Head and Neck Medicine by Alexandros G.Sfakianakis: OtoRhinoLaryngology New Articles,November 9th,2015,a

Δευτέρα 9 Νοεμβρίου 2015

OtoRhinoLaryngology New Articles,November 9th,2015,a

Canalplasty for Exostoses With Maximal Skin Preservation With Temporoparietal Fascia Grafting and Use of Bone Wax for Skin Flap Protection: A Retrospective Case Series

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Canalplasty for Exostoses With Maximal Skin Preservation With Temporoparietal Fascia Grafting and Use of Bone Wax for Skin Flap Protection: A Retrospective Case Series: Background: External auditory canal exostoses are benign, bony overgrowths that arise in patients who experience chronic cold water exposure. While considerable advancement has been made in canalplasty techniques in recent decades, many patients continue to experience prolonged healing periods and recurrent stenosis following surgery. Objective: To perform a retrospective outcomes analysis of our experience with a ...περισσότερα »

Changing Patterns in Reflux Care: 10-Year Comparison of ABEA Members

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Changing Patterns in Reflux Care: 10-Year Comparison of ABEA Members: Objectives: To compare patterns of laryngopharyngeal reflux (LPR) diagnosis and management over time by American Broncho-Esophagological Association (ABEA) members. Methods: American Broncho-Esophagological Association members completed an online questionnaire focused on LPR evaluation and management in 2012; responses were compared to a 2002 survey. Results: Four hundred twenty-six members were emailed, of whom 63 (14.8%) responded. In both time periods, throat clearing, heartburn, globus, arytenoid edema, an... περισσότερα »

Pediatric Idiopathic Intracranial Hypertension Presenting With Sensorineural Hearing Loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Pediatric Idiopathic Intracranial Hypertension Presenting With Sensorineural Hearing Loss: Objective: To present the rare case of a young boy with idiopathic intracranial hypertension presenting with bilateral sensorineural hearing loss developing over several months. This was accompanied by headaches, otalgia, tinnitus, and vertigo. Furthermore, we aim to provide a concise review on this matter, as this report represents the second case in literature of pediatric idiopathic intracranial hypertension presenting with hearing loss. Methods: Workup of a 9-year-old boy with bilateral s... περισσότερα »

Bacterial Laryngotracheitis and Associated Upper Airway Obstruction: A Case Series

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Bacterial Laryngotracheitis and Associated Upper Airway Obstruction: A Case Series: Background: Iatrogenic laryngotracheal stenosis (LTS) continues to be a known complication of indwelling endotracheal tubes (ETTs). It is well established that secondary scar formation caused by inflammation and mucosal injury are the main mechanisms by which stenosis occurs. Additionally, there are reports of bacterial colonization of ETTs and its potential association with tracheal scar formation. We describe 4 cases of patients with history of intubation and/or tracheostomy and presumed LTS that ...περισσότερα »

Optimal Management of a 2-Hour-Old Newborn With Severe Congenital Subglottic Stenosis and Multiple Congenital Heart Diseases

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Optimal Management of a 2-Hour-Old Newborn With Severe Congenital Subglottic Stenosis and Multiple Congenital Heart Diseases: Introduction: Congenital subglottic stenosis (C-SGS) is the third most common congenital anomaly of the larynx. It necessitates tracheotomy in newborns if it causes severe airway obstruction. When the negative impact of tracheostomy cannot be tolerated, as in presence of congenital heart disease requiring further surgical intervention, other alternative procedures are required. This case report is the first of its kind reporting airway expansion in a neonate i... περισσότερα »

Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.: *Cytological accuracy and radiological staging in patients with thyroid cancer in Glasgow.* Eur Arch Otorhinolaryngol. 2015 Nov 7; Authors: Montgomery J, Hendry J, Van der Horst C, Hunter MA, MacKenzie K, Hilmi O Abstract To assess the accuracy of initial combined cytological accuracy and radiological staging of patients suspected of having thyroid malignancy with their final histopathology. Retrospective case series in a tertiary referral centre for head and neck malignancy. All patients ...περισσότερα »

Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.: *Management of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma.* Eur Arch Otorhinolaryngol. 2015 Nov 7; Authors: Arslanoğlu S, Eren E, Özkul Y, Ciğer E, Kopar A, Önal K, Etit D, Tütüncü GY Abstract The objective of this study was to determine the incidence of thyroid gland invasion in laryngeal and hypopharyngeal squamous cell carcinoma; and the association between clinicopathological parameters and thyroid gland invasion. Medical records of 75 patients w...περισσότερα »

Decrease of nasal airway resistance and alleviations of symptoms after balloon sinuplasty in patients with isolated chronic rhinosinusitis. A prospective, randomized clinical study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Decrease of nasal airway resistance and alleviations of symptoms after balloon sinuplasty in patients with isolated chronic rhinosinusitis. A prospective, randomized clinical study: Abstract Objectives The aim of the study is to evaluate and compare the clinical outcome of balloon sinuplasty and uncinectomy for patients suffering from isolated chronic rhinosinusitis of the maxillary sinus. Design A prospective, randomized*, non-blinded,* controlled trial was conducted. Setting The study was carried out at the Department of Otolaryngology, Tampere University Hospital, Finland. Partici...περισσότερα »

Human Respiratory Syncytial Virus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Recent Advances in Diagnosis, Prevention, and Treatment of Human Respiratory Syncytial Virus: Human respiratory syncytial virus (RSV) is a common cause of respiratory infection in infants and the elderly, leading to significant morbidity and mortality. The interdisciplinary fields, especially biotechnology and nanotechnology, have facilitated the development of modern detection systems for RSV. Many anti-RSV compounds like fusion inhibitors and RNAi molecules have been successful in laboratory and clinical trials. But, currently, there are no effective drugs for RSV infection even a...περισσότερα »

Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Screening of Viral Pathogens from Pediatric Ileal Tissue Samples after Vaccination: In 2010, researchers reported that the two US-licensed rotavirus vaccines contained DNA or DNA fragments from porcine circovirus (PCV). Although PCV, a common virus among pigs, is not thought to cause illness in humans, these findings raised several safety concerns. In this study, we sought to determine whether viruses, including PCV, could be detected in ileal tissue samples of children vaccinated with one of the two rotavirus vaccines. A broad spectrum, novel DNA detection technology, the Lawrence ...περισσότερα »

Influenza Virus Aerosols in the Air and Their Infectiousness

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Influenza Virus Aerosols in the Air and Their Infectiousness: Influenza is one of the most contagious and rapidly spreading infectious diseases and an important global cause of hospital admissions and mortality. There are some amounts of the virus in the air constantly. These amounts is generally not enough to cause disease in people, due to infection prevention by healthy immune systems. However, at a higher concentration of the airborne virus, the risk of human infection increases dramatically. Early detection of the threshold virus concentration is essential for prevention of the ... περισσότερα »

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation: Nelfinavir (NFV) is an HIV-1 aspartyl protease inhibitor that has numerous effects on human cells, which impart attractive antitumor properties. NFV has also been shown to have in vitro inhibitory activity against human herpesviruses (HHVs). Given the apparent absence of an aspartyl protease encoded by HHVs, we investigated the mechanism of action of NFV herpes simplex virus type 1 (HSV-1) in cultured cells. Selection of HSV-1 resistance to NFV was not achieved despite multiple ...περισσότερα »

Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period: Viral infections are one of the main causes of acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergence of A/H1N1pdm influenza virus in the 2009 pandemic changed the viral etiology of exacerbations that were reported before the pandemic. The aim of this study was to describe the etiology of respiratory viruses in 195 Spanish patients affected by AE-COPD from the pandemic until the 2011-12 influenza epidemic. During the study period (... περισσότερα »

Mixed Viral Infections Circulating in Hospitalized Patients with Respiratory Tract Infections

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Mixed Viral Infections Circulating in Hospitalized Patients with Respiratory Tract Infections in Kuwait: The aim of this study was to determine the frequency of viral mixed detection in hospitalized patients with respiratory tract infections and to evaluate the correlation between viral mixed detection and clinical severity. Hospitalized patients with respiratory tract infections (RTI) were investigated for 15 respiratory viruses by using sensitive molecular techniques. In total, 850 hospitalized patients aged between 3 days and 80 years were screened from September 2010 to April 20... περισσότερα »

Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis: Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without... περισσότερα »

Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis: Subacute Sclerosing Panencephalitis (SSPE), a rare lethal disease of children and young adults due to persistence of measles virus (MeV) in the brain, is caused by wild type (wt) MeV. Why MeV vaccine strains never cause SSPE is completely unknown. Hypothesizing that this phenotypic difference could potentially be represented by a molecular marker, we compared glycoprotein and matrix (M) genes from SSPE cases with those from the Moraten vaccine stra...περισσότερα »

A Stinging Sensation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

A Stinging Sensation: Approximately 10 minutes after being stung on the right lower leg by a yellow jacket (a type of wasp), a 45-year-old man began to feel light-headed and nauseated. He called emergency medical services, and paramedics arrived 10 minutes later. They found him to be alert but anxious, with scattered… Case Approximately 10 minutes after being stung on the right lower leg by a yellow jacket (a type of wasp), a 45-year-old man began to feel light-headed and nauseated. He called emergency medical services, and paramedics arrived 10 minutes later. They found him to be ... περισσότερα »

Mast Cells, Mastocytosis, and Related Disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Mast Cells, Mastocytosis, and Related Disorders: Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. Dr. Theoharides reports receiving royalties from a patent (US 8,268,365 B2) related to an antiinflammatory composition for treating brain inflammation, licensed to Algonot (a portion of the proceeds is given to Tufts University under an agreement and another portion is given to to AutismFreeBrain, a nonprofit company for autism research). He also reports holding a patent (US 7,906,153 B2) related to mast cells, antiinflammatory ag... περισσότερα »

Coral Dermatitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Coral Dermatitis: A 31-year-old man presented with a 1-week history of pruritic rash on his left foot, which developed after he brushed against coral while snorkeling in the Caribbean Sea. After contact with the coral, he reported the onset of a burning sensation in the foot, which was followed 1 hour later by the development of an intensely pruritic rash. The physical examination revealed an erythematous, cerebriform plaque on the lateral aspect of the left foot. On the basis of the patient’s history and cutaneous findings, a diagnosis of coral dermatitis was made. Coral dermat... περισσότερα »

Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα

Anti–PD-1–Related Pneumonitis during Cancer Immunotherapy: To the Editor: The use of antibodies against programmed cell death 1 (PD-1), which block inhibitory T-cell checkpoints, is a promising new therapy for advanced cancers. Recent trials have shown substantial clinical activity of anti–PD-1 antibodies in advanced cancers and led to the approvals of…

Thymoma, Diarrhea, and Weight Loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Case 31-2015: A 29-Year-Old Man with Thymoma, Diarrhea, and Weight Loss: Presentation of Case. Dr. Kimberly G. Blumenthal (Medicine): A 29-year-old man with metastatic thymoma was seen in the outpatient oncology clinic of this hospital because of intractable diarrhea of 1 month’s duration. The patient had received a diagnosis of thymoma at another hospital 5 years…

Mediastinal sarcoidosis diagnosed by endobronchial ultrasound in a patient with Sjögren's syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Mediastinal sarcoidosis diagnosed by endobronchial ultrasound in a patient with Sjögren's syndrome: *Augusto Carbonari, Marco Camunha, Fabio Marioni, Mauro Saieg, Lucio Rossini* *Endoscopic Ultrasound 2015 4(3):268-269* *A 51-year-old woman with dyspnea, cough, and fever for the preceding 6 months was referred for endobronchial ultrasound (EBUS) to evaluate mediastinal lymphadenopathy. The patient had a history of Sjögren's syndrome. Conventional chest X-ray demonstrated hilar lymphadenopathy [Figure 1]. Computed tomography examination revealed calcified mediastinal lymph nodes i... περισσότερα »

Starry sky sign: A prevalent sonographic finding in mediastinal tuberculous lymph nodes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Starry sky sign: A prevalent sonographic finding in mediastinal tuberculous lymph nodes: *Ibrahim Onur Alici, Nilgün Yilmaz Demirci, Aydin Yilmaz, Jale Karakaya, Yurdanur Erdogan* Endoscopic Ultrasound 2015 4(3):225-228 Background and Objectives: We report a prevalent finding in tuberculous lymphadenitis (TL): Starry sky sign, hyperechoic foci without acoustic shadows over a hypoechoic background. Materials and Methods: We retrospectively searched the database for a possible relationship of starry sky sign with a specific diagnosis and also the prevalence and accuracy of the fi...περισσότερα »

Endoscopic ultrasound: Elastographic lymph node evaluation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα

Endoscopic ultrasound: Elastographic lymph node evaluation: *Christoph F Dietrich, Christian Jenssen, Paolo G Arcidiacono, Xin-Wu Cui, Marc Giovannini, Michael Hocke, Julio Iglesias-Garcia, Adrian Saftoiu, Siyu Sun, Liliana Chiorean* Endoscopic Ultrasound 2015 4(3):176-190 Different imaging techniques can bring different information which will contribute to the final diagnosis and further management of the patients. Even from the time of Hippocrates, palpation has been used in order to detect and characterize a body mass. The so-called virtual palpation has now become a reality... περισσότερα »

Der MKG-Chirurg, Vol. 8, Issue 4 - New Issue Alert

Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα

If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 11/09/2015 Dear Reader, We are pleased to deliver your requested table of contents alert for *Der MKG-Chirurg*. Volume 8 Number 4 is now available online. Important news Papers, the reference manager, for iPhone and iPad now totally free Full functionality, no in-app purchases or small print. Find, organize, read and share the research materials you care about, anytime, anywhere. Download today: http://papersapp.com/ios. » Learn more In this issue Einführung zum ... περισσότερα »

The preferred chewing side

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα

Journal of Oral Rehabilitation Peripheral, functional and postural asymmetries related to the preferred chewing side in adults with natural dentition B. Rovira-lastra, E. I. Flores-orozco, R. Ayuso-montero, M. Peraire, J. Martinez-gomis ·Monday, November 09, 2015, 15:42 Summary The aim of this cross-sectional study was to determine the preferred chewing side and whether chewing side preference is related to peripheral, functional or postural lateral preferences. One hundred and forty-six adults with natural dentition performed three masticatory assays, each consisting of five trials o... περισσότερα »

Melkersson-Rosenthal Syndrome with Orofacial Swelling and Recurrent Lower Motor Neuron Facial Nerve Palsy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα

Case Reports in Otolaryngology : A Case Report and Review of the Literature Jerome Okudo And Yemi Oluyide · Monday, November 09, 2015, 16:02 Melkersson-Rosenthal Syndrome (MRS) is a rare otoneurologic condition, which is poorly understood and often underdiagnosed. Etiology and incidence are unclear, although infectious, inflammatory, and genetic causes have been implicated. Recurrent facial nerve palsy, facial swelling, and fissured tongue are the symptoms and signs of this condition. However, this triad is not typical in all patients as patients may present with one or more of the sy...περισσότερα »

A Strategy for Enhanced Antibacterial Activity against Staphylococus aureus by Assembly of Alamethicin with Thermo-Sensitive Polymeric Carrier

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα

A Strategy for Enhanced Antibacterial Activity against Staphylococus aureus by Assembly of Alamethicin with Thermo-Sensitive Polymeric Carrier: [image: CrossMark.jpg] *Chem. Commun.*, 2015, Accepted Manuscript *DOI*: 10.1039/C5CC07054F, Communication Ping Dong, Yuan Zhou, Weiwei He, Daoben Hua We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by assembly of antimicrobial peptides with temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells... The content of this RSS Feed (c) The Royal Society of Chemis... περισσότερα »

Case report of 49-year-old man with unusual invasive thymoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα

Case report of 49-year-old man with unusual invasive thymoma: 2015-11-09T06-46-29Z *Source:* International Journal of Medical Science and Public Health Osama Abdalla Mabrouk Kheiralla. Invasive thymomas are rare anterior mediastinal tumor, representing 50% of anterior mediastinal masses and about 20%30% of all mediastinal tumors. They are of unknown etiology; about 50% of patients with thymomas are diagnosed incidentally with chest radiography. Thymoma is classified into different stages, which determine the prognosis and type of management, the standard primary treatment for thes...περισσότερα »

Terbinafine-induced acute generalized exanthematous pustulosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα

Terbinafine-induced acute generalized exanthematous pustulosis στο ScopeMed - RSS 2015-11-09T06-46-29Z *Source:* International Journal of Medical Science and Public Health Sharadashri Rao, Kuladeepa Ananda Vaidya, Manjunath Hulmani. Acute generalized exanthematous pustulosis (AGEP) is a diffuse pustular disorder, a member of the neutrophilic dermatoses. Histologically, it is represented by the presence of vasculitis, linked with nonfollicular subcorneal pustules. Majority of cases is related to medication administration. In this article, we are reporting a case of AGEP caused by terbin...περισσότερα »

Terbinafine-induced acute generalized exanthematous pustulosis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 45 δευτερόλεπτα

Terbinafine-induced acute generalized exanthematous pustulosis: 2015-11-09T06-46-29Z *Source:* International Journal of Medical Science and Public Health Sharadashri Rao, Kuladeepa Ananda Vaidya, Manjunath Hulmani. Acute generalized exanthematous pustulosis (AGEP) is a diffuse pustular disorder, a member of the neutrophilic dermatoses. Histologically, it is represented by the presence of vasculitis, linked with nonfollicular subcorneal pustules. Majority of cases is related to medication administration. In this article, we are reporting a case of AGEP caused by terbinafine, an ant... περισσότερα »

Periodontal probing depth and attachment levels

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 46 δευτερόλεπτα

Comparative evaluation of accuracy of periodontal probing depth and attachment levels using a Florida probe versus traditional probes στο ScienceDirect Publication: Medical Journal Armed Forces India Publication date: October 2015 *Source:*Medical Journal Armed Forces India, Volume 71, Issue 4 Author(s): Nitin Gupta, S.K. Rath, Parul Lohra BackgroundThe current interest in the assessment of Clinical attachment level (CAL) has stimulated recent introduction of novel periodontal probes. CAL is currently the gold standard for diagnosis and monitoring of periodontal disease. The errors inhe... περισσότερα »

Objective criteria for diagnosing high altitude pulmonary edema

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 49 δευτερόλεπτα

in acclimatized patients at altitudes between 2700m and 3500m στο ScienceDirect Publication: Medical Journal Armed Forces India Publication date: October 2015 *Source:*Medical Journal Armed Forces India, Volume 71, Issue 4 Author(s): Anuj Chawla, K.K. Tripathi BackgroundThe criteria used for diagnosing high altitude illnesses are largely based on Western literature. This study was undertaken to define objective, simple and reliable diagnostic criteria for high altitude pulmonary edema (HAPE) in Indian soldiers at altitudes between 2700m and 3500m.MethodsClinical data of 235 cases of HA...περισσότερα »

Accelerated degradation of collagen membranes in diabets is associated with increased infiltration of macrophages and blood vessels

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Accelerated degradation of collagen membranes in diabetic rats is associated with increased infiltration of macrophages and blood vessels στο Latest Results for Clinical/ /Oral/ /Investigations AbstractObjectivesIncreased collagenolytic activity in diabetes may compromise collagen membrane (CM) survival. Tetracycline (TTC) possesses anti-collagenolytic properties and delays CM degradation. This study evaluated macrophage and capillary infiltration within CMs in diabetic rats. Materials and methodsDiabetes was induced in 20 Wistar rats by streptozotocin and 20 served as controls. Biotin... περισσότερα »

Temporomandibular Disorders and Chronic Fatigue Syndrome

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

A systematic review of the comorbidity between από L. J. Robinson, J. Durham, J. L. Newton στο Journal of Oral Rehabilitation Summary The most common cause of chronic oro-facial pain is a group of disorders collectively termed temporomandibular disorders (TMDs). Chronic painful TMD is thought to be a ‘central sensitivity syndrome’ related to hypersensitivity of the nervous system, but the cause is unknown. A similar understanding is proposed for other unexplained conditions, including chronic fatigue syndrome (CFS). Exploring the comorbidity of the two conditions is a valuable first...περισσότερα »

Peripheral, functional and postural asymmetries related to the preferred chewing side in adults with natural dentition

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα

Peripheral, functional and postural asymmetries related to the preferred chewing side in adults with natural dentition: Summary The aim of this cross-sectional study was to determine the preferred chewing side and whether chewing side preference is related to peripheral, functional or postural lateral preferences. One hundred and forty-six adults with natural dentition performed three masticatory assays, each consisting of five trials of chewing three pieces of silicon placed into a latex bag for 20 cycles, either freestyle or unilaterally on the right- or left-hand side. Occlusal ... περισσότερα »

Locators versus magnetic attachment effect on peri-implant tissue health of immediate loaded two implants retaining a mandibular overdenture: a 1-year randomised trial

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 53 δευτερόλεπτα

Locators versus magnetic attachment effect on peri-implant tissue health of immediate loaded two implants retaining a mandibular overdenture: a 1-year randomised trial: Summary This study aimed to evaluate peri-implant tissue health of immediate loaded two implants retaining a mandibular overdenture with either magnetic or locator attachment. Thirty two completely edentulous patients (20 males/12 females) were randomly assigned into two groups. Each patient received two implants in the canine area of the mandible using flapless surgical technique. Mandibular overdentures were immed...περισσότερα »

Association between sign language phonological awareness and word reading

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

Evidence of an association between sign language phonological awareness and word reading in deaf and hard-of-hearing children στο ScienceDirect Publication: Research in Developmental Disabilities Publication date: January 2016 *Source:*Research in Developmental Disabilities, Volume 48 Author(s): Emil Holmer, Mikael Heimann, Mary Rudner Background and aimsChildren with good phonological awareness (PA) are often good word readers. Here, we asked whether Swedish deaf and hard-of-hearing (DHH) children who are more aware of the phonology of Swedish Sign Language, a language with no orthogra...περισσότερα »

Early communicative behaviors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα

and their relationship to motor skills in extremely preterm infants στο ScienceDirect Publication: Research in Developmental Disabilities Publication date: January 2016 *Source:*Research in Developmental Disabilities, Volume 48 Author(s): Erika Benassi, Silvia Savini, Jana M. Iverson, Annalisa Guarini, Maria Cristina Caselli, Rosina Alessandroni, Giacomo Faldella, Alessandra Sansavini Despite the predictive value of early spontaneous communication for identifying risk for later language concerns, very little research has focused on these behaviors in extremely low-gestational-age infan... περισσότερα »

Children and those with Developmental Coordination Disorder (DCD)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα

Children with developmental coordination disorder demonstrate a spatial mismatch when estimating coincident-timing ability with tools στο ScienceDirect Publication: Research in Developmental Disabilities Publication date: January 2016 *Source:*Research in Developmental Disabilities, Volume 48 Author(s): Priscila Caçola, Melvin Ibana, Mark Ricard, Carl Gabbard Coincident timing or interception ability can be defined as the capacity to precisely time sensory input and motor output. This study compared accuracy of typically developing (TD) children and those with Developmental Coordination...περισσότερα »

Chronic pain therapy: an evolution from solo-interventions to a holistic interdisciplinary patient approach

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα

Chronic pain therapy: an evolution from solo-interventions to a holistic interdisciplinary patient approach: The treatment of chronic pain patients has changed over years. Anaesthesiologists treat pain patients, their skills in locoregional anaesthesia techniques and their pharmacological knowledge being a unique resource to reduce pain. However, the International Association for the Study of Pain provides more and more scientific evidence that chronic pain is a biopsychosocial event and that its diagnosis and treatment should be considered in a multidisciplinary frame. Nevertheles... περισσότερα »

Tau Immunotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα

Tau Immunotherapy: In recent years, tau immunotherapy has advanced from proof-of-concept studies [Sigurdsson EM, NIH R01AG020197, 2001; Asuni AA, et al: J Neurosci 2007;27:9115-9129], which have now been confirmed and extended by us and others. Phase I clinical trials on active and passive tau immunizations are being conducted, with several additional passive tau antibody trials likely to be initiated in the near future for Alzheimer's disease and other tauopathies. Because tau pathology correlates better with the degree of dementia than amyloid-β (Aβ) pathology, greater clinical ef... περισσότερα »

Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Genetic Disorders with Tau Pathology: A Review of the Literature and Report of Two Patients with Tauopathy and Positive Family Histories: *Background:* Tauopathies are a group of neurodegenerative disorders characterized by the pathological accumulation of hyperphosphorylated and insoluble tau protein within neurons and glia. Although most cases are sporadic, hereditary tauopathies have also been reported. *Summary:* In this article, we review genetic disorders in which tau pathology has been reported and present two novel families with primary tauopathies. Mutations in the microtub...περισσότερα »

Chronic Stress and Alzheimer's Disease

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Tau as the Converging Protein between Chronic Stress and Alzheimer's Disease Synaptic Pathology στο NDD : Last 10 articles *Background:* Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with a complex physiopathology and still undefined initiators. Several risk factors have been suggested for AD with recent evidence supporting an etiopathogenic role of chronic environmental stress and glucocorticoids (GCs, stress hormones) in the development of the disease. Indeed, both AD and chronic stress are associated with neuronal atrophy, synaptic loss and cognitive impa... περισσότερα »

Higher Frequency and Complexity of Sleep Disturbances in Dementia with Lewy Bodies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

as Compared to Alzheimer's Disease στο NDD : Last 10 articles *Background:* Sleep disturbances (SDs) are common in patients with all forms of dementia. However, most studies focus on Alzheimer's disease (AD) and less is known about the prevalence and characteristics of SD in dementia with Lewy bodies (DLB). *Objective:* The aims of this cross-sectional study were: (1) to examine the frequency of SD in DLB versus AD; (2) to compare patients with and without SD with regard to relevant clinical variables, and (3) to investigate the associations between SD and medication use. *Methods:*...περισσότερα »

AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin* Journal of Investigative Dermatology 135, 2732 (November 2015). doi:10.1038/jid.2015.282 Authors: Geneviève Garcin, Isabelle Guiraud, Matthieu Lacroix, Clémence Genthon, Stéphanie Rialle, Jean-Marie Joujoux, Laurent Meunier, Thierry Lavabre-Bertrand, Pierre-Emmanuel Stoebner & Lionel Le Gallic from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XZlWIw via IFTTT

A Deep-Intronic FERMT1 Mutation Causes Kindler Syndrome: An Explanation for Genetically Unsolved Cases

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*A Deep-Intronic FERMT1 Mutation Causes Kindler Syndrome: An Explanation for Genetically Unsolved Cases* Journal of Investigative Dermatology 135, 2876 (November 2015). doi:10.1038/jid.2015.227 Authors: Nadja Chmel, Sorina Danescu, Amelie Gruler, Dimitra Kiritsi, Leena Bruckner-Tuderman, Alexander Kreuter, Jürgen Kohlhase & Cristina Has from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1lfoDro via IFTTT

Clinical Snippets

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*Clinical Snippets* Journal of Investigative Dermatology 135, 2557 (November 2015). doi:10.1038/jid.2015.340 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XZlTMV via IFTTT

Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients* Journal of Investigative Dermatology 135, 2814 (November 2015). doi:10.1038/jid.2015.223 Authors: Hideki Mochizuki, Alexandru D P Papoiu, Leigh A Nattkemper, Andrew C Lin, Robert A Kraft, Robert C Coghill & Gil Yosipovitch from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XZlWbF via IFTTT

BJD Editor's Choice

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*BJD Editor's Choice* Journal of Investigative Dermatology 135, 2558 (November 2015). doi:10.1038/jid.2015.341 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1lfoCUn via IFTTT

Cell Surface CD74–MIF Interactions Drive Melanoma Survival in Response to Interferon-γ

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*Cell Surface CD74–MIF Interactions Drive Melanoma Survival in Response to Interferon-γ* Journal of Investigative Dermatology 135, 2901 (November 2015). doi:10.1038/jid.2015.259 Authors: Keiji Tanese, Yuuri Hashimoto, Zuzana Berkova, Yuling Wang, Felipe Samaniego, Jeffrey E Lee, Suhendan Ekmekcioglu & Elizabeth A Grimm from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XZlTfT via IFTTT

Editors' Picks

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα

*Editors' Picks* Journal of Investigative Dermatology 135, 2559 (November 2015). doi:10.1038/jid.2015.342 from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1XZlSsv via IFTTT

Hypohydration and Human Performance: Impact of Environment and Physiological Mechanisms

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Body water losses of >2 % of body mass are defined as hypohydration and can occur from sweat loss and/or diuresis from both cold and altitude exposure. Hypohydration elicits intracellular and extracellular water loss proportionate to water and solute deficits. Iso-osmotic hypovolemia (from cold and high-altitude exposure) results in greater plasma loss for a given water deficit than hypertonic hypovolemia from sweat loss. Hypohydration does not impair submaximal intensity aerobic performance in cold–cool environments, sometimes impairs aerobic performance in temperate env... περισσότερα »

Weight Management for Athletes and Active Individuals: A Brief Review

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Weight management for athletes and active individuals is unique because of their high daily energy expenditure; thus, the emphasis is usually placed on changing the diet side of the energy balance equation. When dieting for weight loss, active individuals also want to preserve lean tissue, which means that energy restriction cannot be too severe or lean tissue is lost. First, this brief review addresses the issues of weight management in athletes and active individuals and factors to consider when determining a weight-loss goal. Second, the concept of dynamic energy balanc... περισσότερα »

Resisted Sled Sprint Training to Improve Sprint Performance: A Systematic Review

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Background Based on recent findings regarding the mechanical determinants of sprint performance, resisted sled sprint (RSS) training may provide an effective tool for the improvement of sprint acceleration and maximal velocity. However, the volume and intensity for effective RSS training in different populations is unclear. Objectives The primary objective was to evaluate the effectiveness of RSS training compared with unresisted sprint (URS) training, and the differential effects of sled load on RSS training outcomes. Data Sources: Study Eligibility and Appraisal A sys... περισσότερα »

Re-Examining High-Fat Diets for Sports Performance: Did We Call the ‘Nail in the Coffin’ Too Soon?

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract During the period 1985–2005, studies examined the proposal that adaptation to a low-carbohydrate (<25 % energy), high-fat (>60 % energy) diet (LCHF) to increase muscle fat utilization during exercise could enhance performance in trained individuals by reducing reliance on muscle glycogen. As little as 5 days of training with LCHF retools the muscle to enhance fat-burning capacity with robust changes that persist despite acute strategies to restore carbohydrate availability (e.g., glycogen supercompensation, carbohydrate intake during exercise). Furthermore, a 2- to 3-week... περισσότερα »

Nutritional Support for Exercise-Induced Injuries

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Nutrition is one method to counter the negative impact of an exercise-induced injury. Deficiencies of energy, protein and other nutrients should be avoided. Claims for the effectiveness of many other nutrients following injuries are rampant, but the evidence is equivocal. The results of an exercise-induced injury may vary widely depending on the nature of the injury and severity. Injuries typically result in cessation, or at least a reduction, in participation in sport and decreased physical activity. Limb immobility may be necessary with some injuries, contributing to re... περισσότερα »

Carbohydrate Nutrition and Team Sport Performance

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract The common pattern of play in 'team sports' is 'stop and go', i.e. where players perform repeated bouts of brief high-intensity exercise punctuated by lower intensity activity. Sprints are generally 2–4 s long and recovery between sprints is of variable length. Energy production during brief sprints is derived from the degradation of intra-muscular phosphocreatine and glycogen (anaerobic metabolism). Prolonged periods of multiple sprints drain muscle glycogen stores, leading to a decrease in power output and a reduction in general work rate during training and competition.... περισσότερα »

Cytokines as Mediators of Pain-Related Process in Breast Cancer

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Pain is a clinical sign of inflammation found in a wide variety of chronic pathologies, including cancer. The occurrence of pain in patients carrying breast tumors is reported and is associated with aspects concerning disease spreading, treatment, and surgical intervention. The persistence of pain in patients submitted to breast surgery is estimated in a range from 21% to 55% and may affect patients before and after surgery. Beyond the physical compression exerted by the metastatic mass expansion and tissue injury found in breast cancer, inflammatory components that are significant... περισσότερα »

Experimental Spinal Stenosis in Cats: New Insight in Mechanisms of Hydrocephalus Development

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Abstract In our new experimental model of cervical stenosis without inflammation we have tested hypothesis that cranio-spinal communication impairment could lead to hydrocephalus development. Spinal and cranial cerebrospinal fluid (CSF) space separation was obtained with positioning of plastic semi-ring in epidural space at C2 level in cats. Brain ventricles planimetry, and CSF pressure recording in lateral ventricle (LV) and lumbar subarachnoid space (LSS) were performed in acute and subchronic experiments. In all experiments opening CSF pressures were normal. However, in acute e...περισσότερα »

Carbohydrate Dependence During Prolonged, Intense Endurance Exercise

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract A major goal of training to improve the performance of prolonged, continuous, endurance events lasting up to 3 h is to promote a range of physiological and metabolic adaptations that permit an athlete to work at both higher absolute and relative power outputs/speeds and delay the onset of fatigue (i.e., a decline in exercise intensity). To meet these goals, competitive endurance athletes undertake a prodigious volume of training, with a large proportion performed at intensities that are close to or faster than race pace and highly dependent on carbohydrate (CHO)-based fue... περισσότερα »

Nutritional Support for Athletic Performance

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1Nmn8hB via IFTTT

The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα

Abstract Energy substrates that are important to the working muscle at moderate intensities are the non-esterified fatty acids (NEFAs) taken up from the circulation and NEFAs originating from lipolysis of the intramuscular triacylglycerol (IMTAG). Moreover, NEFA from lipolysis via lipoprotein lipase (LPL) in the muscle of the very-low-density lipoproteins and in the (semi) post-prandial state chylomicrons may also contribute. In this review, the NEFA fluxes and oxidation by skeletal muscle during prolonged moderate-intensity exercise are described in terms of the integration of ph... περισσότερα »

Foods, Vol. 4, Pages 654-664: Comparison of R5 and G12 Antibody-Based ELISA Used for the Determination of the Gluten Content in Official Food Samples

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Celiac Disease (CD) is one of the most common food intolerances. It comes along with serious damage of the mucosa in the small intestine and is caused by the storage proteins—termed "gluten"—of wheat, rye, barley and possibly oats. Sensitive individuals need to stick to a strict gluten-free diet. The gluten level in food products labeled as "gluten-free", must not exceed 20 mg/kg. It is obvious that effective test methods are needed to accurately determine the gluten concentration in foods. The determination of the presence of gluten in foodstuffs is mainly done by means of an imm... περισσότερα »

Entropy, Vol. 17, Pages 7645-7657: Quantum Game Beats Classical Odds—Thermodynamics Implications

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

A quantum game is described making use of coins embodied as entangled Fermions in a potential energy well. It is shown that the odds are affected by the Pauli Exclusion Principle. They depend on the elevation in the energy well where the coins are selected, ranging from being a certainty of winning at the bottom of the well to being near classical at the top. These odds differ markedly from those in a classical game in which they are independent of elevation. The thermodynamics counterpart of the quantum game is discussed. It is shown that the temperature of a Maxwellian gas colum... περισσότερα »

Brain Sciences, Vol. 5, Pages 509-520: Emotional Meta-Memories: A Review

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Emotional meta-memory can be defined as the knowledge people have about the strategies and monitoring processes that they can use to remember their emotionally charged memories. Although meta-memory per se has been studied in many cognitive laboratories for many years, fewer studies have explicitly focused on meta-memory for emotionally charged or valenced information. In this brief review, we analyzed a series of behavioral and neuroimaging studies that used different meta-memory tasks with valenced information in order to foster new research in this direction, especially in term...περισσότερα »

Systematic revision of the adeleid haemogregarines, with creation of Bartazoon n. g., reassignment of Hepatozoon argantis Garnham, 1954 to Hemolivia, and molecular data on Hemolivia stellata

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Authors: Grégory Karadjian, Jean-Marc Chavatte and Irène Landau.<br>Parasite Vol. 22 , page 31<br>Published online: 09/11/2015<br> Keywords: Hepatozoon ; Bartazoon ; Hemolivia ; Karyolysus ; Life cycle ; Systematics revision ; Molecular data.<img src="http://ift.tt/20GEorJ" height="1" width="1" alt=""> from #Medicine via ola Kala on Inoreader http://ift.tt/1kFJMdE via IFTTT

Immunosuppressive phenolic compounds from Hydnora abyssinica A. Braun

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Background: Hydnora abyssinica (HA) A. Braun is an endemic Sudanese medicinal plant traditionally used as anti-inflammatory and against many infectious diseases. However, it proved to be very rich in phenols and tannins, so the present study was undertaken to investigate the immunomodulatory potential of the whole plant ethanolic extract and its isolated compounds. Methods: Lymphocyte proliferation, chemiluminescence and superoxide reduction assays were used for immunomodulatory evaluation. While, MTT (3–(4, 5-dimethylthazol-2-yl)-2, 5-diphenyl tetrazonium bromide) test was perfor... περισσότερα »

The Ameliorating Effect of Myrrh on Scopolamine-Induced Memory Impairments in Mice

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Myrrh has been used since ancient times for the treatment of various diseases such as inflammatory diseases, gynecological diseases, and hemiplegia. In the present study, we investigated the effects of aqueous extracts of myrrh resin (AEM) on scopolamine-induced memory impairments in mice. AEM was estimated with (2E,5E)-6-hydroxy-2,6-dimethylhepta-2,4-dienal as a representative constituent by HPLC. The oral administration of AEM for 7 days significantly reversed scopolamine-induced reduction of spontaneous alternation in the -maze test. In the passive avoidance task, AEM also rest... περισσότερα »

Healthcare, Vol. 3, Pages 1097-1120: Vitamin D and Reproduction: From Gametes to Childhood

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Vitamin D is well recognized for its essentiality in maintaining skeletal health. Recent research has suggested that vitamin D may exert a broad range of roles throughout the human life cycle starting from reproduction to adult chronic disease risk. Rates of vitamin D deficiency during pregnancy remain high worldwide. Vitamin D deficiency has been associated with an increased risk of fertility problems, preeclampsia, gestational diabetes, and allergic disease in the offspring. Vitamin D is found naturally in only a few foods thus supplementation can provide an accessible and effec... περισσότερα »

Catalysts, Vol. 5, Pages 1862-1871: Synthesis, Characterization and Catalytic Polymerization of N-Methyl Imidazolium Phosphotungstic Catalyst

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

N-methyl imidazolium phosphotungstic salt has been synthesized and used as a special catalyst for photopolymerization of vinyl monomers. This is a fast and smooth reaction, and high molecular weight polymers with narrow polydispersity are obtained within 60 min. The compound was structurally characterized by elemental analysis, IR spectroscopy, and 1H NMR spectroscopy. The electrochemical property is determined on a CHI 660 electrochemistry workstation. The polymerization initiated by N-methyl imidazolium phosphotungstic salt showed controlling characteristics, the catalyst can be...περισσότερα »

Biomolecules, Vol. 5, Pages 3029-3050: RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown. In one of these, an external guide sequence, which mimics a tRNA precursor, a well-known natural RNase P substrate, is used to target an RNA molecule for cleavage by endogenous RNase P. Alternatively, a guide sequence can be attached to M1 RNA, the (catalytic) RNase P RNA subunit of Escherichia coli. The guide sequence is specific for an RNA...περισσότερα »

Healthcare, Vol. 3, Pages 1086-1096: Family History of Sudden Cardiac Death of the Young: Prevalence and Associated Factors

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Sudden cardiac death of the young (SCDY) is a devastating event for families and communities. Family history is a significant risk factor for this potentially preventable cause of death, however a complete and detailed family history is not commonly obtained during routine health maintenance visits. To estimate the proportion of adults with a family history of SCDY, the Michigan Department of Health and Human Services (MDHHS) Genomics Program included two questions within the 2007 Michigan Behavioral Risk Factor Survey (MiBRFS). Prevalence estimates and 95% confidence intervals we...περισσότερα »

Biomedicines, Vol. 3, Pages 270-281: Circulating MicroRNAs as Biomarkers and Mediators of Cell–Cell Communication in Cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

The realization of personalized medicine for cancer will rely not only on the development of new therapies, but on biomarkers that direct these therapies to the right patient. MicroRNA expression profiles in the primary tumor have been shown to differ between cancer patients and healthy individuals, suggesting they might make useful biomarkers. However, examination of microRNA expression in the primary tumor requires an invasive biopsy procedure. More recently, microRNAs have been shown to be released from the primary tumor into the circulation where they can be utilized as non-in... περισσότερα »

JCM, Vol. 4, Pages 1908-1937: Renin-Angiotensin-Aldosterone System Blockade in Diabetic Nephropathy. Present Evidences

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Diabetic Kidney Disease (DKD) is the leading cause of chronic kidney disease in developed countries and its prevalence has increased dramatically in the past few decades. These patients are at an increased risk for premature death, cardiovascular disease, and other severe illnesses that result in frequent hospitalizations and increased health-care utilization. Although much progress has been made in slowing the progression of diabetic nephropathy, renal dysfunction and the development of end-stage renal disease remain major concerns in diabetes. Dysregulation of the renin-angioten...περισσότερα »

JLPEA, Vol. 5, Pages 234-256: Hardware-Efficient Delta Sigma-Based Digital Signal Processing Circuits for the Internet-of-Things

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

This paper presents hardware-efficient Delta Sigma linear processing circuits for the next generation low-power VLSI devices in the Internet-of-things (IoT).We first propose the P-N (positive-negative) pair method to manipulate both the analog value and length of a first-order Delta Sigma bit sequence. We then present a binary counter method. Based on these methods, we develop Delta Sigma domain on-the-fly digital signal-processing circuits: the Delta Sigma sum adder, average adder and coefficient multiplier. The counter-based average adder can work with both first-order and highe... περισσότερα »

Genes, Vol. 6, Pages 1183-1200: Super Enhancers in Cancers, Complex Disease, and Developmental Disorders

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες

Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. ... περισσότερα »