Spontaneous intracranial hypotension (SIH) is characterized by spontaneous postural headache with neck stiffness, nausea, vomiting, tinnitus, and vertigo in patients with low cerebrospinal fluid pressure. Brain MRI Findings With Epidural Blood Patch in Spontaneous Intracranial Hypotension
Clinical Association Between Brain MRI Findings With Epidural Blood Patch in Spontaneous Intracranial Hypotension: Background: *Spontaneous intracranial hypotension (SIH) is characterized by spontaneous postural headache with neck stiffness, nausea, vomiting, tinnitus, and vertigo in patients with low cerebrospinal fluid pressure. *Epidural blood patch (EBP) can be a treatment of choice in patients nonresponsive to the initial noninvasive treatments. We compared brain magnetic resonance imaging (MRI) findings and clinical variables between patients with conservative management only ...περισσότερα »
Dexmedetomidine Versus Midazolam-Fentanyl Combination for Monitored Anesthesia Care During Burr-Hole Surgery for Chronic Subdural Hematoma
Comparison of Dexmedetomidine Versus Midazolam-Fentanyl Combination for Monitored Anesthesia Care During Burr-Hole Surgery for Chronic Subdural Hematoma: Background: Intraoperative movements are marker of inadequate level of sedation and are undesirable during burr-hole surgery under monitored anesthesia care (MAC). It distracts surgeon, hinders surgical procedure, and may lead to iatrogenic complication. Dexmedetomidine has shown to provide excellent analgesia, cooperative sedation with fewer fluctuations in sedation level during MAC. We compared the effect of dexmedetomidine on in... περισσότερα »
Blood biochemistry responses of ducks infected with a velogenic Newcastle disease virus
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Abstract This study investigated the blood biochemistry responses of Pekin ducks (*Anas platyrhynchos domesticus*) experimentally infected with a velogenic Newcastle disease virus (NDV), KUDU 113 strain. One hundred ducklings were used for the study. The ducks were obtained at a week old and randomly divided into three groups. One group was vaccinated against NDV with La Sota vaccine at 3 weeks of age. The vaccinated and unvaccinated groups of 30 ducks each were subsequently challenged with the velogenic NDV after 6 weeks of brooding, while the control group of 40 ducks was not vac... περισσότερα »
The Cerebrovascular Response to Ketamine
The Cerebrovascular Response to Ketamine: A Systematic Review of the Animal and Human Literature: Background: The aim of the study was to perform a systematic review of the literature on the cerebrovascular/cerebral blood flow (CBF) effects of ketamine in both animal and human subjects. Materials and Methods: We searched MEDLINE, BIOSIS, EMBASE, Global Health, SCOPUS, and Cochrane Library from inception to December 2014. Two reviewers independently identified all manuscripts pertaining to the administration of ketamine in both human and animal subjects in which the impact on CBF/c... περισσότερα »
Midline Destructive Lesions in a Cocaine User
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Annals of Neurology: Volume 79, Number 3, March 2016
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Hemodynamic monitoring and management in high-risk surgery
Hemodynamic monitoring and management in high-risk surgery: a survey among Japanese anesthesiologists: AbstractThe aim of this study was to assess the current practices of hemodynamic management in high-risk surgical patients among Japanese anesthesiologists. An invitation letter to the survey, which included 35 questions related to hemodynamic monitoring in high-risk surgery, was mailed to every hospital approved by the Japanese Society of Anesthesiologists (JSA) (1260 hospitals). Of the 692 JSA respondents, 573 completed the survey. Despite reporting a high rate of cardiac output...περισσότερα »
Leukocyte receptor expression in chronic periodontitis
Leukocyte receptor expression in chronic periodontitis: Abstract Background and objectiveMicrobial recognition in the periodontium through specific leukocyte receptors gives rise to the response which in susceptible individuals can lead to periodontal diseases. The aim of this study was to explore the expression of leukocyte receptors in the gingival tissues of chronic periodontitis patients and to analyse differences between diseased and control sites (sites with probing pocket depth <4 mm). Material and methodsThirty-seven chronic periodontitis patients were included in the s... περισσότερα »
Normoxic accumulation of HIF1α is associated with glutaminolysis
Normoxic accumulation of HIF1α is associated with glutaminolysis: Abstract ObjectivesThe stabilization of the transcription factor and prognostic tumor marker hypoxia-inducible factor 1α (HIF1α) is considered to be crucial for cellular metabolic adaptations to hypoxia. However, HIF1α has also been shown to accumulate under normoxic conditions, although this phenomenon is poorly understood. MethodsWe investigated the conditions for normoxic HIF1α stabilization in different tumor cell lines (e.g., two mammary carcinoma cell lines and three oral squamous cell carcinoma cell lines)... περισσότερα »
Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss® or autologous bone grafts. A histo-morphometric study in rabbits
Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss® or autologous bone grafts. A histo-morphometric study in rabbits: Abstract Objective To compare the healing at elevated sinus floors augmented either with deproteinized bovine bone mineral (DBBM) or autologous bone grafts and followed by immediate implant installation. Material and methods Twelve albino New Zealand rabbits were used. Incisions were performed along the midline of the nasal dorsum. The nasal bone was exposed. A circular bony widow with a diameter of 3 mm was prepared bilaterall...περισσότερα »
Self-perceived halitosis influences social interactions
Self-perceived halitosis influences social interactions: Abstract BackgroundTo determine the impact of self-perceived halitosis on social interactions, and the effect of using an oral rinse for management of halitosis. MethodsA survey among a representative sample of the Dutch population (*n* = 1082), and a pre-post study among a sample of consecutive coming-by volunteers (*n* = 292). ResultsParticipants of the representative sample rated their oral odor as 66.8 ± 17.2 and the consecutive volunteers as 70.9 ± 16.7 (range: 0–100). Sizable proportions (15.3 % and 38.1 %, resp... περισσότερα »
Esophageal and Gastric Endoscopic Foreign Body Removal
of 19 Dogs (2009-2011): AbstractThis medical record of 19 dogs with esophageal and/or gastric foreign bodies (FBs) that underwent endoscopic removal from 2009 to 2011 was retrospectively reviewed. Foreign bodies were successfully removed in 18/19 dogs, and just 1 dog failed to remove FB using endoscopy. Eighteen dogs had a good prognosis without severe complications after FB removal, whereas one dog died on 8 days after endoscopy. Although all dogs of this report were small breeds, most cases have good prognosis after FB removal. According to the present study, esophagogastric FBs ...περισσότερα »
Primary Care Physician Perspectives on Hepatitis C Management in the Era of Direct-Acting Antiviral Therapy
Primary Care Physician Perspectives on Hepatitis C Management in the Era of Direct-Acting Antiviral Therapy: Abstract BackgroundPrimary care physicians (PCPs) play a critical role in the care cascade for patients with chronic hepatitis C (CHC). AimTo assess PCP knowledge and perspectives on CHC screening, diagnosis, referral, and treatment. MethodsAn anonymous survey was distributed to PCPs who participated in routine outpatient care at our hospital. ResultsEighty (36 %) eligible PCPs completed the survey. More than half were females (60 %) aged 36–50 (55 %) from family ... περισσότερα »
Drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors
High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors: [image: cover.gif?v=1&s=7839f76471d415b6065969f1] Summary Background Microscopic colitis (MC) is a chronic bowel disorder characterised by watery diarrhoea. Nonsteroidal anti-inflammatory drugs (NSAIDs), proton pump inhibitors (PPIs), selective serotonin reuptake inhibitors (SSRIs) and statins have been associated with MC. However, underlying mechanisms remain unclear. Aim To study the association between exposure to these drugs and MC, with attention to time of exposure, dur... περισσότερα »
Esophageal Amyloidosis : Dysphagia as initial presentation of primary amyloidosis
*CASE REPORT* *Dysphagia as initial presentation of primary amyloidosisPiyush Ranjan, Mohan Goyal, Mandhir Kumar, Munish SachdevaDepartment of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India* *Amyloidosis involves all parts of the gastrointestinal tract including the esophagus. The esophageal involvement in amyloidosis has been reported to vary from 13% in a radiology study to 22% in an autopsy series; however, such patients have symptoms of gastroesophageal reflux. Dysphagia is an uncommon presentation of amyloidosis. We report a 64-year-old patient who presented wi... περισσότερα »
Orbital Sarcoid Mass : Vision Loss After Central Retinal Artery Occlusion
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Vision Loss After Central Retinal Artery Occlusion Secondary to Orbital Sarcoid Mass: [image: image] The authors describe the first report in the literature of central retinal artery occlusion as the presenting manifestation of sarcoidosis. A 33-year-old man with asthma, headache, and 6 days of intermittent, transient vision loss in the OS presented with persistent vision loss in the OS. Ophthalmic examination was consistent with diagnosis of central retinal artery occlusion in the OS. Vascular imaging with CT angiography revealed an incidental finding of an intraconal mass surroun... περισσότερα »
The Self-Reported Use of Immunostains and Cytogenetic Testing in the Diagnosis of Melanoma by Practicing U.S. Pathologists of 10 Selected States
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract Background The diagnosis of melanoma can be challenging, especially in lesions for which the histopathologic criteria bridge two or more taxonomic categories. Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) have been introduced as ancillary techniques to differentiate benign and malignant melanocytic proliferations. Methods We evaluated how pathologists perceive and are incorporating these new cytogenetic testing technologies into their practices. We conducted a study of 207 U.S. pathologists who ... περισσότερα »
Cutaneous Metastasis of Pleomorphic Liposarcoma to the Scalp: An elusive diagnosis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract Liposarcomas are one of the most common sarcomas arising in the extremities of the elderly. Various subtypes of liposarcomas include well-differentiated liposarcomas, dedifferentiated liposarcomas, myxoid liposarcomas, and pleomorphic liposarcomas. Pleomorphic liposarcomas are the rarest subtype and have the highest malignant potential compared to the other subtypes of liposarcomas. Metastases to internal organs are common but cutaneous metastasis is very rare with only few cases in the literature. We present a patient with a known diagnosis of stage IV metastatic liposar... περισσότερα »
Histopathological clues in the diagnosis of fungal infection by Scedosporium in a case of endophthalmitis starting as conjunctivitis
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract Cutaneous fungal infections can result in disastrous episodes if improperly diagnosed and treated, especially in immunosuppressed patients. Although dermatopathologists are highly familiar with some filamentous fungi—such as *Aspergillus* and *Zygomycetes—*they are not so aware of other less common species. We report a case of ocular infection by *Scedosporium apiospermum* that started as conjunctivitis and resulted in *phthisis bulbi* and subsequent exeresis of the left eye. We describe some of the main morphological features of the fungus as well as the important morphol... περισσότερα »
Incidental finding of cutaneous meningeal heterotopia in aplasia cutis congenita_R1
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Abstract Aplasia cutis congenita and cutaneous meningeal heterotopia are both rare congenital conditions that most commonly occur on the scalp and may appear clinically and histologically similar. A subtype of aplasia cutis congenita, membranous aplasia cutis congenita, and cutaneous meningeal heterotopia are both proposed to result from neural tube closure errors. However, neither non-membranous nor membranous aplasia cutis congenita are known to occur together with cutaneous meningeal heterotopia in the same lesion. We report the incidental finding of cutaneous meningeal heteroto...περισσότερα »
Cutaneous Metastasis of Breast Adenoid Cystic Carcinoma to the Scalp
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Abstract Adenoid cystic carcinoma is a tumor that can be of primary cutaneous origin or secondary to metastatic disease, most commonly salivary origin. Aside from primary cutaneous and salivary types, adenoid cystic carcinoma of the breast is a rare, more indolent variant. Cutaneous metastases secondary to breast adenoid cystic carcinoma is exceedingly uncommon and not previously reported to our knowledge. We present the case of a 67 year- old woman who developed cutaneous metastasis from primary breast adenoid cystic carcinoma. from Anatomy Pathology via xlomafota13 on Inoreader ... περισσότερα »
Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Abstract Background Cutaneous lymphadenoma (CL) is rare neoplasm that clinically and histologically resembles basal cell carcinoma (BCC). CL, composed of dermal basaloid epithelial islands with prominent admixed lymphocytes, characteristically contains CK20-positive Merkel cells.. However, CK20 may be of limited use due to low Merkel cell density in small samples. CK17 is expressed diffusely throughout BCC. We investigated the discriminatory utility of CK17 and CK20 in CL and BCC. Methods A retrospective clinicopathological review of 11 cases of CL and 14 BCC was performed. CK20...περισσότερα »
Use of the frozen section “jelly-roll” technique to aid in the diagnosis of bullous congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Abstract Frozen section is a valuable tool that is often underutilized in the setting of in-patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma /epidermolytic hyperkeratosis and epidermolysis bullosa. A thin de... περισσότερα »
Cutaneous Presentation of Disseminated Histoplasmosis as a Solitary Peri-anal Ulcer. Case Report and Discussion
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Abstract Disseminated histoplasmosis has a diverse and non-specific range of clinical signs and symptoms. In a significant minority of patients, cutaneous lesions are apparent at the time of initial presentation, affording an opportunity to establish the diagnosis from a skin biopsy. The most frequently reported clinical scenario in immunocompromised patients with cutaneous involvement is that of multiple papulo-nodular lesions on the face, trunk or extremities. The following report features an immunocompetent patient who presented with a solitary ulcerated plaque on the buttocks ... περισσότερα »
Stimulus-induced pacemaker activity in interstitial cells of Cajal associated with the deep muscular plexus of the small intestine
Abstract Background The ICC-DMP have been proposed to generate stimulus-dependent pacemaker activity, rhythmic transient depolarizations, that take part in orchestrating segmentation and clustered propulsive motor patterns in the small intestine. However, little is known about the fundamental properties of ICC-DMP. Methods This study was undertaken to increase our understanding of intrinsic properties of the ICC-DMP through calcium imaging and intracellular electrical recordings. Key Results Without stimulation, most ICC-DMP were quiescent. In some preparations ICC-DMP generated r...περισσότερα »
Synchronized functional anal sphincter assessment: maximizing the potential of anal vector manometry and 3-D anal endosonography
Abstract Background Understanding the association between structure and function is vital before considering surgery involving anal sphincter division. By correlating three-dimensional anal endosonography (AES) and three-dimensional anal canal vector volume manometry (VVM), this study details a method to produce measurements of both sphincter length and pressure leading to identification of the functionally important areas of the anal canal. The aim of this study was to provide combined detailed information on anal canal anatomy and physiology. Methods Twelve males and 12 nulliparo...περισσότερα »
Methotrexate-induced intestinal mucositis
[image: http:--linkinghub.elsevier.com-ihub-imag] *Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.* J Ethnopharmacol. 2016 ; Authors: Shi CJ, Wen XS, Gao HF, Liu ZH, Xu XK, Li LF, Shen T, Xian CJ Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions. In traditional Chinese medicine, chemotherapeutic toxicity is diagnosed as Qi and Yin deficiency, and steamed rehmannia root (SRR) is fr... περισσότερα »
Crimean-Congo hemorrhagic fever virus
[image: http:--production.springer.de-OnlineReso] *Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.* Arch Virol. 2016 Mar ; Authors: Suda Y, Fukushi S, Tani H, Murakami S, Saijo M, Horimoto T, Shimojima M Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. The experimental use of CCHF virus (CCHFV), which causes CCHF, requires high-biosafety-level (BSL) containment. In contrast, pseudotyping of v... περισσότερα »
Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models.
[image: http:--www.frontiersin.org-alerts-logo-l] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc]Front Oncol. 2016;6:30 Authors: Walenta S, Mueller-Klieser W Abstract This review is focused on the radiobiology of carbon ions compared to X-rays using multicellular models of tumors and normal mucosa. The first part summarizes basic radiobiological effects, as observed in cancer cells. The second, more clinically oriented part of the review, deals with radiation-induced cell migration and mucositis. Multicellular spheroids from V79 hamster cells were irradiated with X-rays or carbo... περισσότερα »
Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.
[image: http:--www.tandfonline.com-templates-jsp] J Dermatolog Treat. 2016 Mar 4;:1-3 Authors: Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G Abstract OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most commonly seen inflammatory disease in the oral mucosa affecting 5%-25% of the general population. The etiology of RAS is still not fully understood and its treatment is very challenging. With its anti-inflammatory affects, colchicine is used for systematic treatment of RAS. In this study, we want to examine the effects of colchicine on platelet density, mean platelet volume (... περισσότερα »
Issue Information – Table of Contents
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Soft Tissue Necrosis in Head and Neck Cancer Patients After Transoral Robotic Surgery or Wide Excision With Primary Closure Followed by Radiation Therapy.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Medicine (Baltimore). 2016 Mar;95(9):e2852 Authors: Yun Hee L, Kim YS, Chung MJ, Yu M, Jung SL, Yoo IeR, Lee YS, Kim MS, Sun DI, Kang JH Abstract Risk factors were evaluated for surgical bed soft tissue necrosis (STN) in head and neck cancer patients treated with postoperative radiation therapy (PORT) after transoral robotic surgery (TORS) or wide excision with primary closure. Sixty-seven patients were evaluated. STN was defined as ulceration and necrosis of the surgical bed or persistently unhealed high-grade acute mucositis wit... περισσότερα »
S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis
S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis: Introduction Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. Aim To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Materials and Methods Oral mucositis was induced in male hamsters by two intraperitoneal administrations of 5-FU on the first and second days of the experiment (60 and 40 mg/kg, respectively) followe... περισσότερα »
Prevalence of Oral and Maxillofacial Trauma in Elders Admitted to a Reference Hospital in Northeastern Brazil
Prevalence of Oral and Maxillofacial Trauma in Elders Admitted to a Reference Hospital in Northeastern Brazil: Objective To know the prevalence and etiology of oral and maxillofacial trauma in elders. Methods Analytical quantitative cross-sectional study conducted at a public trauma hospital located in Fortaleza-Ceará, Brazil. The study population comprised patients with trauma who were hospitalized from April to August 2014. Of these patients, patients with oral and maxillofacial trauma were chosen to be included in the research. A questionnaire was administered in order to ob... περισσότερα »
Clinical Features and Treatment Modes of Mandibular Fracture at the Department of Oral and Maxillofacial Surgery, Shimane University Hospital, Japan
Clinical Features and Treatment Modes of Mandibular Fracture at the Department of Oral and Maxillofacial Surgery, Shimane University Hospital, Japan: Background The number of elderly patients with maxillofacial trauma is rapidly increasing due to active lifestyles and longevity. Shimane prefecture has the fastest growing proportion of elderly individuals in Japan. The aim of this study was to reveal the distinctive features and treatment modes of mandibular fracture treatment mode in patients requiring hospitalization at the Department of Oral and Maxillofacial Surgery, Shimane Uni... περισσότερα »
Issue Information – Copyright
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Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: De Sanctis V, Bossi P, Sanguineti G, Trippa F, Ferrari D, Bacigalupo A, Ripamonti CI, Buglione M, Pergolizzi S, Langendjik JA, Murphy B, Raber-Durlacher J, Russi EG, Lalla RV Abstract BACKGROUND: Oral mucositis (OM) due to radiotherapy and systemic therapies in head and neck cancer treatment represents a major problem causing a wide spectrum of clinical signs and symptoms. This adverse event may reduce quality of life, resulting from debilitating oral pain, bleeding, dysphagia, infections, impairment of food intake, high r... περισσότερα »
Issue Information – Masthead
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Association of serum electrolytes and smoking with salivary gland stone formation
Association of serum electrolytes and smoking with salivary gland stone formation via Oral and Maxillofacial Surgery Publication date: Available online 8 March 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): A.J. Yiu, A. Kalejaiye, R.L. Amdur, H.N. Todd Hesham, B.C. Bandyopadhyay To further define potential factors that may contribute to stone formation in salivary glands (sialolithiasis), a retrospective chart review was performed of patients diagnosed with sialolithiasis between March 1, 1998 and February 29, 2012. Information on salivary gland stone ...περισσότερα »
Partial sialoadenectomy for the treatment of benign tumours in the submandibular gland
Partial sialoadenectomy for the treatment of benign tumours in the submandibular gland: The conventional treatment for benign tumours arising in the submandibular gland (SMG) has always involved whole gland excision with the tumour. In light of developments in parotid gland functional surgery, this prospective study was performed to evaluate the effectiveness and safety of partial sialoadenectomy (PS) for benign tumours in comparison with conventional total sialoadenectomy (TS). Thirty-one consecutive patients with a preoperative diagnosis of benign tumour in the SMG were included... περισσότερα »
Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ)
Effect of hyperbaric oxygen therapy on tooth extraction sites in rats subjected to bisphosphonate therapy—histomorphometric and immunohistochemical analysis: Abstract ObjectiveThis study aimed to investigate the effect of hyperbaric oxygen therapy (HBOT) on tooth extraction sites in rats treated with bisphosphonate. Materials and methodsRats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups: (1) 7 days of HBOT, (2) 14 days of HBOT, (3) 7-day control, and (4) 14-day control. The site of tooth extractions was analyzed by histomorphometry... περισσότερα »
Novel FGF10 mutation in autosomal dominant aplasia of lacrimal and salivary glands
Novel FGF10 mutation in autosomal dominant aplasia of lacrimal and salivary glands: Abstract ObjectiveAplasia of lacrimal and salivary glands (ALSG) is a rare autosomal dominant inherited disease, characterized by aplasia, atresia, or hypoplasia of the lacrimal and salivary systems with variable expressivity. The purpose of this study was to identify genetic etiology of an ALSG family. Materials and methodsWe recruited a Turkish family with ALSG and performed a mutational analysis, based on the candidate gene approach, to clarify the molecular genetic etiology. ResultsThe ... περισσότερα »
Blood lead concentrations as a result of retained lead pellets in the craniomaxillofacial region
in Benin City, Nigeria via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 9 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): B.E. Edetanlen, B.D. Saheeb Patients who survive gunshot wounds often retain pellets in their bodies, which cause delayed morbidity from lead poisoning, and even death. Our aim was to find out whether there is a high concentration of lead in the blood of patients who have asymptomatic retention of lead pellets in the craniomaxillofacial region. We prospectively studied 28 patients who were adm... περισσότερα »
Keystone Island Flap: Effects of Islanding on Vascularity
Keystone Island Flap: Effects of Islanding on Vascularity: [image: image]Background: Based on his clinical observations the “red dot sign” and hyperemic flare, Behan has advocated the superior vascularity of the island flap design for at least 2 decades. The aim of this study was to determine whether (1) surgical islanding of a flap alters the vascularity or blood supply of the flap and (2) these changes in blood supply explain Behan’s clinical observations of “red dot sign” and hyperemic flare. Methods: Patients undergoing local island fasciocutaneous flaps or anterolateral thigh f... περισσότερα »
The usefulness of microsurgical pedicle lengthening in free anterolateral thigh flaps
The usefulness of microsurgical pedicle lengthening in free anterolateral thigh flaps: Background A microsurgical pedicle-lengthening technique can be used when a pedicle length longer than that usually provided by an anterolateral thigh (ALT) flap is required. The purpose of this report is description of pedicle lengthening method from original pedicle length for free ALT flaps and presentation of the results of application of this technique in reconstruction from a series of cases. Patients and Methods The microsurgical pedicle-lengthening procedure was used in 10 patients who re... περισσότερα »
GSE79037 Yeast cells: Mutant M1 vs. the control with and without oxidative stress
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Contributors : Hefang Geng ; Yang Zhong ; Rongrong Jiang Series Type : Expression profiling by array Organism : Saccharomyces cerevisiae Transcription profiles of mutant M1 and the control in the absence/presence of 4mM H2O2 M1 is a mutated Saccharomyces cerevisiae strain. It was obtained through transcriptional engineering of general transcription factor TFIIB. Encoded by […]
Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Article The proteasome plays a key role in proteostasis by mediating the degradation of ubiquitinated substrates. Here the authors show that an open-gate mutant of the proteasome is hyperactive towards a subset of substrates and can effectively delay the accumulation of toxic protein aggregates. Nature Communications doi: 10.1038/ncomms10963 Authors: Won Hoon Choi, Stefanie A. H. […]
GSE79022 Tracking transcript abundance changes of D. vulgaris co-cultures with M. maripaludis in fluctuating resource environment
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Contributors : Serdar Turkarslan ; Christina E Arens ; Nitin S Baliga Series Type : Expression profiling by high throughput sequencing Organism : Desulfovibrio vulgaris str. Hildenborough Managing tradeoffs through gene regulation is believed to maintain resilience of a microbial community in a fluctuating resource environment. To investigate this hypothesis we imposed a fluctuating environment […]
Bcl-2 is a critical mediator of intestinal transformation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Article The anti-apoptotic protein Bcl-2 is selectively expressed in intestinal stem cells (ISCs). Here, the authors show that, in intestinal stem cells, Bcl-2 alleviates apoptotic priming induced by the loss of the tumour suppressor Apc in ISCs and that the absence of Bcl-2 or pharmacological blockade of Bcl-2 can inhibit the intestinal tumorigenesis driven by […]
GSE79027 Expression profiling of IL-13 stimulated PBMCs with and without an IL-13R antagonist
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Contributors : Monther Alhamdoosh ; Milica Ng ; Nicholas J Wilson ; Huy Huynh ; Michael J Wilson ; Matthew E Ritchie Series Type : Expression profiling by high throughput sequencing Organism : Homo sapiens This experiment aims to identify the biological pathways and diseases associated with the cytokine Interleukin 13 (IL-13) using gene expression […]
Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Article Functionalizing antimicrobial peptides with fluorescent groups is a useful strategy for imaging infection, but the tag can alter the performance of the probe. Here, the authors report a spacer-free method to directly functionalise an amino acid with a fluorogenic group and prepare peptide-based imaging agents for fungal infection. Nature Communications doi: 10.1038/ncomms10940 Authors: Lorena […]
Disorder-mediated crowd control in an active matter system
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Article Many living systems, such as bacterial colonies, exhibit collective and dynamic behaviours that are sensitive to the change in environmental conditions. Here, the authors show that a colloidal active matter system switches between gathering and dispersal of individuals in response to a disordered potential. Nature Communications doi: 10.1038/ncomms10907 Authors: Erçağ Pinçe, Sabareesh K. P. […]
Endoscopic Approach to Management of a Lacrimal Sac Diverticula
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Endoscopic Approach to Management of a Lacrimal Sac Diverticula: Author Information Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. Accepted for publication May 2, 2015. The author has no financial or conflicts of interest to disclose. Address correspondence and reprint requests to Mohammad Javed Ali, F.R.C.S., Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. E-mail: […]
Erratum: Pure-quartic solitons
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Erratum Nature Communications doi: 10.1038/ncomms11048 Authors: Andrea Blanco-Redondo, C. Martijn de Sterke, J. E. Sipe, Thomas F. Krauss, Benjamin J. Eggleton, Chad Husko from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/221CxRu via IFTTT
Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 38 δευτερόλεπτα
Comparison of Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair: Purpose: To compare the results of the classic Fasanella-Servat internal approach to the newer, small-incision external approach in the repair of involutional ptosis. Methods: Retrospective review identified 93 patients (104 surgical procedures) at Northwestern Ophthalmology from June 2005 until October 2011 who underwent either the […]
A Desmoplastic Melanoma Detected by an Airport Security Scanner
A Desmoplastic Melanoma Detected by an Airport Security Scanner: The diagnosis of desmoplastic melanoma is challenging for both clinicians and the histopathologists. The desmoplastic melanoma often clinically presents as a non-pigmented lesion mimicking a variety of other lesions and, as result can be mistaken for a benign non-melanocytic lesion which in-turn delays diagnosis, treatment and worsens patient prognosis. In this article we report a case of an incidental finding of desmoplastic melanoma detected by an airport security scanner.
Monitoring of Partial and Full Venous Outflow Obstruction in a Porcine Flap Model using Laser Speckle Contrast Imaging
Monitoring of Partial and Full Venous Outflow Obstruction in a Porcine Flap Model using Laser Speckle Contrast Imaging: In microsurgery, there is a demand for more reliable methods of postoperative monitoring of free flaps, especially with regard to tissue threatening obstructions of the feeding arteries and draining veins. In this study, we evaluated laser speckle contrast imaging and laser Doppler flowmetry to assess their possibilities to detect partial and full venous outflow obstruction, as well as full arterial occlusion, in a porcine flap model.
Squamous Cell Carcinoma of Medial Canthal Skin with Perineural Invasion of Orbit
Squamous Cell Carcinoma of Medial Canthal Skin with Perineural Invasion of Orbit: Mercer, Mary M.D.; Leyngold, Ilya M.D.; Margo, Curtis E. M.D., M.P.H. Free Access [image: Collapse Box]Author Information *Department of Ophthalmology, and †Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, U.S.A. Accepted for publication May 2, 2015. The authors have no financial or conflict of interest to disclose. Address correspondence and reprint requests to Curtis E. Margo, M.D., M.P.H., Department of Ophthalmology, Morsani College of Medicine... περισσότερα »
Expression analyses of splice variants of zebrafish cyclin-dependent kinase-like 5 and its substrate, amphiphysin 1
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Publication date: 25 May 2016 Source:Gene, Volume 583, Issue 1 Author(s): Syouichi Katayama, Yukako Senga, Ami Oi, Yosuke Miki, Yasunori Sugiyama, Noriyuki Sueyoshi, Isamu Kameshita Mammalian cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase mainly expressed in the central nervous system and believed to be involved in neuronal functions. However, the functions of CDKL5 […]
Identification of a variation in the IVSII of α2 gene and its frequency in the population of Guangxi
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Publication date: 25 May 2016 Source:Gene, Volume 583, Issue 1 Author(s): Wanrong Pang, Xunjin Weng, Xuehe Ye, Ju Long, Suping Wu, Lei Sun, Chunyan Wei, Mingli Chen, Weijun Tang, Shengying Qiu, Chenghong Zhang ObjectiveDuring thalassemia screening, a previously unidentified α2 gene variation in α-globin gene cluster was isolated. This variation was distinct from other variations […]
Bombyx mori cecropin A has a high antifungal activity to entomopathogenic fungus Beauveria bassiana
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Publication date: 25 May 2016 Source:Gene, Volume 583, Issue 1 Author(s): Dingding Lu, Tao Geng, Chengxiang Hou, Yuxia Huang, Guangxing Qin, Xijie Guo A cDNA encoding cecropin A (CecA) was cloned from the larvae of silkworm, Bombyx mori, using RT-PCR. It encodes a protein of 63 amino acids, containing a 22 amino acid signal peptide […]
Use of Smartphones in Telemedicine: Comparative Study Between Standard and Teledermatological Evaluation of High-Complex Care Hospital Inpatients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Telemedicine and e-Health , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UUw7hv via IFTTT
Older Adults’ Experience with a Novel Fall Detection Device
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Telemedicine and e-Health , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1nysQXM via IFTTT
Primary Care Team Members Report Greater Individual Benefits from Long- Versus Short-Term Specialty Telemedicine Mentorship
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Telemedicine and e-Health , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UUw1qq via IFTTT
Conditions of Use, Reliability, and Quality of Audio/Video-Mediated Communications During In-Home Rehabilitation Teletreatment for Postknee Arthroplasty
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Telemedicine and e-Health , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/224NP43 via IFTTT
A Study to Determine the Most Popular Lifestyle Smartphone Applications and Willingness of the Public to Share Their Personal Data for Health Research
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Telemedicine and e-Health , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/24Sbuak via IFTTT
Orbital Epithelioid Sarcoma
Orbital Epithelioid Sarcoma: A Case Report: [image: image]Epithelioid sarcoma is a rare but often aggressive malignancy of soft tissue that usually occurs in young adults as a superficial lesion in the distal upper limbs. To date, there are only 4 case reports of epithelioid sarcoma primarily occurring in the orbit. Two of these patients were treated with primary exenteration only one of whom was alive 3 years after diagnosis. Radical surgical excision is thus the first treatment of choice for primary orbital epithelioid sarcoma. The authors present a patient with primary orbital ... περισσότερα »
Intralesional Tetracycline Injection for Treatment of Lower Eyelid Festoons
Re: “Intralesional Tetracycline Injection for Treatment of Lower Eyelid Festoons”:
Cerebrospinal Fluid Leak Presenting as Epiphora
Cerebrospinal Fluid Leak Presenting as Epiphora: [image: image] A 52-year-old woman underwent a right frontotemporal craniotomy for microsurgical clip obliteration of a ruptured right dorsal variant ophthalmic segment carotid aneurysm. During the craniotomy, a defect involving the orbital roof was inadvertently created. The patient was noted postoperatively to have fluid egressing from her OD. The fluid was analyzed and based on glucose and chloride levels was determined to be cerebrospinal fluid (CSF). CT scan of the head demonstrated the orbital roof defect created during surgery... περισσότερα »
Tough to Swallow: Esophageal Food Impaction from Esophageal Amyloidosis
from #Esophageal Cancer via xlomafota13 on Inoreader http://ift.tt/1pfUvyt via IFTTT
Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa
Abstract Background Vonoprazan fumarate (TAK-438) is a novel potassium-competitive acid blocker that appears to exert a longer/more potent antisecretory effect than lansoprazole due to high accumulation/slow clearance from the gastric glands. However, there is no direct evidence that vonoprazan selectively accumulates in gastric parietal cells of gastric glands. Aim To investigate the distribution of radioactivity in the rat stomach after single intravenous administration of [3H]-labeled vonoprazan. Methods/results Autoradioluminography of the stomach revealed that at 5 h after ... περισσότερα »
New endoscopic classification of the cardiac orifice in esophageal achalasia: " Champagne glass sign"
Abstract Back ground and Aim Endoscopy, barium esophagram and manometry are used in the diagnosis of achalasia. In the case of early achalasia, characteristic endoscopic findings are difficult to recognize. As a result, the diagnosis of achalasia is often made several years after symptom onset. Therefore, we examined the endoscopic findings of the cardiac orifice in achalasia and propose a new classification. Methods A total of the 400 patients with spastic esophageal motility disorders whom underwent peroral endoscopic myotomy (POEM) at our hospital between March 2014 and Augus...περισσότερα »
Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer
Abstract Dendritic cells (DCs) are antigen-presenting cells that can acquire tumour antigens and initiate cytotoxic T cell reactions. Obesity has been proposed as a cause for tumours escaping immune surveillance, but few studies investigate the impact of other body composition parameters. We examined the relationship of DC phenotype with computer tomography (CT)-defined parameters in patients with colorectal cancer (CRC). DCs were identified within peripheral blood mononuclear cells by flow cytometry as HLA-DR positive and negative for markers of other cell lineages in 21 patients.... περισσότερα »
Important considerations in chest wall reconstruction
Chest wall reconstruction represents one of the most challenging tasks in plastic surgery. Over the past several decades, a more profound understanding of surgical anatomy and physiology along with tremendous advances in surgical technique have resulted in substantial improvements in postoperative outcomes. Conceptually, the reconstructive goals include dead space obliteration, restoration of skeletal stability with protection of intrathoracic structures, and stable soft tissue coverage. Ideally, these goals are achieved with minimal aesthetic deformity. *J. Surg. Oncol*. © 2016 ... περισσότερα »
L-LTC-IC dynamics stratify AML risk group
Acute myeloid leukemia (AML) is sustained by a subpopulation of rare leukemia-initiating cells (LICs), detectable by their capacity to self-renew and generate non-LICs in vivo. The xenograft assay captures functional properties of LICs that have clinical prognostic value, but the long duration of xenotransplantation has hampered its implementation in the clinic. Here, we describe an ex vivo co-culture system in which the frequency of leukemic long-term culture-initiating cells (L-LTC-ICs) can be used as a reliable read-out of LIC activity over one week. We analyzed 92 AML patients... περισσότερα »
polymerase {kappa} confers temozolomide resistance
The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment of human cancers, including glioblastoma (GBM). However, the molecular mechanisms by which initially chemoresponsive tumors develop therapeutic resistance remain poorly understood. In this study, we report that Pol κ, an error-prone polymerase that participates in translesion DNA synthesis, was significantly upregulated in GBM cell lines and tumor tissues following temozolomide (TMZ) treatment. Overexpression of Pol κ in TMZ-sensitive GBM cells conferred resistance to TMZ, whereas ... περισσότερα »
Quantitative phosphotyrosine profiling in leukemia xenograft
Activating mutations in tyrosine kinases (TKs) drive pediatric high-risk acute lymphoblastic leukemia (ALL) and confer resistance to standard chemotherapy. Therefore, there is urgent need to characterize dysregulated TK signaling axes in patients with ALL and identify actionable kinase targets for the development of therapeutic strategies. Here, we present the first study to quantitatively profile TK activity in xenografted patient biopsies of high-risk pediatric ALL. We integrated a quantitative phosphotyrosine profiling method with 'spike-in' stable isotope labeling with amino a... περισσότερα »
Mortalin contributes to breast cancer metastasis
Mortalin/mthsp70 (HSPA9) is a stress chaperone enriched in many cancers that has been implicated in carcinogenesis by promoting cell proliferation and survival. In the present study, we examined the clinical relevance of mortalin upregulation in carcinogenesis. Consistent with high mortalin expression in various human tumors and cell lines, we found that mortalin overexpression increased the migration and invasiveness of breast cancer cells. Expression analyses revealed that proteins involved in focal adhesion, PI3K-Akt and JAK-STAT signaling, all known to play key roles in cell m... περισσότερα »
A Case of Cushing’s Syndrome with Multiple Adrenocortical Adenomas Composed of Compact Cells and Clear Cells
Abstract A 58-year-old woman was referred to our hospital for Cushingoid features and diagnosed as adrenal Cushing's syndrome due to a right adrenocortical mass (60 × 55 mm). The mass was composed of three different tumors; the first one was homogeneously lipid-poor neoplasm measuring 20 × 13 mm located at the most dorsal region, the second one was heterogeneous and lipid-rich tumor containing multiple foci of calcification measuring 50 × 32 mm located at the central region, and the last one was heterogeneous harboring dilated and tortuous vessels and lipid-poor one measuring 35 × ...περισσότερα »
The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study
Abstract We explored the ability of local and systemic applications of boric acid (BA) to reduce the numbers of methicillin-resistant *Staphylococcus aureus* (MRSA) in a rat model of tibial osteomyelitis (OM), and compared boric acid with vancomycin (V). Implant-associated osteomyelitis was established in 35 rats. After 4 weeks, at which time OM was evident both radiologically and serologically in all animals, the rats were divided into five groups of equal number: group 1, control group (no local application of BA or other medication); group 2, V group; group 3, local BA + V group... περισσότερα »
In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells
Abstract Recently, metal nanoparticles have been getting great medical and social interests due to their potential physico-chemical properties such as higher affinity, low molecular weight, and larger surface area. The biosynthesized gold and silver nanoparticles are spherical, triangular in shape with an average size of 24–150 nm as reported in our earlier studies. The biological properties of synthesized gold and silver nanoparticles are demonstrated in this paper. The different in vitro assays such as MTT, flow cytometry, and reverse transcription polymerase chain reaction (RT-q... περισσότερα »
Progression-free survival as surrogate endpoint for overall survival in clinical trials of HER2-targeted agents in HER2-positive metastatic breast cancer
The gold standard endpoint in randomized clinical trials in metastatic breast cancer is overall survival (OS). Although therapeutics have been approved based on progression-free survival (PFS), its use as a primary endpoint is controversial. This study reports on the first individual patient data based assessment of PFS as a surrogate endpoint for OS in randomized controlled trials of anti-HER2 agents in metastatic breast cancer patients that are HER2+. We analysed the individual data from 1839 patients in 9 trials for analysis (7 first-line trials). The median survival time was 2... περισσότερα »
Trace Elements and Chemotherapy Sensitivity
Abstract Trace elements might be associated with the development of hepatocellular carcinoma (HCC) and the efficacy of chemotherapy against HCC. Therefore, this study aimed to explore the association between trace elements and efficacy of chemotherapy in patients with HCC. Cancer, cancer-adjacent, and cancer-free tissues were collected intraoperatively from 55 patients with HCC between January 2001 and April 2004 at the Affiliated Tumor Hospital of Guangxi Medical University in Guangxi (China), a high HCC incidence area in the world. Trace element levels were analyzed by atomic abs... περισσότερα »
Reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after an autologous transplant achieves durable long term disease control. An analysis from the Lymphoma Working Party Of the EBMT
A substantial fraction of patients with FL will relapse after an autoSCT and therapy for such patients remains challenging. There is currently no published study analysing the outcome of RICalloSCT exclusively in this setting. We report the outcomes for a large cohort of patients and describe how a RICalloSCT may achieve very impressive disease control albeit at the cost of significant toxicity. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1Tuz0q2 via IFTTT
Glycemic index and glycemic load and risk of colorectal cancer: a population-based cohort study (JPHC Study)
Abstract Purpose The aim of this study was for the first time to assess the association between glycemic index (GI), glycemic load (GL), and colorectal cancer using a prospective Japanese population-based cohort. Methods In our study participants aged 40–69 at baseline of the Japan Public Health Center-based prospective Study (JPHC Study) in 10 prefectural public health centers (PHC) were included. Subjects responding to the five-year follow-up survey (1995–1999) without previous history of cancer and missing data were included in the current analysis *n* = 73,501 (men *n* = 34,56...περισσότερα »
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma
Leptomeningeal metastases (LM) from melanoma has a historically poor prognosis with a median survival of about two months despite treatment. Targeted therapy and immune checkpoint inhibitors are promising new treatment options in advanced melanoma, that also can increase overall survival and may induce long lasting remission in patients with LM. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1R8lT7p via IFTTT
Targeting Hh pathway by MK-4101 in medulloblastoma and BCC
Aberrant activation of the Hedgehog (Hh) signaling pathway is implicated in the pathogenesis of many cancers, including medulloblastoma and basal cell carcinoma (BCC). In this study, using neonatally irradiated Ptch1+/- mice as a model of Hh-dependent tumors, we investigated the in vivo effects of MK-4101, a novel SMO antagonist, for treatment of medulloblastoma and BCC. Results clearly demonstrated a robust antitumor activity of MK-4101, achieved through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. Of note, beside antitumor activity on tran... περισσότερα »
Osimertinib (AZD9291) - a science-driven, collaborative approach to rapid drug design and development
Using a science-driven, collaborative approach, osimertinib (AZD9291) was designed to inhibit EGFR in a covalent irreversible manner, while harbouring preferential activity against sensitising and T790M resistance mutations, relative to the wild-type form of the receptor. The clinical development programme for osimertinib is the most rapid to date, taking just 2 years from filing the FDA Investigational New Drug Application to submitting the FDA New Drug Application and just 2 years 8 months and 1 week from the first patient dosed to the first approved indication. The development ... περισσότερα »
Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland
Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland 14 Years After En Bloc Resection of a Pleomorphic Lacrimal Gland Adenoma: [image: image] Fourteen years after en bloc resection of an orbital pleomorphic adenoma, a 61-year-old female patient developed progressive left proptosis on the same side. A CT scan revealed a round, well-circumscribed, heterogeneously enhancing mass in the lacrimal fossa of the left orbit without calcification or bone erosion. An MRI scan showed a lesion that was hypointense on T1-weighted images and heterogeneously isointense on T2-weighted images. T...περισσότερα »
Incidental finding of cutaneous meningeal heterotopia in aplasia cutis congenita_R1
Abstract Aplasia cutis congenita and cutaneous meningeal heterotopia are both rare congenital conditions that most commonly occur on the scalp and may appear clinically and histologically similar. A subtype of aplasia cutis congenita, membranous aplasia cutis congenita, and cutaneous meningeal heterotopia are both proposed to result from neural tube closure errors. However, neither non-membranous nor membranous aplasia cutis congenita are known to occur together with cutaneous meningeal heterotopia in the same lesion. We report the incidental finding of cutaneous meningeal heteroto...περισσότερα »
Cutaneous Metastasis of Breast Adenoid Cystic Carcinoma to the Scalp
Abstract Adenoid cystic carcinoma is a tumor that can be of primary cutaneous origin or secondary to metastatic disease, most commonly salivary origin. Aside from primary cutaneous and salivary types, adenoid cystic carcinoma of the breast is a rare, more indolent variant. Cutaneous metastases secondary to breast adenoid cystic carcinoma is exceedingly uncommon and not previously reported to our knowledge. We present the case of a 67 year- old woman who developed cutaneous metastasis from primary breast adenoid cystic carcinoma. from Anatomy Pathology via ola Kala on Inoreader htt... περισσότερα »
Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma
Abstract Background Cutaneous lymphadenoma (CL) is rare neoplasm that clinically and histologically resembles basal cell carcinoma (BCC). CL, composed of dermal basaloid epithelial islands with prominent admixed lymphocytes, characteristically contains CK20-positive Merkel cells.. However, CK20 may be of limited use due to low Merkel cell density in small samples. CK17 is expressed diffusely throughout BCC. We investigated the discriminatory utility of CK17 and CK20 in CL and BCC. Methods A retrospective clinicopathological review of 11 cases of CL and 14 BCC was performed. CK20...περισσότερα »
Use of the frozen section “jelly-roll” technique to aid in the diagnosis of bullous congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis)
Abstract Frozen section is a valuable tool that is often underutilized in the setting of in-patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma /epidermolytic hyperkeratosis and epidermolysis bullosa. A thin de... περισσότερα »
Cutaneous Presentation of Disseminated Histoplasmosis as a Solitary Peri-anal Ulcer. Case Report and Discussion
Abstract Disseminated histoplasmosis has a diverse and non-specific range of clinical signs and symptoms. In a significant minority of patients, cutaneous lesions are apparent at the time of initial presentation, affording an opportunity to establish the diagnosis from a skin biopsy. The most frequently reported clinical scenario in immunocompromised patients with cutaneous involvement is that of multiple papulo-nodular lesions on the face, trunk or extremities. The following report features an immunocompetent patient who presented with a solitary ulcerated plaque on the buttocks ... περισσότερα »
Issue Information - TOC
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Issue Information - Ed Board
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Ocular Adnexal Acne Agminata
Ocular Adnexal Acne Agminata: Histopathological and Clinical Case Series: [image: image]Purpose: Acne agminata has only been rarely reported in the ocular adnexa. This study was undertaken to identify histopathological, clinical, and management features of this disorder. Methods: A computerized database was utilized to identify cases of ocular adnexal acne agminata. Via chart review and light microscopy, clinical and histopathologic aspects of this dermatosis were collected, and statistical analyses were performed. Results: Twelve cases (5 males, 7 females, mean age = 50.5 years) of...περισσότερα »
Hypertension Prevalence, Awareness, Treatment, and Control Following Chinas Healthcare Reform
BACKGROUND In 2009, China started an impressive national healthcare system reform. One of the key components is to promote equity in access to essential healthcare services including chronic disease management. We assessed the changes in hypertension management and its equity before and after China's healthcare reform in 2009. METHODS We used data from the 2008 and 2012 waves of the China Health and Retirement Longitudinal Study (CHARLS). The surveys were conducted in Zhejiang and Gansu provinces, containing 1,961 and 1,836 respondents aged 45 and older in 2008 and 2012 respect... περισσότερα »
Editorial_Board
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The Role of Aldosterone in Obesity-Related Hypertension
Obese subjects often have hypertension and related cardiovascular and renal diseases, and this has become a serious worldwide health problem. In obese subjects, impaired renal-pressure natriuresis causes sodium retention, leading to the development of salt-sensitive hypertension. Physical compression of the kidneys by visceral fat and activation of the sympathetic nervous system, renin–angiotensin systems (RAS), and aldosterone/mineralocorticoid receptor (MR) system are involved in this mechanism. Obese subjects often exhibit hyperaldosteronism, with increased salt sensitivity of ...περισσότερα »
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Obstructive sleep apnoea: patients' experiences of oral appliance treatment
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Summary Over the past few decades, there has been a pronounced increase in the number of patients being treated by general dental practitioners for obstructive sleep apnoea (OSA). The purpose of this study was to survey the care and patient experiences and the self-reported effectiveness of OSA treatment with an oral appliance (OA) incorporating mandibular advancement. The design was a retrospective, cross-sectional study, with follow-up between 6 months to 1 year after commencement of treatment. A survey form was posted to 1150 subjects, identified in the regional register over a ...περισσότερα »
Olaparib monotherapy in patients with advanced relapsed ovarian cancer and a germline BRCA1/2 mutation: a multi-study analysis of response rates and safety
These pooled data from six trials of olaparib monotherapy (400 mg bid capsule) in patients with relapsed ovarian cancer and a germline *BRCA1/2* mutation show that patients who had received ≥3 lines of prior chemotherapy had a similar safety profile and clinical benefit to the overall pooled patient population, with a similar response rate (31% vs 36%) and durable responses (7.8 vs 7.4 months). from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1TuyZlP via IFTTT
Oligoesculin fraction induces anti-tumor effects and promotes immune responses on B16-F10 mice melanoma
Abstract Laccase was used to enzymatically polymerize esculin. Oligoesculin fraction was obtained after ultrafiltration through a 5-kDa membrane. Several studies have been carried out to prove the effectiveness of natural substances such as immunomodulators to promote the anti-cancer activity in situ. The purpose of our report was to explore whether the anti-tumor potential of the oligoesculin fraction in vitro and in vivo is linked to its immunological mechanisms in melanoma-bearing mice. We revealed that oligoesculin fraction reduced B16-F10 proliferation and migration in vitro ... περισσότερα »
Effects of neuromuscular electrical stimulation combined with effortful swallowing on post-stroke oropharyngeal dysphagia: a randomised controlled trial
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Summary Neuromuscular electrical stimulation (NMES) has been used as a therapeutic intervention for dysphagia. However, the therapeutic effects of NMES lack supporting evidence. In recent years, NMES combined with traditional swallowing therapy has been used to improve functional recovery in patients with post-stroke dysphagia. This study aimed to investigate the effects of effortful swallowing combined with neuromuscular electrical stimulation on hyoid bone movement and swallowing function in stroke patients. Fifty stroke patients with mild dysphagia who were able to swallow again...περισσότερα »
Choosing the best image processing method for masticatory performance assessment when using two-coloured specimens
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Summary Objective masticatory performance assessment using two-coloured specimens relies on image processing techniques; however, just a few approaches have been tested and no comparative studies are reported. The aim of this study was to present a selection procedure of the optimal image analysis method for masticatory performance assessment with a given two-coloured chewing gum. Dentate participants (*n* = 250; 25 ± 6·3 years) chewed red-white chewing gums for 3, 6, 9, 12, 15, 18, 21 and 25 cycles (2000 samples). Digitalised images of retrieved specimens were analysed using 122 i...περισσότερα »
Contrasting exome constancy and regulatory region variation in the gene encoding CYP3A4: an examination of the extent and potential implications.
Objective: CYP3A4 expression varies up to 100-fold among individuals, and, to date, genetic causes remain elusive. As a major drug-metabolizing enzyme, elucidation of such genetic causes would increase the potential for introducing personalized dose adjustment of therapies involving CYP3A4 drug substrates. The foetal CYP3A isoform, CYP3A7, is reported to be expressed in ~10% of European adults and may thus contribute towards the metabolism of endogenous substances and CYP3A drug substrates. However, little is known about the distribution of the variant expressed in the adult. Method... περισσότερα »
Combination of the MEK inhibitor pimasertib with BTK or PI3K-delta inhibitors is active in pre-clinical models of aggressive lymphomas
The B-cell receptor with its downstream signaling pathways is an important therapeutic target for B-cell lymphomas. Here, we present pre-clinical evidences of the synergism of combining the MEK1/2 inhibitor pimasertib with the BTK inhibitor ibrutinib or with the PI3K-delta inhibitor idelalisib, providing the rational for clinical trials exploring these combinations in patients with lymphomas. from #Oncology via alexandrossfakianakis on Inoreader http://ift.tt/1M7Xttx via IFTTT
PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells
Abstract Prostate cancer antigen 3 (PCA3) is a prostate-specific long noncoding RNA (lncRNA) involved in the control of prostate cancer (PCa) cell survival, through modulating androgen receptor (AR) signaling. To further comprehend the mechanisms by which PCA3 modulates LNCaP cell survival, we characterized the expression patterns of several cancer-related genes, including those involved in epithelial-mesenchymal transition (EMT) and AR cofactors in response to PCA3 silencing. We also aimed to develop a strategy to stably silence PCA3. Small interfering RNA (siRNA) or short hairpi...περισσότερα »
M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma
Background Myxoma virus (MYXV) is a promising oncolytic agent and is highly effective against immortalized glioma cells but less effective against brain tumor initiating cells (BTICs), which are believed to mediate glioma development/recurrence. MYXV encodes various proteins to attenuate host cell apoptosis, including an antiapoptotic Bcl-2 homologue known as M011L. Such proteins may limit the ability of MYXV to kill BTICs, which have heightened resistance to apoptosis. We hypothesized that infecting BTICs with an M011L-deficient MYXV construct would overcome BTIC resistance to ...περισσότερα »
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from Cancer via ola Kala on Inoreader http://ift.tt/1UgF4B9 via IFTTT
Table_of_Contents
from Cancer via ola Kala on Inoreader http://ift.tt/1QFhLi1 via IFTTT
One-Stage Alternatives to the Hughes Procedure for Reconstruction of Large Lower Eyelid Defects: Surgical Techniques and Outcomes
One-Stage Alternatives to the Hughes Procedure for Reconstruction of Large Lower Eyelid Defects: Surgical Techniques and Outcomes: [image: image] Purpose: To present the results of 1-stage surgical advancement flaps for the repair of large full thickness lower eyelid defects. These avoid the disadvantages of the 2-stage Hughes procedure and provide favorable functional and aesthetic outcomes. Methods: A retrospective case series of 36 lower eyelid repairs performed on 31 patients by a single surgeon in Sydney, Australia is presented. The selection criterion was a horizontal defect ... περισσότερα »
Novel SDHB and TMEM127 Mutations in Patients with Pheochromocytoma/Paraganglioma Syndrome
Abstract Pheochromocytomas (Pheo) and paragangliomas (PGL) are rare tumors, with heterogeneous genetic background. In up to 30 % of all, apparently sporadic Pheo/PGL cases germline mutations can be identified in one of the 15 genes representing genetic susceptibility for Pheo/PGL. Malignancy is rare but it frequently associates with *SDHB* mutations. Our aim was to determine the prevalence of germline *SDHx*, *SDHAF2*, *MAX* and *TMEM127* mutations in Hungarian patients with apparently sporadic Pheo/PGLs. Mutation screening of the *SDHx*, *SDHAF2*, *MAX* and *TMEM127* genes was per... περισσότερα »
Keratomycosis caused by Blastoschizomyces capitatus
*Susanta Kumar Sahu, Jayashree Dora, Gopeswari Hota* Indian Journal of Pathology and Microbiology 2016 59(1):117-118 Keratomycosis or fungal infections of cornea are common causes of ocular morbidity particularly in developing countries and in tropical climate. Traumatic inoculation is the predominant predisposing factor for this condition. Most of the cases are caused by filamentous fungi. Blastoschizomyces capitatus is one of the emerging fungal agents causing infection in different organ systems particularly in immunocompromised individuals. Barring one case of keratitis and melt...περισσότερα »
The revised guidelines of the medical council of India for academic promotions: Need for a rethink
*Rakesh Aggarwal, Nithya Gogtay, Rajeev Kumar, Peush Sahni, for the Indian Association of Medical Journal Editors* Indian Journal of Pathology and Microbiology 2016 59(1):2-5 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1LSiFc1 via IFTTT
Incidental finding of cutaneous meningeal heterotopia in aplasia cutis congenita_R1
Abstract Aplasia cutis congenita and cutaneous meningeal heterotopia are both rare congenital conditions that most commonly occur on the scalp and may appear clinically and histologically similar. A subtype of aplasia cutis congenita, membranous aplasia cutis congenita, and cutaneous meningeal heterotopia are both proposed to result from neural tube closure errors. However, neither non-membranous nor membranous aplasia cutis congenita are known to occur together with cutaneous meningeal heterotopia in the same lesion. We report the incidental finding of cutaneous meningeal heteroto...περισσότερα »
Cutaneous Metastasis of Breast Adenoid Cystic Carcinoma to the Scalp
Abstract Adenoid cystic carcinoma is a tumor that can be of primary cutaneous origin or secondary to metastatic disease, most commonly salivary origin. Aside from primary cutaneous and salivary types, adenoid cystic carcinoma of the breast is a rare, more indolent variant. Cutaneous metastases secondary to breast adenoid cystic carcinoma is exceedingly uncommon and not previously reported to our knowledge. We present the case of a 67 year- old woman who developed cutaneous metastasis from primary breast adenoid cystic carcinoma. from #Dermatology via alexandrossfakianakis on Inore... περισσότερα »
Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma
Abstract Background Cutaneous lymphadenoma (CL) is rare neoplasm that clinically and histologically resembles basal cell carcinoma (BCC). CL, composed of dermal basaloid epithelial islands with prominent admixed lymphocytes, characteristically contains CK20-positive Merkel cells.. However, CK20 may be of limited use due to low Merkel cell density in small samples. CK17 is expressed diffusely throughout BCC. We investigated the discriminatory utility of CK17 and CK20 in CL and BCC. Methods A retrospective clinicopathological review of 11 cases of CL and 14 BCC was performed. CK20...περισσότερα »
Use of the frozen section “jelly-roll” technique to aid in the diagnosis of bullous congenital ichthyosiform erythroderma (epidermolytic hyperkeratosis)
Abstract Frozen section is a valuable tool that is often underutilized in the setting of in-patient dermatology. Traditionally, frozen section has been used in dermatology to diagnose toxic epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period. We report a newborn female with ruptured bullae on the face, chest, back and extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma /epidermolytic hyperkeratosis and epidermolysis bullosa. A thin de... περισσότερα »
Cutaneous Presentation of Disseminated Histoplasmosis as a Solitary Peri-anal Ulcer. Case Report and Discussion
Abstract Disseminated histoplasmosis has a diverse and non-specific range of clinical signs and symptoms. In a significant minority of patients, cutaneous lesions are apparent at the time of initial presentation, affording an opportunity to establish the diagnosis from a skin biopsy. The most frequently reported clinical scenario in immunocompromised patients with cutaneous involvement is that of multiple papulo-nodular lesions on the face, trunk or extremities. The following report features an immunocompetent patient who presented with a solitary ulcerated plaque on the buttocks ... περισσότερα »
Treating buccinator synkinesis with botulinum toxin
Treating Buccinator With Botulinum Toxin in Patients With Facial Synkinesis: A Previously Overlooked Target: [image: image] Objective: Synkinesis after facial nerve injury produces functional and cosmetic concerns for patients. The purpose of this study was to review the authors’ experience of treating buccinator synkinesis with botulinum toxin. Methods: This was a retrospective medical records review. All patients seen at the University of Wisconsin Neuromuscular Retraining Clinic who were treated with botulinum injections to the buccinator muscle were included. After a period of ... περισσότερα »
Contrasting exome constancy and regulatory region variation in the gene encoding CYP3A4: an examination of the extent and potential implications.
Objective: CYP3A4 expression varies up to 100-fold among individuals, and, to date, genetic causes remain elusive. As a major drug-metabolizing enzyme, elucidation of such genetic causes would increase the potential for introducing personalized dose adjustment of therapies involving CYP3A4 drug substrates. The foetal CYP3A isoform, CYP3A7, is reported to be expressed in ~10% of European adults and may thus contribute towards the metabolism of endogenous substances and CYP3A drug substrates. However, little is known about the distribution of the variant expressed in the adult. Method... περισσότερα »
Production of CCL20 from lung cancer cells induces the cell migration and proliferation through PI3K pathway
Abstract Tumour inflammatory microenvironment is considered to play a role in the sensitivity of tumour cells to therapies and prognosis of patients with lung cancer. The expression of CCL20, one of the critical chemoattractants responsible for inflammation cells recruitment, has been shown overexpressed in variety of tumours. This study aimed at investigating potential mechanisms of CCL20 function and production in human non-small cell lung cancer (NSCLC). Expression of CCL20 gene and protein in lung tissues of patients with NSCLC and NSCLC cells (A549) were determined. The inter...περισσότερα »
Iatrogenic immunodeficiency-associated lymphoproliferative disorders in transplant and nontransplant settings
*Matthew G.S. Kubica, Nikhil A Sangle* Indian Journal of Pathology and Microbiology 2016 59(1):6-15 Iatrogenic immunodeficiency-associated lymphoproliferative disorders comprise a group of lymphoid neoplasms that are associated with an immunosuppressed state, either in the posttransplant period, or during the treatment of various autoimmune and rheumatologic disorders by immunomodulatory medications. Their morphologies vary widely but are generally classified according to the lymphomas that they most closely resemble. This group is strongly associated with infections by the Epstein... περισσότερα »
Myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable; rare cause of granulocytic sarcoma: A diagnostic dilemma
*Prakas Kumar Mandal, Meet Kumar, Maitreyee Bhattyacharyya* Indian Journal of Pathology and Microbiology 2016 59(1):133-134 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1R88rAh via IFTTT
Panniculitis is a common unrecognized histopathological feature of cutaneous leishmaniasis
*Khalifa E Sharquie, Ammar F Hameed, Adil A Noaimi* Indian Journal of Pathology and Microbiology 2016 59(1):16-19 Background: Cutaneous leishmaniasis (CL) is a parasitic cutaneous infection caused by Leishmania parasite. The histopathology is usually granulomatous in nature. Aims: The aim of the present study is to elucidate the histology of CL and evaluate the presence and the frequency of panniculitis among the affected patients. Settings and Design: Case series interventional study. Materials and Methods: Thirty-five patients with CL were diagnosed clinically between December-201...περισσότερα »
Acute monoblastic leukemia with abnormal eosinophils and inversion (16): A rare entity
*Kiruthiga Kala Gnanasekaran, Mary P Chacko, Marie Therese Manipadam, MS Bindra, Biju George, Vivi M Srivastava* Indian Journal of Pathology and Microbiology 2016 59(1):104-106 Acute myeloid leukemia (AML) is a malignant hematopoietic stem cell disorder which is sub-classified based on bone marrow morphology and the presence of specific genetic abnormalities. One such cytogenetic abnormality is the pericentric inversion (inv) of chromosome 16 which is typically seen in AML M4 with eosinophilia and is associated with a favorable prognosis. We report the inv (16) in a young woman with... περισσότερα »
A clinicopathological study of mediastinal masses operated in a tertiary care hospital in Eastern India in 3 years with special reference to thymoma
*Senjuti Dasgupta, Debdas Bose, Nirmal Kumar Bhattacharyya, Maitrayee Saha, Keya Biswas, Pranab Kumar Biswas* Indian Journal of Pathology and Microbiology 2016 59(1):20-24 Introduction: The mediastinum is the central portion of the thoracic cavity, limited by pleural cavities laterally, thoracic inlet superiorly, and the diaphragm inferiorly. Housing numerous organs, it is a veritable Pandora's box, within which various lesions may develop. This study was conducted to assess the epidemiologic profile, clinicoradiological features, cytological, and histopathological findings in patie... περισσότερα »
Pregnancy-like hyperplasia and cystic hypersecretory changes adjacent to metaplastic carcinoma of the breast
*Canan Kelten, Ceren Boyaci, Cem Leblebici, Didem Can Trabulus, Mehmet Ali Nazli* Indian Journal of Pathology and Microbiology 2016 59(1):126-127 from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1R88oEL via IFTTT
Clinico-histopathological study of varicose vein and role of matrix metalloproteinases-1, matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinase-1 in varicose vein formation
*Bitan Naik, Mohan Kumar, Ajay Kumar Khanna, Pradeep Kumar Suman* Indian Journal of Pathology and Microbiology 2016 59(1):25-30 Background and Aims: Varicose vein (VV) is an important cause of morbidity in the young and elderly population. Many studies of the Western country suggest that matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs have a crucial role in the pathogenesis of VV, but limited work has been done in Indian population. The aim of this study is to study detailed histology of VV and to see the expression of MMP-1, MMP-9 and tissue inhibitor of matrix metal... περισσότερα »
Primary endobronchial myxoid leiomyoma in a child: An unusual case report and review of literature
*Ashutosh Awasthi, Suparna Dubey, Abha K Sabhikhi, Sabyasachi Bal* Indian Journal of Pathology and Microbiology 2016 59(1):87-89 Primary leiomyomas are rare benign tumors of the lung and only 25 cases have been documented in children, most of which are endobronchial. Leiomyomas are benign smooth muscle neoplasms, usually diagnosed on morphological characteristics. However, immunohistochemistry plays a crucial role in the lineage differentiation when these are encountered at unusual sites or with unexpected morphological features. We report a case of endobronchial tumor of a 13-year-... περισσότερα »
Kaleidoscope of oral artifacts: A vivid picture through light and polarizing microscope
*Priyanka Kardam, Kanu Jain, Monica Mehendiratta, Yulia Mathias* Indian Journal of Pathology and Microbiology 2016 59(1):31-34 Background: This study is based on finding of an inexplicable artifact that was seen in the tissue received as periapical granuloma. Aim: To observe the histological appearance of different commonly implanted food particles and easily incorporated substances from a laboratory in the oral biopsy tissues. Materials and Methods: Various food particles such as wheat chapatti, beans, peas, pulses, and coriander leaves and substances such as a suture, cotton, and ... περισσότερα »
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates. Common causes are mechanical trauma and cast immobilization, as well as multiple drugs such as retinoids and antineoplastic agents. However, the development of pyogenic granuloma under treatment with encorafenib (LGX818) has not yet been reported. These three cases might be ...περισσότερα »
The Self-Reported Use of Immunostains and Cytogenetic Testing in the Diagnosis of Melanoma by Practicing U.S. Pathologists of 10 Selected States
Abstract Background The diagnosis of melanoma can be challenging, especially in lesions for which the histopathologic criteria bridge two or more taxonomic categories. Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) have been introduced as ancillary techniques to differentiate benign and malignant melanocytic proliferations. Methods We evaluated how pathologists perceive and are incorporating these new cytogenetic testing technologies into their practices. We conducted a study of 207 U.S. pathologists who ... περισσότερα »
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates. Common causes are mechanical trauma and cast immobilization, as well as multiple drugs such as retinoids and antineoplastic agents. However, the development of pyogenic granuloma under treatment with encorafenib (LGX818) has not yet been reported. These three cases might be ...περισσότερα »
The Self-Reported Use of Immunostains and Cytogenetic Testing in the Diagnosis of Melanoma by Practicing U.S. Pathologists of 10 Selected States
Abstract Background The diagnosis of melanoma can be challenging, especially in lesions for which the histopathologic criteria bridge two or more taxonomic categories. Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) have been introduced as ancillary techniques to differentiate benign and malignant melanocytic proliferations. Methods We evaluated how pathologists perceive and are incorporating these new cytogenetic testing technologies into their practices. We conducted a study of 207 U.S. pathologists who ... περισσότερα »
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates. Common causes are mechanical trauma and cast immobilization, as well as multiple drugs such as retinoids and antineoplastic agents. However, the development of pyogenic granuloma under treatment with encorafenib (LGX818) has not yet been reported. These three cases might be ...περισσότερα »
The Self-Reported Use of Immunostains and Cytogenetic Testing in the Diagnosis of Melanoma by Practicing U.S. Pathologists of 10 Selected States
Abstract Background The diagnosis of melanoma can be challenging, especially in lesions for which the histopathologic criteria bridge two or more taxonomic categories. Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) have been introduced as ancillary techniques to differentiate benign and malignant melanocytic proliferations. Methods We evaluated how pathologists perceive and are incorporating these new cytogenetic testing technologies into their practices. We conducted a study of 207 U.S. pathologists who ... περισσότερα »
Treatment of Hemifacial Spasm With OnabotulinumtoxinA
Subjective and Objective Measures in the Treatment of Hemifacial Spasm With OnabotulinumtoxinA: Abstract Purpose: To evaluate the Sunnybrook Facial Grading System (SFGS) and Facial Clinimetric Evaluation (FaCE) Scale Instrument outcomes when treating hemifacial spasm (HFS) with onabotulinumtoxinA. Methods: An Institutional Review Board–approved retrospective review of records of 66 HFS patients treated with onabotulinumtoxinA. SFGS and FaCE surveys were completed prior to onabotulinumtoxinA therapy and at 1 month follow up. Surveys were analyzed for differences using paired Stude... περισσότερα »
Engorgement of the Angular and Temporal Veins Following Periorbital Hyaluronic Acid Gel Injection
Engorgement of the Angular and Temporal Veins Following Periorbital Hyaluronic Acid Gel Injection: [image: image]Purpose: To study angular and temporal vein engorgement following periorbital hyaluronic acid gel (HAG) injection. Methods: In this retrospective study, the authors reviewed the photographs of 805 patients who had periorbital HAG injection at Jules Stein Eye Institute Oculoplastic Clinic between January 2004 and January 2014. HAG injections were used to fill the orbital hollow, zygomatic hollow, septal confluence hollow, and cheek. The inclusion criteria were patients who...περισσότερα »
Editorial_Board
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UgF4B9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Table_of_Contents
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QFhLi1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
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alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QFhNXc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives To investigate the contribution of ultra-processed foods to the intake of added sugars in the USA. Ultra-processed foods were defined as industrial formulations which, besides salt, sugar, oils and fats, include substances not used in culinary preparations, in particular additives used to imitate sensorial qualities of minimally processed foods and their culinary preparations. Design […]
Assessing comorbidity and correlates of wasting and stunting among children in Somalia using cross-sectional household surveys: 2007 to 2010
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective Wasting and stunting may occur together at the individual child level; however, their shared geographic distribution and correlates remain unexplored. Understanding shared and separate correlates may inform interventions. We aimed to assess the spatial codistribution of wasting, stunting and underweight and investigate their shared correlates among children aged 6–59 months in Somalia. Setting Cross-sectional […]
Assessing the appropriateness of prevention and management of venous thromboembolism in Australia: a cross-sectional study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The prevention and management of venous thromboembolism (VTE) is often at variance with guidelines. The CareTrack Australia (CTA) study reported that appropriate care (in line with evidence-based or consensus-based guidelines) is being provided for VTE at just over half of eligible encounters. The aim of this paper is to present and discuss the detailed […]
Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction Total glucosides of paeony (TGP) is a natural plant extract, which is widely used in China for treating rheumatoid arthritis (RA). Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. This systematic review aims to examine the effectiveness and safety of TGP in patients […]
Why is there variation in the practice of evidence-based medicine in primary care? A qualitative study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective To explore the factors, including barriers and facilitators, influencing the practice of evidence-based medicine (EBM) across various primary care settings in Malaysia based on the doctors’ views and experiences. Research design The qualitative study was used to answer the research question. 37 primary care physicians participated in six focus group discussions and six individual […]
Inflammation: friend or foe? – Asianjournal.com
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Inflammation: friend or foe? Asianjournal.com Chronic (long-term) inflammation in the body — like dental carries, eczema, infection of the ear, nose, sinuses, nail, skin, stomach, colon, or any tissue or organ inside our body — could lead to major killer diseases of our time, including cancer … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1LSHO6o via […]
Supreme Court sceptical of claims that smoking kills; seeks … – Economic Times
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Supreme Court sceptical of claims that smoking kills; seeks … Economic Times NEW DELHI: The Supreme Court on Tuesday was openly sceptical of claims that smoking causes cancer, but demanded answers from the central government … Now cigarettes under Supreme Court scanner – BUREAUCRACY …Bureaucracy Today all 2 news articles » from #ORL-AlexandrosSfakianakis via simeraentaxei […]
The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
MicroRNAs (miRNAs) play important roles in modulating the neoplastic process of cancers including head and neck squamous cell carcinoma (HNSCC). A genetic polymorphism (rs2292832, C>T) has been recently identified in the precursor of *miR-149*; nevertheless its clinicopathological implications remain obscure. In this study, we showed that *miR-149* is down-regulated in HNSCC compared to normal mucosa and this is associated with a poorer patient survival. In addition, HNSCC patients with the T/T genotype have more advanced tumors and a worse prognosis. Multivariate analysis indicate... περισσότερα »
Normoxic accumulation of HIF1α is associated with glutaminolysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Objectives The stabilization of the transcription factor and prognostic tumor marker hypoxia-inducible factor 1α (HIF1α) is considered to be crucial for cellular metabolic adaptations to hypoxia. However, HIF1α has also been shown to accumulate under normoxic conditions, although this phenomenon is poorly understood. Methods We investigated the conditions for normoxic HIF1α stabilization in different tumor cell lines (e.g., two mammary carcinoma cell lines and three oral squamous cell carcinoma cell lines) via Western blot analysis or immunohistochemical staining. The tr... περισσότερα »
Cell Growth Dynamics in Embryonic and Adult Mouse Thyroid Revealed by a Novel Approach to Detect Thyroid Gland Subpopulations
Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/1RShCYX via IFTTT
Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis
[image: access_no.gif] Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/221wbla via IFTTT
Nitroglycerin Ointment in Ischemic Vascular Filler Complications
Rethinking the Role of Nitroglycerin Ointment in Ischemic Vascular Filler Complications: An Animal Model With ICG Imaging: [image: image]Purpose: Soft tissue dermal fillers, both temporary and permanent, are used frequently in facial rejuvenation. As the use of fillers increases, ischemic complications including skin necrosis are becoming more prevalent. In the literature, topical nitroglycerin paste has been recommended in the early treatment of patients presenting with ischemia. The purpose of this study was to evaluate the vascular perfusion effects of topical nitroglycerin pas... περισσότερα »
Novel Pigtail Cannula for a Canalicular-Involving Eyelid Laceration
Novel Pigtail Cannula for a Canalicular-Involving Eyelid Laceration: [image: image] An 89-year-old woman presented with a canalicular-involving laceration/avulsion of the right lower eyelid after a fall. The inferior canaliculus was severed deep within the wound, and the ends were difficult to identify. Novel pigtail cannulas, designed by the authors, were used for lacrimal system intubation and suture passage. Satisfactory cosmetic and functional results were achieved. These cannulas facilitate repair by integrating multiple functionalities in a single instrument. Once a cannula h... περισσότερα »
Use of Direct Otoscope for Intranasal Examination After Dacryocystorhinostomy
Use of Direct Otoscope for Intranasal Examination After Dacryocystorhinostomy: [image: image] Purpose: To evaluate whether the use of a direct otoscope in the nose is an effective method to observe the nasolacrimal anastomosis site after dacryocystorhinostomy. Methods: In 75 eyes undergoing external dacryocystorhinostomy, the lacrimal irrigation test was performed and fluorescein solution was instilled in the conjunctival sac. After applying topical anesthetics and decongestant, a direct otoscope was inserted in the middle meatus and directed toward the medial canthus. Results: I... περισσότερα »
Orbital Relapsing Polychondritis
Orbital Relapsing Polychondritis: A Unique Presentation, Complication, and Treatment: [image: image]An 87-year-old man with a history of relapsing polychondritis presented to the emergency department after 4 days of worsening left periorbital swelling and erythema. On examination, he demonstrated clinical features consistent with orbital cellulitis and was treated with a trial of intravenous antibiotics. His condition did not improve over the next 36 hours and intravenous methylprednisolone was initiated. This led to rapid improvement in orbital symptoms and signs, and a diagnosis o...περισσότερα »
Erratum: Pure-quartic solitons
Erratum Nature Communications doi: 10.1038/ncomms11048 Authors: Andrea Blanco-Redondo, C. Martijn de Sterke, J. E. Sipe, Thomas F. Krauss, Benjamin J. Eggleton, Chad Husko from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/221CxRu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QFtJYZ via IFTTT
A Study to Determine the Most Popular Lifestyle Smartphone Applications and Willingness of the Public to Share Their Personal Data for Health Research
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Direct to Consumer Mobile Teledermatology Apps: An Exploratory Study
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Endoscopic Approach to Management of a Lacrimal Sac Diverticula
Endoscopic Approach to Management of a Lacrimal Sac Diverticula: Author Information Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. Accepted for publication May 2, 2015. The author has no financial or conflicts of interest to disclose. Address correspondence and reprint requests to Mohammad Javed Ali, F.R.C.S., Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. E-mail:… Continue reading Endoscopic Approach to Management of a Lacrimal Sac Diverticula
Genetic epidemiology of migraine and depression
Background Migraine and major depressive disorder (commonly referred to as depression) are both common disorders with a significant impact on society. Studies in both clinical and community-based settings have demonstrated a strong relationship between migraine and depression. In addition to complicating the diagnosis, depression that is comorbid with migraine may lower treatment adherence, increase risk… Continue reading Genetic epidemiology of migraine and depression
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Article Here, Richa Saxena and colleagues perform a genome-wide association study (GWAS) of self-reported morningness/eveningness preference in the UKBiobank cohort, and identify new genetic loci that contribute to a person’s chronotype. Nature Communications doi: 10.1038/ncomms10889 Authors: Jacqueline M. Lane, Irma Vlasac, Simon G. Anderson, Simon D. Kyle, William G. Dixon, David A. Bechtold, Shubhroz Gill,… Continue reading Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
L-LTC-IC dynamics stratify AML risk group
Acute myeloid leukemia (AML) is sustained by a subpopulation of rare leukemia-initiating cells (LICs), detectable by their capacity to self-renew and generate non-LICs in vivo. The xenograft assay captures functional properties of LICs that have clinical prognostic value, but the long duration of xenotransplantation has hampered its implementation in the clinic. Here, we describe an… Continue reading L-LTC-IC dynamics stratify AML risk group
Eyelid Dermal Keratinous Cysts of Pilosebaceous Origin
Unusual Eyelid Dermal Keratinous Cysts of Pilosebaceous Origin: Purpose: To describe 2 types of previously unrecognized dermal keratinous cysts of the eyelids—2 single sebaceous duct cysts derived from the glands of Zeis and 2 cases of multiple eruptive vellus hair cysts, both types associated with the pilosebaceous apparatus. Methods: Clinical records and paraffin sections subjected… Continue reading Eyelid Dermal Keratinous Cysts of Pilosebaceous Origin
polymerase {kappa} confers temozolomide resistance
The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment of human cancers, including glioblastoma (GBM). However, the molecular mechanisms by which initially chemoresponsive tumors develop therapeutic resistance remain poorly understood. In this study, we report that Pol κ, an error-prone polymerase that participates in translesion DNA synthesis, was significantly upregulated… Continue reading polymerase {kappa} confers temozolomide resistance
Quantitative phosphotyrosine profiling in leukemia xenograft
Activating mutations in tyrosine kinases (TKs) drive pediatric high-risk acute lymphoblastic leukemia (ALL) and confer resistance to standard chemotherapy. Therefore, there is urgent need to characterize dysregulated TK signaling axes in patients with ALL and identify actionable kinase targets for the development of therapeutic strategies. Here, we present the first study to quantitatively profile TK… Continue reading Quantitative phosphotyrosine profiling in leukemia xenograft
Proprioceptive Phenomenon With Involutional Ptosis: Evidential Findings in Anophthalmic Ptosis
Proprioceptive Phenomenon With Involutional Ptosis: Evidential Findings in Anophthalmic Ptosis: [image: image]Purpose: To determine the effect of ptosis on compensatory frontalis contraction in patients without visual input and to identify if a sensory stimulus contributes to brow elevation. Methods: A prospective study. Clinical photographs were measured by 2 masked oculoplastic surgeons to determine brow height in 8 patients with unilateral ocular prosthesis in 3 conditions: at baseline, after a gold weight was applied to the upper eyelid inducing acute ptosis, and with the gold w... περισσότερα »
Axial Globe Position Measurement: A Prospective Multicenter Study by the International Thyroid Eye Disease Society
Axial Globe Position Measurement: A Prospective Multicenter Study by the International Thyroid Eye Disease Society: [image: image]Purpose: Identify a reproducible measure of axial globe position (AGP) for multicenter studies on patients with thyroid eye disease (TED). Methods: This is a prospective, international, multicenter, observational study in which 3 types of AGP evaluation were examined: radiologic, clinical, and photographic. In this study, CT was the modality to which all other methods were compared. CT AGP was measured from an orthogonal line between the anterior later... περισσότερα »
Observations on Prostaglandin Orbitopathy
Observations on Prostaglandin Orbitopathy: Purpose: To present the various orbital soft-tissue changes that can result from the use of topical prostaglandin analogs. Methods: A case series of patients seen in a referral oculoplastic practice with presumed prostaglandin orbitopathy. Results: Thirty-five patients were found to have a variety of disorders, including deepening of the superior sulci (24/35), hypertrichosis (32/35), periocular erythema (24/35), and meibomian gland dysfunction (18/35). Marginal eyelid thinning with posterior migration of the lash line was commonly present... περισσότερα »
Endoscopic Approach to Management of a Lacrimal Sac Diverticula
Endoscopic Approach to Management of a Lacrimal Sac Diverticula: [image: Collapse Box]Author Information Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. Accepted for publication May 2, 2015. The author has no financial or conflicts of interest to disclose. Address correspondence and reprint requests to Mohammad Javed Ali, F.R.C.S., Dacryology Service, L.V. Prasad Eye Institute, Hyderabad, India. E-mail: drjaved007@gmail.com Lacrimal sac diverticulae are uncommon and characterized by a cystic structure communicating with the sac and can be congenital or acquired. A 3...περισσότερα »
Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair
Comparison of Fasanella-Servat and Small-Incision Techniques for Involutional Ptosis Repair: Purpose: To compare the results of the classic Fasanella-Servat internal approach to the newer, small-incision external approach in the repair of involutional ptosis. Methods: Retrospective review identified 93 patients (104 surgical procedures) at Northwestern Ophthalmology from June 2005 until October 2011 who underwent either the Fasanella-Servat or the small-incision approaches for involutional ptosis repair. Change in vertical palpebral fissure measurement, change in marginal reflex dis...περισσότερα »
Orbital Sarcoid-Like Granulomatosis After Inhibition of Tumor Necrosis Factor-α
Orbital Sarcoid-Like Granulomatosis After Inhibition of Tumor Necrosis Factor-α: [image: image] Pharmacologic inhibition of tumor necrosis factor-alpha (TNF-α) has been used in the management of a variety of inflammatory conditions. Recently, reports on the development of sarcoid-like granulomatous disease at multiple systemic sites after treatment with TNF-α inhibitors have emerged, although, to the authors’ knowledge, orbital manifestations of this problem have not been previously described. A 48-year-old woman who received injections of adalimumab for the treatment of psoriatic ... περισσότερα »
Eyelid Dermal Keratinous Cysts of Pilosebaceous Origin
Unusual Eyelid Dermal Keratinous Cysts of Pilosebaceous Origin: [image: image] Purpose: To describe 2 types of previously unrecognized dermal keratinous cysts of the eyelids—2 single sebaceous duct cysts derived from the glands of Zeis and 2 cases of multiple eruptive vellus hair cysts, both types associated with the pilosebaceous apparatus. Methods: Clinical records and paraffin sections subjected to hematoxylin and eosin and acid-fast staining were critically reviewed from each case, and additional sections were immunoreacted for cytokeratins (CKs) 7, 14, and 17. Results: Two pa...περισσότερα »
Bacteremia Following Nasolacrimal Duct Probing
Bacteremia Following Nasolacrimal Duct Probing: Is There a Role of Preoperative Antibiotic Prophylaxis?: [image: image]Aim: To study the incidence of nasolacrimal duct probing-induced bacteremia using the metabolic colorimetric sensor technique of blood culture. Methods: Prospective, interventional study of all consecutive patients who underwent endoscopic-guided probing for congenital nasolacrimal duct obstruction (CNLDO). All patients were operated by a single surgeon (MJA). Blood was drawn under strict aseptic conditions before and after probing. Blood culture was performed using... περισσότερα »
Orbital Radiation Therapy in Thyroid Eye Disease
Orbital Radiation Therapy in Thyroid Eye Disease: [image: image]Purpose: To review the current literature summarizing the state of knowledge on the use of orbital radiation therapy (ORT) in thyroid eye disease. Methods: A systematic review and analysis of the literature were performed. MEDLINE/PubMed, Cochrane Library databases, SCOPUS, and recent relevant journal articles were searched. Results: Thyroid eye disease is an autoimmune disorder that has the propensity to affect multiple orbital tissues and can cause permanent vision loss. In moderate to severe disease, treatment may be...περισσότερα »
Electrococleografía extratimpánica
Electrococleografía extratimpánica en una población normal. Estudio descriptivo via Acta Otorrinolaringológica Española Publication date: Available online 8 March 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Jaume Redondo-Martínez, Antonio Morant-Ventura, Diana Robledo-Aguayo, Alejandra Ayas-Montero, Elvira Mencheta-Benet, Jaime Marco-Algarra Introducción y objetivosLa electrococleografía extratimpánica es un registro elecrofisiológico que refleja la actividad eléctrica acontecida en la cóclea tras un estímulo sonoro. Se obtiene mediante la aplicación del estímulo en e...περισσότερα »
Primary Cutaneous Coccidioidomycosis of the Eyelid
Primary Cutaneous Coccidioidomycosis of the Eyelid: A Case Report: [image: image] A 33-year-old man presented with an ulcerated nodule on his left eyelid and eyebrow that was unresponsive to broad-spectrum antibiotics. Incisional biopsies were performed, and cultures were positive for Coccidioides immitis. An extensive work-up revealed no systemic involve ment of disseminated coccidioidomycosis. The patient was treated with oral itraconazole for 6 months with resolution of the lesion. Few cases of primary cutaneous coccidioidomycosis have been reported. The authors describe a prima...περισσότερα »
Pin stuck in nose
5-year-old gets safety pin stuck in nose for 6 months: HEMET, Calif. — A 5-year-old California girl is feeling much better after a safety pin that had been lodged in her nose for six months came out. 6ABC.com reported Khloe Russell started experiencing a constant runny nose. "Her nose just started (running) out of this one side. Green, green, green constantly and it stunk," said Katelyn Powell, Khole's mother. Powell took Khloe to three different doctors in an attempt to solve the runny nose problem, all of whom thought she had a sinus infection. "We went home, did 10 days of medic... περισσότερα »
PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor
Dose Finding Study Of PF-05212384 With Paclitaxel And Carboplatin In Patients With Advanced Solid Tumor: *Conditions*: Breast Cancer; NSCLC; Ovary Cancer; Endometrial Cancer; Small Cell Lung Cancer (SCLC); Head and Neck (HNSCC) *Interventions*: Drug: PF-05212384; Drug: Paclitaxel; Drug: Carboplatin *Sponsor*: Cristiana Sessa This is a phase Ib single arm, open-label, multiple dose, dose escalating, safety, pharmacokinetic and pharmacodynamic study of the combination of PF-05212384 with paclitaxel and carboplatin. The study will be conducted in adult patients ... περισσότερα »
Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer
Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer: *Condition*: Cancer of the Oropharynx *Intervention*: Radiation: Stereotactic Radiosurgery *Sponsor*: Northwell Health ArmsAssigned Interventions Experimental: Cohort 1 Patients will receive 6 weeks of Intensity-Modulated Radiation Therapy (IMRT) (standard of care) followed by the dose escalated stereotactic radiosurgery (SRS Boost). Cohort 1 will receive 8 Gy in a single fraction, cohort 2 will receive 10 Gy in a single fraction and cohort 3 will receive 10 Gy split into two fractions. Radiatio... περισσότερα »
Endoscopic Evaluation After Esophagectomy
Endoscopic Evaluation After Esophagectomy: *Conditions*: Esophageal Neoplasms; Constriction; Anastomotic Leak; Ischemia *Intervention*: Procedure: Patients after esophagectomy *Sponsor*: Nagasaki University Groups/CohortsAssigned Interventions Patients after esophagectomy Endoscopic examinations are performed at 1, 8, and 15 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated. Procedure: Patients after esophagectomy postoperative endoscopic evaluation Detailed Description:Gastric conduit ischemia or anastomotic breakdown after eso...περισσότερα »
Disorders mainly of the upper respiratory tract were the predominant causes of illness among foreign travelers. Traveler's diarrhea was the most common specific diagnosis but the prevalence within the total population was not very high.
Morbidity and Outcomes of Foreign Travelers in Zakynthos Island, Greece: A Retrospective Study: Background Although there is satisfactory recording of diseases affecting travelers visiting developing countries, little is known regarding morbidity of travelers when visiting developed countries. We sought to evaluate the morbidity of foreign travelers in Zakynthos, a popular Greek island attracting large number of foreign tourists every summer. Methods Data from foreign travelers that accommodated in Zakynthos and sought medical services from the private offices of Zante Medical Ca... περισσότερα »
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine: AbstractVestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and in migraine and normal control subjects during fixed-radius centrifugation, a paradigm that simultaneously modulates afferent ... περισσότερα »
Prognostic factors for local control in patients receiving radiation therapy for early glottic cancer: anterior commissure involvement and effect of chemoradiotherapy
Prognostic factors for local control in patients receiving radiation therapy for early glottic cancer: anterior commissure involvement and effect of chemoradiotherapy: AbstractTo assess the prognostic factors for local control in patients with early glottic cancer, we retrospectively analyzed the data of 130 consecutive patients who were treated by definitive radiation therapy (RT) or concurrent chemoradiotherapy (CRT) for early glottic squamous cell carcinoma (UICC sixth edition T1N0M0 and T2N0M0) at Kanagawa cancer center between 1999 and 2011. There were 63 patients with T1 canc... περισσότερα »
One stage combined endoscopic and per-oral buccal fat pad approach for large oro-antral-fistula closure with secondary chronic maxillary sinusitis
One stage combined endoscopic and per-oral buccal fat pad approach for large oro-antral-fistula closure with secondary chronic maxillary sinusitis: AbstractThere are numerous surgical approaches for oro-antral-fistula (OAF) closure. Secondary sinus disease is still considered by many experts a relative contra indication for primary closure. To describe a single-stage combined endoscopic sinus surgery and per-oral buccal fat pad (BFP) flap approach for large OAF causing chronic maxillary sinusitis. The records of all the patients with OAF and chronic manifestations of secondary rhi... περισσότερα »
Laryngopharyngeal symptoms in patients with chronic obstructive pulmonary disease
Laryngopharyngeal symptoms in patients with chronic obstructive pulmonary disease: AbstractThe aim of the study was to report on the prevalence and severity of laryngopharyngeal symptoms in patients with COPD compared to controls. A total of 27 patients with COPD and 13 controls matched according to age and gender were included. Demographic data included age, gender, history of smoking and history of allergic rhinitis. The Reflux symptom Index described by Belafsky et al. was used. The frequency and average score of each of the laryngopharyngeal symptoms were computed. The mean age...περισσότερα »
Comparative analysis of the expression of E-cadherin, β-catenin, and β1 integrin in congenital and acquired cholesteatoma
Comparative analysis of the expression of E-cadherin, β-catenin, and β1 integrin in congenital and acquired cholesteatoma: AbstractE-cadherin, β-catenin, and β1 integrin are important cell adhesion molecules to maintain epithelial structure and function. We investigated the expression of these cell adhesion molecules in cholesteatomas to understand the role of cell–cell and cell–extracellular matrix interaction in cholesteatomas. An immunohistochemical investigation was carried out on 35 cholesteatoma tissue samples (14 congenital, 21 acquired cholesteatomas) and 10 normal retroaur... περισσότερα »
Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model
Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model: AbstractThe aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups... περισσότερα »
The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects
The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects: AbstractSystemic treatment with corticosteroids shows therapeutic effects, few patients benefit from intranasal topical drug application, probably due to limited access of the drug to the olfactory epithelium. The aim of the present study was to investigate how drops distribute within the nasal cavity when the “Kaiteki” position is performed. Thirteen healthy volunteers participated. Subjects were lying on the side with the head til... περισσότερα »
Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO)
Supraglottoplasty as treatment of exercise induced laryngeal obstruction (EILO): AbstractBreathing difficulties during exertion may be caused by exercise-induced laryngeal obstruction (EILO). The diagnosis depends on visualization of the larynx during exercise, i.e. by continuous laryngoscopic exercise (CLE) test. In case of severe supraglottic collapse and pronounced symptoms during strenuous exertion, surgical treatment (supraglottoplasty) has been suggested. The aims of this study were to evaluate outcome and patient satisfaction after supraglottoplasty for EILO and to compare ...περισσότερα »
Endoscopic endonasal multilayer repair of traumatic CSF rhinorrhea
Endoscopic endonasal multilayer repair of traumatic CSF rhinorrhea: AbstractThe incidence of traumatic CSF has increased in recent years due to increased incidence of road traffic accidents (RTA) as well the increasing number of endoscopic sinus surgeries (ESS). The objective of this study is to present our experience in management of traumatic CSF leaks using the endoscopic multilayer repair technique. Forty-two patients (aged 10–75 years, 30 males and 12 females) presenting with confirmed post-traumatic CSF rhinorrhea were operated upon between January 2007 and December 2013. The...περισσότερα »
Treating thyroglossal duct cysts with a “conservative” Sistrunk approach
A 16-year experience in treating thyroglossal duct cysts with a “conservative” Sistrunk approach: AbstractAlthough Sistrunk operation is the standard method to treat thyroglossal duct cyst, the reported recurrence rates after a “classic” or “modified” Sistrunk procedure still varied from 0 to 15.8 %, indicating the existence of some technical uncertainties. While simple cystectomy has been recognized as the most important prognostic factor predicting thyroglossal duct cyst recurrence, whether other clinico-pathological parameters also affect disease recurrence has not been well stu... περισσότερα »
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine: AbstractVestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and in migraine and normal control subjects during fixed-radius centrifugation, a paradigm that simultaneously modulates afferent ... περισσότερα »
Mucocele
Mucocele – Caso 1: Imagens Mucocele – Caso 1
Fronto Etimoidite mucocele
Fronto Etimoidite mucocele: Imagens Fronto Etimoidite
Dente
Dente: Imagens Dente
Corpo Estranho
Corpo Estranho: Imagem Corpo Estranho
Fratura Blow Out
Fratura Blow Out: Imagem Fratura Blow Out
Sinusite Fúngica
Sinusite Fúngica: Imagem Sinusite Fúngica
Sinusite Complicação Orbitária
Sinusite Complicação Orbitária: Imagem Sinusite Complicação Orbitária
Seio Silencioso
Seio Silencioso: Imagens Seio Silencioso
Nível Líquido
Nível Líquido – Caso 2: Imagem Nível Líquido – Caso 2
Nível líquido
Nível líquido: Imagens Nível líquido
High Prevalence of Systemic Autoimmune Diseases in Patients with Meniere's Disease
High Prevalence of Systemic Autoimmune Diseases in Patients with Menière's Disease: Background Autoimmunity appears to be associated with the pathophysiology of Meniere's disease (MD), an inner ear disorder characterized by episodes of vertigo associated with hearing loss and tinnitus. However, the prevalence of autoimmune diseases (AD) in patients with MD has not been studied in individuals with uni or bilateral sensorineural hearing loss (SNHL). Methods and Findings We estimated the prevalence of AD in 690 outpatients with MD with uni or bilateral SNHL from otoneurology clinic... περισσότερα »
Betahistine Exerts a Dose-Dependent Effect on Cochlear Stria Vascularis Blood Flow in Guinea Pigs In Vivo
Betahistine Exerts a Dose-Dependent Effect on Cochlear Stria Vascularis Blood Flow in Guinea Pigs In Vivo: Objective Betahistine is a histamine H1-receptor agonist and H3-receptor antagonist that is administered to treat Menière’s disease. Despite widespread use, its pharmacological mode of action has not been entirely elucidated. This study investigated the effect of betahistine on guinea pigs at dosages corresponding to clinically used doses for cochlear microcirculation. Methods Thirty healthy Dunkin-Hartley guinea pigs were randomly assigned to five groups to receive betah... περισσότερα »
Predictive Modeling for Diagnostic Tests with High Specificity, but Low Sensitivity: A Study of the Glycerol Test in Patients with Suspected Meniere's Disease
Predictive Modeling for Diagnostic Tests with High Specificity, but Low Sensitivity: A Study of the Glycerol Test in Patients with Suspected Menière’s Disease: A high specificity does not ensure that the expected benefit of a diagnostic test outweighs its cost. Problems arise, in particular, when the investigation is expensive, the prevalence of a positive test result is relatively small for the candidate patients, and the sensitivity of the test is low so that the information provided by a negative result is virtually negligible. The consequence may be that a potentially useful ... περισσότερα »
Unilateral Vestibular Loss Impairs External Space Representation
Unilateral Vestibular Loss Impairs External Space Representation: The vestibular system is responsible for a wide range of postural and oculomotor functions and maintains an internal, updated representation of the position and movement of the head in space. In this study, we assessed whether unilateral vestibular loss affects external space representation. Patients with Menière's disease and healthy participants were instructed to point to memorized targets in near (peripersonal) and far (extrapersonal) spaces in the absence or presence of a visual background. These individuals wer... περισσότερα »
Visualization of White Matter Tracts Using a Non-Diffusion Weighted Magnetic Resonance Imaging Method: Does Intravenous Gadolinium Injection Four Hours Prior to the Examination Affect the Visualization of White Matter Tracts?
Visualization of White Matter Tracts Using a Non-Diffusion Weighted Magnetic Resonance Imaging Method: Does Intravenous Gadolinium Injection Four Hours Prior to the Examination Affect the Visualization of White Matter Tracts?: Objectives Visualization of white matter (WM)-tracts such as the corticospinal tract (CST), medial lemniscus (ML), and superior cerebellar peduncle (SCP) using delayed enhanced (DE)-heavily T2-weighted three-dimensional fluid-attenuated inversion-recovery (hT2w-3D-FLAIR) imaging has recently been reported. In that report, all patients were clinically suspecte... περισσότερα »
Covert Anti-Compensatory Quick Eye Movements during Head Impulses
Covert Anti-Compensatory Quick Eye Movements during Head Impulses: Background Catch-up saccades during passive head movements, which compensate for a deficient vestibulo-ocular reflex (VOR), are a well-known phenomenon. These quick eye movements are directed toward the target in the opposite direction of the head movement. Recently, quick eye movements in the direction of the head movement (covert anti-compensatory quick eye movements, CAQEM) were observed in older individuals. Here, we characterize these quick eye movements, their pathophysiology, and clinical relevance during he... περισσότερα »
Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate
Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate: Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using li...περισσότερα »
Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease
Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease: Meniere's disease is an episodic vestibular syndrome associated with sensorineural hearing loss (SNHL) and tinnitus. Patients with MD have an elevated prevalence of several autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and psoriasis), which suggests a shared autoimmune background. Functional variants of several genes involved in the NF-κB pathway, such as *REL*, *TNFAIP3*, *NFKB1* and *TNIP1...περισσότερα »
Fast, semi-quantitative evaluation of endolymphatic hydrops is highly reliable compared to quantitative/volumetric assessment. Endolymphatic space is significantly higher in patients with longer sickness duration.
Semi-Quantitative vs. Volumetric Determination of Endolymphatic Space in Menière’s Disease Using Endolymphatic Hydrops 3T-HR-MRI after Intravenous Gadolinium Injection: Magnetic resonance imaging enhances the clinical diagnosis of Menière's disease. This is accomplished by in vivo detection of endolymphatic hydrops, which are graded using different semi-quantitative grading systems. We evaluated an established, semi-quantitative endolymphatic hydrops score and with a quantitative method for volumetric assessment of the endolymphatic size. 11 patients with Menière's disease and ...περισσότερα »
Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake
Change in and Long-Term Investigation of Neuro-Otologic Disorders in Disaster-Stricken Fukushima Prefecture: Retrospective Cohort Study before and after the Great East Japan Earthquake: On March 11, 2011, Japan’s northeast Pacific coast was hit by a gigantic earthquake and subsequent tsunami. Soma City in Fukushima Prefecture is situated approximately 44 km north of Fukushima Daiichi Nuclear Power Plant. Soma General Hospital is the only hospital in Soma City that provides full-time otolaryngological medical care. We investigated the changes in new patients from one year before to... περισσότερα »
Sialolithiasis in an Accessory Submandibular Gland Identified by Magnetic Resonance Sialography
Sialolithiasis in an Accessory Submandibular Gland Identified by Magnetic Resonance Sialography: Background: Accessory submandibular gland is a very rare anatomical variant. There have been only 6 reported cases of this entity in the English literature, only 1 of which was identified using magnetic resonance imaging. Methods: We report the case of a 39-year-old female with symptoms of left submandibular sialoadenitis who was diagnosed of sialolithiasis within the left accessory submandibular gland by magnetic resonance sialography (MR-Si). Results: The calculus was palpated near ...περισσότερα »
The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma
The Association between Genetic Polymorphism and the Processing Efficiency of miR-149 Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma: MicroRNAs (miRNAs) play important roles in modulating the neoplastic process of cancers including head and neck squamous cell carcinoma (HNSCC). A genetic polymorphism (rs2292832, C>T) has been recently identified in the precursor of *miR-149*; nevertheless its clinicopathological implications remain obscure. In this study, we showed that *miR-149* is down-regulated in HNSCC compared to normal mucosa and this is associate... περισσότερα »
Cell Growth Dynamics in Embryonic and Adult Mouse Thyroid Revealed by a Novel Approach to Detect Thyroid Gland Subpopulations
Cell Growth Dynamics in Embryonic and Adult Mouse Thyroid Revealed by a Novel Approach to Detect Thyroid Gland Subpopulations: Thyroid , Vol. 0, No. 0. Author information Sanjay Gawade,1 Carlos Mayer,1 Katrin Hafen,1 Thomas Barthlott,1 Werner Krenger,1 and Gabor Szinnai1,2 1Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland. 2Pediatric Endocrinology, University Children's Hospital Basel, University of Basel, Basel, Switzerland. Address correspondence to: *Gabor Szinnai, MD, PhD* *Pediatric Endocrinology* *University Children's Hospital Basel an...περισσότερα »
Oxidants are increased and antioxidants decreased in euthyroid HT patients. As a result, the oxidative/antioxidative balance is shifted toward the oxidative side. Moreover, this study reports on a possible significant involvement of AGEs in HT, thus contributing to a better definition of the redox homoeostasis dysregulation in HT.Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis
Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis: Author information Rosaria M. Ruggeri,1* Teresa M. Vicchio,1* Mariateresa Cristani,2 Rosaria Certo,1 Daniela Caccamo,3Angela Alibrandi,4 Salvatore Giovinazzo,1 Antonina Saija,2 Alfredo Campennì,3 Francesco Trimarchi,1,5 and Sebastiano Gangemi6 1Department of Clinical and Experimental Medicine, Division of Endocrinology, University of Messina, Messina,Italy. 2Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy. 3Department of Biomedical Sciences and Morp... περισσότερα »
Normoxic accumulation of HIF1α is associated with glutaminolysis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Objectives The stabilization of the transcription factor and prognostic tumor marker hypoxia-inducible factor 1α (HIF1α) is considered to be crucial for cellular metabolic adaptations to hypoxia. However, HIF1α has also been shown to accumulate under normoxic conditions, although this phenomenon is poorly understood. Methods We investigated the conditions for normoxic HIF1α stabilization in different tumor cell lines (e.g., two mammary carcinoma cell lines and three oral squamous cell carcinoma cell lines) via Western blot analysis or immunohistochemical staining. The tr... περισσότερα »
Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis
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{alpha}B-crystallin Interacts with Nav1.5 and Regulates Ubiquitination and Internalization of Cell Surface Nav1.5 Molecular Bases of Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nav1.5, the pore-forming α subunit of the cardiac voltage-gated Na+ channel complex, is required for the initiation and propagation of the cardiac action potential. Mutations in Nav1.5 cause cardiac arrhythmias and sudden death. The cardiac Na+ channel functions as a protein complex, however, its complete components remain to be fully elucidated. A yeast two-hybrid screen […]
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