Chronic inflammatory skin conditions
Education to improve quality of life of people with chronic inflammatory skin conditions: a systematic review of the evidence: Summary Patient and carer education has been proposed as a way of improving health-related quality of life (HRQoL) among people with chronic inflammatory skin conditions. This systematic review aimed to assess the effects of education which specifically addresses HRQoL among people with chronic inflammatory skin conditions. We searched 12 literature databases and other sources (to July 2014). Seven randomised controlled trials (RCTs) met the review inclusio...περισσότερα »
Segmental neurofibromatosis (SNF) is a rare variant of neurofibromatosis 1 (NF1)
Evaluation of learning disabilities in segmental neurofibromatosis: Abstract Segmental neurofibromatosis (SNF) is a rare variant of neurofibromatosis 1 (NF1) in which patients have typical disease features limited to one or more body segments. However, a consensual definition is lacking. In 2001, Ruggieri and Huson proposed the following classification for SNF:1 pigmentary changes only; neurofibromas only; pigmentary changes plus neurofibromas; solitary plexiform neurofibromas. This article is protected by copyright. All rights reserved.
Decreased expression of activin A receptor 1C may result in Ca2+-induced aberrant skin hypersensitivity
Decreased expression of activin A receptor 1C may result in Ca2+-induced aberrant skin hypersensitivity: Sensitive skin is a hyperactive skin condition characterized by exaggerated sensory symptoms in response to internal stimulants and external irritants such as cosmetics. Recently, we showed that sensitive skin is associated with dysfunction of muscle contraction and metabolic homeostasis including adiponectin deficiency. Our previous microarray dataset (GEO series accession number GSE48506) revealed that the expression of various signaling pathway-regulated genes including activ... περισσότερα »
Plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases
Update on the role of plasmacytoid dendritic cells in inflammatory/autoimmune skin diseases: Abstract Plasmacytoid dendritic cells (pDCs) represent a specialized dendritic cell population that exhibit plasma cell morphology, express CD4, CD123, blood-derived dendritic cell antigen-2 (BDCA-2) and Toll-like receptor (TLR)7 and TLR9 within endosomal compartments. When activated, pDCs are capable of producing large quantities of type I IFNs (mainly IFN-*α*/*β*) which provide anti-viral resistance and link the innate and adaptive immunity. While generally lacking from normal skin, pDCs ...περισσότερα »
Glycyrrhizic acid prevents Ultraviolet- B induced photodamage
Glycyrrhizic acid prevents Ultraviolet- B induced photodamage: A role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway: Abstract Glycyrrhizic acid (GA), a natural triterpene has received attention as an agent that has protective effects against chronic diseases including ultraviolet UV-B -induced skin photodamage. However, the mechanism of its protective effect remains elusive. Here we used an immortalized human keratinocyte cell line (HaCaT) and a small animal model (BALB/c mice), to investigate the protective effects of GA against ... περισσότερα »
Meningeosis lymphomatosa
Meningeosis lymphomatosa: Zusammenfassung HintergrundDie Meningeosis lymphomatosa ist ein meist fatales Ereignis. Eine gezielte Diagnostik ist erforderlich, um eine optimale Therapie einleiten und die Prognose der Patienten verbessern zu können. Zu unterscheiden sind die sekundäre ZNS-Beteiligung (ZNS: Zentralnervensystem) im Krankheitsverlauf sowie das primär simultane Auftreten eines zentralen und peripheren Lymphoms bei der Erstdiagnose. Ziel der ArbeitDie Inzidenz, die diagnostischen und therapeutischen Möglichkeiten bei Meningeosis lymphomatosa sollen dargestellt werden. ...περισσότερα »
Anti-Cortisol Antibody in Atopic Dermatitis with Topical Steroid Addiction
Histological and Immunohistological Findings Using Anti-Cortisol Antibody in Atopic Dermatitis with Topical Steroid Addiction: Abstract IntroductionThough topical steroid addiction (TSA) in patients with atopic dermatitis (AD) has been recently discussed as a clinical problem, there are very few studies about its mechanism. The purpose of this study was to elucidate histological and immunohistological characteristics of TSA using anti-cortisol antibody. MethodsSkin biopsy specimen from eight patients with AD was stained by anti-cortisol antibody (Biorbyt, orb79379). Subjects co... περισσότερα »
Benzoate Allergy in Children—From Foods to Personal Hygiene Products
Benzoate Allergy in Children—From Foods to Personal Hygiene Products: Abstract Benzoate allergy may be an overlooked allergen in children and one that may be of increasing importance with its increasing role as a preservative in pediatric personal hygiene formulations. The cases herein report an association with cola and benzoate allergy and discusses the implications of replacement of formaldehyde by benzoates in personal hygiene products.
Topical use of timolol for infantile hemangiomas
Topical Timolol: Evidence for Efficacy and Degree of Systemic Absorption: Abstract Background Topical use of timolol for infantile hemangiomas has recently emerged with promising results. It is unknown whether topical β-blockers act locally or if their effect is partly due to systemic absorption. This study investigates whether topically applied timolol is absorbed and reports on the efficacy of this treatment. Methods We treated 40 infants with small proliferating hemangiomas with topical timolol gel 0.5% twice daily and assessed urinary excretion and serum levels in a proportion o... περισσότερα »
Erythematous Papules and Plaques on the Cheeks
Erythematous Papules and Plaques on the Cheeks: A man presented with a 3-year history of recurring erythematous papules on the bilateral cheeks, despite topical steroid therapy, without any additional symptoms. Polyclonal hypergammaglobulinemia was found on serum protein electrophoresis. What is your diagnosis? [image: First page PDF preview]
Photodynamic Therapy in Daylight
Photodynamic Therapy in Daylight: In conventional photodynamic therapy (PDT) for the treatment of actinic keratoses (AK), 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) is applied to the skin after gentle curettage and stays there for a defined period of time (often 3 hours) to ensure accumulation of protoporphyrin IX (PpIX). During this time the treated area must be covered against light by a bandage. After the PpIX accumulation, certified lamps are used for a short illumination of the photosensitized skin to activate PpIX. In this process PpIX loses its activity and f... περισσότερα »
Mild extrinsic and intrinsic atopic dermatitis
Distinct molecular signatures of mild extrinsic and intrinsic atopic dermatitis: Abstract Atopic dermatitis (AD) is a common inflammatory skin disease with underlying defects in epidermal function and immune responses. In this study, we used microarray analysis to investigate differences in gene expression in lesional skin from patients with mild extrinsic or intrinsic AD compared to skin from healthy controls and from lesional psoriasis skin. The primary aim was to identify differentially expressed genes involved in skin barrier formation and inflammation, and to compare our resul... περισσότερα »
Infrared A Radiation Promotes Survival of Human Melanocytes Carrying Ultraviolet Radiation-Induced DNA Damage
Infrared A Radiation Promotes Survival of Human Melanocytes Carrying Ultraviolet Radiation-Induced DNA Damage: Abstract The link between solar radiation and melanoma is still elusive. Although infrared radiation (IR) accounts for over 50% of terrestrial solar energy, its influence on human skin is not well explored. There is increasing evidence that IR influences the expression patterns of several molecules independently of heat. A previous *in vivo* study revealed that pre-treatment with IR might promote the development of UVR-induced non-epithelial skin cancer and possibly of mel... περισσότερα »
Atopalm ® Multi-Lamellar Emulsion Cream and Physiogel ® Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin
Comparison of the Efficacy of Atopalm ® Multi-Lamellar Emulsion Cream and Physiogel ® Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin: Abstract IntroductionThe management of sensitive skin, which affects over 60% of the general population, has been a long-standing challenge for both patients and clinicians. Because defective epidermal permeability barrier is one of the clinical features of sensitive skin, barrier-enhancing products could be an optimal regimen for sensitive skin. In the present study, we evaluated the efficacy and safety of two barrier... περισσότερα »
Dermoscopy and Reflectance Confocal Microscopy for Monitoring the Treatment of Actinic Keratosis with Ingenol Mebutate Gel: Report of Two Cases
Dermoscopy and Reflectance Confocal Microscopy for Monitoring the Treatment of Actinic Keratosis with Ingenol Mebutate Gel: Report of Two Cases: Abstract IntroductionA relatively novel application for dermoscopy and reflectance confocal microscopy (RCM) is their use in the monitoring of topical treatment response for non-melanoma skin cancer. Actinic keratosis (AK) is the early phase of a multistep biologic continuum leading to invasive squamous cell carcinoma. A number of topical therapies are now available for the treatment of AK but their disadvantages include long treatment du...περισσότερα »
Keratoacanthoma (KA)
Keratoacanthoma (KA): An update and review: Keratoacanthoma (KA) is a common but underreported tumor of the skin. Two striking features of KA are its clinical behavior with spontaneous regression after rapid growth and its nosological position on the border between benignity and malignancy. We review current knowledge on the clinical, histopathological, and dermoscopic features of KA to ensure a proper diagnosis and describe its variants, including different types of multiple KAs. We highlight current concepts of KA ethiopathogenesis with special emphasis on the genetic background o...περισσότερα »
Actinic Prurigo (AP)
Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 –2015: Abstract Actinic prurigo (AP) is a chronic photosensitivity disease, which is mainly described in Amerindians and rarely in Caucasians1-6. The pathogenesis of AP is unclear, although familial occurrence is often seen, with a strong association with HLA DR4 and in particular HLA DRB1*0407, which is present only rarely in the general population7,8. This article is protected by copyright. All rights reserved.
Strahlentherapie spinaler Metastasen
Strahlentherapie spinaler Metastasen: Zusammenfassung HintergrundDie Strahlentherapie spielt eine wichtige Rolle im interdisziplinären Management spinaler Metastasen. ZielZiel dieser Arbeit ist eine Übersicht über den klinischen Einsatz der Strahlentherapie im Kontext spinaler Metastasen. Material und MethodenDargestellt werden technische Standards und Innovationen auf Grundlage der gegenwärtigen wissenschaftlichen Evidenz. Auf dieser Basis wird auch die Rolle der Strahlentherapie spinaler Metastasen diskutiert. Ergebnisse und SchlussfolgerungDie Strahlentherapie spinale...περισσότερα »
Developmental trajectories of cerebrovascular reactivity in healthy children and young adults assessed with magnetic resonance imaging
Abstract Cerebrovascular reactivity (CVR) reflects the vasculature's capability to accommodate changes in blood flow demand thereby serving as a critical imaging tool for mapping vascular reserve. Normal development is associated with extensive physiological changes in blood pressure, cerebral blood flow, and cerebral metabolic rate of oxygen, all of which can affect CVR. Moreover, the evolution of these physiological parameters is most prominent during childhood. Therefore, the aim of this study was to use non-invasive magnetic resonance imaging (MRI) to characterize the developme...περισσότερα »
On the mechanism of gating defects caused by the R117H mutation in CFTR
Abstract Cystic fibrosis (CF) is caused by loss-of-function mutations of the CFTR (Cystic Fibrosis Transmembrane conductance Regulator) gene encoding a phosphorylation-activated, but ATP-gated chloride channel. In the current study, we investigated the mechanism responsible for the gating defects manifested in R117H-CFTR, an arginine-to-histidine substitution at position 117 of CFTR that is associated with mild forms of CF. We confirmed previous findings of a 25% decrease of the single-channel conductance (*g*) in R117H-CFTR, but found a ∼13-fold lower open probability (*Po*). Thi...περισσότερα »
Radiation-Induced Breast Angiosarcoma
Radiation-Induced Breast Angiosarcoma: Case Report and Clinical Approach: Importance: Radiation-induced angiosarcoma after conservative treatment of breast cancer affects a small percentage of patients but has a significant impact on survival. Early detection requires a high index of suspicion and is important for optimal management of this aggressive disease. Observations: The patient reported here presented with radiation-induced angiosarcoma of the left breast 14 years after radiation therapy. Histopathology was positive for anti-CD31, anti-CD34, D2-40, and anti–factor VIII (von... περισσότερα »
Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents
Amphetamines for attention deficit hyperactivity disorder (ADHD) in children and adolescents: Abstract Background Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric conditions affecting children and adolescents. Amphetamines are among the most commonly prescribed medications to manage ADHD. There are three main classes of amphetamines: dexamphetamine, lisdexamphetamine and mixed amphetamine salts, which can be further broken down into short- and long-acting formulations. A systematic review assessing their efficacy and safety in this popul...περισσότερα »
Widespread metachronous carcinoid tumour metastases to the head and neck
[image: Magnetic resonance image showing 11mm mass in anterior aspect of left parotid ...] [image: Regular cells with stippled nuclei arranged in small nests (haematoxylin and ...] [image: Granular immunohistochemical staining for synaptophysin (original magnification ...] [image: Computed tomogram showing bilateral parotid metastases (arrowed). Comparison ...] : a unique presentation via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 4 February 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Mohamed Koraitim, Anne V. Spe...περισσότερα »
Clinicopathological analysis of salivary gland tumors
Clinicopathological analysis of salivary gland tumors over a 15-year period: Abstract Salivary gland tumors (SGT) are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group ... περισσότερα »
Peripheral nervous system involvement in primary burning mouth syndrome – results of a pilot study
Peripheral nervous system involvement in primary burning mouth syndrome – results of a pilot study: Abstract Objective The pathophysiology of primary burning mouth syndrome (BMS) has remained enigmatic, but recent studies suggest pathology within the nervous system at multiple levels. This study aimed to investigate in detail the contribution of either focal or generalized alterations within the peripheral nervous system (PNS) in the etiopathogenesis of BMS. Subjects and methods Intraepithelial nerve fiber density (IENFD) of tongue mucosa was assessed in 10 carefully characterized B... περισσότερα »
Infratemporal Fossa Abscess
Infratemporal Fossa Abscess of Dental Origin: A Rare, Severe, and Misdiagnosed Infection.:
Management of Invasive Fungal Sinusitis.
Management of a Rare Case of Invasive Fungal Sinusitis.:
Pathologic Mandibular Fracture as First Sign of Multiple Myeloma.
Pathologic Mandibular Fracture as First Sign of Multiple Myeloma.: Multiple myeloma (MM) is a neoplasia characterized by the proliferation of plasmacytoid cells, which produce abnormal immunoglobulins. It frequently creates local and systemic complications such as pathologic fractures and renal disease. This article reports the case of a 70-year-old man presenting a pathologic fracture of the right mandibular angle secondary to a plasmocytoma. He had a history of a previous pathologic fracture of the left mandibular angle 13 years before that was treated elsewhere, but no documentat... περισσότερα »
Functional Assessments in Patients Undergoing Radial Forearm Flap Following Hemiglossectomy.
Functional Assessments in Patients Undergoing Radial Forearm Flap Following Hemiglossectomy.: Our goal was to evaluate the functional outcomes following radial forearm free-flap reconstruction with a focus on radiotherapy. A 2-year prospective study was performed. A total of 47 patients were enrolled finally. They were asked to complete the swallowing, chewing, speech domains of the University of Washington Quality of Life questionnaire preoperatively and at 2 years postoperatively. Swallowing capacity was apparently affected after surgery, but no patients reported there was chokes ...περισσότερα »
Shape and Height of Tarsal Plates.
Shape and Height of Tarsal Plates.: The aim of this study is to elucidate the anatomic detail of the shape and height of the tarsal plates in Koreans. Fifty-four eyelids from Korean adult cadavers were used. Skin, subcutaneous tissue, and the orbicularis oculi muscle were all removed and the tarsal plates were exposed. The shapes of the tarsal plates were observed and the vertical heights of the tarsal plates were measured at its 1/4 (medial), 2/4 (central), and 3/4 (lateral) horizontal length. Tarsal plates were semilunar shaped and classified into 3 types: symmetric, medially skewed... περισσότερα »
Coexistence of Wormian Bones With Metopism, and Vice Versa, in Adult Skulls.
Coexistence of Wormian Bones With Metopism, and Vice Versa, in Adult Skulls.: Objective: The aim of the study is to investigate coexistence of Wormian bones with metopism, and vice versa, in adult skulls. Materials and Methods: A total of 160 dry adult human skulls of unknown sex and ages were randomly selected from the Gross Anatomy Laboratory of Medical School of Dokuz Eylul University. The skulls were examined for presence of metopism, Wormian bones (WB), and coexistence of WBs with metopism and vice versa. Topographic distribution of the WBs was macroscopically evaluated within t... περισσότερα »
The Coexistence of Rathke Cleft Cyst and Pituitary Adenoma.
The Coexistence of Rathke Cleft Cyst and Pituitary Adenoma.: Both of Pituitary adenoma (PA) and Rathke cleft cyst (RCC) are the most common and benign sellar lesions. Generally, the origin of RCC is considered to be derived from remnants of Rathke punch, while PA is formed by proliferation of the anterior wall of Rathke pouch. Although they have a possibility to share a common embryological origin, the coexistence of PA and RCC is extremely rare. Here, the authors report a 50-year-old male patient who was found to have a large cystic sellar lesion, and surgical resection revealed co... περισσότερα »
Misdiagnosis of Behcet Disease: Should We Examine the Patient's Tongue?.
Misdiagnosis of Behcet Disease: Should We Examine the Patient's Tongue?.:
Swiveling a Single Expanded Forehead Flap: Total Bilateral Upper and Lower Eyelid Reconstruction.
Swiveling a Single Expanded Forehead Flap: A Novel Effective Economical Approach to Total Bilateral Upper and Lower Eyelid Reconstruction.: In our novel approach, a single expanded forehead flap was used to reconstruct bilateral upper and lower eyelids in orbital trauma. A 40-year-old man sustained blast injury resulting in bilateral orbital exenteration and need for bilateral socket and eyelid reconstruction. The sockets were each resurfaced with a temporalis flap. A subgaleal forehead tissue expander was expanded during several weeks until enough tissue was obtained. The single ex... περισσότερα »
Guided bone regeneration, split crest, and autologous bone grafting
Ridge Expansion by Flapless Split Crest and Immediate Implant Placement: Evolution of the Technique.: Various treatment strategies and techniques have been proposed to perform alveolar bone augmentation; most common are guided bone regeneration, split crest, and autologous bone grafting. All of these techniques are reported to possess bone regenerative properties of osteoinduction and osteoconduction in relation to regenerated bone survival. Split crest resulted to be one of the most reliable bone augmentation techniques. In this study, we describe a new flapless-modified split cres...περισσότερα »
Lip Surgery for Cutaneous Carcinoma
Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma: Abstract PurposeThe treatment of lip carcinomas needs tumor surgical resection with safety margins respect. The aim of this study was to report the oncologic and aesthetic/functional outcomes of a retrospective monocentric case series of 39 patients treated for cutaneous lip cancer. MethodsThis retrospective study assessed 56 patients who were treated for a lip carcinoma between 2008 and 2012 and included 39 patients with cutaneous lip basal cell carcinoma or squamous cell carcinoma... περισσότερα »
Miracle cells
for natural dentistry – A review via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 4 February 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Rani Somani, Shipra Jaidka, Neeti Bajaj, Sameksha Arora Stem cells are undifferentiated cells that can differentiate into specialized cells. Recently, enormous growth has been seen in the recognition of stem cell-based therapies, which have the potential to ameliorate the life of patients with conditions that span from Parkinson's disease to cardiac isc... περισσότερα »
3-D Volume Assessment After Fat Repositioning Lower Blepharoplasty
3-D Volume Assessment After Fat Repositioning Lower Blepharoplasty: This electronic medical chart review of 10 patients who had undergone a lower blepharoplasty uses 3-dimentional imaging to examine the results of the fat repositioning technique. *Importance* First reported 3-dimensional quantitative study of the lower periorbital area after lower blepharoplasty using the fat repositioning technique. *Objective* To determine the volumetric effects lower blepharoplasty with fat repositioning provides to the tear trough and deep fat compartments of the upper cheek. *Design, Setti...περισσότερα »
Approach to and Management of the Neutrophilic Dermatoses
Abstract The neutrophilic dermatoses are a related set of disorders that share common features. These disorders are not directly related to infection and are considered forms of “sterile” neutrophilic inflammation. They can occur with an associated systemic disease or as a primary cutaneous process. Subcorneal pustular dermatosis, Sweet’s syndrome, erythema elevatum diutinum, bowel-associated dermatosis-arthritis syndrome,… Continue reading Approach to and Management of the Neutrophilic Dermatoses
Differentiating Skin Rash After Stem Cell Transplantation: Graft Versus Host Disease, Cutaneous Reactions to Drugs and Viral Exanthema
Abstract Hematopoietic stem cell transplant, a life-saving therapeutic option for some patients with malignant and non-malignant disease, may be complicated by a variety of cutaneous and systemic sequelae. Dermatologists are an integral part of the multidisciplinary effort involved in the care of stem cell transplant patients, as skin tissue may be the initial, and/or only,… Continue reading Differentiating Skin Rash After Stem Cell Transplantation: Graft Versus Host Disease, Cutaneous Reactions to Drugs and Viral Exanthema
The Role of Viral Reactivation in Drug Reaction with Eosinophilia and Systemic Symptoms and Other Cutaneous Adverse Drug Reactions (cADRs)
Abstract Cutaneous adverse drug reactions (cADRs) encompass many types of clinical presentations, ranging from benign maculopapular eruption (MPE) to severe cutaneous adverse reactions (SCARs). The relationship between viral reactivation and drug eruptions has been widely observed and has provided a new direction for researchers to explore. In recent years, a number of studies have focused… Continue reading The Role of Viral Reactivation in Drug Reaction with Eosinophilia and Systemic Symptoms and Other Cutaneous Adverse Drug Reactions (cADRs)
Japan Pharmacogenomics Data Science Consortium Database and Its Application for Drug Safety Analyses
Abstract Severe adverse drug reactions (ADRs) are significantly influenced by the genetic background of an individual, and pharmacogenomics (PGx) is strongly expected to reveal the cause of severe ADRs. Genome-wide association studies (GWASs) for severe ADRs have been conducted worldwide, and a genomic database of representative samples of the ethnic population can be used as… Continue reading Japan Pharmacogenomics Data Science Consortium Database and Its Application for Drug Safety Analyses
New scoring system of an interview for the diagnosis of benign paroxysmal positional vertigo.
Conclusion This study investigated a novel instrument to diagnose benign paroxysmal positional vertigo (BPPV). Objective To develop a new scoring system of an interview for the diagnosis of BPPV. Methods The answers to questions on dizziness and/or vertigo (D/V) (571 patients) were analyzed and the questions for which the answers differed significantly between the patients… Continue reading New scoring system of an interview for the diagnosis of benign paroxysmal positional vertigo.
Rate of recurrence and malignant transformation in 88 cases with inverted papilloma between 1998-2008.
Conclusions The recurrence rate of IP in the current study is comparable to international and national studies. When the primary tumour was located in the frontal or the sphenoid sinus, the tumour seemed more likely to recur. Some recurrences were more than 2 years after primary surgery, suggesting continued need for long-term follow-up. The rate… Continue reading Rate of recurrence and malignant transformation in 88 cases with inverted papilloma between 1998-2008.
Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer.
Conclusion Neck dissection after radiotherapy increased the risk of aspiration as a late effect in a sub-sample of patients treated for head and neck cancer in the ARTSCAN study. Patients treated with accelerated fractionation (AF) developed aspiration, with or without coughing, more frequently than patients treated with conventional fractionation (CF). Objectives A long-term follow-up study… Continue reading Aspiration as a late complication after accelerated versus conventional radiotherapy in patients with head and neck cancer.
The Mi1000 CONCERTO PIN cochlear implant: An evaluation of its safety and stability in adults and children.
Conclusion The study demonstrates the medium-term stability and safety of the CONCERTO PIN cochlear implant. The use of the CONCERTO PIN proved to be suitable for the use of a surgical technique without the need for suture fixation and resulted in short surgery duration and a low medium-term complication rate. Objective The primary aim was… Continue reading The Mi1000 CONCERTO PIN cochlear implant: An evaluation of its safety and stability in adults and children.
Medical examination: Preparation for ENT specialisation : Part 23.
Authors: Eichhorn T PMID: 26838170 [PubMed – as supplied by publisher] (Source: HNO) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/20Lc8n0 via IFTTT
Acknowledgement to referees 2015
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Midline Corset Platysmaplasty and Degree of Lift in Deep-Plane Face-lift
Midline Corset Platysmaplasty and Degree of Lift in Deep-Plane Face-lift: This cadaveric study examines the effect of midline corset platysmaplasty on the degree of lift obtained in deep-plane face-lift. *Importance* The evaluation of the effects of midline platysmaplasty concomitant with rhytidectomy. *Objective* To determine whether midline platysmaplasty limits the degree of lift during deep-plane face-lift. *Design, Setting, and Participants* Deep-plane rhytidectomy was performed on 10 cadaveric hemifaces. The redundant skin for excision after performing the face-lift was m... περισσότερα »
Diabetic Osteomyelitis
Surgical treatment strategy for diabetic forefoot osteomyelitis: Abstract The aim of this study was to propose an appropriate surgical treatment for diabetic forefoot osteomyelitis (DFO) involving ischemia or moderate to severe soft tissue infection. The records of 28 patients with osteomyelitis from 2009–2015 were retrospectively studied. All patients had undergone surgery based on pre-operative magnetic resonance imaging examinations and histopathological or culture analyses confirming the surgical bone margin. The appropriate surgical margin, crucial factors for early healing, an... περισσότερα »
The application of acellular matrices, biomaterials, and polymeric scaffolds in reconstructive surgery
In vivo characterization of the integration and vascularization of a silk-derived Surgical Scaffold via British Association of Plastic Surgeons Publication date: Available online 5 February 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Monika Kijanska, Anastasios Marmaras, Alicia Hegglin, Vartan Kurtcuoglu, Pietro Giovanoli, Nicole Lindenblatt BackgroundThe application of acellular matrices, biomaterials, and polymeric scaffolds in reconstructive surgery facilitates post-surgical tissue remodeling and is increasingly used clinically in order to improve ... περισσότερα »
Efficacy of one-stage surgical treatment and clinical features in patients with multiple pressure ulcers
Efficacy of one-stage surgical treatment and clinical features in patients with multiple pressure ulcers: Abstract Treating patients with multiple pressure ulcers is a very challenging task for physicians. However, there are very few reports on treatment protocols for multiple pressure ulcers and treatment outcomes. The authors have consistently treated multiple pressure ulcers in a one-stage operation rather than a staged operation. We evaluated multiple pressure ulcers patients who underwent a one-stage operation from 2007 to 2014. A comparison was made between 20 patients who un... περισσότερα »
The effect of diabetes on the wound healing potential of adipose-tissue derived stem cells
The effect of diabetes on the wound healing potential of adipose-tissue derived stem cells: Abstract To investigate whether diabetes mellitus affects the wound-healing-promoting potential of adipose tissue-derived stem cells, we designed a wound-healing model using diabetic mice. We compared the degree of wound healing between wounds treated with normal adipose tissue-derived stem cells and wounds treated with diabetic adipose tissue-derived stem cells. We evaluated the wound-healing rate, the epithelial tongue distance, the area of granulation tissue, the number of capillary and t... περισσότερα »
Pain and skin tearing at dressing change
A descriptive study of Korean nurses' perception of pain and skin tearing at dressing change: Abstract This study aimed to investigate Korean nurses' level of awareness of pain and skin tearing in wound bed and/or peri-wound skin at dressing change. A descriptive study was performed. Convenience sampling was employed and registered nurses were recruited from attendees of continuing education program. A total of 399 participants (RN) completed questionnaire. Data was collected from September to November 2014. Many of them perceived skin tearing and wound related pain associated with...περισσότερα »
Role of TRP ion channels in cancer and tumorigenesis
Role of TRP ion channels in cancer and tumorigenesis: AbstractTransient receptor potential (TRP) channels are recently identified proteins that form a versatile family of ion channels, the majority of which are calcium permeable and exhibit complex regulatory patterns with sensitivity to multiple environmental factors. While this sensitivity has captured early attention, leading to recognition of TRP channels as environmental and chemical sensors, many later studies concentrated on the regulation of intracellular calcium by TRP channels. Due to mutations, dysregulation of ion chann... περισσότερα »
Airway management and training in anaesthesia
Airway management and training in obstetric anaesthesia.: Purpose of review: Airway management and failed intubation in the pregnant woman requires unique considerations, which differ from the nonpregnant patient. Factors that influence airway management in this setting include anatomical and physiological changes in pregnancy, environmental factors as well as training matters. In addition, surgery is often being performed with extreme urgency, which requires rapid decision-making process that takes into account safe outcome of mother and baby. The purpose of this review is to focus... περισσότερα »
Perioperative bleeding management in pediatric patients.τhe diagnosis and treatment of anemia and coagulopathy with the transfusion of blood products
Perioperative bleeding management in pediatric patients.: Purpose of review: Managing the bleeding pediatric patient perioperatively can be extremely challenging. The primary goals include avoiding hypotension, maintaining adequate tissue perfusion and oxygenation, and maintaining hemostasis. Traditional bleeding management has consisted of transfusion of autologous blood products, however, there is strong evidence that transfusion-related side-effects are associated with increased morbidity and mortality in children. Especially concerning is the increased reported incidence of noni...περισσότερα »
Comparison of EASYPREP® and SurePath® in thyroid fine-aspiration
Comparison of EASYPREP® and SurePath® in thyroid fine-aspiration: Background While fine-needle aspiration cytology (FNAC) using conventional smear has been widely accepted as the primary diagnostic tool for thyroid lesions, liquid-based preparations (LBPs) are increasingly replacing it. A new automated LBP method, EASYPREP® (EP), was recently introduced and has shown relevant diagnostic efficacy in gynecologic samples. We compared the diagnostic utility of EP and SurePath® (SP), a more widely established LBP method, in thyroid FNAC. Methods Under the ultrasonographic guidance, 253 t... περισσότερα »
Retrospective review of the incidence of monitoring blood glucose levels in patients receiving corticosteroids with systemic anticancer therapy.
[image: http:--http://ift.tt/1PYzrrL] Related Articles *Retrospective review of the incidence of monitoring blood glucose levels in patients receiving corticosteroids with systemic anticancer therapy.* Ann Palliat Med. 2015 Apr;4(2):70-7 Authors: Rowbottom L, Stinson J, McDonald R, Emmenegger U, Cheng S, Lowe J, Giotis A, Cheon P, Chow R, Pasetka M, Thavarajah N, Pulenzas N, Chow E, DeAngelis C Abstract BACKGROUND: Corticosteroids are used adjuvant to certain chemotherapy regimens, either as an antiemetic, to reduce other side effects, or to enhance cancer treatment. Additionally... περισσότερα »
Proteasome inhibitors as experimental therapeutics of autoimmune diseases.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Proteasome inhibitors as experimental therapeutics of autoimmune diseases.* Arthritis Res Ther. 2015;17:17 Authors: Verbrugge SE, Scheper RJ, Lems WF, de Gruijl TD, Jansen G Abstract Current treatment strategies for rheumatoid arthritis (RA) consisting of disease-modifying anti-rheumatic drugs or biological agents are not always effective, hence driving the demand for new experimental therapeutics. The antiproliferative capacity of proteasome inhibitors (PIs) has received considerable at... περισσότερα »
Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma.* Curr Opin Gastroenterol. 2015 May;31(3):264-8 Authors: Borad MJ, Gores GJ, Roberts LR Abstract PURPOSE OF REVIEW: This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA). RECENT FINDINGS: Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications o... περισσότερα »
Genomic analysis of metastatic cutaneous squamous cell carcinoma.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Genomic analysis of metastatic cutaneous squamous cell carcinoma.* Clin Cancer Res. 2015 Mar 15;21(6):1447-56 Authors: Li YY, Hanna GJ, Laga AC, Haddad RI, Lorch JH, Hammerman PS Abstract PURPOSE: A rare 5% of cutaneous squamous cell carcinomas (cSCC) metastasize, lack FDA-approved therapies, and carry a poor prognosis. Our aim was to identify recurrent genomic alterations in this little-studied population of metastatic cSCCs. EXPERIMENTAL DESIGN: We performed targeted sequencing of 504 cancer-associated genes on ... περισσότερα »
Screening of Drug Metabolizing Enzymes for the Ginsenoside Compound K In Vitro: An Efficient Anti-Cancer Substance Originating from Panax Ginseng.
*Screening of Drug Metabolizing Enzymes for the Ginsenoside Compound K In Vitro: An Efficient Anti-Cancer Substance Originating from Panax Ginseng.* PLoS One. 2016;11(2):e0147183 Authors: Xiao J, Chen D, Lin XX, Peng SF, Xiao MF, Huang WH, Wang YC, Peng JB, Zhang W, Ouyang DS, Chen Y Abstract Ginsenoside compound K (CK), a rare ginsenoside originating from Panax Ginseng, has been found to possess unique pharmacological activities specifically as anti-cancers. However, the role of cytochrome P450s (CYPs) in the metabolism of CK is unclear. In this study, we screened the CYPs for t... περισσότερα »
upper respiratory tract infection; +86 new citations
86 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/02/05 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1K2nu23 via IFTTT
Liver Fibrosis Staging with MR Elastography: Comparison of Diagnostic Performance between Patients with Chronic Hepatitis B and Those with Other Etiologic Causes.
*Liver Fibrosis Staging with MR Elastography: Comparison of Diagnostic Performance between Patients with Chronic Hepatitis B and Those with Other Etiologic Causes.* Radiology. 2016 Feb 4;:150397 Authors: Chang W, Lee JM, Yoon JH, Han JK, Choi BI, Yoon JH, Lee KB, Lee KW, Yi NJ, Suh KS Abstract Purpose To evaluate the diagnostic performance of magnetic resonance (MR) elastography in staging liver fibrosis in patients with chronic hepatitis B (CHB) and other etiologic causes. Materials and Methods This retrospective study was institutional review board-approved and the requirement ...περισσότερα »
An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging.
*An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging.* Radiology. 2016 Feb 3;:142529 Authors: Ahmadi E, Katnani HA, Daftari Besheli L, Gu Q, Atefi R, Villeneuve MY, Eskandar E, Lev MH, Golby AJ, Gupta R, Bonmassar G Abstract Purpose To develop an electrocorticography (ECoG) grid by using deposition of conductive nanoparticles in a polymer thick film on an organic substrate (PTFOS) that induces minimal, if any, artifacts on computed tomographic (CT) and magnetic resonance (MR) images and is safe in te... περισσότερα »
Transoral robotic resection of a large schwannoma in the retropharyngeal space
Short CommunicationTransoral robotic resection of a large schwannoma in the retropharyngeal spaceA Gungadeena1 c1, R Lissetera1, J Manickavasagama2 and V Paleria1 a1 Department of Otolaryngology and Head and Neck Surgery, Freeman Hospital, Newcastle upon Tyne, UK a2 Department of Otolaryngology and Head and Neck Surgery, Ninewells Hospital, Dundee, Scotland, UK Abstract Background: External approaches have been traditionally used for the complete excision of large retropharyngeal space lesions. Case report: This paper describes a case of a large schwannoma of the retropharyngeal space... περισσότερα »
Is the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literature
Main ArticleIs the effect of topical intranasal steroids on obstructive adenoids transient or long-lasting? Case series and systematic review of literatureM A Bitara1a2a3a4 c1, J Nassara1a5 and R Danaa6 a1 Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine and Medical Center, American University of Beirut, Lebanon a2 Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and Medical Center, American University of Beirut, Lebanon a3 Department of ENT Surgery, Children's Hospital at Westmead, Sydney, Australia a4 Pediatric Otolaryngology Program, Al Ja... περισσότερα »
Radiofrequency ablation in the management of retropharyngeal lymphatic malformation
Value of via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Quentin Lisan, Aude Villepelet, Marine Parodi, Eréa-Noël Garabedian, Marie Julie Blouin, Vincent Couloigner, Nicolas Leboulanger Lymphatic malformations are benign malformations frequently occurring in the head and neck. Retropharyngeal location is rare, can be life threating and its management is particularly challenging. Over a three-year period, three patients presented with symptomatic (dyspnea and/or ...περισσότερα »
Chronic sclerosing sialadenitis of the parotid gland
Uncommon situation and presentation of chronic sclerosing sialadenitis via International Journal of Pediatric Otorhinolaryngology Publication date: April 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): T. Adouly, C. Adnane, Y. Housni, S. Rouadi, R. Abada, M. Roubal, M. Mahtar Chronic sclerosing sialadenitis of the parotid gland is a very uncommon chronic inflammatory salivary gland disease. Clinically, it presents as a slow-growing painful. Histologically, it showed a chronic inflammation and fibrosis. This case report highlights the clinical, ... περισσότερα »
Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.
[image: http:--production.springer.de-OnlineReso] Related Articles *Mechanism of tumor remission by cytomegalovirus in a murine lymphoma model: evidence for involvement of virally induced cellular interleukin-15.* Med Microbiol Immunol. 2015 Jun;204(3):355-66 Authors: Erlach KC, Reddehase MJ, Podlech J Abstract A murine model of B and T cell lymphomas in recipients after hematoablative conditioning for hematopoietic cell transplantation (HCT) has previously revealed a tumor-repressive, metastasis-inhibiting function of murine cytomegalovirus (mCMV). More recently, this prediction ... περισσότερα »
Steroid-responsive atypical marginal zone hyperplasia of the lip in a child.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Steroid-responsive atypical marginal zone hyperplasia of the lip in a child.* Am J Dermatopathol. 2015 Apr;37(4):e45-8 Authors: Sedrak M, Muthukumar A, Elghetany MT, Qian YW Abstract Atypical marginal zone hyperplasia (AMZH) is a recently described disease entity seen mainly in children. AMZH most commonly affects tonsils and appendices. Cutaneous AMZH is rare. The authors report here a recurrent AMZH in the lip of a 9-year-old child who presented originally with a lip swelling for approximately 3 months. The lip... περισσότερα »
Comparative efficacy of 177Lu and 90Y for anti-CD20 pretargeted radioimmunotherapy in murine lymphoma xenograft models.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Comparative efficacy of 177Lu and 90Y for anti-CD20 pretargeted radioimmunotherapy in murine lymphoma xenograft models.* PLoS One. 2015;10(3):e0120561 Authors: Frost SH, Frayo SL, Miller BW, Orozco JJ, Booth GC, Hylarides MD, Lin Y, Green DJ, Gopal AK, Pagel JM, Bäck TA, Fisher DR, Press OW Abstract PURPOSE: Pretargeted radioimmunotherapy (PRIT) is a multi-step method of selectively delivering high doses of radiotherapy to tumor cells while minimizing exposure to surrounding tissues. Ytt... περισσότερα »
Phase I study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Phase I study of a bispecific ligand-directed toxin targeting CD22 and CD19 (DT2219) for refractory B-cell malignancies.* Clin Cancer Res. 2015 Mar 15;21(6):1267-72 Authors: Bachanova V, Frankel AE, Cao Q, Lewis D, Grzywacz B, Verneris MR, Ustun C, Lazaryan A, McClune B, Warlick ED, Kantarjian H, Weisdorf DJ, Miller JS, Vallera DA Abstract PURPOSE: The novel bispecific ligand-directed toxin (BLT) DT2219 consists of a recombinant fusion between the catalytic and translocation enhancing domain of diphtheria toxin (...περισσότερα »
[Positron emission tomography in primary brain lymphoma: Diagnostic and prognostic significance].
Related Articles *[Positron emission tomography in primary brain lymphoma: Diagnostic and prognostic significance].* Med Clin (Barc). 2015 Jun 8;144(11):501-2 Authors: Canales Albendea MÁ PMID: 25765581 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1nLvLNe via IFTTT
Primary hepatic diffuse large B-cell lymphoma: unusual presentation and imaging features.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Primary hepatic diffuse large B-cell lymphoma: unusual presentation and imaging features.* Curr Probl Diagn Radiol. 2015 May-Jun;44(3):290-3 Authors: Dhamija E, Madhusudhan KS, Shalimar, Das P, Srivastava DN, Gupta AK Abstract Primary hepatic lymphoma is an uncommon malignancy affecting the liver, with limited reports and series in the literature. Imaging appearance is not well described, with no definite features suggesting a diagnosis, and it may mimic other focal hepatic lesions. However, biopsy is needed in mo... περισσότερα »
Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Clinical and biological effects of an agonist anti-CD40 antibody: a Cancer Research UK phase I study.* Clin Cancer Res. 2015 Mar 15;21(6):1321-8 Authors: Johnson P, Challis R, Chowdhury F, Gao Y, Harvey M, Geldart T, Kerr P, Chan C, Smith A, Steven N, Edwards C, Ashton-Key M, Hodges E, Tutt A, Ottensmeier C, Glennie M, Williams A Abstract PURPOSE: This phase I study aimed to establish the biologic effects and MTD of the agonistic IgG1 chimeric anti-CD40 antibody ChiLob7/4 in patients (pts) with a range of CD40-ex...περισσότερα »
A comparative study of molecular characteristics of diffuse large B-cell lymphoma from patients with and without human immunodeficiency virus infection.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *A comparative study of molecular characteristics of diffuse large B-cell lymphoma from patients with and without human immunodeficiency virus infection.* Clin Cancer Res. 2015 Mar 15;21(6):1429-37 Authors: Chao C, Silverberg MJ, Xu L, Chen LH, Castor B, Martínez-Maza O, Abrams DI, Zha HD, Haque R, Said J Abstract PURPOSE: HIV-related diffuse large B-cell lymphoma (DLBCL) may be biologically different from DLBCL in the general population. We compared, by HIV status, the expression and prognostic significance of se... περισσότερα »
Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis.
[image: http:--production.springer.de-OnlineReso] Related Articles *Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis.* Cell Oncol (Dordr). 2015 Apr;38(2):93-109 Authors: Shahjahani M, Mohammadiasl J, Noroozi F, Seghatoleslami M, Shahrabi S, Saba F, Saki N Abstract BACKGROUNDS: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults and is characterized by a clonal accumulation of mature apoptosis-resistant neoplastic cells. It is also a heterogeneous disease with a variable clinical outcome. Here, we present a review of currently kn... περισσότερα »
[Positron emission tomography combined with computed tomography in the initial evaluation and response assessment in primary central nervous system lymphoma].
Related Articles *[Positron emission tomography combined with computed tomography in the initial evaluation and response assessment in primary central nervous system lymphoma].* Med Clin (Barc). 2015 Jun 8;144(11):503-6 Authors: Mercadal S, Cortés-Romera M, Vélez P, Climent F, Gámez C, González-Barca E Abstract OBJECTIVE: To evaluate the role of positron emission tomography combined with computed tomography (PET-CT) in the initial evaluation and response assessment in primary central nervous system lymphoma (PCNSL). MATERIAL AND METHOD: Fourteen patients (8 males) with a median a... περισσότερα »
Added predictive value of omics data: specific issues related to validation illustrated by two case studies.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Added predictive value of omics data: specific issues related to validation illustrated by two case studies.* BMC Med Res Methodol. 2014;14:117 Authors: De Bin R, Herold T, Boulesteix AL Abstract BACKGROUND: In the last years, the importance of independent validation of the prediction ability of a new gene signature has been largely recognized. Recently, with the development of gene signatures which integrate rather than replace the clinical predictors in the prediction rule, the focus h... περισσότερα »
Late-onset IgA vasculitis in adults
Clin Exp Rheumatol. 2016 Jan 26. [Epub ahead of print] Late-onset IgA vasculitis in adult patients exhibits distinct clinical characteristics and outcomes. Hong S1, Ahn SM1, Lim DH1, Ghang B1, Yang WS2, Lee SK2, Kim YG1, Lee CK1, Yoo B3. Author information 1Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 2Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. 3Division of Rheumatology, Department of Internal Medicine, Univer...περισσότερα »
Non-typeable Haemophilus influenzae purulent pericarditis in a child with cystic fibrosis
Pediatr Int. 2016 Feb 4. doi: 10.1111/ped.12850. [Epub ahead of print] Downes KJ1, Abulebda K2, Siracusa C3, Moore R4, Staat MA1, Poynter SE2. Author information 1Divisions of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 2Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 4Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. Abstract Early airway...περισσότερα »
Reducing antibiotic prescriptions for respiratory tract infections
NPJ Prim Care Respir Med. 2016 Feb 4;26:15083. doi: 10.1038/npjpcrm.2015.83. Reducing antibiotic prescriptions for respiratory tract infections in family practice: results of a cluster randomized controlled trial evaluating a multifaceted peer-group-based intervention. Vervloet M1, Meulepas MA2,3, Cals JW4, Eimers M2, van der Hoek LS1, van Dijk L1. Author information 1NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands. 2Dutch Institute for Rational Use of Medicine, Utrecht, The Netherlands. 3Meetpunt Kwaliteit, Eindhoven, The Netherlands. 4Department of ...περισσότερα »
Editorial board
Publication date: March–April 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 2 from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1oc98lt via IFTTT
Experimental set up for the irradiation of biological samples and nuclear track detectors with UV C
Publication date: March–April 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 2 Author(s): Agustina Mariana Portu, Andrés Eugenio Rossini, Mario Alberto Gadan, Omar Alberto Bernaola, Silvia Inés Thorp, Paula Curotto, Emiliano César Cayetano Pozzi, Rómulo Luis Cabrini, Gisela Saint Martin AimIn this work we present a methodology to produce an "imprint" of cells cultivated on a polycarbonate detector by exposure of the detector to UV C radiation.BackgroundThe distribution and concentration of 10B atoms in tissue samples coming from BNCT (Boron Neutron Captu... περισσότερα »
Microdosimetry: Principles and applications
Publication date: March–April 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 2 Author(s): Gustavo A. Santa Cruz Aimto present the most important aspects of Microdosimetry, a research field in radiation biophysics.Backgroundmicrodosimetry is the branch of radiation biophysics that systematically studies the spatial, temporal and spectral aspects of the stochastic nature of the energy deposition processes in microscopic structures.Materials and Methodswe briefly review its history, the people, the formalism and the theories and devices that allowed resear... περισσότερα »
CCR4 frameshift mutation identifies a distinct group of adult T-cell leukemia/lymphoma with poor prognosis
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Adult T-cell leukemia/lymphoma (ATLL) is an intractable T-cell neoplasm caused by human T-cell leukemia virus type 1. Next generation-sequencing-based comprehensive mutation studies have revealed recurrent somatic *CCR4* mutations in ATLL, although clinicopathological findings associated with *CCR4* mutations remain to be delineated. In the current study, 184 cases of peripheral T-cell lymphoma, including 113 cases of ATLL were subjected to *CCR4* mutation analysis. This sequence analysis identified mutations in 27% (30/1... περισσότερα »
On the mechanism of gating defects caused by the R117H mutation in CFTR
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Abstract Cystic fibrosis (CF) is caused by loss-of-function mutations of the CFTR (Cystic Fibrosis Transmembrane conductance Regulator) gene encoding a phosphorylation-activated, but ATP-gated chloride channel. In the current study, we investigated the mechanism responsible for the gating defects manifested in R117H-CFTR, an arginine-to-histidine substitution at position 117 of CFTR that is associated with mild forms of CF. We confirmed previous findings of a 25% decrease of the single-channel conductance (*g*) in R117H-CFTR, but found a ∼13-fold lower open probability (*Po*). Thi...περισσότερα »
Endothelin-1 modulates methacholine-induced cutaneous vasodilation but not sweating in young human skin
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Abstract The present study investigated the effect of endothelin-1 (ET-1) on cholinergic mechanisms of end-organs (i.e. skin blood vessels and sweat glands) for heat dissipation. We evaluated the hypothesis that ET-1 attenuates cholinergic cutaneous vasodilation and sweating through a NO synthase (NOS)-dependent mechanism. Cutaneous vascular conductance (CVC) and sweat rate were assessed in three protocols: in Protocol 1 (n = 8), microdialysis sites were perfused with lactated Ringer (Control), 40pM, 4 nM or 400 nM ET-1; in Protocol 2 (n = 11) sites were perfused with lactated Ri... περισσότερα »
Notch regulation of gastrointestinal stem cells
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Abstract The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem and progenitor cells. These cell compartments are regulated to balance proliferation and stem cell renewal with differentiation into the various mature cell types to maintain tissue homeostasis. In this topical review we focus on the role of the Notch signaling pathway to regulate GI stem cell function in adult small intestine and stomach. We first present the current view of stem and progenitor cell populations in these tissues and then summarize the studies that have establi... περισσότερα »
Lessons from computer simulations of ablation of atrial fibrillation
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Abstract This paper reviews the simulations of catheter ablation in computer models of the atria, from the first attempts to the most recent anatomical models. It describes how postulated substrates of atrial fibrillation can be incorporated into mathematical models, how modeling studies can be designed to test ablation strategies, what their current trade-offs and limitations are, and what clinically relevant lessons can be learnt from these simulations. Drawing a parallel between clinical and modeling studies, six ablation targets are considered: pulmonary vein isolation, linear... περισσότερα »
Molecules, Vol. 21, Pages 195: The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-κB Pathway
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Naringin has been reported to have an anti-atherosclerosis effect but the underlying mechanism is not fully understood. The aim of this study is to investigate the impact of naringin on the TNF-α-induced expressions of cell adhesion molecules, chemokines and NF-κB signaling pathway in human umbilical vein endothelial cells (HUVECs). The experiments revealed that naringin, at concentrations without cytotoxicity, dose-dependently inhibited the adhesion of THP-1 monocytes to the TNF-α-stimulated HUVECs. The TNF-α-induced expressions of cell adhesion molecules, including VCAM-1, ICAM-...περισσότερα »
Viruses, Vol. 8, Pages 45: Big Data Offers Novel Insights for Oncolytic Virus Immunotherapy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Large-scale assays, such as microarrays, next-generation sequencing and various "omics" technologies, have explored multiple aspects of the immune response following virus infection, often from a public health perspective. Yet a lack of similar data exists for monitoring immune engagement during oncolytic virus immunotherapy (OVIT) in the cancer setting. Tracking immune signatures at the tumour site can create a snapshot or longitudinally analyse immune cell activation, infiltration and functionality within global populations or individual cells. Mapping immune changes over the co...περισσότερα »
Sustainability, Vol. 8, Pages 156: Proactive Environmental Strategy, Technological Eco-Innovation and Firm Performance—Case of Poland
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Nowadays, scholars exploring the relationship between proactive environmental strategy and firm competitiveness do not focus on the question of whether it pays to be green but rather investigate when, for whom or how it does so. This paper analyzes the links between proactive environmental strategy, technological eco-innovation and firm performance. In particular, it examines the influence of proactive environmental strategy on firm performance and explores this relationship through technological eco-innovation. A research model has been developed and tested using a sample of 292 ...περισσότερα »
Molecules, Vol. 21, Pages 194: Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex “Clicked” to a Lipidated Tat Peptide
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
A new bifunctional macrocyclic chelator featuring a conjugatable alkynyl-naphthalimide fluorophore pendant group has been prepared and its Gd(III) complex coupled to a cell-penetrating lipidated azido-Tat peptide derivative using Cu(I)-catalysed "click" chemistry. The resulting fluorescent conjugate is able to enter CAL-33 tongue squamous carcinoma cells, as revealed by confocal microscopy, producing a very modest anti-proliferative effect (IC50 = 93 µM). Due to the photo-reactivity of the naphthalimide moiety, however, the conjugate's cytotoxicity is significantly enhanced (IC50 ... περισσότερα »
IJMS, Vol. 17, Pages 217: Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis?
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways. In this review we discuss the rapidly expanding body of clinical and epidemiological evidence supporting a strong association between NAFLD and chronic plaque psoriasis. We also briefly discuss the possible biological mechanisms underlying this association, and discuss treatment options for psoriasis that may influence NAF...περισσότερα »
Marine Drugs, Vol. 14, Pages 35: Potential Anti-Atherosclerotic Properties of Astaxanthin
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density ... περισσότερα »
Marine Drugs, Vol. 14, Pages 34: Marine Origin Polysaccharides in Drug Delivery Systems
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as...περισσότερα »
IJMS, Vol. 17, Pages 214: Generation of Potent Anti-Vascular Endothelial Growth Factor Neutralizing Antibodies from Mouse Phage Display Library for Cancer Therapy
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Vascular endothelial growth factor (VEGF) is an important stimulator for angiogenesis in solid tumors. Blocking VEGF activity is an effective therapeutic strategy to inhibit tumor growth and metastasis. Avastin, a humanized monoclonal antibody recognizes VEGF, has been approved by the US Food and Drug Administration. To generate potential VEGF-recognizing antibodies with better tumor regression ability than that of Avastin, we have designed a systematic antibody selection plan. From mice immunized with recombinant human VEGF, we generated three phage display libraries, scFv-M13KO7... περισσότερα »
IJMS, Vol. 17, Pages 211: The Effect of Small Cosolutes that Mimic Molecular Crowding Conditions on the Stability of Triplexes Involving Duplex DNA
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Triplex stability is studied in crowding conditions using small cosolutes (ethanol, acetonitrile and dimethylsulfoxide) by ultraviolet (UV), circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopies. The results indicate that the triplex is formed preferentially when the triplex forming oligonucleotide (TFO) is RNA. In addition, DNA triplexes (D:D·D) are clearly less stable in cosolute solutions while the stability of the RNA triplexes (R:D·D) is only slightly decreased. The kinetic of triplex formation with RNA-TFO is slower than with DNA-TFO and the thermal sta... περισσότερα »
Molecules, Vol. 21, Pages 193: Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide. Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase (AChE) in order to increase the concentration of acetylcholine in the synaptic cleft. Evidence indicates that AChE also interacts with the β-amyloid (Aβ) protein, acting as a chaperone and increasing the number and neurotoxicity of Aβ fibrils. It is known that AChE has two binding sites: the peripheral site, responsible for the interactions with Aβ, and the catalytic site, related with acetylcholine hydr... περισσότερα »
Sustainability, Vol. 8, Pages 149: Geographical Detector Model for Influencing Factors of Industrial Sector Carbon Dioxide Emissions in Inner Mongolia, China
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Studying the influencing factors of carbon dioxide emissions is not only practically but also theoretically crucial for establishing regional carbon-reduction policies, developing low-carbon economy and solving the climate problems. Therefore, we used a geographical detector model which is consists of four parts, i.e., risk detector, factor detector, ecological detector and interaction detector to analyze the effect of these social economic factors, i.e., GDP, industrial structure, urbanization rate, economic growth rate, population and road density on the increase of energy consu... περισσότερα »
Meta-analysis of drain amylase content on postoperative day 1 as a predictor of pancreatic fistula following pancreatic resection
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
British Journal of Surgery from #Medicine via ola Kala on Inoreader http://ift.tt/20L4EQL via IFTTT
Sofosbuvir based treatment is safe and effective in patients with chronic hepatitis C infection and end-stage renal disease: a case series
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Liver International from #Medicine via ola Kala on Inoreader http://ift.tt/20L4EAr via IFTTT
Nucleotide-binding oligomerization domain 1 acts in concert with the cholecystokinin receptor agonist, cerulein, to induce IL-33-dependent chronic pancreatitis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Mucosal Immunology from #Medicine via ola Kala on Inoreader http://ift.tt/1oc2bB6 via IFTTT
Systematic review with network meta-analysis: comparative effectiveness of topical steroids vs. PPIs for the treatment of the spectrum of eosinophilic oesophagitis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Alimentary Pharmacology and Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/20L4Hfq via IFTTT
Surgical outcomes of hepatocellular carcinoma with biliary tumor thrombus: a systematic review
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
BMC Gastroenterology from #Medicine via ola Kala on Inoreader http://ift.tt/20L4GZ6 via IFTTT
Does Vitamin D3 Have an Impact on Clinical and Biochemical Parameters Related to Third Molar Surgery.
The purpose of this study was to evaluate the clinical effect on the biochemical inflammatory markers of a single oral high dose of cholecalciferol in vitamin D-deficient patients undergoing the surgical removal of lower third molars. A randomized, split-mouth, single-blind study was conducted on 25 vitamin D-deficient patients ranging between 18 and 40 years of age requiring lower third molars extraction and referred at the Oral Surgery Unit of the School of Dentistry of the University of Messina. All patients, with vitamin D3 blood levels [less than over equal to]30 ng/mL, underwe... περισσότερα »
Management of a Rare Case of Invasive Fungal Sinusitis.
No abstract available from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1L2ijtO via IFTTT
Infratemporal Fossa Abscess of Dental Origin: A Rare, Severe, and Misdiagnosed Infection.
No abstract available from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1L2iiGc via IFTTT
Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma
Abstract Purpose The treatment of lip carcinomas needs tumor surgical resection with safety margins respect. The aim of this study was to report the oncologic and aesthetic/functional outcomes of a retrospective monocentric case series of 39 patients treated for cutaneous lip cancer. Methods This retrospective study assessed 56 patients who were treated for a lip carcinoma between 2008 and 2012 and included 39 patients with cutaneous lip basal cell carcinoma or squamous cell carcinoma. Clinical, surgical and pathological data were reviewed, and patients were interviewed for follo... περισσότερα »
Predicting Periodontitis at State and Local Levels in the United States
The objective of the study was to estimate the prevalence of periodontitis at state and local levels across the United States by using a novel, small area estimation (SAE) method. Extended multilevel regression and poststratification analyses were used to estimate the prevalence of periodontitis among adults aged 30 to 79 y at state, county, congressional district, and census tract levels by using periodontal data from the National Health and Nutrition Examination Survey (NHANES) 2009–2012, population counts from the 2010 US census, and smoking status estimates from the Behavioral... περισσότερα »
Dental Surface Texture Characterization Based on Erosive Tooth Wear Processes
The differential diagnosis of dental wear lesions affects their clinical management. We hypothesized that surface texture parameters can differentiate simulated erosion, abrasion, and erosion-abrasion lesions on human enamel and dentin. This in vitro study comprised 2 parts (both factorial 4 x 2), with 4 lesion types (erosion, abrasion, erosion-abrasion, and sound [no lesion; control]) and 2 substrates (enamel and dentin). Flattened/polished dental specimens were used in part 1, whereas natural dental surfaces were used in part 2. Testing surfaces were evaluated in blind condition... περισσότερα »
Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis
Summary Palmoplantar pustulosis (PPP) is a chronic pustular dermatitis of the palms and soles, which is frequently associated with significant pruritus and pain, often limiting daily activities. We present the case of a 36-year-old man with severe PPP who had treatment failure with multiple medical therapies but showed marked improvement with high-dose rate brachytherapy. Brachytherapy has the advantage of providing a conformal dose distribution over complex curved surfaces, such as the foot and ankle. Our observations suggest that brachytherapy may be a well-tolerated treatment op...περισσότερα »
The distribution of epidermolysis bullosa in Australia with a focus on rural and remote areas
Abstract Background/Objectives Patients with epidermolysis bullosa (EB) require specialised medical care. In Australia this expertise is located in the major cities, with patients living in rural and remote areas having reduced access to these services. We aim to analyse the geographical distribution of patients with EB in Australia to determine the relevance of this potential geographical disadvantage for this population. Methods Using postal codes obtained from the Australian National Diagnostic Laboratory Database for EB and the Australasian EB Registry, living patients with ... περισσότερα »
Biomarkers of oxidative stress and metal accumulation in marsh frog ( Pelophylax ridibundus )
Abstract To understand the effect of metals on the marsh frog *Pelophylax ridibundus* and the possible environment-induced changes in oxidative stress enzymes, we determined the concentrations of 18 metals: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, In, Li, Mn, Ni, Pb, Sr, and Zn, in the tissues (liver, skin, and muscle) and water samples collected from different locations in Serbia. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione *S*-transferase (GST), acetylcholinesterase (AChE), and changes i... περισσότερα »
Degradation and detoxification of the triphenylmethane dye malachite green catalyzed by crude manganese peroxidase from Irpex lacteus F17
Abstract Malachite green (MG), a recalcitrant, carcinogenic, and mutagenic triphenylmethane dye, was decolorized and detoxified using crude manganese peroxidase (MnP) prepared from the white rot fungus *Irpex lacteus* F17. In this study, the key factors (pH, temperature, MG, Mn2+, H2O2, MnP) in these processes were investigated. Under optimal conditions, 96 % of 200 mg L−1 of MG was decolorized when 66.32 U L−1 of MnP was added for 1 h. The *K* m, *V* max, and *k* cat values were 109.9 μmol L−1, 152.8 μmol L−1 min−1, and 44.5 s−1, respectively. The decolorization of MG by MnP follo...περισσότερα »
Spatial-temporal dynamics and sources of total Hg in a hydroelectric reservoir in the Western Amazon, Brazil
Abstract Damming rivers to construct hydroelectric reservoirs results in a series of impacts on the biogeochemical Hg cycle. For example, modifying the hydrodynamics of a natural watercourse can result in the suspension and transport of Hg deposits in the water column, which represents an exposure risk for biota. The objective of this study was to evaluate the influences of seasonality on the dispersion of total Hg in the Hydroelectric Power Plant (HPP)-Samuel Reservoir (Porto Velho/Brazil). Sampling campaigns were performed during the three following hydrological periods character... περισσότερα »
The applied indicators of water quality may underestimate the risk of chemical exposure to human population in reservoirs utilized for human supply—Southern Brazil
Abstract The knowledge concerning associations between chronic chemical exposure and many disorders with complex etiology involving gene–environment interactions is increasing, and new methods must be developed to improve water quality monitoring. The complexity of chemical mixtures in polluted aquatic environments makes the evaluation of toxic potential in those sites difficult, but the use of biomarkers and bioindicators has been recognized as a reliable tool to assess risk of exposure to biota and also the human population. In order to evaluate the use of fish and biomarkers to ... περισσότερα »
Enhanced photochemical decomposition of environmentally persistent perfluorooctanoate by coexisting ferric ion and oxalate
Abstract Perfluorooctanoic acid (PFOA), an environmentally persistent pollutant, was found to be quickly decomposed under 254 nm UV irradiation in the presence of ferric ion and oxalic acid. To understand the PFOA decomposition mechanism by this process, the effects of reaction atmosphere and concentrations of ferric ions and oxalic acids on PFOA decomposition were investigated, as well as decomposition intermediates. PFOA mainly decomposes via two pathways: (i) photochemical oxidation via Fe(III)-PFOA complexes and (ii) one-electron reduction caused by carboxylate anion radical (... περισσότερα »
Seasonal variability of mercury concentration in soils, buds and leaves of Acer platanoides and Tilia platyphyllos in central Poland
Abstract In this paper, we present the results of mercury concentration in soils, buds and leaves of maple (*Acer platanoides*—*Ap*) and linden (*Tilia platyphyllos*—*Tp*) collected in four periods of the growing season of trees, i.e. in April (IV), June (VI), August (VIII) and November (IX) in 2013, from the area of Poznań city (Poland). The highest average concentration of mercury for 88 samples was determined in soils and it equaled 65.8 ± 41.7 ng g−1 (range 14.5–238.9 ng g−1); lower average concentration was found in *Ap* samples (*n* = 66): 55.4 ± 18.1 ng g−1 (range 26.5–106.... περισσότερα »
Determination of the distribution and speciation of selenium in an argillaceous sample using chemical extractions and post-extractions analyses: application to the hydrogeological experimental site of Poitiers
Abstract To better understand selenium's dynamics in environmental systems, the present study aims to investigate selenium speciation and distribution in black argillaceous sediments, partially fulfilling karstic cavities into the Hydrogeological Experimental Site of Poitiers. These sediments are suspected to be responsible for selenium concentrations exceeding the European Framework Directive's drinking water limit value (10 μg L−1) in some specific wells. A combination of a sequential extractions scheme and single parallel extractions was thus applied on a representative argilla... περισσότερα »
Uncommon situation and presentation of chronic sclerosing sialadenitis
Publication date: April 2016 Source:International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): T. Adouly, C. Adnane, Y. Housni, S. Rouadi, R. Abada, M. Roubal, M. Mahtar Chronic sclerosing sialadenitis of the parotid gland is a very uncommon chronic inflammatory salivary gland disease. Clinically, it presents as a slow-growing painful. Histologically, it showed a chronic inflammation… Continue reading Uncommon situation and presentation of chronic sclerosing sialadenitis
Value of radiofrequency ablation in the management of retropharyngeal lymphatic malformation
Publication date: April 2016 Source:International Journal of Pediatric Otorhinolaryngology, Volume 83 Author(s): Quentin Lisan, Aude Villepelet, Marine Parodi, Eréa-Noël Garabedian, Marie Julie Blouin, Vincent Couloigner, Nicolas Leboulanger Lymphatic malformations are benign malformations frequently occurring in the head and neck. Retropharyngeal location is rare, can be life threating and its management is particularly challenging. Over a… Continue reading Value of radiofrequency ablation in the management of retropharyngeal lymphatic malformation
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis
Publication date: Available online 4 February 2016 Source:International Journal of Pediatric Otorhinolaryngology Author(s): Juliana Sato Hermann, Lily Yin Weckx, Jussimara Monteiro Nürmberger, Gildo Francisco Dos Santos Junior, Antonio Carlos Campos Pignatari, Shirley Shizue Nagata Pignatari ObjectiveTo evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of… Continue reading Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papil... περισσότερα »
Determinants of basic public health services provision by village doctors in China: using non-communicable diseases management as an example
Abstract Background To ensure equity and accessibility of public health care in rural areas, the Chinese central government has launched a series of policies to motivate village doctors to provide basic public health services. Using chronic disease management and prevention as an example, this study aims to identify factors associated with village doctors’ basic public… Continue reading Determinants of basic public health services provision by village doctors in China: using non-communicable diseases management as an example
Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study
Abstract Background Hepatic steatosis confers an increased risk of metabolic and cardiovascular disease and higher health services use. Associations of the single nucleotide polymorphisms (SNP) PNPLA3 rs738409 and TM6SF2 rs58542926 with hepatic steatosis have recently been established. This study investigates the association between rs738409 and rs58542926 with health services utilization in a general population. Methods… Continue reading Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study
Capturing patients’ needs in casemix: a systematic literature review on the value of adding functioning inform ation in reimbursement systems
Abstract Background Contemporary casemix systems for health services need to ensure that payment rates adequately account for actual resource consumption based on patients’ needs for services. It has been argued that functioning information, as one important determinant of health service provision and resource use, should be taken into account when developing casemix systems. However, there… Continue reading Capturing patients’ needs in casemix: a systematic literature review on the value of adding functioning inform ation in reimbursement systems
Rest after concussion to avoid ‘sustained brain damage’
Although concussion is considered a ‘mild’ brain injury, a new study shows that it can cause long-lasting neurological damage unless the appropriate amount of rest is taken. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1S4Gyz0 via IFTTT
Archegonous Cystic Odontoma Is Not Necessarily Primordial
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1R7gJNv via IFTTT
The Invisible Epidemic: Radiation and Rising Rates of Thyroid Cancer – CounterPunch
CounterPunch The Invisible Epidemic: Radiation and Rising Rates of Thyroid Cancer CounterPunch Since 1991 the annual number of newly documented cases of thyroid cancer in the United States has skyrocketed from 12,400 to 62,450. It’s now the seventh most common type of cancer. Relatively little attention is paid to the butterfly-shaped thyroid … from #Head… Continue reading The Invisible Epidemic: Radiation and Rising Rates of Thyroid Cancer – CounterPunch
Intravital microscopy of the lung: minimizing invasiveness
In vivo microscopy has recently become a gold standard in lung immunology studies involving small animals, largely benefiting from the democratization of multiphoton microscopy allowing for deep tissue imaging. This technology represents currently our only way of exploring the lungs and inferring what happens in human respiratory medicine. The interest of lung in vivo microscopy… Continue reading Intravital microscopy of the lung: minimizing invasiveness
Photostimulation by femtosecond laser triggers restorable fragmentation in single mitochondrion
Mitochondrial research is important to the study of ageing, apoptosis, and metabolic diseases. Over the years, mitochondria have been studied with stimulation by chemical agents in a global manner for basic and applied research. This approach lacks of precision and accuracy in terms of spatial and temporal resolution. Here we demonstrate a direct and well-defined… Continue reading Photostimulation by femtosecond laser triggers restorable fragmentation in single mitochondrion
Time and order of eruption of first functional teeth in the upper jaw of post-larval life of Sicyopterus japonicus (Gobiidiae: Sicydiinae) during cranial metamorphosis at the time of river recruitment
Publication date: Available online 4 February 2016 Source:Archives of Oral Biology Author(s): Noriyuki Sahara, Keita Moriyama, Midori Iida, Shun Watanabe ObjectiveThe present study was aimed at elucidating the time and order of eruption of first functional teeth in the upper jaw of post-larval life of Sicyopterus japonicus (S. japonicus) during cranial metamorphosis at the time… Continue reading Time and order of eruption of first functional teeth in the upper jaw of post-larval life of Sicyopterus japonicus (Gobiidiae: Sicydiinae) during cranial metamorphosis at the time of river r... περισσότερα »
Pre-existing CD19-independent GL7− Breg cells are expanded during inflammation and in mice with lupus-like disease
Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Xiaoqian Wang, Yinxiang Wei, He Xiao, Xiaoling Liu, Yu Zhang, Gencheng Han, Guojiang Chen, Chunmei Hou, Li Zhang, Ning Ma, Beifen Shen, Yan Li, Charles E. Egwuagu, Renxi Wang Interleukin 10 (IL-10)-producing regulatory B-cells (Bregs) suppress inflammatory responses that mediate autoimmune diseases. However, it is unknown… Continue reading Pre-existing CD19-independent GL7− Breg cells are expanded during inflammation and in mice with lupus-like disease
Trastuzumab use during pregnancy: long-term survival after locally advanced breast cancer and long-term infant follow-up.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Here, we describe the case of a patient diagnosed with locally advanced breast cancer 8 years ago. Her treatment course was neoadjuvant chemotherapy, followed by mastectomy and then adjuvant radiotherapy and trastuzumab (TTZ). During the use of adjuvant targeted therapy, an incidental pregnancy was diagnosed. Four years later, she developed bone and cerebral metastases, and […]
Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The objectives of this single-center, open-label, phase II study were to evaluate (a) the feasibility and safety of neoadjuvant administration of pemetrexed with oral folic acid and vitamin B12 (FA/B12) in newly diagnosed patients with resectable rectal cancer and (b) intracellular and systemic vitamin metabolism. Patients were treated with three cycles of pemetrexed (500 mg/m2, […]
Population pharmacokinetic/pharmacodynamic modeling of tumor growth kinetics in medullary thyroid cancer patients receiving cabozantinib.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nonlinear mixed effects models were developed to describe the relationship between cabozantinib exposure and target lesion tumor size in a phase III study of patients with progressive metastatic medullary thyroid cancer. These models used cabozantinib exposure estimates from a previously published population pharmacokinetic model for cabozantinib in cancer patients that was updated with data from […]
Miracle cells for natural dentistry – A review
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 4 February 2016 Source:Journal of Oral Biology and Craniofacial Research Author(s): Rani Somani, Shipra Jaidka, Neeti Bajaj, Sameksha Arora Stem cells are undifferentiated cells that can differentiate into specialized cells. Recently, enormous growth has been seen in the recognition of stem cell-based therapies, which have the potential to ameliorate the life […]
Melanome in der Schwangerschaft sind besonders gefährlich
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Mortalität fünffach erhöht Die Inzidenz von Melanomen nimmt bei Frauen zwischen dem 20. und 40. Lebensjahr rasch zu. Besonders riskant ist schwarzer Hauptkrebs, der während oder kurz nach einer Schwangerschaft auftritt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nLl0ud via IFTTT
Issue Information
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QhcLgH via IFTTT
The Cancer Experience: The Doctor, The Patient, The Journey. Roy B. Sessions. Rowman & Littlefield Publishers, Inc., Lanham, Maryland, 2012. No. of pages: 205. Price: $59.95 (US) ISBN: 978‐1442216211.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TIgppj via IFTTT
The effect of fixed appliances on oral malodor from beginning of treatment till 1 year
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Orthodontic appliances can enhance plaque accumulation, and this can cause gingival inflammation. Halitosis of oral origin is associated with microbial metabolism on the tongue and in the saliva, dental plaque, and the amount of volatile sulfide-containing compounds. This study used a Halimeter to investigate fixed orthodontic therapy-associated increases in the oral malodor over […]
Krüppel-like factor 4 expression in oral carcinoma cells and hypermethylation at the gene promoter
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Krüppel-like factor 4 (KLF4) is a transcription factor regulating proliferation-differentiation balance of epithelium, and down-regulated in less-differentiated and advanced oral carcinomas. Although the expression is inactivated by the promoter hypermethylation in malignant tumor cells, it remains unknown in oral carcinoma cells. Methods Genomic DNA isolated from nine different oral carcinoma cell lines and […]
IARC Meetings: Epigenetics and Environmental Origins of Cancer, 11-12 June 2016
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The International Agency for Research on Cancer (IARC) is pleased to announce a meeting on Epigenetics and Environmental Origins of Cancer, which will take place at IARC on 11-12 June 2016. The goals of this meeting are to evaluate recent scientific knowledge in the area, to determine future research needs, and to assess the implications […]
Assessing structural quality elements of pediatric emergency care
Pediatric Emergency Care from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20w9AfH via IFTTT
Assessment of tobacco smoke exposure in the pediatric emergency department
Preventive Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QheeU1 via IFTTT
Study assesses how avoidable acute admissions in hospitals could be avoided
Plymouth University News from Emergency Medicine via ola Kala on Inoreader http://ift.tt/20w9zZ6 via IFTTT
Increased expression of FGF1-mediated signaling molecules in adipose tissue of obese mice
Abstract Fibroblast growth factors (FGFs) are pleiotropic growth factors that control cell proliferation, migration, and differentiation. Herein, we evaluated whether visceral adiposity of mice is accompanied by the alteration of signaling molecules mediated by fibroblast growth factor receptor 1 (FGFR1) induced by using two different male C57BL/6J mice models of obesity namely high-fat diet (HFD)-induced obesity for 12 weeks or mice with genetic deletion of leptin (*ob/ob*). Both HFD-fed and *ob*/*ob* mice exhibited significantly higher messenger RNA (mRNA) levels of FGF1, cyclin ...περισσότερα »
A phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma
BMC Cancer from #Medicine via ola Kala on Inoreader http://ift.tt/20L4GZ0 via IFTTT
Gaining perspective on own illness – the lived experiences of a patient education programme for women with treated coeliac disease
Journal of Clinical Nursing from #Medicine via ola Kala on Inoreader http://ift.tt/1oc29sX via IFTTT
Daclatasvir and sofosbuvir versus sofosbuvir and ribavirin in patients with chronic hepatitis C coinfected with HIV: A matching-adjusted indirect comparison
Clinical Therapeutics from #Medicine via ola Kala on Inoreader http://ift.tt/20L4GIC via IFTTT
Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk
Cancer Epidemiology, Biomarkers & Prevention from #Medicine via ola Kala on Inoreader http://ift.tt/20L4E3q via IFTTT
Changes in speciation and leaching behaviors of heavy metals in dredged sediment solidified/stabilized with various materials
Abstract Solidification/stabilization (S/S) of sediments is frequently used to treat contaminants in dredged sediments. In this study, sediment collected from the Pearl River Delta (China) was solidified/stabilized with three different kinds of functional materials: cement, lime and bentonite. Lime primarily acted via induced increases in pH, while cements stabilization occurred through their silicate-based systems and the main function of bentonite was adsorption. The speciation and leaching behaviors of specific heavy metals before and after S/S were analyzed and the results show... περισσότερα »
Effects of pressure ulcer classification system education programme on knowledge and visual differential diagnostic ability of pressure ulcer classification and incontinence-associated dermatitis for clinical nurses in Korea
Abstract The objective of this study was to evaluate the effect of pressure ulcer classification system education on clinical nurses' knowledge and visual differential diagnostic ability of pressure ulcer (PU) classification and incontinence-associated dermatitis (IAD). One group pre and post-test was used. A convenience sample of 407 nurses, participating in PU classification education programme of continuing education, were enrolled. The education programme was composed of a 50-minute lecture on PU classification and case-studies. The PU Classification system and IAD knowledge t... περισσότερα »
A descriptive study of Korean nurses' perception of pain and skin tearing at dressing change
Abstract This study aimed to investigate Korean nurses' level of awareness of pain and skin tearing in wound bed and/or peri-wound skin at dressing change. A descriptive study was performed. Convenience sampling was employed and registered nurses were recruited from attendees of continuing education program. A total of 399 participants (RN) completed questionnaire. Data was collected from September to November 2014. Many of them perceived skin tearing and wound related pain associated with dressing changing, but most of them did not assess and record pain and skin tearing at dressi... περισσότερα »
The effect of diabetes on the wound healing potential of adipose-tissue derived stem cells
Abstract To investigate whether diabetes mellitus affects the wound-healing-promoting potential of adipose tissue-derived stem cells, we designed a wound-healing model using diabetic mice. We compared the degree of wound healing between wounds treated with normal adipose tissue-derived stem cells and wounds treated with diabetic adipose tissue-derived stem cells. We evaluated the wound-healing rate, the epithelial tongue distance, the area of granulation tissue, the number of capillary and the number of Ki-67-stained cells. The wound-healing rate was significantly higher in the no... περισσότερα »
Prospective study on Incontinence-Associated Dermatitis and its Severity instrument for verifying its ability to predict the development of pressure ulcers in patients with fecal incontinence
Abstract Fecal incontinence with loose stools is a risk factor for skin damage that may develop into a pressure ulcer (PU). The aim of this study was to determine the feasibility of applying the Incontinence-Associated Dermatitis and its Severity (IADS) instrument to patients with fecal incontinence as a tool to predict PU development. This prospective study enrolled 120 intensive care unit patients with bowel incontinence of Bristol Stool type 5, 6, and 7. Trained nurses evaluated IADS scores and the occurrence of PUs daily for 7 days. Patients with higher IADS scores were signif... περισσότερα »
Efficacy of one-stage surgical treatment and clinical features in patients with multiple pressure ulcers
Abstract Treating patients with multiple pressure ulcers is a very challenging task for physicians. However, there are very few reports on treatment protocols for multiple pressure ulcers and treatment outcomes. The authors have consistently treated multiple pressure ulcers in a one-stage operation rather than a staged operation. We evaluated multiple pressure ulcers patients who underwent a one-stage operation from 2007 to 2014. A comparison was made between 20 patients who underwent a one-stage operation on 44 foci and 68 patients with a single focus. Though the results, we coul... περισσότερα »
From competency to dormancy: a 3D model to study cancer cells and drug responsiveness
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The heterogeneous and dynamic tumor microenvironment has significant impact on cancer cell proliferation, invasion, drug response, and is probably associated with entering dormancy and recurrence. However, the… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QK7elz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The Antitumor Effect of DYC-279 on Human Hepatocellular Carcinoma HepG2 Cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
DYC-279 is a newly synthesized compound. In this study, we revealed that DYC-279 could inhibit the proliferation of HepG2 cells in a dose- and time-dependent manner using the CCK-8 test. FACS showed that DYC-279 induced a G2/M arrest and apoptosis in a dose-dependent manner. Western blot demonstrated that DYC-279-induced G2/M arrest effect was correlated with […]
Polyethylene glycol hydrogel rectal spacer implantation in patients with prostate cancer undergoing combination high-dose-rate brachytherapy and external beam radiotherapy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
To present rectal toxicity rates in patients administered a polyethylene glycol (PEG) hydrogel rectal spacer in conjunction with combination high-dose-rate brachytherapy and external beam radiotherapy. (Source: Brachytherapy) from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SwUr9L via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Nitrobenzoxadiazole derivatives (NBDs), including NBDHEX and the recently developed MC3181, are promising anticancer agents able to target glutathione transferase and inhibit both its catalytic activity and a… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SwUqCP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Kikuchi-Fujimoto Disease Associated With Subcutaneous Panniculitis-Like T-Cell Lymphoma.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a variant of cutaneous T-cell lymphoma that can mimic inflammatory panniculitis, particularly lupus erythematosus panniculitis, clinically and histologically. Patients with SPTL generally have a benign course, though SPTL can be complicated by hemophagocytic syndrome, which can negatively impact prognosis. We report a patient with recurrent SPTL and hemophagocytic syndrome […]
Hair Follicle Nevus With Features of Comedo Nevus: An Expanding Spectrum.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Hair follicle nevus (HFN) is a rare hamartomatous lesion of the folliculosebaceous unit, with or without admixed fibroadipose or muscular tissue. It typically has a congenital presentation in the preauricular area of infants and is frequently confused with an accessory tragus. Acquired tumors with similar histopathologic features have been described infrequently during adolescence and adult […]
Intralymphatic Proliferation of T-cell Lymphoid Blasts in the Setting of Hidradenitis Suppurativa.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Intralymphatic proliferation of T-cell lymphoid blasts (IPTCLBs) is a rare, recently described entity, associated with cutaneous inflammatory conditions and characterized by intralymphatic proliferation of highly proliferating, blastoid T lymphocytes expressing CD30, thus mimicking an intravascular lymphoma. In all reported cases, the intralymphatic proliferation was associated with an underlying inflammatory condition, with no clonal T-cell receptor […]
Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Follicular unit transplantation is the most commonly performed technique in modern restorative hair transplantation surgery. It relies on the acquisition of intact follicular units from microdissected scalp skin strips and their subsequent transplantation into the recipient regions affected by alopecia. Ideally, the translocation of follicular units from the balding-resistant areas of the scalp (usually the […]
Hemosiderotic Fibrolipomatous Tumor.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QK7dOx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Ulcerated Postirradiation Panniculitis After Cardiac Catheterization.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
No abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SwUoe4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Melanome in der Schwangerschaft sind besonders gefährlich
Mortalität fünffach erhöht Die Inzidenz von Melanomen nimmt bei Frauen zwischen dem 20. und 40. Lebensjahr rasch zu. Besonders riskant ist schwarzer Hauptkrebs, der während oder kurz nach einer Schwangerschaft auftritt. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nLl0ud via IFTTT
Toxins, Vol. 8, Pages 38: Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom
Lung cancer is one of the most common types of cancer in men and women and a leading cause of death worldwide resulting in more than one million deaths per year. The venom of marine snails Conus contains up to 200 pharmacologically active compounds that target several receptors in the cell membrane. Due to their… Continue reading Toxins, Vol. 8, Pages 38: Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom
Toxins, Vol. 8, Pages 39: A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target
A novel conotoxin, named as PiVIIA, was isolated from the venom of Conus princeps, a marine predatory cone snail collected in the Pacific Southern Coast of Mexico. Chymotryptic digest of the S-alkylated peptide in combination with liquid chromatography coupled to tandem mass spectrometry, were used to define the sequencing of this peptide. Eleven N-terminal amino… Continue reading Toxins, Vol. 8, Pages 39: A New Member of Gamma-Conotoxin Family Isolated from Conus princeps Displays a Novel Molecular Target
Automated tube voltage selection for radiation dose and contrast medium reduction at coronary CT angiography using 3 rd generation dual-source CT
Abstract Objectives To investigate the relationship between automated tube voltage selection (ATVS) and body mass index (BMI) and its effect on image quality and radiation dose of coronary CT angiography (CCTA). Methods We evaluated 272 patients who underwent CCTA with 3rd generation dual-source CT (DSCT). Prospectively ECG-triggered spiral acquisition was performed with automated tube current… Continue reading Automated tube voltage selection for radiation dose and contrast medium reduction at coronary CT angiography using 3 rd generation dual-source CT
PI-RADS version 2 for prediction of pathological downgrading after radical prostatectomy: a preliminary study in patients with biopsy-proven Gleason Score 7 (3+4) prostate cancer
Abstract Objectives To evaluate PI-RADSv2 for predicting pathological downgrading after radical prostatectomy (RP) in patients with biopsy-proven Gleason score (GS) 7(3+4) PC. Methods A total of 105 patients with biopsy-proven GS 7(3+4) PC who underwent multiparametric prostate MRI followed by RP were included. Two radiologists assigned PI-RADSv2 scores for each patient. Preoperative clinicopathological variables and… Continue reading PI-RADS version 2 for prediction of pathological downgrading after radical prostatectomy: a preliminary study in patients with biopsy-proven Gleason S... περισσότερα »
Gouty arthritis: the diagnostic and therapeutic impact of dual-energy CT
Abstract Objectives To determine the diagnostic and therapeutic impact of dual-energy computed tomography (DECT) in gout. Methods Forty-three patients with (n = 20) and without a history of gout (n = 23) showing non-specific soft tissue deposits underwent DECT after unrewarding arthrocentesis. Two blinded, independent readers evaluated DECT for the presence of urate crystals. Clinical diagnosis, clinically suspected urate… Continue reading Gouty arthritis: the diagnostic and therapeutic impact of dual-energy CT
Cardiac magnetic resonance findings predicting mortality in patients with pulmonary arterial hypertension: a systematic review and meta-analysis
Abstract Objectives To provide a comprehensive overview of all reported cardiac magnetic resonance (CMR) findings that predict clinical deterioration in pulmonary arterial hypertension (PAH). Methods MEDLINE and EMBASE electronic databases were systematically searched for longitudinal studies published by April 2015 that reported associations between CMR findings and adverse clinical outcome in PAH. Studies were appraised… Continue reading Cardiac magnetic resonance findings predicting mortality in patients with pulmonary arterial hypertension: a systematic review and meta-analysis
Journal of Otolaryngology – Head & Neck Surgery reviewer acknowledgement 2015
The Editors of Journal of Otolaryngology – Head & Neck Surgery would like to thank all our reviewers who have contributed their time and expertise to the journal in Volume 44 (2015). from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/23MY2nx via IFTTT
‘It’s been devastating’: former NFL players count the cost of concussion – The Guardian
The Guardian ‘It’s been devastating’: former NFL players count the cost of concussion The Guardian Doctors diagnosed cognitive impairment, chronic traumatic brain injury, frontal and temporal lobe disorders and generalized seizure disorder. Visger adds CTE to the list, but confirmation must await a postmortem. He qualified for California Workers … and more » from #Head… Continue reading ‘It’s been devastating’: former NFL players count the cost of concussion – The Guardian
Charles Darwin’s finches on the brink of extinction: Parasitic flies could wipe out the Galapagos Island birds in … – Daily Mail
Daily Mail Charles Darwin’s finches on the brink of extinction: Parasitic flies could wipe out the Galapagos Island birds in … Daily Mail Darwin’s finches, which inspired the naturalist’s revolutionary theory of evolution, are under threat from parasitic flies. Mathematical simulations have revealed the nest flies have the potential to drive populations of the most… Continue reading Charles Darwin’s finches on the brink of extinction: Parasitic flies could wipe out the Galapagos Island birds in … – Daily Mail
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