deficits, recalcitrant wounds, and pathological scar formation remain but a few of our most pressing challenges. Stem cell-based therapies have been heralded as a promising means by which to surpass current limita... περισσότερα »
Laryngeal Paraganglioma in a Patient with Carotid Body Paraganglioma
An Unusual Case of Laryngeal Paraganglioma in a Patient with Carotid Body Paraganglioma: Multimodality Imaging Findings: Multiple paragangliomas of the head and neck are rare conditions. Carotid paragangliomas are most common multiple paragangliomas. Laryngeal paragangliomas are very rare neuroendocrine tumors and usually are seen as symptomatic solitary lesions. We present multimodality imaging findings of incidentally detected laryngeal paraganglioma in a woman with synchronous carotid body paraganglioma and positive family history. To the best of our knowledge, this is the first ... περισσότερα »
Moxifloxacin-Induced Hypoglycemia
HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia: The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry. The whole-cell patch clamp method was used to examine the effect of moxifloxacin on HERG channel currents. A glucose tolerance test was used to analyze the effects of moxifloxacin on blood glucose and insulin concentrations in mice. Results show that HERG protein was expressed in human pancreatic β-cells. Moxifloxacin inhibited HERG time-depe... περισσότερα »
Ceruminous Adenoma of the External Auditory Canal: A Case Report with Imaging and Pathologic Findings
Ceruminous Adenoma of the External Auditory Canal: A Case Report with Imaging and Pathologic Findings: Ceruminous adenomas are benign tumors that are rare in humans and present with a nonspecific symptomatology. The treatment of choice is surgical excision. We present an 87-year-old woman who presented with a reddish, tender, round, soft mass of the outer third of the inferior wall of the left external auditory canal, discharging a yellowish fluid upon pressure. Coincidentally, due to her poor general condition, this patient also showed symptoms consistent with chronic otitis media,... περισσότερα »
Biomechanical Evaluation of a Mandibular Spanning Plate Technique Compared to Standard Plating Techniques to Treat Mandibular Symphyseal Fractures
Biomechanical Evaluation of a Mandibular Spanning Plate Technique Compared to Standard Plating Techniques to Treat Mandibular Symphyseal Fractures: Purpose. The purpose of this study is to compare the biomechanical behavior of the spanning reconstruction plate compared to standard plating techniques for mandibular symphyseal fractures. Materials and Methods. Twenty-five human mandible replicas were used. Five unaltered synthetic mandibles were used as controls. Four experimental groups of different reconstruction techniques with five in each group were tested. Each synthetic mandibl...περισσότερα »
Nodular melanoma versus superficial spreading melanoma
An assessment of clinical pathways and missed opportunities for the diagnosis of nodular melanoma versus superficial spreading melanoma: Abstract Background Missed opportunities in the diagnosis of nodular melanoma (NM) carry high prognostic penalties due to the rapid rate of NM growth. To date, an assessment of the pathways to diagnosis of NM versus superficial spreading melanoma (SSM) specifically comparing numbers of opportunities missed to undertake biopsy has not been performed. Methods A retrospective questionnaire of 120 patients (60 NM patients, age and sex matched to 60 SSM...περισσότερα »
The contribution of outdoor particulate matter (PM1, PM2.5, PM10) to school indoor environment
The contribution of outdoor particulate matter (PM1, PM2.5, PM10) to school indoor environment: The contributions of outdoor and indoor sources to the indoor concentrations of particulate matter (PM1, PM2.5, and PM10) were investigated in a secondary school in Wroclaw, Poland. PM measurements were performed one week per month from December 2009 to October 2010. The sizes of the aerosols generated form indoor sources were in the range of 1–2.5 µm in winter and 2.5–10 µm in summer. It was found that the indoor PM1 concentrations in the school were mostly due to infiltration, with an ...περισσότερα »
Cerebral imaging in infectious endocarditis: A clinical study
10.3109/23744235.2015.1109704<br>Julia Champey from Infection via ola Kala on Inoreader http://ift.tt/1PvsyNw via IFTTT
No increased risk of acute kidney injury after a single dose of gentamicin in patients with sepsis
10.3109/23744235.2015.1109136<br>Maarten Cobussen from Infection via ola Kala on Inoreader http://ift.tt/1PvswVT via IFTTT
A long-term survey of brucellosis: Is there any marker to predict the complicated cases?
10.3109/23744235.2015.1107187<br>Bircan Kayaaslan from Infection via ola Kala on Inoreader http://ift.tt/1RYvmR6 via IFTTT
Dental Injury Models: Experimental Tools for Understanding Neuroinflammatory Interactions and Polymodal Nociceptor Functions
Dental Injury Models: Experimental Tools for Understanding Neuroinflammatory Interactions and Polymodal Nociceptor Functions: 1. M.R. Byers 1. Departments of Anesthesiology, Biological Structure, and Endodontics, Box 356540, University of Washington, Seattle, Washington 98195-6540 1. M.V.O. Narhi 1. Institute of Dentistry, University of Turku, 20520, Turku, Finland, Department of Physiology, University of Kuopio, 70211, Kuopio Abstract Recent research has shown that peripheral mechanisms of pain are much more complex than previously thought, and they diffe... περισσότερα »
Airborne chemical pollutants in domestic environments in Europe
Integrated exposure for risk assessment in indoor environments based on a review of concentration data on airborne chemical pollutants in domestic environments in Europe: This review set out to identify data sets for airborne chemical pollutants measured in domestic dwellings within European Union (EU) countries from the literature published during 1995–2010. A total of 74 papers satisfied inclusion criteria, and from those papers data on country location, population sampled, sampling period, number of samples and summary statistics of concentrations measured were gathered. The che...περισσότερα »
When and how should patients with multiple endocrine neoplasia type 1 be screened for thymic and bronchial carcinoid tumors?
Clinical Question: When and how should patients with multiple endocrine neoplasia type 1 be screened for thymic and bronchial carcinoid tumors?: Summary Patients with multiple endocrine neoplasia type 1 (MEN1) are commonly evaluated for clinical manifestations of this syndrome with the rationale that early diagnosis and adequate treatment will result in improved survival and quality of life. Thymic and bronchial carcinoid tumors are uncommon but important manifestation of MEN1. Current practice guidelines recommend evaluation with computed tomography or magnetic resonance imaging s...περισσότερα »
Diagnostic accuracy of thyroid nodule growth to predict malignancy in thyroid nodules with benign cytology: Systematic review and meta-analysis
Diagnostic accuracy of thyroid nodule growth to predict malignancy in thyroid nodules with benign cytology: Systematic review and meta-analysis: Abstract Background Thyroid ultrasound to assess for nodular growth is commonly performed during the follow-up of patients with benign thyroid nodules, with the goal of identifying patients with a missed diagnosis of thyroid cancer. The objective of this study was to summarise the evidence regarding the diagnostic accuracy of growth during follow-up of benign thyroid nodules for thyroid cancer. Methods We searched multiple electronic databa...περισσότερα »
Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells
Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells: • LGX818 exhibits anti-proliferative activity in BRAFV600E melanoma cells.• GSK3β does not contribute to LGX818-triggerd turnover of CyclinD1.• LGX818 induces senescence rather than apoptosis in BRAFV600E melanoma cells.• LGX818 triggers autophagy by inhibiting the mTOR pathway in BRAFV600E melanoma cells.• Autophagy plays a role in LGX818-induced senescence.
p53 protein in human esophageal squamous cancer cells
MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background via Cancer Letters Publication date: 28 January 2016 *Source:*Cancer Letters, Volume 370, Issue 2 Author(s): Zhimin Ye, Jun Fang, Shujun Dai, Yuezhen Wang, Zhenfu Fu, Wei Feng, Qichun Wei, Pintong Huang MiR-34a has been reported as a non-coding RNA universally expressed in normal old cells and a probable suppressor of diverse cancer cells; however, this miRNA's expression and anti-tumor mechanism i... περισσότερα »
IFIT2-depleted metastatic oral squamous cell carcinoma cells
Blocking TNF-α inhibits angiogenesis and growth of via Cancer Letters Publication date: 28 January 2016 *Source:*Cancer Letters, Volume 370, Issue 2 Author(s): Kuo-Chu Lai, Chung-Ji Liu, Tsung-Jen Lin, Ai-Chung Mar, Hsiu-Hua Wang, Chi-Wei Chen, Zi-Xuan Hong, Te-Chang Lee Our previous study demonstrated that the depletion of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) promoted metastasis and was associated with a poor prognosis in patients with oral squamous cell carcinoma (OSCC). Our current study explores the major downstream signaling involved in IFIT2 deplet...περισσότερα »
Relationship between morphological characteristics of hyoid bone and mandible
Relationship between morphological characteristics of hyoid bone and mandible in Japanese cadavers using three-dimensional computed tomography: AbstractThe aim of this study is to obtain a quantitative anatomical description of the hyoid bone and mandible using three-dimensional computed tomography. Hyoid bones were obtained from a total of 101 cadavers varying in age from 67 to 102 years. The percentage of symmetrical U-type and asymmetrical-type hyoid bones was low compared with symmetrical V type (14.9, 15.8, and 69.3 %, respectively), and no significant sex difference was obser... περισσότερα »
Development of a new system for guidewire-assisted tracheal intubation
Development of a new system for guidewire-assisted tracheal intubation: manikin and cadaver evaluation: Summary Guided intubation using a tracheal tube and semi-rigid introducer is associated with technical difficulties, failure and traumatic complications. We describe the development of a new system of guidewire-assisted tracheal intubation that may circumvent these problems. A reinforced silicone tracheal tube was modified with a guide channel built inside its wall, and a nitinol non-kinking guidewire was matched to this channel. Both anterograde and retrograde tracheal intubatio... περισσότερα »
Paracetamol pharmacokinetics and metabolism in young women
Paracetamol pharmacokinetics and metabolism in young women: Background: There is relevant between individual variability in paracetamol clearance in young women. In this pooled study, we focused on the population pharmacokinetic profile of intravenous paracetamol metabolism and its covariates in young women. Methods: Population PK parameters using non-linear mixed effect modelling were estimated in a pooled dataset of plasma and urine PK studies in 69 young women [47 at delivery, 8/47 again 10–15 weeks after delivery (early postpartum), and 7/8 again 1 year after delivery (late postpa... περισσότερα »
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies: Cancer onset and progression have been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation and therefore antioxidant agents could interfere with carcinogenesis. It is well known that conventional radio-/chemotherapies influence tumour outcome through ROS modulation. Since these antitumour treatments have important side effects, the challenge is to develop new anticancer therapeutic strategies more effective and less toxic f...περισσότερα »
Oncolytic viral therapy for neuroblastoma cells with Sindbis virus AR339 strain
Oncolytic viral therapy for neuroblastoma cells with Sindbis virus AR339 strain: Abstract PurposeWith current treatment regimens, high-risk neuroblastoma (NB) remains largely incurable. Oncolytic viral therapy uses replication-competent viruses, like *Sindbis virus* (SINV), to kill cancers. The SINV AR339 strain is blood borne and relatively non-virulent. We evaluated the feasibility of SINV AR339 for treating human NB. MethodsThe cytotoxicity and viral growth of SINV AR339 were evaluated for five human NB cell lines, SK-N-SH, IMR-32, LAN-5, GOTO, and RT-BM-1. SINV-induced apo...περισσότερα »
Robotic surgery in children: adopt now, await, or dismiss?
Robotic surgery in children: adopt now, await, or dismiss?: AbstractThe role of robot-assisted surgery in children remains controversial. This article aims to distil this debate into an evidence informed decision-making taxonomy; to adopt this technology (1) now, (2) later, or (3) not at all. Robot-assistance is safe, feasible and effective in selected cases as an adjunctive tool to enhance capabilities of minimally invasive surgery, as it is known today. At present, expectations of rigid multi-arm robotic systems to deliver higher quality care are over-estimated and poorly substan... περισσότερα »
Anaesthesia-associated hypersensitivity reactions
Anaesthesia-associated hypersensitivity reactions: seven years' data from a British bi-specialty clinic: Summary Our bi-specialty clinic was established to systematically investigate patients with suspected peri-operative hypersensitivity reactions. Four hundred and ten patients were studied; 316 following an intra-operative reaction (‘postoperative’ group) and 94 with a previous history of reaction, referred before undergoing anaesthesia (‘pre-operative’ group). In the postoperative group, 173 (54.7%) were diagnosed with IgE-mediated reactions: 65 (37.6%) to neuromuscular blocking... περισσότερα »
Bioavailability Study of an Innovative Orobuccal Formulation of Glutathione
Bioavailability Study of an Innovative Orobuccal Formulation of Glutathione: Alteration of the ubiquitous thiol tripeptide glutathione (GSH) is involved in oxidative stress, which plays a role in ageing; consequently, GSH is closely related to this process characterized by progressive decline in the efficiency of physiological function and increased susceptibility to disease. When circulating GSH decreases, oral administration might be considered a therapeutic benefit. Unfortunately, due to the hydrolysis of the tripeptide by intestinal -glutamyltransferase, dietary glutathione is n... περισσότερα »
In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens
In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens: *Serratia marcescens* is a common pathogenic bacterium which can cause infections both in human and animals. It can cause a range of diseases, from slight wound infections to life-threatened bacteraemia and pneumonia. The emergence of antimicrobial resistance has limited the treatment caused by the bacterium to a great extent. Consequently, there is an urgent need in developing novel antimicrobial strategies against this pathogen. Synergistic strategy is a new approach against t...περισσότερα »
Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells
Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells: Improvement in the expansion method of adult stem cells may augment their use in regenerative therapy. Using human dermal papilla cell line as well as primary dermal papilla cells as model systems, the present study demonstrated that ciprofloxacin treatment could prevent the loss of stemness during culture. Clonogenicity and stem cell markers of dermal papilla cells were shown to gradually decrease in the culture in a time-dependent manner. Treatment of the cells with nontoxic concentrations of ciprofloxacin could ma... περισσότερα »
Analysis of persistence of human papillomavirus infection in men evaluated by sampling multiple genital sites
Analysis of persistence of human papillomavirus infection in men evaluated by sampling multiple genital sites: *OBJECTIVE:* Although human papillomavirus (HPV) infection has been studied extensively in women, data on male infection are limited. The purpose of this study was to investigate persistence of HPV infection at multiple genital sites in men and to define potential associations with socio-behavioural characteristics. *PATIENTS AND METHODS:* Penile, urethral and seminal specimens were tested by the INNO-LiPA HPV system (Innogenetics) and a PCR assay. Persistence was defined... περισσότερα »
An extracellular matrixcculture system for induced pluripotent stem cells derived from human dental pulp cells
An extracellular matrixcculture system for induced pluripotent stem cells derived from human dental pulp cells: *OBJECTIVE:* Induced pluripotent stem cells (iPSCs) have emerged as a promising tool for treating incurable diseases. The current challenges are to avoid potential xenopathogenic transmission and immune rejection potentially caused by exposure of iPSCs to animal-derived products. In addition, an efficient feeder cell-free culture condition will be required for minimizing batch-to-batch variation and facilitating scale-up. Therefore, establishing an efficient extracellular... περισσότερα »
Detection of palisade vessels as a landmark for Barrett’s esophagus
Detection of palisade vessels as a landmark for Barrett’s esophagus in a Western population: Abstract BackgroundIn Japan, palisade vessels (PV) are used to distinguish the esophagogastric junction (EGJ). Elsewhere, the EGJ is defined by the upper end of the gastric folds (GF) and PV are considered difficult to detect. This study evaluated the detection rate of PV in Western patients with Barrett’s esophagus (BE) using white light imaging (WLI) and narrow band imaging (NBI), and quantified any discordance between Western and Japanese criteria for the EGJ. MethodsIn 25 BE patien... περισσότερα »
Results of Surgical Therapy in Patients with Medullary Thyroid Carcinoma
Results of Surgical Therapy in Patients with Medullary Thyroid Carcinoma: AbstractMedullary thyroid carcinoma (MTC) is a rare form of malignancy, having an intermediate prognosis. Controversies exist regarding the best surgical approach. The aim of the study was to analyze the outcome in a group of patients with MTC, diagnosed and followed up in a single care center. We performed a retrospective analysis of all the patients diagnosed with MTC in the Department of Endocrinology from the County Emergency Hospital Timisoara between 1992 and 2012. The study group included 19 patients, ...περισσότερα »
Extraosseous Ewing Sarcoma: Diagnosis, Prognosis and Optimal Management
Extraosseous Ewing Sarcoma: Diagnosis, Prognosis and Optimal Management: AbstractExtraosseous Ewing sarcomas (EESs) are rare tumours originating from soft tissues. Their clinical picture depends mainly on the primary site of the sarcoma. Patient characteristics and outcomes seem to be different in EES compared to patients with skeletal Ewing sarcoma, with implications for patient care and prognosis. However, multimodality therapeutic strategies are recommended for all types of the Ewing tumour family. The available diagnostic tools include ultrasonographic evaluation and computed t...περισσότερα »
Acute benign vertebral compression fractures: “see-through sign” on contrast-enhanced MR images
Acute benign vertebral compression fractures: “see-through sign” on contrast-enhanced MR images: Abstract PurposeTo retrospectively evaluate the diagnostic role of the contrast-enhanced MRI (CE-MRI) for differentiation between benign VCFs and malignant VCFs focusing on the internal transparent trabecular bone on CE-MRI (the “see-through sign”). Materials and methodsThe institutional review board approved this study and informed consent was waived due to the retrospective nature of the study. From January 2012 to December 2013, all 149 consecutive benign or malignant VCF patien... περισσότερα »
Simpson grade II removal (coagulation of the dural attachment after gross total removal) of spinal meningioma
Long-term recurrence rates after the removal of spinal meningiomas in relation to Simpson grades: Abstract PurposeSimpson grade II removal (coagulation of the dural attachment after gross total removal) of spinal meningioma is considered an acceptable alternative, but increased recurrence after more than 10 years has been reported. More attention must be paid to the long-term surgical outcomes after Simpson grade II removal. MethodsA retrospective review was performed for 20 patients (M:F = 5:15; age, 59 ± 9 years) with Simpson grade II removal (mean follow-up period, 12.9 yea...περισσότερα »
C6 mesenchymal chondrosarcoma
Cervical subtotal en-bloc spondylectomy of C6 mesenchymal chondrosarcoma: Abstract IntroductionWe present a case of C6 mesenchymal chondrosarcoma and discuss safe posterior to anterior approach subtotal en-bloc spondylectomy. Materials and methodsA 29-year-old male consulted for our department with severe posterior neck pain doing exercise. CT scan demonstrated a primary osteolytic lesion on C6 left transverse foramen and MRI demonstrated the tumor involved C6 vertebra from layers B, C and F sectors 4–6 encasing left vertebral artery. Preoperatively neurointerventional radiolo... περισσότερα »
Extension type fracture of the ankylotic thoracic spine with gross displacement causing esophageal rupture
Extension type fracture of the ankylotic thoracic spine with gross displacement causing esophageal rupture: Abstract PurposeThis study aimed at discussing the relevance of the type B3 fracture of the new AOSpine classification. MethodsHyperextension fractures of the spine are rare in the general population, but common in the ankylotic spine. We present a case of a severe spinal fracture with concomitant esophageal rupture, which was diagnosed early and could be treated during the initial trauma care. ResultsThe spinal column was stabilized using a percutaneous technique aft...περισσότερα »
Full-Thickness-Resection-Device (FTRD)
Full-Thickness-Resection-Device (FTRD): Zusammenfassung HintergrundEine Vollwandresektion im Kolon und Rektum ist einer endoskopischen Submukosadissektion (ESD) im Hinblick auf Kuration, En-bloc-Resektion und R0-Status überlegen. Das Full-Thickness-Device (FTRD, Ovesco, Germany) ist das erste kommerziell erhältliche endoskopische System, das eine peritoneale Verschlusstechnik mit nachfolgender Vollwandresektion in einem Schritt realisiert. ZielIn dieser Studie wurde das FTRD in Bezug auf die Effektivität einer histologisch nachgewiesenen Vollwandresektion, den R0-Status und die... περισσότερα »
Risikobewusstsein und Training zur Prävention von Komplikationen in der minimal-invasiven Chirurgie
Risikobewusstsein und Training zur Prävention von Komplikationen in der minimal-invasiven Chirurgie: Zusammenfassung HintergrundDie minimal-invasive Chirurgie (MIC) fordert vom Chirurgen im Vergleich zur offenen Chirurgie zusätzliches Geschick und Fähigkeiten. Die indirekte Kamerasicht, fehlende dreidimensionale Sicht, mangelndes Gewebegefühl sowie die schwierige Instrumentenkoordination mit Drehpunkt- und Hebeleffekt führen zu einer verlängerten Lernkurve. Das resultierende höhere Risiko zur Entstehung von Komplikationen bedingt ein spezielles Risikobewusstsein. Ein Training der ... περισσότερα »
Die spezifischen Komplikationsrisiken der minimal-invasiven Chirurgie
Die spezifischen Komplikationsrisiken der minimal-invasiven Chirurgie: ZusammenfassungBei Lagerung, Zugang und Instrumentation unterscheidet sich die minimal-invasive Chirurgie (MIC) fundamental von der konventionell-offenen Chirurgie. Jeder dieser Aspekte ist mit einer eigenen, spezifischen Morbidität assoziiert, wie z. B. Lagerungsschäden, Trokarverletzungen, Hyperkapnie und thermische Läsionen. Technologische Entwicklungen und zunehmende Erfahrung erklären die Reduktion von MIC-assoziierten Komplikationen und das Meistern von besonderen Herausforderungen. Diese Fortschritte sind... περισσότερα »
Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy
Guidelines for treatment of immune-mediated cerebellar ataxias: AbstractImmune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy. Despite the identification of an increasing number of immune-mediated cerebellar ataxias, there is no proposed standardized therapy. We evaluated the efficacies of immunotherapies in reported cases using a common scale of daily activity. The analysis highlighted the importance of removal of autoimmune triggering factors (e.g., gluten or canc...περισσότερα »
The Importance of Frequency Regions for Cochlear Implant Patients
The Importance of Frequency Regions for Cochlear Implant Patients: Sladen and Ricketts (2015) report that given current cochlear implant (CI) technology, the majority of post-lingually deafened adults achieve 80 percent word recognition (in quiet) after only six months experience with a CI. In their study, CI users were presented with monaural information and the NH listeners had binaural input. The noisy condition was a 10 dB SNR with six-talker babble. Of note, “the average decrease in performance between quiet and noisy conditions was 13% for the NH group and 20 percent for the ... περισσότερα »
The Relationship between Mother-Daughter Self-Objectification: Identifying Direct, Indirect, and Conditional Direct Effects
The Relationship between Mother-Daughter Self-Objectification: Identifying Direct, Indirect, and Conditional Direct Effects: AbstractGrounded in aspects of objectification theory, social learning theory, and attachment theory, we investigated the extent to which mothers’ and daughters’ self-objectification were related to one another’s and also identified three potential intervening factors. Specifically, we hypothesized a (statistical) direct effect of mothers’ self-objectification on that of their daughters’ (H1), as well as investigated a conditional direct effect (i.e., materna... περισσότερα »
Hemagglutinin protease secreted by V. cholerae induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses tumor growth in mice model
Hemagglutinin protease secreted by V. cholerae induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses tumor growth in mice model: AbstractConventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for cancer treatment. In this study we have shown antitumor activity of hemagglutinin protease (HAP) secreted by *Vibrio cholerae.* One µg of HAP showed potent ant... περισσότερα »
Cancer stem cells targeting agents
Cancer stem cells targeting agents – a review: Major current cancer strategies like surgery, radiotherapy, and chemotherapy are compromised due to major problem of recurrence, which usually lead to mortality. The widely accepted reason for this is resistance offered by cancer cells towards cancer drugs or inability of a therapeutic procedure to target real culprits viz. cancer-initiating cells (cancer stem cells). So, there is a current need of development of new agents targeting these cancer stem cells in order to overcome resistance to therapeutic procedures. The present review ... περισσότερα »
Orthostatic intolerance in women with vasovagal syncope
Reduced venous compliance - an important determinant for orthostatic intolerance in women with vasovagal syncope: The influence of lower limb venous compliance on orthostatic vasovagal syncope is uncertain. The most widespread technique to calculate venous compliance uses a non-physiological quadratic regression equation. The aim was therefore to construct a physiologically derived venous wall model for calculation of calf venous compliance, and to determine the effect of venous compliance on tolerance to maximal lower body negative pressure (LBNP). Venous occlusion plethysmography...περισσότερα »
Adénome parathyroïdien oncocytaire
Adénome parathyroïdien oncocytaire via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): A. Paul, A. Villepelet, M. Lefèvre, S. Périé IntroductionL’analyse cytologique d’un nodule thyroïdien retrouve fréquemment la présence de cellules oncocytaires (ou cellules de Hürthle) dans les néoplasmes folliculaires, dont seule l’analyse histologique définitive permet de caractériser son potenti... περισσότερα »
Le lambeau supraclaviculaire dans les reconstructions de la face et du cou
Le lambeau supraclaviculaire dans les reconstructions de la face et du cou via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): S. Atallah, A. Guth, F. Chabolle, C.-A. Bach L’anatomie complexe de la tête et du cou nécessite de posséder un large éventail de lambeaux pédiculés ou libres afin d’assurer une reconstruction optimale des différentes pertes de substances secondaires au traitem... περισσότερα »
Diagnostic des récidives locales et des localisations métachrones en cancérologie des voies aérodigestives supérieures
Recommandations de la SFORL (version courte). via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): C. Halimi, B. Barry, D. De Raucourt, O. Choussy, B. Dessard-Diana, S. Hans, D. Lafarge La surveillance est essentielle dans la prise en charge des patients atteints de cancers des voies aérodigestives supérieures. Ces recommandations de la SFORL ont été établies par un groupe d’experts ...περισσότερα »
Les lavages de nez
: de l’empirisme à la médecine par les preuves. Revue de la littérature via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): P.-L. Bastier, A. Lechot, L. Bordenave, M. Durand, L. de Gabory Les lavages de nez ont un rôle non négligeable pour le traitement de nombreuses pathologies rhinosinusiennes et lors des soins postopératoires. Cependant, il existe une très grande hétérogénéité de ...περισσότερα »
Étude de l’expression du KI67 et du CD10 comme facteurs prédictifs de récidive de l’améloblastome
Étude de l’expression du KI67 et du CD10 comme facteurs prédictifs de récidive de l’améloblastome via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): A. Blel, W. Ajouli, A. Landoulsi, N. Zneidi, A. Arfaoui, F. Faten IntroductionL’améloblastome est une tumeur odontogène bénigne, rare, purement épithéliale, caractérisée par un potentiel élevé d’invasion locale et de récidive.ButÉtudier...περισσότερα »
Les lymphomes non hodgkiniens extraganglionnaires de localisation sinonasale
: à propos de 22 cas via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): M. Lombard, P. Rives, G. Michel, A. Moreau, F. Espitalier, O. Malard ObjectifLe but de l’étude est de définir les caractéristiques cliniques, la prise en charge et le pronostic des lymphomes non hodgkiniens extraganglionnaires à localisation sinonasale.Matériels et méthodesÉtude rétrospective menée entre 2004 ... περισσότερα »
Repérage peropératoire du nerf laryngé inférieur lors des thyroïdectomies
Repérage peropératoire du nerf laryngé inférieur lors des thyroïdectomies via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): A.-R. Ngo Nyeki, L.-R. Njock, J. Miloundja, J.-E. Evehe Vokwely, G. Bengono ObjectifCe travail a pour but de décrire les différents rapports anatomiques du nerf laryngé inférieur (NLI) lors de la chirurgie thyroïdienne sur une population d’Afrique centrale.Pat... περισσότερα »
Critères d’hospitalisation des infections dentaires à risque de cellulite cervicale
Critères d’hospitalisation des infections dentaires à risque de cellulite cervicale via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): N. Alotaibi, L. Cloutier, E. Khaldoun, E. Bois, M. Chirat, D. Salvan ButsDe nombreux patients avec des infections dentaires sont hospitalisés en raison du risque de cellulite cervicale. Le but de cette étude est d’identifier des facteurs de risque p... περισσότερα »
Les tendances relatives aux corps étrangers nasaux
dans le nord-est de la Malaisie : une expérience sur 5ans via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): A.A. Yaroko, B. Abdullah ObjectifsL’objectif de cette étude était de décrire les présentations les plus fréquentes et les résultats de la prise en charge des corps étrangers nasaux (CEN).Matériel et méthodeUne étude rétrospective a été menée sur une période de 5ans, de janvi... περισσότερα »
Scolarité de l’enfant sourd et bénéfice d’un diagnostic précoce
Scolarité de l’enfant sourd et bénéfice d’un diagnostic précoce via ScienceDirect Publication: Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale Publication date: November 2015 *Source:*Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 132, Issue 5 Author(s): M. François, M. Boukhris, N. Noel-Petroff ButApprécier l’impact d’une surdité bilatérale moyenne à sévère sur la scolarisation des enfants, et les facteurs pouvant influencer celle-ci, et évaluer les besoins de prise en charge spécialisée, autre que la rééducation ortho...περισσότερα »
Continuous Positive Airway Pressure Treatment Reduces Mortality in Elderly Patients with Moderate to Severe Obstructive Severe Sleep Apnea: A Cohort Study
Continuous Positive Airway Pressure Treatment Reduces Mortality in Elderly Patients with Moderate to Severe Obstructive Severe Sleep Apnea: A Cohort Study: by Qiong Ou, Yong-Chi Chen, Sheng-Qing Zhuo, Xiang-Ting Tian, Chun-Huan He, Xi-Lin Lu, Xing-Lin Gao Obstructive sleep apnea (OSA) is much more prevalent in older people than in middle-aged or young populations, and has been associated with cardiovascular disease. Continuous positive airway pressure (CPAP) is the first-line therapy for OSA, but its long-term clinical benefit in the elderly is unclear. Here, we carried out a pros... περισσότερα »
Association between Mouth Breathing and Atopic Dermatitis
Association between Mouth Breathing and Atopic Dermatitis in Japanese Children 2–6 years Old: A Population-Based Cross-Sectional Study: by Harutaka Yamaguchi, Saaya Tada, Yoshinori Nakanishi, Shingo Kawaminami, Teruki Shin, Ryo Tabata, Shino Yuasa, Nobuhiko Shimizu, Mitsuhiro Kohno, Atsushi Tsuchiya, Kenji Tani As mouth breathing is associated with asthma and otitis media, it may be associated with other diseases. Therefore, this population-based cross-sectional study evaluated the association of mouth breathing with the prevalences of various diseases in children. Preschool childr...περισσότερα »
The effects of entombment on water chemistry and bacterial assemblages in closed cryoconite holes on Antarctic glaciers
Closed cryoconite holes (CCHs) are small aquatic ecosystems enclosed in glacier surface ice and collectively contribute substantial aquatic habitat to inland Antarctica. We examined the morphology, geochemistry and bacterial diversity of 57 CCHs, spread over seven sites, located on five glaciers, covering a range of latitudes, elevations and distance from open seawater. Isotopes confirmed glacial ice as the initial water source, with water chemistry evolving through freeze concentration and photosynthetic processes to have conductivities ranging from <0.005 to >4 mS cm–1 and pH fr...περισσότερα »
A validated web-based tool to display individualised Crohn's disease predicted outcomes based on clinical, serologic and genetic variables
Summary Background Early treatment for Crohn's disease (CD) with immunomodulators and/or anti-TNF agents improves outcomes in comparison to a slower 'step up' algorithm. However, there remains a limited ability to identify those who would benefit most from early intensive therapy. Aim To develop a validated, individualised, web-based tool for patients and clinicians to visualise individualised risks for developing Crohn's disease complications. Methods A well-characterised cohort of adult patients with CD was analysed. Available data included: demographics; clinical characteris... περισσότερα »
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