Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 λεπτό
Histological Spectrum of Angiofibroma of Soft Tissue: Histological and genetic analysis of 13 cases: Abstract Aims Angiofibroma of soft tissue (AFST) is a rare soft tissue neoplasm characterized by a fibroblastic cytomorphology and a prominent vascular structure. AFSTs possess a novel fusion gene NCOA2-AHRR/AHRR-NCOA2 or GTF2I-NCOA2, enabling a useful approach to diagnosing AFST. Morphologically, AFSTs cross a wide spectrum, making diagnosis a challenge. Thus we decided to review AFST cases and to report previously unknown histological features, which we confirmed by genetic analys... περισσότερα »
Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 λεπτό
Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach: [image: cover.gif?v=1&s=8da50c92b06d5da1183f2623] Abstract Aims Granular cell astrocytomas (GCAs) are morphologically characterized by a prominent component of granular PAS-positive cells and show an increased aggressiveness compared to “ordinary” astrocytomas. Here, we studied in a small series of three GCAs the expression of mesenchymal/radioresistance-associated biomarkers (such as YKL-40, c-Met and Cav1), which could contribute to the poor outcome of this gli... περισσότερα »
Scintigraphic Identification of Gastric Tissue in a Mediastinal Mass
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
ABSTRACT: We present a 99mTc pertechnetate scintigraphy performed in a 64-year-old woman to investigate a mediastinal cystic mass in search of residual gastric mucosa after gastrectomy. She had a history of esophagectomy and gastric pull-up for esophageal cancer. Postoperative leakage necessitated ablation of the gastric pull-up and reconstruction using part of the colon. Oral realimentation […]
Focally Increased FDG Activity in the Liver Related to Hydropic Degeneration
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: A 50-year-old man, who had diffuse large B-cell lymphoma in the neck and just finished 4 cycles of chemotherapy, presented to our department to evaluate the status of the disease. FDG PET/CT revealed a focally increased activity in the right lobe of the liver. However, pathological examination showed hepatocyte hydropic degeneration with associated inflammatory […]
MRI and FDG PET/CT Uncovered the Cause of a Paraneoplastic Leukemoid Reaction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: An 18-year-old man with progressive headache and vomiting for 2 weeks had significantly elevated levels of WBC count, which kept on rising over time during in-hospital evaluation. Exhaustive examinations did not reveal infection or any other explanations of increased WBC count. Instead, brain MRI and FDG PET/CT identified a malignant lesion in the brain […]
18F-FDG PET/CT in a Patient With Glomus Vagale Paraganglioma and Eisenmenger Syndrome: Searching for the Missing Link?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: There is emerging evidence linking cyanotic heart disease and pheochromocytoma-paraganglioma through a proposed hypoxia pathway. We present a 59-year-old woman with known Eisenmenger syndrome secondary to delayed diagnosis of ventricular septal defect, in whom 18F-FDG PET/CT provided comprehensive evaluation of both an 18F-FDG-avid left glomus vagale paraganglioma and also increased right ventricular myocardial glucose […]
18F-FDG Hypermetabolism in Spinal Cord Schistosomiasis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: A 24-year-old Saudi man presented with progressive lower-back pain for 3 months followed by lower-limb weakness, numbness, and urinary retention. Cerebrospinal fluid examination revealed high-protein, elevated white blood cell count with lymphocyte predominance. MRI scan of the spine demonstrated heterogeneously enhancing longitudinal spinal cord lesion from T6 through T9. 18FDG-PET/CT demonstrated prominently hypermetabolic lesion […]
A Case of a Man With Isolated Breast Metastasis From Lung Adenocarcinoma Incidentally Detected by FDG PET/CT
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: Breast metastases from an extramammary primary tumor are very rare, particularly in men. In this study, we present a case of a 74-year-old man with isolated breast metastasis from lung adenocarcinoma as an incidental finding on PET/CT and diagnosed concomitantly with the primary tumor. Detection of isolated incidental metastatic lesions in the breast on […]
Isolated Calcaneal Metastasis: An Unusual Presentation of Lung Carcinoma as Heel Pain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: A 63-year-old woman initially presented with progressive left foot pain for 3 months, not responding to conservative management. MRI of the left foot showed a suspicious lesion in calcaneus. An open biopsy was consistent with metastatic lung adenocarcinoma. 99mTc-MDP total-body bone scintigraphy was ordered for possible other bony lesions, and only left calcaneus lesion […]
“Cold” Spondylodiscitis on 18F-FDG PET/CT in a Patient With Myelofibrosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Abstract: A 74-year-old man was evaluated by bone scan for possible rib fractures, which revealed a diffuse skeletal uptake secondary to myelofibrosis and focal midthoracic uptake. Chest CT and 18F-FDG PET/CT demonstrated pathological vertebral fractures of the midthoracic spine, which appeared as a cold defect on PET comparing to intense marrow uptake related to myelofibrosis […]
Behavioral Pure-Tone Threshold Shifts Caused by Tympanic Membrane Electrodes.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
Objective: To determine whether tympanic membrane (TM) electrodes induce behavioral pure-tone threshold shifts. Design: Pure-tone thresholds (250 to 8000 Hz) were measured twice in test (n = 18) and control (n = 10) groups. TM electrodes were placed between first and second threshold measurements in the test group, whereas the control group did not receive […]
Association between small particle air pollution, climate and childhood eczema prevalence and severity: a US population‐based study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 λεπτό
ConclusionsPollutants in conjunction with climate factors may differentially impact eczema prevalence and severity, some with apparent harmful effects.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S4trha via IFTTT
Biomarkers in axial spondyloarthritis
An update on via Autoimmunity Reviews Publication date: Available online 4 February 2016 *Source:*Autoimmunity Reviews Author(s): Klára Prajzlerová, Kristýna Grobelná, Karel Pavelka, Ladislav Šenolt, Mária Filková Axial spondyloarthritis is a chronic inflammatory disease with the onset at a young age, and, if undiagnosed and untreated, it may result in permanent damage and lifelong disability. Rates of early diagnosis have improved, due in particular to the addition of magnetic resonance imaging into the diagnostic armamentaria; however, it is costly, not widely available, and requir... περισσότερα »
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online
These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Prevalence of malignancies in... περισσότερα »
Granulomatosis with polyangiitis (GPA),Anti-neutrophil cytoplasmic antibodies (ANCA) : Granulomatosis with polyangiitis and facial palsy
: Literature review and insight in the autoimmune pathogenesis via Autoimmunity Reviews Publication date: Available online 4 February 2016 *Source:*Autoimmunity Reviews Author(s): Giannicola Iannella, Antonio Greco, Guido Granata, Alessandra Manno, Benedetta Pasquariello, Diletta Angeletti, Dario Didona, Giuseppe Magliulo Granulomatosis with polyangiitis (GPA) is an autoimmune systemic necrotizing small-vessel vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Oto-neurological manifestations of ANCA associated vasculitis according to PR3-ANCA pos...περισσότερα »
Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155
Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155: AbstractT cell Ig and ITIM domain (TIGIT) is a newly identified inhibitory receptor expressed on T and natural killer (NK) cells. Cytokine-induced killer (CIK) cells express CD3 and CD56 molecules, and share functional properties with both NK and T cells. However, it remains unknown whether TIGIT is expressed in CIK cells. Here, we show that TIGIT is expressed by CIK cells and interacts with CD155. By blocking TIGIT using an anti-TIGIT functional antibody, we demonstrate... περισσότερα »
Lessons learned from cancer vaccine trials and target antigen choice
Lessons learned from cancer vaccine trials and target antigen choice: AbstractA wide variety of tumor antigens have been targeted in cancer immunotherapy studies. Traditionally, the focus has been on commonly overexpressed antigens shared across many patients and/or tumor types. As the field has progressed, the identity of human tumor rejection antigens has broadened. Immunologic monitoring of clinical trials has slowly elucidated candidate biomarkers of immune response and clinical response, and conversely, of immune dysfunction and suppression. We have utilized MART-1/Melan-A in ...περισσότερα »
The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity
The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity: AbstractMalignant transformations are often associated with aberrant glycosylation processes that lead to the expression of new carbohydrate antigens at the surface of tumor cells. Of these carbohydrate antigens, the Tn antigen is particularly highly expressed in many carcinomas, especially in breast carcinoma. We designed MAG-Tn3, a fully synthetic vaccine based on three consecutive Tn moieties that are *O*-linked to a CD4+ T cell epitope,... περισσότερα »
Worldwide trends in incidence in occupational allergy and asthma.
Worldwide trends in incidence in occupational allergy and asthma.: Purpose of review: Recent improvements in the methods for analyzing trends in occupational health surveillance and the prospect of future improvements in the collecting and sharing of electronic data alongside increasing availability of linked datasets make this a good time to review the existing literature on trends in occupational allergy and asthma (OAA). Recent findings: There is a notable lack of reports of recent trends in OAA in the academic literature and much of the published work comes from European countrie... περισσότερα »
Worldwide trends in incidence in occupational allergy and asthma.
Worldwide trends in incidence in occupational allergy and asthma.: Purpose of review: Recent improvements in the methods for analyzing trends in occupational health surveillance and the prospect of future improvements in the collecting and sharing of electronic data alongside increasing availability of linked datasets make this a good time to review the existing literature on trends in occupational allergy and asthma (OAA). Recent findings: There is a notable lack of reports of recent trends in OAA in the academic literature and much of the published work comes from European countrie... περισσότερα »
The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts
The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts: Abstract The relationship of cerebral vessel pathology to brain microinfarcts is not fully understood. We examined associations of cerebral vessel pathology with microinfarcts among community-dwelling persons who came to autopsy. Brain specimens were derived from 1,066 deceased subjects (mean age-at-death = 88 years, 65% women) participating in a cohort study of aging. Microinfarcts were classified by number, age, and location. Severity of vessel pathologies was graded semi-quantitatively. Almost a third of subje...περισσότερα »
Fatal Hyponatremic Encephalopathy as a Result of Child Abuse From Forced Exercise
Fatal Hyponatremic Encephalopathy as a Result of Child Abuse From Forced Exercise: Abstract: We report a case of fatal hyponatremic encephalopathy in a child who was forced to exercise as a form of punishment. A 9-year-old girl with attention-deficit/hyperactivity disorder was forced to run repeated 50-ft sprints to the point of exhaustion by her grandmother as punishment for taking candy from a classmate. After more than 3 hours of forced running, the child collapsed, began to vomit, and had repeated clonic seizures. Upon presentation to the emergency department, she was nonrespons...περισσότερα »
Postmortem Propofol Levels: A Case of Residual Detection Long After Administration
Postmortem Propofol Levels: A Case of Residual Detection Long After Administration: [image: image]Abstract: Propofol has gained notoriety in recent years because of its involvement in high-profile deaths and has increasingly become a drug of misuse and abuse particularly by health care personnel with easy access to it. In addition, propofol has also been used for more nefarious purposes such as murder and suicide. These, coupled with the drug’s routine use for both major and minor medical procedures, provide ample opportunities for it to be implicated as a cause of death or contribu... περισσότερα »
The styloauricular muscle: clinical relevance and literature review of this rare muscle
The styloauricular muscle: clinical relevance and literature review of this rare muscle: Abstract PurposeIn humans, the styloauricularis is a rare muscle extending from the tragal cartilage of the auricle to the styloid process. When it contracts, by bearing on the styloid process, it increases the cephalo-auricular angle. It can be a landmark for the facial nerve. We report a case with bilateral presence of the styloauricularis. MethodsBilateral presence of the styloauricularis was discovered during routine dissection of the head and neck. ResultsIn the presented case, sty... περισσότερα »
Direct Acoustical Cochlea Stimulation in Comparison to Cochlear Implants
Indication of via Hearing Research Publication date: Available online 4 February 2016 *Source:*Hearing Research Author(s): Eugen Kludt, Andreas Büchner, Burkard Schwab, Thomas Lenarz, Hannes Maier The new implantable hearing system Codacs™ was designed to close the treatment gap between active middle ear implants and cochlear implants in cases of severe-to-profound mixed hearing loss. The Codacs™ actuator is attached to conventional stapes prosthesis during the implantation and thereby provides acoustical stimulation through a stapedotomy to the cochlea. Cochlear implants (CIs) on th... περισσότερα »
Multimodal acquisition of articulatory data: Geometrical and temporal registration
Multimodal acquisition of articulatory data: Geometrical and temporal registration: Acquisition of dynamic articulatory data is of major importance for studying speech production. It turns out that one technique alone often is not enough to get a correct coverage of the whole vocal tract at a sufficient sampling rate. Ultrasound(US)imaging has been proposed as a good acquisition technique for the tongue surface because it offers a good temporal sampling, does not alter speech production, is cheap, and is widely available. However, it cannot be used alone and this paper describes a... περισσότερα »
Fast evaluation of transient acoustic fields
Fast evaluation of transient acoustic fields: The efficient computation of transient fields radiated by non-harmonic source distributions is a problem relevant in numerous areas of acoustics. This paper presents an efficient easily implemented method for the generation of time-dependent spherical harmonic expansions for arbitrary sources, which can be used to compute the transient radiated field at arbitrary points outside the source domain. The method depends on the theory of time-domain spherical harmonic expansions and the solution of Vandermonde systems. Results are presented d...περισσότερα »
K+ Channels in Vestibular Hair Cells
Channeling Your Inner Ear Potassium: K+ Channels in Vestibular Hair Cells via Hearing Research Publication date: Available online 4 February 2016 *Source:*Hearing Research Author(s): Frances L. Meredith, Katherine J. Rennie During development of vestibular hair cells, K+ conductances are acquired in a specific pattern. Functionally mature vestibular hair cells express different complements of K+ channels which uniquely shape the hair cell receptor potential and filtering properties. In amniote species, type I hair cells (HCI) have a large input conductance due to a ubiquitous low–volta...περισσότερα »
Summary of the N1-P2 Cortical Auditory Evoked Potential to Estimate the Auditory Threshold in Adults
Summary of the N1-P2 Cortical Auditory Evoked Potential to Estimate the Auditory Threshold in Adults: Semin Hear 2016; 37: 001-008 DOI: 10.1055/s-0035-1570334 This article introduces the cortical auditory evoked potential (CAEP) and describes the use of the N1-P2 response complex as an objective predictor of hearing threshold in adults and older children. The generators of the CAEP are discussed together with issues of maturation, subject factors, and stimuli and recording parameters for use in the clinic. The basic methods for response identification are outlined and suggestions a...περισσότερα »
The Effect of Short-Term Auditory Training on Speech in Noise Perception and Cortical Auditory Evoked Potentials in Adults with Cochlear Implants
The Effect of Short-Term Auditory Training on Speech in Noise Perception and Cortical Auditory Evoked Potentials in Adults with Cochlear Implants: Semin Hear 2016; 37: 084-098 DOI: 10.1055/s-0035-1570335 This study investigated whether a short intensive psychophysical auditory training program is associated with speech perception benefits and changes in cortical auditory evoked potentials (CAEPs) in adult cochlear implant (CI) users. Ten adult implant recipients trained approximately 7 hours on psychophysical tasks (Gap-in-Noise Detection, Frequency Discrimination, Spectral Rippled...περισσότερα »
DHEA improves the antioxidant capacity of endometrial stromal cells and improves endometrium receptivity via androgen receptor.
Related Articles *DHEA improves the antioxidant capacity of endometrial stromal cells and improves endometrium receptivity via androgen receptor.* Eur J Obstet Gynecol Reprod Biol. 2016 Jan 15;198:120-126 Authors: Qin A, Qin J, Jin Y, Xie W, Fan L, Jiang L, Mo F Abstract OBJECTIVE: To investigate the effect of dehydroepiandrosterone (DHEA) on mouse decidual endometrial stromal cells (ESCs) and to explore mechanisms regulating endometrial receptivity. STUDY DESIGN: Mouse ESCs were incubated with increasing concentrations of DHEA during decidualization. Treatment with flutamide (FLU... περισσότερα »
A phase 1 randomized, double-blind, placebo-controlled, crossover trial of DAS181 (Fludase®) in adult subjects with well-controlled asthma.
Related Articles *A phase 1 randomized, double-blind, placebo-controlled, crossover trial of DAS181 (Fludase®) in adult subjects with well-controlled asthma.* BMC Infect Dis. 2016;16(1):54 Authors: Colombo RE, Fiorentino C, Dodd LE, Hunsberger S, Haney C, Barrett K, Nabha L, Davey RT, Olivier KN Abstract BACKGROUND: Influenza virus (IFV) infection is associated with increased morbidity and mortality in people with underlying lung disease. Treatment options for IFV are currently limited and antiviral resistance is a growing concern. DAS181, an inhaled antiviral with a unique mecha...περισσότερα »
Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults.* Mol Nutr Food Res. 2016 Jan 28; Authors: Meng H, Lee Y, Ba Z, Peng J, Lin J, Boyer AS, Fleming JA, Furumoto EJ, Roberts RF, Kris-Etherton PM, Rogers CJ Abstract SCOPE: Probiotics can modulate immunity and reduce upper respiratory tract infections (URTI) in humans; however few studies have examined both outcom...περισσότερα »
Correlation of Clinicohaematological Parameters in Paediatric Dengue: A Retrospective Study.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Correlation of Clinicohaematological Parameters in Paediatric Dengue: A Retrospective Study.* J Trop Med. 2015;2015:647162 Authors: Pai Jakribettu R, Boloor R, Thaliath A, Yesudasan George S, George T, Ponadka Rai M, Rafique Sheikh U, Avabratha KS, Baliga MS Abstract Dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquito Aedes aegypti. Dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mo...περισσότερα »
Efficacy and safety of recombinant human tumor necrosis factor application for the treatment of malignant pleural effusion caused by lung cancer.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Efficacy and safety of recombinant human tumor necrosis factor application for the treatment of malignant pleural effusion caused by lung cancer.* Thorac Cancer. 2016 Jan;7(1):136-9 Authors: Li Q, Sun W, Yuan D, Lv T, Yin J, Cao E, Xiao X, Song Y Abstract Malignant pleural effusion (MPE) signifies a poor prognosis for patients with lung cancer. For treating physicians, the primary goals are to achieve sufficient control of MPE and minimize invasive intervention. Recombinant human mutant tumor necrosis factor-alpha (rhu-TNF) h...περισσότερα »
Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens.* Vaccine. 2016 Jan 20; Authors: Dixit R, Herz J, Dalton R, Booy R Abstract BACKGROUND: Passive immunotherapy using polyclonal antibodies (immunoglobulins) has been used for over a century in the treatment and post-exposure prophylaxis of various infections and toxins. Heterologous polyclonal antibodies are obtained from animals hyperimmunised with a pathogen or toxin. AIMS: The aims of thi... περισσότερα »
H7N9 Live attenuated influenza vaccine is highly immunogenic, prevents virus replication and protects against severe bronchopneumonia in ferrets.
[image: http:--http://ift.tt/1feGv2I] Related Articles *H7N9 Live attenuated influenza vaccine is highly immunogenic, prevents virus replication and protects against severe bronchopneumonia in ferrets.* Mol Ther. 2016 Jan 22; Authors: de Jonge J, Isakova-Sivak I, van Dijken H, Spijkers S, Mouthaan J, de Jong R, Smolonogina T, Roholl P, Rudenko L Abstract Avian influenza viruses continue to cross the species barrier and may such a virus become transmissible among humans this would pose a great threat to public health. H7N9 emerged in China in 2013 and has since caused considerable...περισσότερα »
Histopathological findings in a critically ill patient with avian influenza A (H7N9).
[image: http:--http://ift.tt/20dzOOw] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Histopathological findings in a critically ill patient with avian influenza A (H7N9).* J Thorac Dis. 2015 Dec;7(12):E672-7 Authors: Huang JB, Li HY, Liu JF, Lan CQ, Lin QH, Chen SX, Zhang HY, Wang XH, Lin X, Pan JG, Weng H Abstract To date, data regarding the pulmonary histopathology of human H7N9 disease are scarce. We herein describe a patient with a severe case of avian influenza A (H7N9). A chest computerized tomography (CT) scan showed diffuse ground-glass opacities and consolidati... περισσότερα »
Antifungal Activity of Propolis Against Yeasts Isolated From Blood Culture: In Vitro Evaluation.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Antifungal Activity of Propolis Against Yeasts Isolated From Blood Culture: In Vitro Evaluation.* J Clin Lab Anal. 2016 Jan 20; Authors: Mutlu Sariguzel F, Berk E, Koc AN, Sav H, Demir G Abstract BACKGROUND: Due to the failure of available antifungal agents in the treatment of candidemia and the toxic activities of these drugs, a lot of researches are being conducted to develop new nontoxic and effective antifungal agents for optimal control of fungal pathogens. T... περισσότερα »
Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.* Immunity. 2016 Jan 19;44(1):46-58 Authors: Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs DH, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LC, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I Abstract Viruses are obligate ...περισσότερα »
Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients.
[image: http:--http://ift.tt/1II1iHB] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients.* PLoS One. 2016;11(1):e0146620 Authors: Soto M, Sampietro-Colom L, Vilella A, Pantoja E, Asenjo M, Arjona R, Hurtado JC, Trilla A, Alvarez-Martínez MJ, Mira A, Vila J, Marcos MA Abstract Seasonal influenza causes significant morbidity and mortality and has a substantial economic impact on the healthcare system. The main objective of this study was to compare the co...περισσότερα »
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.
Related Articles *The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.* Antimicrob Agents Chemother. 2016 Jan 19; Authors: Baranovich T, Jones JC, Russier M, Vogel P, Szretter KJ, Sloan SE, Seiler P, Trevejo JM, Webby RJ, Govorkova EA Abstract Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting ...περισσότερα »
Virus-inhibiting activity of dihydroquercetin, a flavonoid from Larix sibirica, against coxsackievirus B4 in a model of viral pancreatitis.
[image: http:--production.springer.de-OnlineReso] Related Articles *Virus-inhibiting activity of dihydroquercetin, a flavonoid from Larix sibirica, against coxsackievirus B4 in a model of viral pancreatitis.* Arch Virol. 2016 Jan 18; Authors: Galochkina AV, Anikin VB, Babkin VA, Ostrouhova LA, Zarubaev VV Abstract Members of the family Picornaviridae, in particular, enteroviruses, represent a serious threat to human health. They are responsible for numerous pathologies ranging from mild disease to fatal outcome. Due to the limited number of safe and effective antivirals against en... περισσότερα »
Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.* Transfus Clin Biol. 2016 Jan 6; Authors: Garraud O, Heshmati F, Pozzetto B, Lefrere F, Girot R, Saillol A, Laperche S Abstract Plasma therapy consists in bringing to a patient in need - in general suffering a severe, resistant to current therapy, and even lethal infection - plasma or specific, fractioned, antibodies, along with other immunoglobulins and possibly healing factors that can be obtained from immunized blood donors; don... περισσότερα »
Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance.
[image: http:--http://ift.tt/1gvJT9Y] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Discovery of Influenza A Virus Sequence Pairs and Their Combinations for Simultaneous Heterosubtypic Targeting that Hedge against Antiviral Resistance.* PLoS Comput Biol. 2016 Jan;12(1):e1004663 Authors: Wee KB, Lee RT, Lin J, Pramono ZA, Maurer-Stroh S Abstract The multiple circulating human influenza A virus subtypes coupled with the perpetual genomic mutations and segment reassortment events challenge the development of effective therapeutics. The capacity to drug most RNAs motivates... περισσότερα »
In vitro activity of Caspofungin combined with Fluconazole on mixed Candida albicans and Candida glabrata biofilm.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *In vitro activity of Caspofungin combined with Fluconazole on mixed Candida albicans and Candida glabrata biofilm.* Med Mycol. 2016 Jan 14; Authors: Pesee S, Angkananuwat C, Tancharoensukjit S, Muanmai S, Sirivan P, Bubphawas M, Tanarerkchai N Abstract The objective of this study was to evaluate the antifungal effect of caspofungin (CAS) combined with fluconazole (FLU) on the biofilm biomass and cultivable viability and microstructure of Candida albicans and Candida glabrata mixed biofilm in vitro. Biofilms were ... περισσότερα »
Influenza in the Emergency Department: Vaccination, Diagnosis, and Treatment: Clinical Practice Paper Approved by American Academy of Emergency Medicine Clinical Guidelines Committee.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Influenza in the Emergency Department: Vaccination, Diagnosis, and Treatment: Clinical Practice Paper Approved by American Academy of Emergency Medicine Clinical Guidelines Committee.* J Emerg Med. 2016 Jan 4; Authors: Abraham MK, Perkins J, Vilke GM, Coyne CJ Abstract BACKGROUND: Influenza is an acute respiratory virus that results in significant worldwide morbidity and mortality each year. As emergency physicians, we are often the first to encounter patients with seasonal influenza. It is therefore critical tha... περισσότερα »
[Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Outcomes of allogeneic hematopoietic stem cell transplantation for 18 patients with paroxysmal nocturnal haemoglobinuria].* Zhonghua Xue Ye Xue Za Zhi. 2015 Dec 14;36(12):1005-10 Authors: Chen F, Wu D, Tang X, Miao M, Fu C, Qiu H, Jin Z, Xue S, Ma X, Sun A, Chang W, Ruan C Abstract OBJECTIVE: To evaluate the outcomes of allogeneic hematopoietic stem cell transplantation（allo-HSCT）for paroxysmal nocturnal haemoglobinuria（PNH）and aplastic anemia（AA）- PNH syndrome. METHODS: The clinical data of 18 PNH or AA-PNH pati... περισσότερα »
[Treatment of Gaucher disease with allogeneic hematopoietic stem cell transplantation: report of three cases and review of literatures].
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Related Articles *[Treatment of Gaucher disease with allogeneic hematopoietic stem cell transplantation: report of three cases and review of literatures].* Zhonghua Er Ke Za Zhi. 2015 Nov;53(11):810-6 Authors: Tang X, Luan Z, Wu N, Zhang B, Jing Y, Du H, Lu W, Xu S Abstract OBJECTIVE: To explore the efficacy of unrelated umbilical cord blood transplantation (UCBT) in the treatment of Gaucher disease. METHOD: The clinical characteristics of three children with Gaucher disease underwent UCBT in our hospital between April 2013 and Sept...περισσότερα »
[Ebola: characterization, history and cutaneous manifestations].
[image: http:--http://ift.tt/1R8xNmj] Related Articles *[Ebola: characterization, history and cutaneous manifestations].* Rev Med Chil. 2015 Nov;143(11):1444-8 Authors: Kolbach M, Carrasco-Zuber JE, Vial-Letelier V Abstract Ebola virus (EV) is one of the most virulent human pathogens. Fruits bats are its natural reservoir, the transmission to humans is across wild animals (especially primates) and the propagation in human populations is through bodily fluid contact. The actual outbreak started in December 2013 and crossed continental borders. Up to now, there are 17,145 suspected ... περισσότερα »
Behavioral Pure-Tone Threshold Shifts Caused by Tympanic Membrane Electrodes.
Behavioral Pure-Tone Threshold Shifts Caused by Tympanic Membrane Electrodes.: Objective: To determine whether tympanic membrane (TM) electrodes induce behavioral pure-tone threshold shifts. Design: Pure-tone thresholds (250 to 8000 Hz) were measured twice in test (n = 18) and control (n = 10) groups. TM electrodes were placed between first and second threshold measurements in the test group, whereas the control group did not receive electrodes. Pure-tone threshold shifts were compared between groups. The effect of TM electrode contact location on threshold shifts was evaluated in th...περισσότερα »
Atmosphere, Vol. 7, Pages 23: The Application of TAPM for Site Specific Wind Energy Forecasting
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
The energy industry uses weather forecasts for determining future electricity demand variations due to the impact of weather, e.g., temperature and precipitation. However, as a greater component of electricity generation comes from intermittent renewable sources such as wind and solar, weather forecasting techniques need to now also focus on predicting renewable energy supply, which means adapting our prediction models to these site specific resources. This work assesses the performance of The Air Pollution Model (TAPM), and demonstrates that significant improvements can be made t...περισσότερα »
Catalysts, Vol. 6, Pages 25: Improved Low-Temperature Activity of V2O5-WO3/TiO2 for Denitration Using Different Vanadium Precursors
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
This work tested two V2O5-WO3/TiO2 catalysts with different vanadium precursors for selective catalytic reduction (SCR) of flue gas NO using NH3 at 150–450 °C. While catalyst A was prepared using ammonium metavanadate (NH4VO3) through incipient impregnation, catalyst B was made according to the solvothermal method using vanadyl acetylacetonate (VO(acac)2) as the vanadium precursor. The catalytic evaluation for denitration was in a laboratory fixed bed reactor using simulated flue gas under conditions of a gas hourly space velocity (GHSV) of 40,000 h−1 and an NH3/NO molar ratio of ...περισσότερα »
Aerospace, Vol. 3, Pages 6: Turbulence Effects on Modified State Observer-Based Adaptive Control: Black Kite Micro Aerial Vehicle
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
This paper presents the implementation of a modified state observer-based adaptive dynamic inverse controller for the Black Kite micro aerial vehicle. The pitch and velocity adaptations are computed by the modified state observer in the presence of turbulence to simulate atmospheric conditions. This state observer uses the estimation error to generate the adaptations and, hence, is more robust than model reference adaptive controllers which use modeling or tracking error. In prior work, a traditional proportional-integral-derivative control law was tested in simulation for its ada... περισσότερα »
Worldwide trends in incidence in occupational allergy and asthma.
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Purpose of review: Recent improvements in the methods for analyzing trends in occupational health surveillance and the prospect of future improvements in the collecting and sharing of electronic data alongside increasing availability of linked datasets make this a good time to review the existing literature on trends in occupational allergy and asthma (OAA). Recent findings: […]
Lesion of the Otic Capsule
An Uncommon Lesion of the Otic Capsule: A man in his 40s presented with a gradual-onset, left-sided hearing loss with a whistling tinnitus and occasional sharp otalgia; examination showed a smooth mass behind the left tympanic membrane. What is your diagnosis? [image: First page PDF preview]
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Gonadal hormones rapidly enhance spatial memory and increase hippocampal spine density in male rats Luis F. Jacome, et al. | Endocrinology | Feb 4, 2016 --------------------... περισσότερα »
IDO in the Tumor Microenvironment: Inflammation, Counter-regulation, and Tolerance.
Authors: Munn DH, Mellor AL Abstract Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell activation, either spontaneous or due to immunotherapy. Here we… Continue reading IDO in the Tumor Microenvironment: Inflammation, Counter-regulation, and Tolerance.
Can Social Cognitive Theories Help Us Understand Nurses’ Use of Electronic Health Records?.
Electronic health record implementations have accelerated in clinical settings around the world in an effort to improve patient safety and enhance efficiencies related to care delivery. As the largest group of healthcare professionals globally, nurses play an important role in the use of these records and ensuring their benefits are realized. Social cognitive theories such… Continue reading Can Social Cognitive Theories Help Us Understand Nurses’ Use of Electronic Health Records?.
Disorganisation of the splenic microanatomy in ageing mice.
This article is protected by copyright. All rights reserved. PMID: 26840375 [PubMed – as supplied by publisher] (Source: Immunology) from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1X7t9pd via IFTTT
Should We All Go Gluten-Free? Should We All Go Gluten-Free?
It is undoubtedly the major dietary trend of the decade, but is there evidence to support avoiding gluten if you don’t have celiac disease? Medscape Gastroenterology (Source: Medscape Allergy Headlines) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via… Continue reading Should We All Go Gluten-Free? Should We All Go Gluten-Free?
When a Cancer Dx Is Missed by Another Specialist
(MedPage Today) — It’s often not from lack of trying or lack of thought (Source: MedPage Today Allergy) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nR9SfZ via IFTTT
Otitis Media: New Guideline Includes Screening At-Risk KidsOtitis Media: New Guideline Includes Screening At-Risk Kids
Medical therapies should not be used, including antibiotics and nasal steroid sprays, according to updated American Academy of Otolaryngology-Head and Neck Surgery Foundation guidelines. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nL9YFk via IFTTT
New Drug Shows Promise Against Severe Sinusitis
Title: New Drug Shows Promise Against Severe SinusitisCategory: Health NewsCreated: 2/3/2016 12:00:00 AMLast Editorial Review: 2/4/2016 12:00:00 AM (Source: MedicineNet Allergies General) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nR9RZI via IFTTT
Genetic cause of rare allergy to vibration discovered
Scientists have identified a genetic mutation responsible for a rare form of inherited hives induced by vibration, also known as vibratory urticaria. Running, hand clapping, towel drying or even taking a bumpy bus ride can cause temporary skin rashes in people with this rare disorder. By studying affected families, researchers discovered how vibration promotes the… Continue reading Genetic cause of rare allergy to vibration discovered
Purified cashew proteins lend insight into allergic reactions
It’s well known that peanuts can cause severe reactions in people who are allergic, but research suggests that the risk of developing a life-threatening reaction could be higher for those allergic to cashews. Now scientists have come up with a fast and simple method to purify the three main cashew allergens to help better grasp… Continue reading Purified cashew proteins lend insight into allergic reactions
Self-reported penicillin allergy could be chronic hives
Brooks HaysPHILADELPHIA, Feb. 3 (UPI) — Researchers suspect the sizable overlap of patients who experience chronic hives and have a self-reported penicillin allergy is more than just a coincidence. (Source: Health News – UPI.com) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nL9VcH via IFTTT
3D-Visualisierung und Analyse von Stimmlippenschwingungen
Zusammenfassung Hintergrund Heutige visuelle Untersuchungsmethoden des Kehlkopfes und der Stimmlippenbewegung erlauben vorwiegend eine zweidimensionale Darstellung der real dreidimensionalen Strukturen und Bewegungen. Die vertikale Bewegungskomponente der Stimmlippen wird meist vernachlässigt, was zu einem Informationsverlust führt. Neuere Studien zeigen, dass die vertikale Komponente in einer ähnlichen Größenordnung wie die laterale Komponente liegt und einen nicht unerheblichen Anteil… Continue reading 3D-Visualisierung und Analyse von Stimmlippenschwingungen
Microbiota, Immunity and the Liver.
Authors: Vaikunthanathan T, Safinia N, Lombardi G, Lechler RI Abstract The gut harbors a complex community of over 100 trillion microbial cells known to exist in symbiotic harmony with the host influencing human physiology, metabolism, nutrition and immune function. It is now widely accepted that perturbations of this close partnership results in the pathogenesis of… Continue reading Microbiota, Immunity and the Liver.
The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency – a Dutch Pediatric Cohort Study
Conclusions This is the first Western-European mainly non-tertiary cohort of children with IgG-subclass deficiency and/or SPAD. The disease course is not always benign, especially in boys. Most children were reported and managed in secondary hospitals with a pediatric immunologist in the staff. To identify more patients, the awareness of these diseases among general pediatricians should… Continue reading The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency – a Dutch Pediatric Cohort Study
Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome
Our study investigated the frequency of interleukin-6 (IL-6) promoter polymorphism rs1800795 (−174 G>C), possible association of this polymorphism with IL-6 levels and the outcome after stroke in 95 patients with acute ischemic stroke and 268 healthy subjects. It shows a significant reduction in the frequency of G alleles in stroke patients compared to healthy controls.… Continue reading Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome
Erratum to: Regional brain dysregulation of Ca2+-handling systems in ketamine-induced rat model of experimental psychosis
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PWl7tt via IFTTT
Sox2 contributes to tooth development via Wnt signaling
Abstract The transcription factor Sox2 is a stem cell marker that dictates cell lineage. It has been shown to mark the epithelial stem cells of the continuously growing mouse incisors. Sox2 also interferes with Wnt signaling by binding to β-catenin, a central mediator of the Wnt pathway. We show that these functions of Sox2 are… Continue reading Sox2 contributes to tooth development via Wnt signaling
Anti-GAPDHS antibodies: a biomarker of immune infertility
Abstract Numerous investigations have focused on the detection of antisperm antibodies, which have a naturally occurring impact on male and female fertility. In this study, spermatogenic glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) was considered to be a candidate biomarker of immune infertility. The concentrations of anti–GAPDHS antibodies in the sera of sterile individuals and fertile couples were measured… Continue reading Anti-GAPDHS antibodies: a biomarker of immune infertility
Should We All Go Gluten-Free? Should We All Go Gluten-Free?
It is undoubtedly the major dietary trend of the decade, but is there evidence to support avoiding gluten if you don’t have celiac disease? Medscape Gastroenterology (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Pat0OW via IFTTT
Otitis Media: New Guideline Includes Screening At-Risk KidsOtitis Media: New Guideline Includes Screening At-Risk Kids
Medical therapies should not be used, including antibiotics and nasal steroid sprays, according to updated American Academy of Otolaryngology-Head and Neck Surgery Foundation guidelines. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1S4rtgK via IFTTT
Purification of infective bluetongue virus particles by immuno-affinity chromatography using anti-core antibody
Abstract An immuno-affinity chromatography technique for purification of infective bluetongue virus (BTV) has been descried using anti-core antibodies. BTV anti-core antibodies (prepared in guinea pig) were mixed with cell culture-grown BTV-1 and then the mixture was added to the cyanogens bromide-activated protein-A Sepharose column. Protein A binds to the antibody which in turn binds to… Continue reading Purification of infective bluetongue virus particles by immuno-affinity chromatography using anti-core antibody
Promoting Physical Activity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Facilitating healthy levels of physical activity (PA) during chemotherapy is important for the psychosocial and physical health of breast cancer survivors. The primary objective of this feasibility study was to examine the effects of a broad-reach PA behavior change intervention among women with breast cancer receiving adjuvant chemotherapy. Methods: Breast cancer patients receiving adjuvant […]
Arsenic Metabolism Phenotypes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Exposure to inorganic arsenic (iAs), a class I carcinogen, affects several hundred million people worldwide. Once absorbed, iAs is converted to monomethylated (MMA) and then dimethylated forms (DMA), with methylation facilitating urinary excretion. The abundance of each species in urine relative to their sum (iAs%, MMA%, and DMA%) varies across individuals, reflecting differences in […]
Circulating DNA and Survival in Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict clinical outcomes. Methods: A systematic review […]
Family History of Cancer and Risk of Breast Cancer Subtypes
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: The evidence on the relation of family history of cancers other than breast cancer to breast cancer risk is conflicting, and most studies have not assessed specific breast cancer subtypes. Methods: We assessed the relation of first-degree family history of breast, prostate, lung, colorectal, ovarian, and cervical cancer and lymphoma or leukemia, to the […]
Cerebral tissue oxygen saturation values in volunteers and patients in the lateral decubitus and beach chair positions: a prospective observational study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background The objective of this study was to describe changes in cerebral tissue oxygen saturation (SctO2) due to changes in body position in healthy volunteers and in patients undergoing surgery under general anesthesia in the beach chair position (BCP) and lateral decubitus position (LDP). Methods In this prospective observational study, SctO2 was measured in […]
Frequency and characteristics of healthcare visits associated with chronic pain: results from a population-based Canadian study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose This study was designed to investigate the role of chronic pain in healthcare visits. The specific objectives were to document the frequency of healthcare visits and to identify characteristics associated with frequent visits. Methods This is a secondary analysis of data from a Canadian cross-sectional study on chronic pain. One thousand two hundred […]
CRE bacteria: What you should know
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23MMQHy via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Polypöse Strukturen im Bulbus duodeni
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Schleimhautveränderungen Ein 24-Jähriger klagt über diffuse Magenbeschwerden. Unabhängig von der Mahlzeit verspüre er einen manchmal über Stunden anhaltenden Druck in der Magengegend. Der Appetit sei gut, der Stuhlgang unauffällig. Gewicht hat er nicht verloren. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23MMQHs via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
BMC Immunology reviewer acknowledgement, 2015
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Contributing reviewers The editors of BMC Immunology would like to thank all our reviewers who have contributed their time to the journal in Volume 16 (2015). from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VTasEE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background In Canada, 4,400 cases of oral cancer are diagnosed yearly. Surgical resection is a key component of treatment in many of these cancers. Reconstruction of defects, with the goal of preserving function, is of utmost importance. Several choices are possible for reconstruction of larger defects, including both free and pedicled flaps. Free flap […]
The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity
Abstract Malignant transformations are often associated with aberrant glycosylation processes that lead to the expression of new carbohydrate antigens at the surface of tumor cells. Of these carbohydrate antigens, the Tn antigen is particularly highly expressed in many carcinomas, especially in breast carcinoma. We designed MAG-Tn3, a fully synthetic vaccine based on three consecutive Tn moieties that are *O*-linked to a CD4+ T cell epitope, to induce anti-Tn antibody responses that could be helpful for therapeutic vaccination against cancer. To ensure broad coverage within the hum... περισσότερα »
Lessons learned from cancer vaccine trials and target antigen choice
Abstract A wide variety of tumor antigens have been targeted in cancer immunotherapy studies. Traditionally, the focus has been on commonly overexpressed antigens shared across many patients and/or tumor types. As the field has progressed, the identity of human tumor rejection antigens has broadened. Immunologic monitoring of clinical trials has slowly elucidated candidate biomarkers of immune response and clinical response, and conversely, of immune dysfunction and suppression. We have utilized MART-1/Melan-A in our melanoma studies and observed a high frequency of immune response...περισσότερα »
Immunoreceptor TIGIT inhibits the cytotoxicity of human cytokine-induced killer cells by interacting with CD155
Abstract T cell Ig and ITIM domain (TIGIT) is a newly identified inhibitory receptor expressed on T and natural killer (NK) cells. Cytokine-induced killer (CIK) cells express CD3 and CD56 molecules, and share functional properties with both NK and T cells. However, it remains unknown whether TIGIT is expressed in CIK cells. Here, we show that TIGIT is expressed by CIK cells and interacts with CD155. By blocking TIGIT using an anti-TIGIT functional antibody, we demonstrate that CIK cells display increased proliferation; higher cytotoxic targeting of tumor cells expressing CD155; and... περισσότερα »
Change in Speech Perception and Auditory Evoked Potentials over Time after Unilateral Cochlear Implantation in Postlingually Deaf Adults
Change in Speech Perception and Auditory Evoked Potentials over Time after Unilateral Cochlear Implantation in Postlingually Deaf Adults: Semin Hear 2016; 37: 062-073 DOI: 10.1055/s-0035-1570329 Speech perception varies widely across cochlear implant (CI) users and typically improves over time after implantation. There is also some evidence for improved auditory evoked potentials (shorter latencies, larger amplitudes) after implantation but few longitudinal studies have examined the relationship between behavioral and evoked potential measures after implantation in postlingually de...περισσότερα »
Cortical Auditory Evoked Potentials Reveal Changes in Audibility with Nonlinear Frequency Compression in Hearing Aids for Children: Clinical Implications
Cortical Auditory Evoked Potentials Reveal Changes in Audibility with Nonlinear Frequency Compression in Hearing Aids for Children: Clinical Implications: Semin Hear 2016; 37: 025-035 DOI: 10.1055/s-0035-1570332 Hearing loss in children is detected soon after birth via newborn hearing screening. Procedures for early hearing assessment and hearing aid fitting are well established, but methods for evaluating the effectiveness of amplification for young children are limited. One promising approach to validating hearing aid fittings is to measure cortical auditory evoked potentials (C... περισσότερα »
Cortical Auditory Evoked Potentials in the Treatment of Infant Hearing Loss
Clinical Experience of Using Cortical Auditory Evoked Potentials in the Treatment of Infant Hearing Loss in Australia: Semin Hear 2016; 37: 036-052 DOI: 10.1055/s-0035-1570331 This article presents the clinical protocol that is currently being used within Australian Hearing for infant hearing aid evaluation using cortical auditory evoked potentials (CAEPs). CAEP testing is performed in the free field at two stimulus levels (65 dB sound pressure level [SPL], followed by 55 or 75 dB SPL) using three brief frequency-distinct speech sounds /m/, /ɡ/, and /t/, within a standard audiologi... περισσότερα »
Cortical Auditory Evoked Potentials in (Un)aided Normal-Hearing and Hearing-Impaired Adults
Cortical Auditory Evoked Potentials in (Un)aided Normal-Hearing and Hearing-Impaired Adults: Semin Hear 2016; 37: 009-024 DOI: 10.1055/s-0035-1570333 Cortical auditory evoked potentials (CAEPs) are influenced by the characteristics of the stimulus, including level and hearing aid gain. Previous studies have measured CAEPs aided and unaided in individuals with normal hearing. There is a significant difference between providing amplification to a person with normal hearing and a person with hearing loss. This study investigated this difference and the effects of stimulus signal-to-n... περισσότερα »
Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder
Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder: Semin Hear 2016; 37: 053-061 DOI: 10.1055/s-0035-1570330 With the introduction of newborn hearing screening, infants are being diagnosed with hearing loss during the first few months of life. For infants with a sensory/neural hearing loss (SNHL), the audiogram can be estimated objectively using auditory brainstem response (ABR) testing and hearing aids prescribed accordingly. However, for infants with auditory n... περισσότερα »
Maturation of the Central Auditory Nervous System in Children with Auditory Processing Disorder
Maturation of the Central Auditory Nervous System in Children with Auditory Processing Disorder: Semin Hear 2016; 37: 074-083 DOI: 10.1055/s-0035-1570328 Neurodevelopmental delay has been proposed as the underlying cause of the majority of cases of auditory processing disorder (APD). The current study employs the cortical auditory evoked potential (CAEP) to assess if maturational differences of the central auditory nervous system (CANS) can be identified between children who do and do not meet the diagnostic criterion for APD. The P1-N1 complex of the CAEP has previously been used ... περισσότερα »
An Optimal Set of Flesh Points on Tongue and Lips for Speech-Movement Classification
An Optimal Set of Flesh Points on Tongue and Lips for Speech-Movement Classification: Purpose The authors sought to determine an optimal set of flesh points on the tongue and lips for classifying speech movements. Method The authors used electromagnetic articulographs (Carstens AG500 and NDI Wave) to record tongue and lip movements from 13 healthy talkers who articulated 8 vowels, 11 consonants, a phonetically balanced set of words, and a set of short phrases during the recording. We used a machine-learning classifier (support-vector machine) to classify the speech stimuli on the ...περισσότερα »
Self-Expanding Metal Stents for Acute Refractory Esophageal Variceal Bleeding: A Systematic Review and Meta-analysis
Self-Expanding Metal Stents for Acute Refractory Esophageal Variceal Bleeding: A Systematic Review and Meta-analysis: Objectives Esophageal variceal bleeding is a severe complication of portal hypertension with significant morbidity and mortality. A substantial portion of cirrhotics fail to respond to conventional medical therapy and band ligation, necessitating alternative treatments including SEMS placement for acute refractory esophageal variceal bleeding. To perform a systematic review and structured meta-analysis of all eligible studies to evaluate the technically feasibility,... περισσότερα »
Orthovoltage for basal cell carcinoma of the head and neck
Orthovoltage for basal cell carcinoma of the head and neck: Excellent local control and low toxicity profile: Objectives/Hypothesis Evaluation of treatment results of orthovoltage X-rays for a selection of previously untreated favorable basal cell carcinomas (BCC) in the head and neck area concerning local control, cosmetic and functional outcome, and toxicity profile. Methods A consecutive series of patients with primarily treated BCCs who were irradiated by means of orthovoltage X-rays in the Netherlands Cancer Institute in Amsterdam between January 2000 and February 2015 were re...περισσότερα »
Intraductal pneumatic lithotripsy for salivary stones with the StoneBreaker: Preliminary experience
Intraductal pneumatic lithotripsy for salivary stones with the StoneBreaker: Preliminary experience: Objectives/Hypothesis To test the effectiveness of a newly approved pneumatic lithotripter for fragmentation of salivary stones. Study Design Retrospective study in a tertiary referral center. Methods In 44 patients, 49 stones were primarily treated with direct endoscopic guidance using the StoneBreaker. Twenty-three stones were located in the parotid gland and 26 in the submandibular gland. Results Complete fragmentation was achieved combined extracorporeal in 97.7% of the stones. Al...περισσότερα »
Two-stage autotransplantation of the human submandibular gland: First long-term results
Two-stage autotransplantation of the human submandibular gland: First long-term results: Objectives/Hypothesis Xerostomia is still one of the predominant side effects of radiotherapy (RT). This study investigates long-term results of a new surgical method that spares the submandibular gland from radiation. Study Design Eleven patients with head and neck carcinoma were enrolled in the study. In five patients 6-month follow-up testing, and in two of these patients 12-month follow-up testing was performed. Methods The submandibular gland was transplanted to the patients forearm for the ... περισσότερα »
Racial, ethnic, and socioeconomic disparities in pituitary surgery outcomes
Racial, ethnic, and socioeconomic disparities in pituitary surgery outcomes: Objectives/Hypothesis To investigate the association of race, ethnicity, socioeconomic status, and hospital volume with outcomes in pituitary surgery. Study Design Retrospective cross-sectional study of the 2008-2012 National (Nationwide) Inpatient Sample. Methods Patient demographics, hospital characteristics, postoperative complications, and in-hospital mortality for patients undergoing pituitary surgery were compared between white, black, and Hispanic patients. Hierarchal logistic regression analysis was...περισσότερα »
Orthovoltage X-rays for a selection of previously untreated favorable basal cell carcinomas (BCC) in the head and neck area
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Orthovoltage for basal cell carcinoma of the head and neck: Excellent local control and low toxicity profile: Objectives/Hypothesis Evaluation of treatment results of orthovoltage X-rays for a selection of previously untreated favorable basal cell carcinomas (BCC) in the head and neck area concerning local control, cosmetic and functional outcome, and toxicity profile. Methods A consecutive series of patients with primarily treated BCCs who were irradiated by means of orthovoltage X-rays in the Netherlands Cancer Institute in Amsterdam between January 2000 and February 2015 were re...περισσότερα »
The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer
The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer: Objective To summarize the epidemiology of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OSCC). Data Sources Articles in the English language referenced in MEDLINE/PubMed from the year 2000 onward. Review Methods Relevant articles pertaining to the epidemiology of HPV-related OSCC were selected for review, with a particular preference for articles from 2008 onward. Results The incidence of HPV-related OSCC continues to increase in North America and Western Europe,... περισσότερα »
The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer: Objective To summarize the epidemiology of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OSCC). Data Sources Articles in the English language referenced in MEDLINE/PubMed from the year 2000 onward. Review Methods Relevant articles pertaining to the epidemiology of HPV-related OSCC were selected for review, with a particular preference for articles from 2008 onward. Results The incidence of HPV-related OSCC continues to increase in North America and Western Europe,... περισσότερα »
Distribution and characteristics of slow-cycling cells in vocal folds
Distribution and characteristics of slow-cycling cells in rat vocal folds: Objectives/Hypothesis Stem cells are known to proliferate at a slow rate in adult organs, and thus slow-cycling cells exhibiting pluripotency are considered tissue-specific stem cells in some organs. Slow-cycling cells in the vocal fold (VF) have not been well documented. Here we sought to clarify the distributions and characteristics of slow-cycling cells in rat VFs. Methods We applied double-labeling technique to detect the distribution of slow-cycling cells. We injected the exogenous proliferation marker 5... περισσότερα »
Destructive Hard Palate Mass
Destructive Hard Palate Mass: A woman presented with painful swelling along the roof of her mouth and cheek associated with new-onset malocclusion, ipsilateral upper lip numbness, and a submucosal growth on the mesial aspect of the left maxillary alveolus. What is your diagnosis? [image: First page PDF preview]
Lesion of the Otic Capsule
An Uncommon Lesion of the Otic Capsule: A man in his 40s presented with a gradual-onset, left-sided hearing loss with a whistling tinnitus and occasional sharp otalgia; examination showed a smooth mass behind the left tympanic membrane. What is your diagnosis? [image: First page PDF preview]
Announcements February 2016
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Plv4l5 via IFTTT
TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors
Abstract The success in recent clinical trials using T cell receptor (TCR)-genetically engineered T cells to treat melanoma has encouraged the use of this approach toward other malignancies and viral infections. Although hepatitis C virus (HCV) infection is being treated with a new set of successful direct anti-viral agents, potential for virologic breakthrough or relapse by immune escape variants remains. Additionally, many HCV+ patients have HCV-associated disease, including hepatocellular carcinoma (HCC), which does not respond to these novel drugs. Further exploration of other... περισσότερα »
In vitro and in vivo efficacy and safety evaluation of metapristone and mifepristone as cancer metastatic chemopreventive agents
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Jichuang Wang, Jianzhong Chen, Yewei Zhu, Ning Zheng, Jian Liu, Yingying Xiao, Yusheng Lu, Haiyan Dong, Jingjing Xie, Suhong Yu, Jingwei Shao, Lee Jia Malignant melanoma, the most deadly form of skin cancer, has a high propensity for metastatic spread and is notoriously chemotherapy-resistant. Metapristone is the primary metabolite of mifepristone (RU486) and shows biological activities similar to RU486. In the present study, we comprehensively investigated the efficacy of metapristone as a met... περισσότερα »
Transforming growth-beta 1 contributes to isoflurane postconditioning against cerebral ischemia–reperfusion injury by regulating the c-Jun N-terminal kinase signaling pathway
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Sheng Wang, Jiangwen Yin, Mingyue Ge, Zhigang Dai, Yan Li, Junqiang Si, Ketao Ma, Li Li, Shanglong Yao AimCerebral ischemia–reperfusion (I/R) injury is a devastating complication in the perioperative period. Transforming growth factor beta (TGF-β) is a key protein that can participate in the repair and control process responses after I/R injury. Isoflurane is widely used in neurosurgery. Previous studies have shown that isoflurane preconditioning plays an important role in neuroprotection. Howe... περισσότερα »
Let-7a mimic attenuates CCL18 induced breast cancer cell metastasis through Lin 28 pathway
Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Lei Wang, Yu-xia Wang, De-zhong Zhang, Xiang-jie Fang, Pei-sheng Sun, Hui-chao Xue BackgroundMicroRNAs are believed to influence breast cancer cell tumorgenicity by interacting with the production of tumor associated macrophages. At this stage, this hypothesis lacks sufficient empirical evidence. Our study is an investigation of the effects of let-7a on the function of human breast cancer cell lines that had undergone chemokine ligand 18 (CCL18) stimulation.MethodsTwo breast cancer cell lines ... περισσότερα »
The styloauricular muscle: clinical relevance and literature review of this rare muscle
Abstract Purpose In humans, the styloauricularis is a rare muscle extending from the tragal cartilage of the auricle to the styloid process. When it contracts, by bearing on the styloid process, it increases the cephalo-auricular angle. It can be a landmark for the facial nerve. We report a case with bilateral presence of the styloauricularis. Methods Bilateral presence of the styloauricularis was discovered during routine dissection of the head and neck. Results In the presented case, styloauricularis muscles arose from the cartilage of the external acoustic meatus on both side... περισσότερα »
Anatomical and computed tomography study of the eighth costochondral junction: topography for costochondral graft harvesting
Abstract Introduction Costochondral grafts have long been used in maxillofacial reconstruction, but have been little used in trauma and orthopedic cases. This surgical technique requires that a graft be harvested from the thorax in the area of the eighth rib. Pleuropulmonary complications are very rare. Although the harvesting technique is simple, it needs to be demystified. Goal of study This study was performed to define anatomical relationships in the eighth costochondral junction and identify topographical and anatomical landmarks that will make it easier to harvest this struc... περισσότερα »
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma: This study evaluates the usefulness of preoperative ultrasound characteristics in predicting pathologic extranodal extension in patients with metastatic papillary thyroid carcinoma. *Importance* The presence of extranodal extension (ENE) in metastatic papillary thyroid carcinoma (PTC) has emerged as an important prognostic factor, independently associated with tumor persistence after initial resection, decreased likelihood of complete biochemical response, and worse cause-specific survival. Therefore, the a... περισσότερα »
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma: This study evaluates the usefulness of preoperative ultrasound characteristics in predicting pathologic extranodal extension in patients with metastatic papillary thyroid carcinoma. *Importance* The presence of extranodal extension (ENE) in metastatic papillary thyroid carcinoma (PTC) has emerged as an important prognostic factor, independently associated with tumor persistence after initial resection, decreased likelihood of complete biochemical response, and worse cause-specific survival. Therefore, the abi... περισσότερα »
HPV status is associated with altered PIWI-interacting RNA expression pattern
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer via ScienceDirect Publication: Oral Oncology Publication date: Available online 4 February 2016 *Source:*Oral Oncology Author(s): Natalie Firmino, Victor D. Martinez, David A. Rowbotham, Katey S.S. Enfield, Kevin L. Bennewith, Wan L. Lam ObjectivesAs HPV-induced cases of oral malignancy increase, it is important to understand the molecular differences between HPV positive and negative head and neck squamous cell carcinoma (HNSCC). PIWI-interacting RNAs (piRNAs) are a class of small non... περισσότερα »
Inpatient Tonsillectomy in Children 36 Months and Younger
Inpatient Tonsillectomy in Children 36 Months and Younger: This study assesses complications following inpatient extracapsular tonsillectomy in children. *Importance* Tonsillectomy is among the most common surgical procedures performed by general and pediatric otolaryngologists. Inpatient surgery is generally recommended for children 36 months and younger owing to concern for a higher incidence of postoperative complications. *Objective* To ascertain the need for a planned inpatient stay for extracapsular tonsillectomy in children 36 months and younger . *Design, Setting, and Pa...περισσότερα »
TORS for Obstructive Sleep Apnea–Hypopnea Syndrome
TORS for Obstructive Sleep Apnea–Hypopnea Syndrome: AbstractTrans oral robotic surgery is currently one of several surgical strategies in managing tongue base obstruction in sleep apnea patients. This article outlines a novel way to treat obstructive sleep apnea lingual obstruction using the da Vinci robotic surgical system. This technique offers significant potential advantages over other established approaches and it should be included in the surgical armamentarium of sleep surgeons. Despite a large body of favorable retrospective data, prospective studies are not currently avail... περισσότερα »
Temporal epilepsy lesions may be detected by the voxel-based quantitative analysis of brain FDG-PET images using an original block-matching normalization software
Abstract Introduction Statistical parametric mapping (SPM) provides useful voxel-by-voxel analyses of brain images from 18F-fluorodesoxyglucose positron emission tomography (FDG-PET) after an initial step of spatial normalization through an anatomical template model. In the setting of the preoperative workup of patients with temporal epilepsy, this study aimed at assessing a block-matching (BM) normalization method, where most transformations are computed through small blocks, a principle that minimizes artefacts and overcomes additional image-filtering. Methods Brain FDG-PET ima... περισσότερα »
Should medics intubate out-of-hospital cardiac arrest patients?
Should medics intubate out-of-hospital cardiac arrest patients?: By Christopher T. Boyer The American Heart Association *2015 guidelines* for CPR and Emergency Cardiac Care are somewhat inconclusive about advanced airway management for patients in cardiac arrest. The guidelines stipulate that "there is no high-quality evidence favoring the use of endotracheal intubation compared with bag-mask ventilation or an advanced airway device in relation to overall survival or favorable neurologic outcome [1]." The available research studies are often skewed due to a perceived selection bia... περισσότερα »
Plasma therapy against infectious pathogens
Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow.: [image: http:--linkinghub.elsevier.com-ihub-imag] Transfus Clin Biol. 2016 Jan ; Authors: Garraud O, Heshmati F, Pozzetto B, Lefrere F, Girot R, Saillol A, Laperche S Abstract Plasma therapy consists in bringing to a patient in need - in general suffering a severe, resistant to current therapy, and even lethal infection - plasma or specific, fractioned, antibodies, along with other immunoglobulins and possibly healing factors that can be obtained from immunized blood donors; donors (voluntary and ... περισσότερα »
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.
The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome Antimicrob Agents Chemother. 2016 Jan 19; Authors: Baranovich T, Jones JC, Russier M, Vogel P, Szretter KJ, Sloan SE, Seiler P, Trevejo JM, Webby RJ, Govorkova EA Abstract Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting the stem of the influe...περισσότερα »
Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients.
Economic Impact of a New Rapid PCR Assay for Detecting Influenza Virus in an Emergency Department and Hospitalized Patients PLoS One. 2016;11(1):e0146620 Authors: Soto M, Sampietro-Colom L, Vilella A, Pantoja E, Asenjo M, Arjona R, Hurtado JC, Trilla A, Alvarez-Martínez MJ, Mira A, Vila J, Marcos MA Abstract Seasonal influenza causes significant morbidity and mortality and has a substantial economic impact on the healthcare system. The main objective of this study was to compare the cost per patient for a rapid commercial PCR assay (Xpert® Flu) with an in-house real-time PCR test f...περισσότερα »
H7N9 Live attenuated influenza vaccine is highly immunogenic, prevents virus replication and protects against severe bronchopneumonia in ferrets.
H7N9 Live attenuated influenza vaccine is highly immunogenic, prevents virus replication and protects against severe bronchopneumonia in ferrets Mol Ther. 2016 Jan 22; Authors: de Jonge J, Isakova-Sivak I, van Dijken H, Spijkers S, Mouthaan J, de Jong R, Smolonogina T, Roholl P, Rudenko L Abstract Avian influenza viruses continue to cross the species barrier and may such a virus become transmissible among humans this would pose a great threat to public health. H7N9 emerged in China in 2013 and has since caused considerable morbidity and mortality. In the absence of a universal inf...περισσότερα »
Passive immunotherapy using polyclonal antibodies (immunoglobulins)
Benefits of using heterologous polyclonal antibodies and potential applications to new and undertreated infectious pathogens.: Vaccine. 2016 Jan 20; Authors: Dixit R, Herz J, Dalton R, Booy R Abstract BACKGROUND: Passive immunotherapy using polyclonal antibodies (immunoglobulins) has been used for over a century in the treatment and post-exposure prophylaxis of various infections and toxins. Heterologous polyclonal antibodies are obtained from animals hyperimmunised with a pathogen or toxin. AIMS: The aims of this review are to examine the history of animal polyclonal antibody th... περισσότερα »
Reconstruction of nasal tip support in primary, open approach septorhinoplasty
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The reconstruction of the nasal tip support is one of the most essential issues in septorhinoplasty. A comparison of the results after using the tongue-in-groove technique and the columellar strut technique was the target of this study. Thirty-three patients who underwent a primary, open approach septorhinoplasty using the above-mentioned techniques were retrospectively analyzed. The […]
Death rate
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Death rate: The number of deaths in the population divided by the average population (or the population at midyear) is the crude death rate. In 1994, for example, the crude death rate per 1,000 population was 8.8 in the United States, 7.1 in Australia, etc. A death rate can also be tabulated according to age […]
Announcements February 2016
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Plv4l5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The Trajectory of Popularity Goal During the Transition to Middle School
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The trajectory of early adolescents’ popularity goal during the transition to middle school was examined in a diverse sample of 401 students. Popularity goal was assessed at five time points from the spring semester of fifth grade through the spring semester of seventh grade with the transition to middle school occurring between the fifth and […]
Temozolomide-induced biliary ductopenia: a case report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Temozolomide is an alkylating agent used along with concurrent radiation therapy in the treatment of glioblastoma. The primary adverse effect of temozolomide is bone marrow suppression with resulting cytopenias. There have been reported cases of temozolomide-induced hepatotoxicity, including fatal liver failure, associated with reactivation of the hepatitis virus or with concurrent use of other […]
Reactivation of telomerase in cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Activation of telomerase is a critical step in the development of about 85 % of human cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are limiting in normal somatic cells. Tert is subjected to transcriptional, post-transcriptional and epigenetic regulation, but the precise mechanism of how telomerase is re-activated in cancer […]
The epigenetic role of vitamin C in health and disease
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Recent advances have uncovered a previously unknown function of vitamin C in epigenetic regulation. Vitamin C exists predominantly as an ascorbate anion under physiological pH conditions. Ascorbate was discovered as a cofactor for methylcytosine dioxygenases that are responsible for DNA demethylation, and also as a likely cofactor for some JmjC domain-containing histone demethylases that […]
Parkinson’s disease: towards better preclinical models and personalized treatments
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SwE4K8 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The Challenge of Immunoglobulin-G Subclass Deficiency and Specific Polysaccharide Antibody Deficiency – a Dutch Pediatric Cohort Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose Immunoglobulin(Ig)G-subclass deficiency and specific polysaccharide antibody deficiency (SPAD) are among the most frequent causes of recurrent respiratory infections in children. Little is known about their prevalence, clinical presentation and prognosis. No study has been published in a Western-European nor in a mainly non-tertiary cohort until now. Therefore, we performed this observational cohort study […]
Muslims and Medical Ethics: Time to Move Forward by Going Back
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QJWrYq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Probiotics can modulate immunity and reduce upper respiratory tract infections (URTI)
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--media.wiley.com-assets-7315-19-Wi] *Consumption of Bifidobacterium animalis subsp. lactis BB-12 impacts upper respiratory tract infection and the function of NK and T cells in healthy adults.* Mol Nutr Food Res. 2016 Jan 28; Authors: Meng H, Lee Y, Ba Z, Peng J, Lin J, Boyer AS, Fleming JA, Furumoto EJ, Roberts RF, Kris-Etherton PM, Rogers CJ Abstract SCOPE: Probiotics can modulate immunity and reduce upper respiratory tract infections (URTI) in humans; however few studies have examined both outcomes in the same ... περισσότερα »
Predictable swallowing function after open horizontal supraglottic partial laryngectomy
Predictable swallowing function after open horizontal supraglottic partial laryngectomy: After horizontal supraglottic partial laryngectomy, patients have an increased risk of dysphagia as they are not able to close the laryngeal entrance during swallowing, especially if the surgical defect of the tongue base has increased. There is no investigation that studies risk factors for impaired swallow function, or that predicts postoperative swallow outcomes based on radiologically determined tumor dimensions. The present study investigated the impact of the tongue base tumor extension (d... περισσότερα »
The human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis: To evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of juvenile-onset recurrent respiratory papillomatosis (RRP) when administered to a group of patients with this condition. AbstractObjective To evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of juvenile-onset recurrent respiratory... περισσότερα »
3D-Visualisierung und Analyse von Stimmlippenschwingungen
3D-Visualisierung und Analyse von Stimmlippenschwingungen: Zusammenfassung HintergrundHeutige visuelle Untersuchungsmethoden des Kehlkopfes und der Stimmlippenbewegung erlauben vorwiegend eine zweidimensionale Darstellung der real dreidimensionalen Strukturen und Bewegungen. Die vertikale Bewegungskomponente der Stimmlippen wird meist vernachlässigt, was zu einem Informationsverlust führt. Neuere Studien zeigen, dass die vertikale Komponente in einer ähnlichen Größenordnung wie die laterale Komponente liegt und einen nicht unerheblichen Anteil am Phonationsprozess hat. Ziel der... περισσότερα »
Improved Gustatory Sensitivity in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy
Improved Gustatory Sensitivity in Morbidly Obese Patients After Laparoscopic Sleeve Gastrectomy: Introduction: The reduction in the preferences for sweet and fat containing tastes in obese patients who underwent bariatric surgery was relatively well shown; however, there are only limited data on the changes in the sensitivity of other tastes like sour, salty, and bitter. Methods: We investigated the changes in gustatory sensitivity of 52 morbidly obese patients (M/F, 22/30; age range, 19-60 years; BMI range, 32.5-63.0 kg/m2) after laparoscopic sleeve gastrectomy. The surgery was pe... περισσότερα »
Balance Disorders in the Elderly: Does Instability Increase Over Time?
Balance Disorders in the Elderly: Does Instability Increase Over Time?: Objectives: To analyze the equilibriometric differences between 2 populations of elderly patients (young elderly and very elderly) with instability induced solely by age. Methods: Cross-sectional study, with 2 study groups classified according to patient age (cut-points in twenty-fifth and seventy-fifth percentiles of the age of the sample). Population: 64 patients aged 65 years or more. Two groups of 32 subjects were established: group A (people 65 years of age or older but less than 72.6, twenty-fifth percen... περισσότερα »
Head and neck cancer : HPV status is associated with altered PIWI-interacting RNA expression pattern
in head and neck cancer via ScienceDirect Publication: Oral Oncology Publication date: Available online 4 February 2016 *Source:*Oral Oncology Author(s): Natalie Firmino, Victor D. Martinez, David A. Rowbotham, Katey S.S. Enfield, Kevin L. Bennewith, Wan L. Lam ObjectivesAs HPV-induced cases of oral malignancy increase, it is important to understand the molecular differences between HPV positive and negative head and neck squamous cell carcinoma (HNSCC). PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs aberrantly expressed in cancer. We analyzed global piRNA express... περισσότερα »
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis: Abstract BackgroundIn Canada, 4,400 cases of oral cancer are diagnosed yearly. Surgical resection is a key component of treatment in many of these cancers. Reconstruction of defects, with the goal of preserving function, is of utmost importance. Several choices are possible for reconstruction of larger defects, including both free and pedicled flaps. Free flap reconstruction is reliable and effective, but requires add... περισσότερα »
Metapristone and mifepristone as cancer metastatic chemopreventive agents
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
In vitro and in vivo efficacy and safety evaluation of via Biomedicine & Pharmacotherapy Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Jichuang Wang, Jianzhong Chen, Yewei Zhu, Ning Zheng, Jian Liu, Yingying Xiao, Yusheng Lu, Haiyan Dong, Jingjing Xie, Suhong Yu, Jingwei Shao, Lee Jia Malignant melanoma, the most deadly form of skin cancer, has a high propensity for metastatic spread and is notoriously chemotherapy-resistant. Metapristone is the primary metabolite of mifepristone (RU486) and shows biological activities similar to RU486. In t... περισσότερα »
Οι γυναίκες “φορούν” 515 χημικές ουσίες ! Χημικές ουσίες: Απειλή για τον άνθρωπο στην καθημερινή του ζωή
*5/2/2016 Πώς ξεχωρί ζουμε τα καλλυντι κά που δενέχουνεπι βλαβεί ς ουσί ες | Περι βάλλον| Η ΚΑΘΗΜΕΡΙΝΗ http://www.kathimerini.gr/75291/article/epikairothta/perivallon/pws-3exwrizoyme-ta-kallyntika-poy-den-exoyn-epivlaveis-oysies 1/3 5 Φεβρουαρίου 2016 ΠΕΡΙΒΑΛΛΟΝ ΠΕΡΙΒΑΛΛΟΝ 23.01.2012 Πώς ξεχωρίζουμε τα καλλυντικά που δεν έχουν επιβλαβείς ουσίες Πώς ξεχωρίζουμε τα καλλυντικά που δεν έχουν επιβλαβείς ουσίες Υπάρχουν συμβατικά, οικολογικά, οικοβιολογικά, με μεγάλες διαφορές μεταξύ τους Της ΙΩΑΝΝΑΣ ΦΩΤΙΑΔΗ Στα ράφια των καταστημάτων με καλλυντικά οι επιθετικοί προσδιορισμοί των προϊόντω... περισσότερα »
Deodorants
Deodorant *From Wikipedia, the free encyclopedia* *Roll-on deodorant Rexona "Degree" brand* *A deodorant is a substance applied to the body to prevent body odor caused by the bacterial breakdown of perspiration in armpits, feet, and other areas of the body. A subgroup of deodorants, antiperspirants, affect odor as well as prevent sweating by affecting sweat glands.* *Antiperspirants are typically applied to the underarms, while deodorants may also be used on feet and other areas in the form of body sprays. In the United States, the Food and Drug Administration classifies and regulates... περισσότερα »
Parabens are a class of widely used preservatives in cosmetic products.Methylparaben applied on the skin may react with UVB leading to increased skin aging and DNA damage.Even small amounts of parabens introduced in vitro stimulate breast cancer cell proliferation
Paraben *From Wikipedia, the free encyclopedia* *General chemical structure of a paraben(a para-hydroxybenzoate)where R = an alkyl group* *Parabens are a class of widely used preservatives in cosmetic and pharmaceutical products. Chemically, they are a series of parahydroxybenzoates or esters of parahydroxybenzoic acid (also known as 4-hydroxybenzoic acid). Parabens are effective preservatives in many types of formulas. These compounds, and their salts, are used primarily for their bactericidal and fungicidal properties. They can be found in shampoos, commercial moisturizers, shav... περισσότερα »
6. Phototherapy, Photomedicine, and Pigmentary Disorders
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PWfNq7 via IFTTT
NAD(P)H dehydrogenase, quinone 1 (NQO1) protects melanin-producing cells from cytotoxicity of rhododendrol
Summary Rhododendrol (RD) is a potent tyrosinase inhibitor that is metabolized to RD-quinone by tyrosinase, which may underlie the cytotoxicity of RD and leukoderma of the skin that may result. We have examined how forced expression of the NAD(P)H quinone dehydrogenase, quinone 1 (NQO1), a major quinone-reducing enzyme in cytosol, affects the survival of RD-treated cells. We found that treatment of the mouse melanoma cell line B16BL6 or normal human melanocytes with carnosic acid, a transcriptional inducer of the *NQO1* gene, notably suppressed the cell killing effect of RD. This ...περισσότερα »
Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 –2015
Abstract Actinic prurigo (AP) is a chronic photosensitivity disease, which is mainly described in Amerindians and rarely in Caucasians1-6. The pathogenesis of AP is unclear, although familial occurrence is often seen, with a strong association with HLA DR4 and in particular HLA DRB1*0407, which is present only rarely in the general population7,8. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/20vpEON via IFTTT
CRE bacteria: What you should know
from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/23MMQHy via IFTTT
Polypöse Strukturen im Bulbus duodeni
Schleimhautveränderungen Ein 24-Jähriger klagt über diffuse Magenbeschwerden. Unabhängig von der Mahlzeit verspüre er einen manchmal über Stunden anhaltenden Druck in der Magengegend. Der Appetit sei gut, der Stuhlgang unauffällig. Gewicht hat er nicht verloren. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/23MMQHs via IFTTT
Cerebral tissue oxygen saturation values in volunteers and patients in the lateral decubitus and beach chair positions: a prospective observational study
Abstract Background The objective of this study was to describe changes in cerebral tissue oxygen saturation (SctO2) due to changes in body position in healthy volunteers and in patients undergoing surgery under general anesthesia in the beach chair position (BCP) and lateral decubitus position (LDP). Methods In this prospective observational study, SctO2 was measured in… Continue reading Cerebral tissue oxygen saturation values in volunteers and patients in the lateral decubitus and beach chair positions: a prospective observational study
Frequency and characteristics of healthcare visits associated with chronic pain: results from a population-based Canadian study
Abstract Purpose This study was designed to investigate the role of chronic pain in healthcare visits. The specific objectives were to document the frequency of healthcare visits and to identify characteristics associated with frequent visits. Methods This is a secondary analysis of data from a Canadian cross-sectional study on chronic pain. One thousand two hundred… Continue reading Frequency and characteristics of healthcare visits associated with chronic pain: results from a population-based Canadian study
BMC Immunology reviewer acknowledgement, 2015
Contributing reviewers The editors of BMC Immunology would like to thank all our reviewers who have contributed their time to the journal in Volume 16 (2015). from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1VTasEE via IFTTT
Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis
Abstract Background In Canada, 4,400 cases of oral cancer are diagnosed yearly. Surgical resection is a key component of treatment in many of these cancers. Reconstruction of defects, with the goal of preserving function, is of utmost importance. Several choices are possible for reconstruction of larger defects, including both free and pedicled flaps. Free flap… Continue reading Submental island flap reconstruction reduces cost in oral cancer reconstruction compared to radial forearm free flap reconstruction: a case series and cost analysis
Journal of Otolaryngology – Head & Neck Surgery reviewer acknowledgement 2015
Contributing reviewers The Editors of Journal of Otolaryngology – Head & Neck Surgery would like to thank all our reviewers who have contributed their time and expertise to the journal in Volume 44 (2015). from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1nR3chW via IFTTT
Reconstruction of nasal tip support in primary, open approach septorhinoplasty
Abstract The reconstruction of the nasal tip support is one of the most essential issues in septorhinoplasty. A comparison of the results after using the tongue-in-groove technique and the columellar strut technique was the target of this study. Thirty-three patients who underwent a primary, open approach septorhinoplasty using the above-mentioned techniques were retrospectively analyzed. The… Continue reading Reconstruction of nasal tip support in primary, open approach septorhinoplasty
Announcements February 2016
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1Plv4l5 via IFTTT
Reviewer acknowledgement 2015
Contributing reviewers The Editor of Journal of Venomous Animals and Toxins including Tropical Diseases would like to thank all of our reviewers, both external and Editorial Board Members, who have contributed to the journal in Volume 21 (2015) and whose valuable support is fundamental to the success of the journal. from #Medicine-Sfakianakis via simeraentaxei on… Continue reading Reviewer acknowledgement 2015
Origin of the spin Seebeck effect in compensated ferrimagnets
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Ferrimagnets possess multiple spin sub-lattices resulting in a complex magnon band structure and subtle spin transport across interfaces. Here, the authors show how the spin Seebeck effect, the thermal generation of pure spin current, may be an effective tool to study these magnetic excitations. Nature Communications doi: 10.1038/ncomms10452 Authors: Stephan Geprägs, Andreas Kehlberger, Francesco […]
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Panicle architecture is an important determinant of crop yield and a target of selection by plant breeders. Here, Crowell et al. combine image-based phenotyping with high-density array-based genotyping to perform a genome-wide association study revealing a number of candidate genes linked to panicle variation in rice. Nature Communications doi: 10.1038/ncomms10527 Authors: Samuel Crowell, Pavel […]
Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Nitric oxide is a volatile free radical second messenger with a large number of biological effects. Here Eroglu et al . develop genetically encoded fluorescent biosensors for nitric oxide and use them to visualise subcellular nitric oxide dynamics in single cells. Nature Communications doi: 10.1038/ncomms10623 Authors: Emrah Eroglu, Benjamin Gottschalk, Suphachai Charoensin, Sandra Blass, […]
MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al . show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity. Nature Communications doi: 10.1038/ncomms10552 Authors: Derek J. C. Tai, Yen C. Liu, Wei L. Hsu, Yun L. […]
Cellular delivery and photochemical release of a caged inositol-pyrophosphate induces PH-domain translocation in cellulo
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Photocaged inositol-pyrophosphates offer a tool to study cellular signalling, but their challenging synthesis has precluded any biological studies so far. Here, the authors report the synthesis and cellular delivery of a photocaged analogue, and show that it mediates protein translocation in cellulo . Nature Communications doi: 10.1038/ncomms10622 Authors: Igor Pavlovic, Divyeshsinh T. Thakor, Jessica […]
Intra-Abdominal and Abdominal Wall Desmoid Fibromatosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Desmoid fibromatosis is a rare but locally aggressive tumor comprised of myofibroblasts. Desmoids do not have the ability to metastasize but can cause significant morbidity and mortality by local invasion. These tumors may occur throughout the body, but are commonly found on the abdominal wall and within the intestinal mesentery. Desmoids in these areas […]
Blocking p53 Aggregation Restores Its Activity and Suppresses Tumors Ovarian Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The ReACp53 peptide reactivates p53 and reduces the growth of p53-mutant ovarian carcinomas. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20doB0p via IFTTT
RRAGC Mutations Activate mTORC1 Signaling in Follicular Lymphoma Lymphoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
RRAGC mutations in follicular lymphoma activate mTORC1, even during amino acid depletion. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R8l9ns via IFTTT
Midostaurin + Chemo Ups AML Survival News in Brief
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
In a phase III clinical trial, previously untreated patients with acute myeloid leukemia and FLT3 mutations received either the FLT3 inhibitor midostaurin or a placebo during chemotherapy. Patients who received midostaurin had a 5-year survival rate of 50.9% compared with 43.9% for the placebo group, as well as remissions that lasted nearly a year longer. […]
The Genomes of Patients with Familial Pancreatic Cancer Research Briefs
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2020. A familial aggregation of pancreatic cancer has been established, but the cause of this aggregation in most families is unknown. To determine the genetic basis of susceptibility in these families, we sequenced the germline genomes of […]
Checkpoint Inhibitors Boost Power of Antibody-Drug Con{#x0237}ugate News in Brief
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The antibody–drug conjugate T-DM1 spurs immune cells to infiltrate HER2-positive breast tumors in patients. Treating mice that carry breast tumors with T-DM1 improves survival, but the tumors suppress the infiltrating lymphocytes. Combining T-DM1 with checkpoint inhibitors that block CTLA-4 and PD-1 overcomes this effect, eliminating breast tumors from 95% of the mice. from #Medicine-SfakianakisAlexandros via […]
IDH Mutations Promote Glioma through Epigenetic Insulator Disruption Glioma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Disrupted CTCF binding at the PDGFRA boundary element enhances its expression, promoting glioma growth. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PY52tw via IFTTT
T-DM1 Extends Survival in HER2+ Breast Cancer News in Brief
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Results from the phase III TH3RESA study show that T-DM1 is effective in patients with metastatic HER2-positive breast cancer that has progressed despite two or more HER2-targeted therapies, extending their median overall survival by nearly 7 months. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R8l971 via IFTTT
DNA-Guided Precision Medicine for Cancer: A Case of Irrational Exuberance? In Focus
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary: Precision treatment with targeted cancer drugs requires the selection of patients who are most likely to benefit from a given therapy. We argue here that the use of a combination of both DNA and transcriptome analyses will significantly improve drug response prediction. Cancer Discov; 6(2); 130–2. ©2016 AACR. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
Targeting RSPO3 Reduces Stem Cell Function in PTPRK-RSPO3 Colon Tumors Colorectal Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Inhibition of RSPO3 induces differentiation of PTPRK–RSPO3 fusion–positive colon tumors. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R8l96R via IFTTT
Nonthermal Atmospheric Plasmas in Dental Restoration
It is well known that the service life of contemporary composite restoration is unsatisfactory, and longevity of dentin bonding is one of the major culprits. Bonding is essentially a hybridization process in which dental substrate and adhesive resin interact with each other through an exchange process. Thus, the longevity of dentin bonding can only be improved with enhanced qualities in substrate, adhesive resin, and their interaction within the hybridization zone. This review aims to collect and summarize recent advances in utilizing nonthermal atmospheric plasmas (NTAPs)—a novel... περισσότερα »
Traumatic globe dislocation into the paranasal sinuses: literature review and treatment guidelines
Traumatic globe dislocation into the paranasal sinuses is rare. Only 24 cases have been reported in the English-language literature indexed in PUBMED. This form of injury frequently occurs as a result of high-energy blunt trauma mainly associated to traffic accidents. Traumatic globe dislocation into the paranasal sinuses can be explained by the mechanism of blowout fracture when strong blunt trauma forces are applied to the globe fracturing the thin orbital walls and displacing the eyeball. Medical and surgical management of severe globe displacement is still controversial. from ... περισσότερα »
Clinicopathological analysis of salivary gland tumors over a 15-year period
Abstract Salivary gland tumors (SGT) are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. The aims of the present study were to investigate clinicopathological aspects of SGTs diagnosed at a tertiary health center and compare the findings with epidemiological data from different geographic locations. Cases of tumor in the head and neck region at a single health center in the period between 1995 and 2010 were reviewed. Patient gender, age and ethnic group as well as anatomic location, histological type and clinical behavior of th... περισσότερα »
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