Perceived social support and health-related quality of life in AYA cancer survivors and controls
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Perceived social support and health-related quality of life in AYA cancer survivors and controls: Abstract Background This study compared education levels, health-related quality of life (HRQoL) and perceived social support of adolescent and young adult (AYA) cancer survivors with those of a control group of peers with no history of serious illness. The links between socio-demographic and medical factors and AYA cancer survivor outcomes were investigated. Methods The participants included AYA cancer survivors (*n* = 205) recruited during follow-up visits, and AYA peers (*n* = 205) r...περισσότερα »
Economic evaluations of psychosocial interventions in cancer: a systematic review
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Economic evaluations of psychosocial interventions in cancer: a systematic review: Abstract Objective Although the effectiveness of many psychosocial interventions for people with cancer has been established, one barrier to implementation in routine clinical care is a lack of data on cost-effectiveness. We conducted a systematic review to assess the cost-effectiveness of psychosocial interventions for improving psychological adjustment among people with cancer. Methods A systematic review of the literature, study appraisal and narrative synthesis. Results Eight studies involving 16...περισσότερα »
The financial impact of head and neck cancer caregiving: a qualitative study
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
The financial impact of head and neck cancer caregiving: a qualitative study: Abstract Background There is a lack of research on the financial impacts that head and neck cancer has on caregivers. Objective To explore the overall financial impact of head and neck cancer on caregivers; to describe the factors that mitigate this impact. Methods Interviews with 31 caregivers (mean time caring: 5.7 years). Results Head and neck cancer had a considerable financial impact on caregivers. It resulted in out of pocket costs and caregivers and/or their relative/friend with cancer often became u... περισσότερα »
Selection and expansion of natural killer cells for NK cell-based immunotherapy
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Selection and expansion of natural killer cells for NK cell-based immunotherapy: AbstractNatural killer (NK) cells have been used in several clinical trials as adaptive immunotherapy. The low numbers of these cells in peripheral blood mononuclear cells (PBMC) have resulted in various approaches to preferentially expand primary NK cells from PBMC. While some clinical trials have used the addition of interleukin 2 (IL-2) to co-stimulate the expansion of purified NK cells from allogeneic donors, recent studies have shown promising results in achieving in vitro expansion of NK cells to... περισσότερα »
ASP9853, an inhibitor of inducible nitric oxide synthase dimerization, in combination with docetaxel: preclinical investigation and a Phase I study in advanced solid tumors
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
ASP9853, an inhibitor of inducible nitric oxide synthase dimerization, in combination with docetaxel: preclinical investigation and a Phase I study in advanced solid tumors: Abstract PurposeASP9853 is an inhibitor of inducible nitric oxide (NO) synthase (iNOS) dimerization, which results in decreased NO production. Here, we report preclinical pharmacology of ASP9853 and the impact of ASP9853 in combination with a taxane on tumor volume in vivo. In addition, a Phase I open-label study of ASP9853 plus docetaxel was conducted to assess this combination in patients with advanced solid...περισσότερα »
IL-6 and MCP-1 genetic polymorphisms are predictive of decreased platelet counts caused by chemoradiotherapy in esophageal cancer
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
IL-6 and MCP-1 genetic polymorphisms are predictive of decreased platelet counts caused by chemoradiotherapy in esophageal cancer: Abstract BackgroundA reliable marker of the sensitivity of esophageal cancer to chemoradiotherapy (CRT) as well as a personal biomarker predictive of adverse events during treatment has long been sought. The purpose of the present study was to test whether there is an association between interleukin-6 (IL-6) and/or monocyte chemoattractant protein-1 (MCP-1) polymorphisms and CRT-induced bone-marrow suppression––i.e., reductions in white blood cell and/...περισσότερα »
Role of Increased n-acetylaspartate Levels in Cancer
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Role of Increased n-acetylaspartate Levels in Cancer: Background: The clinical and biological effects of metabolic alterations in cancer are not fully understood. Methods: In high-grade serous ovarian cancer (HGSOC) samples (n = 101), over 170 metabolites were profiled and compared with normal ovarian tissues (n = 15). To determine NAT8L gene expression across different cancer types, we analyzed the RNA expression of cancer types using RNASeqV2 data available from the open access The Cancer Genome Atlas (TCGA) website ( http://www.cbioportal.org/public-portal/). Using NAT8L siRNA, m...περισσότερα »
Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy: Abstract To explore the influence of pretreatment lymphopenia on the toxicity and efficacy of first-line chemotherapy in patients with metastatic esophagus squamous cell carcinoma (ESCC). In total, 215 patients were included in this retrospective study. Correlations between pretreatment lymphopenia (lymphocyte count <1 × 109/L) and the occurrence of toxicity and the efficacy of first-line palliative chemot... περισσότερα »
Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study: Abstract BackgroundThe Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully explored. The purpose of this study was to determine the clinical significance of NLR in patients with OSCC. MethodsOSCC patients who underwent surgery following 5-fluorouracil (5-FU)-based ch... περισσότερα »
American College of Radiology (ACR) Radiation Oncology Practice Accreditation
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
: A pattern of change via Practical Radiation Oncology Publication date: Available online 26 January 2016 *Source:*Practical Radiation Oncology Author(s): Shannon E. Fogh, Christopher H. Pope, Seth A. Rosenthal, Patrick D. Conway, Peter R. Hulick, Jennifer L. Johnson, Tariq A. Mian, Indra J. Das, Ann Lazar, Nikhil G. Thaker, Brian T. Monzon PurposeThe ACR Radiation Oncology Practice Accreditation (ROPA) program has accredited over 600 sites since 2006 including practices within academic, hospital based, and freestanding settings. The purpose of this report is to evaluate and compare pa...περισσότερα »
Accuracy of beam localization for brain tumor treatment by CyberKnife
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Log-file analysis of via Practical Radiation Oncology Publication date: Available online 26 January 2016 *Source:*Practical Radiation Oncology Author(s): Hiroyuki Okamoto, Minoru Hamada, Emi Sakamoto, Akihisa Wakita, Satoshi Nakamura, Toru Kato, Yoshihisa Abe, Kana Takahashi, Hiroshi Igaki, Jun Itami The CyberKnife system generates log-files including actual treatment parameters for each procedure. In this study, log-files were analyzed to evaluate the mechanical uncertainty in beam localization over the long term (approximately one year), as well as patterns of patient movements duri... περισσότερα »
Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment.
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Spontaneous regression of tumour and the role of microbial infection - possibilities for cancer treatment.: This review deals with the role of microorganisms in spontaneous regression of a tumour. Spontaneous cancer regression is a phenomenon that has been described for many centuries. One of the most well known methods of inducing spontaneous regression of cancer is the application of Coley's toxin (heat-killed Streptococcus pyogenes and Serratia marcescens), which has been used for the successful treatment of sarcomas, carcinomas, lymphomas, myelomas and melanomas. In clinical pra...περισσότερα »
Denosumab in a dialysis patient with bone metastases
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Use of denosumab in a dialysis patient with bone metastases from breast cancer and hepatorenal polycystic disease: a case report.: Cancer patients with severe renal dysfunction represent a challenge for the physician. This is the first case report on the use of denosumab in a dialysis patient with bone metastases. We present the clinical case of a 45-year-old woman who had hepatorenal polycystic disease, diagnosed during childhood, and stage IV chronic kidney failure at the time of breast cancer diagnosis. Three years after surgery plus adjuvant hormonal therapy she suffered a furthe... περισσότερα »
An adaptive immune response driven by mature, antigen-experienced T and B cells within the microenvironment of oral squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
An adaptive immune response driven by mature, antigen-experienced T and B cells within the microenvironment of oral squamous cell carcinoma: Abstract Lymphocyte infiltrates have been observed in the microenvironment of oral cancer; however, little is known about whether the immune response of the lymphocyte infiltrate affects tumor biology. For a deeper understanding of the role of the infiltrating-lymphocytes in oral squamous cell carcinoma (OSCC), we characterized the lymphocyte infiltrate repertoires and defined their features. Immunohistochemistry revealed considerable T and B c...περισσότερα »
The proportion cured of patients diagnosed with stage III-IV cutaneous malignant melanoma
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
The proportion cured of patients diagnosed with stage III-IV cutaneous malignant melanoma in Sweden 1990-2007: A population-based study: Abstract The survival in cutaneous malignant melanoma (CMM) is highly dependent on the stage of the disease. Stage III-IV CMM patients are at high risk of relapse with a heterogeneous outcome, but not all experience excess mortality due to their disease. This group is referred to as the cure proportion representing the proportion of patients who experience the same mortality rate as the general population. The aim of this study was to estimate the... περισσότερα »
The cultural constructs of cancer-related fatigue
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
The cultural constructs of cancer-related fatigue among American Indian cancer survivors: Abstract PurposeCancer-related fatigue (CRF) is a common symptom experienced by cancer survivors. Persistent fatigue can last years after cancer treatment. CRF’s origin is unknown, and there are no validated treatments. Cultural constructs (definitions, meaning, and explanations) may vary the presentation and treatment choices related to fatigue. Identifying and categorizing CRF terms and experiences among racial, ethnic, and non-English speaking groups may provide a fuller understanding of C...περισσότερα »
sequential cisplatin-topotecan/carboplatin-paclitaxel versus carboplatin-paclitaxel
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Randomized study of sequential cisplatin-topotecan/carboplatin-paclitaxel versus carboplatin-paclitaxel: effects on quality of life: Abstract BackgroundA recent phase III trial compared the efficacy of cisplatin-topotecan (a topoisomerase I inhibitor) followed by carboplatin-paclitaxel (Arm 1) versus paclitaxel-carboplatin (Arm 2) in women with newly diagnosed stage IIB or greater ovarian cancer. There was a significantly lower response rate in the experimental arm compared to standard treatment, and less likelihood of normalized CA125 within the first 3 months. At 43 months follo... περισσότερα »
Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia: Abstract PurposeMuscle atrophy is the prominent clinical feature of cancer-induced cachexia. Zhimu and Huangbai herb pair (ZBHP) has been used since ancient China times and have been phytochemically investigated for constituents that might cause anti-cancer, diabetes, and their complication. In this study, the effects and mechanisms of ZBHP on reversal of muscle atrophy were explored. MethodsC57BL/6 mice implanted with colon-26 adenocarcinoma were chos... περισσότερα »
Pegfilgrastim administration after 24 or 72 or 96 h to allow dose-dense anthracycline- and taxane-based chemotherapy
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Pegfilgrastim administration after 24 or 72 or 96 h to allow dose-dense anthracycline- and taxane-based chemotherapy in breast cancer patients: a single-center experience within the GIM2 randomized phase III trial: Abstract PurposeTo evaluate the safest timing of pegfilgrastim administration in dose-dense anthracycline- and taxane-based chemotherapy, three different cohorts of patients enrolled in the *Gruppo Italiano Mammella* (GIM) 2 study and treated at the coordinating center received pegfilgrastim 24 h (cohort A) or 72 h (cohort B) or 96 h (cohort C) after chemotherapy. Me... περισσότερα »
Evaluation of a weekly speech pathology/dietetic service model for providing supportive care intervention to head and neck cancer patients and their carers during (chemo)radiotherapy
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Evaluation of a weekly speech pathology/dietetic service model for providing supportive care intervention to head and neck cancer patients and their carers during (chemo)radiotherapy: Abstract PurposeDysphagia is a common and debilitating side effect for head and neck cancer (HNC) patients undergoing radiotherapy (RT) with or without chemotherapy ([C]RT) and is associated with nutritional and emotional comorbidities. Emotional sequelae and distress are also known to affect carers of HNC patients. A weekly, joint speech pathology/dietetic (SP/DN) service-delivery model has been emp... περισσότερα »
Zoledronic acid for treatment of osteopenia and osteoporosis
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Zoledronic acid for treatment of osteopenia and osteoporosis in women with primary breast cancer undergoing adjuvant aromatase inhibitor therapy: a 5-year follow-up: Abstract PurposeThis study was designed to explore whether zoledronic acid could prevent expected loss of bone mineral density (BMD) in postmenopausal women with pre-existing osteopenia or osteoporosis who were initiating adjuvant letrozole therapy for primary breast cancer. MethodsBetween June 2006 and July 2007, 60 postmenopausal women with estrogen and/or progesterone receptor-positive breast cancer and a BMD T...περισσότερα »
anthracycline-based chemotherapy : 1 day versus 3 days of dexamethasone combined with palonosetron and aprepitant to prevent nausea and vomiting
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Phase II randomized, controlled trial of 1 day versus 3 days of dexamethasone combined with palonosetron and aprepitant to prevent nausea and vomiting in Japanese breast cancer patients receiving anthracycline-based chemotherapy: Abstract PurposeDexamethasone, plus a 5-HT3 receptor antagonist and an NK-1 receptor antagonist are recommended for controlling the chemotherapy-induced nausea and vomiting (CINV) of highly emetogenic chemotherapy. Several days of dexamethasone are effective for CINV; however, dexamethasone also has side effects. The purpose of this trial was to investiga... περισσότερα »
Venous access: the patient experience
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Venous access: the patient experience: Abstract IntroductionThe evolution of venous access via peripheral cannulation, particularly in relation to the risks and the benefits of this procedure, is reported widely in the literature. However, there is limited research specific to the patient experience of undergoing venous access. AimThe intent of this qualitative study was to understand patients’ experience of venous access, with the aim of bringing forth their voices about the experiences of repeated venous access/cannulation attempts. MethodologyThis qualitative study used a... περισσότερα »
Phase II evaluation of S-adenosyl-L-methionine (SAMe) for the treatment of hot flashes
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Phase II evaluation of S-adenosyl-L-methionine (SAMe) for the treatment of hot flashes: Abstract PurposeHot flashes are a significant source of symptom burden that negatively impacts quality of life (QOL). For women who have contraindications to, or are unwilling to consider, estrogens or antidepressants for bothersome hot flashes, there are limited effective pharmacologic or complementary and alternative medicines. MethodsThis single-arm phase II trial studied the efficacy of S-adenosyl-L-methionine (SAMe) for the treatment of hot flashes. Eligible women were required to have... περισσότερα »
Sixty-minute infusion rituximab protocol allows for safe and efficient workflow
Alexandros G. SfakianakisστοHead,Neck and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
Sixty-minute infusion rituximab protocol allows for safe and efficient workflow: Abstract PurposeRituximab is a chimeric monoclonal antibody approved to treat B cell non-Hodgkin’s lymphoma (NHL). Infusion reactions among NHL patients are common during the first exposure but decrease with subsequent infusions. We sought to assess the safety and feasibility of a rituximab rapid infusion protocol in the outpatient treatment area of a comprehensive cancer center. Patients and methodsPatients with indolent and intermediate B cell NHL were invited to enroll in this prospective, singl... περισσότερα »
Bericht zum 9. ASA TCM-Kongress in Solothurn: Thema «Wandlungsphase Feuer»
Schweiz Z Ganzheitsmed 2016;28:23-25 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PmNYeN via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nsna1E via IFTTT
Early HIV treatment to forestall drug resistance
Publication date: Available online 29 January 2016 Source:The Lancet Infectious Diseases Author(s): Mark A Wainberg from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nslZzm via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PmPoWs via IFTTT
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study
Publication date: Available online 29 January 2016 Source:The Lancet Infectious Diseases Author(s): The TenoRes Study Group BackgroundAntiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat and prevent HIV, although few data exist for frequency and risk… Continue reading Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre ... περισσότερα »
New molecular profiling for glioma
Novel, more accurate classification for brain tumors may open new therapeutic targets and help physicians to choose treatment. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PJpQ80 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nsn5ez via IFTTT
Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases
Background: Management options for pancreatic neuroendocrine tumors (pNETs) metastatic to the liver include surgical, ablative, cytotoxic, and radioisotope approaches. One potential local treatment option includes selective internal radiotherapy utilizing yttrium-90 (90Y) microspheres. 90Y has also been used in the treatment of hepatocellular carcinoma and tumors metastatic to the liver. It appears to be well tolerated;… Continue reading Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases
Scientists decode brain signals nearly at speed of perception
Using electrodes implanted in the temporal lobes of awake patients, scientists have decoded brain signals at nearly the speed of perception. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PJpPB3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PmPnSl via IFTTT
Unusual large functional adrenocortical carcinoma in a young woman
Description A 27-year-old woman presented with an abdominal lump and features of Cushing syndrome with virilisation, namely, weight gain, acne, hyperpigmentation, hirsutism, central obesity, rounded face, stretch marks, osteoporosis, dyslipidaemia, hypertension and amenorrhoea (figure 1). Serum testosterone and cortisol levels were elevated. Oestradiol and 24 h urinary metanephrine were within normal range. contrast-enhanced CT of… Continue reading Unusual large functional adrenocortical carcinoma in a young woman
BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula
The Use of BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula post extirpation of buccal squamous cell carcinoma with immediate reconstruction utilizing microvascular free flap. A Report of Three Cases via Oral and Maxillofacial Surgery Publication date: Available online 29 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): James Melville, Daniel Stackowicz,… Continue reading BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula
Traumatic dysgeusia, a complication of facial trauma
: A case report. via Oral and Maxillofacial Surgery Publication date: Available online 28 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): João Paulo Bonardi, Fernanda Herrera da Costa, Glaykon Alex Vitti Stabile, Cecilia Luiz Pereira- Stabile The chemical senses of taste and smell are important to human life, as they play an important… Continue reading Traumatic dysgeusia, a complication of facial trauma
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension: Abstract Chondrosarcoma of the faciomaxillary area constitute only 4 % of non-epithelial tumours of the nasal cavity, paranasal sinuses and nasopharynx, making it one of the rare malignancy (Indian J Otolaryngol Head Neck Surg 60(3):284–286, [1]), with its myxoid variety still rarest. It is a slow-growing tumour,… Continue reading Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension
Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπτα
Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma: AbstractWith increasing numbers of patients with unresectable locoregionally advanced (LA) head and neck squamous cell carcinoma (HNSCC) receiving cetuximab/radiotherapy (RT), several guidelines on the early detection and management of skin-related toxicities have been developed. Considering the existing management guidelines for these treatment-induced conditions, clinical applicability...περισσότερα »
Perioperative stroke in general surgery
Clinical diagnostic tools for screening of perioperative stroke in general surgery: a systematic review: Perioperative stroke is a devastating complication that carries high mortality and functional disability. Unfortunately, residual anaesthesia and analgesia may obscure important warning signs and may lead to a delay in the assessment and treatment of major stroke after surgery. The purpose of this review is to examine the utility of existing stroke scales, for the recognition of perioperative stroke in the general surgical population. A total of 21 stroke scales have been descri... περισσότερα »
Cricoid pressure impedes tracheal intubation with the Pentax-AWS Airwayscope(R): a prospective randomized trial
Cricoid pressure impedes tracheal intubation with the Pentax-AWS Airwayscope(R): a prospective randomized trial: Background It is unclear how cricoid pressure affects tracheal intubation with the Pentax-AWS Airwayscope® (AWS). We conducted a prospective randomized clinical trial in anaesthetized patients. Methods Sixty patients were allocated to either the cricoid pressure (CP) group (*n*=30) or the sham group (*n*=30). We compared the two groups with regard to intubation time, number of attempts required for insertion of the Intlock blade (disposable blade of the AWS) and tracheal...περισσότερα »
Videolaryngoscopes: do they have role during rapid-sequence induction of anaesthesia?
Videolaryngoscopes: do they have role during rapid-sequence induction of anaesthesia? 1. T. Asai -Author Affiliations 1. Department of Anesthesiology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya City, Saitama 343-8555, Japan 1. E-mail: asaita@dokkyomed.ac.jp Rapid-sequence induction of anaesthesia is indicated in patients who are at increased risk of pulmonary aspiration. Generally, difficult or failed tracheal intubation in itself does not endanger the patient's life, but in patients at risk of pulmonary aspiration, difficult ... περισσότερα »
Simulation as a set-up for technical proficiency: can a virtual warm-up improve live fibre-optic intubation?
Simulation as a set-up for technical proficiency: can a virtual warm-up improve live fibre-optic intubation?: Background Fibre-optic intubation (FOI) is an advanced technical skill, which anaesthesia residents must frequently perform under pressure. In surgical subspecialties, a virtual ‘warm-up’ has been used to prime a practitioner's skill set immediately before performance of challenging procedures. This study examined whether a virtual warm-up improved the performance of elective live patient FOI by anaesthesia residents. Methods Clinical anaesthesia yr 1 and 2 (CA1 and CA2) re... περισσότερα »
Evaluation of Sexual Dysfunction in men with Spinal Cord Injury using the Male Sexual Quotient
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Publication date: Available online 29 January 2016 Source:Archives of Physical Medicine and Rehabilitation Author(s): Eduardo de Paula Miranda, Cristiano Mendes Gomes, José de Bessa, Carmita Helena Najjar Abdo, Carlos Henrique Suzuki Bellucci, Jose Everton de Castro Filho, Fabrício Leite de Carvalho, Daniel Rubio de Souza, Linamara Rizzo Battistella, Márcia Scazufca, Homero Bruschini, Tarcisio E.P. Barros […]
Perceived social support and health-related quality of life in AYA cancer survivors and controls
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Perceived social support and health-related quality of life in AYA cancer survivors and controls: Abstract Background This study compared education levels, health-related quality of life (HRQoL) and perceived social support of adolescent and young adult (AYA) cancer survivors with those of a control group of peers with no history of serious illness. The links between […]
Economic evaluations of psychosocial interventions in cancer: a systematic review
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Economic evaluations of psychosocial interventions in cancer: a systematic review: Abstract Objective Although the effectiveness of many psychosocial interventions for people with cancer has been established, one barrier to implementation in routine clinical care is a lack of data on cost-effectiveness. We conducted a systematic review to assess the cost-effectiveness of psychosocial interventions for improving […]
“Reps” Aren’t Enough: Augmenting Functional Electrical Stimulation With Behavioral Supports Significantly Reduces Impairment in Moderately Impaired Stroke
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Archives of Physical Medicine and Rehabilitation Author(s): Stephen J. Page, Peter G. Levine, Brittani Basobas ObjectiveTo determine the impact of repetitive task-specific practice (RTP) integrating electrical stimulation and behavioral supports on upper extremity (UE) impairment, gross manual dexterity, and paretic UE amount and quality of use in chronic […]
Toward the International Classification of Functioning, Disability and Health (ICF) Rehabilitation Set: A minimal generic set of domains for rehabilitation as a health strategy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Archives of Physical Medicine and Rehabilitation Author(s): Birgit Prodinger, Alarcos Cieza, Cornelia Oberhauser, Jerome Bickenbach, Tevfik Bedirhan Üstün, Somnath Chatterji, Gerold Stucki ObjectiveTo develop a comprehensive set of categories from the International Classification of Functioning, Disability and Health (ICF) as a minimal standard for reporting and assessing functioning […]
Anomalous left main coronary artery detected by CT angiography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 6 δευτερόλεπτα
Abstract The growing improvements of computed tomography have made this technique more and more available for cardiac evaluation. Coronary artery anomalies (CAAs) are often incidental findings in subjects with suspected coronary artery disease (CAD) undergoing coronary angiography or computed tomography coronary angiography (CTCA). In some cases, CAAs can be clinically relevant so their identification could […]
Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction
Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction via Clinical Immunology Publication date: Available online 28 January 2016 *Source:*Clinical Immunology Author(s): Arjun Sharma, Jeremy Kiripolsky, Ekaterina Klimatcheva, Alan Howell, Farzad Fereidouni, Richard Levenson, Thomas L. Rothstein, Jill M. Kramer Sjögren's syndrome (SS) is a debilitating autoimmune disease. Patients with SS may develop xerostomia. This process is progressive, and there are no therapeutics that target disease e... περισσότερα »
Prime and boost aerosol exposure via fog machine or shisha smoke followed by cinnamon hypersensitivity and anaphylaxis to spiced food
Prime and boost aerosol exposure via fog machine or shisha smoke followed by cinnamon hypersensitivity and anaphylaxis to spiced food: Background: Cinnamon aldehyde (alias cinnamaldehyde) is widely used in food, textile or cosmetic industry. It is mostly associated with contact allergy, but immediate type allergies have been reported. The present study was triggered by a case of anaphylactic events to cinnamon in food and upon skin prick test. We investigated a possible correlation of exposure to a disco fog machine and/or shisha consumption with immediate type hypersensitivity to ci...περισσότερα »
The financial impact of head and neck cancer caregiving: a qualitative study
The financial impact of head and neck cancer caregiving: a qualitative study: Abstract Background There is a lack of research on the financial impacts that head and neck cancer has on caregivers. Objective To explore the overall financial impact of head and neck cancer on caregivers; to describe the factors that mitigate this impact. Methods… Continue reading The financial impact of head and neck cancer caregiving: a qualitative study
Therapy: Targeting replication fork stalling
Nature Reviews Cancer 16, 70 (2016). doi:10.1038/nrc.2016.10 Author: Gemma K. Alderton G-quadruplexes (G4) are naturally occurring DNA structures that stall replication forks. Homologous recombination (HR)stabilizes and restarts stalled replication forks and also repairs double-strand breaks (DSBs) that can form at these sites. Zimmer et al. show that the G4-stabilizing compound pyridostatin (PDS) induced DSB accumulation… Continue reading Therapy: Targeting replication fork stalling
The kinome ‘at large’ in cancer
Nature Reviews Cancer 16, 83 (2016). doi:10.1038/nrc.2015.18 Authors: Emmy D. G. Fleuren, Luxi Zhang, Jianmin Wu & Roger J. Daly Over the past decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome ‘at… Continue reading The kinome ‘at large’ in cancer
Management of Hyperleukocytosis
Opinion statement Hyperleukocytosis has a high morbidity index. The involvement of the respiratory or central nervous system and the metabolic derangements accompanying tumor lysis are responsible for early mortality. Standard care for acute hyperleukocytosis must include cytoreduction, proper supportive care, and prevention of tumor lysis. Hydration, alkalization, allopurinol, or urate oxidase should be started immediately.… Continue reading Management of Hyperleukocytosis
Pancreatic cancer: Spotlight on B cells
Nature Reviews Cancer 16, 67 (2016). doi:10.1038/nrc.2016.7 Author: Sarah Seton-Rogers Three papers published in Cancer Discovery show that B cells have diverse contributions to pancreatic tumorigenesis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1m0BgGz via IFTTT
Acquired resistance to immunotherapy and future challenges
Nature Reviews Cancer 16, 121 (2016). doi:10.1038/nrc.2016.2 Authors: Nicholas P. Restifo, Mark J. Smyth & Alexandra Snyder Advances in immunotherapy have resulted in remarkable clinical responses in some patients. However, one of the biggest challenges in cancer therapeutics is the development of resistant disease and disease progression on or after therapy. Given that many patients… Continue reading Acquired resistance to immunotherapy and future challenges
The Role of Surgery in Metastatic Gastrointestinal Stromal Tumors
Opinion statement Gastrointestinal stromal tumors (GISTs) are the most common sarcomas and mesenchymal neoplasms of the gastrointestinal tract. Macroscopically complete (R0/R1) resection is the standard treatment for localized resectable GIST with adjuvant imatinib therapy recommended for patients with intermediate or high-risk disease. In patients with advanced unresectable or metastatic GIST, imatinib has significantly improved outcomes.… Continue reading The Role of Surgery in Metastatic Gastrointestinal Stromal Tumors
Traumatic dysgeusia, an unusual complication of facial trauma: A case report.
Publication date: Available online 28 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): João Paulo Bonardi, Fernanda Herrera da Costa, Glaykon Alex Vitti Stabile, Cecilia Luiz Pereira- Stabile The chemical senses of taste and smell are important to human life, as they play an important role in detecting potential environmental hazards. Humans are able… Continue reading Traumatic dysgeusia, an unusual complication of facial trauma: A case report.
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
Nature Reviews Cancer 16, 99 (2016). doi:10.1038/nrc.2015.17 Authors: Alex R. D. Delbridge, Stephanie Grabow, Andreas Strasser & David L. Vaux The ‘hallmarks of cancer’ are generally accepted as a set of genetic and epigenetic alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows that therapies designed to counter… Continue reading Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
The Use of BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula post extirpation of buccal squamous cell carcinoma with immediate reconstruction utilizing microvascular free flap. A Report of Three Cases
Publication date: Available online 29 January 2016 Source:Journal of Oral and Maxillofacial Surgery Author(s): James Melville, Daniel Stackowicz, Jonathon S. Jundt, Jonathan W. Shum Buccal squamous cell carcinoma is an aggressive form of oral carcinoma with a high recurrence rate.1 Injury to the parotid duct is often unavoidable when surgically treating buccal squamous cell carcinoma… Continue reading The Use of BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula post extirpation of buccal squamous cell carcinoma with immediate reconstruction utilizing mic... περισσότερα »
Low Level of Cryoglobulin (< 0.05g/L) : Non-HCV cryoglobulin level≤0.05g/L may be responsible with severe renal and neurological complications, leading to high morbidity and mortality
Long Term Outcome of Patients With via Autoimmunity Reviews Publication date: Available online 28 January 2016 *Source:*Autoimmunity Reviews Author(s): V. Eble, B. Legallicier, P. Joly, O. Vittecoq, F. Caron, F. Tamion, P. Ducrotte, H. Levesque, J.-F. Menard, F. Jouen, D. Guerrot, I. Marie ObjectivesTo date, no studies have yet assessed the characteristics of non-HCV patients with low level of cryoglobulin (≤ 0.05g/L). The aims of the current study were thus to: 1) determine the prevalence of cryoglobulin ≤0.05g/L in patients with non-HCV cryoglobulin; and 2) compare clinical feature...περισσότερα »
Periarticular Cysts Of The Temporomandibular Joint
Are More Frequently Synovial Than Ganglion via Oral and Maxillofacial Surgery Publication date: Available online 28 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): J. Partridge, N. Cipriani, W.C. Faquin, S.K. Chuang, D.A. Keith, E. Lahey PurposeDifferentiating between ganglion and synovial cysts by standard histology is difficult, leading to inaccurate statements on frequency for each of these periarticular lesions. The purpose of this study is to use immunohistochemical (IHC) analysis to 1) calculate the accuracy of the histological diagnoses, 2) determine ...περισσότερα »
BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula
The Use of BOTOX®(onabotulinumtoxin A) for the treatment of parotid sialocele and fistula post extirpation of buccal squamous cell carcinoma with immediate reconstruction utilizing microvascular free flap. A Report of Three Cases via Oral and Maxillofacial Surgery Publication date: Available online 29 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): James Melville, Daniel Stackowicz, Jonathon S. Jundt, Jonathan W. Shum Buccal squamous cell carcinoma is an aggressive form of oral carcinoma with a high recurrence rate.1Injury to the parotid duct is often unavoid...περισσότερα »
Traumatic dysgeusia, a complication of facial trauma
: A case report. via Oral and Maxillofacial Surgery Publication date: Available online 28 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): João Paulo Bonardi, Fernanda Herrera da Costa, Glaykon Alex Vitti Stabile, Cecilia Luiz Pereira- Stabile The chemical senses of taste and smell are important to human life, as they play an important role in detecting potential environmental hazards. Humans are able to identify countless different flavors by means of the simultaneous perception of taste and smell. Reports of sensory loss after craniocerebral trauma began to ... περισσότερα »
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension
Myxoid Chondrosarcoma of Nasomaxilloethmoid Region with Intracranial Extension: AbstractChondrosarcoma of the faciomaxillary area constitute only 4 % of non-epithelial tumours of the nasal cavity, paranasal sinuses and nasopharynx, making it one of the rare malignancy (Indian J Otolaryngol Head Neck Surg 60(3):284–286, [1]), with its myxoid variety still rarest. It is a slow-growing tumour, occurring mostly in middle-aged men. Primary chondrosarcoma of the nasal and paranasal sinus region, including the nasal septum, rarely extends into the cranial or intracranial areas unless ther...περισσότερα »
Treatment of nausea and vomiting during pregnancy
Treatment of nausea and vomiting during pregnancy —a cross-sectional study among 712 Norwegian women: Abstract PurposeThe purposes of this study were to investigate the treatments used for nausea and vomiting of pregnancy (NVP) according to NVP severity among Norwegian women and to assess whether maternal characteristics and attitudes were related to the use of pharmacological treatment of NVP. MethodsThis is a cross-sectional Web-based study. Pregnant women and mothers with children ≤1 year of age were eligible to participate. Data were collected through an anonymous online que... περισσότερα »
The Importance of Linguistics and Science When Addressing the Social Issues of Residents
The Importance of Linguistics and Science When Addressing the Social Issues of Residents Sir: The recent Special Topic article in *Plastic and Reconstructive Surgery*, “Social Problems in Plastic Surgery Residents: A Management Perspective,”1 brought to mind the importance of choosing one’s words wisely. What is the impact of a single word, “problems,” chosen to represent a group of personal situations? How is the reader’s perception of that word different from the authors’ intent? For many of us, the reaction was a gut one. When reading the abstract, it became evident that, alth...περισσότερα »
Risk of cancer among patients with depressive disorder
Risk of cancer among patients with depressive disorder: a meta-analysis and implications: Abstract Objective The question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder. Methods We searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression base... περισσότερα »
Human papillomavirus genotypes
Prevalence of human papillomavirus genotypes among women with cervical cancer in Ghana: Abstract BackgroundHuman Papillomavirus (HPV) infections have been shown to be a necessary risk factor for the development of cervical cancer. However, HPV genotype distribution varies geographically, both in type and relative prevalence. In order to ensure a successful introduction of available vaccines, there is the need to identify pre-vaccination HPV genotype prevalence in Ghana and the extent of single and multiple-infections. MethodsParaffin-embedded cervical tissues of 256 confirmed ce...περισσότερα »
Combination Radioimmunotherapy Approaches and Quantification of Immuno-PET
Combination Radioimmunotherapy Approaches and Quantification of Immuno-PET: AbstractMonoclonal antibodies (mAbs), which play a prominent role in cancer therapy, can interact with specific antigens on cancer cells, thereby enhancing the patient’s immune response via various mechanisms, or mAbs can act against cell growth factors and, thereby, arrest the proliferation of tumor cells. Radionuclide-labeled mAbs, which are used in radioimmunotherapy (RIT), are effective for cancer treatment because tumor associated-mAbs linked to cytotoxic radionuclides can selectively bind to tumor ant...περισσότερα »
PET/MRI: Technical Challenges and Recent Advances
PET/MRI: Technical Challenges and Recent Advances: AbstractIntegrated positron emission tomography (PET)/magnetic resonance imaging (MRI), which can provide complementary functional and anatomical information about a specific organ or body system at the molecular level, has become a powerful imaging modality to understand the molecular biology details, disease mechanisms, and pharmacokinetics in animals and humans. Although the first experiment on the PET/MRI was performed in the early 1990s, its clinical application was accomplished in recent years because there were various techn...περισσότερα »
Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy
Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy: Abstract To explore the influence of pretreatment lymphopenia on the toxicity and efficacy of first-line chemotherapy in patients with metastatic esophagus squamous cell carcinoma (ESCC). In total, 215 patients were included in this retrospective study. Correlations between pretreatment lymphopenia (lymphocyte count <1 × 109/L) and the occurrence of toxicity and the efficacy of first-line palliative chemot... περισσότερα »
Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer.
[image: http:--highwire.stanford.edu-icons-exter] Authors: Riva G, Raimondo L, Ravera M, Moretto F, Boita M, Potenza I, Rampino M, Ricardi U, Garzaro M Abstract Intensity-modulated radiation therapy (IMRT) for nasopharyngeal cancer (NPC) allowed a better distribution of the dose to the tumor volume, sparing surrounding structures. Aim of the study is the objective evaluation of olfactory and gustatory impairments in patients who underwent chemo-radiotherapy for NPC. Correlation between smell and taste alterations, xerostomy, and radiation technique was investigated. Thirty healthy... περισσότερα »
Association between iron status and thyroid function in children
Association between iron status and thyroid function in Nepalese children: Abstract BackgroundDeficiencies of iodine and iron may have adverse effect on thyroid function. This study was undertaken to investigate the association between iron status and thyroid function in Nepalese children living in hilly regions. MethodsA cross-sectional study was conducted among 227 school children aged 6–12 years living in hilly regions of eastern Nepal. Urine and blood samples were analyzed for urinary iodine concentration, free thyroxine, free triiodothyronine, thyroid stimulating hormone, h... περισσότερα »
For leadership in EU #openaccess, look to the new regulations spearheaded by Dutch presidency https://t.co/XXhg2wgl4M
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
For leadership in EU #openaccess, look to the new regulations spearheaded by Dutch presidency https://t.co/XXhg2wgl4M from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/693029113184018433 via IFTTT
Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy induced neuropathy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Free Radical Biology and Medicine Author(s): Lorenzo Di Cesare Mannelli, Matteo Zanardelli, Ida Landini, Alessandra Pacini, Carla Ghelardini, Enrico Mini, Andrea Bencini, Barbara Valtancoli, Paola Failli BackgrouOne of the most discomfortable dose-limiting adverse reaction of effective drugs for the treatment of solid tumors is a peripheral neuropathy which […]
Physical exercise, reactive oxygen species and neuroprotection
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: Available online 28 January 2016 Source:Free Radical Biology and Medicine Author(s): Zsolt Radak, Katsuhiko Suzuki, Mitsuru Higuchi, Laszlo Balogh, Istvan Boldogh, Erika Koltai Regular exercise has systemic beneficial effects, including the promotion of brain function. The adaptive response to regular exercise involves the up-regulation of the enzymatic antioxidant system and modulation of oxidative […]
Drinking for cops; lawmakers switch seats after fight; escape during Zumba – Arizona Daily Star
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Arizona Daily Star Drinking for cops; lawmakers switch seats after fight; escape during Zumba Arizona Daily Star KANSAS CITY, Mo. (AP) — The Kansas City Police Department announced Thursday that two sergeants and seven detectives in its Crimes Against Children section have been suspended with pay while it investigates claims that some cases haven’t been […]
Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background: Management options for pancreatic neuroendocrine tumors (pNETs) metastatic to the liver include surgical, ablative, cytotoxic, and radioisotope approaches. One potential local treatment option includes selective internal radiotherapy utilizing yttrium-90 (90Y) microspheres. 90Y has also been used in the treatment of hepatocellular carcinoma and tumors metastatic to the liver. It appears to be well tolerated; […]
Slow release coating remedy for nitrogen loss from conventional urea: a review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: 10 March 2016 Source:Journal of Controlled Release, Volume 225 Author(s): Muhammad Yasin Naz, Shaharin Anwar Sulaiman Developing countries are consuming major part of the global urea production with an anticipated nitrogen use efficiency of 20 to 35%. The release of excess nitrogen in the soil is not only detrimental to the environment but […]
The potential of protein–nanomaterial interaction for advanced drug delivery
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: 10 March 2016 Source:Journal of Controlled Release, Volume 225 Author(s): Qiang Peng, Huiling Mu Nanomaterials, like nanoparticles, micelles, nano-sheets, nanotubes and quantum dots, have great potentials in biomedical fields. However, their delivery is highly limited by the formation of protein corona upon interaction with endogenous proteins. This new identity, instead of nanomaterial itself, […]
Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: 10 March 2016 Source:Journal of Controlled Release, Volume 225 Author(s): Yogita Patil, Yasmine Amitay, Patricia Ohana, Hilary Shmeeda, Alberto Gabizon Mitomycin C (MMC) is a powerful anti-bacterial, anti-fungal and anti-tumor antibiotic, often active against multidrug resistant cells. Despite a broad spectrum of antitumor activity, MMC clinical use is relatively limited due to its […]
Zinc finger-inspired nanohydrogels with glutathione/pH triggered degradation based on coordination substitution for highly efficient delivery of anti-cancer drugs
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Publication date: 10 March 2016 Source:Journal of Controlled Release, Volume 225 Author(s): Zihao Zhang, Jiaxun Wan, Luyan Sun, Yongjing Li, Jia Guo, Changchun Wang Biodegradable materials used for drug delivery are of great demand due to their ability to degrade into low molecular weight species and further excrete from the body by metabolism. Herein, we […]
Randomized study of sequential cisplatin-topotecan/carboplatin-paclitaxel versus carboplatin-paclitaxel: effects on quality of life
Randomized study of sequential cisplatin-topotecan/carboplatin-paclitaxel versus carboplatin-paclitaxel: effects on quality of life: Abstract BackgroundA recent phase III trial compared the efficacy of cisplatin-topotecan (a topoisomerase I inhibitor) followed by carboplatin-paclitaxel (Arm 1) versus paclitaxel-carboplatin (Arm 2) in women with newly diagnosed stage IIB or greater ovarian cancer. There was a significantly lower response rate in the experimental arm compared to standard treatment, and less likelihood of normalized CA125 within the first 3 months. At 43 months follo... περισσότερα »
A new once-a-day fentanyl citrate patch (Fentos® Tape)
A new once-a-day fentanyl citrate patch (Fentos® Tape) could be a new treatment option in patients with end-of-dose failure using a 72-h transdermal fentanyl matrix patch: Abstract PurposeThe recommended dosing interval for transdermal fentanyl is every 72 h. However, some patients will have “end-of-dose failure,” which may be seen as an increase of episodes of severe pain flares at the third day after application of the patch. A new once-a-day fentanyl patch was developed in Japan since 2010. This study aimed to assess the efficacy of the once-a-day fentanyl citrate patch for pat... περισσότερα »
Contrast-induced nephropathy in patients with active cancer undergoing contrast-enhanced computed tomography
Contrast-induced nephropathy in patients with active cancer undergoing contrast-enhanced computed tomography: Abstract PurposeThis study was performed to measure the incidence and identify potential predictors of contrast-induced nephropathy (CIN) in cancer patients without chronic kidney disease and with normal or near-normal baseline serum creatinine measures who underwent contrast-enhanced computed tomography (CECT). Severity of CIN was reported based on the RIFLE (risk, injury, failure, loss of kidney function, and end-stage renal disease) classification of acute kidney injury...περισσότερα »
Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.
*Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.* PLoS One. 2016;11(1):e0147682 Authors: Kiessling MK, Curioni-Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, Oldrige DA, Maris JM, Rogler G Abstract High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of patients. However, few inhibitors for the potential treatment for NRAS mutant neuroblastoma have been invest...περισσότερα »
Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21(Cip1/Waf1).
*Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21(Cip1/Waf1).* Cell Death Dis. 2016;7:e2074 Authors: Qiu L, Wu J, Pan C, Tan X, Lin J, Liu R, Chen S, Geng R, Huang W Abstract Dysregulated cell cycle progression has a critical role in tumorigenesis. Cell division cycle 27 (CDC27) is a core subunit of the anaphase-promoting complex/cyclosome, although the specific role of CDC27 in cancer remains unknown. In our study, we explored the biological and clinical significance of CDC27 in colorectal cancer (CRC) growth and progressi...περισσότερα »
Major Gastrointestinal Cancer Resections in the Elderly in India: Poised for Future Challenges.
*Major Gastrointestinal Cancer Resections in the Elderly in India: Poised for Future Challenges.* Dig Surg. 2016 Jan 29;33(2):146-156 Authors: Batra S, Suradkar K, Talole S, Desouza A, Goel M, Shrikhande SV Abstract BACKGROUND: There are no data on surgical outcomes of major gastrointestinal cancer resections in the expanding Indian oncogeriatric population. METHODS: A prospective database of patients who underwent major gastrointestinal cancer resections during varying time periods (2006-2014) was analyzed retrospectively. RESULTS: Two thousand six hundred and forty three patien... περισσότερα »
The Impact of Diabetes on Gynecologic Cancer: Current Status and Future Directions.
*The Impact of Diabetes on Gynecologic Cancer: Current Status and Future Directions.* Curr Obstet Gynecol Rep. 2015 Dec 1;4(4):234-239 Authors: Lees B, Leath CA Abstract Diabetes mellitus has reached epidemic proportions in both the United States and worldwide with most authorities reporting a doubling in the prevalence of diabetes over the last 20-30 years. While this epidemic is closely tied to obesity, diabetes mellitus presents potential clinical challenges over and above that observed with obesity alone. From a women's health care prospective, this rise in diabetes may impa... περισσότερα »
Differential Expression of MicroRNAs in Tissues and Plasma Co-exists as a Biomarker for Pancreatic Cancer.
*Differential Expression of MicroRNAs in Tissues and Plasma Co-exists as a Biomarker for Pancreatic Cancer.* J Cancer Sci Ther. 2015;7(11):336-346 Authors: Ali S, Dubaybo H, Brand RE, Sarkar FH Abstract OBJECTIVE: Pancreatic cancer (PC) is a lethal disease with disappointing results from current treatment modalities, suggesting that novel therapeutic strategies are urgently needed. Since microRNAs (miRNAs) are important player in biology, the clinical utility of miRNAs for designing novel therapeutics is an active area of research. The objective of the present study was to exami... περισσότερα »
Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology.
*Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology.* Analyst. 2016 Jan 28; Authors: Smith BR, Ashton KM, Brodbelt A, Dawson T, Jenkinson MD, Hunt NT, Palmer DS, Baker MJ Abstract Fourier transform infrared (FTIR) spectroscopy has long been established as an analytical technique for the measurement of vibrational modes of molecular systems. More recently, FTIR has been used for the analysis of biofluids with the aim of becoming a tool to aid diagnosis. For the clinician, this represents a convenient, fast, non-subjective ...περισσότερα »
Evidence of increasing public participation in advance care planning: a comparison of polls in Alberta between 2007 and 2013.
*Evidence of increasing public participation in advance care planning: a comparison of polls in Alberta between 2007 and 2013.* BMJ Support Palliat Care. 2016 Jan 27; Authors: Simon JE, Ghosh S, Heyland D, Cooke T, Davison S, Holroyd-Leduc J, Wasylenko E, Howlett J, Fassbender K, Advance Care Planning Collaborative Research and Innovation Opportunities Program (ACP CRIO) Abstract BACKGROUND: Advance care planning (ACP) encompasses both verbal and written communications expressing preferences for future health and personal care and helps prepare people for healthcare decision-maki... περισσότερα »
Emerging Drugs Targeting Human Epidermal Growth Factor Receptor 2 (Her2) In The Treatment Of Breast Cancer.
*Emerging Drugs Targeting Human Epidermal Growth Factor Receptor 2 (Her2) In The Treatment Of Breast Cancer.* Expert Opin Emerg Drugs. 2016 Jan 27; Authors: Awada G, Gombos A, Aftimos P, Awada A Abstract Introduction Human epidermal growth factor 2 (HER2) overexpression is present in 20% of breast cancer patients. It is associated with more aggressive disease and worse clinical outcome. New drugs are thus needed. Approved and future treatments will be discussed in this review. Areas covered The monoclonal antibodies trastuzumab and pertuzumab, the tyrosine kinase inhibitor lapat... περισσότερα »
The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients.
*The effects of hemoglobin levels and their interactions with cigarette smoking on survival in nasopharyngeal carcinoma patients.* Cancer Med. 2016 Jan 28; Authors: Zeng Q, Shen LJ, Li S, Chen L, Guo X, Qian CN, Wu PH Abstract There is very little published information regarding the prognostic value of hemoglobin (Hb) levels combined with smoking on the survival of patients with nasopharyngeal carcinoma (NPC), and the interactions between them remain unclear. A total of 2440 NPC patients were confirmed, and multivariate analysis was performed to identify valuable prognostic Hb l...περισσότερα »
Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Intra-fractional bladder motion and margins in adaptive radiotherapy for urinary bladder cancer.* Acta Oncol. 2015;54(9):1461-6 Authors: Grønborg C, Vestergaard A, Høyer M, Söhn M, Pedersen EM, Petersen JB, Agerbæk M, Muren LP Abstract BACKGROUND: The bladder is a tumour site well suited for adaptive radiotherapy (ART) due to large inter-fractional changes, but it also displays considerable intra-fractional motion. The aim of this study was to assess target coverage with a clinically applied method for plan selection ART an... περισσότερα »
Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation.* Radiat Oncol. 2015;10:50 Authors: Ghadjar P, Budach V, Köhler C, Jantke A, Marnitz S Abstract Young patients with cervical cancer who undergo chemoradiation might be interested in fertility preservation, not only dependent upon the use of a gestational carrier as maybe achieved by the use of ovarian transposition and cryo-conservation of oocytes or ovarian... περισσότερα »
Intensity-modulated Total Body Irradiation (TBI) with TomoDirect™.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Intensity-modulated Total Body Irradiation (TBI) with TomoDirect™.* Radiat Oncol. 2015;10:58 Authors: Salz H, Bohrisch B, Howitz S, Banz N, Weibert K, Wiezorek T, Wendt TG Abstract BACKGROUND: The new TomoDirect™ modality offers a non-rotational option with discrete beam angles. We have investigated this mode for TBI with the intention to test the feasibility and to establish it as a clinical routine method. Special foci were directed onto treatment planning, dosimetric accuracy and pra... περισσότερα »
CAPIRI-IMRT: a phase II study of concurrent capecitabine and irinotecan with intensity-modulated radiation therapy for the treatment of recurrent rectal cancer.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *CAPIRI-IMRT: a phase II study of concurrent capecitabine and irinotecan with intensity-modulated radiation therapy for the treatment of recurrent rectal cancer.* Radiat Oncol. 2015;10:57 Authors: Cai G, Zhu J, Palmer JD, Xu Y, Hu W, Gu W, Cai S, Zhang Z Abstract BACKGROUND: This study investigated the local effect and acute toxicity of irinotecan and capecitabine with concurrent intensity-modulated radiation therapy (IMRT) for the treatment of recurrent rectal cancer without prior pelvi... περισσότερα »
Radiation dose does not influence anastomotic complications in patients with esophageal cancer treated with neoadjuvant chemoradiation and transhiatal esophagectomy.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Radiation dose does not influence anastomotic complications in patients with esophageal cancer treated with neoadjuvant chemoradiation and transhiatal esophagectomy.* Radiat Oncol. 2015;10:59 Authors: Koëter M, van der Sangen MJ, Hurkmans CW, Luyer MD, Rutten HJ, Nieuwenhuijzen GA Abstract BACKGROUND: Neoadjuvant chemoradiation might increase anastomotic leakage and stenosis in patients with esophageal cancer treated with neoadjuvant chemoradiation and esophagectomy. The aim of this stu... περισσότερα »
Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression.
[image: http:--http://ift.tt/1feGv2I] Related Articles *Regulatory circuit of PKM2/NF-κB/miR-148a/152-modulated tumor angiogenesis and cancer progression.* Oncogene. 2015 Oct;34(43):5482-93 Authors: Xu Q, Liu LZ, Yin Y, He J, Li Q, Qian X, You Y, Lu Z, Peiper SC, Shu Y, Jiang BH Abstract Upregulation of the embryonic M2 isoform of pyruvate kinase (PKM2) emerges as a critical player in the cancer development and metabolism, yet the underlying mechanism of PKM2 overexpression remains to be elucidated. Here we demonstrate that IGF-1/IGF-IR regulates PKM2 expression by enhancing HIF... περισσότερα »
Intensive Care Medicine, Vol. 42, Issue 2 - New Issue Alert
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 35 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 01/29/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Intensive Care Medicine*. Volume 42 Number 2 is now available online. Important news Hospitalized patients at risk of dying - call for manuscripts Call for manuscripts on the topic of hospitalized patients at risk of dying. This new call is aimed at both medical and surgical researchers and is open to all specialties. We can fast-track these manuscripts, wi... περισσότερα »
Elderly patients with esophageal squamous cell carcinoma
Multicenter questionnaire survey on patterns of care for elderly patients with esophageal squamous cell carcinoma by the Japan Esophageal Oncology Group: Objective There is little information about the patterns of care for elderly esophageal squamous cell carcinoma patients, and a standardized strategy has not been established. Therefore, we conducted a questionnaire survey about the patterns of care for these patients. Methods On September 2014, the questionnaires were sent to all 43 institutions of the Japan Esophageal Oncology Group, which comprised five parts: (i) definition o...περισσότερα »
Evaluation of Effectiveness and Safety of High-DoseDaptomycin: Results from Patients Included in the European Cubicin® Outcomes Registry and Experience
Evaluation of Effectiveness and Safety of High-Dose Daptomycin: Results from Patients Included in the European Cubicin ® Outcomes Registry and Experience: Abstract IntroductionDaptomycin, a rapid concentration-dependent bactericidal antibiotic, is approved at a dose of 4 mg/kg/day for the treatment of complicated skin and soft tissue infections (cSSTI) and at a dose of 6 mg/kg/day for the treatment of *Staphylococcus aureus* right-sided infective endocarditis (RIE) and bacteremia associated with cSSTI and RIE. Studies have reported the successful use of high-dose daptomycin (>6 mg/kg/day... περισσότερα »
Remote Sensing, Vol. 8, Pages 104: Multi-Class Simultaneous Adaptive Segmentation and Quality Control of Point Cloud Data
3D modeling of a given site is an important activity for a wide range of applications including urban planning, as-built mapping of industrial sites, heritage documentation, military simulation, and outdoor/indoor analysis of airflow. Point clouds, which could be either derived from passive or active imaging systems, are an important source for 3D modeling. Such point clouds need to undergo a sequence of data processing steps to derive the necessary information for the 3D modeling process. Segmentation is usually the first step in the data processing chain. This paper presents a r... περισσότερα »
J. Imaging, Vol. 2, Pages 5: Glidar: An OpenGL-based, Real-Time, and Open Source 3D Sensor Simulator for Testing Computer Vision Algorithms
3D sensors such as lidars, stereo cameras, time-of-flight cameras, and the Microsoft Kinect are increasingly found in a wide range of applications, including gaming, personal robotics, and space exploration. In some cases, pattern recognition algorithms for processing depth images can be tested using actual sensors observing real-world objects. In many situations, however, it is common to test new algorithms using computer-generated synthetic images, as such simulations tend to be faster, more flexible, and less expensive than hardware tests. Computer generation of images is espec... περισσότερα »
C, Vol. 2, Pages 2: Carbon-Doped Hexagonal Boron Nitride: Analysis as π-Conjugate Molecules Embedded in Two Dimensional Insulator
We analyzed the electronic structures of carbon-doped hexagonal boron nitride, focusing on the comparison with the corresponding π-conjugate hydrocarbon molecules and odd-number substitution by first principle calculation. The band gaps are about the half that of the HOMO-LUMO gaps of corresponding hydrocarbons, except for the cis-butadiene structure in which aromatic hexagonal ring formation is important. Odd number doping makes metallic materials with very different work functions, depending upon the difference in B and N numbers, and has an expected application as electrodes fo...περισσότερα »
Proteomes, Vol. 4, Pages 5: The Pollen Coat Proteome: At the Cutting Edge of Plant Reproduction
The tapetum is a single layer of secretory cells which encloses the anther locule and sustains pollen development and maturation. Upon apoptosis, the remnants of the tapetal cells, consisting mostly of lipids and proteins, fill the pits of the sculpted exine to form the bulk of the pollen coat. This extracellular matrix forms an impermeable barrier that protects the male gametophyte from water loss and UV light. It also aids pollen adhesion and hydration and retains small signaling compounds involved in pollen–stigma communication. In this study, we have updated the list of the po... περισσότερα »
Polymers, Vol. 8, Pages 13: Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) Nanofibrous Scaffolds for Tissue Engineering
Biomimetic scaffolds have been investigated in vascular tissue engineering for many years. Excellent biodegradable materials are desired as temporary scaffolds to support cell growth and disappear gradually with the progress of guided tissue regeneration. In the present paper, a series of biodegradable copolymers were synthesized and used to prepared micro/nanofibrous scaffolds for vascular tissue engineering. Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) [P(LA-co-GA-co-MMD)] copolymers with different l-lactide (LA), glycolide (GA), and 3(S)-methyl-2,5-morpholined...περισσότερα »
Insects, Vol. 7, Pages 5: Efficacy of Selected Insecticide Sprays and Aerosols against the Common Bed Bug, Cimex lectularius (Hemiptera: Cimicidae)
We evaluated the residual efficacy of four liquid sprays and four ready-to-use aerosols that are commonly used in the U.S. against a field-collected bed bug, Cimex lectularius L., strain with moderate resistance level to pyrethroids. The four liquid sprays were: Tandem (0.1% thiamethoxam, 0.03% lambda-cyhalothrin), Temprid SC (0.05% imidacloprid, 0.025% cyfluthrin), Transport GHP (0.05% acetamiprid, 0.06% bifenthrin), and Demand CS (0.03% lambda-cyhalothrin). The four aerosols were: Alpine (0.5% dinotefuran), Bedlam (0.4% sumithrin, 1.6% MGK 264), Bedlam Plus (0.4% sumithrin, 1% M...περισσότερα »
Stress-induced visceral pain
Mechanisms of stress-induced visceral pain: implications in irritable bowel syndrome: Abstract Visceral pain describes pain originating from the internal organs of the body and is a common feature of many disorders including irritable bowel syndrome (IBS). Stress is implicated in the development and exacerbation of many visceral pain disorders. Recent evidence suggests that stress and the gut microbiota can interact through complementary or opposing factors to influence visceral nociceptive behaviors. The presentation at this Young Investigator Forum at the International Society of... περισσότερα »
High-cholesterol diet disrupts the levels of hormones derived from anterior pituitary basophilic cells
High-cholesterol diet disrupts the levels of hormones derived from anterior pituitary basophilic cells: Abstract Emerging evidence shows that elevated cholesterol levels are detrimental to health. However, it is unclear whether there is an association between cholesterol and the pituitary. We investigated effects of a high-cholesterol diet on pituitary hormones using *in vivo* animal studies and an epidemiological study. In the animal experiments, rats were fed a high-cholesterol or control diet for 28 weeks. In the rats fed the high-cholesterol diet, the serum levels of thyroid-st... περισσότερα »
The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms
The evaluation of miRNAs on thyroid FNAC: the promising role of miR-375 in follicular neoplasms: AbstractFine needle aspiration cytology (FNAC) plays an essential role in the evaluation of thyroid nodules especially for the category of follicular neoplasms (FN) representing 25 % of all thyroid cases including different neoplastic entities. Hence, one of the most promising areas is the application of molecular tests to FNAC. Among them, microRNAs (miRNA),identified as negative (post-transcriptional) gene expression regulators involved in tumor development, are likely to discriminate... περισσότερα »
The Type 3 Deiodinase is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis
The Type 3 Deiodinase is a Critical Determinant of Appropriate Thyroid Hormone Action in the Developing Testis: Endocrinology, Early Release. Abstract Timely and appropriate levels of thyroid hormone (TH) signaling are necessary to ensure normal developmental outcomes in many tissues. Studies using pharmacological models of altered TH status have revealed an influence of these hormones on testis development and size, but little is known about the role of endogenous determinants of TH action in the developing male gonads. Using a genetic approach, we demonstrate that the type 3 de...περισσότερα »
PROX1 promotes secretory granule formation in medullary thyroid cancer cells
PROX1 promotes secretory granule formation in medullary thyroid cancer cells: Endocrinology, Early Release. Abstract Mechanisms of endocrine secretory granule (SG) formation in thyroid C cells and medullary thyroid cancer (MTC) cells have not been fully elucidated. Here, we directly demonstrated that *PROX1*, a developmental homeobox gene, is transcriptionally involved in SG formation in MTC, which is derived from C cells. Analyses using gene expression databases on websites revealed that, among thyroid cancer cells, MTC cells specifically and highly express *PROX1* as well as se...περισσότερα »
The microbiome and atopic eczema: More than skin deep
The microbiome and atopic eczema: More than skin deep: Abstract Discoveries in the defective molecular composition of the epidermal barrier, such as the epidermal protein filaggrin, in those with atopic eczema (or atopic dermatitis [AD]) have proved crucial in understanding this disease, but its aetiology remains to be fully elucidated. The epidermal barrier is just one interface between the microbial world and our immune system. Recent advances in molecular technology have demonstrated for the first time the true scale of the normal human microbiome and changes seen in disease sta...περισσότερα »
Cutaneous collagenous vasculopathy (CCV) is a rare acquired idiopathic microangiopathy characterised by the progressive development of diffuse asymptomatic telangiectasias over the skin.
Cutaneous collagenous vasculopathy: Report of first Japanese case and review of the literature: Abstract Cutaneous collagenous vasculopathy (CCV) is a rare acquired idiopathic microangiopathy characterised by the progressive development of diffuse asymptomatic telangiectasias over the skin. Histologically, the presence of a thick hyaline collagenous wall around the affected capillaries, comprising the accumulation of collagen type IV, is noted. We herein report the case of a 17-year-old Japanese boy with symmetrical patches of diffuse telangiectasias on the bilateral extremities th... περισσότερα »
Radiation therapy-induced neuro-Sweet disease in a patient with oral squamous cell carcinoma
Radiation therapy-induced neuro-Sweet disease in a patient with oral squamous cell carcinoma: Abstract Neurological involvement is a rare extracutanenous manifestation of Sweet's syndrome. We present a novel case of radiation therapy-induced neuro-Sweet disease in a patient receiving treatment for an oral squamous cell carcinoma.
Multiple invasive squamous cell carcinomas: risk factors and associated increased risk of melanoma and internal malignancies
An Australian cohort of 210 patients with multiple invasive squamous cell carcinomas: risk factors and associated increased risk of melanoma and internal malignancies: Abstract Background Patients with a history of non-melanoma skin cancer (NMSC) have a 50% risk of developing subsequent NMSC.13 Currently there are limited data on the association between multiple squamous cell carcinomas (SCC) and the risk of other cancers, including melanomas. Objective To assess the risk factors in a cohort of 210 Australians with a history of multiple invasive SCC, focusing on the association betw...περισσότερα »
Periorbital Allergic Contact Dermatitis Caused by Lanolin in a Lubricating Eye Ointment
Periorbital Allergic Contact Dermatitis Caused by Lanolin in a Lubricating Eye Ointment:
Immunoglobulin Type Gamma 4-Related Disease Presenting with Cutaneous Plaques
Immunoglobulin Type Gamma 4-Related Disease Presenting with Cutaneous Plaques:
Verrucous melanoma simulating melanoacanthoma
Verrucous melanoma simulating melanoacanthoma: Dermoscopic, reflectance confocal microscopic and high-definition optical coherence tomography presentation of a rare melanoma variant:
Increased thyroid hormone activation accompanies the formation of thyroid hormone dependent negative feedback in developing chicken hypothalamus
Increased thyroid hormone activation accompanies the formation of thyroid hormone dependent negative feedback in developing chicken hypothalamus: Endocrinology, Early Release. Abstract The hypothalamic-pituitary-thyroid (HPT) axis is governed by hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons located in the hypothalamic paraventricular nucleus (PVN) under control of the negative feedback of thyroid hormones. The mechanisms underlying the ontogeny of this phenomenon are poorly understood. We aimed to determine the onset of thyroid hormone-mediated hypotha... περισσότερα »
Selbstverletzungen in der Adoleszenz
Selbstverletzungen in der Adoleszenz: ZusammenfassungSelbstverletzungen treten häufig erstmalig in der Adoleszenz auf. Die diesbezügliche Klassifikation hat aktuell eine erhebliche Neustrukturierung erhalten. Die Einteilung unterscheidet: 1) vorgetäuschte Störungen an sich selbst und anderen, 2) nichtsuizidale Selbstverletzungen sowie 3) Zwangsstörungen und verwandte Störungen. Die Differenzialdiagnosen umfassen ein breites Spektrum psychiatrischer Erkrankungen wie Borderline-Persönlichkeitsstörung, genetische Erkrankungen wie das Lesch-Nyhan-Syndrom oder Körpermodifikationen, wobe... περισσότερα »
The role of separate margins sampling in endoscopic laser surgery for early glottic cancer.
*The role of separate margins sampling in endoscopic laser surgery for early glottic cancer.* Acta Otolaryngol. 2016 Jan 27;:1-6 Authors: Shoffel-Havakuk H, Lahav Y, Davidi ES, Haimovich Y, Hain M, Halperin D Abstract Conclusions Sampling surgical margins in trans-oral laser microsurgery for early glottic squamous cell carcinoma (SCC) may allow for increased local control rate, although with no difference in local control by endoscopic treatment alone. Objective To further delineate the role of routinely sampling separate surgical margins, in patients with early glottic SCC und... περισσότερα »
Analysis on correlation between SP and NK-1R and intranasal mucosal contact point headache.
*Analysis on correlation between SP and NK-1R and intranasal mucosal contact point headache.* Acta Otolaryngol. 2016 Jan 27;:1-6 Authors: Zhao G, Yin J, Peng H, Wang J Abstract Conclusion Distribution of SP and NK-1R, especially NK-1R, in nasal mucosal tissue at contact point was higher compared with non-contact point. It was suggested that SP and NK-1R were associated with mucosal contact point headache. Objectives To observe difference of substance P (SP) and NK-1 receptor (NK-1R) expression in tissues at contact point and non-contact point among the patients with intranasal m...περισσότερα »
[Lymphatic malformations in the head and neck area].
*[Lymphatic malformations in the head and neck area].* HNO. 2016 Jan 28; Authors: Wiegand S, Werner JA Abstract Lymphatic malformations are congenital malformations of the lymphatic system. They are mainly located in the head and neck area, and grow proportional to the patients' body growth. Depending on the morphology, it can be distinguished between macrocystic, microcystic and mixed lymphatic malformations. Due to their infiltrative growth, microcystic lymphatic malformations are particularly difficult to treat. Therapeutic approaches include conventional surgical resection, ...περισσότερα »
The role of separate margins sampling in endoscopic laser surgery for early glottic cancer.
*The role of separate margins sampling in endoscopic laser surgery for early glottic cancer.* Acta Otolaryngol. 2016 Jan 27;:1-6 Authors: Shoffel-Havakuk H, Lahav Y, Davidi ES, Haimovich Y, Hain M, Halperin D Abstract Conclusions Sampling surgical margins in trans-oral laser microsurgery for early glottic squamous cell carcinoma (SCC) may allow for increased local control rate, although with no difference in local control by endoscopic treatment alone. Objective To further delineate the role of routinely sampling separate surgical margins, in patients with early glottic SCC und... περισσότερα »
Analysis on correlation between SP and NK-1R and intranasal mucosal contact point headache.
*Analysis on correlation between SP and NK-1R and intranasal mucosal contact point headache.* Acta Otolaryngol. 2016 Jan 27;:1-6 Authors: Zhao G, Yin J, Peng H, Wang J Abstract Conclusion Distribution of SP and NK-1R, especially NK-1R, in nasal mucosal tissue at contact point was higher compared with non-contact point. It was suggested that SP and NK-1R were associated with mucosal contact point headache. Objectives To observe difference of substance P (SP) and NK-1 receptor (NK-1R) expression in tissues at contact point and non-contact point among the patients with intranasal m...περισσότερα »
Ocular vestibular evoked myogenic potentials to vertex low frequency vibration as a diagnostic test for superior canal dehiscence.
*Ocular vestibular evoked myogenic potentials to vertex low frequency vibration as a diagnostic test for superior canal dehiscence.* Clin Neurophysiol. 2016 Jan 12; Authors: Verrecchia L, Westin M, Duan M, Brantberg K Abstract OBJECTIVE: To explore ocular vestibular evoked myogenic potentials (oVEMP) to low-frequency vertex vibration (125Hz) as a diagnostic test for superior canal dehiscence (SCD) syndrome. METHODS: The oVEMP using 125Hz single cycle bone-conducted vertex vibration were tested in 15 patients with unilateral superior canal dehiscence (SCD) syndrome, 15 healthy con... περισσότερα »
Vestibular Disorders in Children With Congenital Cytomegalovirus Infection.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Vestibular Disorders in Children With Congenital Cytomegalovirus Infection.* Pediatrics. 2015 Oct;136(4):e887-95 Authors: Bernard S, Wiener-Vacher S, Van Den Abbeele T, Teissier N Abstract BACKGROUND: Congenital cytomegalovirus (CMV) infection is the leading infectious cause of neurologic disabilities and sensorineural hearing loss in children. Sensorineural hearing loss prevalence in CMV suggests a viral tropism for the inner ear. Vestibular disorders induced by CMV infection are underestimated. This is the larg...περισσότερα »
Life-Threatening Retropharyngeal Hemorrhage Secondary to Rupture of the Inferior Thyroid Artery.
*Life-Threatening Retropharyngeal Hemorrhage Secondary to Rupture of the Inferior Thyroid Artery.* Case Rep Emerg Med. 2015;2015:789076 Authors: Calogero CG, Miller AC, Greenberg MR Abstract Inferior thyroid artery (ITA) rupture is rare and may progress to life-threatening conditions. We present a patient who visited the emergency department after an episode of syncope and dizziness in which he had a mechanical fall that resulted in abrasions and a hematoma to his left forehead. The patient presented with dysphagia and anterior neck swelling that progressed rapidly into airway c... περισσότερα »
Cancer Incidence in Appalachia, 2004-2011.
*Cancer Incidence in Appalachia, 2004-2011.* Cancer Epidemiol Biomarkers Prev. 2016 Jan 27; Authors: Wilson RJ, Ryerson AB, Singh SD, King JB Abstract BACKGROUND: Limited literature is available about cancer in the Appalachian Region. This is the only known analysis of all cancers for Appalachia and non-Appalachia covering 100% of the US population. Appalachian cancer incidence and trends were evaluated by state, sex, and race and compared with those found in non-Appalachian regions. METHODS: US counties were identified as Appalachian or non-Appalachian. Age-adjusted cancer incid... περισσότερα »
Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study.
*Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study.* Cancer Med. 2016 Jan 27; Authors: Chen D, Gong L, Jiang Q, Wang X, Zhang B Abstract A previous study indicated that MLL3 genetic polymorphisms were associated with human cancer. However, whether MLL3 genetic variants are associated with the risk of laryngeal cancer is not clear. This study investigated the association between MLL3 gene polymorphisms and laryngeal cancer in a Chinese population. Four polymorphisms of the MLL3 gene (rs6943984, rs4725443, rs380... περισσότερα »
Heterozygosity for a Novel Missense Mutation in the ITGB4 Gene Associated With Autosomal Dominant Epidermolysis Bullosa.
*Heterozygosity for a Novel Missense Mutation in the ITGB4 Gene Associated With Autosomal Dominant Epidermolysis Bullosa.* JAMA Dermatol. 2016 Jan 27; Authors: Turcan I, Pasmooij AM, van den Akker PC, Lemmink H, Halmos GB, Sinke RJ, Jonkman MF Abstract Importance: Epidermolysis bullosa (EB) is a group of mechanobullous genodermatoses characterized by the fragility of skin and mucous membranes. Mutations in the ITGA6 and ITGB4 genes, encoding the hemidesmosomal protein α6β4-integrin, have been involved in the pathogenesis of EB. To date, the inheritance of these particular genes ... περισσότερα »
Paediatric melanoma
Single institution experience of paediatric melanoma in Victoria, Australia: Abstract Background/Objectives Paediatric melanoma is an uncommon presentation of melanoma that accounts for 3% of all paediatric cancers. The objective was to describe a series of paediatric melanoma cases presenting to a state-wide tertiary referral service over the past 19 years. Methods A search of the Victorian Melanoma Service database was performed to identify all patients under the age of 20 years diagnosed with melanoma from 1994 to 2013. Histological, demographic and phenotypical information for ...περισσότερα »
Performance of primary repair on colon injuries sustained by low versus high-energy projectiles
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Association between increased blood interleukin-6 levels on emergency department arrival and prolonged length of intensive care unit stay for blunt trauma
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Postoperative radiographs after open reduction and internal fixation of mandibular fractures: Clinical need or unnecessary radiation?
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Inflammatory markers following resuscitation from out-of-hospital cardiac arrest - a prospective multicenter observational study
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Plasma calprotectin level: usage in distinction of uncomplicated from complicated acute appendicitis
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Tracheal tube position shift during infant resuscitation by chest compression: a simulation comparison by fixation method and with or without cuff
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Long-term neurologic outcomes following paediatric out-of-hospital cardiac arrest
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Resuscitators who compared four simulated infant cardiopulmonary resuscitation methods favoured the three to one compression to ventilation ratio
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Comparison of the results of laparoscopic appendectomies with application of different techniques for closure of the appendicular stump
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A randomised controlled trial of cognitive aids for emergency airway equipment preparation in a Paediatric Emergency Department
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Krebs und Lebensstil
Krebs und Lebensstil: ZusammenfassungDie stetig wachsende Zahl an Patienten, die ihre Krebserkrankung überleben (Langzeitüberlebende), und deren spezielle Lebenssituationen bedingen einen zunehmenden Bedarf an Beratungen zu den Themen Lebensqualität und Rezidivprophylaxe. Diese Beratung ist häufig mit Aspekten der komplementären Medizin oder auch sozialmedizinischen Aspekten vergesellschaftet. In der Langzeitbetreuung von Patienten gewinnt sie zunehmend an Bedeutung. In diesem Beitrag werden die wissenschaftlich gesicherten Erkenntnisse zu den Aspekten Ernährung, Sport, Nikotinabus... περισσότερα »
Facial Skin Lesions in Children Caused by Nontuberculous Mycobacteria
Facial Skin Lesions in Children Caused by Nontuberculous Mycobacteria: Abstract Background Nontuberculous mycobacteria rarely cause facial skin lesions in immunocompetent children. Aim I describe the clinical features and treatment of nontuberculous mycobacteria facial lesions. Materials and Methods The diagnosis of a facial nontuberculous mycobacteria infection was established using polymerase chain reaction. Results Of 286 children with confirmed nontuberculous mycobacteria infection, 14 (4.9%; median age 50 mos, range 9–156 mos; 5 [36%] male, 9 [64%] female) had nontuberculous myc... περισσότερα »
Erythrosis Pigmentosa Peribuccalis in an Adolescent
Erythrosis Pigmentosa Peribuccalis in an Adolescent: Dermoscopic Description and Management: Abstract Erythrosis pigmentosa peribuccalis is an infrequent condition, with fewer than 35 cases reported in the literature, that affects mainly women. It presents as small papules that form a hyperpigmented plaque around the mouth and nose. Little is known about the etiology of this condition, its dermoscopic characteristics have not been described, and no effective treatment has been reported. We report a 15-year-old girl with this rare dermatosis who was successfully managed with daily c... περισσότερα »
Eczema Herpeticum
Validation of database search strategies for the epidemiological study of eczema herpeticum: Abstract Eczema herpeticum (EH) is characterized by viral infection of a preexisting inflammatory dermatosis. EH is associated with considerable morbidity and even mortality. It is important to study EH, in order to identify risk factors and burden of disease. Yet, the epidemiology of EH has not been well defined. To our knowledge, large-scale population-based studies that examined the epidemiology of EH have not been reported. Previous studies of risk factors for EH have been mostly limite... περισσότερα »
Atopic dermatitis is not associated with actinic keratosis
Atopic dermatitis is not associated with actinic keratosis: cross-sectional results from the Rotterdam study: Abstract Background Epidermal barrier impairment and altered immune system in atopic dermatitis (AD) may predispose to ultraviolet induced DNA damage. Objective To study the association between atopic dermatitis and actinic keratosis (AK) in a population-based cross-sectional study. Methods AD was defined by modified criteria of the U.K. working party's diagnostic criteria. The AKs were diagnosed by physicians during a full-body skin examination and keratinocyte cancers were ... περισσότερα »
Segmental Basal cell nevus syndrome caused by an activating mutation in Smoothened
Segmental Basal cell nevus syndrome caused by an activating mutation in Smoothened: Abstract Aberrant sonic hedgehog signaling, mostly due to *PTCH1* mutations, has been shown to play a central role in the pathogenesis of basal cell carcinoma (BCC), as well as in Basal Cell Nevus Syndrome (BCNS). Mutations in Smoothened *(SMO)* encoding a receptor for sonic hedgehog, have been reported in sporadic BCCs but not in BCNS. We report a case with multiple BCCs, pits and comedones in a segmental distribution over the upper part of the body, along with other findings compatible with BCNS. ... περισσότερα »
Squamous cell carcinoma antigen (SCCA) belongs to the ovalbumin–serpin family and is a known tumour marker. Expression of SCCA is up-regulated in serum and skin of psoriasis patients.
Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment: Abstract Background Squamous cell carcinoma antigen (SCCA) belongs to the ovalbumin–serpin family and is a known tumour marker. Expression of SCCA is up-regulated in serum and skin of psoriasis patients. Objectives The aim of this study was to determine SCCA2 levels in association with disease severity and treatment efficacy in patients with psoriasis. Methods One hundred twenty-three psoriasis patients and 25 healthy controls were enroll...περισσότερα »
Subcutaneous Fat Necrosis of the Neonate with Subsequent Delayed-Onset Skin Eruption
Subcutaneous Fat Necrosis of the Neonate with Subsequent Delayed-Onset Skin Eruption: Abstract Subcutaneous fat necrosis (SCFN) of the neonate is a rare panniculitis of early life that occurs in association with gestational diabetes and preeclampsia, as well as perinatal asphyxia, hypothermia, and trauma. A characteristic feature of this condition is its self-limiting and monophasic nature. We report a highly unusual case of delayed SCFN in a male neonate involving an anatomically discrete eruption, reminiscent of erythema nodosum, occurring many weeks after his original eruption h...περισσότερα »
Erythema ab igne (EAI), a benign, reticular, erythematous dermatosis caused by repeated prolonged skin exposure to mild heat
Erythema Ab Igne in Three Girls with Anorexia Nervosa: Abstract We present three girls with the eating disorder anorexia nervosa (AN) presenting with erythema ab igne (EAI), a benign, reticular, erythematous dermatosis caused by repeated prolonged skin exposure to mild heat. AN has been associated with abnormal peripheral vascular response to cold, vasoconstriction of the limbs, low hand blood flow, exaggerated response to cold stimuli, subnormal core temperature, and a general feeling of cold that may encourage prolonged heat exposure and induce EAI.
Congenital Panfollicular Nevus in a 6-Month-Old Girl
Congenital Panfollicular Nevus in a 6-Month-Old Girl: Abstract A 6-month-old girl presented with an irregular nodule on the right lateral neck. The lesion, which superficially resembled a lymphangioma or mastocytoma, had been present since birth but had recently been growing. The patient was referred for surgical resection. Microscopic findings were compatible with a recently described rare hamartoma termed “panfollicular nevus,” which is a well-circumscribed lesion containing aberrantly differentiated, clustered hair follicles in high density.
The Folded Ulnar Forearm Flap for Nasal Reconstruction
The Folded Ulnar Forearm Flap for Nasal Reconstruction: [image: image] Background: Many strategies exist to reconstruct composite nasal defects, but free flaps are necessary for extensive defects. The workhorse radial forearm flap is hair-bearing and donor-site cosmesis is unfavorable. The ulnar forearm flap is overlooked despite important aesthetic benefits. The authors describe their experience with the ulnar forearm flap, with a novel folding technique in staged nasal reconstruction. Methods: Between December of 2010 and April of 2015, 10 nasal reconstructions in five men and fiv... περισσότερα »
Determining the Duration of Leech Therapy in the Treatment of Acute Venous Congestion in Prefabricated Free Flaps
Determining the Duration of Leech Therapy in the Treatment of Acute Venous Congestion in Prefabricated Free Flaps: [image: image] Sir: Currently, there are no guidelines to determine the minimal time required to leech a congested prefabricated flap. We present a case of a prefabricated free flap successfully leeched for 54 hours and comment on the physiological basis for the duration of therapy. An 8-year-old girl presented with a severe neck burn contracture 2 years after sustaining an 80 percent total body burn. The only unburned skin was on the lateral aspect of her left t... περισσότερα »
Treatment Outcome of the Transfacial Titanium Epiplating System for Total Nasal Defects
Treatment Outcome of the Transfacial Titanium Epiplating System for Total Nasal Defects: [image: image]Background: Malignant tumors are the most frequent reason for acquired defects of the nose. Bone-anchored craniofacial prostheses represent a secure, uncomplicated, and cosmetically acceptable rehabilitative alternative to surgical reconstruction. The aim of this study was to determine a potential benefit of the Titanium Epiplating System (Fa. Medicon, Tuttlingen, Germany) as a grouped implant system in the anatomically difficult nasal region with limited bone supply. Methods: Patie... περισσότερα »
Chronic Osteomyelitis of the Manubrio-Clavicular Joint following Breast Augmentation
Chronic Osteomyelitis of the Manubrio-Clavicular Joint following Breast Augmentation: [image: image] We present the case of a 55-year-old white woman who presented with painful right sternoclavicular joint destruction secondary to osteomyelitis, following subpectoral saline breast augmentation. The initial breast augmentation was complicated by implant deflation, which was managed with implant replacement. Consequently, the patient developed two episodes of right breast infection, which necessitated implant removal. Cultures from the first infection were positive for *Pseudomon... περισσότερα »
Preoperative Computed Tomography–Guided Virtual Surgical Planning for Osteocutaneous Free Flap Mandible Reconstruction
Discussion: Long-Term Operative Outcomes of Preoperative Computed Tomography–Guided Virtual Surgical Planning for Osteocutaneous Free Flap Mandible Reconstruction: [image: image]
Unusual large functional adrenocortical carcinoma in a young woman
Description A 27-year-old woman presented with an abdominal lump and features of Cushing syndrome with virilisation, namely, weight gain, acne, hyperpigmentation, hirsutism, central obesity, rounded face, stretch marks, osteoporosis, dyslipidaemia, hypertension and amenorrhoea (figure 1). Serum testosterone and cortisol levels were elevated. Oestradiol and 24 h urinary metanephrine were within normal range. contrast-enhanced CT of the abdomen showed a right supra renal mass measuring 9.5x8.3x5.5 cm (figure 2). The clinical diagnosis was adrenocortical carcinoma (ACC). The left ad...περισσότερα »
Ureteric lymphoma as a rare cause of right lower ureteric obstruction
Primary lymphoid neoplasms of the urinary tract are exceedingly rare, with only 21 cases being reported and comprising less than 5% of all primary extranodal lymphomas. We report a case of a 45-year-old man who presented with right flank pain and weight loss, and who was found to have a stricture in the right lower ureter causing ureteral obstruction. Histopathology revealed lower ureteric non-Hodgkin lymphoma, which, on further evaluation, was found to be isolated ureteric lymphoma. The patient was doing well after six cycles of R-CHOP chemotherapy. This case is being reported as...περισσότερα »
Successful pregnancy with autoimmune cirrhosis
Pregnancy with liver cirrhosis is a rare and dangerous event that exposes mother and fetus to potentially lethal risks. During pregnancy, hepatic decompensation could suffice and the development of hepatic failure and encephalopathy could occur. The incidence of obstetric complications is also increased with a high rate of pre-eclampsia, postpartum bleeding, preterm delivery and stillbirth. We report a case of a 27-year-old woman with autoimmune hepatitis and liver cirrhosis complicated by splenomegaly, oesophageal varices and severe thrombocytopaenia. During pregnancy, close clin... περισσότερα »
Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine
A 14-year-old girl who was known to have a seizure disorder and on lamotrigine treatment was admitted to the hospital, with a history of rash, fever and cough. Her condition deteriorated with clinical features suggestive of anticonvulsant hypersensitivity syndrome (ACHS) complicated with bronchiolitis obliterans organising pneumonia (BOOP). Her chest CT showed multifocal parenchymal opacities and lung biopsy was typical for BOOP. Initially, the lamotrigine was discontinued since the onset of the rash, then she was treated for pneumonia with antibiotics, which may have delayed the ...περισσότερα »
Bericht zum 9. ASA TCM-Kongress in Solothurn: Thema «Wandlungsphase Feuer»
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Schweiz Z Ganzheitsmed 2016;28:23-25 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PmNYeN via IFTTT
Early HIV treatment to forestall drug resistance
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 29 January 2016 Source:The Lancet Infectious Diseases Author(s): Mark A Wainberg from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nslZzm via IFTTT
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 29 January 2016 Source:The Lancet Infectious Diseases Author(s): The TenoRes Study Group BackgroundAntiretroviral therapy (ART) is crucial for controlling HIV-1 infection through wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir disoproxil fumarate-containing regimens are increasingly used to treat and prevent HIV, although few data exist for frequency and risk […]
New molecular profiling for glioma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Novel, more accurate classification for brain tumors may open new therapeutic targets and help physicians to choose treatment. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PJpQ80 via IFTTT
Scientists decode brain signals nearly at speed of perception
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Using electrodes implanted in the temporal lobes of awake patients, scientists have decoded brain signals at nearly the speed of perception. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PJpPB3 via IFTTT
Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Management options for pancreatic neuroendocrine tumors (pNETs) metastatic to the liver include surgical, ablative, cytotoxic, and radioisotope approaches. One potential local treatment option includes selective internal radiotherapy utilizing yttrium-90 (90Y) microspheres. 90Y has also been used in the treatment of hepatocellular carcinoma and tumors metastatic to the liver. It appears to be well tolerated; […]
Unusual large functional adrenocortical carcinoma in a young woman
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Description A 27-year-old woman presented with an abdominal lump and features of Cushing syndrome with virilisation, namely, weight gain, acne, hyperpigmentation, hirsutism, central obesity, rounded face, stretch marks, osteoporosis, dyslipidaemia, hypertension and amenorrhoea (figure 1). Serum testosterone and cortisol levels were elevated. Oestradiol and 24 h urinary metanephrine were within normal range. contrast-enhanced CT of […]
Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer.
Related Articles Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer. Chem Senses. 2015 May;40(4):285-92 Authors: Riva G, Raimondo L, Ravera M, Moretto F, Boita M, Potenza I, Rampino M, Ricardi U, Garzaro M Abstract Intensity-modulated radiation therapy (IMRT) for nasopharyngeal cancer (NPC) allowed a better distribution of the dose to the tumor volume,… Continue reading Late sensorial alterations in different radiotherapy techniques for nasopharyngeal cancer.
Brèves de l’AERIO
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Buchbesprechungen
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Odor-cued taste avoidance: a simple and robust test of mouse olfaction.
Related Articles Odor-cued taste avoidance: a simple and robust test of mouse olfaction. Chem Senses. 2015 May;40(4):269-78 Authors: Slotnick B, Coppola DM Abstract In odor-cued taste avoidance (OCTA), thirsty mice, offered either an odorized nonaversive fluid (S+) or an odorized aversive fluid (S-), quickly learn to use odor to avoid drinking the S-. Acquisition of… Continue reading Odor-cued taste avoidance: a simple and robust test of mouse olfaction.
Editorial Board / Inhalt / Impressum / Hinweise für Autoren
Schweiz Z Ganzheitsmed 2016;28:1-3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PmOBF0 via IFTTT
Long-term memory for odors: influences of familiarity and identification across 64 days.
Related Articles Long-term memory for odors: influences of familiarity and identification across 64 days. Chem Senses. 2015 May;40(4):259-67 Authors: Cornell Kärnekull S, Jönsson FU, Willander J, Sikström S, Larsson M Abstract Few studies have investigated long-term odor recognition memory, although some early observations suggested that the forgetting rate of olfactory representations is slower than for… Continue reading Long-term memory for odors: influences of familiarity and identification across 64 days.
Bildungsmarkt
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Obese individuals have higher preference and sensitivity to odor of chocolate.
Related Articles Obese individuals have higher preference and sensitivity to odor of chocolate. Chem Senses. 2015 May;40(4):279-84 Authors: Stafford LD, Whittle A Abstract The worldwide epidemic of obesity has inspired a great deal of research into its causes and consequences. It is therefore surprising that so few studies have examined such a fundamental part of… Continue reading Obese individuals have higher preference and sensitivity to odor of chocolate.
Mitteilungen UNION
Schweiz Z Ganzheitsmed 2016;28:55 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1P1BpSx via IFTTT
The genetic basis for variation in olfactory behavior in Drosophila melanogaster.
Related Articles The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Chem Senses. 2015 May;40(4):233-43 Authors: Arya GH, Magwire MM, Huang W, Serrano-Negron YL, Mackay TF, Anholt RR Abstract The genetic underpinnings that contribute to variation in olfactory perception are not fully understood. To explore the genetic basis of variation in olfactory perception,… Continue reading The genetic basis for variation in olfactory behavior in Drosophila melanogaster.
Long-Term Operative Outcomes of Preoperative Computed Tomography–Guided Virtual Surgical Planning for Osteocutaneous Free Flap Mandible Reconstruction
Long-Term Operative Outcomes of Preoperative Computed Tomography–Guided Virtual Surgical Planning for Osteocutaneous Free Flap Mandible Reconstruction: [image: image] Background: Osteocutaneous free flaps have become the primary reconstructive modality for segmental mandibulectomy defects. The advent of preoperative virtual surgical planning with stereolithic models and cutting templates has led to significant refinements in operative technique. In this article, the authors examine the value of computed tomography–guided preoperative virtual surgical planning on operative outcomes ... περισσότερα »
Surgeon Reimbursements in Maxillofacial Trauma Surgery: Effect of the Affordable Care Act in Ohio
Surgeon Reimbursements in Maxillofacial Trauma Surgery: Effect of the Affordable Care Act in Ohio: [image: image]Background: Surgical treatment of maxillofacial injuries has historically been associated with low reimbursements, mainly because of the high proportion of uninsured patients. The Affordable Care Act, implemented in January of 2014, aimed to reduce the number of uninsured. If the Affordable Care Act achieves this goal, surgeons may benefit from improved reimbursement rates. The authors’ purpose was to evaluate the effects of the Affordable Care Act on payor distribution a...περισσότερα »
Financial Conflicts of Interest in Plastic Surgery: Background, Potential for Bias, Disclosure, and Transparency
Financial Conflicts of Interest in Plastic Surgery: Background, Potential for Bias, Disclosure, and Transparency Sir: In his recent Special Topics article, Dr. Ed Luce explores two important issues.1 First, he offers a more detailed standard for reporting financial relationships that could be considered as conflicts of interest for authors with such relationships. Second, he proposes complex regulations limiting individuals with such relationships from participating in peer review, presentations, and publication within academic circles. These two topics can be summarized as discl... περισσότερα »
Continuous Positive Airway Pressure for Upper Airway Obstruction in Infants with Pierre Robin Sequence
Continuous Positive Airway Pressure for Upper Airway Obstruction in Infants with Pierre Robin Sequence: [image: image]Summary: The aim of the study was to evaluate noninvasive continuous positive airway pressure as first-line treatment for upper airway obstruction in neonates with Pierre Robin sequence. Forty-four neonates were enrolled and classified in 4 groups: ventilator-dependent patients (severe upper airway obstruction group), patients with clinical upper airway obstruction, an abnormal (moderate upper airway obstruction group) or normal polygraphy (mild upper airway obstruct... περισσότερα »
Technology and Plastic Surgery: Potential Pitfalls for Patient Confidentiality and Proposed Solutions
Technology and Plastic Surgery: Potential Pitfalls for Patient Confidentiality and Proposed Solutions Sir: We read with great interest the article by Patel et al. entitled “Technology and Plastic Surgery: Potential Pitfalls for Patient Confidentiality and Proposed Solutions.”1 The authors are to be congratulated for their interest in patient confidentiality and the proposed solutions to secure protected health information. In our study of the use of photography conducted with 176 plastic surgeons,2 the surgeons often shared their photographs with others surgeons (71.1 percent) an... περισσότερα »
Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis
Time Interval Reduction for Delayed Implant-Based Cranioplasty Reconstruction in the Setting of Previous Bone Flap Osteomyelitis: [image: image]Background: Reinfections following implant-based cranioplasty, in the setting of previous bone flap osteomyelitis, are common and associated with significant morbidity. The timing of reconstruction following initial osteomyelitic bone flap removal remains controversial; most advocate for prolonged time intervals of approximately 6 to 12 months. Thus, the authors investigated their delayed cranioplasty outcomes following both early (between 9... περισσότερα »
Biomechanical and Safety Testing of a Simplified Negative-Pressure Wound Therapy Device
Reply: Biomechanical and Safety Testing of a Simplified Negative-Pressure Wound Therapy Device Sir: We appreciate the interest and questions from Drs. Xue and Zhao regarding our report on the biomechanical performance of a mechanically powered, simplified negative-pressure wound therapy device. For purposes of the phase I trial, our inclusion criteria included wound sizes from 2 to 150 cm2, to reduce variability in wound characteristics and allow an analysis of the device’s performance. However, in clinical practice, the simplified negative-pressure wound therapy device can be ap... περισσότερα »
Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction
Anticoagulation for Hypercoagulable Patients Associated with Complications after Large Cranioplasty Reconstruction: Background: Despite advancements in materials and techniques used for cranial reconstruction, complication rates following reconstructive cranioplasty remain significant. Methods: In this study, the authors assessed the association of perioperative anticoagulation use and/or a hypercoagulable state with minor (i.e., not requiring surgical intervention) and major (i.e., surgical intervention required) complications after reconstructive cranioplasty for large skull defe... περισσότερα »
Contemporary Solutions for the Treatment of Facial Nerve Paralysis
Contemporary Solutions for the Treatment of Facial Nerve Paralysis Sir: We read with great interest the CME article entitled “Contemporary Solutions for the Treatment of Facial Nerve Paralysis” by Garcia et al. published in June of 2015.1 The authors have succinctly described contemporary procedures for restoration of facial animation, but we would like to bring to your notice some of our own observations and experience that may help in complementing this CME article. Because this CME article was summarizing current concepts in facial reanimation, possibly targeting trainees, we f... περισσότερα »
Craniofacial Fracture Patterns
Defining Population-Specific Craniofacial Fracture Patterns and Resource Use in Geriatric Patients: A Comparative Study of Blunt Craniofacial Fractures in Geriatric versus Nongeriatric Adult Patients: Background: This study investigates the hypothesis that mechanisms of injury, fracture patterns, and burden to the health care system differ between geriatric and nongeriatric populations sustaining blunt-force craniofacial trauma. Methods: A 5-year retrospective chart review of patient records and computed tomographic imaging was performed. Demographic and outcome data were extracted f...περισσότερα »
Facial Fractures in the Aging Population
Facial Fractures in the Aging Population: [image: image]Background: As the U.S. population ages and life expectancy increases, the number of elderly patients seeking trauma care and treatment for facial fractures will increase. Understanding age-related differences in the pattern, cause, and management of these fractures is essential for improving care. Methods: A retrospective review of adults presenting to a Level I trauma center was performed to evaluate age-related differences in facial fractures. Descriptive statistics were used to compare fracture number, type, cause of injury,... περισσότερα »
Long-Term Results of Mandibular Distraction Osteogenesis with a Resorbable Device in Infants with Robin Sequence: Effects on Developing Molars and Mandibular Growth
Long-Term Results of Mandibular Distraction Osteogenesis with a Resorbable Device in Infants with Robin Sequence: Effects on Developing Molars and Mandibular Growth: [image: image] Background: Mandibular distraction osteogenesis with a unidirectional resorbable device is an effective treatment option for severe upper airway obstruction in infants with Robin sequence. Long-term effects, especially with regard to tooth development and mandibular outgrowth, are not known. Methods: Robin sequence infants with a follow-up of greater than or equal to 5 years were included. Baseline charac...περισσότερα »
Long-Term Computed Tomographic Evaluation of Alveolar Bone Formation in Patients with Unilateral Cleft Lip and Palate after Early Secondary Gingivoalveoloplasty
Long-Term Computed Tomographic Evaluation of Alveolar Bone Formation in Patients with Unilateral Cleft Lip and Palate after Early Secondary Gingivoalveoloplasty: [image: image] Background: The goal of this study was to evaluate with a three-dimensional method the long-term quality of alveolar ossification in unilateral cleft lip and palate patients who underwent early secondary gingivoalveoloplasty according to the Milan surgical protocol. Methods: The sample consisted of 63 computed tomographic scans of unilateral cleft lip and palate patients in permanent dentition. The average a... περισσότερα »
Antibiotic Use in Primary Palatoplasty: A Survey of Practice Patterns, Assessment of Efficacy, and Proposed Guidelines for Use
Antibiotic Use in Primary Palatoplasty: A Survey of Practice Patterns, Assessment of Efficacy, and Proposed Guidelines for Use: [image: image]Background: The literature provides no guidelines for antibiotic use in palatoplasty. The authors sought to ascertain practice patterns; review a large, single-surgeon experience, and propose guidelines for antibiotic use in primary palatoplasty. Methods: A six-question survey was e-mailed to all surgeons of the American Cleft Palate-Craniofacial Association. A retrospective study was also conducted of the senior author’s 10-year primary palato... περισσότερα »
Utility of Tongue Stitch and Nasal Trumpet in the Immediate Postoperative Outcome of Cleft Palatoplasty
Utility of Tongue Stitch and Nasal Trumpet in the Immediate Postoperative Outcome of Cleft Palatoplasty: [image: image]Background: Postoperative airway obstruction is a feared complication following cleft palate repair. The aim of this study was to evaluate the effectiveness of tongue stitches and nasal trumpets that have been used in an attempt to prevent this complication. Methods: An 8-year (2005 to 2013) retrospective review of palatoplasties performed at a tertiary care center was conducted. Patients were divided into three groups: those with no airway protective measure, those ...περισσότερα »
Sutureless Microsurgical Anastomosis Using an Optimized Thermoreversible Intravascular Poloxamer Stent
Sutureless Microsurgical Anastomosis Using an Optimized Thermoreversible Intravascular Poloxamer Stent: [image: image]Background: Sutureless microvascular anastomosis has great translational potential to simplify microvascular surgery, shorten operative times, and improve clinical outcomes. The authors developed a transient thermoreversible microvascular stent using a poloxamer to maintain vessel lumen patency before application of commercially available adhesives to seal the anastomosis instead of sutures. Despite technical success, human application necessitates bovine serum album... περισσότερα »
So You Have a Research Idea
So You Have a Research Idea: A Survey of Databases Available for Plastic Surgery Research: [image: image]Summary: Plastic surgery research using large databases has increased dramatically over the past 20 years. With the magnitude and breadth of information available in these databases, researchers are able to more easily answer a wide variety of research questions. This study sought to provide a comprehensive comparative analysis of the relevant databases for plastic surgery research. Database information, data collection methods, acquisition details, and variable availability were... περισσότερα »
An Examination of Differences in the New Bone Formation Promoted by Different Doses of Recombinant Human Parathyroid Hormone during Mandibular Distraction Osteogenesis
An Examination of Differences in the New Bone Formation Promoted by Different Doses of Recombinant Human Parathyroid Hormone during Mandibular Distraction Osteogenesis: [image: image]Background: The administration of different doses of parathyroid hormone to promote mandibular distraction osteogenesis remains unclear. The objective of the present study was to examine the effects of recombinant human parathyroid hormone on new bone formation during mandibular distraction osteogenesis and to investigate the dose-effect relationship associated with this phenomenon. Methods: A total of 4...περισσότερα »
Procedure-Based Residency Training
Comprehensive Observations of Resident Evolution: A Novel Method for Assessing Procedure-Based Residency Training: [image: image]Background: Assessment of surgical skills in the operating room remains a challenge. Increasing documentation requirements of the Accreditation Council for Graduate Medical Education are necessitating mechanisms to document trainee competence without hindering operative turnover. The authors created a comprehensive electronic resource to facilitate plastic surgery training program compliance with changes mandated by Next Accreditation System Milestones and... περισσότερα »
The Effect of Normovolemic and Hypervolemic Hemodilution on a Perforator Flap with Twisted Pedicle Model: Experimental Study in Rats
The Effect of Normovolemic and Hypervolemic Hemodilution on a Perforator Flap with Twisted Pedicle Model: Experimental Study in Rats: [image: image] Background: Several studies showed the detrimental effect of pedicle torsion on flap survival; however, the impact of hemodilution in this peculiar condition has never been investigated. This study evaluated the effect of acute normovolemic and hypervolemic hemodilution on flap survival in a perforator flap with twisted pedicle model. Methods: Sixty-three female Wistar rats were divided into three groups of 21 rats each: group 1, superf... περισσότερα »
Topical Administration of Oxygenated Hemoglobin Improved Wound Healing in an Ischemic Ear Model
Topical Administration of Oxygenated Hemoglobin Improved Wound Healing in an Ischemic Rabbit Ear Model: [image: image] Background: Localized oxygen deficiency plays a central role in the pathogenesis of chronic wounds; thus, rectifying localized ischemia with oxygen therapy has been postulated to be an integral aspect of the management of chronic wounds. The efficacy of a novel approach for oxygen therapy on chronic wound healing was evaluated. Methods: Oxygen was delivered to ischemic wounds by means of the topical application of oxygenated, chemically modified bovine hemoglobin (I...περισσότερα »
Thioredoxin Protects Skin Flaps from Ischemia-Reperfusion Injury
Thioredoxin Protects Skin Flaps from Ischemia-Reperfusion Injury: A Novel Prognostic and Therapeutic Target: Background: Ischemia-reperfusion injury is inevitable during free-tissue transfer, causing oxidative damage and extensive apoptosis. Thioredoxin is an endogenous protein with antioxidant and antiapoptotic activity in a variety of tissues. This study aims to investigate the protective effects of human thioredoxin-1 on ischemia-reperfusion flaps, and its clinical application value. Methods: Sixteen clinical specimens of ischemia-reperfusion flaps were collected and assessed for ... περισσότερα »
Transplantation of an LGR6+ Epithelial Stem Cell–Enriched Scaffold for Repair of Full-Thickness Soft-Tissue Defects: The In Vitro Development of Polarized Hair-Bearing Skin
Transplantation of an LGR6+ Epithelial Stem Cell–Enriched Scaffold for Repair of Full-Thickness Soft-Tissue Defects: The In Vitro Development of Polarized Hair-Bearing Skin: [image: image] Background: Recent literature has shown that full-thickness wounds, devoid of the stem cell niche, can subsequently be reconstructed with functional skin elements following migration of the LGR6+ epithelial stem cell into the wound bed. In this study, the authors use a variety of LGR6+ epithelial stem cell–seeded scaffolds to determine therapeutic utility and regenerative potential in the immedia... περισσότερα »
The Importance of the Upper Lateral Cartilage in Rhinoplasty
The Importance of the Upper Lateral Cartilage in Rhinoplasty: [image: image]Summary: The upper lateral cartilages are instrumental in obtaining optimal outcomes in aesthetic and functional rhinoplasty. Knowledgeable manipulation of the upper lateral cartilages can take advantage of the crucial malleable parameters of projection, width, nasal dorsal shape, and tip rotation. A lucid understanding of the anatomical intricacies in this portion of the cartilaginous framework permits the surgeon to use their unique characteristics to consistently achieve the desired results.
Aspiration of Periprosthetic Seromas Using the Blunt SeromaCath
Aspiration of Periprosthetic Seromas Using the Blunt SeromaCath: [image: image]Summary: Postoperative swelling following prosthetic implant breast augmentation and reconstruction is not uncommon. Prompt diagnosis and targeted treatment are critical. Current treatment recommendations achieve a diagnosis using specialized equipment with needle-guided imaging and/or surgical modalities. These techniques are expensive and delay diagnosis and treatment. The authors use an in-office, nonimaging technique to drain periprosthetic fluid after unilateral breast swelling after breast reconstru...περισσότερα »
Bergamo 3D Rhinoplasty Software: Select, Store, and Share Surgical Maneuvers in a Three-Dimensional Nasal Model
Bergamo 3D Rhinoplasty Software: Select, Store, and Share Surgical Maneuvers in a Three-Dimensional Nasal Model: [image: image]Background: Rhinoplasty is considered the most challenging chapter of plastic surgery due to its variability and the continuing evolution of surgical maneuvers. Worksheets became essential to unequivocally record surgical steps and to demonstrate their reciprocal effects/interactions during the follow-up period. After 1989, no other software was created to upgrade the Gunter Rhinoplasty Diagrams, the forefather and benchmark of the rhinoplasty “virtual” work... περισσότερα »
HSMNR belongs to the most frequent types of hereditary neuropathy in the Czech Republic and is twice more frequent than HMSNL
Abstract Hereditary motor and sensory neuropathy type Russe (HMSNR), also called CMT4G is an autosomal recessive inherited peripheral neuropathy (IPN) caused by a founder mutation in the *HK1* gene. HMSNR affects only patients with Roma origin, similar to the better known HMSN type Lom clarified earlier. By testing IPN patients with Roma origin we realized that HMSNR affects surprisingly many patients in the Czech Republic. HMSNR is one of the most frequent types of IPN in this country and seems to be twice more frequent than HMSNL. Pronounced lower limb atrophies and severe deform... περισσότερα »
Next-generation sequencing confirms the implication of SLC24A1 in autosomal-recessive congenital stationary night blindness (CSNB)
Abstract Congenital stationary night blindness (CSNB) is a clinically and genetically heterogeneous retinal disorder which represents rod photoreceptor dysfunction or signal transmission defect from photoreceptors to adjacent bipolar cells. Patients displaying photoreceptor dysfunction show a Riggs-electroretinogram (ERG) while patients with a signal transmission defect show a Schubert-Bornschein-ERG. The latter group is subdivided into complete or incomplete (ic) CSNB. Only few CSNB cases with Riggs-ERG and only one family with a disease causing variant in *SLC24A1* have been rep... περισσότερα »
Modification of Belsey (Mark IV) fundoplication in the management of hiatal hernia and gastroesophageal reflux disease after sleeve gastrectomy: a case report.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag]Related Articles *Modification of Belsey (Mark IV) fundoplication in the management of hiatal hernia and gastroesophageal reflux disease after sleeve gastrectomy: a case report.* Surg Obes Relat Dis. 2015 Mar-Apr;11(2):e19-20 Authors: Liang WT, Wu JM, Wang ZG PMID: 25820076 [PubMed - indexed for MEDLINE] from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1P1t3KG via IFTTT
Gastro-oesophageal reflux in young babies: who should be treated?
[image: http:--highwire.stanford.edu-icons-exter]Related Articles *Gastro-oesophageal reflux in young babies: who should be treated?* Arch Dis Child. 2015 Oct;100(10):989-93 Authors: Puntis JW Abstract Recent guidelines focus on a non-interventionist approach to management of gastro-oesophageal reflux in infancy and emphasise the importance of explanation, reassurance and simple measures such as attention to feeding. Relying on clinical history alone leads to over diagnosis of disease, and widely used medications are often ineffective for symptom relief and carry significant risk o...περισσότερα »
Dysphagia after radiotherapy: state of the art and prevention.
[image: http:--linkinghub.elsevier.com-ihub-imag]Related Articles *Dysphagia after radiotherapy: state of the art and prevention.* Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):25-9 Authors: Servagi-Vernat S, Ali D, Roubieu C, Durdux C, Laccourreye O, Giraud P Abstract Adjuvant radiotherapy after surgery or exclusive radiotherapy, with or without concurrent chemotherapy is a valuable treatment option in the great majority of patients with head and neck cancer. Recent technical progress in radiotherapy has resulted in a decreased incidence of xerostomia. Another common tox...περισσότερα »
Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy
Abstract We examined the effects of exercise on diaphragm degeneration and cardiomyopathy in dystrophin-deficient *mdx* mice. *Mdx* mice (11 months of age) were exercised (swimming) for 2 months to worsen diaphragm degeneration. Control *mdx* mice were kept sedentary. Morphological evaluation demonstrated increased fibrosis in the diaphragm of exercised *mdx* mice (33.3 ± 6.0% area of fibrosis) compared with control *mdx* mice (20.9 ± 1.7% area of fibrosis). Increased (26%) activity of MMP-2, a marker of fibrosis, was detected in the diaphragms from exercised *mdx* mice. Morphologi...περισσότερα »
Congenital Panfollicular Nevus in a 6-Month-Old Girl
Abstract A 6-month-old girl presented with an irregular nodule on the right lateral neck. The lesion, which superficially resembled a lymphangioma or mastocytoma, had been present since birth but had recently been growing. The patient was referred for surgical resection. Microscopic findings were compatible with a recently described rare hamartoma termed “panfollicular nevus,” which is a well-circumscribed lesion containing aberrantly differentiated, clustered hair follicles in high density. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1ns387H via IFTTT
Erythema Ab Igne in Three Girls with Anorexia Nervosa
Abstract We present three girls with the eating disorder anorexia nervosa (AN) presenting with erythema ab igne (EAI), a benign, reticular, erythematous dermatosis caused by repeated prolonged skin exposure to mild heat. AN has been associated with abnormal peripheral vascular response to cold, vasoconstriction of the limbs, low hand blood flow, exaggerated response to cold stimuli, subnormal core temperature, and a general feeling of cold that may encourage prolonged heat exposure and induce EAI. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1KeNeYH via IFTTT
Recurrent Coxsackievirus Infection in a Patient with Lamellar Ichthyosis
Abstract We describe a case of coxsackievirus (CV) A6 infection in a patient with lamellar ichthyosis followed by subsequent CV A8 infection within the same year. Atypical cutaneous features characterized the infection. This observation, combined with the rapidity with which reinfection occurred, suggests that the natural history of CV infection may be altered in patients with underlying ichthyoses. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1KeNbMy via IFTTT
“EB, or Not EB?” Neonatal Desquamative Impetigo in a Degloving Pattern
Abstract We present the case of a 7-day-old boy with significant, rapidly spreading blistering and desquamation in a “degloving” pattern on the hands that mimicked epidermolysis bullosa but was ultimately diagnosed as bullous impetigo caused by a clinically aggressive strain of *Staphylococcus aureus*. Bullous impetigo is a desquamating condition caused by local release of *S. aureus* exfoliative toxin A and is more commonly seen in children. This case highlights the fragility of newborn skin and reviews the major diagnoses that should be considered in an infant with significant bl... περισσότερα »
Subcutaneous Fat Necrosis of the Neonate with Subsequent Delayed-Onset Skin Eruption
Abstract Subcutaneous fat necrosis (SCFN) of the neonate is a rare panniculitis of early life that occurs in association with gestational diabetes and preeclampsia, as well as perinatal asphyxia, hypothermia, and trauma. A characteristic feature of this condition is its self-limiting and monophasic nature. We report a highly unusual case of delayed SCFN in a male neonate involving an anatomically discrete eruption, reminiscent of erythema nodosum, occurring many weeks after his original eruption had resolved. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Tr7jNw... περισσότερα »
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer
Background: To evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. Methods: Eighteen cases of soft tissue defect repair performed between January 2011 and December 2013 using a modified LAFF after resection of oral cancer were reviewed. The design and harvest of the LAFF, the reconstruction procedure, and postoperative morbidity were reviewed and evaluated over a follow-up period of at least 12 months. Results: The overall flap survival was 94.4 % (17/18 patients). A broad scar at the don... περισσότερα »
Evaluation of the changes of P1NP and CTX in synovial fluid and blood serum of dogs with experimental osteoarthritis
Abstract Osteoarthritis is a degenerative and reparative process occurring in synovial joints. In the present study, collagen type I C-telopeptide (CTX) and procollagen type I N-terminal propeptide (P1NP) were measured in blood serum and synovial fluid of four cross-breed dogs with experimental CCL rupture. These biomarkers were selected as bone turnover biomarkers. The markers were measured on days 0, 14, 28, 90, and 180 post surgery. Statistical analysis showed significant increase in P1NP in both serum and synovial fluid. The CTX showed a significant increase in serum and a non ... περισσότερα »
Body Dysmorphic Disorder in Patients Seeking Abdominoplasty, Rhinoplasty, and Rhytidectomy
Body Dysmorphic Disorder in Patients Seeking Abdominoplasty, Rhinoplasty, and Rhytidectomy: [image: image]Background: Body dysmorphic disorder may negatively affect self-perception of body shape and lead patients to seek cosmetic surgery. This study estimates the level of body dissatisfaction and prevalence of body dysmorphic disorder symptoms in candidates for three plastic surgical procedures. Methods: Three hundred patients of both sexes divided into three groups (abdominoplasty, n = 90; rhinoplasty, n =151; and rhytidectomy, n =59) were classified as having (n =51, n =79, and n =... περισσότερα »
Facial Fractures
Facial Fractures: [image: image]Learning Objectives: After reading this article, the participant should be able to: 1. Demonstrate an understanding of some of the changes in aspects of facial fracture management. 2. Assess a patient presenting with facial fractures. 3. Understand indications and timing of surgery. 4. Recognize exposures of the craniomaxillofacial skeleton. 5. Identify methods for repair of typical facial fracture patterns. 6. Discuss the common complications seen with facial fractures. Summary: Restoration of the facial skeleton and associated soft tissues after trau... περισσότερα »
Does the Eyebrow Sag with Aging?
Does the Eyebrow Sag with Aging? An Anthopometric Study of 95 Caucasians from 20 to 79 Years of Age: [image: image]Background: It is commonly assumed that a progressive sagging of the eyebrow occurs with the facial aging process. Only a few studies have analyzed this modification, and the findings are disparate and inconclusive. This study, based on reproducible and validated data, aimed to quantify the modifications of eyebrow position that may occur with aging. Also analyzed were the effects of these eyebrow position changes on the upper eyelid and on frontal muscle activity. Metho...περισσότερα »
Maximizing Symmetry in Upper Blepharoplasty: The Role of Microptosis Surgery
Maximizing Symmetry in Upper Blepharoplasty: The Role of Microptosis Surgery: [image: image]Background: Traditional descriptions of blepharoplasty and ptosis surgery focus on the incision and eyelid crease. However, it may be more useful to consider the tarsal platform show as the important construct in analyzing and planning aesthetic eyelid surgery. Methods: In order to measure and characterize the key contours of the eyelid, the authors find it helpful to consider the brow fat span, tarsal platform show, and margin reflex distance. Results: Subtle eyelid ptosis can result in asymme... περισσότερα »
Full Facial Feminization Surgery
Full Facial Feminization Surgery: Patient Satisfaction Assessment Based on 180 Procedures Involving 33 Consecutive Patients: Background: Gender dysphoria refers to the discomfort and distress that arise from a discrepancy between a person’s gender identity and sex assigned at birth. The treatment plan for gender dysphoria varies and can include psychotherapy, hormone treatment, and gender reassignment surgery, which is, in part, an irreversible change of sexual identity. Procedures for transformation to the female sex include facial feminization surgery, vaginoplasty, clitoroplasty,...περισσότερα »
IJMS, Vol. 17, Pages 184: Enhancement of Alkaline Protease Activity and Stability via Covalent Immobilization onto Hollow Core-Mesoporous Shell Silica Nanospheres
The stability and reusability of soluble enzymes are of major concerns, which limit their industrial applications. Herein, alkaline protease from Bacillus sp. NPST-AK15 was immobilized onto hollow core-mesoporous shell silica (HCMSS) nanospheres. Subsequently, the properties of immobilized proteases were evaluated. Non-, ethane- and amino-functionalized HCMSS nanospheres were synthesized and characterized. NPST-AK15 was immobilized onto the synthesized nano-supports by physical and covalent immobilization approaches. However, protease immobilization by covalent attachment onto the... περισσότερα »
Low-grade adenosquamous carcinoma of the breast: A diagnostic and clinical challenge.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Low-grade adenosquamous carcinoma of the breast: A diagnostic and clinical challenge.* Int J Surg. 2015 Jul;19:22-6 Authors: Tan QT, Chuwa EW, Chew SH, Lim-Tan SK, Lim SH Abstract Adenosquamous carcinoma of the breast (ASBC) is a rare variant of metaplastic breast cancer with both glandular as well as squamous differentiation. Their lack of distinct imaging characteristics, sometimes subtle histological characteristics and overlapping features with other benign lesions pose a diagnostic challenge. Unlike other fo...περισσότερα »
IJMS, Vol. 17, Pages 186: Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Due to drug-induced potential congestive heart failure and irreversible dilated cardiomyopathies, preclinical evaluation of cardiac dysfunction is important to assess the safety of traditional or novel treatments. The embryos of Nelumbo nucifera Gaertner seeds are a homology of traditional Chinese medicine and food. In this study, we applied the real time cellular analysis (RTCA) Cardio system, which can real-time monitor the contractility of cardiomyocytes (CMs), to evaluate drug safety in rat neonatal CMs and human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs).... περισσότερα »
IJMS, Vol. 17, Pages 181: Identification of Powdery Mildew Responsive Genes in Hevea brasiliensis through mRNA Differential Display
Powdery mildew is an important disease of rubber trees caused by Oidium heveae B. A. Steinmann. As far as we know, none of the resistance genes related to powdery mildew have been isolated from the rubber tree. There is little information available at the molecular level regarding how a rubber tree develops defense mechanisms against this pathogen. We have studied rubber tree mRNA transcripts from the resistant RRIC52 cultivar by differential display analysis. Leaves inoculated with the spores of O. heveae were collected from 0 to 120 hpi in order to identify pathogen-regulated ge... περισσότερα »
IJMS, Vol. 17, Pages 183: Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice
Senescence accelerated mice (SAM) are a group of mice that show aging-related diseases, and SAM prone 10 (SAMP10) show spontaneous brain atrophy and defects in learning and memory. Our previous report showed that the thymus and the percentage of T lymphocytes are abnormal in the SAMP10, but it was unclear whether the bone marrow-derived mesenchymal stroma cells (BMMSCs) were abnormal, and whether they played an important role in regenerative medicine. We thus compared BMMSCs from SAMP10 and their control, SAM-resistant (SAMR1), in terms of cell cycle, oxidative stress, and the exp... περισσότερα »
Bacteremia secondary to Alloscardovia omnicolens urinary tract infection
Publication date: Available online 28 January 2016 *Source:*Journal of Infection and Chemotherapy Author(s): Yoshihiko Ogawa, Akira Koizumi, Kei Kasahara, Sang-Tae Lee, Yuki Yamada, Ryuichi Nakano, Hisakazu Yano, Keiichi Mikasa A 70-year-old woman was admitted to our hospital with malaise, bilateral leg edema, and oliguria. She had a history of advanced uterine cancer. Bilateral double-J catheters were inserted because growth of intra-abdominal metastases led to bilateral ureteral stricture and hydronephrosis. Two days later, she suddenly developed high fever. Thin gram-positive bac...περισσότερα »
Distribution of virulence associated traits among urine Escherichia coli isolates from patients in onco-hematology
Publication date: Available online 28 January 2016 *Source:*Journal of Infection and Chemotherapy Author(s): Mariem Safi, Wafa Achour, Rekaya Baaboura, Rym El Fatmi, Tarek Ben othmen, Assia Ben Hassen Escherchia coli is the most common etiological agent of urinary tract infections. In this study we had two goals: First of all, to find out if urine stains isolated from our patients – having the particularity of being immunocompromised – would have a virulence genes distribution different from the one observed in strains isolated from ordinary patients. Second, we wanted to identify a... περισσότερα »
Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review.* Int J Surg. 2015 Jul;19:1-5 Authors: Musella A, De Felice F, Kyriacou AK, Barletta F, Di Matteo FM, Marchetti C, Izzo L, Monti M, Benedetti Panici P, Redler A, D'Andrea V Abstract BACKGROUND: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumor. Gynecological PEComas account for just over one-fourth of the overall PEComa cases reported in the literature. Surgery is the most recommended primary treatment whi...περισσότερα »
[Merkel cell carcinoma of the ear lobe complicated with nephrosis syndrome and malignant lymphoma: a case report].
*[Merkel cell carcinoma of the ear lobe complicated with nephrosis syndrome and malignant lymphoma: a case report].* Nihon Jinzo Gakkai Shi. 2015;57(8):1369-75 Authors: Okuno A, Arao M, Aoki K, Yonemoto S, Hayashi D, Fujii N, Oka K Abstract Here we report a rare case of Merkel cell carcinoma complicated with nephrosis and malignant lymphoma. A 79-year-old male, who had undergone rectectomy due to colorectal cancer about 10 years previously, was diagnosed as Merkel cell carcinoma of the left ear lobe with lymph node metastases. Tumor resection and lymph node dissection were perfor...περισσότερα »
Medoidshift clustering applied to genomic bulk tumor data.
*Medoidshift clustering applied to genomic bulk tumor data.* BMC Genomics. 2016;17 Suppl 1:6 Authors: Roman T, Xie L, Schwartz R Abstract Despite the enormous medical impact of cancers and intensive study of their biology, detailed characterization of tumor growth and development remains elusive. This difficulty occurs in large part because of enormous heterogeneity in the molecular mechanisms of cancer progression, both tumor-to-tumor and cell-to-cell in single tumors. Advances in genomic technologies, especially at the single-cell level, are improving the situation, but these ... περισσότερα »
Characterization of familial breast cancer in Saudi Arabia.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Characterization of familial breast cancer in Saudi Arabia.* BMC Genomics. 2015;16 Suppl 1:S3 Authors: Merdad A, Gari MA, Hussein S, Al-Khayat S, Tashkandi H, Al-Maghrabi J, Al-Thubaiti F, Hussein IR, Koumosani T, Shaer N, Chaudhary AG, Abuzenadah AM, Al-Qahtani MH, Dallol A Abstract BACKGROUND: The contribution of genetic factors to the development of breast cancer in the admixed and consanguineous population of the western region of Saudi Arabia is thought to be significant as the dise...περισσότερα »
Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series.* BMC Cancer. 2015;15:154 Authors: Yoo KH, Kim HS, Lee SJ, Park SH, Kim SJ, Kim SH, La Choi Y, Shin KH, Cho YJ, Lee J, Rha SY Abstract BACKGROUND: We retrospectively reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase angiogenesis inhibitor, in patients with advanced soft tissue sarcoma, a rare and heterogeneous tumor grou... περισσότερα »
Superficial acral fibromyxoma.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Superficial acral fibromyxoma.* Int J Dermatol. 2015;54(5):499-508 Authors: Sawaya JL, Khachemoune A Abstract Superficial acral fibromyxoma (SAF), also known as digital fibromyxoma, is a rare soft tissue tumor with a predilection for acral surfaces. Superficial acral fibromyxoma classically presents as a pink to flesh-colored nodule located on the subungual or periungual region of the hands or feet. It is typically slow-growing and asymptomatic, which, coupled with its nonspecific clinical appearance, presents a ...περισσότερα »
Efficacy and outcome of allogeneic transplantation in IgD and nonsecretory myeloma. A report on behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Efficacy and outcome of allogeneic transplantation in IgD and nonsecretory myeloma. A report on behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.* Biol Blood Marrow Transplant. 2015 Jun;21(6):1054-8 Authors: Morris C, Iacobelli S, Gahrton G, van Biezen A, Drake M, Garderet L, Potter M, Schattenberg AV, Cornelissen JJ, Hamladji RM, Martelli M, Petersen E, Rovira M, Bandini G, Kroger N, de Witte T Abstract We have recently report... περισσότερα »
Radiation myelitis after hypofractionated radiotherapy with concomitant gefitinib.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Radiation myelitis after hypofractionated radiotherapy with concomitant gefitinib.* Radiat Oncol. 2015;10:29 Authors: Lewitzki V, Andratschke N, Kuhnt T, Hildebrandt G Abstract We describe the case of a 71-year-old Caucasian female with primary disseminated non-small cell cancer of the lung, presented for palliative radiotherapy of metastatic spread to the 9th and 11th thoracic vertebrae without intramedullary growth. Palliative radiotherapy with daily fractions of 3 Gy and a cumulative... περισσότερα »
Clinical features of vestibular schwannomas in patients who experience hearing improvement after surgery.
[image: http:--production.springer.de-OnlineReso] Related Articles *Clinical features of vestibular schwannomas in patients who experience hearing improvement after surgery.* Neurosurg Rev. 2015 Apr;38(2):331-41; discussion 341 Authors: Kohno M, Sora S, Sato H, Shinogami M, Yoneyama H Abstract Postoperative improvements in hearing in patients with vestibular schwannoma are extremely rare. We reviewed nine cases retrospectively to investigate the clinical features of these cases. Hearing improvement was defined as an improvement in hearing class according to American Academy of Ot... περισσότερα »
Giant pedunculated pilomatrix carcinoma on the upper limb: A rare clinical appearance.
[image: http:--http://ift.tt/1Ms17yj] Related Articles *Giant pedunculated pilomatrix carcinoma on the upper limb: A rare clinical appearance.* Eur J Dermatol. 2015 Jan-Feb;25(1):91-2 Authors: Sato S, Nakamura Y, Shimizu M, Yamada K, Teramoto Y, Yamazaki N, Yamamoto A PMID: 25464929 [PubMed - indexed for MEDLINE] from #PubMed 3 via ola Kala on Inoreader http://ift.tt/1m08KoH via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1JLbcuE via IFTTT
Bacteremia secondary to Alloscardovia omnicolens urinary tract infection
Publication date: Available online 28 January 2016 *Source:*Journal of Infection and Chemotherapy Author(s): Yoshihiko Ogawa, Akira Koizumi, Kei Kasahara, Sang-Tae Lee, Yuki Yamada, Ryuichi Nakano, Hisakazu Yano, Keiichi Mikasa A 70-year-old woman was admitted to our hospital with malaise, bilateral leg edema, and oliguria. She had a history of advanced uterine cancer. Bilateral double-J catheters were inserted because growth of intra-abdominal metastases led to bilateral ureteral stricture and hydronephrosis. Two days later, she suddenly developed high fever. Thin gram-positive bac...περισσότερα »
Immediate disappearance of hemifacial spasm after partial removal of ponto-medullary junction anaplastic astrocytoma: case report.
[image: http:--production.springer.de-OnlineReso] Related Articles *Immediate disappearance of hemifacial spasm after partial removal of ponto-medullary junction anaplastic astrocytoma: case report.* Neurosurg Rev. 2015 Apr;38(2):385-90; discussion 390 Authors: Castiglione M, Broggi M, Cordella R, Acerbi F, Ferroli P Abstract Hemifacial spasm (HFS) is generally caused by a neurovascular conflict (NC) at the root exit zone (REZ) of the facial nerve at the brainstem. Although a direct compression to the seventh cranial nerve (CN) by the anterior inferior cerebellar artery (AICA) is ... περισσότερα »
Primary and Secondary Rhinoplasty
Long-Term Results and Refinement of the Turkish Delight Technique for Primary and Secondary Rhinoplasty: 25 Years of Experience: Background: All grafts present the potential problem of late visibility, distortion, and (occasionally) absorption. To overcome these problems and obtain a smoother surface, in 1989, the author initiated the use of finely diced cartilage wrapped in Surgicel. It is well known that the resolution of edema at the end of 1 year postoperatively is approximately 90 to 95 percent. Complete resolution continues until the end of 4 years postoperatively. However, it ... περισσότερα »
A Real-Time Local Flaps Surgical Simulator Based on Advances in Computational Algorithms for Finite Element Models
A Real-Time Local Flaps Surgical Simulator Based on Advances in Computational Algorithms for Finite Element Models: [image: image] Background: This article presents a real-time surgical simulator for teaching three- dimensional local flap concepts. Mass-spring based simulators are interactive, but they compromise accuracy and realism. Accurate finite element approaches have traditionally been too slow to permit development of a real-time simulator. Methods: A new computational formulation of the finite element method has been applied to a simulated surgical environment. The surgical...περισσότερα »
Pattern of recurrence of non-syndromic keratocystic odontogenic tumours
Pattern of recurrence of non-syndromic keratocystic odontogenic tumours via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 29 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Trond I. Berge, Saeedhe B. Helland, Andreas Sælen, Maria Øren, Anne Christine Johannessen, Liv Skartveit, Bjarte Grung Objectives and designThis retrospective chart study evaluates time to recurrence of 92 histologically confirmed non-syndromic keratocystic odontogenic tumours (KOT) treated at our institutions between ...περισσότερα »
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer: Background: To evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. Methods: Eighteen cases of soft tissue defect repair performed between January 2011 and December 2013 using a modified LAFF after resection of oral cancer were reviewed. The design and harvest of the LAFF, the reconstruction procedure, and postoperative morbidity were reviewed and evaluated over a follow-up p... περισσότερα »
Salivary duct carcinoma
Salivary duct carcinoma: a Danish national study: Background To present the first national series of salivary duct carcinoma patients, including survival rates and an analysis of prognostic factors. Methods By merging three Danish nationwide registries that encompass an entire population, 34 patients diagnosed with salivary duct carcinoma from 1990 to 2005 were identified. Histological slides were reviewed, and data concerning demographics, tumour site, clinical stage, treatment profiles and follow-up were retrieved. Survival estimates and prognostic factors were evaluated by compar... περισσότερα »
Odontogenic myxoma
Odontogenic myxoma: a clinicopathological study in a South African population: Background Odontogenic myxoma is a benign, locally aggressive neoplasm of the jaws. Prevalence rates range between 0.5% and 17.7% of odontogenic tumours. There are few reports in the literature on this lesion in African populations, and therefore, this study aimed to report on odontogenic myxoma in a South African population over a 40-year period. Methods The clinical records and orthopantomograms of 29 histopathologically diagnosed odontogenic myxoma were retrospectively analysed. Details of age, gender... περισσότερα »
Detecting neuromagnetic synchrony in the presence of noise
[image: S01650270.gif] Publication date: 15 March 2016 *Source:*Journal of Neuroscience Methods, Volume 262 Author(s): Elvis Wianda, Bernhard Ross BackgroundSynchrony between neuroelectric oscillations in distant brain areas is currently used as an indicator of functional connectivity between the involved neural substrates. Coherence measures, which quantify synchrony, are affected by concurrent brain activities, commonly subsumed as noise.New methodUsing Monte-Carlo simulation, we analysed the properties of circular statistics and how those are affected by noise. We considered thre...περισσότερα »
The demodulated band transform
[image: S01650270.gif] Publication date: 1 March 2016 *Source:*Journal of Neuroscience Methods, Volume 261 Author(s): Christopher K. Kovach, Phillip E. Gander BackgroundWindowed Fourier decompositions (WFD) are widely used in measuring stationary and non-stationary spectral phenomena and in describing pairwise relationships among multiple signals. Although a variety of WFDs see frequent application in electrophysiological research, including the short-time Fourier transform, continuous wavelets, bandpass filtering and multitaper-based approaches, each carries certain drawbacks relat... περισσότερα »
Erratum: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
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Pair exposure with conspecific during fear conditioning induces the link between freezing and passive avoidance behaviors in rats
[image: alertIcon.gif] Publication date: Available online 28 January 2016 *Source:*Neuroscience Research Author(s): Hyunchan Lee, Jihyun Noh Social factor plays an important role in dealing with posttraumatic stress disorder related to excessive physiological fear response and insufficient fear memory extinction of the brain. However, although social circumstances are occurred not only during contextual retrieval but also during fear conditioning, most previous studies focused on the advantageous aspects of social buffering in fear retrieval period. To demonstrate the association be...περισσότερα »
Neural mechanism of the nucleus accumbens circuit in reward and aversive learning
[image: alertIcon.gif] Publication date: Available online 28 January 2016 *Source:*Neuroscience Research Author(s): Takatoshi Hikida, Makiko Morita, Tom Macpherson The basal ganglia are key neural substrates not only for motor function, but also cognitive functions including reward and aversive learning. Critical for these processes are the functional role played by two projection neurons within nucleus accumbens (NAc); the D1- and D2-expressing neurons. Recently, we have developed a novel reversible neurotransmission blocking technique that specifically blocks neurotransmission fro...περισσότερα »
Phenethyl isothiocyanate enhances TRAIL-induced apoptosis in oral cancer cells and xenografts
Phenethyl isothiocyanate enhances TRAIL-induced apoptosis in oral cancer cells and xenografts: Abstract ObjectivesTumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been regarded as a promising candidate for cancer therapy. However, most of oral cancer cell lines are resistant to the TRAIL-induced cytotoxicity. The aim of this study was to investigate the ability of phenethyl isothiocyanate (PEITC) to sensitize TRAIL-induced apoptosis in TRAIL-resistant oral cancer cells and xenografts. Materials and methodsTerminal deoxynucleotidyl transferase-mediated dUTP ni... περισσότερα »
Cancer Immunology, Immunotherapy, Vol. 65, Issue 2 - New Issue Alert
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 01/29/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Cancer Immunology, Immunotherapy*. Volume 65 Number 2 is now available online. In this issue Original Article Increasing radiation dose improves immunotherapy outcome and prolongation of tumor dormancy in a subgroup of mice treated for advanced intracerebral melanoma Henry M. Smilowitz, Peggy L. Micca, Daniel Sasso, Qian Wu, Nathanial Dyment, Crystal Xue ... περισσότερα »
Managing patients taking novel oral anticoagulants (NOAs)
Managing patients taking novel oral anticoagulants (NOAs) in dentistry: a discussion paper on clinical implications: Abstract BackgroundThe aim of this paper is to contribute to the discussion on how to approach patients taking new orally administered anticoagulants (NOAs) dabigatran etexilate (a direct thrombin inhibitor), rivaroxaban and apixaban (factor Xa inhibitors), before, during and after dental treatment in light of the more recent knowledges. DiscussionIn dentistry and oral surgery, the major concerns in treatment of patients taking direct thrombin inhibitors and fact... περισσότερα »
Open-bite treatment with vertical control and tongue reeducation
Open-bite treatment with vertical control and tongue reeducation via http://rss.sciencedirect.com/publication/science/08895406 Publication date: February 2016 *Source:*American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 2 Author(s): Justin Garrett, Eustaquio Araujo, Christopher Baker An open-bite malocclusion with a tongue-thrust habit is a challenging type of malocclusion to correct. A 12-year-old girl came for orthodontic treatment with a severe anterior open bite, extruded posterior segments, a tongue-thrust habit, and lip incompetency. Her parents refused... περισσότερα »
Skeletal Class III malocclusion
Progressive changes in patients with skeletal Class III malocclusion treated by 2-jaw surgery with minimal and conventional presurgical orthodontics: A comparative study via http://rss.sciencedirect.com/publication/science/08895406 Publication date: February 2016 *Source:*American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 2 Author(s): Yang Zhou, Zili Li, Xiaoxia Wang, Bingshuang Zou, Yanheng Zhou IntroductionIn this study, we aimed to compare treatment efficacy and postsurgical stability between minimal presurgical orthodontics and conventional presurgical ...περισσότερα »
Facial hard and soft tissue asymmetry
Evaluation of facial hard and soft tissue asymmetry using cone-beam computed tomography via http://rss.sciencedirect.com/publication/science/08895406 Publication date: February 2016 *Source:*American Journal of Orthodontics and Dentofacial Orthopedics, Volume 149, Issue 2 Author(s): Rahime Burcu Nur, Derya Germeç Çakan, Tülin Arun IntroductionThe purposes of this study were to (1) evaluate facial asymmetry 3 dimensionally using cone-beam computed tomography (CBCT) and (2) compare the right and left facial hard and soft tissues volumetrically and their interferences on each other.Method... περισσότερα »
Lymphatische Malformationen im Kopf-Hals-Bereich
Lymphatische Malformationen im Kopf-Hals-Bereich: ZusammenfassungLymphatische Malformationen sind angeborene Malformationen des Lymphgefäßsystems, die hauptsächlich im Kopf-Hals-Bereich lokalisiert sind und ein dem Körperwachstum proportionales Wachstum aufweisen. In Abhängigkeit von der Morphologie werden makrozystische, mikrozystische und gemischte lymphatische Malformationen unterschieden. Aufgrund ihres infiltrativen Wachstums sind insbesondere mikrozystische lymphatische Malformationen schwer zu therapieren. Therapieansätze umfassen die konventionell-chirurgische Resektion, La... περισσότερα »
Is rigid endoscopy necessary with childhood corrosive ingestion? a retrospective comparative analysis of 458 cases
Is rigid endoscopy necessary with childhood corrosive ingestion? a retrospective comparative analysis of 458 cases: Summary The aim of this study was to determine the necessity of endoscopy in cases in which a corrosive substance was ingested and to find a practical way to avoid unnecessary endoscopies for similar cases in the future. The clinical records of 458 hospitalized cases with clinical histories of corrosive substance ingestion between January 2007 and December 2013 were retrospectively reviewed. The demographics of the cases, the ingested substances, and the rigid endosco...περισσότερα »
Polymorphisms of the FOXF1 and MHC locus genes in individuals undergoing esophageal acid reflux assessments
Polymorphisms of the FOXF1 and MHC locus genes in individuals undergoing esophageal acid reflux assessments: Summary Gastroesophageal reflux disease (GERD) may lead to Barrett's esophagus (BE). Previously, a large genome-wide association study found two germline markers to be associated with BE, FOXF1 rs9936833 (C allele) and MHC rs9257809 (A allele). This study evaluated whether these two polymorphisms are associated with gastroesphageal acid reflux as measured by 24-hour pH testing. Patients with acid reflux symptoms referred for esophageal manometry and 24-hour pH monitoring at ... περισσότερα »
Most children with eosinophilic esophagitis have a favorable outcome as young adults
Most children with eosinophilic esophagitis have a favorable outcome as young adults: Summary The disease progression of eosinophilic esophagitis (EoE) from childhood into adulthood is unclear. To determine the clinical outcome of patients who were diagnosed with EoE as children, and who now are young adults. Children (<18 years old) diagnosed with EoE were enrolled in a prospective registry on demographics, presenting symptoms, and endoscopic/histologic findings. Subjects who now are adults (≥18 years old) were identified, and a structured telephone interview was conducted to obta... περισσότερα »
Esophageal ectopic sebaceous glands
Prevalence rate and clinical characteristics of esophageal ectopic sebaceous glands in asymptomatic health screen examinees: Summary Ectopic sebaceous glands in the esophagus have rarely been reported and, thus, represent an obscure medical condition. The aim of this study is to identify the prevalence rate and clinical characteristics of this lesion in an asymptomatic population. We prospectively enrolled health screen examinees who underwent esophagogastroduodenoscopy for gastric cancer screening. An esophageal biopsy was performed in the cases in which esophageal ectopic sebaceo... περισσότερα »
Helicobacter pylori and Antibiotic Resistance
Helicobacter pylori and Antibiotic Resistance, A Continuing and Intractable Problem: Abstract *Helicobacter pylori*, a human pathogen with a high global prevalence, is the causative pathogen for multiple gastrointestinal diseases, especially chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric malignancies. Antibiotic therapies remain the mainstay for *H. pylori* eradication; however, this strategy is hampered by the emergence and spread of *H. pylori* antibiotic resistance. Exploring the mechanistic basis of this resistance is becoming ... περισσότερα »
Infection Prevention in Transplantation
Infection Prevention in Transplantation: AbstractThe number of patients undergoing hematopoietic cell and solid organ transplantation are increasing every year, as are the number of centers both transplanting and caring for these patients. Improvements in transplant procedures, immunosuppressive regimens, and prevention of transplant-associated complications have led to marked improvements in survival in both populations. Infections remain one of the most important sources of excess morbidity and mortality in transplant, and therefore, infection prevention strategies are a critical...περισσότερα »
Bilateral femoral hypoplasia and facial dysmorphism : Femoral facial syndrome
Femoral facial syndrome associated with a de novo complex chromosome 2q37 rearrangement: The femoral facial syndrome (FFS) is a rare congenital anomaly syndrome characterized by bilateral femoral hypoplasia and facial dysmorphism. The etiology of FFS is currently unknown but maternal/gestational diabetes has been proposed as a strong risk factor for syndromic femoral hypoplasia. In affected children born to non-diabetic mothers, a genetic contribution to FFS is suspected; however, no chromosomal anomalies or gene mutations have been identified so far. Here, we report on a girl with...περισσότερα »
Feasibility of self-administered sleep assessment in older women in the Women’s Health Initiative (WHI)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose Laboratory-based polysomnography (PSG) is the gold standard assessment of sleep disordered breathing (SDB). In large cohort studies and clinical trials, however, these overnight procedures can be expensive and burdensome to participants, especially older adults. In preparation for a large observational study, we determined the feasibility of self-administering two devices mailed to participants’ homes […]
Unusual large functional adrenocortical carcinoma in a young woman
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description A 27-year-old woman presented with an abdominal lump and features of Cushing syndrome with virilisation, namely, weight gain, acne, hyperpigmentation, hirsutism, central obesity, rounded face, stretch marks, osteoporosis, dyslipidaemia, hypertension and amenorrhoea (figure 1). Serum testosterone and cortisol levels were elevated. Oestradiol and 24 h urinary metanephrine were within normal range. contrast-enhanced CT of […]
Ureteric lymphoma as a rare cause of right lower ureteric obstruction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Primary lymphoid neoplasms of the urinary tract are exceedingly rare, with only 21 cases being reported and comprising less than 5% of all primary extranodal lymphomas. We report a case of a 45-year-old man who presented with right flank pain and weight loss, and who was found to have a stricture in the right lower […]
Successful pregnancy with autoimmune cirrhosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pregnancy with liver cirrhosis is a rare and dangerous event that exposes mother and fetus to potentially lethal risks. During pregnancy, hepatic decompensation could suffice and the development of hepatic failure and encephalopathy could occur. The incidence of obstetric complications is also increased with a high rate of pre-eclampsia, postpartum bleeding, preterm delivery and stillbirth. […]
Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A 14-year-old girl who was known to have a seizure disorder and on lamotrigine treatment was admitted to the hospital, with a history of rash, fever and cough. Her condition deteriorated with clinical features suggestive of anticonvulsant hypersensitivity syndrome (ACHS) complicated with bronchiolitis obliterans organising pneumonia (BOOP). Her chest CT showed multifocal parenchymal opacities and […]
Rare gynaecological emergency: massive intraperitoneal haemorrhage from spontaneous rupture of a superficial vessel on a large leiomyoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Uterine leiomyomas rarely present as gynaecological emergencies. We report a case of a 29-year-old nulliparous woman, with a negative pregnancy test, who presented with collapse and an admission haemoglobin count of 68 g/L. Urgent CT of the abdomen revealed a 14x19x10 cm uterine fibroid and intraperitoneal free fluid. Emergency laparotomy confirmed massive intraperitoneal haemorrhage from […]
Kleptomania following hypoxic-ischaemic damage to bilateral caudate nuclei
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description We report a case of a 40-year-old woman, with no history of mental illness or substance abuse, who underwent cosmetic plastic surgery. In the immediate postoperative period, she presented somnolence, disorientation, apathy and memory deficits. Neurological investigation with brain MRI (figure 1) and cerebral perfusion scintigraphy (figure 2) was conducted. The former revealed bilateral […]
Lipoprotein lipase deficiency presenting with neonatal perianal abscesses
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Lipoprotein lipase (LPL), a member of the triglyceride lipase gene family, is synthesised by parenchymal cells of the heart, skeletal muscle and adipose tissues before being transported to luminal surfaces of vascular endothelial cells to exert its main physiological function to hydrolyse plasma lipoproteins. LPL deficiency is a rare autosomal recessive disorder, resulting in severe […]
Laryngopyocoele: an unusual cause of airway obstruction
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description An 88-year-old woman presented with a 2-day history of dysphagia, hoarseness and inspiratory stridor. Examination revealed well-defined soft lobulated masses anteriorly and to the right of her neck. Flexible-nasendoscopy demonstrated a large mass displacing the right false-cord and compressing the epiglottis. She had good air entry to all lung fields and laboratory testing revealed […]
Neuromyelitis optica spectrum disorder associated with osmotic demyelination syndrome
from Neurology via xlomafota13 on Inoreader http://ift.tt/1PEzt1F via IFTTT
Magnetic resonance parkinsonism index in progressive supranuclear palsy and vascular parkinsonism
Abstract To investigate accuracy of the magnetic resonance parkinsonism index (MRPI) in differentiating progressive supranuclear palsy (PSP) from vascular parkinsonism (VP). We retrospectively analyzed radiological data of 12 PSP patients and 17 VP patients group-matched by age and sex who performed a standardized brain magnetic resonance imaging (MRI). Analysis of selected structures morphometry was performed to all study subjects and the MRPI was calculated for each selected patient. MRI midbrain area as well as superior cerebellar peduncle width were significantly lower in PSP p... περισσότερα »
Unilateral hypoplasia with contralateral hypertrophy of anterior belly of digastric muscle: a case report
Abstract Anomalies of the anterior belly of the digastric muscle (DM) are uncommon. We present a case of hypoplasia of the anterior belly of the left DM with hypertrophy of the anterior belly of the contralateral DM. The importance of recognizing this finding is to differentiate hypoplasia of the anterior belly of the DM from denervation atrophy, and not to confuse contralateral hypertrophy with a submental mass or lymphadenopathy. In denervation atrophy of the anterior belly of the DM, associated atrophy of the ipsilateral mylohyoid muscle is present. Hypertrophy of the anterior b... περισσότερα »
Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy
Abstract We examined the effects of exercise on diaphragm degeneration and cardiomyopathy in dystrophin-deficient *mdx* mice. *Mdx* mice (11 months of age) were exercised (swimming) for 2 months to worsen diaphragm degeneration. Control *mdx* mice were kept sedentary. Morphological evaluation demonstrated increased fibrosis in the diaphragm of exercised *mdx* mice (33.3 ± 6.0% area of fibrosis) compared with control *mdx* mice (20.9 ± 1.7% area of fibrosis). Increased (26%) activity of MMP-2, a marker of fibrosis, was detected in the diaphragms from exercised *mdx* mice. Morpholog...περισσότερα »
Obese patients who fall have less injury severity but a longer hospital stay than normal-weight patients
World Journal of Emergency Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QwVJO3 via IFTTT
The surgical stabilization of multiple rib fractures using titanium elastic nail in blunt chest trauma with acute respiratory failure
Surgical Endoscopy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1nCxbdr via IFTTT
Population pharmacokinetic modeling of tapentadol extended release (ER) in healthy subjects and patients with moderate or severe chronic pain
Clinical Drug Investigation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QwVJxx via IFTTT
The Prevalence of alcohol and Psychotropic drugs in fatalities of road-traffic accidents in Jordan during 2008 – 2014
Journal of Forensic and Legal Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1nCxa9w via IFTTT
Surgical treatment of a case of adult epiglottic laryngomalacia.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Surgical treatment of a case of adult epiglottic laryngomalacia.* Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):45-7 Authors: Bartolomeo M, Bigi A, Pelliccia P, Makeieff M Abstract INTRODUCTION: Adult laryngomalacia is rare. It may be idiopathic or secondary to trauma or degenerative disease. CASE REPORT: A 25-year-old man presented with inspiratory dyspnea on effort of several months' evolution. Flexible endoscopy found epiglottic laryngomalacia, managed by CO2 laser V-shaped partial epiglottectomy. DISC... περισσότερα »
GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *GTV delineation in supraglottic laryngeal carcinoma: interobserver agreement of CT versus CT-MR delineation.* Radiat Oncol. 2015;10:26 Authors: Jager EA, Kasperts N, Caldas-Magalhaes J, Philippens ME, Pameijer FA, Terhaard CH, Raaijmakers CP Abstract BACKGROUND: GTV delineation is the first crucial step in radiotherapy and requires high accuracy, especially with the growing use of highly conformal and adaptive radiotherapy techniques. If GTV delineations of observers concord, they are c... περισσότερα »
A National Population Study of the Co-Occurrence of Multiple Long-Term Conditions in People With Multimorbidity, Denmark, 2013.
*A National Population Study of the Co-Occurrence of Multiple Long-Term Conditions in People With Multimorbidity, Denmark, 2013.* Prev Chronic Dis. 2016;13:E12 Authors: Friis K, Pedersen MH, Larsen FB, Lasgaard M Abstract The objective of this study was to describe the prevalence of pairwise combinations of 17 long-term conditions. Data were obtained from a national, representative population-based study including 162,283 Danish citizens aged 16 years or older. We calculated the prevalence of each long-term condition given the presence of another long-term condition. Compared wi...περισσότερα »
Rare gynaecological emergency: massive intraperitoneal haemorrhage from spontaneous rupture of a superficial vessel on a large leiomyoma
Uterine leiomyomas rarely present as gynaecological emergencies. We report a case of a 29-year-old nulliparous woman, with a negative pregnancy test, who presented with collapse and an admission haemoglobin count of 68 g/L. Urgent CT of the abdomen revealed a 14x19x10 cm uterine fibroid and intraperitoneal free fluid. Emergency laparotomy confirmed massive intraperitoneal haemorrhage from a large serosal vessel on top of a 19 cm subserosal fibroid. A myomectomy was performed, preserving this patient's fertility. Histopathology confirmed a benign leiomyoma with hydropic changes. ...περισσότερα »
Kleptomania following hypoxic-ischaemic damage to bilateral caudate nuclei
Description We report a case of a 40-year-old woman, with no history of mental illness or substance abuse, who underwent cosmetic plastic surgery. In the immediate postoperative period, she presented somnolence, disorientation, apathy and memory deficits. Neurological investigation with brain MRI (figure 1) and cerebral perfusion scintigraphy (figure 2) was conducted. The former revealed bilateral nucleocapsular hypoxic-ischaemic injury, while the latter demonstrated relative hypoperfusion in the frontal lobes (figure 2A), anterior portions of the cingulate gyri (figure 2B), basa... περισσότερα »
Lipoprotein lipase deficiency presenting with neonatal perianal abscesses
Lipoprotein lipase (LPL), a member of the triglyceride lipase gene family, is synthesised by parenchymal cells of the heart, skeletal muscle and adipose tissues before being transported to luminal surfaces of vascular endothelial cells to exert its main physiological function to hydrolyse plasma lipoproteins. LPL deficiency is a rare autosomal recessive disorder, resulting in severe hypertriglyceridaemia from birth. The effect of marked hypertriglyceridaemia on the immune function in children has not been described. We present a case of a neonate with LPL deficiency and grossly el... περισσότερα »
upper respiratory tract infection; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/01/29 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1nsdZhV via IFTTT
Expansion and homing of umbilical cord blood hematopoietic stem and progenitor cells for clinical transplantation.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Expansion and homing of umbilical cord blood hematopoietic stem and progenitor cells for clinical transplantation.* Biol Blood Marrow Transplant. 2015 Jun;21(6):1008-19 Authors: Bari S, Seah KK, Poon Z, Cheung AM, Fan X, Ong SY, Li S, Koh LP, Hwang WY Abstract The successful expansion of hematopoietic stem and progenitor cells (HSPCs) from umbilical cord blood (UCB) for transplantation could revolutionize clinical practice by improving transplantation-related outcomes and making available UCB units that have subo... περισσότερα »
Current state of the art, multimodality research and future visions for the treatment of patients with prostate cancer: consensus results from "Challenges and Chances in Prostate Cancer Research Meeting 2013".
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Current state of the art, multimodality research and future visions for the treatment of patients with prostate cancer: consensus results from "Challenges and Chances in Prostate Cancer Research Meeting 2013".* Radiat Oncol. 2014;9:224 Authors: Combs SE, Debus J, Feick G, Hadaschik B, Hohenfellner M, Schüle R, Zacharias JP, Schwardt M Abstract A brainstorming and consensus meeting organized by the German Cancer Aid focused on modern treatment of prostate cancer and promising innovative ... περισσότερα »
Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.
*Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.* PLoS One. 2016;11(1):e0147682 Authors: Kiessling MK, Curioni-Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, Oldrige DA, Maris JM, Rogler G Abstract High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of patients. However, few inhibitors for the potential treatment for NRAS mutant neuroblastoma have been invest...περισσότερα »
Medoidshift clustering applied to genomic bulk tumor data.
*Medoidshift clustering applied to genomic bulk tumor data.* BMC Genomics. 2016;17 Suppl 1:6 Authors: Roman T, Xie L, Schwartz R Abstract Despite the enormous medical impact of cancers and intensive study of their biology, detailed characterization of tumor growth and development remains elusive. This difficulty occurs in large part because of enormous heterogeneity in the molecular mechanisms of cancer progression, both tumor-to-tumor and cell-to-cell in single tumors. Advances in genomic technologies, especially at the single-cell level, are improving the situation, but these ... περισσότερα »
[Merkel cell carcinoma of the ear lobe complicated with nephrosis syndrome and malignant lymphoma: a case report].
*[Merkel cell carcinoma of the ear lobe complicated with nephrosis syndrome and malignant lymphoma: a case report].* Nihon Jinzo Gakkai Shi. 2015;57(8):1369-75 Authors: Okuno A, Arao M, Aoki K, Yonemoto S, Hayashi D, Fujii N, Oka K Abstract Here we report a rare case of Merkel cell carcinoma complicated with nephrosis and malignant lymphoma. A 79-year-old male, who had undergone rectectomy due to colorectal cancer about 10 years previously, was diagnosed as Merkel cell carcinoma of the left ear lobe with lymph node metastases. Tumor resection and lymph node dissection were perfor...περισσότερα »
Low-grade adenosquamous carcinoma of the breast: A diagnostic and clinical challenge.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Low-grade adenosquamous carcinoma of the breast: A diagnostic and clinical challenge.* Int J Surg. 2015 Jul;19:22-6 Authors: Tan QT, Chuwa EW, Chew SH, Lim-Tan SK, Lim SH Abstract Adenosquamous carcinoma of the breast (ASBC) is a rare variant of metaplastic breast cancer with both glandular as well as squamous differentiation. Their lack of distinct imaging characteristics, sometimes subtle histological characteristics and overlapping features with other benign lesions pose a diagnostic challenge. Unlike other fo...περισσότερα »
Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Perivascular epithelioid cell neoplasm (PEComa) of the uterus: A systematic review.* Int J Surg. 2015 Jul;19:1-5 Authors: Musella A, De Felice F, Kyriacou AK, Barletta F, Di Matteo FM, Marchetti C, Izzo L, Monti M, Benedetti Panici P, Redler A, D'Andrea V Abstract BACKGROUND: Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal tumor. Gynecological PEComas account for just over one-fourth of the overall PEComa cases reported in the literature. Surgery is the most recommended primary treatment whi...περισσότερα »
Characterization of familial breast cancer in Saudi Arabia.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Characterization of familial breast cancer in Saudi Arabia.* BMC Genomics. 2015;16 Suppl 1:S3 Authors: Merdad A, Gari MA, Hussein S, Al-Khayat S, Tashkandi H, Al-Maghrabi J, Al-Thubaiti F, Hussein IR, Koumosani T, Shaer N, Chaudhary AG, Abuzenadah AM, Al-Qahtani MH, Dallol A Abstract BACKGROUND: The contribution of genetic factors to the development of breast cancer in the admixed and consanguineous population of the western region of Saudi Arabia is thought to be significant as the dise...περισσότερα »
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