Our Clinical Approach to No. 12 Craniofacial Cleft Patient: Case Report
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 4 δευτερόλεπτα
Our Clinical Approach to No. 12 Craniofacial Cleft Patient: Case Report: 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Andaç Aykan, Serbülent Güzey, Fatih Zor, Doğan Alhan, Serdar Öztürk. Craniofacial clefts are rare congenital malformations of the facial region that can cause any of skin, soft tissue and bone disorders. Having 15 different variations and different clinical presentations in each group make the reconstructive period not to standardize through an algorithm. In this case report, our clinical approach that consisting of two-stages was presented to a Tessiers ... περισσότερα »
Evaluation of Safe Zones for Miniscrew Placement in Class II Patients with Different Vertical Skeletal Patterns
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 4 δευτερόλεπτα
Evaluation of Safe Zones for Miniscrew Placement in Class II Patients with Different Vertical Skeletal Patterns: 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Berkay Tolga SUER, Ersin YILDIRIM, Şeniz KARAÇAY, Mustafa ERKAN. The aim of this study was to compare interradicular space, buccolingual alveolar distance, and cortical bone thickness in skeletal Class II patients with long face and short face. The gender differences were also evaluated. 30 CBCT images obtained from patients with skeletal Class II malocclusion were divided into two groups according to patients facial...περισσότερα »
Craniofacial clefts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Our Clinical Approach to No. 12 Craniofacial Cleft Patient: Case Report στο ScopeMed - RSS 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Andaç Aykan, Serbülent Güzey, Fatih Zor, Doğan Alhan, Serdar Öztürk. Craniofacial clefts are rare congenital malformations of the facial region that can cause any of skin, soft tissue and bone disorders. Having 15 different variations and different clinical presentations in each group make the reconstructive period not to standardize through an algorithm. In this case report, our clinical approach that consisting of two-stages was presented t...περισσότερα »
The electrodiagnostic tests’ efficacy on prediction of early clinical prognosis of bell’s palsy : Nerve Excitability Test, Maximal Stimulation Test, Nerve Latency Test and Electromyography between 7th and 21th days of palsy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Comparison of στο ScopeMed - RSS 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Hasan Hüseyin Arslan, Üzeyir Yıldızoğlu, Bahtiyar Polat, Ömer Karakoç, Serdar Taşdemir. The aim of the study was to compare the prognostic value of the electrodiagnostic tests which have been used for prediction about prognosis of Bells palsy. 40 patients followed up at Gülhane Military Academy Otolaryngology Department between 2008 and 2011 because of Bells palsy were included in the study. Data were analyzed retrospectively. House-Brackmann classification was used for facial nerve functions. A...περισσότερα »
Comparison of dentofacial effect of the Eureka Spring and intermaxillary elastics in the treatment of Class II malocclusions
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 5 δευτερόλεπτα
Comparison of dentofacial effect of the Eureka Spring and intermaxillary elastics in the treatment of Class II malocclusions: 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Ersin Yıldırım, Şeniz Karaçay. The aim of this retrospective study was to evaluate the Eureka Spring (ES) appliance as a compliance-free alternative to intermaxillary elastics in the treatment of Class II malocclusions. The study was carried out with the measurements on pre- and post-treatment lateral cephalograms of 44 patients with Class II malocclusion who were treated with ES or intermaxillary elast... περισσότερα »
Oral hygiene and oral health status of the nursing students
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 5 δευτερόλεπτα
Oral hygiene and oral health status of the nursing students in Turkey: 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Mehmet Vehbi Bal, Umut Bengi, Cengizhan Açıkel, Işıl Saygun. In this study we aimed to determine oral hygiene behavior and oral health status of the students at the nursing school in Turkey, with a female student population representative of five different demographical regions of Turkey. Three hundred and twenty five female students (aged 18-22 years) of Gulhane Military Medical Academy, School of Nursing were included in the study. Intraoral examination w...περισσότερα »
Multidisiplinary Treatment of Non-Syndrome Oligodontia Patient
Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 6 δευτερόλεπτα
Multidisiplinary Treatment of Non-Syndrome Oligodontia Patient: 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Özlem Martı Akgün, Serkan Görgülü, Ceren Yıldırım. Dental anomalies are disturbances in tooth development determined by genetic and/or environmental factors and number, size, shape, structure and eruption of teeth should be affected. Many terms are available in the literature to describe a reduction in number of teeth: hypodontia, oligodontia, anodontia. Dental anomalies can be isolated or as a part of a syndrome or rarely it can be seen without any syndrome. It c... περισσότερα »
Occurrence and distribution of Malassezia species on skin and external ear canal of horses
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 7 δευτερόλεπτα
Summary The aim of this study was to investigate the prevalence of *Malassezia* species from the body skin and external ear canal of healthy horses. The samples were obtained by scraping the skin surface from the nose, groin and dorsum and swabbing from the external ear canal of 163 animals, and then incubated on sabouraud dextrose agar and modified Dixon agar. *Malassezia* species were isolated from 34.9% of horses. The percentages of *Malassezia* species were 64.3% for Arab, 35.7% for Persian, 35.4% for Thoroughbred and 27.1% for Turkmen breeds. The greatest abundance of *Malasse...περισσότερα »
Ascending aortic aneurysm caused by Mycobacterium tuberculosis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 7 δευτερόλεπτα
Background: Tuberculous aortitis is an unusual presentation of a common disease in Sri Lanka. There were no reported cases of tuberculous aortitis from Sri Lanka. Here we report a case of a 40-year-old woman who developed an ascending aortic aneurysm with severe aortic regurgitation caused by Mycobacterium tuberculosis.Case presentationA 40-year-old Sri Lankan female who presented with exertional breathlessness (NYHA II) and weight loss for 4 weeks duration was found to have collapsing pulse and early diastolic murmur at left sternal edge. Transthoracic and transesophageal echocar...περισσότερα »
Occurrence and distribution of Malassezia species on skin and external ear canal of horses
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 7 δευτερόλεπτα
Summary The aim of this study was to investigate the prevalence of *Malassezia* species from the body skin and external ear canal of healthy horses. The samples were obtained by scraping the skin surface from the nose, groin and dorsum and swabbing from the external ear canal of 163 animals, and then incubated on sabouraud dextrose agar and modified Dixon agar. *Malassezia* species were isolated from 34.9% of horses. The percentages of *Malassezia* species were 64.3% for Arab, 35.7% for Persian, 35.4% for Thoroughbred and 27.1% for Turkmen breeds. The greatest abundance of *Malasse...περισσότερα »
Prosthetic Rehabilitation of Midfacial Defect
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα
: A case report στο ScopeMed - RSS 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Arzu Atay, Cihan Cem Gürbüz, Yumuşhan Günay. ABSTRACT: Facial prostheses act as an alternative and supplement for the surgical reconstruction of the patients with facial defects. Rehabilitation of midfacial defects always been a complicated issue for maxillofacial prosthodontists. These midfacial defects lead to functional and cosmetic deficiencies. One of the causes of such defects is midline basal cell granüloma, which is a destructive granulomatous lesion of uncertain etiology, involving the n... περισσότερα »
Ascending aortic aneurysm caused by Mycobacterium tuberculosis
Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 9 δευτερόλεπτα
Background: Tuberculous aortitis is an unusual presentation of a common disease in Sri Lanka. There were no reported cases of tuberculous aortitis from Sri Lanka. Here we report a case of a 40-year-old woman who developed an ascending aortic aneurysm with severe aortic regurgitation caused by Mycobacterium tuberculosis.Case presentationA 40-year-old Sri Lankan female who presented with exertional breathlessness (NYHA II) and weight loss for 4 weeks duration was found to have collapsing pulse and early diastolic murmur at left sternal edge. Transthoracic and transesophageal echocar...περισσότερα »
Polysaccharide-based antibiofilm surfaces
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Polysaccharide-based antibiofilm surfaces στο Acta Biomaterialia Publication date: Available online 7 November 2015 *Source:*Acta Biomaterialia Author(s): Guy-Alain Junter, Pascal Thébault, Laurent Lebrun Surface treatment by natural or modified polysaccharide polymers is a promising means to fight against implant-associated biofilm infections. The present review focuses on polysaccharide-based coatings that have been proposed over the last ten years to impede biofilm formation on material surfaces exposed to bacterial contamination. Anti-adhesive and bactericidal coatings are consider... περισσότερα »
Engineering growth factors for regenerative medicine applications
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Engineering growth factors for regenerative medicine applications στο Acta Biomaterialia Publication date: Available online 7 November 2015 *Source:*Acta Biomaterialia Author(s): Aaron C. Mitchell, Priscilla S. Briquez, Jeffrey A. Hubbell, Jennifer R. Cochran Growth factors are important morphogenetic proteins that instruct cell behavior and guide tissue repair and renewal. Although their therapeutic potential holds great promise in regenerative medicine applications, translation of growth factors into clinical treatments has been hindered by limitations including poor protein stabilit... περισσότερα »
The prevalence of Malassezia species from the body skin and external ear canal
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
*Malassezia* From Wikipedia, the free encyclopedia *Malassezia*[image: Malassezia furfur in skin scale from a patient with tinea versicolor PHIL 3938 lores.jpg]*Malassezia furfur* in skin scale from a patient with tinea versicolorScientific classificationKingdom:Fungi Division:BasidiomycotaSubdivision:UstilaginomycotinaClass:Exobasidiomycetes Order:MalassezialesFamily:MalasseziaceaeGenus:*Malassezia*Species See text. *Malassezia* (formerly known as *Pityrosporum*) is a genus of fungi. *Malassezia* is naturally found on the skin surfaces of many animals, including humans. In occasional ...περισσότερα »
Restoration Of Single Tooth Loss With Fiber Reinforced Resin Bonded Composite
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
: Two Case Report στο ScopeMed - RSS 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Alper Akgürbüz, Zeynep Öncel Torun. As an alternative to the traditional restorations in single tooth loss, a more preventive, timesaving and economical method which is fiber reinforced adhesive bridge has been developed. Fiber reinforced composites (FRC) are metal free materials which have high mechanical and esthetic features. The advantages of these restorations are; low cost, less chair time, easy application and being non-allergic. In this clinical study, two case reports with single toot...περισσότερα »
Group C and G Streptococcus in pediatric acute tonsilopharyngitis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Prevalence of group C and G Streptococcus in pediatric acute tonsilopharyngitis in Turkey στο ScopeMed - RSS 2015-11-08T15-55-51Z *Source:* Gulhane Medical Journal Medine Ayşin Taşar, İlknur Bostancı, Esra Karakoç, Beray Selver, Mustafa Demirbilek, Yıldız Dallar. Our aim is determine the prevalence of group C and G streptococcus in acute tonsilopharyngitis in children. Of 200 children between 1-15 years of age with symptoms of acute tonsillopharyngitis were admitted to the study. All patients received throat culture sample were inoculated a 5% of blood agar. All of beta hemolytic stre... περισσότερα »
List of reported cases on various food items causing Oral allergy syndrome (OAS) symptoms
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
*S. numberFoodManifestationReference* ------------------------------ *1Jackfruit* *Itching and burning in the mouth and throat* *2Salami* *Mild pruritus in oral mucosa* *3Pork* *Itching and angioedema of the lips and oral mucosa* *4Honey* *Itching in the mouth, gastrointestinal symptoms, and angioedema* *5Tomato juice* *Dyspnea, swelling of the oral and nasal mucosa, and congestion of the bulbar conjunctiva* *6Raw fish* *Oropharyngeal irritation and facial angioedema* *7Peanut* *Lip tingling, oral itching, lip swelling, and throat itching* *8Cashew nut* *Sialorrhea, perioral urticar... περισσότερα »
Oral Allergy Syndrome
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
: An Update for Stomatologists στο Journal of Allergy *Oral allergy syndrome (OAS) is an allergic reaction in the oral cavity subsequent to the consumption of food such as fruits, nuts, and vegetables. It occurs mainly due to homology of proteins of pollen to the proteins of fruits and vegetables. In OAS, the immune system produces antibodies that are directed against the proteins of pollen and structurally similar proteins in food, hence, resulting in allergic symptoms limited mainly to the oral cavity. In this review, we have summarized the etiopathogenesis, clinical features, diag... περισσότερα »
Critical analysis of day time traffic noise level at curbside open-air microenvironment
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
of two types of road network of Kolkata City, India ενημερώθηκε στις 08:26 στο ScopeMed - RSS 2015-11-08T22-26-38Z *Source:* Journal of Environmental and Occupational Science Anirban Kundu Chowdhury, Anupam Debsarkar, Shibnath Chakrabarty. Aim: The aim of the research work is to critically analyze day time traffic noise level (Leq) at curbside open-air microenvironment of two types of road network of Kolkata City, India. Methods: 280 sets of data on road width, traffic volume, Leq, peak (L10) and background (L90) noise level were collected from curbsides of 23 major roads. The data was...περισσότερα »
Sleep impairment in patients with chronic rhinosinusitis (CRS)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 58 δευτερόλεπτα
Risk factors for sleep impairment in adult patients with chronic rhinosinusitis από Yuji Ando, Shintaro Chiba, Robson Capasso, Tetsushi Okushi, Hiromi Kojima, Nobuyoshi Otori, Kota Wada στο Auris Nasus Larynx Although sleep impairment is reported by patients with chronic rhinosinusitis, the associated factors have not been well studied. Therefore, we determined the associated risk factors for sleep impairment in patients with chronic rhinosinusitis (CRS). AbstractObjective Although sleep impairment is reported by patients with chronic rhinosinusitis, the associated factors have not be...περισσότερα »
Intractable Ménière's disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Surgical results and psychological status in patients with intractable Ménière's disease από Yoshihiro Yokota, Tadashi Kitahara, Masafumi Sakagami, Taeko Ito, Takahiro Kimura, Tadao Okayasu, Akinori Yamashita, Toshiaki Yamanaka στο Auris Nasus Larynx Mental disorder is often one of the causes to make treatments for Ménière's disease more difficult. The aim in the present study is to examine ratios of the neurosis and depression in patients with intractable Ménière's disease and also relationships between the ratios and surgical results after endolymphatic sac drainage with large dose...περισσότερα »
After-hours CT scanning services
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Audit of demand for after-hours CT scanning services in RANZCR-accredited training departments από Stacy K Goergen, Jane Grimm, Eldho Paul, Robert Fabiny, Wai Kit Lee, Steven Blome, Kim Zhou, Philip L Munro στο Journal of Medical Imaging and Radiation Oncology Abstract Introduction The aims of this study were to measure: (i) the growth in after-hours emergency department – referred CT (ED–CT) performed in accredited training departments between 2011 and 2013; (ii) the growth in ED CT relative to growth in ED presentations at the same hospitals; and (iii) trainee workload resulting fr...περισσότερα »
Trigeminal autonomic cephalalgias,SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing)
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
Familial SUNCT in mother and son από Martins, I. P., Viana, P., Lobo, P. P. στο Cephalalgia -- Preview Articles BackgroundTrigeminal autonomic cephalalgias comprise a heterogeneous group of lateralized headaches associated with ipsilateral autonomic symptoms. They are usually localized within the territory of one or more rami of the trigeminal nerve, but may be localized outside its cutaneous territory. Although these headaches are considered primary disorders, the evidence supporting their genetic nature is lacking, particularly concerning their neuralgic forms, with the exception o...περισσότερα »
General lack of use of placebo in prophylactic, randomised, controlled trials in adult migraine
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
. A systematic review από Hougaard, A., Tfelt-Hansen, P. στο Cephalalgia -- Preview Articles BackgroundThe Clinical Trials Subcommittee of the International Headache Society (IHS) recommends that a placebo arm is included in comparative randomised clinical trials (RCTs) of multiple prophylactic drugs due to the highly variable placebo response in migraine prophylaxis studies. The use of placebo control in such trials has not been systematically assessed. MethodsWe performed a systematic review of all comparative RCTs of prophylactic drug treatment of migraine published in English from ...περισσότερα »
Inflectional Verb Morphology in young children's speech
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 59 δευτερόλεπτα
An Elicited-Production Study of Inflectional Verb Morphology in Child Finnish από Sanna H. M. Räsänen, Ben Ambridge, Julian M. Pine στο Cognitive Science Abstract Many generativist accounts (e.g., Wexler, 1998) argue for very early knowledge of inflection on the basis of very low rates of person/number marking errors in young children's speech. However, studies of Spanish (Aguado-Orea & Pine, 2015) and Brazilian Portuguese (Rubino & Pine, 1998) have revealed that these low overall error rates actually hide important differences across the verb paradigm. The present study investigated ... περισσότερα »
Removing tumors from within the inner ear : NiLiBoRo from Fraunhofer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
NiLiBoRo from Fraunhofer από T. στο SurgRob [image: g_pi_Robotic%2Bworm%2Bfor%2Bhead%2Bsurge] Fraunhofer announced its new 5mm bending drilling robotic tool. You can check it out at the upcoming Medica fair. See the complete press release below. "Removing tumors from within the inner ear is a very delicate matter that typically requires surgeons to remove the entire mastoid bone. However, in the future, all doctors will need to do is cut a tunnel of 5 mm in diameter through the bone using a miniature robot named NiLiBoRo. The system is capable of adjusting its path while drillin...περισσότερα »
Auditory Brainstem Implants
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
20Q: - Continued Advancements for Both Adults and Children στο Audiology 1. Auditory Brainstem Implant? Isn’t that just another name for a special cochlear implant?No, not at all. Auditory brainstems implants (ABI) are actually are quite different. A cochlear implant (CI) is indicated for individuals with cochlear damage, either due to missing hair cells or a malformed cochlea, which results in a sensory loss. The internal component of the CI is comprised of an electrode array and a receiver stimulator. The array is threaded into the scala tympani of the cochlea, which takes advanta... περισσότερα »
Clinical Significance of Multinodularity in Patients with Papillary Thyroid Carcinoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- DAVOR KUST, - NEVEN MATEŠA, - and ZVONKO KUSIĆ 1. *Correspondence to:* Davor Kust, MD, Department of Oncology and Nuclear Medicine, University Hospital Centre “Sestre Milosrdnice”, Vinogradska cesta 29, 10000 Zagreb, Croatia. Tel: +385 921101275, Fax: +385 13768303, e-mail:davor.kust@gmail.com Abstract Backgroud/Aim: To assess the clinical significance of nodules in multinodular thyroid if one nodule is diagnosed as papillary carcinoma (PC), we investigated 97 patients with a multinodular thyroid and histopathological diagnosis of PC. Patients and Meth... περισσότερα »
The Management of Cachectic Cancer Patients
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- CHRISTIAN FOCAN, - GHISLAIN HOUBIERS, - LAURA GILLES, - TIPHANY VAN STEELAND, - NADINE GEORGES, - ALEXANDRO MANIGLIA, - JEAN-PIERRE LOBELLE, - VINCENT BARO, - and MARIE-PASCALE GRAAS Dietetic and Psychological Mindfulness Workshops for the Management of Cachectic Cancer Patients. A Randomized StudyAnticancer Res November 2015 35 (11) 6311-6315 1. *Correspondence to:* Christian Focan, MD, Ph.D., CHC; Clinique Saint-Joseph, 75, rue de Hesbaye, B-4000-LIEGE, Belgium. Tel: +32 42248990, Fax: +32 42248991, e-mail: christian.focan@chc.be Abs... περισσότερα »
Melanoma : Long-term Survival with Ipilimumab
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- IVANA KRAJSOVÁ, - PETR ARENBERGER, - RADEK LAKOMÝ, - EUGEN KUBALA, - IVANA BŘEZINOVÁ, - ALEXANDR POPRACH, - MAREK ŠŤASTNÝ, - JAN MUŽÍK, - and BOHUSLAV MELICHAR Long-term Survival with Ipilimumab: Experience from a National Expanded Access Program for Patients with MelanomaAnticancer Res November 2015 35 (11 ) 6303-6310 Abstract Aim: Evaluation of efficacy and safety of ipilimumab in patients with advanced, refractory melanoma enrolled into a national ipilimumab Expanded Access Program. Patients and Methods: Adult patients with advanced/metastatic... περισσότερα »
Prevalence of Vitamin D Deficiency in Patients with Bone Metastases and Multiple Myeloma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- GERRIT STEFFEN MAIER, - KONSTANTIN HORAS, - ANDREAS ALOIS KURTH, - DJORDJE LAZOVIC, - JÖRN BENGT SEEGER, - and UWE MAUS Abstract Background/Aim: *Breast and prostate cancer* are amongst the most prevalent malignancies globally and up to 40% of patients will develop metastatic disease, particularly to the skeleton. Multiple myeloma is the most common cancer to affect bone with up to 90% of patients developing bone lesions. Although several studies demonstrated that endocrine changes such as vitamin D deficiency promote secondary cancer growth in bone, relat... περισσότερα »
Induction Chemotherapy and Sequential Concomitant Chemo-radiation in Locally Advanced Head and Neck Cancers
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- PIERFRANCESCO FRANCO, - ILENIA POTENZA, - MARINA SCHENA, - GIUSEPPE RIVA, - GIANCARLO PECORARI, - PAOLO GARZINO DEMO, - MASSIMO FASOLIS, - FRANCESCO MORETTO, - MASSIMILIANO GARZARO, - JACOPO DI Induction Chemotherapy and Sequential Concomitant Chemo-radiation in Locally Advanced Head and Neck Cancers: How Induction-phase Intensity and Treatment Breaks May Impact on Clinical OutcomesAnticancer Res November 2015 35 (11) 6247-6254 Abstract Aim: The purpose of the study was to assess outcomes of locally advanced head and neck (LAHNC) treated with... περισσότερα »
Metastatic Epidural Spinal Cord Compression (MESCC) from Cancer of Unknown Primary
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- DIRK RADES, - ANTONIO J. CONDE-MORENO, - RAQUEL GARCIA, - THEO VENINGA, - and STEVEN E. SCHILD A Tool to Estimate Survival of Elderly Patients Presenting with Metastatic Epidural Spinal Cord Compression (MESCC) from Cancer of Unknown Primary Abstract Aim: Cancers of unknown primary (CUP) account for about 10% in elderly patients with MESCC. Immediate treatment is indicated. Personalizing treatment for MESCC requires for clear understanding of the patients' survival prognosis. In this case, a tool for estimating survival would be valuable. Patients and Methods:...περισσότερα »
Visualization of the Stomach's Arterial Networks During Esophageal Surgery Using the HyperEye Medical System
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- HIROYUKI KITAGAWA, - TSUTOMU NAMIKAWA, - MASAYA MUNEKAGE, - TOYOKAZU AKIMORI, - MICHIYA KOBAYASHI, - and KAZUHIRO HANAZAKI Abstract Aim: The present study investigated the visualization of the arterial networks in the stomach (ANS) during gastric tube (GT) creation using indocyanine green fluorescence and the HyperEye Medical System (HEMS), and the feasibility of the HEMS-line-marking method (LMM). Patients and Methods: We reviewed 51 consecutive patients who had undergone esophageal surgery with GT reconstruction. Patients for whom the HEMS was deployed ... περισσότερα »
Translocation (1;5) in a Glomus Tumor in the distal extremities of young adults
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- JUN NISHIO, - KAZUKI NABESHIMA, - SHUN MORI, - and MASATOSHI NAITO Abstract Glomus tumor is a rare perivascular neoplasm that usually occurs in the distal extremities of young adults. Recent molecular studies have identified microRNA 143–NOTCH fusions or NOTCH1-3 rearrangements in benign and malignant glomus tumors. Herein, we describe the cytogenetic and molecular cytogenetic findings of a glomus tumor arising in the left wrist of a 45-year-old man. Physical examination showed a 1.3-cm, blue-red, tender nodule. Magnetic resonance imaging demonstrated a subcutan...περισσότερα »
Electrochemotherapy of a Multirecurrent Dermatofibrosarcoma Protuberans of the Orbital Margin
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- ANTONIO BONADIES, - FULVIA ELIA, - FRANCESCO MARIA SOLIVETTI, - ANTONELLO VIDIRI, - LUCA MUSCARDIN, - and STEFANIA BUCHER A Case ReportAbstract Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous sarcoma with high recurrence rate. Radical surgery is the treatment of choice, although in cosmetically-sensitive areas such as the head and neck, this option is often not pursued. Electrochemotherapy (ECT) is a minimal invasive anti-tumor modality which is increasingly being used to treat skin metastases from different malignancies. A 31-year-old wom... περισσότερα »
Tumor Budding, EMT and Cancer Stem Cells in T1-2/N0 Oral Squamous Cell Carcinomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- CECILIE GJØVAAG ATTRAMADAL, - SHEEBA KUMAR, - MORTEN E. BOYSEN, - HARI PRASAD DHAKAL, - JAHN MARTHIN NESLAND, - and MAGNE BRYNE Abstract Background: Early oral carcinomas have a high recurrence rate despite surgery with clear margins. In an attempt to classify the risk of recurrence of oral squamous cell carcinomas, we explored the significance of tumor budding, epithelial–mesenchymal transition (EMT) and certain cancer stem cell markers (CSC). Materials and Methods: Tumor budding (single cells or clusters of ≤5 cells in the tumor front, divided into high...περισσότερα »
Increased Expression of MuRF1 Is Associated with Radiation-induced Laryngeal Muscle Atrophy
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- XIAOCHEN HAN, - LEONARDO PIRES, - J. DALE BROWNE, - CHRISTOPHER A. SULLIVAN, - WEILING ZHAO, - and XIN FENG Abstract Background: Laryngeal muscles play an important role in breathing, sound production and trachea protection against food. Laryngeal dysfunctions during radiotherapy for head and neck cancers are common. In the present study, we aimed to investigate the early effect of radiation on the laryngeal muscles in vivo and possible mechanisms involved in this process. Materials and Methods: Eight-week-old female C57bl/ mice received neck irradiation ...περισσότερα »
Crizotinib Fails to Enhance the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Xenografts
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- ANDREW M. BASCHNAGEL, - SANDRA GALOFORO, - BRYAN J. THIBODEAU, - SAMREEN AHMED, - SONALI NIRMAL, - JAN AKERVALL, - and GEORGE D. WILSON Abstract Aim: Mesenchymal-epithelial transition factor (MET), a receptor tyrosine kinase, is expressed in head and neck squamous cell carcinomas (HNSCC) and is involved in tumor progression and associated with poor prognosis. MET can be inhibited by crizotinib, a potent ATP-competitive kinase inhibitor. We examined the effects of combining crizotinib and radiation in a pre-clinical HNSCC model. Materials and Methods: N... περισσότερα »
Fluorinated β-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- GABRIELLA SPENGLER, - IMRE OCSOVSZKI, - ÁDÁM SZABÓ TÖNKI, - RYOSUKE SAIJO, - GENKI WATANABE, - MASAMI KAWASE, - and JOSEPH MOLNÁR Abstract Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene-transfected L5178Y mouse T-lymphoma cells. Among them, three P-ylides, Ph3P=C(COCF3)COPh, Ph3P=C(COC2F5)COPh and Ph3P=C(COC3F7)... περισσότερα »
Core Needle Biopsy Wash Optimization: Enabling Specimen Integrity for both Cytological and Histological Evaluation
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- WILFRIDO D. MOJICA, - NORA K. FRISCH, - and JOYCE K. PATERSON Core Needle Biopsy Wash Optimization: Enabling Specimen Integrity for both Cytological and Histological EvaluationAbstract Background. The recovery of cells after washing core needle biopsies represents an under-utilized approach to extend the diagnostic capacity of these diminutive specimens. Recovery of these cells can be dedicated for molecular studies so that the biopsy itself can be used apropos for its intended purpose, diagnosis. Non-enzymatic and enzymatic reagents have the potential to increase t... περισσότερα »
Expression of Estrogen Receptors in OSCC in Relation to Histopathological Grade
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- CHRISTIAN DOLL, - RUZA ARSENIC, - HERMANN LAGE, - KORINNA JÖHRENS, - STEFAN HARTWIG, - KATJA NELSON, - and JAN D. RAGUSE Anticancer Res November 2015 35 (11) 5867-5872 Expression of Estrogen Receptors in OSCC in Relation to Histopathological Grade Abstract Background/Aim: Estrogen receptor (ER)-mediated pathways are involved in the pathogenesis of several tumors. Preliminary studies have demonstrated a significant effect of ER agonists and antagonists on oral squamous cell carcinoma (OSCC) cell lines. Recent results suggest that ER subtype-specific exp...περισσότερα »
The Hormetic Dose-response Curve for Anticancer Agents
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- TATSUYA YOSHIMASU, - TAKUYA OHASHI, - SHOJI OURA, - YOZO KOKAWA, - MITSUMASA KAWAGO, - YOSHIMITSU HIRAI, - MIWAKO MIYASAKA, - HARUKA NISHIGUCHI, - SAYOKO KAWASHIMA, - YUMI YATA, - MARIKO HONDA, - TAKAHIRO FUJIMOTO, - and YOSHITAKA OKAMURA A Theoretical Model for the Hormetic Dose-response Curve for Anticancer AgentsAnticancer Res November 2015 35 (11) 5851-5855 Abstract In the present article, we quantitatively evaluated the dose-response relationship of hormetic reactions of anticancer agents in vitro. Serial dilutions of gemcitabi... περισσότερα »
Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Electrochemotherapy – Evidence for Cell-type Selectivity *In Vitro* Abstract Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect and an anti-vascular effect. The aim of the present study was to investigate a possible selective effect of ECT on the survival of fibroblasts, endothelial cells (HUVEC) and two squamous cell carcinoma cell lines (CAL-27 and SCC-4). Materials and Methods: Cells were electroporated using two bleomycin concentrations. The ...περισσότερα »
A field pilot-scale study of biological treatment of heavy oil-produced water by biological filter with airlift aeration and hydrolytic acidification system
Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Heavy oil-produced water (HOPW) is a by-product during heavy oil exploitation and can cause serious environmental pollution if discharged without adequate treatment. Commercial biochemical treatment units are important parts of HOPW treatment processes, but many are not in stable operation because of the toxic and refractory substances, salt, present. Therefore, pilot-scale experiments were conducted to evaluate the performance of hydrolytic acidification-biological filter with airlift aeration (HA-BFAA), a novel HOPW treatment system. Four strains isolated from oily slud...περισσότερα »
Electrochemotherapy – Evidence for Cell-type Selectivity
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- FREDRIK LANDSTRÖM, - MIKAEL IVARSSON, - ANITA KOSKELA VON SYDOW, - ANDERS MAGNUSON, - MATHIAS VON BECKERATH, - and CLAES MÖLLER Electrochemotherapy – Evidence for Cell-type Selectivity *In Vitro*Anticancer Res November 2015 35 (11) 5813-5820 Abstract Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect and an anti-vascular effect. The aim of the present study was to investigate a possible selective effect of ECT on the s...περισσότερα »
Understanding The Anticancer Effect of Metformin and Its Clinical Implications
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- MASSIMILIANO CAZZANIGA and - BERNARDO BONANNI Review: Relationship Between Metabolic Reprogramming and Mitochondrial Activity in Cancer Cells. Understanding The Anticancer Effect of Metformin and Its Clinical ImplicationsAnticancer Res November 2015 35 (11) 5789-5796 Abstract Metabolic reprogramming refers to the ability of cancer cells to alter their metabolism in order to support the increased energy request due to continuous growth, rapid proliferation, and other characteristics typical of neoplastic cells. This adaptation comprises of some important bioenergetic ch... περισσότερα »
Natural Products That Target Cancer Stem Cells
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- JIM MOSELHY, - SOWMYALAKSHMI SRINIVASAN, - MURALI K. ANKEM, - and CHENDIL DAMODARAN Review: Anticancer Res November 2015 35 (11) 5773-5788 Abstract The cancer stem cell model suggests that tumor initiation is governed by a small subset of distinct cells with stem-like character termed cancer stem cells (CSCs). CSCs possess properties of self-renewal and intrinsic survival mechanisms that contribute to resistance of tumors to most chemotherapeutic drugs. The failure to eradicate CSCs during the course of therapy is postulated to be the driving force for tumor recu... περισσότερα »
Therapeutic Potential of Thalidomide and Its Analogues in the Treatment of Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- GAJANAN V. SHERBET Review: Anticancer Res November 2015 35 (11) 5767-5772 - Abstract - Full Text - Full Text (PDF) - Figures Only - Abstract Thalidomide was synthesised and launched several decades ago as a drug against respiratory infections and was administered to pregnant women for relief of morning sickness. The drug was withdrawn when its teratogenic effects came to light. Thalidomide and its analogues suppressed cell proliferation and angiogenesis and controlled invasion and metastasis of tumours in pre-clinical studies. With the... περισσότερα »
Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- MICHAEL KOCH, - ANNE J. FREUNDL, - ABBAS AGAIMY, - FRANKLIN KIESEWETTER, - JULIAN KÜNZEL, - IWONA CICHA, - and CHRISTOPH ALEXIOU Review: Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of TherapyAnticancer Res November 2015 35 (11) 5717-5735 - Abstract - Full Text - Full Text (PDF) - Figures Only - FREE - - Abstract Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis. Thus far, there are no guidelin... περισσότερα »
Cancer Genomics Proteomics
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
November-December 2015 12 (6) 403-420 - Full Text (PDF) OPEN ACCESS ARTICLE
Cytotoxic Activities of Eosinophil Cationic Protein and Eosinophil-derived Neurotoxin
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
: *In Silico* Analysis Abstract Background: Eosinophil cationic protein (ECP) and eosinophil derived-neurotoxin (EDN) are homologous ribonuclease (RNAse) A family proteins. The objective of the present study was to in silico characterize ECP and EDN with respect to their cytotoxic activities. Materials and Methods: Structural, physicochemical, and conserved domain characterizations were carried-out using open-source software, such as InterProScan, NetOGlyc, NetPhos and Discovery Studio 3.1. Results: The proteins did not have atypical conserved domains. EDN had a greater number of gl...περισσότερα »
Use of ICT Tools to Trace Biosample Life-cycle
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Ensuring Sample Quality for Biomarker Discovery Studies – Use of ICT Tools to Trace Biosample Life-cycle Abstract The growing demand of personalized medicine marked the transition from an empirical medicine to a molecular one, aimed at predicting safer and more effective medical treatment for every patient, while minimizing adverse effects. This passage has emphasized the importance of biomarker discovery studies, and has led sample availability to assume a crucial role in biomedical research. Accordingly, a great interest in Biological Bank science has grown concomitantly. In bioban...περισσότερα »
A Novel Approach to Evaluating Cancer Driver Gene Mutation Densities: Cytoskeleton-related Gene Candidates
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
A Novel Approach to Evaluating Cancer Driver Gene Mutation Densities: Cytoskeleton-related Gene Candidates Abstract Background: Oncoprotein genes are over-represented in statically defined, low mutation-frequency fractions of cancer genome atlas (TCGA) datasets, consistent with a higher driver mutation density. Materials and Methods: We developed a “continuously variable fraction” (CVF) approach to defining high and low mutation-frequency groups. Results and Conclusion: Using the CVF approach, an oncoprotein set was shown to be associated with a TCGA, low mutation-frequency group in...περισσότερα »
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
- XIANYIN LAI and - SHAOXIONG CHEN Cancer Genomics Proteomics November-December 2015 12 (6) 271 Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma Abstract Follicular adenoma is a type of benign and encapsulated nodule in the thyroid gland, but some adenomas have the potential to progress to follicular carcinoma. Therefore, it is important to monitor the state and progress of follicular adenoma in the clinic and discover drug development targets for the treatment of follicular adenoma to prevent its wors... περισσότερα »
The flavonoid quercetin exerts significant anti-inflammatory activity against chronic infections, including periodontal disease
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
In Vivo. 2015 11-12;29(6):701-710. Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters. Murakami Y1, Kawata A2, Ito S3, Katayama T2, Fujisawa S2. Author information - 1Department of Diagnostic and Therapeutic Sciences, Division of Oral Diagnosis and General Dentistry, Meikai University School of Dentistry, Sakado City, Saitama, Japan ymura@dent.meikai.ac.jp. - 2Depa... περισσότερα »
Radiation Therapy for Metastatic Spinal Cord Compression
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
In Vivo. 2015 11-12;29(6):749-752. [image: Icon for HighWire] Radiation Therapy for Metastatic Spinal Cord Compression in Patients with Hepatocellular Carcinoma. Rades D1, Dahlke M2, Janssen S3, Gebauer N4, Bartscht T4. Author information 1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Rades.Dirk@gmx.net. 2Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany. 4Department of Hematology and Oncology... περισσότερα »
Effects of Targeted Proton Radiation on Spinal Cord
Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 ώρες
in a Porcine Model: A Pilot Study 1. XIAO WEN MAO1, 2. MICHAEL J. PECAUT1, 3. JEFFREY D. CAO2 and 4. DAILA S. GRIDLEY1⇑ -Author Affiliations 1. 1Department of Basic Sciences, Division of Radiation Research, Loma Linda University School of Medicine, Loma Linda, CA, U.S.A. 2. 2Department of Human Anatomy & Pathology, Loma Linda University School of Medicine and Medical Center, Loma Linda, CA, U.S.A. 1. *Correspondence to:* Daila S. Gridley, Ph.D., Department of Basic Sciences, Division of Radiation Research, Chan Shun Pavilion, 11175 Campus Street,... περισσότερα »
BacterioFiles 237 - Proving Protist Predation Parentage
Alexandros G. SfakianakisστοΛοίμωξηΠριν από 2 ώρες
This episode: *Vampirovibrio chlorellavorus*, a predatory bacterium that feeds on *Chlorella* algae, is currently lost from science, but its genome has been sequenced and interpreted anyway, to reveal a surprising family history! (9.4 MB, 10.25 minutes) from Infection via ola Kala on Inoreader http://ift.tt/1kEM1y0 via IFTTT
OtoRhinoLaryngology New Articles,November 8th,2015
Αλέξανδρος ΣφακιανάκηςστοOtolaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Cupid and Psyche *Alexandros G. SfakianakisστοHead and NeckΠριν από 9 ώρες* * Alexandros Sfakianakis Anapafseos 5 . Agios Nikolaos Crete.Greece.72100 2841026182,6932607174* Microbiology *Alexandros G. SfakianakisστοΛοίμωξηΠριν από 9 ώρες* * Transcriptional analysis of exopolysaccharides biosynthesis gene clusters in Lactobacillus plantarum Abstract Exopolysaccharides (EPS) from lactic acid bacteria contribute to specific rheology and texture of fermented milk products and find applications also in non-dairy foods and in therapeutics. Recently, four clusters of genes ( *cps*) associate... περισσότερα »
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