Development and Validation of a Morphologic Obstructive Sleep Apnea Prediction Score: The DES-OSA Score.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Development and Validation of a Morphologic Obstructive Sleep Apnea Prediction Score: The DES-OSA Score.: BACKGROUND: Obstructive sleep apnea (OSA) is a common and underdiagnosed entity that favors perioperative morbidity. Several anatomical characteristics predispose to OSA. We developed a new clinical score that would detect OSA based on the patient's morphologic characteristics only. METHODS: Patients (n = 149) scheduled for an overnight polysomnography were included. Their morphologic metrics were compared, and combinations of them were tested for their ability to predict at leas... περισσότερα »
The Effect of Intraoperative Blood Glucose Management on Postoperative Blood Glucose Levels in Noncardiac Surgery Patients.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
The Effect of Intraoperative Blood Glucose Management on Postoperative Blood Glucose Levels in Noncardiac Surgery Patients.: BACKGROUND: Postoperative hyperglycemia has been associated with poor surgical outcome. The effect of intraoperative glucose management on postoperative glucose levels and the optimal glycemic threshold for initiating insulin are currently unknown. METHODS: We performed a retrospective cohort study of surgery patients who required intraoperative glucose management with data extracted from electronic medical records. In patients who required glucose management, ... περισσότερα »
Electroacupuncture Relieves Nerve Injury-Induced Pain Hypersensitivity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα
Electroacupuncture Relieves Nerve Injury-Induced Pain Hypersensitivity via the Inhibition of Spinal P2X7 Receptor-Positive Microglia.: BACKGROUND: Electroacupuncture (EA) has therapeutic effects on neuropathic pain induced by nerve injury; however, the underlying mechanisms remain unclear. In this study, we examined whether EA treatment relieves pain hypersensitivity via the down-regulation of spinal P2X7 receptor-positive (P2X7R+) microglia-mediated overexpression of interleukin (IL)-1[beta] and/or IL-18. METHODS: Male Sprague-Dawley rats underwent chronic constriction injury (CCI) ...περισσότερα »
Acute respiratory distress syndrome following cardiovascular surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches.: Purpose of review: This review gives an update on current treatment options and novel concepts on the prevention and treatment of the acute respiratory distress syndrome (ARDS) in cardiovascular surgery patients. Recent findings: The only proven beneficial therapeutic options in ARDS are those that help to prevent further ventilator-induced lung injury, such as prone position, use of lung-protective ventilation strategies, and extracorporeal membrane oxygenation. ... περισσότερα »
Jarisch-Herxheimer reaction when administering antimicrobial agents
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Leptospirosis and Jarisch-Herxheimer reaction: Learning points for clinicians Although not commonly seen in Japan, the incidence of leptospirosis reported in 2014 was the highest in the past 6 years. It is important to consider leptospirosis among patients who traveled to Okinawa, Japan, and to keep in mind Jarisch–Herxheimer reaction when administering antimicrobial agents to patients with leptospirosis. Case report A 59-year-old Japanese man with a history of hypertension presented with a complaint of fever and watery diarrhea. He climbed mountains, got lost accidentally and dru... περισσότερα »
The use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer: a nationwide population-based cohort study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
The use of adjunctive traditional Chinese medicine therapy and survival outcome in patients with head and neck cancer: a nationwide population-based cohort study: *Background:* Traditional Chinese medicine (TCM) is widely used in the treatment of patients with several types of cancer. However, no large-scale clinical studies have evaluated whether TCM is associated with better survival in patients with head and neck cancer (HNC). *Methods:* The Taiwan National Health Insurance Research Database was used to conduct a retrospective cohort study of patients with HNC between 2001 and ...περισσότερα »
Cookie bite cortical osteolytic lesions: a hint of skeletal metastasis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Cookie bite cortical osteolytic lesions: a hint of skeletal metastasis from bronchogenic carcinoma: Learning point for clinicians Cookie bite lesions indicate focal eccentric osteolytic destruction of the external cortex of a long tubular bone. These lesions are suggestive of cortical metastasis typically originating from bronchogenic carcinoma. Therefore, the lung should be the first target of investigation in patients with cookie bite cortical lesions. Introduction A cookie bite lesion indicates focal eccentric intracortical osteolytic destruction of a long tubular bone. Deutsch... περισσότερα »
Running, ischaemic stroke and carotid artery dissection
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Running, ischaemic stroke and carotid artery dissection: Learning point for clinicians Internal carotid artery dissection may occur in young healthy adults following exercise. It is important to have a low degree of suspicion for such cases, particularly in younger patients without typical cerebrovascular risk factors, as delay in diagnosis and appropriate management may result in excess morbidity and mortality. Case A previously healthy 60-year-old right-handed male presented to the emergency department with sudden-onset expressive dysphasia, diplopia, right-arm numbness and loss... περισσότερα »
Use of a mobile tower-based robot—The initial Xi robot experience in surgical oncology
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Use of a mobile tower-based robot—The initial Xi robot experience in surgical oncology: Background and Objectives The da Vinci Xi platform provides expanded movement of the arms relative to the base, theoretically allowing increased versatility in complex multi-field or multi-quadrant surgery. We describe the initial Xi experience in oncologic surgery at a tertiary cancer center. Methods One hundred thirty unique robot-assisted procedures were performed using the Xi between 2014 and 2015, 112 of which were oncology surgeries. For procedures involving multiple quadrants, the robot wa... περισσότερα »
Hydrogen sulfide (H2S) is a colorless gas found in the industry and in places such as sewers.Toxic effects of hydrogen sulfide
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Toxic effects of hydrogen sulfide: experience with three simultaneous patients Learning Point for Clinicians-H2S-QJM Hydrogen sulfide (H2S) is a colorless gas found in the industry and in places such as sewers. It can cause severe intoxication resulting in respiratory and neurological damage, and even death. Three men with intoxication by this compound are described. Methods for prevention of this problem should be urgently implemented. Case report Three healthy workers attending cleaning operation were found in a critical condition inside a 5-m sewage manhole. The first victim, a 50... περισσότερα »
Osteitis fibrosa cystica in primary hyperparathyroidism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Osteitis fibrosa cystica in primary hyperparathyroidism A 43-year-old Asian initially presented to her primary care physician (PCP) for chronic bilateral hip pain for which she tried analgesics and anti-inflammatory medication with minimal relief. She was found to have an abnormal X-ray of pelvic bone for which she was referred to orthopedic surgery for further evaluation. She underwent computed tomography (CT) of pelvis which revealed multiple lytic lesions in the pelvic bone, involving bilateral ilium and pubic bone, right acetabulum (Figure 1a), which was again managed conserva... περισσότερα »
Mandibular advancement appliances for the treatment of paediatric obstructive sleep apnea
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Mandibular advancement appliances for the treatment of paediatric obstructive sleep apnea: a systematic review: Objective: To evaluate the effectiveness of mandibular advancement appliances (MAAs) for treatment of pediatric obstructive sleep apnea (OSA). Methods: Several electronic databases (The Cochrane Database, EMBASE, Healthstar, MEDLINE, PubMed) were systematically searched, as well as a limited grey literature (Google Scholar) and manual searches. A health sciences librarian helped with the selection of Medical Subject Headings (MeSH), key words, and combinations of key word...περισσότερα »
Craniofacial anatomical magnetic resonance imaging and real-time speech imaging
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Impact of orthodontic appliances on the quality of craniofacial anatomical magnetic resonance imaging and real-time speech imaging: Aims: The aim of this work was to investigate the effects of commonly used orthodontic appliances on the magnetic resonance (MR) image quality of the craniofacial region, with special interest in the soft palate and velopharyngeal wall using real-time speech imaging sequences and anatomical imaging of the temporomandibular joints (TMJ) and pituitaries. Methods: Common orthodontic appliances were studied on 1.5 T scanner using standard spin and gradient...περισσότερα »
Adhesion of mutans streptococci to self-ligating ceramic brackets
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Adhesion of mutans streptococci to self-ligating ceramic brackets: in vivo quantitative analysis with real-time polymerase chain reaction: Objective: To analyze *in vivo* mutans streptococci (MS) adhesion to self-ligating ceramic brackets [Clarity-SL (CSL) and Clippy-C (CC)] and the relationships between bacterial adhesion and oral hygiene indices. Materials and methods: Four central incisor brackets from the maxilla and mandible were collected from 40 patients (20 patients per each bracket type) at debonding immediately after plaque and gingival indices were measured. Adhesions of ... περισσότερα »
Predictive value of masseter muscle thickness and bite force on Class II functional appliance treatment: a prospective controlled study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Predictive value of masseter muscle thickness and bite force on Class II functional appliance treatment: a prospective controlled study: Aim: To prospectively evaluate the functional capacity of the masticatory musculature as a predictive variable in determining functional appliance treatment outcomes in Class II/1 malocclusion children. Methods: Twenty Class II/1 malocclusion children (11.4±1.7 years) were treated with functional appliances during 1 year. Masseter muscle thickness and maximal molar bite force measurements, lateral cephalograms, and study casts were taken before an...περισσότερα »
Effects of rapid maxillary expansion on the midpalatal suture
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Effects of rapid maxillary expansion on the midpalatal suture: a systematic review: Objective: To identify and qualify the scientific evidence on the immediate and long-term effects of rapid maxillary expansion on the midpalatal suture in growing teenage or young adults, the related articles were selected. Materials and methods: Literatures were searched in the electronic databases, including Medline, Embase, Web of Science, and Cochrane Library. A methodologic-quality scoring (13-point) scale was used to evaluate the quality of the studies. Results: Twelve relevant articles were ... περισσότερα »
Regional facial asymmetries in unilateral orofacial clefts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Regional facial asymmetries in unilateral orofacial clefts: Objectives: Assess facial asymmetry in subjects with unilateral cleft lip (UCL), unilateral cleft lip and alveolus (UCLA), and unilateral cleft lip, alveolus, and palate (UCLP), and to evaluate which area of the face is most asymmetrical. Methods: Standardized three-dimensional facial images of 58 patients (9 UCL, 21 UCLA, and 28 UCLP; age range: 8.6–12.3 years) and 121 controls (age range 9–12 years) were mirrored and distance maps were created. Absolute mean asymmetry values were calculated for the whole face, cheek, nos... περισσότερα »
Th17 regulating lower airway disease.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Th17 regulating lower airway disease.: Purpose of review: Th17 lymphocytes are now widely believed to be critical for the regulation of various chronic immune diseases, including asthma and chronic obstructive pulmonary disease. In this review, we discuss the current understanding of the role of Th17 cells in the pathogenesis of different asthma phenotypes and chronic obstructive pulmonary disease. Recent findings: It has been recently reported that Th17 cells and also a new population of Th17/Th2 cells accumulate in bronchoalveolar lavage fluid of asthmatic patients, and positively ... περισσότερα »
Long-term results of remodelling the facial bones with a soft moulding helmet in beagles: the “reciprocally stimulated growth” hypothesis
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 12 δευτερόλεπτα
Long-term results of remodelling the facial bones with a soft moulding helmet in beagles: the “reciprocally stimulated growth” hypothesis: Facial deformity is often seen in infants with deformational plagiocephaly and it usually improves with conservative management. However, we know of few studies of the effect of helmet treatment on the facial skeleton. Our aim therefore was to find out its long-term effects on skull remodelling, and on the shape of the face. Seven beagles wore helmets for seven weeks after birth. Seven study beagles and 3 controls were killed and we measured the ... περισσότερα »
Evaluation of alveolar bone dimensions in unilateral palatally impacted canine: a cone-beam computed tomographic analyses
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 19 δευτερόλεπτα
Evaluation of alveolar bone dimensions in unilateral palatally impacted canine: a cone-beam computed tomographic analyses: Introduction: The purpose of this study was to evaluate the alveolar bone dimensions and arch perimeter discrepancy in unilateral palatally impacted canines. Methods: This retrospective split-mouth study reviewed 207 cone-beam computed tomography (CBCT) scans of patients with unilateral or bilateral impacted canines referred for orthodontic treatment. Out of 207 CBCT scans, only 39 scans in which canines were unilaterally palatally impacted were approved for th... περισσότερα »
Physical and Functional Ability Recovery Patterns and Quality of Life after Immediate Autologous Latissimus Dorsi Breast Reconstruction: A 1-Year Prospective Observational Study
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Background: The authors evaluated arm and shoulder function and quality of life prospectively after breast reconstruction with the latissimus dorsi flap. Methods: Muscle strength was checked by manual muscle test and range of motion preoperatively and then at five postoperative time points: week 2, week 6, month 3, month 6, and month 12. Functional disability and quality of life were also measured by the Disabilities of the Arm, Shoulder and Hand questionnaire and the 36-Item Short-Form Health Survey. The assessments were performed preoperatively and then at three post...περισσότερα »
Ferraro’s Fundamentals of Maxillofacial Surgery, 2nd Edition
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1I8VSH3 via IFTTT
Midcheek Lift Using Facial Soft-Tissue Spaces of the Midcheek
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Background: This article describes a preperiosteal midcheek lift technique performed by means of the midcheek soft-tissue spaces by precise release of the retaining ligaments that separate the spaces. Methods: From November of 2009 to June of 2014, 184 patients underwent this procedure. A transcutaneous lower eyelid blepharoplasty incision was used to access the preseptal space. Medially, the orbicularis oculi origins and tear trough ligament are released sharply, connecting the dissection with the premaxillary space. More laterally, the orbicularis retaining ligament ...περισσότερα »
Effectiveness of Conservative Therapy and Helmet Therapy for Positional Cranial Deformation
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1I8VS9Z via IFTTT
Abdominoplasty with Customized Transverse Musculoaponeurotic Plications
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Background: The standard abdominoplasty technique uses a wide, vertically oriented plication of the rectus sheath to narrow the waistline. However, this plication is not always enough to achieve good cosmetic and functional results. This is also the case with other plication techniques. To strengthen the abdominal wall at the points of greatest weakness in each particular patient, the authors have developed a personal technique consisting of customized transverse plications at the points of maximum protrusion in the musculoaponeurotic layer, in addition to the classic ... περισσότερα »
Current Concepts in Lower Extremity Reconstruction
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Learning Objectives: After studying this article, the participant should be able to: 1. Understand the existing principles for lower extremity reconstruction for both traumatic and ablative defects. 2. Understand the important factors for lower extremity reconstruction–based anatomical regions. 3. Discuss perforator flaps and their application in lower extremity reconstruction. Summary: The Gustilo-Anderson open fracture classification is briefly reviewed. A comprehensive overview of the available flaps and methods for lower extremity reconstruction is provided. from #... περισσότερα »
Dynamics of Gluteal Cleft Morphology in Lower Body Lift: Predictors of Unfavorable Outcomes
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Background: The number of lower body lifts is increasing with the increase in post–bariatric surgery patients. An undesirable result of the lower body lift is elongation of the gluteal cleft. The authors assessed their patients for gluteal cleft elongation to determine predictors of this unfavorable result. Methods: Lower body lift excision patterns were classified based on their relationship to the gluteal cleft. Type I patterns were superior to the gluteal cleft; type II were central, partially incorporating the superior portion of the cleft; and type III were charac... περισσότερα »
The Challenges in Presenting Complex Studies
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1I8VLv3 via IFTTT
The Effect of Abdominoplasty and Outcome of Rectus Fascia Plication on Health-Related Quality of Life in Post–Bariatric Surgery Patients
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 20 δευτερόλεπτα
[image: image]Background: The authors prospectively evaluated the effect of isolated abdominoplasty with or without rectus fascia plication on the physical, functional, and psychosocial dimensions of health-related quality of life in post–bariatric surgery patients. They also evaluated whether the objectively measured amount of abdominal excess skin affects the discomfort of excess abdominal skin and changes in health-related quality of life after abdominoplasty. Methods: Ninety-four post–bariatric surgery patients answered questionnaires regarding their experience of excess skin and... περισσότερα »
Innate lymphoid type 2 cells in chronic rhinosinusitis.
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Innate lymphoid type 2 cells in chronic rhinosinusitis.: Purpose of review: Innate lymphoid type 2 cells (ILC2) have a critical role in the initiation and regulation of type 2 immune responses and are recognized as an important source of type-2 cytokines. Here, we present recent findings of the role of ILC2 in the integration, processing, and coordination of innate and adaptive immune processes and focus on the potential role of ILC2 in the context of chronic rhinosinusitis. Recent findings: Recent research has shown the complex crosstalk that occurs between ILC2 and different innate... περισσότερα »
Should Free Thyroxine Go Back into the Routine Thyroid Profile?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
Should Free Thyroxine Go Back into the Routine Thyroid Profile?: Exp Clin Endocrinol Diabetes 2015; 123: 594-597 DOI: 10.1055/s-0035-1559782 Background: Many clinical chemistry laboratories offer thyroid-stimulating hormone (TSH) alone as a first-line test of thyroid function, and only reflex a free thyroxine (fT4) test if the TSH result is abnormal (i. e., outside of the laboratory reference range). In secondary hypothyroidism, a low fT4 may be accompanied by a low or a normal TSH level. A testing strategy that measures baseline TSH only risks missing cases of secondary hypothyroi... περισσότερα »
Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer: Exp Clin Endocrinol Diabetes 2015; 123: 598-603 DOI: 10.1055/s-0035-1559780 Purpose: Growing evidence suggests that interleukin-18 (IL-18) levels may affect neoplasia and that single nucleotide polymorphisms (SNPs) within IL-18 gene may influence its production. In this study, we evaluated whether IL-18 and IL-18 receptor (IL-18R) polymorphisms are associated with the development and clinicopathological features of papillary thyroid carcinoma (PTC). Materials and M... περισσότερα »
Airway Management via Laryngeal Mask
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 24 δευτερόλεπτα
in Laryngotracheal Resection by Zardo, Patrick via The Thoracic and Cardiovascular Surgeon Reports THORAC CARDIOV SURG Reports DOI: 10.1055/s-0035-1556061 We present a case of impassable subglottic stenosis scheduled for tracheal resection and reconstruction managed by establishing a supraglottic airway. Despite careful preoperative evaluation, the stenosis was localized higher than anticipated, rendering conventional intubation impossible. Laryngeal mask bridging to cross-field ventilation was feasible and jet ventilation and cardiopulmonary bypass were available as emergency strateg...περισσότερα »
Facial flushing response to alcohol and the risk of esophageal squamous cell carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
: A comprehensive systematic review and meta-analysis via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: February 2016 *Source:*Cancer Epidemiology, Volume 40 Author(s): Juliana Andrici, Sharon X.H. Hu, Guy D. Eslick ObjectiveThe alcohol flushing response is common among ethnic East Asian populations, and has been associated with an increased risk in developing esophageal cancer, especially squamous cell esophageal cancer (ESCC). We aimed to quantify the relationship between the facial flushing response to alcohol consumption and ESCC.MethodsWe conducted ... περισσότερα »
Free flap engraftment despite early pedicle thrombosis due to antithrombin deficiency
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Free flap engraftment despite early pedicle thrombosis due to antithrombin deficiency: AbstractEarly pedicle occlusion following microvascular flap transfer is the major cause for flap loss, which is most often surgery-associated and occurs usually within the first 48 h postoperatively. In unusual postoperative courses, patient-associated factors (e.g. thrombophilic disposition) have to be investigated. We present a case of posttraumatic reconstruction of a full-thickness skin defect of the foot in a healthy young man with a microvascular flap. At day 4 after surgery, a complete p... περισσότερα »
Premenstrual Syndrome and Subsequent Risk of Hypertension in a Prospective Study
Alexandros G. SfakianakisστοΟγκολογίαΠριν από 27 δευτερόλεπτα
The prevalence of hypertension is increasing among younger women, and new strategies are needed to identify high-risk women who should be targets for early intervention. Several mechanisms underlying hypertension might also contribute to premenstrual syndrome (PMS), but whether women with PMS have a higher risk of subsequently developing hypertension has not been assessed. We prospectively evaluated this possibility in a substudy of the Nurses' Health Study II. Participants were 1,257 women with clinically significant PMS (1991–2005) and 2,463 age-matched comparison women with few ... περισσότερα »
Reply: The Effect of Adipose-Derived Stem Cell Supernatant on Reperfusion Injury
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 27 δευτερόλεπτα
No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Xp3BCu via IFTTT
Technical Refinements in Autologous Hand Rejuvenation
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 27 δευτερόλεπτα
[image: image]Summary: The aging hand is characterized by skin changes and soft-tissue deflation, which leads to rhytides, dermal atrophy, and distinct anatomical structures. Soft-tissue deflation and prominent hand anatomy can be corrected with volume augmentation using dermal fillers or lipofilling. Fat transfer volumizes the hand with prolonged durability and efficacy, autologous tissue replacement, and possible dermal regeneration. The senior author's (R.J.R.) technique for hand rejuvenation is described, which uses minimal access and blunt dissection to effectively augment the ...περισσότερα »
Local Flap for Reconstruction of Nonmelanoma Facial Skin Cancer
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 27 δευτερόλεπτα
[image: image]No abstract available from #Aesthetics via alexandrossfakianakis on Inoreader http://ift.tt/1Xp3Ayt via IFTTT
The Effect of Autologous Fat Graft with Different Surgical Repair Methods on Nerve Regeneration in a Rat Sciatic Nerve Defect Model
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 27 δευτερόλεπτα
[image: image]Background: The aim of this study was to evaluate the efficacy of autologous fat graft with different surgical repair methods on reconstruction of a 10-mm-long rat sciatic nerve defect model. Methods: One hundred forty-four sciatic nerves were operated on in 72 Wistar rats. The right limbs were assigned as group A (n = 72) and the left limbs as group B (n = 72). In group B, autologous fat graft was added to the surgical area so as to stay in contact with the coaptation site. Nerve regeneration was evaluated by walking track analysis, Sciatic Functional Index, pin-prick,... περισσότερα »
A Systematic Review and Head-to-Head Meta-Analysis of Outcomes following Direct-to-Implant versus Conventional Two-Stage Implant Reconstruction
Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 27 δευτερόλεπτα
[image: image]Background: Innovative approaches to reconstruction have ushered in an era of breast reconstruction in which direct-to-implant procedures can provide an immediately reconstructed breast. Balancing the benefits against its technical challenges is vital. The authors evaluated the safety and efficacy of using direct-to-implant versus conventional two-stage reconstruction through a systematic meta-analysis. Methods: A literature search identified all articles published after 1999 involving prosthetic-based breast reconstruction as a two-stage tissue expander/implant or dir... περισσότερα »
Reply to Messori
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 27 δευτερόλεπτα
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1lfXFj4 via IFTTT
Newest Treatments for Hepatitis C: How Can We Manage Sustainability?
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 27 δευτερόλεπτα
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1XcgNQl via IFTTT
What Medicare Is Missing
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 27 δευτερόλεπτα
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1XcgNzQ via IFTTT
Immunosuppressed Patient Presenting With Fever, Interstitial Pneumonia, and Brain Lesions
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 27 δευτερόλεπτα
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1XcgKEd via IFTTT
The role of the circle of Willis in internal carotid artery stenosis and anatomical variations: a computational study based on a patient-specific three-dimensional model
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
The role of the circle of Willis in internal carotid artery stenosis and anatomical variations: a computational study based on a patient-specific three-dimensional model: Background: The aim of this study is to provide better insights into the cerebral perfusion patterns and collateral mechanism of the circle of Willis (CoW) under anatomical and pathological variations. Methods: In the current study, a patient-specific three-dimensional computational model of the CoW was reconstructed based on the computed tomography (CT) images. The Carreau model was applied to simulate the non-Newto... περισσότερα »
Can Physical Exercise Enhance Long-Term Memory?
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Can Physical Exercise Enhance Long-Term Memory?: “Our research indicates that exercise-induced increase in neurogenesis improves pattern separation by supporting unique and detailed long-term representations of similar but nevertheless different memory items. Pattern separation is involved in many memory tasks of everyday life. For example, when learning the game of chess, it is critically important to remember the different shapes of pieces like the pawn and bishop. Similarly, remembering the precise pattern of pieces on the board during a previously successful opening or endgame ... περισσότερα »
Medic student's revolt with his co-workers against an abusive boss led to 30-year career in emergency medicine
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Medic student's revolt with his co-workers against an abusive boss led to 30-year career in emergency medicine: Medics carrying firearms has been hotly debated by EMS professionals for the last couple of years, but it’s old news to Ed Gilbertson, Program Director of Community Paramedicine for Little Rock’s Metropolitan EMS system (MEMS). "People I rode with 30 years ago carried guns, but it wasn’t because of the patients or the neighborhood," says the 53-year-old RN and former paramedic. "It was because of their boss." *Fear and loathing in Little Rock* Gilbertson is referring to...περισσότερα »
Emergence agitation in children: risk factors, prevention, and treatment
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Emergence agitation in children: risk factors, prevention, and treatment: AbstractEmergence agitation (EA) in children is a major postoperative issue that increases the risk of patient self-harm, places a burden on nursing staff, and reduces parent satisfaction with treatment. Risk factors for EA include age, preoperative anxiety, patient personality, pain, anesthesia method, and surgical procedure. Sevoflurane and desflurane are widely used anesthetics due to their low blood/gas partition coefficients, but they have recently been posited as a cause of EA in children. The perioperat... περισσότερα »
Use of Objective Neurocognitive Measures to Assess the Psychological States that Influence Return to Sport Following Injury
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Use of Objective Neurocognitive Measures to Assess the Psychological States that Influence Return to Sport Following Injury: AbstractThere is growing interest in the effects of psychological states on human performance, especially with those who have suffered debilitating injury and are attempting to return to sport (RTS). Current research methods measure psychological states through validated questionnaires; however, these outcomes only allow for subjective assessment and may be unintentionally biased. Application of objective neurocognitive measures correlated with psychological ...περισσότερα »
The Biomechanics of the Modern Golf Swing: Implications for Lower Back Injuries
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
The Biomechanics of the Modern Golf Swing: Implications for Lower Back Injuries: AbstractThe modern golf swing is a complex and asymmetrical movement that places an emphasis on restricting pelvic turn while increasing thorax rotation during the backswing to generate higher clubhead speeds at impact. Increasing thorax rotation relative to pelvic rotation preloads the trunk muscles by accentuating their length and allowing them to use the energy stored in their elastic elements to produce more power. As the thorax and pelvis turn back towards the ball during the downswing, more skill... περισσότερα »
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis: Abstract BackgroundResistance training (RT) is effective for glycemic control in type 2 diabetes mellitus (T2DM) patients. However, the characteristics of an RT program that will maximize its effect and those of patients that will especially benefit from RT are unknown. ObjectiveThe objectives of this systematic review were to identify via a comprehensive meta-analysis the characteristics of an RT pro... περισσότερα »
Is acute idiopathic pericarditis associated with recent upper respiratory tract infection or gastroenteritis? A case-control study
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives The aim of this study was to assess the association of a clinical diagnosis of acute idiopathic pericarditis (AIP), and a reported upper respiratory tract infection (URTI) or gastroenteritis (GE) in the preceding month. Design Patients who were hospitalised with a first diagnosis of AIP were retrospectively compared with a control group of patients admitted with deep vein thrombosis (DVT), matched by gender and age. Setting Primary and secondary care level; one hospital serving a population of about 170 000. Participants A total of 51 patients with AIP were include... περισσότερα »
Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design Systematic review and meta-analysis of fracture risk and changes in bone mineral density with long-term ICS use in asthma. Methods We initially searched MEDLINE and EMBASE in July 2013, and performed an updated PubMed search in December 2014. We selected randomised controlled trials (RCTs) and controlled observational studies of any ICS (duration at least 12 months) compared to non-ICS use in patients with asthma. We cond...περισσότερα »
A cross-sectional multicentre study of cardiac risk score use in the management of unstable angina and non-ST-elevation myocardial infarction
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Objectives Quantitative risk assessment in unstable angina (UA) and non-ST-elevation myocardial infarction (NSTEMI), by using cardiac risk scores, is recommended in international guidelines. However, a gap between recommended care and actual practice exists, as these instruments seem underused in practice. The present study aimed to determine the extent of cardiac risk score use and to study factors associated with lower or higher cardiac risk score use. Setting 13 hospitals throughout the Netherlands. Participants A retrospective chart review of 1788 charts of patients with U... περισσότερα »
Argus II retinal prosthesis malrotation and repositioning
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Seider MI, Hahn P from #Medicine via ola Kala on Inoreader http://ift.tt/1lgQIy9 via IFTTT
Causes d’échec à la coloscopie totale au centre hospitalier universitaire (CHU) de Cocody, Abidjan (Côte-d’Ivoire)
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Résumé But Déterminer les facteurs liés à une coloscopie incomplète au CHU de Cocody. Matériels et méthodes Il s'agissait d'une étude rétrospective allant du 1er septembre 1993 au 15 août 2009, ayant intéressé le registre des coloscopies du CHU de Cocody. Tous les comptes rendus de coloscopies ont été inclus. Les paramètres étudiés étaient: le motif de la coloscopie, l'âge, le sexe, la qualité de la préparation colique, la présence de boucles ou spasmes au cours de l'examen, les résultats de la coloscopie et le franchissement ou non du cæcum. L'analyse des résultats a été faite gr...περισσότερα »
Inter-Relationship between Rhinitis and Conjunctivitis in Allergic Rhinoconjunctivitis and Associated Risk Factors in Rural Children
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Inter-Relationship between Rhinitis and Conjunctivitis in Allergic Rhinoconjunctivitis and Associated Risk Factors in Rural UK Children: by Michael R. Perkin, Tara Bader, Alicja R. Rudnicka, David P. Strachan, Christopher G. Owen Objective Allergic conjunctivitis (AC) is a common condition, especially in childhood. The extent to which it occurs concurrently with or independently from allergic rhinitis (AR) has not been well described. Aim To examine the inter-relationship between rhinitis and conjunctivitis and the epidemiological risk factors for these conditions in a rural UK... περισσότερα »
Effect of Paclitaxel on Antitumor Activity of Cyclophosphamide: Study on Two Transplanted Tumors
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Effect of Paclitaxel on Antitumor Activity of Cyclophosphamide: Study on Two Transplanted Tumors in Mice: Antitumor effect of paclitaxel used as the monotherapy or in combination with cyclophosphamide was studied on CBA/LacSto mice with transplanted LS and RLS tumors characterized by high (LS) and low (RLS) sensitivity to cyclophosphamide. The therapeutic effects of cyclophosphamide and paclitaxel were summed in animals with drug-resistant RLS tumor, while combined use of these drugs in LS tumor highly sensitive to the apoptogenic effect of cyclophosphamide was no more effective th... περισσότερα »
Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 37 δευτερόλεπτα
Oligopeptides of Chorionic Gonadotropin β-Subunit in Induction of T Cell Differentiation into Treg and Th17: The role of oligopeptides of chorionic gonadotropin β-subunit (LQGV, AQGV, and VLPALP) in induction of differentiation into T-regulatory lymphocytes (Treg) and IL-17-producing lymphocytes (Th17) was studied in an *in vitro* system. Chorionic gonadotropin and oligopeptides promoted CD4+ cell differentiation into functionally active Treg (FOXP3+GITR+ and FOXP3+CTLA-4+), while chorionic gonadotropin and AQGV additionally stimulated IL-10 production by these cells. In parallel, ... περισσότερα »
Coordination in Climbing: Effect of Skill, Practice and Constraints Manipulation
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Coordination in Climbing: Effect of Skill, Practice and Constraints Manipulation: Abstract BackgroundClimbing is a physical activity and sport involving many subdisciplines. Minimization of prolonged pauses, use of a relatively simple path through a route and smooth transitions between movements broadly define skilled coordination in climbing. ObjectivesTo provide an overview of the constraints on skilled coordination in climbing and to explore future directions in this emerging field. MethodsA systematic literature review was conducted in 2014 and retrieved studies reporting... περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 39 δευτερόλεπτα
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Effects of Gastric Bypass and... περισσότερα »
Short-term changes in tinnitus pitch related to audiometric shape in sudden sensorineural hearing loss
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 39 δευτερόλεπτα
Short-term changes in tinnitus pitch related to audiometric shape in sudden sensorineural hearing loss: Sudden sensorineural hearing loss (SSNHL) is frequently accompanied by tinnitus. This study investigated the relationships between new-onset tinnitus and audiometric parameters in SSNHL patients. AbstractObjective Sudden sensorineural hearing loss (SSNHL) is frequently accompanied by tinnitus. This study investigated the relationships between new-onset tinnitus and audiometric parameters in SSNHL patients. Methods Sixty-one patients with SSNHL with new-onset tinnitus were enroll...περισσότερα »
Headache in acute ischaemic stroke: a lesion mapping study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Headache in acute ischaemic stroke: a lesion mapping study: Headache is a common symptom in acute ischaemic stroke, but the underlying mechanisms are incompletely understood. The aim of this lesion mapping study was to identify brain regions, which are related to the development of headache in acute ischaemic stroke. Patients with acute ischaemic stroke (*n = *100) were assessed by brain MRI at 3 T including diffusion weighted imaging. We included 50 patients with stroke and headache as well as 50 patients with stroke but no headache symptoms. Infarcts were manually outlined and im...περισσότερα »
Comparison of universal screening with targeted high-risk case finding for diagnosis of thyroid disorders
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Comparison of universal screening with targeted high-risk case finding for diagnosis of thyroid disorders: Objective Debate about the need for universal screening of thyroid dysfunction in pregnancy is ongoing. The present study aimed to compare universal screening with targeted high-risk case findings for early diagnosis of thyroid disorders in Iranian pregnant women. Study design This cross-sectional prospective study was carried out on 1600 pregnant women in their first trimester. A checklist, including all related risk factors recommended by The American Thyroid Association, wa... περισσότερα »
Myositis-specific autoantibodies: an important tool to support diagnosis of myositis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Myositis-specific autoantibodies: an important tool to support diagnosis of myositis: Abstract The idiopathic inflammatory myopathies are characterized by muscle weakness, skin disease and internal organ involvement. Autoimmunity is known to have a role in myositis pathogenesis, and myositis-specific autoantibodies, targeting important intracellular proteins, are regarded as key biomarkers aiding in the diagnosis of patients. In recent years, a number of novel myositis autoantibodies including anti-TIF1, anti-NXP2, anti-MDA5, anti-SAE, anti-HMGCR and anti-cN1A have been identified ... περισσότερα »
Microbiota disorders and food hypersensitivity in autism spectrum disorders; what do we know?
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 41 δευτερόλεπτα
Microbiota disorders and food hypersensitivity in autism spectrum disorders; what do we know?: 2015-11-24T23-30-06Z *Source:* Journal of Experimental and Integrative Medicine Patrycja Szachta, Anna Bartnicka, Miroslawa Galecka, Karolina Skonieczna-Zydecka. Pathogenesis of autism spectrum disorders (ASD) is probably multifactorial. Many studies have shown intestinal dysbiosis in children with autism. Moreover, gastrointestinal disturbances, probably resulting from abnormal microbiota composition, are commonly reported in children with autism. Another aspect, that may have negative ...περισσότερα »
Damage control surgery and combat-related maxillofacial and cervical injuries
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 42 δευτερόλεπτα
: a systematic review via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 24 November 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Darryl C. Tong, John Breeze Damage control surgery involves rapid assessment, life-saving resuscitation, and abbreviated surgery for a patient with severe injuries. Traditionally the concept of damage control surgery has been restricted to penetrating abdominal injuries, but more recently it has been expanded to areas outside of the abdomen including the maxillofacial and neck regions. Howev... περισσότερα »
Multigenerational autosomal dominant inheritance of 5p chromosomal deletions
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 55 δευτερόλεπτα
Deletion of the short arm of chromosome 5 (5p-) is associated with phenotypic features including a cat-like cry in infancy, dysmorphic facial features, microcephaly, and intellectual disability, and when encompassing a minimal critical region, may be defined as Cri-du-Chat syndrome (CdCS). Most 5p deletions are de novo in origin, and familial cases are often associated with translocation and inversion. Herein, we report three multigenerational families carrying 5p terminal deletions of different size transmitted in an autosomal dominant manner causing variable clinical findings. ... περισσότερα »
Clinical and mutation profile of multicentric osteolysis nodulosis and arthropathy
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 55 δευτερόλεπτα
Multicentric osteolysis nodulosis and arthropathy (MONA) is an infrequently described autosomal recessive skeletal dysplasia characterized by progressive osteolysis and arthropathy. Inactivating mutations in MMP2, encoding matrix metalloproteinase-2, are known to cause this disorder. Fifteen families with mutations in MMP2 have been reported in literature. In this study we screened thirteen individuals from eleven families for MMP2 mutations and identified eight mutations (five novel and three known variants). We characterize the clinical, radiographic and molecular findings in ...περισσότερα »
Sleep disturbance as a proximal predictor of suicidal intent in recently hospitalized attempters
Alexandros G. SfakianakisστοΥπνική Άπνοια και Διαταραχές ΎπνουΠριν από 1 ώρα
Sleep disturbance as a proximal predictor of suicidal intent in recently hospitalized attempters: • A total of 127 hospitalised suicide attempters were interviewed within 2 weeks post-attempt.• The suicide attempters retrospectively assessed insomnia and mean sleep time for 2 weeks pre-attempt.• Insomnia, short sleep, and insomnia with short sleep predicted suicidal intent.• Insomnia and short sleep partially mediated various predictors' effect on intent.• Improving sleep in suicidal subjects may reduce the lethality of suicidal acts.
Quantitative Measures of Swallowing Deficits in Patients With Parkinson's Disease
Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 1 ώρα
Quantitative Measures of Swallowing Deficits in Patients With Parkinson's Disease: Objective: Dysphagia and associated aspiration pneumonia are commonly reported sequelae of Parkinson’s disease (PD). Previous studies of swallowing in patients with PD have described prolonged pharyngeal transit time, delayed onset of pharyngeal transit, cricopharyngeal (CP) achalasia, reduced pharyngeal constriction, and slowed hyolaryngeal elevation. These studies were completed using inconsistent evaluation methodology, reliance on qualitative analysis, and a lack of a large control group, resultin...περισσότερα »
Complete and partial XYLT1 deletion in a patient with neonatal short limb skeletal dysplasia
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 1 ώρα
We report on a boy with a neonatal short limb skeletal dysplasia with serious medical complications, associated with one intragenic and one complete deletion of *XYLT1*. *XYLT1* mutations have recently been reported as causative in recessive Desbuquois skeletal dysplasia (DBSD), but the skeletal features in our patient do not fit this diagnosis. It is possible that the phenotype of *XYLT1* mutations extends to more aspecific types of short limb skeletal dysplasias and not to DBSD alone. © 2015 Wiley Periodicals, Inc. from Genes via ola Kala on Inoreader http://ift.tt/1LyJX02 via... περισσότερα »
SOX9 p.Lys106Glu mutation causes acampomelic campomelic dysplasia: Prenatal and postnatal clinical findings
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 1 ώρα
from Genes via ola Kala on Inoreader http://ift.tt/1Ns4hHV via IFTTT
Hepatoblastoma in a male with MECP2 duplication syndrome
Alexandros G. SfakianakisστοEvolution of a geneΠριν από 1 ώρα
from Genes via ola Kala on Inoreader http://ift.tt/1LyJUBn via IFTTT
Regeneration Process of Fungiform Taste Buds After Severing the Chorda Tympani Nerve During Middle Ear Surgery
Alexandros G. SfakianakisστοΓεύση και ΌσφρησηΠριν από 1 ώρα
Long-term Follow-up Results of Regeneration Process of Fungiform Taste Buds After Severing the Chorda Tympani Nerve During Middle Ear Surgery: Objective: To elucidate the regeneration process of fungiform taste buds after severing the chorda tympani nerve (CTN) by confocal laser scanning microscopy in vivo. Methods: In 7 consecutive patients whose CTN was severed during tympanoplasty, an average of 10 fungiform papillae in the midlateral region of the tongue were periodically observed, and the number of taste buds was counted until 12 to 24 months after surgery. Gustatory function...περισσότερα »
Congenital heart disease, atlantoaxial instability, tracheal and subglottic stenosis, a predisposition to respiratory complications, hypothyroidism, and macroglossia leading to sleep disordered breathing
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Sevoflurane and bradycardia in infants with trisomy 21: A case report and review of the literature: Various perioperative concerns have been reported in patients with trisomy 21 including associated congenital heart disease, atlantoaxial instability, tracheal and subglottic stenosis, a predisposition to respiratory complications, hypothyroidism, and macroglossia leading to sleep disordered breathing. The recent literature has also suggested a propensity for the development of significant bradycardia during inhalation induction with sevoflurane. We present a 2-year-old girl with tris... περισσότερα »
Prevalence and Ethnic Variation of Pre-auricular Sinuses in Children
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Prevalence and Ethnic Variation of Pre-auricular Sinuses in Children: Pre-auricular sinus (PAS) describes a congenital ear malformation presenting as a pit or sinus that may become infected, often requiring antibiotics and/or surgical excision. Although the presentation of PAS in otolaryngology clinics is not uncommon, there is limited epidemiological data regarding this malformation in children. Some evidence also suggests a potential ethnic variation in prevalence rates and potential heritability patterns within families, however these have yet to be proven. This study is the firs... περισσότερα »
Stridor and Apnea as the Initial Presentation of Primary Hypoparathyroidism
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Stridor and Apnea as the Initial Presentation of Primary Hypoparathyroidism: We present a previously undescribed case of stridor and apnea as the initial presentation of primary hypoparathyroidism. A neonate presenting with these symptoms was initially diagnosed with laryngopharyngeal reflux and laryngomalacia. After failing medical management, she underwent supraglottoplasty with improvement of stridor, but persistent apneic events. Further work-up showed severe hypocalcemia due to hypoparathyroidism. Subsequent genetic testing revealed a diagnosis of Bartter Syndrome Type V, a rar...περισσότερα »
The Galker test of speech reception in noise; associations with background variables, middle ear status, hearing, and language in Danish preschool children
Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 1 ώρα
The Galker test of speech reception in noise; associations with background variables, middle ear status, hearing, and language in Danish preschool children: We tested “the Galker test”, a speech reception in noise test developed for primary care for Danish preschool children, to explore if the children's ability to hear and understand speech was associated with gender, age, middle ear status, and the level of background noise. AbstractPURPOSE We tested “the Galker test”, a speech reception in noise test developed for primary care for Danish preschool children, to explore if the ch... περισσότερα »
A Proteomic Characterization of Non-typeable Haemophilus influenzae (NTHi) lysates
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A Proteomic Characterization of NTHi lysates: Non-typeable Haemophilus influenzae (NTHi) is a ubiquitous bacterial pathogen which accounts for a majority of human upper respiratory tract infections. Laboratory lysate preparations from this bacterium are commonly utilized to investigate the promulgation of inflammatory responses in respiratory and middle ear epithelium both in vivo and in vitro. We undertook an unbiased proteomics based analysis of NTHi lysate preps to: a) identify abundant bacterial proteins present in these lysates that could play a role in NTHi biological effects ... περισσότερα »
Characterization of B-Cells in Tonsils of Patients Diagnosed with Pediatric Autoimmune Neuropsychiatric Disorder Associated Streptococcus
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Characterization of B-Cells in Tonsils of Patients Diagnosed with Pediatric Autoimmune Neuropsychiatric Disorder Associated Streptococcus: To determine if Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS) patients demonstrate a significantly different number of B-Cells or markers of activity when compared to recurrent Group A Streptococcus or Obstructive Sleep Apnea patients. AbstractObjective To determine if Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS) patients demonstrate a significantly different numb...περισσότερα »
Congenital hairy polyp of the oropharynx presenting as an esophageal mass in a neonate, a case report and literature review
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Congenital hairy polyp of the oropharynx presenting as an esophageal mass in a neonate, a case report and literature review: To review the literature of congenital hairy polyps and describe the clinical presentation, operative management, and histologic findings of a congenital hairy polyp arising from the palatopharyngeus muscle in a neonate with recurrent choking episodes. AbstractPurpose To review the literature of congenital hairy polyps and describe the clinical presentation, operative management, and histologic findings of a congenital hairy polyp arising from the palatophary... περισσότερα »
Origins of the Binocular Head Mirror: the Mystery of Dr. Clar, Clarified
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Origins of the Binocular Head Mirror: the Mystery of Dr. Clar, Clarified: References to Dr. Clar's mirror are regularly found in collections of old medical instruments. While often-cited and emblematic, the origins of the name and the person behind the mirror remain unclear. For this reason, it is necessary to look back again into this somewhat mysterious and complicated history [1–3]. A recent historical note investigated wether the name of this time-honored mirror was related to a physician and suggested other clues for the naming of this medical instrument [4].
Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis: Objectives We aimed to assess the association between long-term use of inhaled corticosteroids (ICS) and bone adverse effects in patients with asthma. Design Systematic review and meta-analysis of fracture risk and changes in bone mineral density with long-term ICS use in asthma. Methods We initially searched MEDLINE and EMBASE in July 2013, and performed an updated PubMed search in December 2014. We selected randomised controlled tria...περισσότερα »
Is acute idiopathic pericarditis associated with recent upper respiratory tract infection or gastroenteritis? A case-control study
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Is acute idiopathic pericarditis associated with recent upper respiratory tract infection or gastroenteritis? A case-control study: Objectives The aim of this study was to assess the association of a clinical diagnosis of acute idiopathic pericarditis (AIP), and a reported upper respiratory tract infection (URTI) or gastroenteritis (GE) in the preceding month. Design Patients who were hospitalised with a first diagnosis of AIP were retrospectively compared with a control group of patients admitted with deep vein thrombosis (DVT), matched by gender and age. Setting Primary and seco... περισσότερα »
Journal of Oral Science Research
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
. Year *2015* Issue *10* is now available on CAOD. *In this issue:* Study on the Cytoskeleton of Cultured Goat Temporomandibular Joint Disc Cells (山羊颞下颌关节盘细胞肌动蛋白骨架的研究) KONG Nan-nan, ZHANG Wen-xia, KANG Hong, BAO Guang-jie, Key Lab of Stomatology of State Ethnic Affairs Commission, Northwest University for Nationalities, School of Stomatology, Lanzhou University ...... page:953-956 Differential Expression of Candida Albicans ALS Gene Family During Biofilm Formation In Vitro (白色念珠菌ALS基因家族在生物膜形成过程中的差异表达) HE Miao, SONG Guang-tai, BIAN Zhuan, The State Key Laboratory Breeding Base of Basic... περισσότερα »
Percutaneous Endoscopic Gastrostomy and Open Gastrostomy
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
- Percutaneous Endoscopic Gastrostomy and Open GastrostomyReview Article - *Pages 165-168* - Lisa Lai, S. Fahd Ali - - First page PDF - Purchase PDF - $31.50 Percutaneous Endoscopic Gastrostomy and Open Gastrostomy Lisa Lai, MD , S. Fahd Ali, MD* Introduction Many patients with head and neck cancers have impaired swallowing, leading to either the inability to take nutrition and hydration orally or they have an unacceptable risk for aspiration. Without nutrition, most postoperative patients would fail to heal. When a feeding tube is required, early ga... περισσότερα »
Tube Thoracostomy
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
- Tube ThoracostomyReview Article - *Pages 151-157* - Paul B. McBeth, Stephanie A. Savage - - First page PDF - Purchase PDF - $31.50 Tube Thoracostomy Paul B. McBeth, MD, MASc, FRCSC , Stephanie A. Savage, MD, MS* Introduction The procedure of tube thoracostomy is the insertion of a tube into the pleural cavity to facilitate drainage of air and fluid. The purpose of this article is to highlight the role of tube thoracostomy in the management of surgical patients. A generalized approach and description of indications, contraindications, procedural ste... περισσότερα »
Percutaneous Dilatational Tracheostomy
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
- Percutaneous Dilatational TracheostomyReview Article - *Pages 125-129* - Lillian F. Liao, John G. Myers - - First page PDF - Purchase PDF - $31.50 Percutaneous Dilatational Tracheostomy Lillian F. Liao, MD, MPH a , John G. Myers, MD b, * Introduction Tracheostomy was first described by the Greeks some 4000 years ago. Tracheostomy was subsequently documented by the Roman and Arabic literature as a method of relieving airway obstruction.1e3 This procedure is now primarily performed for those patients requiring prolonged airway assistance for its ease... περισσότερα »
Open Tracheostomy Procedure
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
- Open Tracheostomy ProcedureReview Article - *Pages 117-124* - Christine B. Taylor, Randal A. Otto - - First page PDF - Purchase PDF - $31.50 - Supplementary content Open Tracheostomy Procedure Christine B. Taylor, MD , Randal A. Otto, MD* Video of a tracheostomy demonstration accompanies this article at http://www.oralmaxsurgeryatlas.theclinics.com/ Introduction: nature of the problem Tracheotomy1 remains an important method for managing the airway of patients in the acute setting as well as providing a safe airway for patients who cannot o... περισσότερα »
Surgically Assisted Maxillary Expansion
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
Surgically Assisted Maxillary Expansion via Atlas of the Oral and Maxillofacial Surgery Clinics Publication date: Available online 24 November 2015 *Source:*Atlas of the Oral and Maxillofacial Surgery Clinics Author(s): Norman J. Betts Surgically Assisted Maxillary Expansion Norman J. Betts, DDS, MS a,b,c, * Introduction: nature of the problem Complete and accurate evaluation of a patient with a dentofacial deformity must include assessment of the transverse dimension. Few practitioners adequately evaluate the transverse dimension, often resulting in undiagnosed transverse maxillomandib...περισσότερα »
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Sphenopalatine Artery Ligation for Epistaxis: Factors Influencing Outcome and Impact of Timing of Surgery: Objective Sphenopalatine artery ligation is a commonly employed surgical intervention for control of posterior epistaxis unresponsive to nasal packing. The objective of the present study was to evaluate the outcome of sphenopalatine artery ligation for control of epistaxis at our institution and the impact of timing and other factors on outcome. Study Design Case series with chart review. Setting Academic tertiary referral center. Subjects and Methods Case notes were review... περισσότερα »
Diagnostic accuracy of fractional exhaled nitric oxide (FENO)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Influence of the practice setting on diagnostic prediction rules using FENO measurement in combination with clinical signs and symptoms of asthma: Objectives To evaluate the influence of the practice setting on diagnostic accuracy of fractional exhaled nitric oxide (FENO) for diagnosing asthma; and to develop prediction rules for diagnostic decision-making including clinical signs and symptoms (CSS). Setting Patients from 10 general practices and 1 private practice of 5 pneumologists in ambulatory care. Participants 553 patients, 57.9% female. Consecutive inclusion of diagnostic-... περισσότερα »
EVerT2--needling versus non-surgical debridement for the treatment of verrucae: study protocol for a single-centre randomised controlled trial
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
EVerT2--needling versus non-surgical debridement for the treatment of verrucae: study protocol for a single-centre randomised controlled trial: Introduction Verrucae are extremely common, and are experienced by most people at some time during their lives. Although most verrucae will spontaneously disappear without treatment, many patients seek treatment, often because they have persisted for many years, are unsightly or painful or prevent them from doing sports or other activities. There are many different treatments available; including the Falknor's needling procedure. To date, t...περισσότερα »
What is living on your dog's skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
What is living on your dog's skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis: To characterize the skin-associated fungal microbiota (mycobiota) in dogs, and to evaluate the influence of body site, individual dog or health status on the distribution of fungi, next-generation sequencing was performed targeting the internal transcribed spacer region. A total of 10 dogs with no history of skin disease were sampled at 10 distinct body sites consisting of haired and mucosal skin, and 8 dogs with diagnosed skin allergies were sam... περισσότερα »
IgG4-related disease manifesting the gastric wall thickening
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
IgG4-related disease manifesting the gastric wall thickening: IgG4-related disease (IgG4-RD) is a recently designated disease entity and its full picture has not yet been elucidated. Here, we report an unusual case of a patient with gastric wall thickening secondary to IgG4-RD. A 68-year-old male visited our hospital with itchy skin lesions and an episode of organizing pneumonia. On the suspicion of malignancy-associated skin lesions, computed tomography (CT) was performed. The CT revealed prominent thickening of the gastric wall. Due to the possibility of malignancy, the patient u... περισσότερα »
Defects in the Fanconi anemia pathway in head and neck cancer cells stimulate tumor cell invasion through DNA-PK and Rac1 signaling
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Defects in the Fanconi anemia pathway in head and neck cancer cells stimulate tumor cell invasion through DNA-PK and Rac1 signaling: Purpose:Head and neck squamous cell carcinoma (HNSCC) remains a devastating disease, and FA gene mutations and transcriptional repression are common. Invasive tumor behaviour is associated with poor outcome, but relevant pathways triggering invasion are poorly understood. There is a significant need to improve our understanding of genetic pathways and molecular mechanisms driving advanced tumor phenotypes, in order to develop tailored therapies. Here ... περισσότερα »
GSK2126458, an Oral Pan-Class IPhosphatidylinositol-3-kinase inhibitor, in Patients with Advanced SolidTumor Malignancies
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
First-in-human Phase I Study of GSK2126458, an Oral Pan-Class IPhosphatidylinositol-3-kinase inhibitor, in Patients with Advanced SolidTumor Malignancies: Purpose: GSK2126458 (GSK458) is a potent inhibitor of PI3K (α, β, , ), with pre-clinical studies demonstrating broad anti-tumor activity. We performed a first-in-human phase 1 study in patients with advanced solid tumors. Experimental Design: Patients received oral GSK458 once or twice daily in a dose escalation design to define the maximally tolerated dose (MTD). Expansion cohorts evaluated pharmacodynamics (PD), pharmacokinetic...περισσότερα »
Apparative Therapie bei kombiniertem Hörverlust
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Apparative Therapie bei kombiniertem Hörverlust: Zusammenfassung HintergrundZur apparativen Hörrehabilitation von Patienten mit kombiniertem Hörverlust gibt es verschiedene Hörsysteme. Mit dem kürzlich eingeführten objektiven Vergleichskriterium „maximum output“ (maximaler Ausgangspegel, den ein Hörgerät leisten kann), ist es gut möglich, die Indikationsbereiche dieser Systeme abzuschätzen. Ziel der ArbeitDie für die Geräteauswahl wichtigen Begriffe wie Verstärkung („gain“), Dynamikbereich und maximaler Ausgangspegel werden systematisch eingeführt. Im experimentellen Teil werde... περισσότερα »
Serological, genomic, and structural analyses of the major mite allergen Der p 23
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Serological, genomic, and structural analyses of the major mite allergen Der p 23: Abstract Background Der p 23 was recently identified in a European population as a major allergen and potentially a chitin binding protein. Objective This study sought to assess the importance of Der p 23 among other *Dermatophagoides* allergens in a North American population, and to determine the structure for functional characterization. Methods IgE binding to Der p 23, Der p 1, Der p 2, Der p 5, Der p 7, and Der p 8 was measured by ELISA. RNA-seq data from *D. pteronyssinus* were compared as estima...περισσότερα »
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
Systemic Biomarkers in 2-Phase Antibiotic Periodontal Treatment: A Randomized Clinical Trial: Accumulating evidence suggests that periodontal infections may have an impact on systemic health. In patients with untreated periodontitis, very high values for several inflammatory markers in serum are expressed simultaneously. We investigated to what extent these peak values change after nonsurgical and surgical periodontal treatment, with adjunctive antibiotics administered during the first or the second treatment phase. In a single-center, randomized, placebo-controlled, and double-mas... περισσότερα »
Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα
Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases: Chronic periodontitis (CP) is a prevalent pathogen-associated inflammatory disorder characterized by the destruction of tooth-supporting tissues, and linked to several systemic diseases. Both the periodontopathogen *Porphyromonas gingivalis* (*Pg*), and the genetically determined host immune response, are hypothesized to play a crucial role in this association. To identify new target genes for CP and its associated...περισσότερα »
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου