Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin
[image: fig-1-1x.jpg] Besides its anti-inflammatory, analgesic and anti-pyretic properties, aspirin is used for the prevention of cardiovascular disease and various types of cancer. The multiple activities of aspirin likely involve several molecular targets and pathways rather than a single target. Therefore, systematic identification of these targets of aspirin can help us understand the underlying mechanisms of the activities. In this study, we identified 23 putative targets of aspirin in the human proteome by using binding pocket similarity detecting tool combination with molecu... περισσότερα »
Genetic diversity and structure in the Endangered Allen Cays Rock Iguana, Cyclura cychlura inornata
[image: fig-1-1x.jpg] The Endangered Allen Cays Rock Iguana (Cyclura cychlura inornata) is endemic to the Allen Cays, a tiny cluster of islands in the Bahamas. Naturally occurring populations exist on only two cays ( from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1UUQGdK via IFTTT
Esophageal Ulcer as a Cause of Death: A Population-Based Study. Mortality of Esophageal Ulcer Disease.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Esophageal Ulcer as a Cause of Death: A Population-Based Study. Mortality of Esophageal Ulcer Disease.* Digestion. 2015;91(4):272-6 Authors: Rantanen TK, Sihvo EI, Räsänen JV, Hynninen M, Salo JA Abstract BACKGROUND: This study aimed at defining the mortality and the nature of fatal complications that arise out of esophageal ulcer for one clearly defined geographical area. METHODS: In this national, population-based study, the occurrence of fatal esophageal ulcer or ulcer requiring hospital treatment between Janua... περισσότερα »
Concomitant fundoplication increases morbidity of gastrostomy tube placement.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Concomitant fundoplication increases morbidity of gastrostomy tube placement.* J Pediatr Surg. 2015 Jul;50(7):1104-8 Authors: Berman L, Sharif I, Rothstein D, Hossain J, Vinocur C Abstract BACKGROUND: Fundoplication is often performed in conjunction with gastrostomy tube (GT) placement in children, but there is a great deal of variation in rates of and indications for this procedure. Little is known about the impact of fundoplication on peri-operative outcomes. This study examines a national cohort of pediatric p... περισσότερα »
Quality of reporting of the literature on gastrointestinal reflux after repair of esophageal atresia-tracheoesophageal fistula.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Quality of reporting of the literature on gastrointestinal reflux after repair of esophageal atresia-tracheoesophageal fistula.* J Pediatr Surg. 2015 Jul;50(7):1099-103 Authors: Shawyer AC, Pemberton J, Kanters D, Alnaqi AA, Flageole H Abstract OBJECTIVES: There is variation in the management of postoperative gastroesophageal reflux (GER) in esophageal atresia-tracheoesophageal fistula (EA-TEF). Well-reported literature is important for clinical decision-making. We assessed the quality of reporting (QOR) of posto... περισσότερα »
Selective inhibition of nitric oxide synthase causes increased muscle thickness in rat esophagus.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Selective inhibition of nitric oxide synthase causes increased muscle thickness in rat esophagus.* J Pediatr Surg. 2015 Jul;50(7):1112-4 Authors: Soyer T, Boybeyi Ö, Atasoy P Abstract AIM: Achalasia is a primary motor dysfunction of esophagus which can be created experimentally by nitric oxide synthase (NOS) inhibition. Although several theories have been suggested, mechanism of increased esophageal muscle thickness in achalasia is still unclear. An experimental study was performed to evaluate the esophageal musc... περισσότερα »
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?
*How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?* Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):163-169 Authors: Henriques de Figueiredo B, Grégoire V Abstract PURPOSE OF REVIEW: Radiotherapy is one of the most effective treatment modalities for head and neck cancer. However, because of the intricacy between tumors and normal tissues, it can induce morbidity, such as mucositis, dermatitis, xerostomia, dysphagia, hearing loss, vision impairment, skin fibrosis, and osteoradionecrosis of the jaw, and it can dramatically impact on patient quality of life....περισσότερα »
Upper gastrointestinal diseases in patients for endoscopy in South-Western Uganda.
*Upper gastrointestinal diseases in patients for endoscopy in South-Western Uganda.* Afr Health Sci. 2015 Sep;15(3):959-66 Authors: Obayo S, Muzoora C, Ocama P, Cooney MM, Wilson T, Probert CS Abstract BACKGROUND: There is a paucity of published data regarding upper gastrointestinal diseases in Ugandans with upper gastrointestinal symptoms referred for endoscopy. OBJECTIVES: To study the presenting complaints, pathology and Helicobacter pylori prevalence among patients with upper gastrointestinal symptoms in South-Western Uganda. METHODS: Patients presenting with upper gastrointes... περισσότερα »
[Clinical analysis of three cases with infant botulism and review of literature].
*[Clinical analysis of three cases with infant botulism and review of literature].* Zhonghua Er Ke Za Zhi. 2016 Mar 2;54(3):214-7 Authors: Zhang J, Xu WR, Zhao MM, Wu Y, Zhang X, Zhang CY, Wang Y, Liu XQ, Lu S, Xu XF Abstract OBJECTIVE: To analyze the clinical characteristics and diagnosis of three cases with infant botulism. METHOD: Clinical data of three clinically diagnosed cases with infant botulism in May 2015 in Peking University First Hospital were retrospectively analyzed. Literature search at databases of PubMed, Wanfang, China National Knowledge Infrastructure and VIP w... περισσότερα »
Evolving Management of Zenker's Diverticulum in the Endoscopic Era: A North American Experience.
*Evolving Management of Zenker's Diverticulum in the Endoscopic Era: A North American Experience.* World J Surg. 2016 Mar 8; Authors: Jones D, Aloraini A, Gowing S, Cools-Lartigue J, Leimanis M, Tabah R, Ferri L Abstract BACKGROUND: Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utilizing an electrosurgical needle knife. We sou...περισσότερα »
Nursing Bedside Dysphagia Screen: Is It Valid?
Related Articles *Nursing Bedside Dysphagia Screen: Is It Valid?* J Neurosci Nurs. 2016 Apr;48(2):80-1 Authors: McNett M PMID: 26954917 [PubMed - in process] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1pz2rdT
The effect of subthalamic deep brain stimulation on gastric motility in Parkinson's disease.
Related Articles *The effect of subthalamic deep brain stimulation on gastric motility in Parkinson's disease.* Parkinsonism Relat Disord. 2016 Feb 15; Authors: Krygowska-Wajs A, Furgala A, Gorecka-Mazur A, Pietraszko W, Thor P, Potasz-Kulikowska K, Moskala M Abstract OBJECTIVE: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is well established for treating the motor symptoms for advanced Parkinson's disease (PD) but its effects on gastric myoelectrical activity and gastrointestinal symptoms have not been well studied. The aim of this study was to evaluate the effect...περισσότερα »
Defining characteristics and risk indicators for diagnosing nursing home-acquired pneumonia and aspiration pneumonia in nursing home residents, using the electronically-modified Delphi Method.
Related Articles *Defining characteristics and risk indicators for diagnosing nursing home-acquired pneumonia and aspiration pneumonia in nursing home residents, using the electronically-modified Delphi Method.* BMC Geriatr. 2016;16(1):60 Authors: Hollaar V, van der Maarel-Wierink C, van der Putten GJ, van der Sanden W, de Swart B, de Baat C Abstract BACKGROUND: In nursing home residents, it is not possible to distinguish pneumonia and aspiration pneumonia clinically. International literature reveals no consensus on which and how many characteristics and risk indicators must be p... περισσότερα »
Unilateral versus bilateral wrap crural fixation in laparoscopic Nissen fundoplication for children.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Unilateral versus bilateral wrap crural fixation in laparoscopic Nissen fundoplication for children.* JSLS. 2014 Oct-Dec;18(4) Authors: Hassan ME Abstract INTRODUCTION: Gastroesophageal reflux (GERD) is common in neurologically impaired (NI) children. Fundoplication and gastrostomy have previously been indicated in NI children with GERD who have not responded to medical treatment. The most common reason for fundoplication failure is intrathoracic migration of the wrap. OBJECTIVE: The aim of the study is to measure the effect ... περισσότερα »
Esophageal Eosinophilia Treated With Long-Duration Proton Pump Inhibitor Therapy.
*Esophageal Eosinophilia Treated With Long-Duration Proton Pump Inhibitor Therapy.* ACG Case Rep J. 2016 Jan;3(2):95-7 Authors: DiGiovanni EL, Champeaux AL, Arroyo MR, Richter JE Abstract We present a case of proton pump inhibitor-responsive eosinophilic esophagitis (PPI-REE) in a patient with severe dysphagia and markedly elevated baseline esophageal eosinophilia that was previously deemed unresponsive to PPI. Upon reintroduction to PPI therapy with monthly endoscopy and dilation over the course of 4 months, the patient improved clinically and resolved her mucosal eosinophilia. ... περισσότερα »
Swallowing dysfunction in myotonic dystrophy: a retrospective study of symptomatology and radiographic findings.
Related Articles *Swallowing dysfunction in myotonic dystrophy: a retrospective study of symptomatology and radiographic findings.* B-ENT. 2015;11(4):249-56 Authors: Willaert A, Jorissen M, Goeleven A Abstract BACKGROUND: Swallowing dysfunction is a common symptom of myotonic dystrophy, but it is poorly documented in large patient series. This retrospective study was designed to investigate the presence of swallowing symptoms in a large study population and to describe a specific pattern of clinical and radiographic abnormalities. METHODS: A retrospective analysis was made of 169 ... περισσότερα »
Independent Tray Service: A Program To Enhance Meals. MODIFYING HOW RESIDENTS WITH DYSPHAGIA ARE SERVED IMPROVES THEIR HEALTH AND RESTORES THEIR DIGNITY.
Related Articles *Independent Tray Service: A Program To Enhance Meals. MODIFYING HOW RESIDENTS WITH DYSPHAGIA ARE SERVED IMPROVES THEIR HEALTH AND RESTORES THEIR DIGNITY.* Provider. 2015 Nov;41(11):29-30 Authors: Rosenberg H PMID: 26689024 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1LTjNfA
Comparative efficacy of esomeprazole and omeprazole: Racemate to single enantiomer switch.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Comparative efficacy of esomeprazole and omeprazole: Racemate to single enantiomer switch.* Daru. 2015;23:50 Authors: Asghar W, Pittman E, Jamali F Abstract BACKGROUND: Both omeprazole and its S enantiomer (esomeprazole) have been available and used to treat symptoms of gastroesophageal reflux disease (GERD) and conditions associated with excessive stomach acid secretion for more than a decade. Controversy exists over improved efficacy of S enantiomer (esomeprazole) over parent racemate ... περισσότερα »
Therapeutic strategies in eosinophilic esophagitis: Induction, maintenance and refractory disease.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Therapeutic strategies in eosinophilic esophagitis: Induction, maintenance and refractory disease.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):829-39 Authors: Sodikoff J, Hirano I Abstract Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease that is increasingly recognized as one of the most common causes of dysphagia and foregut symptoms in adults and children. Topical corticosteroids, elimination diets, and esophageal dilations are effective options for both induction and maintenance thera... περισσότερα »
Esophageal dilation in eosinophilic esophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Esophageal dilation in eosinophilic esophagitis.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):815-28 Authors: Richter JE Abstract Tissue remodeling with scaring is common in adult EoE patients with long standing disease. This is the major factor contributing to their complaints of solid food dysphagia and recurrent food impactions. The best tests to define the degree of remodeling are barium esophagram, high resolution manometry and endoscopy. Many physicians are fearful to dilate EoE patients because of con... περισσότερα »
Elimination and elemental diet therapy in eosinophilic oesophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Elimination and elemental diet therapy in eosinophilic oesophagitis.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):793-803 Authors: Warners MJ, Vlieg-Boerstra BJ, Bredenoord AJ Abstract Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disorder of the oesophagus. The incidence of EoE has been raised substantially and EoE has recently become the most prevalent cause of dysphagia among the adolescents. Food and aeroallergens are believed to play a major role in the pathogenesis. Current treatment incl... περισσότερα »
Diagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Diagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):783-92 Authors: Schoepfer A Abstract Eosinophilic oesophagitis (EoE) has first been described a little over 20 years ago. EoE has been defined by a panel of international experts as a "chronic, immune/antigen-mediated, oesophageal disease, characterized clinically by symptoms related to oesophageal dysfunction and histologically by eosinophil-predominant inflammation". A value of ≥ 15 eosinophi... περισσότερα »
Interactions between gastro-oesophageal reflux disease and eosinophilic oesophagitis.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Interactions between gastro-oesophageal reflux disease and eosinophilic oesophagitis.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):749-58 Authors: Molina-Infante J, van Rhijn BD Abstract Gastro-oesophageal reflux disease (GORD) is the most common oesophageal disorder, whereas eosinophilic oesophagitis (EoE) is an emerging disease unresponsive to PPI therapy. Updated guidelines in 2011 described proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE), a novel phenotype in EoE patients who were resp... περισσότερα »
Clinical features of Eosinophilic esophagitis in children and adults.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Clinical features of Eosinophilic esophagitis in children and adults.* Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):739-48 Authors: Miehlke S Abstract Eosinophilic esophagitis (EoE) may affect humans at any age with a predominance for Caucasian males. The clinical manifestation of EoE varies depending on the patient's age. Infants and young children may primarily present with unspecific symptoms such as feeding problems, vomiting and abdominal pain. In adolescents and adults, dysphagia and food impactation be... περισσότερα »
Recent advances in the recognition and management of eosinophilic esophagitis.
[image: http:--http://ift.tt/1fm4duf] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Recent advances in the recognition and management of eosinophilic esophagitis.* Can J Gastroenterol Hepatol. 2015 Jun-Jul;29(5):237-40 Authors: Eustace G, Gui X, Iacucci M Abstract The incidence and recognition of eosinophilic esophagitis is increasing. Pathophysiological understanding of eosinophilic esophagitis is improving and an immunological reaction to ingested food is likely to play a significant role. Patients present with dysphagia and food bolus obstruction. Both histological a... περισσότερα »
Correlation between laryngobronchoscopy and pepsin in the diagnosis of extra-oesophageal reflux.
Related Articles *Correlation between laryngobronchoscopy and pepsin in the diagnosis of extra-oesophageal reflux.* J Laryngol Otol. 2015 Jun;129(6):572-9 Authors: Krishnan U, Paul S, Messina I, Soma M Abstract OBJECTIVE: This study aimed to investigate pepsin as a marker of extra-oesophageal reflux disease by examining its presence in tracheal aspirates and correlating it with macroscopic changes on laryngobronchoscopy, along with the results of standard tests for gastro-oesophageal reflux disease and clinical features. METHODS: A retrospective review was undertaken of a cohort o...περισσότερα »
Cardiopexy with Ligamentum Teres in Patients with Hiatal Hernia and Previous Sleeve Gastrectomy: An Alternative Treatment for Gastroesophageal Reflux Disease.
[image: http:--production.springer.de-OnlineReso] Related Articles *Cardiopexy with Ligamentum Teres in Patients with Hiatal Hernia and Previous Sleeve Gastrectomy: An Alternative Treatment for Gastroesophageal Reflux Disease.* Obes Surg. 2015 Aug;25(8):1539-43 Authors: Gálvez-Valdovinos R, Cruz-Vigo JL, Marín-Santillán E, Funes-Rodríguez JF, López-Ambriz G, Domínguez-Carrillo LG Abstract BACKGROUND: Fifty percent of patients who have undergone sleeve gastrectomy have gastroesophageal reflux disease (GERD). Surgical reinforcement of the lower esophageal sphincter is necessary to p... περισσότερα »
Tracheoesophageal fistula length decreases over time.
Related Articles *Tracheoesophageal fistula length decreases over time.* Eur Arch Otorhinolaryngol. 2016 Mar 7; Authors: Jiang N, Kearney A, Damrose EJ Abstract The objectives of this study were to demonstrate that the length of the tracheoesophageal voice prosthesis changes over time and to determine whether the prosthesis length over time increased, decreased, or showed no predictable change in size. A retrospective chart review was performed at a tertiary care referral center. Patients who underwent either primary or secondary tracheoesophageal puncture between January 2006 an...περισσότερα »
External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity.
Related Articles *External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity.* Ann Otol Rhinol Laryngol. 2016 Mar 7; Authors: Barsties B, Maryn Y Abstract OBJECTIVES: The Acoustic Voice Quality Index (AVQI) is an objective method to quantify the severity of overall voice quality in concatenated continuous speech and sustained phonation segments. Recently, AVQI was successfully modified to be more representative and ecologically valid because the internal consistency of AVQI was balanced out through equal proportion of the 2 speech types.... περισσότερα »
The nature of articulation errors in Egyptian Arabic-speaking children with velopharyngeal insufficiency due to cleft palate.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The nature of articulation errors in Egyptian Arabic-speaking children with velopharyngeal insufficiency due to cleft palate.* Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1527-32 Authors: Abou-Elsaad T, Baz H, Afsah O, Mansy A Abstract UNLABELLED: Even with early surgical repair, the majority of cleft palate children demonstrate articulation errors and have typical cleft palate speech. OBJECTIVE: Was to determine the nature of articulation errors of Arabic consonants in Egyptian Arabic-speaking children with ve... περισσότερα »
speech and language; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *speech and language* These pubmed results were generated on 2016/03/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Speech via xlomafota13 on Inoreader http://ift.tt/1XeFsiW via IFTTT
Cardiopexy with Ligamentum Teres in Patients with Hiatal Hernia and Previous Sleeve Gastrectomy: An Alternative Treatment for Gastroesophageal Reflux Disease.
[image: http:--production.springer.de-OnlineReso] Related Articles *Cardiopexy with Ligamentum Teres in Patients with Hiatal Hernia and Previous Sleeve Gastrectomy: An Alternative Treatment for Gastroesophageal Reflux Disease.* Obes Surg. 2015 Aug;25(8):1539-43 Authors: Gálvez-Valdovinos R, Cruz-Vigo JL, Marín-Santillán E, Funes-Rodríguez JF, López-Ambriz G, Domínguez-Carrillo LG Abstract BACKGROUND: Fifty percent of patients who have undergone sleeve gastrectomy have gastroesophageal reflux disease (GERD). Surgical reinforcement of the lower esophageal sphincter is necessary to ...περισσότερα »
Potent Gastric Acid Inhibition Over 24 Hours by 4-Times Daily Dosing of Esomeprazole 20 mg.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Potent Gastric Acid Inhibition Over 24 Hours by 4-Times Daily Dosing of Esomeprazole 20 mg.* Digestion. 2015;91(4):277-85 Authors: Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Kagami T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K, Miyajima H, Furuta T Abstract BACKGROUND: When administered at a standard dose, proton pump inhibitors (PPIs) do not always provide sufficient acid inhibition for all subjects, particularly in extensive metabolizers (EMs) of CYP2C19. Whether esomeprazole at a dose of 20 mg four t... περισσότερα »
Esophageal Ulcer as a Cause of Death: A Population-Based Study. Mortality of Esophageal Ulcer Disease.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Esophageal Ulcer as a Cause of Death: A Population-Based Study. Mortality of Esophageal Ulcer Disease.* Digestion. 2015;91(4):272-6 Authors: Rantanen TK, Sihvo EI, Räsänen JV, Hynninen M, Salo JA Abstract BACKGROUND: This study aimed at defining the mortality and the nature of fatal complications that arise out of esophageal ulcer for one clearly defined geographical area. METHODS: In this national, population-based study, the occurrence of fatal esophageal ulcer or ulcer requiring hospital treatment between Janua... περισσότερα »
Evaluating the use of cell phone messaging for community Ebola syndromic surveillance in high risked settings in Southern Sierra Leone.
*Evaluating the use of cell phone messaging for community Ebola syndromic surveillance in high risked settings in Southern Sierra Leone.* Afr Health Sci. 2015 Sep;15(3):797-802 Authors: Jia K, Mohamed K Abstract BACKGROUND: Most underdeveloped countries do not meet core disease outbreak surveillance because of the lack of human resources, laboratory and infrastructural facilities. The use of cell phone technology for disease outbreak syndromic surveillance is a new phenomenon in Sierra Leone despite its successes in other developing countries like Sri Lanka. In this study we set ...περισσότερα »
Computerized Analysis of Acoustic Characteristics of Patients with Internal Nasal Valve Collapse Before and After Functional Rhinoplasty.
Related Articles *Computerized Analysis of Acoustic Characteristics of Patients with Internal Nasal Valve Collapse Before and After Functional Rhinoplasty.* J Med Signals Sens. 2015 Oct-Dec;5(4):210-9 Authors: Rezaei F, Omrani MR, Abnavi F, Mojiri F, Golabbakhsh M, Barati S, Mahaki B Abstract Acoustic analysis of sounds produced during speech provides significant information about the physiology of larynx and vocal tract. The analysis of voice power spectrum is a fundamental sensitive method of acoustic assessment that provides valuable information about the voice source and char... περισσότερα »
Type IV congenital laryngeal web: Case report and 15 year follow up.
Related Articles *Type IV congenital laryngeal web: Case report and 15 year follow up.* Am J Otolaryngol. 2016 Mar-Apr;37(2):148-51 Authors: Sorichetti B, Moxham JP, Kozak FK Abstract A five day old patient with mild VACTERL syndrome had repair of a type IV congenital laryngeal web with successful decannulation 76days later. Voice and respiratory outcome is good with follow up 15years later. This case presents a rare clinical finding of a type IV laryngeal web successfully repaired with a keel and subsequent long term follow up during an era when it was suggested that repair be de... περισσότερα »
Student voice - Join the battle.
Related Articles *Student voice - Join the battle.* Nurs Child Young People. 2016 Mar 8;28(2):14 Authors: Cowen E Abstract BEING A nursing student in the current political climate can be alarming and exhausting. There is an uneasiness in the back of everyone's minds that the NHS is not the institution we thought it was, and that every day a new crack will appear in its foundations. It is as if, brick by brick, the NHS is being slowly dismantled, and the latest brick to be removed is actually a cornerstone: nursing student bursaries. PMID: 26954644 [PubMed - in process] from Spe... περισσότερα »
A Cognitive Neuroscience View of Voice-Processing Abnormalities in Schizophrenia: A Window into Auditory Verbal Hallucinations?
Related Articles *A Cognitive Neuroscience View of Voice-Processing Abnormalities in Schizophrenia: A Window into Auditory Verbal Hallucinations?* Harv Rev Psychiatry. 2016 Mar-Apr;24(2):148-63 Authors: Conde T, Gonçalves OF, Pinheiro AP Abstract Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia. Like "real" voices, AVH carry a rich amount of linguistic and paralinguistic cues that convey not only speech, but also affect and identity, information. Disturbed processing of voice identity, affective, and speech information has been reported in patients with sch... περισσότερα »
Advanced life events (ALEs) that impede aging-in-place among seniors.
Related Articles *Advanced life events (ALEs) that impede aging-in-place among seniors.* Arch Gerontol Geriatr. 2016 May-Jun;64:90-5 Authors: Lindquist LA, Ramirez-Zohfeld V, Sunkara P, Forcucci C, Campbell D, Mitzen P, Cameron KA Abstract Despite the wishes of many seniors to age-in-place in their own homes, critical events occur that impede their ability to do so. A gap exists as to what these advanced life events (ALEs) entail and the planning that older adults perceive is necessary. The purpose of this study was to identify seniors' perceptions and planning toward ALEs that ma...περισσότερα »
Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.
Related Articles *Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.* J Voice. 2016 Mar 4; Authors: Moore J, Greenberg C, Thibeault SL Abstract OBJECTIVE: To evaluate predictors of longitudinal change in patient-perceived voice impact as determined by the Voice Handicap Index (VHI). STUDY DESIGN: Prospective, survey study. METHODS: Patients consented to the University of Wisconsin Voice and Swallow Clinics Outcomes Database with voice, concerns with a baseline clinic visit from November 2012 to January 2014 were eligible for the study. T... περισσότερα »
A Comparative Study of Iranian Female Primary School Teachers' Quality of Life With and Without Voice Complaints.
Related Articles *A Comparative Study of Iranian Female Primary School Teachers' Quality of Life With and Without Voice Complaints.* J Voice. 2016 Mar 4; Authors: Aghadoost O, Moradi N, Aghadoost A, Montazeri A, Soltani M, Saffari A Abstract OBJECTIVES/HYPOTHESIS: As the largest group of professional voice users, teachers are more likely to face voice disorders because of their specific job conditions. This study aimed to compare the quality of life in female teachers with and without voice complaints. STUDY DESIGN: This is a cross-sectional descriptive-analytical study. METHODS: ...περισσότερα »
Screaming for Attention: The Vocal Demands of Actors in Violent Interactive Games.
Related Articles *Screaming for Attention: The Vocal Demands of Actors in Violent Interactive Games.* J Voice. 2016 Mar 4; Authors: Cazden J PMID: 26952319 [PubMed - as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/1nz3TLY
Singers' Vocal Function Knowledge Levels, Sensorimotor Self-awareness of Vocal Tract, and Impact of Functional Voice Rehabilitation on the Vocal Function Knowledge and Self-awareness of Vocal Tract.
Related Articles *Singers' Vocal Function Knowledge Levels, Sensorimotor Self-awareness of Vocal Tract, and Impact of Functional Voice Rehabilitation on the Vocal Function Knowledge and Self-awareness of Vocal Tract.* J Voice. 2016 Mar 4; Authors: Sielska-Badurek E, Osuch-Wójcikiewicz E, Sobol M, Kazanecka E, Niemczyk K Abstract OBJECTIVES/HYPOTHESIS: This study investigated vocal function knowledge and vocal tract sensorimotor self-awareness and the impact of functional voice rehabilitation on vocal function knowledge and self-awareness. STUDY DESIGN: This is a prospective, rando... περισσότερα »
Gender-related aspects of transmasculine people's vocal situations: insights from a qualitative content analysis of interview transcripts.
Related Articles *Gender-related aspects of transmasculine people's vocal situations: insights from a qualitative content analysis of interview transcripts.* Int J Lang Commun Disord. 2016 Mar 8; Authors: Azul D Abstract BACKGROUND: Transmasculine people assigned female gender at birth but who do not identify with this classification have traditionally received little consideration in the voice literature. Existing analyses tend to be focused on evaluating speaker voice characteristics, whereas other factors that contribute to the production of vocal gender have remained underexpl...περισσότερα »
Interactive Voice/Web Response System in clinical research.
Related Articles *Interactive Voice/Web Response System in clinical research.* Perspect Clin Res. 2016 Jan-Mar;7(1):15-20 Authors: Ruikar V Abstract Emerging technologies in computer and telecommunication industry has eased the access to computer through telephone. An Interactive Voice/Web Response System (IxRS) is one of the user friendly systems for end users, with complex and tailored programs at its backend. The backend programs are specially tailored for easy understanding of users. Clinical research industry has experienced revolution in methodologies of data capture with t...περισσότερα »
Generating Tonal Distinctions in Mandarin Chinese Using an Electrolarynx with Preprogrammed Tone Patterns.
Related Articles *Generating Tonal Distinctions in Mandarin Chinese Using an Electrolarynx with Preprogrammed Tone Patterns.* Speech Commun. 2016 Apr 1;78:34-41 Authors: Guo L, Nagle K, Heaton JT Abstract An electrolarynx (EL) is a valuable rehabilitative option for individuals who have undergone laryngectomy, but current monotone ELs do not support controlled variations in fundamental frequency for producing tonal languages. The present study examined the production and perception of Mandarin Chinese using a customized hand-held EL driven by computer software to generate tonal d...περισσότερα »
Development of Vibrational Culture Model Mimicking Vocal Fold Tissues.
Related Articles *Development of Vibrational Culture Model Mimicking Vocal Fold Tissues.* Ann Biomed Eng. 2016 Mar 7; Authors: Kim D, Lim JY, Kwon S Abstract The vocal folds (VFs) are connective tissues with complex matrix structures that provide the required mechanical properties for voice generation. VF injury leads to changes in tissue structure and properties, resulting in reduced voice quality. However, injury-induced biochemical changes and repair in scarred VF tissues have not been well characterized to date. To treat scarred VFs, it is essential to understand how physiolog... περισσότερα »
Tracheoesophageal fistula length decreases over time.
Related Articles *Tracheoesophageal fistula length decreases over time.* Eur Arch Otorhinolaryngol. 2016 Mar 7; Authors: Jiang N, Kearney A, Damrose EJ Abstract The objectives of this study were to demonstrate that the length of the tracheoesophageal voice prosthesis changes over time and to determine whether the prosthesis length over time increased, decreased, or showed no predictable change in size. A retrospective chart review was performed at a tertiary care referral center. Patients who underwent either primary or secondary tracheoesophageal puncture between January 2006 and...περισσότερα »
External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity.
Related Articles *External Validation of the Acoustic Voice Quality Index Version 03.01 With Extended Representativity.* Ann Otol Rhinol Laryngol. 2016 Mar 7; Authors: Barsties B, Maryn Y Abstract OBJECTIVES: The Acoustic Voice Quality Index (AVQI) is an objective method to quantify the severity of overall voice quality in concatenated continuous speech and sustained phonation segments. Recently, AVQI was successfully modified to be more representative and ecologically valid because the internal consistency of AVQI was balanced out through equal proportion of the 2 speech types. ... περισσότερα »
The nature of articulation errors in Egyptian Arabic-speaking children with velopharyngeal insufficiency due to cleft palate.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The nature of articulation errors in Egyptian Arabic-speaking children with velopharyngeal insufficiency due to cleft palate.* Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1527-32 Authors: Abou-Elsaad T, Baz H, Afsah O, Mansy A Abstract UNLABELLED: Even with early surgical repair, the majority of cleft palate children demonstrate articulation errors and have typical cleft palate speech. OBJECTIVE: Was to determine the nature of articulation errors of Arabic consonants in Egyptian Arabic-speaking children with vel... περισσότερα »
speech and language; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *speech and language* These pubmed results were generated on 2016/03/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Speech via xlomafota13 on Inoreader http://ift.tt/1XeFsiW
Pericytes: A newly recognized player in wound healing
Pericytes: A newly recognized player in wound healing: Abstract Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes probably drive much of the vascular involution that occurs during the transition from the regenerative to the resolution phases of healing. Pathologically, pe... περισσότερα »
The Oral Cancer Foundation’s Founder, Brian R. Hill, honored by the Global Oral Cancer Forum – PR Newswire (press release)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
The Oral Cancer Foundation’s Founder, Brian R. Hill, honored by the Global Oral Cancer Forum PR Newswire (press release) NEWPORT BEACH, Calif., March 10, 2016 /PRNewswire-USNewswire/ — At the recent Global Oral Cancer Forum (GOCF), Brian R. Hill, Executive Director and Founder of the Oral Cancer Foundation (OCF), was honored for his work as an […]
It’s still not too late to join us in Buenos Aires tomorrow at our prostate cancer symposium https://t.co/5gt9yg1uGU https://t.co/OGoIcVQJ4W
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
It’s still not too late to join us in Buenos Aires tomorrow at our prostate cancer symposium https://t.co/5gt9yg1uGU https://t.co/OGoIcVQJ4W from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/707883830103900160 via IFTTT
MIT researchers say that glucose isn’t the only fuel for cancer cells. Read the story here: https://t.co/Je10E3Winv https://t.co/3ys2KV3q9O
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
MIT researchers say that glucose isn’t the only fuel for cancer cells. Read the story here: https://t.co/Je10E3Winv https://t.co/3ys2KV3q9O from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/707878072150859777 via IFTTT
EpiCast Report: Head and Neck Cancers – Epidemiology Forecast to 2024 – New Market Research Report – Digital Journal
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
EpiCast Report: Head and Neck Cancers – Epidemiology Forecast to 2024 – New Market Research Report Digital Journal … consisting of cancers of the mouth, including the lip, tongue, gum, floor of mouth, palate, and other parts of mouth; the salivary glands; the pharynx, including the tonsil, oropharynx, nasopharynx, pyriform fossa, hypopharynx, other mouth/pharynx … […]
Induction Chemo Offers No OS Benefit for Locally Advanced Head and Neck Cancer – OncLive
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
OncLive Induction Chemo Offers No OS Benefit for Locally Advanced Head and Neck Cancer OncLive Induction chemotherapy predicts cumulative radiation dose and fails to improve survival in advanced head and neck cancer, a National Cancer Database analysis. Presented at: 2016 Multidisciplinary Head and Neck Cancer Symposium; February 18-20, … and more » from #AlexandrosSfakianakis via […]
Short-term acute effects of gutkha chewing on heart rate variability among young adults: A cross-sectional study.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Short-term acute effects of gutkha chewing on heart rate variability among young adults: A cross-sectional study. Int J Appl Basic Med Res. 2016 Jan-Mar;6(1):45-9 Authors: Itagi AB, Arora D, Patil NA, Bailwad SA, Yunus GY, Goel A Abstract BACKGROUND AND OBJECTIVES: An increase in the consumption of smokeless tobacco has been noticed among high school, […]
Trends in HIV prevalence from 2008 to 2012 among young adults in Port Harcourt, Nigeria.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
Trends in HIV prevalence from 2008 to 2012 among young adults in Port Harcourt, Nigeria. Afr Health Sci. 2015 Sep;15(3):776-88 Authors: Okonko IO, Nnodim LC Abstract BACKGROUND: The pandemic of HIV lines amongst the utmost infectious disease menaces in antiquity. HIV remains a problem worldwide and it’s a grave health snags in developing nations particularly […]
sleep; +101 new citations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 5 δευτερόλεπτα
101 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: sleep These pubmed results were generated on 2016/03/10 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from […]
Long-term radiological findings after endonasal endoscopic approach to the skull base.
Related Articles *Long-term radiological findings after endonasal endoscopic approach to the skull base.* Am J Otolaryngol. 2016 Mar-Apr;37(2):103-7 Authors: Langdon C, Enseñat J, Rioja E, Jaume F, Berenguer J, Oleaga L, Bernal-Sprekelsen M, Alobid I Abstract OBJECTIVE: To study the long-term radiological findings after endonasal endoscopic approach to the skull base. MATERIAL AND METHODS: Prospective study that included 55 patients who underwent advance endoscopic skull base surgery. All patients were evaluated with MRI before, 3months and 12months after surgery. We used the Lu...περισσότερα »
Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.
Related Articles *Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.* Otol Neurotol. 2016 Mar 7; Authors: Zhai F, Wang J, Zhang Y, Dai CF Abstract OBJECTIVE: To investigate the correlation between psychological disorder and vestibular dysfunction in patients suffering from intractable peripheral vertigo. STUDY DESIGN: Prospective study. SETTING: In-patients in a university hospital. METHODS: Prospective design of 26 intractable peripheral vertiginous patients with peripheral vestibular dysfunction and 20 controls rec... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note.
Related Articles *Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note.* Eur Arch Otorhinolaryngol. 2016 Mar 7; Authors: Zeinalizadeh M, Sadrehosseini SM, Barkhoudarian G, Carrau RL Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal s... περισσότερα »
EPHX1 Polymorphisms and the Risk of Head and Neck Cancer
*Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer: Aim * *To evaluate the association between the EPHX1 Tyr113His and His139Arg polymorphisms in the EPHX1 gene and the risk of head and neck cancer.* *Materials and Methods * *Studies on the association of EPHX1 Tyr113His and His139Arg polymorphisms with HNC performed up until June 1st, 2014, were identified using a predefined search strategy. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of these associations.* *... περισσότερα »
Second primary malignancy (SPM) is the major long-term cause of patient mortality with head and neck squamous cell carcinoma (HNSCC)
Metachronous Second Primary Malignancies after Head and Neck Cancer in a Korean Cohort (1993-2010): Abstract Second primary malignancy (SPM) is the major long-term cause of patient mortality with head and neck squamous cell carcinoma (HNSCC). As the incidence of high-risk human papillomavirus (HPV)-related HNSCC is increasing globally, we analyzed the patterns of SPM occurrence, the effect of the index tumor site along with attributes to HPV, and the effect of SPM on survival in South Korean patients with head and neck cancer (HNC). Data were retrieved from the Korea Central Ca...περισσότερα »
The Impact of Iterative Reconstruction on Computed Tomography Radiation Dosimetry: Evaluation in a Routine Clinical Setting
The Impact of Iterative Reconstruction on Computed Tomography Radiation Dosimetry: Evaluation in a Routine Clinical Setting: Purpose To evaluate the effect of introduction of iterative reconstruction as a mandated software upgrade on radiation dosimetry in routine clinical practice over a range of computed tomography examinations. Methods Random samples of scanning data were extracted from a centralised Picture Archiving Communication System pertaining to 10 commonly performed computed tomography examination types undertaken at two hospitals in Western Australia, before and after... περισσότερα »
Radiosensitization in esophageal squamous cell carcinoma
Radiosensitization in esophageal squamous cell carcinoma: Abstract PurposeThis study examined the efficacy of polo-like kinase 1 (PLK1) inhibition on radiosensitivity in vitro and in vivo by a pharmacologic approach using the highly potent PLK1 inhibitor volasertib. Methods and materialsHuman esophageal squamous cell carcinoma (ESCC) cell lines KYSE 70 and KYSE 150 were used to evaluate the synergistic effect of volasertib and irradiation in vitro using cell viability assay, colony formation assay, cell cycle phase analysis, and western blot, and in vivo using ectopic tumor mod... περισσότερα »
Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Jamie A. Dean, Liam C. Welsh, Dualta McQuaid, Kee H. Wong, Aleksandar Aleksic, Emma Dunne, Mohammad R. Islam, Anushka Patel, Priyanka Patel, Imran Petkar, Iain Phillips, Jackie Sham, Kate L. Newbold, Shreerang A. Bhide, Kevin J. Harrington, Sarah L. Gulliford, Christopher M. Nutting Background and purposeCurrent oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of... περισσότερα »
Adjuvant radiation therapy in resected high-grade localized skeletal osteosarcomas treated with neoadjuvant chemotherapy: Long-term outcomes
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Claudio V. Sole, Felipe A. Calvo, Eduardo Alvarez, Mauricio Cambeiro, Miguel Cuervo, Mikel San Julian, Sebastian Sole, Rafael Martinez-Monge, Luis Sierrasesumaga PurposeTo assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas.Methods and materialsSeventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to Dece... περισσότερα »
Long-term radiological findings after endonasal endoscopic approach to the skull base.
Related Articles *Long-term radiological findings after endonasal endoscopic approach to the skull base.* Am J Otolaryngol. 2016 Mar-Apr;37(2):103-7 Authors: Langdon C, Enseñat J, Rioja E, Jaume F, Berenguer J, Oleaga L, Bernal-Sprekelsen M, Alobid I Abstract OBJECTIVE: To study the long-term radiological findings after endonasal endoscopic approach to the skull base. MATERIAL AND METHODS: Prospective study that included 55 patients who underwent advance endoscopic skull base surgery. All patients were evaluated with MRI before, 3months and 12months after surgery. We used the Lu...περισσότερα »
Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.
Related Articles *Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.* Otol Neurotol. 2016 Mar 7; Authors: Zhai F, Wang J, Zhang Y, Dai CF Abstract OBJECTIVE: To investigate the correlation between psychological disorder and vestibular dysfunction in patients suffering from intractable peripheral vertigo. STUDY DESIGN: Prospective study. SETTING: In-patients in a university hospital. METHODS: Prospective design of 26 intractable peripheral vertiginous patients with peripheral vestibular dysfunction and 20 controls rec... περισσότερα »
Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note.
Related Articles *Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note.* Eur Arch Otorhinolaryngol. 2016 Mar 7; Authors: Zeinalizadeh M, Sadrehosseini SM, Barkhoudarian G, Carrau RL Abstract The nasoseptal flap provides hearty vascularized tissue for the reconstruction of skull base defects subsequent to expanded endonasal approaches; however, it leads to exposure of the cartilage at the septal donor site producing crusting and discomfort while it remucosalizes. We report an alternative technique to reconstruct the denuded nasal s... περισσότερα »
Anaesthesia and Sedation For Electrocochleography.
Related Articles *Anaesthesia and Sedation For Electrocochleography.* Acta Otolaryngol. 1974 Jan;77 Suppl 316:37-8 Authors: Zvonar M, Zvonar-Kuhndl B, Odenthal DW Abstract Anaesthesia and sedation in electrocochleo-graphy are of paramount importance for the whole procedure, since restlessness of the patient during the measurements can invalidate the results of the test. The time needed for extensive electrocochleography amounts on average to two hours. The only pain experienced during the procedure is associated with the placement of the transtympanic electrode. A relatively long...περισσότερα »
Methods for assessing high frequency hearing loss in every-day listening situations.
Related Articles *Methods for assessing high frequency hearing loss in every-day listening situations.* Acta Otolaryngol. 1974 Jan;77(320):1-50 Authors: Gunnar A PMID: 26947520 [PubMed] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UUV2l8 via IFTTT
Scanning Electron Microscopy of the Inner Structure of the Organ of Corti and its Neural Pathways.
Related Articles *Scanning Electron Microscopy of the Inner Structure of the Organ of Corti and its Neural Pathways.* Acta Otolaryngol. 1974 Jan;77(319):57-66 Authors: Engström B Abstract Scanning electron microscopy has been used by the author since 1968 and has become an important tool in the study of inner ear structures. By the combination of good preparation and microdissection, light and electron microscopy, we can better visualize the structure of the normal and pathologically altered organ of Corti and also the vestibular sensory regions. In the present publication it is... περισσότερα »
The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.
Related Articles *The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.* Acta Otolaryngol. 1974 Jan;77(319):43-56 Authors: Angelborg C, Engström B Abstract The tympanic covering layer in guinea pig was studied with transmission and scanning electron microscopy. The tympanic border cells looked like bipolar ganglion cells with long processes. There was often a kinocilium on the cell body. The cells were rather similar structurally but their arrangement varied in the different coils. In the basal coil the cells were lying close together and oriented strictly lon... περισσότερα »
Distribution of Macromolecular Tracer Particles (Thorotrast(R)) in the Cochlea. An Electron Microscopic Study in Guinea Pig: Part I. The organ of Corti, the basilar membrane and the tympanic covering layer.
Related Articles *Distribution of Macromolecular Tracer Particles (Thorotrast(R)) in the Cochlea. An Electron Microscopic Study in Guinea Pig: Part I. The organ of Corti, the basilar membrane and the tympanic covering layer.* Acta Otolaryngol. 1974 Jan;77(319):19-41 Authors: Angelborg C Abstract Thorotrast(R) containing thorium dioxide particles with diameters of around 100 Å was introduced in perilymph or endolymph using various methods and concentrations. The location of the tracer particles in the cochleas was determined using the transmission electron microscope. Injection of... περισσότερα »
Surface Structures of the Human Vestibular Sensory Regions.
Related Articles *Surface Structures of the Human Vestibular Sensory Regions.* Acta Otolaryngol. 1974 Jan;77(319):3-18 Authors: Rosenhall U, Engström B Abstract The hair bundles and other surface organelles of the human vestibular sensory regions have been studied with SEM and TEM. The material was taken from individuals of different ages, from the fetal period to old age. The hair bundles have a remarkably mature appearance in fetuses three to four months old. Each hair bundle consists of one kinocilium and of many stereocilia of different length. Some hair bundles are shorter t... περισσότερα »
Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.
Related Articles *Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.* J Voice. 2016 Mar 4; Authors: Moore J, Greenberg C, Thibeault SL Abstract OBJECTIVE: To evaluate predictors of longitudinal change in patient-perceived voice impact as determined by the Voice Handicap Index (VHI). STUDY DESIGN: Prospective, survey study. METHODS: Patients consented to the University of Wisconsin Voice and Swallow Clinics Outcomes Database with voice, concerns with a baseline clinic visit from November 2012 to January 2014 were eligible for the study. ...περισσότερα »
Alcohol responsiveness in laryngeal dystonia: a survey study.
[image: http:--production.springer.de-OnlineReso] Related Articles *Alcohol responsiveness in laryngeal dystonia: a survey study.* J Neurol. 2015 Jun;262(6):1548-56 Authors: Kirke DN, Frucht SJ, Simonyan K Abstract Laryngeal dystonia (LD) is a task-specific focal dystonia of unknown pathophysiology affecting speech production. We examined the demographics of anecdotally reported alcohol use and its effects on LD symptoms using an online survey based on Research Electronic Data Capture (REDCap™) and National Spasmodic Dysphonia Association's patient registry. From 641 participants... περισσότερα »
Tinnitus: Is there a place for brain stimulation?
*Tinnitus: Is there a place for brain stimulation?* Surg Neurol Int. 2016;7(Suppl 4):S125-9 Authors: van Zwieten G, Smit JV, Jahanshahi A, Temel Y, Stokroos RJ Abstract Tinnitus is the perception of a "phantom sound" and has a high prevalence. Although many therapies have been investigated within the last decades, there is still no effective standard therapy. Animal studies and human functional imaging studies revealed that tinnitus perception is associated with many complex changes in multiple brain structures. There is growing evidence that brain stimulation might be able to int... περισσότερα »
Disability evaluation in acoustic blast trauma.
*Disability evaluation in acoustic blast trauma.* Indian J Occup Environ Med. 2015 Sep-Dec;19(3):138-40 Authors: Raju G Abstract INTRODUCTION: Acoustic blast trauma is different from Noise induced hearing loss. Blast trauma can damage the tympanic membrane, ossicles and cochlea singly or in combination. It produces immediate severe hearing loss and may be associated with tinnitus and vestibular symptoms. Hearing loss recovers spontaneously in many cases but may be permanent in 30-55% cases. Thirteen patients working in an explosive manufacturing unit in Andhra Pradesh were expose...περισσότερα »
Emerging hubs in phantom perception connectomics.
Related Articles *Emerging hubs in phantom perception connectomics.* Neuroimage Clin. 2016;11:181-94 Authors: Mohan A, De Ridder D, Vanneste S Abstract Brain networks are small-world networks typically characterized by the presence of hubs, i.e. nodes that have significantly greater number of links in comparison to other nodes in the network. These hubs act as short cuts in the network and promote long-distance connectivity. Long-distance connections increase the efficiency of information transfer but also increase the cost of the network. Brain disorders are associated with an ... περισσότερα »
Efficacy of balloon dilation in the treatment of symptomatic Eustachian tube dysfunction: One year follow-up study.
Related Articles *Efficacy of balloon dilation in the treatment of symptomatic Eustachian tube dysfunction: One year follow-up study.* Am J Otolaryngol. 2016 Mar-Apr;37(2):99-102 Authors: Xiong H, Liang M, Zhang Z, Xu Y, Ou Y, Chen S, Yang H, Zheng Y Abstract PURPOSE: Eustachian tube balloon dilation (ETBD) has been recently described as feasible treatment for patients with refractory Eustachian tube dysfunction (ETD). The aim of this study was to evaluate the efficacy of ETBD in the treatment of symptomatic Eustachian tube dysfunction (SETD) by subjective and objective analysis.... περισσότερα »
SENP1 but not fetal hemoglobin differentiates chronic mountain sickness from healthy Andean highlanders.
Related Articles *SENP1 but not fetal hemoglobin differentiates chronic mountain sickness from healthy Andean highlanders.* Exp Hematol. 2016 Mar 4; Authors: Hsieh MM, Callacondo D, Rojas-Camayo J, Quesada-Olarte J, Wang X, Uchida N, Maric I, Remaley AT, Leon-Velarde F, Villafuerte FC, Tisdale JF Abstract Chronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized modest increases in fetal hemoglobin (HbF) is associated with lower CMS severity. In this cross-sectional study, we showed that normal HbF levels (med... περισσότερα »
Myeloid sarcoma: An unusual and rare laryngeal presentation.
*Myeloid sarcoma: An unusual and rare laryngeal presentation.* Int J Surg Case Rep. 2016 Feb 21;21:99-103 Authors: Tan SN, Gendeh HS, Sani A, Mat-Baki M Abstract INTRODUCTION: Myeloid Sarcoma (MS) or Granulocytic Sarcoma is an uncommon laryngeal malignancy. It may arise from myelodysplastic syndromes, malignancy or de novo. Presentation in the larynx is rare and some may present with Acute Myeloid Leukaemia (AML) whereby the later may be asymptomatic. CASE PRESENTATION: A 44-year-old South East Asian lady presented with a six months history of hoarseness, shortness of breath, redu... περισσότερα »
Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial.
*Paracetamol 325 mg/tramadol 37.5 mg effect on pain during needle electromyography: a double-blind crossover clinical trial.* Acta Neurol Belg. 2016 Mar 8; Authors: Kalantar SS, Abbasi M, Faghihi-Kashani S, Majedi H, Ahmadi M, Agah E, Tafakhori A Abstract Needle insertion during electromyography (EMG) may cause varying levels of pain that could lead to inaccurate assessment and premature termination of the procedure. The aim of this study is to compare paracetamol 325 mg/tramadol 37.5 mg with placebo in relieving pain before EMG. This is a randomized, crossover, placebo-controlle...περισσότερα »
Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.
Related Articles *Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.* Otol Neurotol. 2016 Mar 7; Authors: Zhai F, Wang J, Zhang Y, Dai CF Abstract OBJECTIVE: To investigate the correlation between psychological disorder and vestibular dysfunction in patients suffering from intractable peripheral vertigo. STUDY DESIGN: Prospective study. SETTING: In-patients in a university hospital. METHODS: Prospective design of 26 intractable peripheral vertiginous patients with peripheral vestibular dysfunction and 20 controls recr... περισσότερα »
Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway
Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway: Abstract BackgroundThere is growing evidence that Bit1 exerts different roles in the development and progression of human cancers. Although Bit1 was highly exhibited in ESCC tissues in our previous study, its roles and molecular mechanisms implicated in development and progression of ESCC remain unknown. MethodsBit1 protein expression in ESCC cell lines and normal esophageal epithelial cell was d...περισσότερα »
Introduction – Beckett, Medicine and the Brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pa2750 via IFTTT
Introduction – Beckett, Medicine and the Brain
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1pa2750 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Optimized total thoracoscopic and laparoscopic esophagectomy for esophageal cancer
Optimized total thoracoscopic and laparoscopic esophagectomy for esophageal cancer: Abstract BackgroundTotal thoracoscopic and laparoscopic esophagectomy (TLE) has attracted attention with the advantage of better operative field and minimal wound for the esophageal cancer. However, various severe complications are also reported during the TLE such as cervical anastomotic leakage, chylothorax, and tracheal injury. The aim of this study was to introduce a new optimized TLE procedure for the esophageal cancer and assess its safety and clinical effects. MethodsWe retrospectively c...περισσότερα »
Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.
*Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.* Oncotarget. 2016 Mar 4; Authors: Atiq R, Hertz R, Eldad S, Smeir E, Bar-Tana J Abstract B-Raf(V600E) activates MEK/MAPK signalling and acts as oncogenic driver of a variety of cancers, including melanoma, colorectal and papillary thyroid carcinoma. Specific B-Raf(V600E) kinase inhibitors (e.g., Vemurafenib) prove initial efficacy in melanoma followed shortly by acquired resistance, while failing in most other B-Raf(V600E) cancers due to primary resistance. Resistance is due to acquired mutations in the Ras/Raf/MEK/MAP...περισσότερα »
Radiation therapy generates platelet-activating factor agonists.
*Radiation therapy generates platelet-activating factor agonists.* Oncotarget. 2016 Mar 3; Authors: Sahu RP, Harrison KA, Weyerbacher J, Murphy RC, Konger RL, Garrett JE, Chin-Sinex HJ, Johnston Ii ME, Dynlacht JR, Mendonca M, McMullen K, Li G, Spandau DF, Travers JB Abstract Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the present studies were designed to define whether ionizing radiation could generate PAF-... περισσότερα »
The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murray paniculata to safe and effective cancer metastatic chemopreventives.
*The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murray paniculata to safe and effective cancer metastatic chemopreventives.* Oncotarget. 2016 Mar 5; Authors: Jiang Z, Pang Y, Yu X, Zhou S, Qian J, Zheng N, Dong H, Shi Q, Kuo M, Jia L Abstract Recent large epidemiological studies demonstrated benefit of oral contraceptives in reducing cancer risk, and our analysis also showed molecular and cellular similarities between embryo implantation and CTCs adhesion-invasion to endothelium. We here hypothesize that abortion traditional Chinese medic...περισσότερα »
Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.
*Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.* Oncotarget. 2016 Mar 4; Authors: Atiq R, Hertz R, Eldad S, Smeir E, Bar-Tana J Abstract B-Raf(V600E) activates MEK/MAPK signalling and acts as oncogenic driver of a variety of cancers, including melanoma, colorectal and papillary thyroid carcinoma. Specific B-Raf(V600E) kinase inhibitors (e.g., Vemurafenib) prove initial efficacy in melanoma followed shortly by acquired resistance, while failing in most other B-Raf(V600E) cancers due to primary resistance. Resistance is due to acquired mutations in the Ras/Raf/MEK/MAP...περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
Histiocytosis with mixed cell populations
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1p9VQX3 via IFTTT
Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies
Abstract Background Mycosis fungoides/Sézary syndrome (MF/SS) often requires multiple skin biopsies for definitive diagnosis. *In-vivo* reflectance confocal microscopy (RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/SS using RCM and to correlate RCM features with histopathology and T-cell receptor (TCR) gene rearrangement studies. Methods A cohort of patients with active/recurrent or suspicious MF/SS disease was prospectively recruited for RCM imaging and histopathologic/RCM images were evalu... περισσότερα »
Pericytes: A newly recognized player in wound healing
Abstract Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes probably drive much of the vascular involution that occurs during the transition from the regenerative to the resolution phases of healing. Pathologically, pericytes can assume a fibrotic phenotype and promote sc... περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Is a Wider Margin (2 cm vs. 1 cm) for a 1.01-2.0 mm Melanoma Necessary?
*Is a Wider Margin (2 cm vs. 1 cm) for a 1.01-2.0 mm Melanoma Necessary?* Ann Surg Oncol. 2016 Mar 8; Authors: Doepker MP, Thompson ZJ, Fisher KJ, Yamamoto M, Nethers KW, Harb JN, Applebaum MA, Gonzalez RJ, Sarnaik AA, Messina JL, Sondak VK, Zager JS Abstract BACKGROUND: The current NCCN recommendation for resection margins in patients with melanomas between 1.01 and 2 mm deep is a 1-2 cm radial margin. We sought to determine whether margin width had an impact on local recurrence (LR), disease-specific survival (DSS), and type of wound closure. METHODS: Melanomas measuring 1.01-2.0... περισσότερα »
PRIMARY MALIGNANT AMELANOTIC MELANOMA ARISING FROM A VITILIGO PATCH OF AN AFRICAN TANZANIAN: CASE REPORT.
Related Articles *PRIMARY MALIGNANT AMELANOTIC MELANOMA ARISING FROM A VITILIGO PATCH OF AN AFRICAN TANZANIAN: CASE REPORT.* East Afr Med J. 2014 May;91(5):178-80 Authors: Kiprono SK, Mavura DR, Masenga EJ, Möhrle M, Metzler G Abstract Skin cancer is rare in people of African origin while vitiligo occurs worldwide. The occurrence of primary malignant melanoma and vitiligo together is very rare. We present a rare case of primary malignant amelanotic melanoma arising from a depigmented patch of a patient with vitiligo. It was completely excised and followed for one year. No recurr... περισσότερα »
A clinicopathological analysis of primary mucosal malignant melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *A clinicopathological analysis of primary mucosal malignant melanoma.* Surg Today. 2015 Jul;45(7):886-91 Authors: Izumi D, Ishimoto T, Yoshida N, Nakamura K, Kosumi K, Tokunaga R, Sugihara H, Sawayama H, Karashima R, Imamura Y, Ida S, Hiyoshi Y, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Watanabe M, Baba H Abstract PURPOSES: Primary mucosal malignant melanoma (PMMM) is a rare and highly lethal neoplasm associated with a poor prognosis. CXC chemokine receptor 4 (CXCR4) is expressed on various tumor cells, including...περισσότερα »
The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk-based classification scheme
The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk-based classification scheme: BACKGROUND Fine-needle aspiration cytology (FNAC) has proven its value as an essential step in the diagnosis of salivary gland lesions. Although the majority of salivary gland lesions, especially those that are common and benign, can be diagnosed with ease on FNAC, limited cellularity and morphologic lesion heterogeneity can pose diagnostic challenges and lead to false-positive and false-negative diagnoses. This study presents the institutional exp...περισσότερα »
The importance of margins in head and neck cancer
The importance of margins in head and neck cancer: An estimated 200,000 deaths each year worldwide are due to cancer of the head and neck, mostly mucosal squamous cell carcinoma and nonmelanoma skin cancer. The status of surgical margins is important for prognosis and need for adjuvant therapy. We will discuss how margin status impacts outcomes and therapy, and the conundrum of determining margin status. *J. Surg. Oncol*. © 2015 Wiley Periodicals, Inc.
Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer
Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy-Induced Nausea and Vomiting in Children With Cancer: [image: cover.gif?v=1&s=7acfb7e44176aba29f1596f6] This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy-induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence-based interventions for the treatment of breakthrough and prophylaxis of refractory CIN...περισσότερα »
Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk
Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk: [image: gr1.sml] Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to improve these models, but is resource intensive. We developed and evaluated fully-automated atlas-based segmentation (ABS) of a novel delineation technique for the oral mucosal surfaces.
Adenosine can thwart antitumor immune responses elicited by radiotherapy
Adenosine can thwart antitumor immune responses elicited by radiotherapy: Abstract BackgroundBy studying the bioenergetic status we could show that the development of tumor hypoxia is accompanied, apart from myriad other biologically relevant effects, by a substantial accumulation of adenosine (ADO). ADO has been shown to act as a strong immunosuppressive agent in tumors by modulating the innate and adaptive immune system. In contrast to ADO, standard radiotherapy (RT) can either stimulate or abrogate antitumor immune responses. Herein, we present ADO-mediated mechanisms that may ... περισσότερα »
miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors
miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors: Abstract BackgroundThe postoperative typing of thyroid lesions, which is instrumental in adequate patient treatment, is currently based on histologic examination. However, it depends on pathologist’s qualification and can be difficult in some cases. Numerous studies have shown that molecular markers such as microRNAs and somatic mutations may be useful to assist in these cases, but no consensus exists on the set of marker... περισσότερα »
PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations.
Related Articles *PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations.* Cancer Biol Ther. 2016 Mar 8;:0 Authors: Ji M, Liu Y, Li Q, Li X, Ning Z, Zhao W, Shi H, Jiang J, Wu C Abstract This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 and PD-L1 expressions were detected by immunohistochemistry in 100 surgically resected lung adenocarcinoma tissues and were statistically correlated with clinicopathological characteristics including EGFR and...περισσότερα »
Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.
*Suppression of B-Raf(V600E) cancers by MAPK hyper-activation.* Oncotarget. 2016 Mar 4; Authors: Atiq R, Hertz R, Eldad S, Smeir E, Bar-Tana J Abstract B-Raf(V600E) activates MEK/MAPK signalling and acts as oncogenic driver of a variety of cancers, including melanoma, colorectal and papillary thyroid carcinoma. Specific B-Raf(V600E) kinase inhibitors (e.g., Vemurafenib) prove initial efficacy in melanoma followed shortly by acquired resistance, while failing in most other B-Raf(V600E) cancers due to primary resistance. Resistance is due to acquired mutations in the Ras/Raf/MEK/MAP...περισσότερα »
Prognostic Value of the Number of Retrieved Lymph Nodes in Pathological Nx or N0 Classical Papillary Thyroid Carcinoma.
Related Articles *Prognostic Value of the Number of Retrieved Lymph Nodes in Pathological Nx or N0 Classical Papillary Thyroid Carcinoma.* World J Surg. 2016 Mar 7; Authors: Sung TY, Yoon JH, Song DE, Lee YM, Kim TY, Chung KW, Kim WB, Shong YK, Hong SJ Abstract BACKGROUND: This study evaluated the clinical implications of the number of retrieved central lymph nodes (LN) for the recurrence and recurrence-free survival (RFS) outcomes in patients with pathological Nx (pNx) or N0 classical papillary thyroid carcinoma (PTC). METHODS: In total, 464 patients were enrolled following tota...περισσότερα »
Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.
*Lu-177 labelled peptide treatment for radioiodine refractory differentiated thyroid carcinoma.* BMJ Case Rep. 2016;2016 Authors: Elboğa U, Özkaya M, Sayiner ZA, Çelen YZ Abstract Differentiated thyroid carcinoma (DTC) has good prognosis but 5% of the patients already have distant metastasis at the diagnosis. Tumour cells can lose their iodine uptake ability and enter a state of dedifferentiation. Treatment for differentiated thyroid carcinoma that is not suitable for the local surgery and unresponsive to radioactive iodine uptake is not always easy for physicians. We present a c... περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Inter-observer Variation in the Pathologic Identification of Minimal Extrathyroidal Extension in Papillary Thyroid Carcinoma.
Related Articles *Inter-observer Variation in the Pathologic Identification of Minimal Extrathyroidal Extension in Papillary Thyroid Carcinoma.* Thyroid. 2016 Mar 7; Authors: Su HK, Wenig B, Haser GC, Rowe ME, Asa SL, Baloch ZW, Du E, Faquin WC, Giordano TJ, Ghossein R, LiVolsi VA, Lloyd RV, Mete O, Ozbek U, Rosai J, Fellegara G, Suster S, Thompson LD, Turk A, Urken ML Abstract BACKGROUND: Extrathyroidal extension (ETE) is a significant prognostic factor in papillary thyroid carcinoma (PTC). Minimal extrathyroidal extension (mETE) is characterized by involvement of the sternothyr...περισσότερα »
CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases.
Related Articles *CT and MR imaging of thyroid carcinoma showing thymus-like differentiation (CASTLE): a report of ten cases.* Br J Radiol. 2016 Mar 8;:20150726 Authors: Wu B, Sun T, Gu Y, Peng W, Wang Z, Bi R, Ji Q Abstract OBJECTIVE: To study the CT and MR imaging features of carcinoma showing thymus-like differentiation (CASTLE) and to raise awareness of this rare thyroid tumour. METHODS: The imaging appearances of 10 CASTLE tumours confirmed by surgical pathology were retrospectively reviewed and correlated with clinical and histological findings. RESULTS: Seven patients with... περισσότερα »
Utility of Fine-Needle Aspiration Biopsy in the Evaluation of Pediatric Head and Neck Masses.
*Utility of Fine-Needle Aspiration Biopsy in the Evaluation of Pediatric Head and Neck Masses.* Otolaryngol Head Neck Surg. 2016 Mar 8; Authors: Huyett P, Monaco SE, Choi SS, Simons JP Abstract OBJECTIVES: Fine-needle aspiration biopsy (FNAB) has a well-established role in the evaluation of an adult head and neck mass (HNM) but remains underused in children. The objectives of this study were to assess the diagnostic accuracy, safety profile, use of anesthesia, and influence on surgical decision making of FNAB of HNM in the pediatric population. STUDY DESIGN: Case series with chart... περισσότερα »
MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
*MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2.* Oncotarget. 2016 Mar 4; Authors: Shao Y, Li P, Zhu ST, Yue JP, Ji XJ, Ma D, Wang L, Wang YJ, Zong Y, Wu YD, Zhang ST Abstract The altered expression of miRNAs is involved in carcinogenesis of esophageal squamous cell carcinoma (ESCC), but whether miRNAs regulate COX-2 expression in ESCC is not clear. To this end, the expression levels of miR-26a and miR-144 in ESCC clinical tissues and cell lines were investigated by qRT-PCR. COX-2 and PEG2 were quantified... περισσότερα »
A short-term increase of the postoperative naturally circulating dendritic cells subsets in flurbiprofen-treated patients with esophageal carcinoma undergoing thoracic surgery.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
*A short-term increase of the postoperative naturally circulating dendritic cells subsets in flurbiprofen-treated patients with esophageal carcinoma undergoing thoracic surgery.* Oncotarget. 2016 Feb 24; Authors: Wang D, Yang XL, Chai XQ, Shu SH, Zhang XL, Xie YH, Wei X, Wu YJ, Wei W Abstract The present study evaluated whether flurbiprofen increased the naturally circulating dendritic cells (DCs) subsets in patients with esophageal squamous cell carcinoma (ESCC) undergoing esophageal resection. Compared to healthy donors (n=20), the significantly depressed percentages of plasma...περισσότερα »
Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Related Articles *Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma.* Radiother Oncol. 2016 Mar 4; Authors: Hong A, Zhang X, Jones D, Veillard AS, Zhang M, Martin A, Lyons JG, Lee CS, Rose B Abstract BACKGROUND AND PURPOSE: This study aimed to examine the rate and type of p53 mutation in oropharyngeal cancer (OSCC). Relationships were sought between human papillomavirus (HPV) status and p53 mutation. The role of p53 mutation as a prognostic factor independent of HPV status and as a modifier of the effect of HPV on outcomes was al... περισσότερα »
Early and Severe Radiation Esophagitis Associated With Concurrent Sirolimus
*Early and Severe Radiation Esophagitis Associated With Concurrent Sirolimus [DIAGNOSIS IN ONCOLOGY]: * *[image: F1.small.gif]* *1. Adil S. Akthar, 2. Daniel W. Golden⇑, 3. Rita Nanda, 4. Manish R. Sharma,5. Helen S. Te, 6. K. Gautham Reddy, 7. Xuefeng Zhang and 8. Renuka Malik* *-**Author Affiliations* 1. *Pritzker School of Medicine, University of Chicago, Chicago, IL* 1. *Corresponding author: Daniel W. Golden, MD, Department of Radiation and Cellular Oncology, University of Chicago Medicine, 5758 South Maryland Ave, MC 9006, Chicago, IL 60637; e-ma... περισσότερα »
Breast Cancer Risk in Childhood Cancer Survivors Without a History of Chest Radiotherapy: A Report From the Childhood Cancer Survivor Study [Pediatric Oncology]
Breast Cancer Risk in Childhood Cancer Survivors Without a History of Chest Radiotherapy: A Report From the Childhood Cancer Survivor Study [Pediatric Oncology]: Purpose Little is known about the breast cancer risk among childhood cancer survivors who did not receive chest radiotherapy. We sought to determine the magnitude of risk and associated risk factors for breast cancer among these women. Patients and Methods We evaluated cumulative breast cancer risk in 3,768 female childhood cancer survivors without a history of chest radiotherapy who were participants in the Childhood Can...περισσότερα »
The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study
The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study: Abstract We explored the ability of local and systemic applications of boric acid (BA) to reduce the numbers of methicillin-resistant Staphylococcus aureus (MRSA) in a rat model of tibial osteomyelitis (OM), and compared boric acid… Continue reading The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study
JCDD, Vol. 3, Pages 9: TLR-4 and CD14 Genotypes and Soluble CD14: Could They Predispose to Coronary Atherosclerosis?
Background: Inflammatory mechanisms are key to the pathogenesis of atherosclerosis. Functional polymorphisms of TLR-4, Asp299Gly and Thr399Ile, CD14 promoter area C260T polymorphism and plasma levels of soluble CD14 are studied in subjects with Coronary Artery Disease (CAD). Methods: DNA was obtained from 100 human paraffin-embedded aortic specimens, from cadavers with known coronary atheromatosis (Group A)… Continue reading JCDD, Vol. 3, Pages 9: TLR-4 and CD14 Genotypes and Soluble CD14: Could They Predispose to Coronary Atherosclerosis?
Nasal CD56 positive small round cell tumors
Virchows Arch. Nasal CD56 positive small round cell tumors. Differential diagnosis of hematological, neurogenic, and myogenic neoplasms. Liu Q1, Ohshima K, Sumie A, Suzushima H, Iwasaki H, Kikuchi M. Author information 1Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan. Abstract CD56-positive nasal and nasal-type natural killer (NK)/T-cell lymphoma is… Continue reading Nasal CD56 positive small round cell tumors
CD56-positive solid tumors : acute and chronic myeloid leukaemia, ovarian sex cord-stromal tumours, Wilms’ tumor, neuroblastoma and ga nglioneuroblastoma, phaeochromocytoma/paraganglioma, astrocytoma, oligodendroglioma, ependymoma, meningioma, schwannoma, synovial sarcoma, mesenchymal chondrosarcoma, osteosarcoma, rhabdomyosarcoma, leiomyomatous tumours (except vascular types), and desmoplastic small cell tumour.
Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors: Summary Background IMGN901 is a CD56-targeting antibody-drug conjugate designed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and preliminary activity of IMGN901 in patients with CD56-expressing solid tumors. Methods Patients were… Continue reading CD56-positive solid tumors : acute and chronic myeloid leukaemia, ovarian sex cord-stromal tumours, Wilms’ tumor, neuroblastoma and g... περισσότερα »
Industria farmaceutica, il biotech campano al Science to Market di Francoforte – Il Denaro (Comunicati Stampa) (Blog)
Industria farmaceutica, il biotech campano al Science to Market di Francoforte Il Denaro (Comunicati Stampa) (Blog) … biomateriali e farmaci innovativi per la diagnosi e per la terapia dell’ischemia cerebrale e dei tumori plurifarmacoresistenti della testa, del collo e della mammella attraverso la realizzazione di una rete di biobanche, è presente a Francoforte … from… Continue reading Industria farmaceutica, il biotech campano al Science to Market di Francoforte – Il Denaro (Comunicati Stampa) (Blog)
The Oral Cancer Foundation’s Founder, Brian R. Hill, honored by the Global Oral Cancer Forum – PR Newswire (press release)
The Oral Cancer Foundation’s Founder, Brian R. Hill, honored by the Global Oral Cancer Forum PR Newswire (press release) NEWPORT BEACH, Calif., March 10, 2016 /PRNewswire-USNewswire/ — At the recent Global Oral Cancer Forum (GOCF), Brian R. Hill, Executive Director and Founder of the Oral Cancer Foundation (OCF), was honored for his work as an… Continue reading The Oral Cancer Foundation’s Founder, Brian R. Hill, honored by the Global Oral Cancer Forum – PR Newswire (press release)
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.: Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates.… Continue reading Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
It’s still not too late to join us in Buenos Aires tomorrow at our prostate cancer symposium https://t.co/5gt9yg1uGU https://t.co/OGoIcVQJ4W
It’s still not too late to join us in Buenos Aires tomorrow at our prostate cancer symposium https://t.co/5gt9yg1uGU https://t.co/OGoIcVQJ4W from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/707883830103900160 via IFTTT
A comprehensive approach to the prevention of central venous catheter complications: results of 10-year prospective surveillance in pediatric hematology-oncology patients
A comprehensive approach to the prevention of central venous catheter complications: results of 10-year prospective surveillance in pediatric hematology-oncology patients: Abstract We report our decennial experience with 1161 newly-placed long-term central venous catheters inserted in 919 hematology-oncology patients for a total of 413,901 CVC-days of observation. Most of the CVCs were partially-implanted, open-ended, Broviac-Hickman type… Continue reading A comprehensive approach to the prevention of central venous catheter complications: results of 10-year prospective surveillance... περισσότερα »
MIT researchers say that glucose isn’t the only fuel for cancer cells. Read the story here: https://t.co/Je10E3Winv https://t.co/3ys2KV3q9O
MIT researchers say that glucose isn’t the only fuel for cancer cells. Read the story here: https://t.co/Je10E3Winv https://t.co/3ys2KV3q9O from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/707878072150859777 via IFTTT
Presynaptic BK channels control transmitter release: Physiological relevance and potential therapeutic implications
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
Abstract BK channels are large conductance potassium channels characterized by four pore-forming α subunits, often co-assembled with auxiliary β and γ subunits to regulate Ca2+ sensitivity, voltage dependence and gating properties. Abundantly expressed in the CNS, they have the peculiar characteristic of being activated by both voltage and intracellular calcium rise. The increase in intracellular calcium *via* voltage-dependent calcium channels (Cav) during spiking triggers conformational changes and BK channel opening. This narrows the action potential and induces a fast after-hy...περισσότερα »
Framing the grid: Effect of boundaries on grid cells and navigation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 17 δευτερόλεπτα
Abstract Cells in the mammalian hippocampal formation subserve neuronal representations of environmental location and support navigation in familiar environments. Grid cells constitute one of the main cell types in the hippocampal formation and are widely believed to represent a universal metric of space independent of external stimuli. Recent evidence showing that grid symmetry is distorted in non-symmetrical environments suggests that a re-examination of this hypothesis is warranted. In this review we will discuss behavioural and physiological evidence for how environmental sha... περισσότερα »
The role of molecular testing in soft tissue sarcoma diagnosis
[Comment] The role of molecular testing in soft tissue sarcoma diagnosis: [image: fx1.sml] What is the true fidelity of the expert human eye and brain in affirming an accurate sarcoma diagnosis? The study by Antoine Italiano and colleagues1 aims to answer this question by linking diagnoses made by sarcoma experts to molecular genetic testing done with fluorescence in-situ hybridisation (FISH), PCR, or reverse transcriptase-PCR for six soft tissue sarcoma subtypes. This level IV diagnostic and therapeutic study included 384 patients at 32 centres managed by the French Sarcoma Gro...περισσότερα »
Managing Liposarcomas
Managing Liposarcomas: Cutting Through the Fat [Clinical Reviews]: Liposarcomas are one of the most common of more than 50 histologic subtypes of soft tissue sarcomas that, themselves, are heterogeneous. Liposarcomas fall into four distinct histologic subtypes: atypical lipomatous tumor/well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid (round cell) liposarcoma, and pleomorphic liposarcoma. Definitive treatment remains surgical resection with negative margins for resectable disease. However, well-differentiated liposarcomas that are large or difficult to operate ... περισσότερα »
The Promise and Burden of Peer Review in Radiation Oncology
The Promise and Burden of Peer Review in Radiation Oncology [Editorials]: [image: 196.extract.jpg]
A case report: the first successful cochlear implant in Uganda.
*A case report: the first successful cochlear implant in Uganda.* Afr Health Sci. 2015 Dec;15(4):1342-8 Authors: Byaruhanga R, Roland JT, Buname G, Kakande E, Awubwa M, Ndorelire C, Namwagala J Abstract Hearing impairment is a significant disability. According to the World Health Organization (WHO), more than 80% of the world's approximately 120 million people with hearing impairment live in developing countries. Cochlear implant is the only therapeutic intervention for those with severe-profound sensorineural hearing loss. We are reporting an interesting case of the very first c... περισσότερα »
Pediatric Auditory Brainstem Implant Surgery: A New Option for Auditory Habilitation in Congenital Deafness?
*Pediatric Auditory Brainstem Implant Surgery: A New Option for Auditory Habilitation in Congenital Deafness?* J Am Board Fam Med. 2016 Mar-Apr;29(2):286-8 Authors: Shah PV, Kozin ED, Kaplan AB, Lee DJ Abstract INTRODUCTION: The auditory brainstem implant (ABI) is a neuroprosthetic device that provides sound sensations to individuals with profound hearing loss who are not candidates for a cochlear implant (CI) because of anatomic constraints. Herein we describe the ABI for family physicians. METHODS: PubMed was searched to identify articles relevant to the ABI, as well as articles...περισσότερα »
Endothelial dysfunction in patients with sudden sensorineural hearing loss.
Related Articles *Endothelial dysfunction in patients with sudden sensorineural hearing loss.* Adv Biomed Res. 2016;5:5 Authors: Berjis N, Moeinimehr M, Hashemi SM, Hashemi SM, Bakhtiari EK, Nasiri S Abstract BACKGROUND: Endothelial dysfunction probably has a role in the etiology of sudden sensorineural hearing loss (SSNHL). The aim of this study was determining of the relationship between endothelial dysfunction and SSNHL. MATERIALS AND METHODS: In a case-control study, 30 patients with SSNHL and 30 otherwise healthy age and sex-matched controls were studied. Demographic data g... περισσότερα »
Chemotherapy for Solid Tumors
ReCAP: Cost Differential of Chemotherapy for Solid Tumors [BUSINESS OF ONCOLOGY]: QUESTION ASKED: The objective of the present study is to determine the cost differentials between chemotherapeutic regimens (of similar or acceptable effectiveness) for common solid tumors in the metastatic and adjuvant settings. SUMMARY ANSWER: Of the 62 regimens included, the 6-month mean cost of chemotherapy was $26,989, and the median cost was $9,611. Mean cost of metastatic cancer therapy regimens was $35,315 compared with $18,107 for curative therapy. Regimens using biologics had higher mean cos... περισσότερα »
Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models
Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models: AbstractCpG oligodeoxynucleotides (CpG) potently activate the immune system by mimicking microbial DNA. Conjugation of CpG to chTNT-3, an antibody targeting the necrotic centers of tumors, enabled CpG to accumulate in tumors after systemic delivery, where it can activate the immune system in the presence of tumor antigens. CpG chemically conjugated to chTNT-3 (chTNT-3/CpG) were compared to free CpG in their ability to stimulate the immune system in vitro and reduce tumor burden in vivo... περισσότερα »
MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5
MicroRNAs let7 expression in thyroid cancer: correlation with their deputed targets HMGA2 and SLC5A5: Abstract PurposeThyroid cancer (TC), the most common endocrine malignancy, increases its incidence worldwide. MicroRNAs have been shown to be abnormally expressed in tumors and could represent valid diagnostic markers for patients affected by TC. Our aim was to analyze the expression of tumorsuppressor hsa-let7b-5p and hsa-let7f-5p, together with their predicted targets SLC5A5 (NIS) and HMGA2, in papillary (PTC), follicular (FTC) and anaplastic (ATC). Methods8 FTC, 14 PTC, 12 ...περισσότερα »
Novel SDHB and TMEM127 Mutations in Patients with Pheochromocytoma/Paraganglioma Syndrome
Novel SDHB and TMEM127 Mutations in Patients with Pheochromocytoma/Paraganglioma Syndrome: AbstractPheochromocytomas (Pheo) and paragangliomas (PGL) are rare tumors, with heterogeneous genetic background. In up to 30 % of all, apparently sporadic Pheo/PGL cases germline mutations can be identified in one of the 15 genes representing genetic susceptibility for Pheo/PGL. Malignancy is rare but it frequently associates with *SDHB* mutations. Our aim was to determine the prevalence of germline *SDHx*, *SDHAF2*, *MAX* and *TMEM127* mutations in Hungarian patients with apparently sporadi... περισσότερα »
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma
Targeted treatment and immunotherapy in leptomeningeal metastases from melanoma: Leptomeningeal metastases (LM) from melanoma has a historically poor prognosis with a median survival of about two months despite treatment. Targeted therapy and immune checkpoint inhibitors are promising new treatment options in advanced melanoma, that also can increase overall survival and may induce long lasting remission in patients with LM.
Targeting Hh pathway by MK-4101 in medulloblastoma and BCC
Targeting Hh pathway by MK-4101 in medulloblastoma and BCC: Aberrant activation of the Hedgehog (Hh) signaling pathway is implicated in the pathogenesis of many cancers, including medulloblastoma and basal cell carcinoma (BCC). In this study, using neonatally irradiated Ptch1+/- mice as a model of Hh-dependent tumors, we investigated the in vivo effects of MK-4101, a novel SMO antagonist, for treatment of medulloblastoma and BCC. Results clearly demonstrated a robust antitumor activity of MK-4101, achieved through the inhibition of proliferation and induction of extensive apoptosis...περισσότερα »
The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study
The Efficacy of Boric Acid Used to Treat Experimental Osteomyelitis Caused by Methicillin-Resistant Staphylococcus aureus : an In Vivo Study: AbstractWe explored the ability of local and systemic applications of boric acid (BA) to reduce the numbers of methicillin-resistant *Staphylococcus aureus* (MRSA) in a rat model of tibial osteomyelitis (OM), and compared boric acid with vancomycin (V). Implant-associated osteomyelitis was established in 35 rats. After 4 weeks, at which time OM was evident both radiologically and serologically in all animals, the rats were divided into five g...περισσότερα »
Nasal CD56 positive small round cell tumors
Virchows Arch. Nasal CD56 positive small round cell tumors. Differential diagnosis of hematological, neurogenic, and myogenic neoplasms. Liu Q1, Ohshima K, Sumie A, Suzushima H, Iwasaki H, Kikuchi M. Author information 1Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonanku, Fukuoka 814-01, Japan. Abstract CD56-positive nasal and nasal-type natural killer (NK)/T-cell lymphoma is now a well-defined disease entity. Rare cases of blastic NK-cell lymphoma positive for CD56 have been recently reported. However, CD56 expression is also identified in several...περισσότερα »
Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Related Articles *Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma.* BMC Cancer. 2016;16(1):192 Authors: Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J Abstract BACKGROUND: The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strat...περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Related Articles *Prognostic significance of GRP78/BiP expression in patients with Stage III/IV hypopharyngeal squamous cell carcinoma.* Neoplasma. 2016 Mar 8; Authors: Kaira K, Toyoda M, Shimizu A, Imai H, Sakukura K, Suzuki ON, Iijima M, Asao T, Chikamatsu K Abstract The immunoglobulin heavy chain binding protein (BiP)/glucose-regulated protein 78 (GRP78) plays an essential role in the endoplasmic reticulum (ER) stress, and GRP78/BiP is known to be highly expressed in various human neoplasms. The clinicopathological features of GRP78/BiP expression in patients with advanced hy...περισσότερα »
Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Related Articles *Relationships between p53 mutation, HPV status and outcome in oropharyngeal squamous cell carcinoma.* Radiother Oncol. 2016 Mar 4; Authors: Hong A, Zhang X, Jones D, Veillard AS, Zhang M, Martin A, Lyons JG, Lee CS, Rose B Abstract BACKGROUND AND PURPOSE: This study aimed to examine the rate and type of p53 mutation in oropharyngeal cancer (OSCC). Relationships were sought between human papillomavirus (HPV) status and p53 mutation. The role of p53 mutation as a prognostic factor independent of HPV status and as a modifier of the effect of HPV on outcomes was al... περισσότερα »
Sociodemographic disparities in choice of therapy and survival in advanced laryngeal cancer.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Related Articles *Sociodemographic disparities in choice of therapy and survival in advanced laryngeal cancer.* Am J Otolaryngol. 2016 Mar-Apr;37(2):65-9 Authors: Saini AT, Genden EM, Megwalu UC Abstract PURPOSE: To determine if sociodemographic factors are associated with treatment choice and survival in patients with advanced stage laryngeal cancer in the U.S. DESIGN/SETTING/SUBJECTS/METHODS: Population-based, non-concurrent cohort study of 5381 patients diagnosed with stage III or IV laryngeal squamous cell carcinoma from 1992-2009. Data was extracted from the Surveillance, E... περισσότερα »
Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
*Anti-EGFR therapy: Strategies in head and neck squamous cell carcinoma.* Recent Pat Anticancer Drug Discov. 2016 Mar 9; Authors: Oliveira-Silva J, de Carvalho AC, de Souza Viana L, Carvalho AL, Reis RM Abstract Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that activates downstream signaling pathways, including the Ras-MEK-Erk and PI3K-AKT pathways, leading to cell proliferation, resistance to apoptosis, angiogenesis and the ability to metastasize. EGFR overexpression is a significant finding in cancer, particularly in head and neck cancer, where it is al... περισσότερα »
Outcomes and Prognostic Factors of Radiation-Induced and De Novo Head and Neck Squamous Cell Carcinomas.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
*Outcomes and Prognostic Factors of Radiation-Induced and De Novo Head and Neck Squamous Cell Carcinomas.* Otolaryngol Head Neck Surg. 2016 Mar 8; Authors: Tay GC, Iyer NG, Ong WS, Tai D, Ang MK, Ha TC, Soo KC, Tan HK Abstract OBJECTIVE: We sought to compare clinical outcomes, pathological features, treatment patterns, and survival outcomes between radiation-induced squamous cell carcinoma (RISCC) and de novo SCC (DNSCC) of the head and neck, as well as identify prognostic factors in these patients. STUDY DESIGN: Case-control study. SETTING: Tertiary medical center. SUBJECTS AND ME... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
The importance of margins in head and neck cancer.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
*The importance of margins in head and neck cancer.* J Surg Oncol. 2016 Mar 9; Authors: Baddour HM, Magliocca KR, Chen AY Abstract An estimated 200,000 deaths each year worldwide are due to cancer of the head and neck, mostly mucosal squamous cell carcinoma and nonmelanoma skin cancer. The status of surgical margins is important for prognosis and need for adjuvant therapy. We will discuss how margin status impacts outcomes and therapy, and the conundrum of determining margin status. J. Surg. Oncol. © 2015 Wiley Periodicals, Inc. PMID: 26960076 [PubMed - as supplied by publisher] ... περισσότερα »
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.* Int J Clin Exp Pathol. 2015;8(3):2267-73 Authors: Saito T, Mitomi H, Yao T Abstract Basaloid squamous cell carcinoma (BSCC) is a rare and poorly differentiated variant of typical squamous cell carcinoma. Emerging studies show that genetic alterations are more frequent in BSCC than in conventional SCC, and some of which led to the identification of potential therapeutic targets in esophageal BSCC. Approximately half of the e... περισσότερα »
CD56-positive solid tumors : acute and chronic myeloid leukaemia, ovarian sex cord-stromal tumours, Wilms' tumor, neuroblastoma and ga nglioneuroblastoma, phaeochromocytoma/paraganglioma, astrocytoma, oligodendroglioma, ependymoma, meningioma, schwannoma, synovial sarcoma, mesenchymal chondrosarcoma, osteosarcoma, rhabdomyosarcoma, leiomyomatous tumours (except vascular types), and desmoplastic small cell tumour.
*Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors: * Summary*Background IMGN901 is a CD56-targeting antibody-drug conjugate designed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1 study investigated the safety, tolerability, pharmacokinetics, and preliminary activity of IMGN901 in patients with CD56-expressing solid tumors. Methods Patients were enrolled in cohorts of escalating IMGN901 doses, administered intravenously, on 3 consecutive days every 21 days. A dose-expansion phase accrued pat...περισσότερα »
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.
Pyogenic granuloma in patients treated with selective BRAF inhibitors: another manifestation of paradoxical pathway activation.: Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates. Common causes are mechanical trauma and cast immobilization, as well as multiple drugs such as retinoids and antineoplastic agents. However, the d... περισσότερα »
A comprehensive approach to the prevention of central venous catheter complications: results of 10-year prospective surveillance in pediatric hematology-oncology patients
A comprehensive approach to the prevention of central venous catheter complications: results of 10-year prospective surveillance in pediatric hematology-oncology patients: AbstractWe report our decennial experience with 1161 newly-placed long-term central venous catheters inserted in 919 hematology-oncology patients for a total of 413,901 CVC-days of observation. Most of the CVCs were partially-implanted, open-ended, Broviac-Hickman type of CVC (95 %). One thousand and twenty-four complications were recorded equal to 2.47 per 1000 CVC-days. The frequency of complications per CVC, t... περισσότερα »
Endothelial dysfunction in patients with sudden sensorineural hearing loss.
Endothelial dysfunction in patients with sudden sensorineural hearing loss.: Adv Biomed Res. 2016;5:5 Authors: Berjis N, Moeinimehr M, Hashemi SM, Hashemi SM, Bakhtiari EK, Nasiri S Abstract BACKGROUND: Endothelial dysfunction probably has a role in the etiology of sudden sensorineural hearing loss (SSNHL). The aim of this study was determining of the relationship between endothelial dysfunction and SSNHL. MATERIALS AND METHODS: In a case-control study, 30 patients with SSNHL and 30 otherwise healthy age and sex-matched controls were studied. Demographic data gathered included age... περισσότερα »
Pediatric Auditory Brainstem Implant Surgery: A New Option for Auditory Habilitation in Congenital Deafness?
Pediatric Auditory Brainstem Implant Surgery: A New Option for Auditory Habilitation in Congenital Deafness?: J Am Board Fam Med. 2016 Mar-Apr;29(2):286-8 Authors: Shah PV, Kozin ED, Kaplan AB, Lee DJ Abstract INTRODUCTION: The auditory brainstem implant (ABI) is a neuroprosthetic device that provides sound sensations to individuals with profound hearing loss who are not candidates for a cochlear implant (CI) because of anatomic constraints. Herein we describe the ABI for family physicians. METHODS: PubMed was searched to identify articles relevant to the ABI, as well as articles ...περισσότερα »
Cochlear implant
A case report: the first successful cochlear implant in Uganda.: Afr Health Sci. Authors: Byaruhanga R, Roland JT, Buname G, Kakande E, Awubwa M, Ndorelire C, Namwagala J Abstract Hearing impairment is a significant disability. According to the World Health Organization (WHO), more than 80% of the world's approximately 120 million people with hearing impairment live in developing countries. Cochlear implant is the only therapeutic intervention for those with severe-profound sensorineural hearing loss. We are reporting an interesting case of the very first cochlear implant operatio... περισσότερα »
Clinical Practice Recommendations For The Management And Prevention Of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.
Clinical Practice Recommendations For The Management And Prevention Of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.: Ther Drug Monit. 2016 Mar 5; Authors: Lee JW, Pussegoda K, Rassekh RS, Monzon JG, Liu G, Hwang S, Bhavsar AP, Pritchard S, Ross CJ, Amstutz U, Carleton BC, CPNDS clinical recommendations group Abstract Currently no pharmacogenomics-based criteria exist to guide clinicians in identifying individuals who are at risk of hearing loss from cisplatin-based chemotherapy. This review summarizes findings from pharmacogenomic studies that report genetic polym... περισσότερα »
Subtotal arytenoidectomy for the treatment of laryngeal stridor in multiple system atrophy: phonatory and swallowing results
Subtotal arytenoidectomy for the treatment of laryngeal stridor in multiple system atrophy: phonatory and swallowing results: ABSTRACT INTRODUCTION: There is a controversy concerning the terminology and definition of rhinitis in pregnancy. Gestational rhinitis is a relatively common condition, which has drawn increasing interest in recent years due to a possible association with maternal obstructive sleep apnea syndrome (OSAS) and unfavorable fetal outcomes. OBJECTIVE: To review the current knowledge on gestacional rhinitis, and to assess its evidence. METHODS: Structured literature... περισσότερα »
Giant sialolith of submandibular gland duct treated by excision and ductal repair: a case report
Giant sialolith of submandibular gland duct treated by excision and ductal repair: a case report: ABSTRACT INTRODUCTION: There is a controversy concerning the terminology and definition of rhinitis in pregnancy. Gestational rhinitis is a relatively common condition, which has drawn increasing interest in recent years due to a possible association with maternal obstructive sleep apnea syndrome (OSAS) and unfavorable fetal outcomes. OBJECTIVE: To review the current knowledge on gestacional rhinitis, and to assess its evidence. METHODS: Structured literature search. RESULTS: Gestationa... περισσότερα »
Rhinitis and pregnancy
Rhinitis and pregnancy: literature review: ABSTRACT INTRODUCTION: There is a controversy concerning the terminology and definition of rhinitis in pregnancy. Gestational rhinitis is a relatively common condition, which has drawn increasing interest in recent years due to a possible association with maternal obstructive sleep apnea syndrome (OSAS) and unfavorable fetal outcomes. OBJECTIVE: To review the current knowledge on gestacional rhinitis, and to assess its evidence. METHODS: Structured literature search. RESULTS: Gestational rhinitis and rhinitis "during pregnancy" are somewhat... περισσότερα »
Tinnitus and cell phones: the role of electromagnetic radiofrequency radiation
Tinnitus and cell phones: the role of electromagnetic radiofrequency radiation: ABSTRACT INTRODUCTION: Tinnitus is a multifactorial condition and its prevalence has increased on the past decades. The worldwide progressive increase of the use of cell phones has exposed the peripheral auditory pathways to a higher dose of electromagnetic radiofrequency radiation (EMRFR). Some tinnitus patients report that the abusive use of mobiles, especially when repeated in the same ear, might worsen ipsilateral tinnitus. OBJECTIVE: The aim of this study was to evaluate the available evidence about... περισσότερα »
Laryngoscopy evaluation protocol for the differentiation of essential and dystonic voice tremor
Laryngoscopy evaluation protocol for the differentiation of essential and dystonic voice tremor: ABSTRACT INTRODUCTION: Although syndromes that cause voice tremor have singular characteristics, the differential diagnosis of these diseases is a challenge because of the overlap of the existing signs and symptoms. OBJECTIVE: To develop a task-specific protocol to assess voice tremor by means of nasofibrolaryngoscopy and to identify those tasks that can distinguish between essential and dystonic tremor syndromes. METHODS: Cross-sectional study. The transnasal fiberoptic laryngoscopy pro...περισσότερα »
Suppurative labyrinthitis associated with otitis media
Suppurative labyrinthitis associated with otitis media: 26 years' experience: ABSTRACT INTRODUCTION: Suppurative labyrinthitis continues to result in significant hearing impairment, despite scientific efforts to improve not only its diagnosis but also its treatment. The definitive diagnosis depends on imaging of the inner ear, but it is usually clinically presumed. OBJECTIVE: To analyze the clinical factors and hearing outcomes in patients with labyrinthitis secondary to middle ear infections and to discuss findings based on imaging test results. METHODS: Retrospective cohort study,... περισσότερα »
Intensive care unit: results of the Newborn Hearing Screening
Intensive care unit: results of the Newborn Hearing Screening: ABSTRACT INTRODUCTION: Procedures for extending the life of newborns are closely related to potential causes of hearing loss, justifying the identification and understanding of risk factors for this deficiency. OBJECTIVE: To characterize the population, analyze the frequency of risk factors for hearing loss, and assess the audiological status of infants attended in a Newborn Hearing Screening program (NHS). METHODS: This was a retrospective study that analyzed medical records of 140 patients from a neonatal intensive car... περισσότερα »
Hearing performance and voice acoustics of cochlear implanted children
Hearing performance and voice acoustics of cochlear implanted children: ABSTRACT INTRODUCTION: The voice of hearing-impaired individuals has been described extensively, and exhibits abnormalities in quality, articulation and resonance. Having an understanding of the aspects that may have an impact on voice characteristics of cochlear implant users is important for users and for professionals in this field. OBJECTIVE: To verify the existence of correlation between age, time of device use, voice detection threshold, hearing category score and language category score with acoustic data...περισσότερα »
Cancer treatment in determination of hearing loss
Cancer treatment in determination of hearing loss: ABSTRACT INTRODUCTION: Chemotherapy and radiotherapy in oncology have repercussions in hearing health, and can damage structures of the inner ear. These repercussions usually, result in a bilateral and irreversible hearing loss. OBJECTIVE: To identify sensorineural hearing loss cases with complaints of tinnitus and difficulty in speech understanding and investigate their relationship with the types of chemotherapy and radiotherapy the patients received. METHODS: Cross-sectional, clinical, observational, analytical, historical cohort ...περισσότερα »
The influence of (central) auditory processing disorder in speech sound disorders
The influence of (central) auditory processing disorder in speech sound disorders: ABSTRACT INTRODUCTION: Considering the importance of auditory information for the acquisition and organization of phonological rules, the assessment of (central) auditory processing contributes to both the diagnosis and targeting of speech therapy in children with speech sound disorders. OBJECTIVE: To study phonological measures and (central) auditory processing of children with speech sound disorder. METHODS: Clinical and experimental study, with 21 subjects with speech sound disorder aged between 7....περισσότερα »
Objective assessment of surgical technique in rotation and nasal projection variation
Objective assessment of surgical technique in rotation and nasal projection variation: ABSTRACT INTRODUCTION: In rhinoplasty, facial esthetic analysis is critical for proper surgical planning. Parameters such as rotation and nasal projection should be routinely evaluated. Few studies have objectively assessed changes in facial angles postoperatively. OBJECTIVE: To evaluate the effectiveness of medial intercrural sutures and of rotation of the nasal tip on the increase of rotation and nasal projection in Caucasian patients undergoing primary rhinoplasty. METHODS: A prospective study ... περισσότερα »
Acoustic analysis of oropharyngeal swallowing using Sonar Doppler
Acoustic analysis of oropharyngeal swallowing using Sonar Doppler: ABSTRACT INTRODUCTION: During the aging process, one of the functions that changes is swallowing. These alterations in oropharyngeal swallowing may be diagnosed by methods that allow both the diagnosis and biofeedback monitoring by the patient. One of the methods recently described in the literature for the evaluation of swallowing is the Sonar Doppler. OBJECTIVE: To compare the acoustic parameters of oropharyngeal swallowing between different age groups. METHODS: This was a field, quantitative, study. Examination wi...περισσότερα »
Association between maxillary sinus pathologies and healthy teeth
Association between maxillary sinus pathologies and healthy teeth: ABSTRACT INTRODUCTION: The proximity of the roots to the maxillary sinus can create a variety of risks. OBJECTIVE: To evaluate the relationship between the roots of healthy teeth and the maxillary sinus, as well as the occurrence of sinus pathologies. METHODS: Three radiologists analyzed 109 cone beam computed tomography (CBCT) images. The Kappa test was used to assess the intra- and inter-rater agreement. The chi-squared test and prevalence ratio were used to test the hypothesis that roots of healthy teeth in the ma...περισσότερα »
Endoscopic sinus surgery dissection courses using a real simulator: the benefits of this training
Endoscopic sinus surgery dissection courses using a real simulator: the benefits of this training: ABSTRACT INTRODUCTION: Endonasal surgeries are among the most common procedures performed in otolaryngology. Due to difficulty in cadaver acquisition and the intrinsic risks of training residents during operations on real patients, nasosinusal endoscopic dissection courses utilizing real simulators, such as the Sinus Model Otorhino Neuro Trainer are being developed as a new technique to facilitate the acquisition of better anatomical knowledge and surgical skill. OBJECTIVE: To evaluate... περισσότερα »
Bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa
Experimental study on the effects of bismuth subgallate on the inflammatory process and angiogenesis of the oral mucosa: ABSTRACT INTRODUCTION: Bismuth subgallate is a salt derived from heavy metal. The aim of this study was to evaluate the effect of this salt on some phases of healing. OBJECTIVES: To assess the effect of subgallate on mucosa and to evaluate the association between the use of bismuth subgallate and neogenesis of vessels in oral mucosal wounds. METHODS: This was a prospective and experimental study. This study used sixty rats, which were divided into control and expe... περισσότερα »
The vestibular system poisoned by organophosphate
Morphological analysis of the vestibular system of guinea pigs poisoned by organophosphate: ABSTRACT INTRODUCTION: The vestibular system is responsible for body balance. There are substances that damage it, causing dizziness; these are termed vestibulotoxic substances. Agrochemicals have been investigated for ototoxicity because of studies that identified dizziness as a recurrent symptom among rural workers' complaints. OBJECTIVE: To histopathologically evaluate the vestibular system in guinea pigs exposed to an organophosphate, and to identify the drug's effects on this system. MET...περισσότερα »
The effects of concurrent cognitive tasks on postural sway in healthy subjects
The effects of concurrent cognitive tasks on postural sway in healthy subjects: ABSTRACT INTRODUCTION: Keeping balance of the upright stance is a highly practiced daily task for healthy adults and is effectively performed without overt attentional control in most. OBJECTIVE: The purpose of this study was to examine the influence of concurrent cognitive tasks on postural sway in healthy participants. METHODS: This was a prospective study. 20 healthy volunteer subjects were included. The cognitive and balance tasks were performed separately and then, concurrently. Postural control tas...περισσότερα »
Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis.
Salivary oxidant/ antioxidant status and hematological parameters in patients with recurrent aphthous stomatitis.: Caspian J Intern Med. 2016;7(1):13-8 Authors: Babaee N, Hosseinkazemi H, Pouramir M, Khakbaz Baboli O, Salehi M, Khadir F, Bijani A, Mehryari M Abstract BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative condition of oral cavity. The aim of this study was to compare the levels of the salivary Malondialdehyde (MDA) and total antioxidant capacity (TAC) and blood parameter in RAS versus healthy controls. METHODS: This case-control...περισσότερα »
Assessment of MRI image quality for various setup positions used in breast radiotherapy planning
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vikneswary Batumalai, Gary Liney, Geoff P. Delaney, Robba Rai, Miriam Boxer, Myo Min, Megan Berry, Trang Pham, Penny Phan, Callie Choong, Melanie Rennie, Christine Chan, Lois Holloway This study investigates breast magnetic resonance imaging (MRI) image quality for 3 different breast radiotherapy positions (prone, supine flat and supine inclined) and associated choice of breast coils. Supine breast MRI has comparable image quality to prone breast MRI for the purposes of radiotherapy delinea...περισσότερα »
Biological dosimetry to assess risks of health effects in victims of radiation accidents: Thirty years after Chernobyl
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vitali Moiseenko, Igor K. Khvostunov, Jona A. Hattangadi-Gluth, Ludvig P. Muren, David C. Lloyd from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1TNQ1fa via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YAUBfL via IFTTT
Histiocytosis with mixed cell populations
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1p9VQX3 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UUV6kT via IFTTT
Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies
Abstract Background Mycosis fungoides/Sézary syndrome (MF/SS) often requires multiple skin biopsies for definitive diagnosis. *In-vivo* reflectance confocal microscopy (RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/SS using RCM and to correlate RCM features with histopathology and T-cell receptor (TCR) gene rearrangement studies. Methods A cohort of patients with active/recurrent or suspicious MF/SS disease was prospectively recruited for RCM imaging and histopathologic/RCM images were evalu... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.
Related Articles *A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.* Cancer Biol Ther. 2016 Mar 8;:0 Authors: Diao Y, Liu J, Ma Y, Su M, Zhang H, Hao X Abstract Specific and efficient delivery of siRNA into intended tumor cells remains as a challenge, even though RNAi has been exploited as a new strategy for prostate cancer therapy. This work aims to address both specificity and efficiency of SURVIVIN-siRNA delivery by constructing a therapeutic complex using combinatorial strategies. A fusion protein ST...περισσότερα »
An uncommon cause of dysuria solved by “boom-boom” radiotherapy
Publication date: Available online 9 March 2016 *Source:*Cancer/Radiothérapie Author(s): R. Mazeron, J. Bosq, E. Rivin del Campo, J. Arfi-Rouche, A. Boros, D. Ghez BackgroundChronic lymphocytic leukaemia is a common disease affecting the hematopoietic organs. The disease remains classically indolent for years preceding a blast crisis. However, the disease can affect all parts of the body. We report here an unusual localization.Case presentationA 72-year-old man was followed for 2 years for an indolent chronic lymphocytic leukaemia while he presented a rapidly progressive dysuria. Pr... περισσότερα »
Anaesthesia and Sedation For Electrocochleography.
Related Articles *Anaesthesia and Sedation For Electrocochleography.* Acta Otolaryngol. 1974 Jan;77 Suppl 316:37-8 Authors: Zvonar M, Zvonar-Kuhndl B, Odenthal DW Abstract Anaesthesia and sedation in electrocochleo-graphy are of paramount importance for the whole procedure, since restlessness of the patient during the measurements can invalidate the results of the test. The time needed for extensive electrocochleography amounts on average to two hours. The only pain experienced during the procedure is associated with the placement of the transtympanic electrode. A relatively long...περισσότερα »
Methods for assessing high frequency hearing loss in every-day listening situations.
Related Articles *Methods for assessing high frequency hearing loss in every-day listening situations.* Acta Otolaryngol. 1974 Jan;77(320):1-50 Authors: Gunnar A PMID: 26947520 [PubMed] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1UUV2l8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UUV8JB via IFTTT
Scanning Electron Microscopy of the Inner Structure of the Organ of Corti and its Neural Pathways.
Related Articles *Scanning Electron Microscopy of the Inner Structure of the Organ of Corti and its Neural Pathways.* Acta Otolaryngol. 1974 Jan;77(319):57-66 Authors: Engström B Abstract Scanning electron microscopy has been used by the author since 1968 and has become an important tool in the study of inner ear structures. By the combination of good preparation and microdissection, light and electron microscopy, we can better visualize the structure of the normal and pathologically altered organ of Corti and also the vestibular sensory regions. In the present publication it is... περισσότερα »
The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.
Related Articles *The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.* Acta Otolaryngol. 1974 Jan;77(319):43-56 Authors: Angelborg C, Engström B Abstract The tympanic covering layer in guinea pig was studied with transmission and scanning electron microscopy. The tympanic border cells looked like bipolar ganglion cells with long processes. There was often a kinocilium on the cell body. The cells were rather similar structurally but their arrangement varied in the different coils. In the basal coil the cells were lying close together and oriented strictly lon... περισσότερα »
Distribution of Macromolecular Tracer Particles (Thorotrast(R)) in the Cochlea. An Electron Microscopic Study in Guinea Pig: Part I. The organ of Corti, the basilar membrane and the tympanic covering layer.
Related Articles *Distribution of Macromolecular Tracer Particles (Thorotrast(R)) in the Cochlea. An Electron Microscopic Study in Guinea Pig: Part I. The organ of Corti, the basilar membrane and the tympanic covering layer.* Acta Otolaryngol. 1974 Jan;77(319):19-41 Authors: Angelborg C Abstract Thorotrast(R) containing thorium dioxide particles with diameters of around 100 Å was introduced in perilymph or endolymph using various methods and concentrations. The location of the tracer particles in the cochleas was determined using the transmission electron microscope. Injection of... περισσότερα »
Surface Structures of the Human Vestibular Sensory Regions.
Related Articles *Surface Structures of the Human Vestibular Sensory Regions.* Acta Otolaryngol. 1974 Jan;77(319):3-18 Authors: Rosenhall U, Engström B Abstract The hair bundles and other surface organelles of the human vestibular sensory regions have been studied with SEM and TEM. The material was taken from individuals of different ages, from the fetal period to old age. The hair bundles have a remarkably mature appearance in fetuses three to four months old. Each hair bundle consists of one kinocilium and of many stereocilia of different length. Some hair bundles are shorter t... περισσότερα »
Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.
Related Articles *Predictors of Six-month Change in the Voice Handicap Index in a Treatment-seeking Population.* J Voice. 2016 Mar 4; Authors: Moore J, Greenberg C, Thibeault SL Abstract OBJECTIVE: To evaluate predictors of longitudinal change in patient-perceived voice impact as determined by the Voice Handicap Index (VHI). STUDY DESIGN: Prospective, survey study. METHODS: Patients consented to the University of Wisconsin Voice and Swallow Clinics Outcomes Database with voice, concerns with a baseline clinic visit from November 2012 to January 2014 were eligible for the study. ...περισσότερα »
Alcohol responsiveness in laryngeal dystonia: a survey study.
[image: http:--production.springer.de-OnlineReso] Related Articles *Alcohol responsiveness in laryngeal dystonia: a survey study.* J Neurol. 2015 Jun;262(6):1548-56 Authors: Kirke DN, Frucht SJ, Simonyan K Abstract Laryngeal dystonia (LD) is a task-specific focal dystonia of unknown pathophysiology affecting speech production. We examined the demographics of anecdotally reported alcohol use and its effects on LD symptoms using an online survey based on Research Electronic Data Capture (REDCap™) and National Spasmodic Dysphonia Association's patient registry. From 641 participants... περισσότερα »
Tinnitus: Is there a place for brain stimulation?
*Tinnitus: Is there a place for brain stimulation?* Surg Neurol Int. 2016;7(Suppl 4):S125-9 Authors: van Zwieten G, Smit JV, Jahanshahi A, Temel Y, Stokroos RJ Abstract Tinnitus is the perception of a "phantom sound" and has a high prevalence. Although many therapies have been investigated within the last decades, there is still no effective standard therapy. Animal studies and human functional imaging studies revealed that tinnitus perception is associated with many complex changes in multiple brain structures. There is growing evidence that brain stimulation might be able to int... περισσότερα »
Quantitative pupillometry and transcranial Doppler measurements in patients treated with hypothermia after cardiac arrest
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Associations between Gender and Cardiac Arrest Outcomes in Pan-Asian Out-of-Hospital Cardiac Arrest Patients
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An analysis of intravenous catheter placement among patients in a pediatric emergency department
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Assessment of 17 pediatric cases with colchicine poisoning in a 2-year period
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Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Jamie A. Dean, Liam C. Welsh, Dualta McQuaid, Kee H. Wong, Aleksandar Aleksic, Emma Dunne, Mohammad R. Islam, Anushka Patel, Priyanka Patel, Imran Petkar, Iain Phillips, Jackie Sham, Kate L. Newbold, Shreerang A. Bhide, Kevin J. Harrington, Sarah L. Gulliford, Christopher M. Nutting Background and purposeCurrent oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of t... περισσότερα »
Adjuvant radiation therapy in resected high-grade localized skeletal osteosarcomas treated with neoadjuvant chemotherapy: Long-term outcomes
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Claudio V. Sole, Felipe A. Calvo, Eduardo Alvarez, Mauricio Cambeiro, Miguel Cuervo, Mikel San Julian, Sebastian Sole, Rafael Martinez-Monge, Luis Sierrasesumaga PurposeTo assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas.Methods and materialsSeventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to Decemb... περισσότερα »
Assessment of MRI image quality for various setup positions used in breast radiotherapy planning
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vikneswary Batumalai, Gary Liney, Geoff P. Delaney, Robba Rai, Miriam Boxer, Myo Min, Megan Berry, Trang Pham, Penny Phan, Callie Choong, Melanie Rennie, Christine Chan, Lois Holloway This study investigates breast magnetic resonance imaging (MRI) image quality for 3 different breast radiotherapy positions (prone, supine flat and supine inclined) and associated choice of breast coils. Supine breast MRI has comparable image quality to prone breast MRI for the purposes of radiotherapy delineati...περισσότερα »
Biological dosimetry to assess risks of health effects in victims of radiation accidents: Thirty years after Chernobyl
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vitali Moiseenko, Igor K. Khvostunov, Jona A. Hattangadi-Gluth, Ludvig P. Muren, David C. Lloyd from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1TNQ1fa
The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.
Related Articles *The Tympanic Covering Layer. An Electron Microscopic Study in Guinea Pig.* Acta Otolaryngol. 1974 Jan;77(319):43-56 Authors: Angelborg C, Engström B Abstract The tympanic covering layer in guinea pig was studied with transmission and scanning electron microscopy. The tympanic border cells looked like bipolar ganglion cells with long processes. There was often a kinocilium on the cell body. The cells were rather similar structurally but their arrangement varied in the different coils. In the basal coil the cells were lying close together and oriented strictly lon... περισσότερα »
Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.
Related Articles *Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.* J Am Chem Soc. 2016 Mar 8; Authors: Nguyen MH, Imanishi M, Kurogi T, Smith AB Abstract Anion relay chemistry (ARC), an effective, multicomponent union tactic, was successfully employed for the total synthesis of the highly cytotoxic marine macrolide (-)-mandelalide A (1). The northern hemisphere was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemisphere was secured via a highly efficient ...περισσότερα »
Mindfulness, Mysticism, and Narrative Medicine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Mindfulness based interventions (MBIs) are rapidly emerging in health care settings for their role in reducing stress and improving physical and mental health. In such settings, the religious roots and affiliations of MBIs are downplayed, and the possibilities for developing spiritual, even mystical, states of consciousness are minimized. This article helps rebalance this trend […]
Shakespeare in the Operating Theater: A Review of Steven Soderberg’s The Knick , 2014
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
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Moderne Bildgebung von Nierentumoren – Anwendung in Diagnostik und Therapie
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Zusammenfassung Ziel des vorliegenden Artikels ist es, diagnostische Methoden zur Detektion und Charakterisierung von Nierentumoren darzulegen. Vorteile und Limitationen von Ultraschall, kontrastmittelverstärktem Ultraschall (CEUS), Computertomographie (CT) und Magnetresonanztomographie (MRT) werden präsentiert und diskutiert. Zusätzlich werden moderne Bildgebungsverfahren wie die Iodquantifizierung in der CT sowie die diffusionsgewichtete und die Perfusionsbildgebung in der MRT präsentiert. Zuletzt werden […]
Zur Lage der experimentellen Radiologie in Deutschland
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
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Mitteilungen des BDR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/24Swxtj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Optogenetic Inhibition of the Subthalamic Nucleus Reduces Levodopa-Induced Dyskinesias in a Rat Model of Parkinson’s Disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Background: The inhibition of neuronal activity by electrical deep brain stimulation is one of the mechanisms explaining the amelioration of levodopa-induced dyskinesia. However, electrical deep brain stimulation cannot specifically activate or inactivate selected types of neurons. Objectives: We applied optogenetics as an alternative treatment to deep brain stimulation for levodopa-induced dyskinesia, and also to confirm […]
RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first […]
Acute liver failure due to primary amyloidosis in a nephrotic syndrome: a swiftly progressive course
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
AL amyloidosis is a clonal plasma cell proliferative disorder characterised by extracellular tissue deposits of insoluble fibrils derived from or immunoglobulin light chains. The most common organs affected by AL amyloidosis are the kidney, presenting with nephrotic syndrome and/or progressive renal dysfunction, and the heart, with restrictive cardiomyopathy. Hepatic deposition of fibrils occurs in half […]
An uncommon cause of dysuria solved by “boom-boom” radiotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Publication date: Available online 9 March 2016 Source:Cancer/Radiothérapie Author(s): R. Mazeron, J. Bosq, E. Rivin del Campo, J. Arfi-Rouche, A. Boros, D. Ghez BackgroundChronic lymphocytic leukaemia is a common disease affecting the hematopoietic organs. The disease remains classically indolent for years preceding a blast crisis. However, the disease can affect all parts of the body. […]
Pericytes: A newly recognized player in wound healing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract Pericytes have generally been considered in the context of stabilizing vessels, ensuring the blood barriers, and regulating the flow through capillaries. However, new reports suggest that pericytes may function at critical times to either drive healing with minimal scarring or, perversely, contribute to fibrosis and ongoing scar formation. Beneficially, pericytes probably drive much of […]
Clinical evaluation of specific oral and salivary findings of coeliac disease in eastern Turkish paediatric patients.
Related Articles *Clinical evaluation of specific oral and salivary findings of coeliac disease in eastern Turkish paediatric patients.* Eur J Paediatr Dent. 2016 Mar;17(1):53-6 Authors: Dane A, Gürbüz T Abstract AIM: The aim of this study was to evaluate enamel defects (EDs), recurrent aphthous stomatitis (RAS) and salivary findings in Eastern Turkish children with coeliac disease (CD), and to compare the results with healthy children. MATERIALS AND METHODS: STUDY DESIGN: 70 children (35 CD patients and 35 healthy patients) aged between 5 to 15 years were included in this study. ... περισσότερα »
Inhibition of multispecies biofilms by a fluoride-releasing dental prosthesis copolymer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Inhibition of multispecies biofilms by a fluoride-releasing dental prosthesis copolymer.* J Dent. 2016 Mar 3; Authors: Yassin SA, German MJ, Rolland SL, Rickard AH, Jakubovics NS Abstract OBJECTIVES: This study aimed to develop a new mixed-species acidogenic biofilm model and use it to assess the antimicrobial properties of a novel fluoride-releasing copolymer. METHODS: Stubs composed of a copolymer of methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA) with polymethyl methacrylate (PMMA) were produc... περισσότερα »
Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.* Crit Rev Oncol Hematol. 2016 Feb 1; Authors: De Sanctis V, Bossi P, Sanguineti G, Trippa F, Ferrari D, Bacigalupo A, Ripamonti CI, Buglione M, Pergolizzi S, Langendjik JA, Murphy B, Raber-Durlacher J, Russi EG, Lalla RV Abstract BACKGROUND: Oral mucositis (OM) due to radiotherapy and systemic therapies in head and neck cancer treatment represents a major problem causing a wide ... περισσότερα »
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.* Cell Rep. 2016 Mar 2; Authors: Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT, He W, Miller MS, Lin X Abstract Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively. Here, we have found that CARMA3, a scaffold protein previously shown to medi... περισσότερα »
Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: A retrospective case series.
Related Articles *Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: A retrospective case series.* Med Oral Patol Oral Cir Bucal. 2016 Mar 6;:0 Authors: Gay-Escoda C, Pérez-Álvarez D, Camps-Font O, Figueiredo R Abstract BACKGROUND: The existing information on oral rehabilitations with dental implants in VIH-positive patients is scarce and of poor quality. Moreover, no long-term follow-up studies are available. Hence, the aims of this study were to describe the long-term survival and success rates of dental implants in a group of HIV-positive ... περισσότερα »
Soft Tissue Necrosis in Head and Neck Cancer Patients After Transoral Robotic Surgery or Wide Excision With Primary Closure Followed by Radiation Therapy.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Soft Tissue Necrosis in Head and Neck Cancer Patients After Transoral Robotic Surgery or Wide Excision With Primary Closure Followed by Radiation Therapy.* Medicine (Baltimore). 2016 Mar;95(9):e2852 Authors: Yun Hee L, Kim YS, Chung MJ, Yu M, Jung SL, Yoo IeR, Lee YS, Kim MS, Sun DI, Kang JH Abstract Risk factors were evaluated for surgical bed soft tissue necrosis (STN) in head and neck cancer patients treated with postoperative radiation therapy (PORT) after transoral robotic surgery (TORS) or wide excision wit... περισσότερα »
Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.* J Dermatolog Treat. 2016 Mar 4;:1-3 Authors: Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G Abstract OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most commonly seen inflammatory disease in the oral mucosa affecting 5%-25% of the general population. The etiology of RAS is still not fully understood and its treatment is very challenging. With its anti-inflammatory affects, colchicine is used for system... περισσότερα »
Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models.
[image: http:--http://ift.tt/1M8vfzn] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models.* Front Oncol. 2016;6:30 Authors: Walenta S, Mueller-Klieser W Abstract This review is focused on the radiobiology of carbon ions compared to X-rays using multicellular models of tumors and normal mucosa. The first part summarizes basic radiobiological effects, as observed in cancer cells. The second, mor... περισσότερα »
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Related Articles *UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.* Blood. 2016 Mar 3; Authors: Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, Krystal G Abstract Herein we demonstrate that oncolytic herpes simplex virus -1 (HSV-1) potently activates human peripheral blood mononuclear cells (PBMC) to lyse leukemic cell lines and primary acute myeloid leukemia samples, but not healthy allogeneic lymphocytes. Intriguingly, we found that ultraviolet light (UV)-inactivated H...περισσότερα »
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.
[image: http:--production.springer.de-OnlineReso] Related Articles *Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.* Arch Virol. 2016 Mar 3; Authors: Suda Y, Fukushi S, Tani H, Murakami S, Saijo M, Horimoto T, Shimojima M Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. The experimental use of CCHF virus (CCHFV), which causes CCHF, requires high-biosafety-level (BSL) containment. In contrast, ... περισσότερα »
Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.* J Ethnopharmacol. 2016 Feb 28; Authors: Shi CJ, Wen XS, Gao HF, Liu ZH, Xu XK, Li LF, Shen T, Xian CJ Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions. In traditional Chinese medicine, chemotherapeutic toxicity is diagnosed as Qi and Yin deficiency, and steamed reh... περισσότερα »
Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study.* Mycoses. 2016 Mar 2; Authors: Preissner S, Kastner I, Schütte E, Hartwig S, Schmidt-Westhausen AM, Paris S, Preissner R, Hertel M Abstract Extended use of antimycotics in oral candidiasis therapy gives rise to problems related to fungal drug resistance. The aim of this pilot study was to investigate the efficacy of tissue tolerable plas... περισσότερα »
Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience.* Laryngoscope. 2016 Mar 1; Authors: Hazkani I, Rabinovics N, Limon D, Silvern D, Koren S, Hadar T, Bachar G, Shpitzer T, Popovtzer A Abstract OBJECTIVES/HYPOTHESIS: Despite advances in radiotherapy and chemotherapy treatments for head and neck cancers, the local failure rate is high. In most radiotherapy-resistant cases, surgery is performed; however, some cases are considered unresectable. No standard treatment... περισσότερα »
Structured review of papers reporting specific functions in patients with cancer of the head and neck: 2006 - 2013.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Structured review of papers reporting specific functions in patients with cancer of the head and neck: 2006 - 2013.* Br J Oral Maxillofac Surg. 2016 Feb 25; Authors: Rogers SN, Heseltine N, Flexen J, Winstanley HR, Cole-Hawkins H, Kanatas A Abstract Health-related quality of life (HRQoL) focuses on 4 core domains: physical and psychological function, social interaction, disease, and treatment-related symptoms, and is a key outcome in patients with cancer of the head and neck. We reviewed papers published between ... περισσότερα »
Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.
[image: http:--production.springer.de-OnlineReso] Related Articles *Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.* J Cancer Res Clin Oncol. 2016 Feb 26; Authors: Rabitsch W, Bojic M, Wohlfarth P, Leiner M, Schörgenhofer C, Kalhs P, Schulenburg A, Sillaber C, Mitterbauer M, Sperr WR, Jäger U, Skrabs K, Greinix H, Hermann A, Lamm W Abstract PURPOSE: Treatment of refractory Hodgkin disease deserves specific considerations. Recently, alemtuzumab-BEAM has been introduced in al... περισσότερα »
Optogenetic Inhibition of the Subthalamic Nucleus Reduces Levodopa-Induced Dyskinesias in a Rat Model of Parkinson’s Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: The inhibition of neuronal activity by electrical deep brain stimulation is one of the mechanisms explaining the amelioration of levodopa-induced dyskinesia. However, electrical deep brain stimulation cannot specifically activate or inactivate selected types of neurons. Objectives: We applied optogenetics as an alternative treatment to deep brain stimulation for levodopa-induced dyskinesia, and also to confirm […]
The importance of margins in head and neck cancer.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The importance of margins in head and neck cancer. J Surg Oncol. 2016 Mar 9; Authors: Baddour HM, Magliocca KR, Chen AY Abstract An estimated 200,000 deaths each year worldwide are due to cancer of the head and neck, mostly mucosal squamous cell carcinoma and nonmelanoma skin cancer. The status of surgical margins is important […]
Timely Antecedent CT or MRI Can Help Predict Hemorrhage Site of Posttreatment Head and Neck Cancer, With Digital Subtraction Angiography Used as the Reference Standard.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Timely Antecedent CT or MRI Can Help Predict Hemorrhage Site of Posttreatment Head and Neck Cancer, With Digital Subtraction Angiography Used as the Reference Standard. AJR Am J Roentgenol. 2016 Mar 9;:829-836 Authors: Ku YK, Wong YC, Fu CJ, Tseng HJ, Wang LJ, Wang CJ, Chin SC Abstract OBJECTIVE: We investigated the timing of CT […]
Management of arterial injury during endoscopic sinus and skull base surgery.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Management of arterial injury during endoscopic sinus and skull base surgery. Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):170-174 Authors: Valentine R, Padhye V, Wormald PJ Abstract PURPOSE OF REVIEW: The most feared complication during endonasal surgery is a carotid artery injury. The sheep model of carotid injury provides training for this event by giving […]
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
How to minimize morbidity in radiotherapy of pharyngolaryngeal tumors? Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):163-169 Authors: Henriques de Figueiredo B, Grégoire V Abstract PURPOSE OF REVIEW: Radiotherapy is one of the most effective treatment modalities for head and neck cancer. However, because of the intricacy between tumors and normal tissues, it can induce […]
Facial nerve identification with fluorescent dye in rats.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Facial nerve identification with fluorescent dye in rats. Acta Cir Bras. 2016 Feb;31(2):92-102 Authors: Melo GM, Cervantes O, Covolan L, Baptista HA, Ferreira ES, Abrahao M Abstract PURPOSE The parotidectomy technique still has an elevated paresis and paralysis index, lowering patient life’s quality. The correct identification of the facial nerve can prevent nerve damage. Fluorescent […]
Variability in the Cross-Sectional Area and Narrowing of the Internal Jugular Vein in Patients Without Multiple Sclerosis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Variability in the Cross-Sectional Area and Narrowing of the Internal Jugular Vein in Patients Without Multiple Sclerosis. AJR Am J Roentgenol. 2016 Mar 9;:1-5 Authors: Buch K, Groller R, Nadgir RN, Fujita A, Qureshi MM, Sakai O Abstract OBJECTIVE: Chronic cerebrospinal vascular insufficiency is a proposed condition of intraluminal stenosis of the internal jugular vein […]
Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid cystic carcinoma. Oncotarget. 2016 Mar 6; Authors: Liu S, Ye D, Xu D, Liao Y, Zhang L, Liu L, Yu W, Wang Y, He Y, Hu J, Guo W, Wang T, Sun B, Song H, Yin H, Liu J, Wu Y, Zhu […]
Tinnitus: Is there a place for brain stimulation?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tinnitus: Is there a place for brain stimulation? Surg Neurol Int. 2016;7(Suppl 4):S125-9 Authors: van Zwieten G, Smit JV, Jahanshahi A, Temel Y, Stokroos RJ Abstract Tinnitus is the perception of a «phantom sound» and has a high prevalence. Although many therapies have been investigated within the last decades, there is still no effective standard […]
Plunging Ranulas Revisited: A CT Study with Emphasis on a Defect of the Mylohyoid Muscle as the Primary Route of Lesion Propagation.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Plunging Ranulas Revisited: A CT Study with Emphasis on a Defect of the Mylohyoid Muscle as the Primary Route of Lesion Propagation. Korean J Radiol. 2016 Mar-Apr;17(2):264-70 Authors: Lee JY, Lee HY, Kim HJ, Jeong HS, Kim YK, Cha J, Kim ST Abstract OBJECTIVE: The purpose of this study was to clarify the pathogenesis of […]
Disability evaluation in acoustic blast trauma.
*Disability evaluation in acoustic blast trauma.* Indian J Occup Environ Med. 2015 Sep-Dec;19(3):138-40 Authors: Raju G Abstract INTRODUCTION: Acoustic blast trauma is different from Noise induced hearing loss. Blast trauma can damage the tympanic membrane, ossicles and cochlea singly or in combination. It produces immediate severe hearing loss and may be associated with tinnitus and vestibular symptoms. Hearing loss recovers spontaneously in many cases but may be permanent in 30-55% cases. Thirteen patients working in an explosive manufacturing unit in Andhra Pradesh were expose...περισσότερα »
Emerging hubs in phantom perception connectomics.
Related Articles *Emerging hubs in phantom perception connectomics.* Neuroimage Clin. 2016;11:181-94 Authors: Mohan A, De Ridder D, Vanneste S Abstract Brain networks are small-world networks typically characterized by the presence of hubs, i.e. nodes that have significantly greater number of links in comparison to other nodes in the network. These hubs act as short cuts in the network and promote long-distance connectivity. Long-distance connections increase the efficiency of information transfer but also increase the cost of the network. Brain disorders are associated with an ... περισσότερα »
Efficacy of balloon dilation in the treatment of symptomatic Eustachian tube dysfunction: One year follow-up study.
Related Articles *Efficacy of balloon dilation in the treatment of symptomatic Eustachian tube dysfunction: One year follow-up study.* Am J Otolaryngol. 2016 Mar-Apr;37(2):99-102 Authors: Xiong H, Liang M, Zhang Z, Xu Y, Ou Y, Chen S, Yang H, Zheng Y Abstract PURPOSE: Eustachian tube balloon dilation (ETBD) has been recently described as feasible treatment for patients with refractory Eustachian tube dysfunction (ETD). The aim of this study was to evaluate the efficacy of ETBD in the treatment of symptomatic Eustachian tube dysfunction (SETD) by subjective and objective analysis.... περισσότερα »
SENP1 but not fetal hemoglobin differentiates chronic mountain sickness from healthy Andean highlanders.
Related Articles *SENP1 but not fetal hemoglobin differentiates chronic mountain sickness from healthy Andean highlanders.* Exp Hematol. 2016 Mar 4; Authors: Hsieh MM, Callacondo D, Rojas-Camayo J, Quesada-Olarte J, Wang X, Uchida N, Maric I, Remaley AT, Leon-Velarde F, Villafuerte FC, Tisdale JF Abstract Chronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized modest increases in fetal hemoglobin (HbF) is associated with lower CMS severity. In this cross-sectional study, we showed that normal HbF levels (med... περισσότερα »
DNA Damage in CD133-Positive Cells in Barrett’s Esophagus and Esophageal Adenocarcinoma
Barrett's esophagus (BE) caused by gastroesophageal reflux is a major risk factor of Barrett's esophageal adenocarcinoma (BEA), an inflammation-related cancer. Chronic inflammation and following tissue damage may activate progenitor cells under reactive oxygen/nitrogen species-rich environment. We previously reported the formation of oxidative/nitrative stress-mediated mutagenic DNA lesions, 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-nitroguanine, in columnar epithelial cells of BE tissues and cancer cells of BEA tissues. We investigated the mechanisms of BEA development ... περισσότερα »
Tuberculosis of the Breast: An Initial Presentation of the Metabolic Syndrome with Type 2 Diabetes Mellitus in a Young Nigerian Woman
Breast tuberculosis is an uncommon presentation of extra pulmonary tuberculosis. A 40-year-old obese woman presented with a right breast abscess which had failed to heal after surgical drainage. There was no family history of breast disease. Biopsy and histology of the lesion showed chronic granulomatous inflammation with positive stains for acid fast bacilli compatible with tuberculosis. Further evaluation confirmed metabolic syndrome with type 2 diabetes mellitus. She was placed on antituberculosis chemotherapy and appropriate therapy for diabetes mellitus with complete resoluti...περισσότερα »
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RBkgQ5 via IFTTT
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LTarQT via IFTTT
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LTaDzB via IFTTT
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XeyhqU via IFTTT
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LTaDjk via IFTTT
The Genetic Evolution of Melanoma
New England Journal of Medicine, Volume 374, Issue 10, Page 993-996, March 2016. from melanoma2 via als.fakia on Inoreader http://ift.tt/1UUIc6q via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QJbDGT via IFTTT
Repeat Ultrasound-Guided Fine-Needle Aspiration for Thyroid Nodules 10 mm or Larger Can Be Performed 10.7 Months After Initial Nondiagnostic Results
American Journal of Roentgenology, Ahead of Print. from thyroid via a.lsfakia on Inoreader http://ift.tt/1QO9GWg via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SBRcgf via IFTTT
Identification of crucial regulatory relationships between long non-coding RNAs and protein-coding genes in lung squamous cell carcinoma
Conclusion A set of regulatory relationships between PVT1 and its targets and regulators, as well as TERC and its targets and regulators, may play crucial roles in the progress of LUSC. (Source: Molecular and Cellular Probes) from squamous cell carcinoma via ok on Inoreader http://ift.tt/221ZV1m via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/225auxd via IFTTT
Identification of crucial regulatory relationships between long non-coding RNAs and protein-coding genes in lung squamous cell carcinoma
Conclusion A set of regulatory relationships between PVT1 and its targets and regulators, as well as TERC and its targets and regulators, may play crucial roles in the progress of LUSC. (Source: Molecular and Cellular Probes) from squamous cell carcinoma via ok on Inoreader http://ift.tt/1QFMgVf via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SBRbZH via IFTTT
The Self-Reported Use of Immunostains and Cytogenetic Testing in the Diagnosis of Melanoma by Practicing U.S. Pathologists of 10 Selected States
Abstract Background The diagnosis of melanoma can be challenging, especially in lesions for which the histopathologic criteria bridge two or more taxonomic categories. Newer genomic analytical methods of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) have been introduced as ancillary techniques to differentiate benign and malignant melanocytic proliferations. Methods We evaluated how pathologists perceive and are incorporating these new cytogenetic testing technologies into their practices. We conducted a study of 207 U.S. pathologists who ... περισσότερα »
Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies.
[image: wk-health-logo.gif] Objectives: To determine the association of hyponatremia at presentation with clinical and imaging outcomes in patients with acute intracerebral hemorrhage. Design: Retrospective pooled analysis of prospectively collected data from 3,243 participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 (international, multicenter, open, blinded endpoint, randomized controlled trials designed to assess the effects of early intensive blood pressure lowering in patients with acute intracerebral ... περισσότερα »
Anti-centriole antibody: An infectious or autoimmune process?
*Biman Saikia, Yashwant Kumar, Ranjana W Minz, Seema Chhabra* Indian Journal of Allergy, Asthma and Immunology 2015 29(2):84-87 Anti-centriolar pattern of staining by indirect immunofluorescence (IIF) on human epithelial type 2 (Hep2) cells is rarely observed, mostly in association with scleroderma and scleroderma-like connective tissue disorders. This paper describes four patients with anti-centriole antibody positivity along with a review of the available literature. In this retrospective study, a total of four cases whose serum showed the centriolar pattern on Hep2 cell lines d... περισσότερα »
Hereditary angioedema: A case report and literature review
*Srikant Behera, Lubna Zafar, Asif Hasan* Indian Journal of Allergy, Asthma and Immunology 2015 29(2):92-95 Hereditary angioedema (HAE), also known as Quincke's disease, is an autosomal dominant condition characterized by painless and nonpitting swelling of soft tissues. It is not an allergic phenomenon, as it appears to be on initial examination, thus fails to respond to injectable steroids and adrenaline. The disease may become potentially life threatening due to involvement of airway, thus early suspicion, recognition, and treatment of disease are important. We present here a c... περισσότερα »
The comparison of sensitization to animal allergens in children and adult-onset patients with asthma
*Mozhgan Moghtaderi, Shirin Farjadian, Zeinab Hosseini, Dorna Eghtedari* Indian Journal of Allergy, Asthma and Immunology 2015 29(2):67-71 Background: With higher exposure to animal during the life, the risk of sensitization to animals may get more. The purpose of this study was the comparison of sensitization to animal allergens in children with asthma from those with adult-onset asthma. Materials and Methods: This cross-sectional study included 100 children and 100 adults with asthma as well as 100 healthy individuals with no history of asthma and atopy. Skin tests were performe...περισσότερα »
Assessment of MRI image quality for various setup positions used in breast radiotherapy planning
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vikneswary Batumalai, Gary Liney, Geoff P. Delaney, Robba Rai, Miriam Boxer, Myo Min, Megan Berry, Trang Pham, Penny Phan, Callie Choong, Melanie Rennie, Christine Chan, Lois Holloway This study investigates breast magnetic resonance imaging (MRI) image quality for 3 different breast radiotherapy positions (prone, supine flat and supine inclined) and associated choice of breast coils. Supine breast MRI has comparable image quality to prone breast MRI for the purposes of radiotherapy delinea...περισσότερα »
Biological dosimetry to assess risks of health effects in victims of radiation accidents: Thirty years after Chernobyl
Publication date: Available online 9 March 2016 *Source:*Radiotherapy and Oncology Author(s): Vitali Moiseenko, Igor K. Khvostunov, Jona A. Hattangadi-Gluth, Ludvig P. Muren, David C. Lloyd from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1TNQ1fa via IFTTT
Histiocytosis with mixed cell populations
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Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies
Abstract Background Mycosis fungoides/Sézary syndrome (MF/SS) often requires multiple skin biopsies for definitive diagnosis. *In-vivo* reflectance confocal microscopy (RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/SS using RCM and to correlate RCM features with histopathology and T-cell receptor (TCR) gene rearrangement studies. Methods A cohort of patients with active/recurrent or suspicious MF/SS disease was prospectively recruited for RCM imaging and histopathologic/RCM images were evalu... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.
Related Articles *A specific aptamer-cell penetrating peptides complex delivered siRNA efficiently and suppressed prostate tumor growth in vivo.* Cancer Biol Ther. 2016 Mar 8;:0 Authors: Diao Y, Liu J, Ma Y, Su M, Zhang H, Hao X Abstract Specific and efficient delivery of siRNA into intended tumor cells remains as a challenge, even though RNAi has been exploited as a new strategy for prostate cancer therapy. This work aims to address both specificity and efficiency of SURVIVIN-siRNA delivery by constructing a therapeutic complex using combinatorial strategies. A fusion protein ST...περισσότερα »
An uncommon cause of dysuria solved by “boom-boom” radiotherapy
Publication date: Available online 9 March 2016 *Source:*Cancer/Radiothérapie Author(s): R. Mazeron, J. Bosq, E. Rivin del Campo, J. Arfi-Rouche, A. Boros, D. Ghez BackgroundChronic lymphocytic leukaemia is a common disease affecting the hematopoietic organs. The disease remains classically indolent for years preceding a blast crisis. However, the disease can affect all parts of the body. We report here an unusual localization.Case presentationA 72-year-old man was followed for 2 years for an indolent chronic lymphocytic leukaemia while he presented a rapidly progressive dysuria. Pr... περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Is a Wider Margin (2 cm vs. 1 cm) for a 1.01-2.0 mm Melanoma Necessary?
*Is a Wider Margin (2 cm vs. 1 cm) for a 1.01-2.0 mm Melanoma Necessary?* Ann Surg Oncol. 2016 Mar 8; Authors: Doepker MP, Thompson ZJ, Fisher KJ, Yamamoto M, Nethers KW, Harb JN, Applebaum MA, Gonzalez RJ, Sarnaik AA, Messina JL, Sondak VK, Zager JS Abstract BACKGROUND: The current NCCN recommendation for resection margins in patients with melanomas between 1.01 and 2 mm deep is a 1-2 cm radial margin. We sought to determine whether margin width had an impact on local recurrence (LR), disease-specific survival (DSS), and type of wound closure. METHODS: Melanomas measuring 1.01-2.0... περισσότερα »
PRIMARY MALIGNANT AMELANOTIC MELANOMA ARISING FROM A VITILIGO PATCH OF AN AFRICAN TANZANIAN: CASE REPORT.
Related Articles *PRIMARY MALIGNANT AMELANOTIC MELANOMA ARISING FROM A VITILIGO PATCH OF AN AFRICAN TANZANIAN: CASE REPORT.* East Afr Med J. 2014 May;91(5):178-80 Authors: Kiprono SK, Mavura DR, Masenga EJ, Möhrle M, Metzler G Abstract Skin cancer is rare in people of African origin while vitiligo occurs worldwide. The occurrence of primary malignant melanoma and vitiligo together is very rare. We present a rare case of primary malignant amelanotic melanoma arising from a depigmented patch of a patient with vitiligo. It was completely excised and followed for one year. No recurr... περισσότερα »
A clinicopathological analysis of primary mucosal malignant melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *A clinicopathological analysis of primary mucosal malignant melanoma.* Surg Today. 2015 Jul;45(7):886-91 Authors: Izumi D, Ishimoto T, Yoshida N, Nakamura K, Kosumi K, Tokunaga R, Sugihara H, Sawayama H, Karashima R, Imamura Y, Ida S, Hiyoshi Y, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Watanabe M, Baba H Abstract PURPOSES: Primary mucosal malignant melanoma (PMMM) is a rare and highly lethal neoplasm associated with a poor prognosis. CXC chemokine receptor 4 (CXCR4) is expressed on various tumor cells, including...περισσότερα »
Germline RAD51B truncating mutation in a family with cutaneous melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *Germline RAD51B truncating mutation in a family with cutaneous melanoma.* Fam Cancer. 2015 Jun;14(2):337-40 Authors: Wadt KA, Aoude LG, Golmard L, Hansen TV, Sastre-Garau X, Hayward NK, Gerdes AM Abstract Known melanoma predisposition genes only account for around 40% of high-density melanoma families. Other rare mutations are likely to play a role in melanoma predisposition. RAD51B plays an important role in DNA repair through homologous recombination, and inactivation of RAD51B has been implicated in tumorigene... περισσότερα »
BRAFV600 mutant non-small-cell lung cancer resistant to Vemurafenib.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *BRAFV600 mutant non-small-cell lung cancer resistant to Vemurafenib.* Int J Clin Exp Pathol. 2015;8(3):3294-8 Authors: El Karak F, Assi T, Kourie HR, El Rassy E, Chebib R, Ghor M, Tabchi S Abstract Vemurafenib has shown significant activity in V600 mutant melanoma; however the role of this agent in Lung adenocarcinoma with an activating BRAF mutation is still evolving. One of our patients had a rare activating BRAF mutation detected through tumor exome sequencing, which led to a switch from her successful therapy to Vemurafe... περισσότερα »
Germline RAD51B truncating mutation in a family with cutaneous melanoma.
[image: http:--production.springer.de-OnlineReso] Related Articles *Germline RAD51B truncating mutation in a family with cutaneous melanoma.* Fam Cancer. 2015 Jun;14(2):337-40 Authors: Wadt KA, Aoude LG, Golmard L, Hansen TV, Sastre-Garau X, Hayward NK, Gerdes AM Abstract Known melanoma predisposition genes only account for around 40% of high-density melanoma families. Other rare mutations are likely to play a role in melanoma predisposition. RAD51B plays an important role in DNA repair through homologous recombination, and inactivation of RAD51B has been implicated in tumorigene... περισσότερα »
BRAFV600 mutant non-small-cell lung cancer resistant to Vemurafenib.
[image: http:--http://ift.tt/1Fkw4zC] Related Articles *BRAFV600 mutant non-small-cell lung cancer resistant to Vemurafenib.* Int J Clin Exp Pathol. 2015;8(3):3294-8 Authors: El Karak F, Assi T, Kourie HR, El Rassy E, Chebib R, Ghor M, Tabchi S Abstract Vemurafenib has shown significant activity in V600 mutant melanoma; however the role of this agent in Lung adenocarcinoma with an activating BRAF mutation is still evolving. One of our patients had a rare activating BRAF mutation detected through tumor exome sequencing, which led to a switch from her successful therapy to Vemurafe... περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature.* J Cutan Pathol. 2016 Mar 9; Authors: Nguyen CM, Chong K, Cassarino D Abstract Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear c... περισσότερα »
Primary thyroid lymphoma: a rare thyroid malignancy.
Related Articles *Primary thyroid lymphoma: a rare thyroid malignancy.* J Coll Physicians Surg Pak. 2011 Dec;21(12):775-7 Authors: Mukhtar R, Khattak R, Mateen A Abstract Incidence of thyroidal masses is very high with predominance in females. Most of these masses are benign. Malignancy can be of thyroid or non-thyroid origin. Surgery is treatment of choice in the former but not in latter. Primary thyroid lymphoma (PTL) is a rare cause of thyroid malignancy of non-thyroid origin which is highly treatable without surgery but early diagnosis is important requisite to have better ou... περισσότερα »
Italian cancer figures - Report 2015: The burden of rare cancers in Italy.
Related Articles *Italian cancer figures - Report 2015: The burden of rare cancers in Italy.* Epidemiol Prev. 2016 Jan-Feb;40(1 Suppl 2):1-120 Authors: Busco S, Buzzoni C, Mallone S, Trama A, Castaing M, Bella F, Amodio R, Bizzoco S, Cassetti T, Cirilli C, Cusimano R, De Angelis R, Fusco M, Gatta G, Gennaro V, Giacomin A, Giorgi Rossi P, Mangone L, Mannino S, Rossi S, Pierannunzio D, Tavilla A, Tognazzo S, Tumino R, Vicentini M, Vitale MF, Crocetti E, DalMaso L, AIRTUM Working Group Abstract OBJECTIVES This collaborative study, based on data collected by the network of Italian Ca... περισσότερα »
Repeat Ultrasound-Guided Fine-Needle Aspiration for Thyroid Nodules 10 mm or Larger Can Be Performed 10.7 Months After Initial Nondiagnostic Results
American Journal of Roentgenology, Ahead of Print. from thyroid via a.lsfakia on Inoreader http://ift.tt/1QO9GWg via IFTTT
Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.
Related Articles Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests. J Gen Virol. 2016 Feb 23; Authors: Iheozor-Ejiofor RP, Levanov L, Hepojoki J, Strandin T, Lundkvist Å, Plyusnin A, Vapalahti O Abstract Puumala virus (PUUV) grows slowly in cell culture. To study antigenic… Continue reading Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.
Researchers find highly active gene in aggressive human lung cancer
Scientists believe that «conserved» genes — those found in life forms that range from bacteria to plants, insects and humans — perform vital biological functions across species. And limited research on one of those genes, Nitrilase 1 (Nit1), suggested… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1nyTeRg via IFTTT
Immunology meets single-cell sequencing
Research from the Single-Cell Genomics Centre on the Wellcome Genome Campus could change the way we look at gene expression and immune response. Published in Nature Methods, the new method, TraCeR, provides a powerful tool for research into immune… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1R8YTvc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete… Continue reading Immunology meets single-cell sequencing
RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets
RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first… Continue reading RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets
Team finds new approach to curbing cancer cell growth
Using a new approach, scientists at The Scripps Research Institute (TSRI) and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma. The new study focused on… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1nyThMW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios… Continue reading Team finds new approach to curbing cancer cell growth
Acute liver failure due to primary amyloidosis in a nephrotic syndrome: a swiftly progressive course
AL amyloidosis is a clonal plasma cell proliferative disorder characterised by extracellular tissue deposits of insoluble fibrils derived from or immunoglobulin light chains. The most common organs affected by AL amyloidosis are the kidney, presenting with nephrotic syndrome and/or progressive renal dysfunction, and the heart, with restrictive cardiomyopathy. Hepatic deposition of fibrils occurs in half… Continue reading Acute liver failure due to primary amyloidosis in a nephrotic syndrome: a swiftly progressive course
How cancer cells fuel their growth
Cancer cells are notorious for their ability to divide uncontrollably and generate hordes of new tumour cells. Most of the fuel consumed by these rapidly proliferating cells is glucose, a type of sugar. Scientists had believed that most of the cell mass… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1R8YTeM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos… Continue reading How cancer cells fuel their growth
De Gruyter and National Defense Industry Press Sign Partnership Agreement
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RSvvGD via IFTTT
Researchers find highly active gene in aggressive human lung cancer
Scientists believe that “conserved” genes — those found in life forms that range from bacteria to plants, insects and humans — perform vital biological functions across species. And limited research on one of those genes, Nitrilase 1 (Nit1), suggested… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1nyTeRg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete… Continue reading Researchers find highly active gene in aggressive human lung cancer
SF Raises Tobacco Purchase Age to 21 – San Francisco Foghorn
SF Raises Tobacco Purchase Age to 21 San Francisco Foghorn We all know it causes multiple types of cancer, including cancers in the lungs, stomach, liver, esophagus, and larynx; it also can lead to chronic bronchitis, stroke, heart disease, and many other health risks. So for many smokers under the age of 21 … and… Continue reading SF Raises Tobacco Purchase Age to 21 – San Francisco Foghorn
Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.
Related Articles *Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.* J Am Chem Soc. 2016 Mar 8; Authors: Nguyen MH, Imanishi M, Kurogi T, Smith AB Abstract Anion relay chemistry (ARC), an effective, multicomponent union tactic, was successfully employed for the total synthesis of the highly cytotoxic marine macrolide (-)-mandelalide A (1). The northern hemisphere was constructed via a new type II ARC/CuCN cross-coupling tactic, while the southern hemisphere was secured via a highly efficient ...περισσότερα »
Functional characterisation of letter-specific responses in time, space and current polarity using magnetoencephalography
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): L. Gwilliams, G.A. Lewis, A. Marantz Recent neurophysiological evidence suggests that a hierarchical neural network of low-to-high level processing subserves written language comprehension. While a considerable amount of research has identified distinct regions and stages of processing, the relations between them and to this hierarchical model remain unclear. Magnetoencephalography (MEG) is a technique frequently employed in such investigations; however, no studies have sought to test whe... περισσότερα »
Neuroimaging measures of error-processing: Extracting reliable signals from event-related potentials and functional magnetic resonance imaging
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Vaughn R. Steele, Nathaniel E. Anderson, Eric D. Claus, Edward M. Bernat, Vikram Rao, Michal Assaf, Godfrey D. Pearlson, Vince D. Calhoun, Kent A. Kiehl Error-related brain activity has become an increasingly important focus of cognitive neuroscience research utilizing both event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI). Given the significant time and resources required to collect these data, it is important for researchers to plan their experiments such ... περισσότερα »
Alertness function of thalamus in conflict adaptation
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Xiangpeng Wang, Xiaoyue Zhao, Gui Xue, Antao Chen Conflict adaptation reflects the ability to improve current conflict resolution based on previously experienced conflict, which is crucial for our goal-directed behaviors. In recent years, the roles of alertness are attracting increasing attention when discussing the generation of conflict adaptation. However, due to the difficulty of manipulating alertness, very limited progress has been made in this line. Inspired by that color may affec... περισσότερα »
Language structure in the brain: A fixation-related fMRI study of syntactic surprisal in reading
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): John M. Henderson, Wonil Choi, Matthew W. Lowder, Fernanda Ferreira How is syntactic analysis implemented by the human brain during language comprehension? The current study combined methods from computational linguistics, eyetracking, and fMRI to address this question. Subjects read passages of text presented as paragraphs while their eye movements were recorded in an MRI scanner. We parsed the text using a probabilistic context-free grammar to isolate syntactic difficulty. Syntactic dif...περισσότερα »
Causal evidence of the involvement of the number form area in the visual detection of numbers and letters
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Mareike Grotheer, Géza Gergely Ambrus, Gyula Kovács Recent research suggests the existence of a visual area selectively processing numbers in the human inferior temporal cortex (number form area (NFA); Abboud et al., 2015; Grotheer et al., 2016; Shum et al., 2013). The NFA is thought to be involved in the preferential encoding of numbers over false characters, letters and non-number words (Grotheer et al., 2016; Shum et al., 2013), independently of the sensory modality (Abboud et al., 2015...περισσότερα »
Different partial volume correction methods lead to different conclusions: An 18F-FDG-PET study of aging
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Douglas N. Greve, David H. Salat, Spencer L. Bowen, David Izquierdo-Garcia, Aaron P. Schultz, Ciprian Catana, J. Alex Becker, Claus Svarer, Gitte M. Knudsen, Reisa A. Sperling, Keith A. Johnson A cross-sectional group study of the effects of aging on brain metabolism as measured with 18F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) using 99...περισσότερα »
A ventral salience network in the macaque brain
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Alexandra Touroutoglou, Eliza Bliss-Moreau, Jiahe Zhang, Dante Mantini, Wim Vanduffel, Bradford C. Dickerson, Lisa Feldman Barrett Successful navigation of the environment requires attending and responding efficiently to objects and conspecifics with the potential to benefit or harm (i.e., that have value). In humans, this function is subserved by a distributed large-scale neural network called the "salience network". We have recently demonstrated that there are two anatomically and functi...περισσότερα »
Removing inter-subject technical variability in magnetic resonance imaging studies
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Jean-Philippe Fortin, Elizabeth M. Sweeney, John Muschelli, Ciprian M. Crainiceanu, Russell T. Shinohara Magnetic resonance imaging (MRI) intensities are acquired in arbitrary units, making scans non-comparable across sites and between subjects. Intensity normalization is a first step for the improvement of comparability of the images across subjects. However, we show that unwanted inter-scan variability associated with imaging site, scanner effect, and other technical artifacts is still ...περισσότερα »
Inter-individual variation in fronto-temporal connectivity predicts the ability to learn different types of associations
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Kylie H. Alm, Tyler Rolheiser, Ingrid R. Olson The uncinate fasciculus connects portions of the anterior and medial temporal lobes to the lateral orbitofrontal cortex, so it has long been thought that this limbic fiber pathway plays an important role in episodic memory. Some types of episodic memory are impaired after damage to the uncinate, while others remain intact. Because of this, the specific role played by the uncinate fasciculus in episodic memory remains undetermined. In the pres... περισσότερα »
Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging
Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Douglas C. Dean, Jonathan O'Muircheartaigh, Holly Dirks, Brittany G. Travers, Nagesh Adluru, Andrew L. Alexander, Sean C.L. Deoni Optimal myelination of neuronal axons is essential for effective brain and cognitive function. The ratio of the axon diameter to the outer fiber diameter, known as the g-ratio, is a reliable measure to assess axonal myelination and is an important index reflecting the efficiency and maximal conduction velocity of white matter pathways. Although advanced neuroimaging techniques includ... περισσότερα »
Dynamic neural mechanisms underlie race disparities in social cognition
[image: S10538119.gif] Publication date: 15 May 2016 *Source:*NeuroImage, Volume 132 Author(s): Brittany S. Cassidy, Anne C. Krendl Race disparities in behavior may emerge in several ways, some of which may be independent of implicit bias. To mitigate the pernicious effects of different race disparities for racial minorities, we must understand whether they are rooted in perceptual, affective, or cognitive processing with regard to race perception. We used fMRI to disentangle dynamic neural mechanisms predictive of two separable race disparities that can be obtained from a trustwort... περισσότερα »
A case of a large splenic epithelial cyst
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1SBNYcP via IFTTT
A rising trend in the incidence of advanced gastric cancer in young Hispanic men
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Gastric Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1phSim4 via IFTTT
Tobacco smoking is not associated with accelerated liver disease in HIV-Hepatitis C Co-infection: A longitudinal cohort analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Open Forum Infectious Diseases from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1p9TDe2 via IFTTT
Exploratory analysis on overall survival after either surgery or stereotactic radiotherapy for lung oligometastases from colorectal cancer
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Clinical Oncology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1phSkKX via IFTTT
Proton pump inhibitor therapy for the treatment of laryngopharyngeal reflux: a meta-analysis of randomized controlled trials
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Clinical Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1p9TCH6 via IFTTT
GS-9857 in patients with chronic hepatitis C virus genotype 1–4 infection: a randomized, double-blind, dose-ranging phase 1 study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Viral Hepatitis from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5Add via IFTTT
Inflammatory bowel disease in pregnancy: A population-based study of prevalence and pregnancy outcomes
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
BJOG: An International Journal of Obstetrics and Gynaecology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WbcwIC via IFTTT
Nomogram for predicting lymph node metastasis rate of submucosal gastric cancer by analyzing clinicopathological characteristics associated with lymph node metastasis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Chinese Journal of Cancer Research from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5z9b via IFTTT
Risk of vascular thrombotic events following discontinuation of antithrombotics after peptic ulcer bleeding
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Clinical Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Wbcv7p via IFTTT
Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Hepatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5Ad5 via IFTTT
Fluorouracil-based preoperative chemoradiotherapy with or without oxaliplatin for stage II/III rectal cancer: a 3-year follow-up study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Chinese Journal of Cancer Research from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WbcwrZ via IFTTT
Utility of esophagram versus high-resolution manometry in the detection of esophageal dysmotility
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Otolaryngology - Head and Neck Surgery from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5z90 via IFTTT
Identification of a serum transglutaminase threshold value for the noninvasive diagnosis of symptomatic adult celiac disease patients: A retrospective study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Wbcwbx via IFTTT
Association of vitamin D level with clinical status in inflammatory bowel disease: A 5-year longitudinal study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
The American Journal of Gastroenterology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5xhn via IFTTT
Chronic vagus nerve stimulation in Crohn's disease: A 6-month follow-up pilot study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Neurogastroenterology & Motility from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WbcuAs via IFTTT
Multicenter clinical evaluation of the new 3rd generation assay for detection of antibodies against hepatitis C virus on the VIDAS system
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Journal of Clinical Virology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5ySG via IFTTT
What is the likelihood of colorectal cancer when surgery for ulcerative colitis associated dysplasia is deferred?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Colorectal Disease from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WbcvUV via IFTTT
Modeling how substitution of sedentary behavior with standing or physical activity is associated with health-related quality of life in colorectal cancer survivors
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Cancer Causes and Control from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5x10 via IFTTT
Influence of sorafenib and bevacizumab on pancreatic volume - A monocentric CT based analysis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Pancreatology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1WbcvEw via IFTTT
Minimizing the acquisition time for intravoxel incoherent motion magnetic resonance imaging acquisitions in the liver and pancreas
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Investigative Radiology from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1Le5x0S via IFTTT
Derived neutrophil lymphocyte ratio is predictive of survival from intermittent therapy in advanced colorectal cancer: A post hoc analysis of the MRC COIN study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
British Journal of Cancer from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1RStwlw via IFTTT
Evaluation of the HystSim™-virtual reality trainer: an essential additional tool to train hysteroscopic skills outside the operation theater
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Background Minimally invasive surgery is a major pillar of gynecological surgery. However, there are very few training opportunities outside the operation theater (OR) due to the cost and equipment requirements of organ simulators, virtual reality trainers (VRT) are promising tools to fill this gap. Methods Experienced and inexperienced participants of a minimally invasive surgery course followed the standardized HystSim™-VRT training program. Results Performance of 39 Participants (15 inexperienced and 24 experienced) was evaluated in the standardized hysteroscopic pro... περισσότερα »
Perioperative spleen embolization as a useful tool in laparoscopic splenectomy for simple and massive splenomegaly in children: a prospective study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract Objective The purpose of this prospective study is to evaluate the efficiency of perioperative spleen embolization prior to laparoscopic splenectomy indicated for hypersplenism. Methods We conducted a prospective study exploring a technique combining ultra-selective perioperative embolization and splenectomy. Between January 2008 and March 2013, 16 splenectomies were performed in children suffering from hypersplenism due to varying hematologic diseases. Spleen embolization was performed by an interventional radiologist in the operating room (OR) just before splenectomy a...περισσότερα »
Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.
[image: http:--frontlinemedcom.com-images-logos-] Related Articles *Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.* Cutis. 2016 Jan;97(1):24-7 Authors: Vega F, Ramos T, Las Heras P, Blanco C Abstract Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is no... περισσότερα »
Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.
[image: http:--http://ift.tt/1pyInbA] Related Articles *Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.* J Gen Virol. 2016 Feb 23; Authors: Iheozor-Ejiofor RP, Levanov L, Hepojoki J, Strandin T, Lundkvist Å, Plyusnin A, Vapalahti O Abstract Puumala virus (PUUV) grows slowly in cell culture. To study antigenic properties of PUUV an amenable method for their expression would be beneficial. To achieve this a replication-defective recombinant vesicular stomat... περισσότερα »
Epidemiology of Polypharmacy and Potential Drug-Drug Interactions Among Pediatric Patients in ICUs of U.S. Children's Hospitals.
Objectives: Polypharmacy is common in hospitalized children in the United States and has been identified as a major risk factor for exposure to potential drug-drug interactions. Little is known about the characteristics and prevalence of exposure of pediatric patients to polypharmacy and potential drug-drug interactions in PICUs. Design: Retrospective cohort study using the Pediatric Health Information System database. Setting: Forty-two freestanding children's hospitals throughout the United States. Patients: A total of 54,549 patients less than 18 years old cared for in PICUs in 2... περισσότερα »
PICU Volume and Outcome: A Severity-Adjusted Analysis.
Objectives: To determine the relationship between PICU volume and severity-adjusted mortality in a large, national dataset. Design: Retrospective cohort study. Setting: The VPS database (VPS, LLC, Los Angeles, CA), a national multicenter clinical PICU database. Patients: All patients with discharge dates between September 2009 and March 2012 and valid Pediatric Index of Mortality 2 and Pediatric Risk of Mortality III scores, who were not transferred to another ICU and were seen in an ICU that collected at least three quarters of data. Interventions: None. Measurements and Main Resul...περισσότερα »
Racial disparities in emergency general surgery: Do differences in outcomes persist among universally insured military patients?.
Background: Racial disparities in surgical care are well described. As many minority patients are also uninsured, increasing access to care is thought to be a viable solution to mitigate inequities. The objectives of this study were to determine whether racial disparities in 30/90/180-day outcomes exist within a universally insured population of military/civilian-dependent EGS patients and ascertain whether differences in outcomes differentially persist in care received at military versus civilian hospitals and among sponsors who are enlisted-service members versus officers. It also... περισσότερα »
Laparotomy: The conquering of the abdomen and the historical journey of pancreatic and duodenal injuries.
Objective: Describe the barriers to conquering the abdomen by exploratory laparotomy and the historical journey beginning with the original descriptions of pancreatic and duodenal injuries. Background: Unlike cardiac injuries described in the Iliad, pulmonary injuries described by Galen in gladiators and esophageal injuries described in the Edwin Smith Surgical Papyrus; pancreatic and duodenal injuries are relative newcomers to the Annals of Surgical History with their initial descriptions dating back to the 19th Century. Methods: Review of historical literature. Results: Pancreatic... περισσότερα »
Perioperative risk factors impact outcomes in emergency versus non-emergency surgery differently - Time to separate our national risk-adjustment models?.
Background: Emergency surgery (ES) is acknowledged to be riskier than Non-Emergency Surgery (NES). Yet, little is known about the relative impact of individual perioperative risk factors on 30-day outcomes in ES vs. NES. Methods: Using the 2011-2012 ACS-NSQIP nationwide database, the 20 most common ES procedures were identified by CPT code. CPT codes with from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QISNzG via IFTTT
The role of the sensor kinase, QseC, an adrenergic receptor of Escherichia coli, in bacterial translocation during hemorrhagic shock.
BACKGROUND: Hemorrhagic shock results in ileal mucosa damage and intestinal bacterial translocation. Additionally, during hemorrhagic shock, norepinephrine levels increase. Past research has shown that the QseC sensor kinase of Escherichia coli modulates the quorum-sensing response to epinephrine and norepinephrine. Therefore, the aim of our study was to examine whether the absence of the ability of E. coli to sense epinephrine/norepinephrine would attenuate the bacterial translocation to extraintestinal organs in a rat model of hemorrhagic shock. METHODS: An E. coli MC1000 qseC mut... περισσότερα »
Safety of minimizing pre-operative starvation in critically-Ill and intubated trauma patients.
Background: Cessation of enteral nutrition prior to an operation/procedure is the most common reason for feeding interruption in critically-ill trauma patients and contributes to substantial calorie deficits. This study reports on a strategy to increase calorie intake by continuing feeds until transfer for operations/procedures. Methods: Nutrition guidelines were modified in 2006 to allow continuation of feeding in intubated patients up until transfer to the operating room. Prior to 2006, enteral feeding was stopped at least 6 hours prior to surgery. A retrospective cohort design fr... περισσότερα »
Prevention of fall-related injuries in the elderly: An eastern association for the surgery of trauma practice management guideline.
Background: Fall-related injuries among the elderly (age 65 and older) are the cause of nearly 750,000 hospitalizations and 25,000 deaths per year in the United States, yet prevention research is lagging. Using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) methodology, the Eastern Association for the Surgery of Trauma produced this practice management guideline to answer the following injury prevention related PICO (Population, Intervention, Comparator, Outcomes) questions: PICO 1: Should bone mineral enhancing agents be used to prevent fall-related ... περισσότερα »
Antibiotics for appendicitis! Not so fast.
Introduction: Emerging literature in acute appendicitis favors the non-operative management of acute appendicitis. However, the actual use of this practice on a national level is not assessed. The aim of this study was to assess the changing trends in non-operative management of acute appendicitis and its effects on patient outcomes. Methods: We did an 8-year (2004-2011) retrospective analysis of National Inpatient Sample (NIS) database. We included all in-patients with the diagnosis of acute appendicitis. Patients diagnosed with appendiceal abscess or patients who underwent surgery... περισσότερα »
Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study.* Clin Oral Implants Res. 2016 Feb 26; Authors: Rokn A, Aslroosta H, Akbari S, Najafi H, Zayeri F, Hashemi K Abstract OBJECTIVES: This retrospective cross-sectional study aimed to evaluate the prevalence of biologic complications of implants in patients treated by fixed implant supported prosthesis without regular maintenance program. MATERIALS AND METHODS: One hundred thirty-four... περισσότερα »
Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.
[image: http:--frontlinemedcom.com-images-logos-] Related Articles *Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.* Cutis. 2016 Jan;97(1):24-7 Authors: Vega F, Ramos T, Las Heras P, Blanco C Abstract Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is no... περισσότερα »
Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.
[image: http:--http://ift.tt/1pyInbA] Related Articles *Vaccinia virus-free rescue of Fluorescent replication-defective Vesicular Stomatitis virus and pseudotyping with Puumala virus glycoproteins for use in neutralization tests.* J Gen Virol. 2016 Feb 23; Authors: Iheozor-Ejiofor RP, Levanov L, Hepojoki J, Strandin T, Lundkvist Å, Plyusnin A, Vapalahti O Abstract Puumala virus (PUUV) grows slowly in cell culture. To study antigenic properties of PUUV an amenable method for their expression would be beneficial. To achieve this a replication-defective recombinant vesicular stomat... περισσότερα »
Clinical evaluation of specific oral and salivary findings of coeliac disease in eastern Turkish paediatric patients.
Related Articles *Clinical evaluation of specific oral and salivary findings of coeliac disease in eastern Turkish paediatric patients.* Eur J Paediatr Dent. 2016 Mar;17(1):53-6 Authors: Dane A, Gürbüz T Abstract AIM: The aim of this study was to evaluate enamel defects (EDs), recurrent aphthous stomatitis (RAS) and salivary findings in Eastern Turkish children with coeliac disease (CD), and to compare the results with healthy children. MATERIALS AND METHODS: STUDY DESIGN: 70 children (35 CD patients and 35 healthy patients) aged between 5 to 15 years were included in this study. ... περισσότερα »
Inhibition of multispecies biofilms by a fluoride-releasing dental prosthesis copolymer.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Inhibition of multispecies biofilms by a fluoride-releasing dental prosthesis copolymer.* J Dent. 2016 Mar 3; Authors: Yassin SA, German MJ, Rolland SL, Rickard AH, Jakubovics NS Abstract OBJECTIVES: This study aimed to develop a new mixed-species acidogenic biofilm model and use it to assess the antimicrobial properties of a novel fluoride-releasing copolymer. METHODS: Stubs composed of a copolymer of methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA) with polymethyl methacrylate (PMMA) were produc... περισσότερα »
Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Mucositis in head and neck cancer patients treated with radiotherapy and systemic therapies: Literature review and consensus statements.* Crit Rev Oncol Hematol. 2016 Feb 1; Authors: De Sanctis V, Bossi P, Sanguineti G, Trippa F, Ferrari D, Bacigalupo A, Ripamonti CI, Buglione M, Pergolizzi S, Langendjik JA, Murphy B, Raber-Durlacher J, Russi EG, Lalla RV Abstract BACKGROUND: Oral mucositis (OM) due to radiotherapy and systemic therapies in head and neck cancer treatment represents a major problem causing a wide ... περισσότερα »
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.* Cell Rep. 2016 Mar 2; Authors: Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, Morrison C, Heise MT, He W, Miller MS, Lin X Abstract Host response to RNA virus infection is sensed by RNA sensors such as RIG-I, which induces MAVS-mediated NF-κB and IRF3 activation to promote inflammatory and antiviral responses, respectively. Here, we have found that CARMA3, a scaffold protein previously shown to medi... περισσότερα »
Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: A retrospective case series.
Related Articles *Long-term outcomes of oral rehabilitation with dental implants in HIV-positive patients: A retrospective case series.* Med Oral Patol Oral Cir Bucal. 2016 Mar 6;:0 Authors: Gay-Escoda C, Pérez-Álvarez D, Camps-Font O, Figueiredo R Abstract BACKGROUND: The existing information on oral rehabilitations with dental implants in VIH-positive patients is scarce and of poor quality. Moreover, no long-term follow-up studies are available. Hence, the aims of this study were to describe the long-term survival and success rates of dental implants in a group of HIV-positive ... περισσότερα »
Soft Tissue Necrosis in Head and Neck Cancer Patients After Transoral Robotic Surgery or Wide Excision With Primary Closure Followed by Radiation Therapy.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *Soft Tissue Necrosis in Head and Neck Cancer Patients After Transoral Robotic Surgery or Wide Excision With Primary Closure Followed by Radiation Therapy.* Medicine (Baltimore). 2016 Mar;95(9):e2852 Authors: Yun Hee L, Kim YS, Chung MJ, Yu M, Jung SL, Yoo IeR, Lee YS, Kim MS, Sun DI, Kang JH Abstract Risk factors were evaluated for surgical bed soft tissue necrosis (STN) in head and neck cancer patients treated with postoperative radiation therapy (PORT) after transoral robotic surgery (TORS) or wide excision wit... περισσότερα »
Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Effects of colchicine treatment on mean platelet volume and the inflammatory markers in recurrent aphthous stomatitis.* J Dermatolog Treat. 2016 Mar 4;:1-3 Authors: Seçkin HY, Bütün I, Baş Y, Takcı Z, Kalkan G Abstract OBJECTIVE: Recurrent aphthous stomatitis (RAS) is the most commonly seen inflammatory disease in the oral mucosa affecting 5%-25% of the general population. The etiology of RAS is still not fully understood and its treatment is very challenging. With its anti-inflammatory affects, colchicine is used for system... περισσότερα »
Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models.
[image: http:--http://ift.tt/1M8vfzn] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models.* Front Oncol. 2016;6:30 Authors: Walenta S, Mueller-Klieser W Abstract This review is focused on the radiobiology of carbon ions compared to X-rays using multicellular models of tumors and normal mucosa. The first part summarizes basic radiobiological effects, as observed in cancer cells. The second, mor... περισσότερα »
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Related Articles *UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.* Blood. 2016 Mar 3; Authors: Samudio I, Rezvani K, Shaim H, Hofs E, Ngom M, Bu L, Liu G, Lee JT, Imren S, Lam V, Poon GF, Ghaedi M, Takei F, Humphries K, Jia W, Krystal G Abstract Herein we demonstrate that oncolytic herpes simplex virus -1 (HSV-1) potently activates human peripheral blood mononuclear cells (PBMC) to lyse leukemic cell lines and primary acute myeloid leukemia samples, but not healthy allogeneic lymphocytes. Intriguingly, we found that ultraviolet light (UV)-inactivated H...περισσότερα »
Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.
[image: http:--production.springer.de-OnlineReso] Related Articles *Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system.* Arch Virol. 2016 Mar 3; Authors: Suda Y, Fukushi S, Tani H, Murakami S, Saijo M, Horimoto T, Shimojima M Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. The experimental use of CCHF virus (CCHFV), which causes CCHF, requires high-biosafety-level (BSL) containment. In contrast, ... περισσότερα »
Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Steamed root of Rehmannia glutinosa Libosch (Plantaginaceae) alleviates methotrexate-induced intestinal mucositis in rats.* J Ethnopharmacol. 2016 Feb 28; Authors: Shi CJ, Wen XS, Gao HF, Liu ZH, Xu XK, Li LF, Shen T, Xian CJ Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Intestinal mucositis induced by chemotherapy is a severe clinical problem in cancer patients that currently lack effective interventions. In traditional Chinese medicine, chemotherapeutic toxicity is diagnosed as Qi and Yin deficiency, and steamed reh... περισσότερα »
Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Adjuvant antifungal therapy using tissue tolerable plasma on oral mucosa and removable dentures in oral candidiasis patients: a randomised double-blinded split-mouth pilot study.* Mycoses. 2016 Mar 2; Authors: Preissner S, Kastner I, Schütte E, Hartwig S, Schmidt-Westhausen AM, Paris S, Preissner R, Hertel M Abstract Extended use of antimycotics in oral candidiasis therapy gives rise to problems related to fungal drug resistance. The aim of this pilot study was to investigate the efficacy of tissue tolerable plas... περισσότερα »
Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience.* Laryngoscope. 2016 Mar 1; Authors: Hazkani I, Rabinovics N, Limon D, Silvern D, Koren S, Hadar T, Bachar G, Shpitzer T, Popovtzer A Abstract OBJECTIVES/HYPOTHESIS: Despite advances in radiotherapy and chemotherapy treatments for head and neck cancers, the local failure rate is high. In most radiotherapy-resistant cases, surgery is performed; however, some cases are considered unresectable. No standard treatment... περισσότερα »
Structured review of papers reporting specific functions in patients with cancer of the head and neck: 2006 - 2013.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Structured review of papers reporting specific functions in patients with cancer of the head and neck: 2006 - 2013.* Br J Oral Maxillofac Surg. 2016 Feb 25; Authors: Rogers SN, Heseltine N, Flexen J, Winstanley HR, Cole-Hawkins H, Kanatas A Abstract Health-related quality of life (HRQoL) focuses on 4 core domains: physical and psychological function, social interaction, disease, and treatment-related symptoms, and is a key outcome in patients with cancer of the head and neck. We reviewed papers published between ... περισσότερα »
Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.
[image: http:--production.springer.de-OnlineReso] Related Articles *Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.* J Cancer Res Clin Oncol. 2016 Feb 26; Authors: Rabitsch W, Bojic M, Wohlfarth P, Leiner M, Schörgenhofer C, Kalhs P, Schulenburg A, Sillaber C, Mitterbauer M, Sperr WR, Jäger U, Skrabs K, Greinix H, Hermann A, Lamm W Abstract PURPOSE: Treatment of refractory Hodgkin disease deserves specific considerations. Recently, alemtuzumab-BEAM has been introduced in al... περισσότερα »
Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study.* Clin Oral Implants Res. 2016 Feb 26; Authors: Rokn A, Aslroosta H, Akbari S, Najafi H, Zayeri F, Hashemi K Abstract OBJECTIVES: This retrospective cross-sectional study aimed to evaluate the prevalence of biologic complications of implants in patients treated by fixed implant supported prosthesis without regular maintenance program. MATERIALS AND METHODS: One hundred thirty-four... περισσότερα »
Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.
[image: http:--frontlinemedcom.com-images-logos-] Related Articles *Concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis.* Cutis. 2016 Jan;97(1):24-7 Authors: Vega F, Ramos T, Las Heras P, Blanco C Abstract Concomitant allergic reactions to multiple drugs are uncommon. We report the case of a 66-year-old woman who presented with concomitant sensitization to inhaled budesonide and oral nystatin presenting as allergic contact stomatitis and systemic allergic contact dermatitis. It is no... περισσότερα »
Inter-individual variation in fronto-temporal connectivity predicts the ability to learn different types of associations
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 May 2016 Source:NeuroImage, Volume 132 Author(s): Kylie H. Alm, Tyler Rolheiser, Ingrid R. Olson The uncinate fasciculus connects portions of the anterior and medial temporal lobes to the lateral orbitofrontal cortex, so it has long been thought that this limbic fiber pathway plays an important role in episodic memory. Some types of […]
Mapping an index of the myelin g-ratio in infants using magnetic resonance imaging
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 May 2016 Source:NeuroImage, Volume 132 Author(s): Douglas C. Dean, Jonathan O’Muircheartaigh, Holly Dirks, Brittany G. Travers, Nagesh Adluru, Andrew L. Alexander, Sean C.L. Deoni Optimal myelination of neuronal axons is essential for effective brain and cognitive function. The ratio of the axon diameter to the outer fiber diameter, known as the g-ratio, […]
Dynamic neural mechanisms underlie race disparities in social cognition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: 15 May 2016 Source:NeuroImage, Volume 132 Author(s): Brittany S. Cassidy, Anne C. Krendl Race disparities in behavior may emerge in several ways, some of which may be independent of implicit bias. To mitigate the pernicious effects of different race disparities for racial minorities, we must understand whether they are rooted in perceptual, affective, […]
Atmosphere, Vol. 7, Pages 38: Effects of Strong East Asian Cold Surges on Improving the Air Quality over Mainland China
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A strong East Asian cold surge (SEACS) is one of the most distinct extreme weather events that can promote an improvement in local air quality. Combining East Asian atmospheric circulation with the air pollution index (API) datasets of 47 major cities throughout mainland China in 11 winter half-years (November–March) during 2001/2002–2011/2012, we investigated the influence […]
Atmosphere, Vol. 7, Pages 39: Characteristics of Preliminary Breakdown Pulses in Positive Ground Flashes during Summer Thunderstorms in Sweden
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This paper presents the characteristics of the preliminary breakdown pulses (PBP) in 51 positive ground flashes recorded during 2014 summer thunderstorms in Sweden. Electric field measurements were conducted remotely using a broadband antenna system (up to 100 MHz) for a recording length of 1 s with 200 ms trigger time. In the analysis, PBP trains […]
Pharmaceutics, Vol. 8, Pages 7: Liposome-Based Adjuvants for Subunit Vaccines: Formulation Strategies for Subunit Antigens and Immunostimulators
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The development of subunit vaccines has become very attractive in recent years due to their superior safety profiles as compared to traditional vaccines based on live attenuated or whole inactivated pathogens, and there is an unmet medical need for improved vaccines and vaccines against pathogens for which no effective vaccines exist. The subunit vaccine technology […]
In memoriam: the contributions to public health research of Farah Jamal, BA, MSc, PhD
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dr Farah Jamal’s death at the age of 30 is a tragic loss for public health research. Despite her youth, she made significant scientific contributions in understanding how to improve young people’s health and well-being, and through developing new methods that will help other researchers in the future. All her research was united by a […]
Fathers intelligence measured at age 18-20 years is associated with offspring smoking: linking the Swedish 1969 conscription cohort to the Swedish Survey of Living Conditions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background An association between lower IQ of parents, measured early in life, and smoking among their offspring has been reported. The extent to which other background factors account for this association is unknown. Methods Data on IQ, smoking, mental health, social class, parental divorce and social problems in a cohort of men born during 1949–1951 […]
Educational differentials in disability vary across and within welfare regimes: a comparison of 26 European countries in 2009
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Social differentials in disability prevalence exist in all European countries, but their scale varies markedly. To improve understanding of this variation, the article focuses on each end of the social gradient. It compares the extent of the higher disability prevalence in low social groups (referred to as disability disadvantage) and of the lower prevalence […]
The scientific bases to consider Parkinson’s disease an occupational disease in agriculture professionals exposed to pesticides in France
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Parkinson’s disease (PD) is the most common cause of parkinsonism and neurodegenerative disorder after Alzheimer’s disease. It is caused by the progressive loss of dopaminergic neurons of the substantia nigra pars compacta which is accompanied by the presence of Lewy bodies. Its diagnosis is clinical and there is a risk of misdiagnosis with other causes […]
Histiocytosis with mixed cell populations
from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1p9VQX3 via IFTTT
Reflectance confocal microscopy features of mycosis fungoides and Sézary syndrome: correlation with histopathologic and T-cell receptor rearrangement studies
Abstract Background Mycosis fungoides/Sézary syndrome (MF/SS) often requires multiple skin biopsies for definitive diagnosis. *In-vivo* reflectance confocal microscopy (RCM) visualizes high-resolution cellular detail of the skin. The objective of this study is to evaluate the morphologic features of MF/SS using RCM and to correlate RCM features with histopathology and T-cell receptor (TCR) gene rearrangement studies. Methods A cohort of patients with active/recurrent or suspicious MF/SS disease was prospectively recruited for RCM imaging and histopathologic/RCM images were evalu... περισσότερα »
Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study
Abstract Background The association of atypical nevi with melanoma and other forms of skin cancer has not been clearly defined. Methods We studied 631 patients with first lifetime diagnosis of mild, moderate, or severely atypical nevus from 2000 through 2005, identified through a population-based approach. Results Age at first diagnosis differed significantly between men and women (*P*<.001). Incidence rates peaked in the second through fourth decades in women and in the third, sixth, and seventh decades in men. From 2000 through 2005, the overall age- and sex-adjusted incidenc...περισσότερα »
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