Pediatric Phase I Ipilimumab
*Purpose:* Ipilimumab is a first-in-class immune checkpoint inhibitor approved for treatment of metastatic melanoma but not studied in children until this phase I protocol. *Experimental Design:* This study examined safety, pharmacokinetics, and immunogenicity, and immune correlates of ipilimumab administered to subjects ≤21 years old with recurrent or progressive solid tumors. Dose escalation cohorts received 1, 3, 5, or 10 mg/m2 intravenously every 3 weeks in a 3 + 3 design. Response was assessed after 6 weeks and 12 weeks, and then every 3 months. Treatment was continued until ...περισσότερα »
BRAF-CRAF Heterodimers in BRAF Inhibitor-Treated Tumors
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly progressing tumors distinct from these classic subtypes, such as lymph node metastas...περισσότερα »
BH3 Proteins Predict Response to BET Inhibition
Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic and gene-expression analyses of treatment-naive and engineered tolerant cell lines representing human melanoma and leukemia to elucidate the dominant features defining response to BETi. We... περισσότερα »
Comparative effectiveness and safety of infliximab and adalimumab in patients with ulcerative colitis
Summary Background Real-world comparative benefits and risks of infliximab (IFX) and adalimumab (ADA) in patients with ulcerative colitis (UC) are unclear. Aims To evaluate the comparative effectiveness and safety of IFX and ADA in patients with UC who were new users of anti-TNF agents. Methods Using an administrative claims database (Optum Labs Data Warehouse), we identified patients who received first anti-TNF (IFX, ADA) prescription after a 12-month period without any anti-TNF treatment (baseline), and with a minimum 6-month follow-up after anti-TNF initiation. Primary outcom...περισσότερα »
Anterior Restorations—Simple Technique
The post Anterior Restorations—Simple Technique appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1UvcsEo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Pediatric Phase I Ipilimumab
*Purpose:* Ipilimumab is a first-in-class immune checkpoint inhibitor approved for treatment of metastatic melanoma but not studied in children until this phase I protocol. *Experimental Design:* This study examined safety, pharmacokinetics, and immunogenicity, and immune correlates of ipilimumab administered to subjects ≤21 years old with recurrent or progressive solid tumors. Dose escalation cohorts received 1, 3, 5, or 10 mg/m2 intravenously every 3 weeks in a 3 + 3 design. Response was assessed after 6 weeks and 12 weeks, and then every 3 months. Treatment was continued until ...περισσότερα »
Novel compound heterozygous mutations in MYO7A gene associated with autosomal recessive sensorineural hearing loss in a Chinese family.
Novel compound heterozygous mutations in MYO7A gene associated with autosomal recessive sensorineural hearing loss in a Chinese family.: Int J Pediatr Otorhinolaryngol. 2016 Apr;83:179-85 Authors: Ma Y, Xiao Y, Zhang F, Han Y, Li J, Xu L, Bai X, Wang H Abstract OBJECTIVES: Mutations in MYO7A gene have been reported to be associated with Usher Syndrome type 1B (USH1B) and nonsyndromic hearing loss (DFNB2, DFNA11). Most mutations in MYO7A gene caused USH1B, whereas only a few reported mutations led to DFNB2 and DFNA11. The current study was designed to investigate the mutations among... περισσότερα »
BRAF-CRAF Heterodimers in BRAF Inhibitor-Treated Tumors
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly progressing tumors distinct from these classic subtypes, such as lymph node metastas...περισσότερα »
BH3 Proteins Predict Response to BET Inhibition
Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic and gene-expression analyses of treatment-naive and engineered tolerant cell lines representing human melanoma and leukemia to elucidate the dominant features defining response to BETi. We... περισσότερα »
Clonal Evolution Patterns in Tumor Vasculature
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that tumor blood vessels follow a pattern of dynamic clonal evolution. In an advanced melanoma tumor microenvironment, the vast majority of tumor vasculature clones are derived from a common precursor. Quantitative lineage analysis reveals founder clones diminish in frequency and are replaced by su... περισσότερα »
BRAF-CRAF Heterodimers in BRAF Inhibitor-Treated Tumors
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly progressing tumors distinct from these classic subtypes, such as lymph node metastas...περισσότερα »
BH3 Proteins Predict Response to BET Inhibition
Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic and gene-expression analyses of treatment-naive and engineered tolerant cell lines representing human melanoma and leukemia to elucidate the dominant features defining response to BETi. We... περισσότερα »
Clonal Evolution Patterns in Tumor Vasculature
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that tumor blood vessels follow a pattern of dynamic clonal evolution. In an advanced melanoma tumor microenvironment, the vast majority of tumor vasculature clones are derived from a common precursor. Quantitative lineage analysis reveals founder clones diminish in frequency and are replaced by su... περισσότερα »
BRAF-CRAF Heterodimers in BRAF Inhibitor-Treated Tumors
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly progressing tumors distinct from these classic subtypes, such as lymph node metastas...περισσότερα »
BH3 Proteins Predict Response to BET Inhibition
Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic and gene-expression analyses of treatment-naive and engineered tolerant cell lines representing human melanoma and leukemia to elucidate the dominant features defining response to BETi. We... περισσότερα »
Clonal Evolution Patterns in Tumor Vasculature
Although tumor blood vessels have been a major therapeutic target for cancer chemotherapy, little is known regarding the stepwise development of the tumor microenvironment. Here, we use a multicolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that tumor blood vessels follow a pattern of dynamic clonal evolution. In an advanced melanoma tumor microenvironment, the vast majority of tumor vasculature clones are derived from a common precursor. Quantitative lineage analysis reveals founder clones diminish in frequency and are replaced by su... περισσότερα »
BRAF-CRAF Heterodimers in BRAF Inhibitor-Treated Tumors
BRAF inhibitors (BRAFi) elicit therapeutic responses in metastatic melanoma, but alarmingly, also induce the formation of secondary benign and malignant skin tumors. Here, we report the emergence and molecular characterization of 73 skin and extracutaneous tumors in 31 patients who underwent BRAFi therapy. The majority of patients presented with classic epidermal tumors such as verrucous papillomas, keratoacanthomas, and squamous cell carcinomas (SCC). However, 15 patients exhibited new or rapidly progressing tumors distinct from these classic subtypes, such as lymph node metastas...περισσότερα »
BH3 Proteins Predict Response to BET Inhibition
Small-molecule inhibitors of the bromodomain and extraterminal (BET) family of proteins are being tested in clinical trials for a variety of cancers, but patient selection strategies remain limited. This challenge is partly attributed to the heterogeneous responses elicited by BET inhibition (BETi), including cellular differentiation, senescence, and death. In this study, we performed phenotypic and gene-expression analyses of treatment-naive and engineered tolerant cell lines representing human melanoma and leukemia to elucidate the dominant features defining response to BETi. We... περισσότερα »
Lateral balance demands
Attentional costs of walking are not affected by variations in lateral balance demands in young and older adults via Gait & Posture Publication date: Available online 11 March 2016 *Source:*Gait & Posture Author(s): Masood Mazaheri, Melvyn Roerdink, Jacques Duysens, Peter J. Beek, C. (Lieke) E. Peper Increased attentional costs of walking in older adults have been attributed to age-related changes in visuomotor and/or balance control of walking. The present experiment was conducted to examine the hypothesis that attentional costs of walking vary with lateral balance demands during walk... περισσότερα »
Auditory evoked potentials in the auditory system to prolonged sound stimuli
Auditory evoked potentials in the auditory system of a beluga whale Delphinapterus leucas to prolonged sound stimuli: [image: cm_sbs_024_plain.png] The effects of prolonged (up to 1500 s) sound stimuli (tone pip trains) on evoked potentials (the rate following response, RFR) were investigated in a beluga whale. The stimuli (rhythmic tone pips) were of frequencies of 45, 64, and 90 kHz at levels from 20 to 60 dB above threshold. Two experimental protocols were used: short- and long-duration. For the short-duration protocol, the stimuli were 500-ms-long pip trains that repeated at a ... περισσότερα »
Proteomic Characterization: HNSCC Patient-Derived Xenografts
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 38 δευτερόλεπτα
Despite advances in treatment approaches for head and neck squamous cell carcinoma (HNSCC), survival rates have remained stagnant due to the paucity of preclinical models that accurately reflect the human tumor. Patient-derived xenografts (PDX) are an emerging model system where patient tumors are implanted directly into mice. Increased understanding of the application and limitations of PDXs will facilitate their rational use. Studies to date have not reported protein profiles of PDXs. Therefore, we developed a large cohort of HNSCC PDXs and found that tumor take rate was not inf... περισσότερα »
Reference-Free Assessment of Speech Intelligibility Using Bispectrum of an Auditory Neurogram
Reference-Free Assessment of Speech Intelligibility Using Bispectrum of an Auditory Neurogram: Sensorineural hearing loss occurs due to damage to the inner and outer hair cells of the peripheral auditory system. Hearing loss can cause decreases in audibility, dynamic range, frequency and temporal resolution of the auditory system, and all of these effects are known to affect speech intelligibility. In this study, a new reference-free speech intelligibility metric is proposed using 2-D neurograms constructed from the output of a computational model of the auditory periphery. The resp... περισσότερα »
Inter-limb postural synchronization prior to bouts of postural instability
The effects of predictability on via Gait & Posture Publication date: Available online 11 March 2016 *Source:*Gait & Posture Author(s): Olinda Habib Perez, C. Jonathan Singer, George Mochizuki Anticipatory balance control optimizes balance reactions to postural perturbations. Predictive control is dependent on the ability of the central nervous system to modulate gain in accordance with specific task demands. Inter-limb synchronization is a sensitive measure of individual limb contributions to balance control and may reflect the coordination of gain modulation in preparation for insta...περισσότερα »
Word Recognition Variability With Cochlear Implants: The Degradation of Phonemic Sensitivity.
Word Recognition Variability With Cochlear Implants: The Degradation of Phonemic Sensitivity.: Objective: Cochlear implants (CIs) do not automatically restore speech recognition for postlingually deafened adults. Average word recognition remains at 60%, and enormous variability exists. Understanding speech requires knowledge of phonemic codes, the basic sound units of language. Hearing loss may result in degeneration of these long-term mental representations (i.e., "phonemic sensitivity"), and CI use may not adequately restore those representations. This investigation examined wheth...περισσότερα »
Cochlear Implantation in Neurobrucellosis.
Cochlear Implantation in Neurobrucellosis.: Balkan Med J. 2016 ;33(1):108-11 Authors: Bajin MD, Savaş Ö, Aslan F, Sennaroğlu L Abstract BACKGROUND: Neurobrucellosis is a disease consisting of a wide spectrum of complications such as peripheral neuropathy, cranial nerve involvement, ataxia, meningeal irritation, paraplegia, seizures, coma, and even death. The vestibulocochlear nerve seems to be the most commonly affected cranial nerve (10%). We present a patient with neurobrucellosis whose auditory perception and speech intelligibility skill performances improved after cochlear imp...περισσότερα »
Time-frequency decomposition of click evoked otoacoustic emissions in children
Time-frequency decomposition of click evoked otoacoustic emissions in children via Hearing Research [image: S03785955.gif] Publication date: Available online 11 March 2016 *Source:*Hearing Research Author(s): Srikanta K. Mishra, Milan Biswal Determining the time-frequency distributions of click-evoked otoacoustic emissions (CEOAEs) are scientifically and clinically relevant because of their relationship with cochlear mechanisms. This study investigated the time-frequency properties of CEOAEs in 5 to 10 year old children. In the first part, we examined the feasibility of the S transfo... περισσότερα »
Presence of hepatitis C (HCV) infection in Baby Boomers with Medicare is independently associated with mortality and resource utilisation
Summary Background Hepatitis C virus is common among Baby Boomers (BB). As this cohort ages, they will increasingly become Medicare eligible. Aim To evaluate resource utilisation and mortality of BB-Medicare recipients with HCV. Methods We used in-patient and out-patient Medicare databases (2005–2010). HCV was identified using ICD-9 codes. Outcomes included resource utilisation [payment/case and in-patient length of stay (LOS)] and short-term mortality. Results Of 1 153 862 BB Medicare recipients (2005–2010), 3.2% (*N* = 37 365) had HCV. During this period, in-patient Medicare...περισσότερα »
These new articles for Molecular Endocrinology are available online
These new articles for Molecular Endocrinology are available online ------------------------------ Early Release Molecular Endocrinology ------------------------------ [image: Molecular Endocrinology masthead] ------------------------------ ------------------------------ Molecular Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Impaired 17,20-lyase activity in male mice lacking cytochrome b5 in Leydig cells Varun Sondhi, et al. | Molecular Endocrinology | Mar...περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells Anja Schrade, et al. | Endocrinology | Mar 14, 2016 -----------------------------... περισσότερα »
Kinase Alterations in Colorectal Carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Targeted therapy for metastatic colorectal carcinoma consists of anti-EGFR therapy for patients with RAS/RAF wild-type tumors. However, the response rate remains low, suggesting the presence of alternative drivers possibly also representing potential therapeutic targets. We investigated receptor tyrosine kinase (RTK) alterations and MAP2K1 (MEK1) mutations in a large cohort of colorectal carcinoma patients studied by […]
Proteomic Characterization: HNSCC Patient-Derived Xenografts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Despite advances in treatment approaches for head and neck squamous cell carcinoma (HNSCC), survival rates have remained stagnant due to the paucity of preclinical models that accurately reflect the human tumor. Patient-derived xenografts (PDX) are an emerging model system where patient tumors are implanted directly into mice. Increased understanding of the application and limitations of […]
Aspirin and Salicylic Acid Downregulate Cyclin A2/CDK2
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Data emerging from the past 10 years have consolidated the rationale for investigating the use of aspirin as a chemopreventive agent; however, the mechanisms leading to its anticancer effects are still being elucidated. We hypothesized that aspirin’s chemopreventive actions may involve cell-cycle regulation through modulation of the levels or activity of cyclin A2/cyclin-dependent kinase-2 (CDK2). […]
Selected Articles from This Issue
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1V8se92 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Targeting the Adaptive Hypoxic Response in Multiple Myeloma Cells
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Multiple myeloma is incurable and invariably becomes resistant to chemotherapy. Although the mechanisms remain unclear, hypoxic conditions in the bone marrow have been implicated in contributing to multiple myeloma progression, angiogenesis, and resistance to chemotherapy. These effects occur via adaptive cellular responses mediated by hypoxia-inducible transcription factors (HIF), and targeting HIFs can have anticancer effects […]
CAFs Regulate Collagen Cross-Linking
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how collagen cross-linking is regulated in epithelial tumors. To address this question, we used KrasLA1 mice, which develop lung adenocarcinomas from somatic activation of a KrasG12D allele. The lung tumors in KrasLA1 mice were highly fibrotic and contained cancer-associated fibroblasts […]
KRAS-Regulated miR-31 Modulates Invasion Migration
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Activating KRAS mutations are nearly ubiquitous in pancreatic cancer occurring in more than 95% of clinical cases. miRNAs are small noncoding RNAs that regulate gene expression by binding sequences within the 3’UTRs of target mRNAs. An integral role for miRNAs in cancer pathogenesis is well established; however, the role of miRNAs in KRAS-mediated tumorigenesis is […]
SGEF Promotes Glioblastoma Cell Survival
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors. Despite surgical removal followed by concomitant radiation and chemotherapy with the alkylating agent temozolomide, GB tumors develop treatment resistance and ultimately recur. Impaired response to treatment occurs rapidly, conferring a median survival of just fifteen months. Thus, it is necessary […]
Treatment effect on biases in size estimation in spider phobia
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Publication date: Available online 14 March 2016 Source:Biological Psychology Author(s): Youssef Shiban, Martina B. Fruth, Paul Pauli, Max Kinateder, Jonas Reichenberger, Andreas Mühlberger BackgroundThe current study investigates biases in size estimations made by spider-phobic and healthy participants before and after treatment.Method: Forty-one spider-phobic and twenty healthy participants received virtual reality (VR) exposure treatment and were […]
Editorial: The Good, The Bad and The Weird – TheJambar.com (subscription)
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
Editorial: The Good, The Bad and The Weird TheJambar.com (subscription) The Weird: The event was interrupted by a protester who found his way onto the press riser and held up a giant yellow sign announcing that Lebron James had salivary gland cancer caused by cell phone use. Why he thought this was the moment that […]
Pediatric Audiology : Audiology Pediatric Amplification Guideline.
Pediatric Audiology in North America: Current Clinical Practice and How It Relates to the American Academy of Audiology Pediatric Amplification Guideline.: J Am Acad Audiol. 2016 Mar;27(3):166-187 Authors: Moodie S, Rall E, Eiten L, Lindley G, Gordey D, Davidson L, Bagatto M, Scollie S Abstract BACKGROUND: There is broad consensus that screening and diagnosis of permanent hearing loss in children must be embedded within a comprehensive, evidence-based, family-centered intervention program. Clinical practice guidelines (CPGs) for pediatric hearing assessment and hearing aid verifi...περισσότερα »
Perrault syndrome is a rare autosomal recessive disorder characterised by sensorineural hearing loss (SNHL) in both sexes and primary ovarian insufficiency in 46, XX karyotype females. Biallelic variants in five genes are reported to be causative: HSD17B4, HARS2, LARS2, CLPP and C10orf2.
Expanding the Genotypic Spectrum of Perrault syndrome.: Clin Genet. 2016 Mar 11; Authors: Demain LA, Urquhart JE, O'Sullivan J, Williams SG, Bhaskar SS, Jenkinson EM, Lourenco CM, Heiberg A, Pearce SH, Shalev SA, Yue WW, Mackinnon S, Munro KJ, Newbury-Ecob R, Becker K, Kim MJ, O' Keefe RT, Newman WG Abstract Perrault syndrome is a rare autosomal recessive disorder characterised by sensorineural hearing loss (SNHL) in both sexes and primary ovarian insufficiency in 46, XX karyotype females. Biallelic variants in five genes are reported to be causative: HSD17B4, HARS2, LARS2, CLPP a... περισσότερα »
The Influence of Linguistic Proficiency on Masked Text Recognition Performance in Adults With and Without Congenital Hearing Impairment.
The Influence of Linguistic Proficiency on Masked Text Recognition Performance in Adults With and Without Congenital Hearing Impairment.: Objective: The authors first examined the influence of moderate to severe congenital hearing impairment (CHI) on the correctness of samples of elicited spoken language. Then, the authors used this measure as an indicator of linguistic proficiency and examined its effect on performance in language reception, independent of bottom-up auditory processing. Design: In groups of adults with normal hearing (NH, n = 22), acquired hearing impairment (AHI, ...περισσότερα »
Linguistic Masking Release in School-Age Children and Adults
Linguistic Masking Release in School-Age Children and Adults: Purpose This study assessed if 6- to 8-year-old children benefit from a language mismatch between target and masker speech for sentence recognition in a 2-talker masker. Method English sentence recognition was evaluated for English monolingual children (ages 6–8 years, n = 15) and adults (n = 15) in an English 2-talker and a Spanish 2-talker masker. A regression analysis with subject as a random variable was used to test the fixed effect of listener group and masker language and the interaction of these two effects. R... περισσότερα »
Enhancing Tissue in the Internal Auditory Canal After Retrosigmoid Vestibular Schwannoma Resection
Enhancing Tissue in the Internal Auditory Canal After Retrosigmoid Vestibular Schwannoma Resection: [image: image] No abstract available
Congenital Stapes Ankylosis in Children
Congenital Stapes Ankylosis in Children: Surgical Findings and Results in 35 Cases: [image: image]Objective: To evaluate surgical findings and hearing results in children undergoing middle ear surgery for congenital stapes ankylosis with or without other ossicular malformations (Teunissen and Cremers class I and class II malformations). Study Design: A nonrandomized, nonblinded case series of prospectively collected data. Setting: A tertiary referral center. Patients: Twenty-eight consecutive pediatric patients who underwent 35 surgical procedures for congenital stapes ankylosis... περισσότερα »
Blastomycosis of the Temporal Bone Mimicking Glomus Jugulare Tumor
Blastomycosis of the Temporal Bone Mimicking Glomus Jugulare Tumor: [image: image]No abstract available
Middle Ear Visualization With Endoscopy and Microscopy
Comparison of Middle Ear Visualization With Endoscopy and Microscopy: [image: image]Introduction: The primary goal of chronic ear surgery is the creation of a safe, clean dry ear. For cholesteatomas, complete removal of disease is dependent on visualization. Conventional microscopy is adequate for most dissection, but various subregions of the middle ear are better visualized with endoscopy. Objective: The purpose of the present study was to quantitatively assess the improved visualization that endoscopes afford as compared with operating microscopes. Methods: Microscopic and end...περισσότερα »
Repeated Postoperative Follow-up Diffusion-weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma
Repeated Postoperative Follow-up Diffusion-weighted Magnetic Resonance Imaging to Detect Residual or Recurrent Cholesteatoma: Objective: In our institution, follow-up diffusion-weighted imaging (DWI) after cholesteatoma surgery is performed at least twice. The aim of this study was to determine the yield of the second follow-up DWI (D-W MRI-2) in patients in whom the first postoperative DWI (D-W MRI-1) was negative for residual or recurrent cholesteatoma. Study Design: A retrospective analysis. Setting: Tertiary referral center. Patients: Patients were included if 1) they had at le...περισσότερα »
Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging
Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging: [image: image]Hypothesis: Whether the round window membrane (RWM) is permeable to iodine-based contrast agents (IBCA) is unknown; therefore, our goal was to determine if IBCAs could diffuse through the RWM using CT volume acquisition imaging. Introduction: Imaging of hydrops in the living human ear has attracted recent interest. Intratympanic (IT) injection has shown gadolinium's ability to diffuse through the RWM, enhancing the perilymphatic sp...περισσότερα »
Endoscopically Guided Transtympanic Balloon Catheter Dilatation of the Eustachian Tube: A Cadaveric Pilot Study
Endoscopically Guided Transtympanic Balloon Catheter Dilatation of the Eustachian Tube: A Cadaveric Pilot Study: [image: image] Objective: To assess the feasibility, safety, and efficacy of transtympanic balloon catheter dilatation of the Eustachian tube (ET) in a cadaver model. Patients and Interventions: A cadaveric study of 10 cadaver heads, which underwent unilateral transtympanic dilatation of the ET with a 3 × 20 mm balloon catheter with full endoscopic guidance and visualization. Results: Procedural safety was demonstrated, with no damage to any essential structures found. F...περισσότερα »
DTI Tractography of the Facial Nerve in Patients With Cerebellopontine Angle Tumors
Diffusion Tensor Imaging Tractography of the Facial Nerve in Patients With Cerebellopontine Angle Tumors: [image: image]Objective: To demonstrate the utility of diffusion tensor imaging (DTI) fiber tractography of the facial nerve in patients with cerebellopontine angle (CPA) tumors. Study Design: Prospective. Setting: Tertiary referral center. Patients: DTI technique was established in 113 patients without tumors and in 28 patients with CPA tumors. Subsequently, DTI results were compared with intraoperative findings in 21 patients with medium and large-sized tumors, treated surgic... περισσότερα »
Comprehensive genetic testing in the clinical evaluation of patients with hearing loss.
Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss.: Hum Genet. 2016 Mar 11; Authors: Sloan-Heggen CM, Bierer AO, Shearer AE, Kolbe DL, Nishimura CJ, Frees KL, Ephraim SS, Shibata SB, Booth KT, Campbell CA, Ranum PT, Weaver AE, Black-Ziegelbein EA, Wang D, Azaiez H, Smith RJ Abstract Hearing loss is the most common sensory deficit in humans, affecting 1 in 500 newborns. Due to its genetic heterogeneity, comprehensive diagnostic testing has not previously been completed in a large multiethnic cohort. To determine the aggregate contribution i... περισσότερα »
The peripheral–central chemoreflex interaction: where do we stand and what is the next step?
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Channelling frozen cells to survival after thawing: opening the door to cryo-physiology
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CO2 – friend or foe?
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Passing the baton
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Issue Information
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Renal lymph: a window for renal pathophysiology?
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A ‘passive’ movement into the future of assessing endothelial dysfunction?
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Autonomic and neuroendocrine dysfunction in chronic disease
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Ear Clicking
“Physiological” Ear Clicking: Its Origin and Potential Usability as a Test Tool for the Eustachian Tube Function: [image: image]Objective: To explore the origin of “physiological” ear clicks during deglutition or other pharyngeal movements, which, in contrast to disturbing frequent clicks under pathologic conditions, mostly remain unnoticed by the patient. Study Design: Clinical experimental study at a tertiary referral center. Methods: Ear clicks were recorded by a microphone sealing the external ear canal parallel to endoscopic or manometric evaluations of the Eustachian tube func... περισσότερα »
Assessment of Vestibulo-oculomotor Reflex in Ménière's Disease: Defining an Instrumental Profile
Assessment of Vestibulo-oculomotor Reflex in Ménière's Disease: Defining an Instrumental Profile: [image: image]Objectives: To analyze and compare, in two groups of patients affected by definite Ménière's disease (MD) but treated differently, the Video Head Impulse Test findings especially by putting them in relationship with canal paresis, hearing loss, and duration of the disease. Study Design: Retrospective chart review. Patients: Seventy patients affected by unilateral definite MD (16 in Group 1 and 54 in Group 2) observed between March 2014 and May 2015 in a tertiary referral ...περισσότερα »
Insertion of Cochlear Implant Electrode Array Using the Underwater Technique for Preserving Residual Hearing
Insertion of Cochlear Implant Electrode Array Using the Underwater Technique for Preserving Residual Hearing: [image: image]Objective: To describe a method of cochlear implantation in which the opening of the cochlea and the electrode array insertion are performed under water (underwater technique). Study Design: Retrospective patient review. Setting: Academic tertiary referral center. Patients: Fifteen implantations in children and adult patients with residual hearing at the frequencies 250, 500, and 1000 Hz on the unaided preoperative pure-tone audiometry were included in this st... περισσότερα »
Intraoperative Real-time Cochlear Response Telemetry Predicts Hearing Preservation in Cochlear Implantation
Intraoperative Real-time Cochlear Response Telemetry Predicts Hearing Preservation in Cochlear Implantation: [image: image] Aim: To monitor cochlear function during cochlear implantation and determine correlations with postoperative acoustic hearing. Background: Cochlear response telemetry measures cochlear function directly from cochlear implant electrodes. We have adapted this system to provide real-time cochlear response telemetry (RT-CRT) monitoring of a patient's acoustic hearing as the cochlear implant electrode array is inserted. Methods: Eighteen subjects (1 child and 17 ad... περισσότερα »
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours
Mandarin Tone Identification in Cochlear Implant Users Using Exaggerated Pitch Contours: Objective: To determine whether exaggerating the variations in fundamental frequency (F0) contours of Mandarin-based pitch fluctuations could improve tone identification by cochlear implant (CI) users. Methods: Twelve normal-hearing (NH) listeners and 11 CI users were tested for their ability to recognize F0 contours modeled after Mandarin tones, in 4- or 5-alternatives forced-choice paradigms. Two types of stimuli were used: computer-generated complex tones and voice recordings. Four contours w... περισσότερα »
Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder: Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling
Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder: [image: image]Hypothesis: Different missense mutations of the optic atrophy 1 gene (OPA1) identified in optic atrophy patients with auditory neuropathy spectrum disorder (ANSD) induce functional impairment through different molecular mechanisms. Background: OPA1 is the gene responsible for autosomal dominant optic atrophy (ADOA), but some of its mutations are also associated with ANSD. OPA1 is a member... περισσότερα »
MPR-CT Imaging for Stapes Prosthesis: Accuracy and Clinical Significance
MPR-CT Imaging for Stapes Prosthesis: Accuracy and Clinical Significance: [image: image]Objectives: The aims of this article are: 1) to re-evaluate the accuracy of multiple planar reconstruction computed tomography (MPR-CT) imaging on stapes-prosthesis parameters, and 2) to clarify possible relationships between prosthesis intravestibular depth and postoperative hearing outcomes. Patients: Seventy patients (46 women and 24 men; 32 right and 38 left sides) with the mean age of 40 years (range, 19–62 yr) with clinical otosclerosis. Intervention(s): All patients underwent stapedotom...περισσότερα »
Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation
Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation: [image: image]Objective: To investigate the clinical outcome of a surgical technique with tissue preservation for a wide bone-anchored hearing implant concerning postoperative complications, skin reactions, implant loss, and implant stability. Study Design: Consecutive, prospective case series. Setting: Tertiary referral center. Patients: Twenty-four adult patients with normal skin quality were enrolled. Intervention(s): Implantation of bone-anchored implant was perf... περισσότερα »
Lack of Evidence for Nonotosclerotic Stapes Fixation in Human Temporal Bone Histopathology
Lack of Evidence for Nonotosclerotic Stapes Fixation in Human Temporal Bone Histopathology: [image: image]Hypothesis: Nonotosclerotic stapes fixation does not represent a significant cause of stapes ankylosis in patients undergoing stapedectomy; the vast majority have otosclerosis. Background: Nonotosclerotic stapes fixation has been proposed as the diagnosis in 30 to 40% of patients undergoing stapedectomy (after excluding rare congenital, systemic, and syndromic causes of stapes fixation and tympanosclerosis). This finding was based on the histopathologic evaluation of total stape...περισσότερα »
Parallel-transmit-accelerated 2D Selective RF Excitation MR of the Temporal Bone: Enhanced Resolution of Labyrinthine and IAC Structures
Parallel-transmit-accelerated 2D Selective RF Excitation MR of the Temporal Bone: Enhanced Resolution of Labyrinthine and IAC Structures: Rationale and Objectives: The purpose of this study was to compare a standard T2 SPACE sequence (standard-SPACE) used in temporal bone imaging at 3 T with a new parallel-transmit-accelerated 2D-selective radio frequency excitation technique for SPACE which was either time-improved or resolution-improved. Materials and Methods: Thirty-two consecutive patients were examined in this IRB-approved study using a standard T2 SPACE sequence, and then a ti... περισσότερα »
Barotrauma-induced Pneumolabyrinth and Pneumocephalus Associated With Semicircular Canal Dehiscence
Barotrauma-induced Pneumolabyrinth and Pneumocephalus Associated With Semicircular Canal Dehiscence: [image: image] No abstract available
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis
Iatrogenic Phenol Injury Causing Facial Paralysis With Tympanic Membrane and Ossicular Necrosis: [image: image]Objective: To describe a serious iatrogenic injury and propose means of reducing the risk of its reoccurrence. Patients: A 21-year-old man who suffered facial paralysis, complete necrosis of the tympanic membrane, and ossicular discontinuity because of chemical burn from accidental application of copious amounts of topical anesthetic phenol into the ear. Interventions: Conservative management of facial paralysis and delayed reconstruction of the tympanic membrane and ossic... περισσότερα »
Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.
Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.: Radiother Oncol. 2016 Mar ; Authors: Dean JA, Welsh LC, McQuaid D, Wong KH, Aleksic A, Dunne E, Islam MR, Patel A, Patel P, Petkar I, Phillips I, Sham J, Newbold KL, Bhide SA, Harrington KJ, Gulliford SL, Nutting CM Abstract BACKGROUND AND PURPOSE: Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to improve these mod... περισσότερα »
Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis
Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis: *Conditions*: Nasopharyngeal Carcinoma; Radiation Therapy Complication *Interventions*: Drug: Atorvastatin; Other: Placebo *Sponsor*: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University ArmsAssigned Interventions Active Comparator: Atorvastatin Patients will take atorvastatin 20mg per night, totally 2 years. Drug: Atorvastatin Patients in this group will take 20mg per night. Other Names: - Atorvastatin Calcium Tablets - Lipitor Placebo Comparator: Placeb...περισσότερα »
Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer
Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer: *Conditions*: Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Sq...περισσότερα »
Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC
Tolerance and Efficacy of Pembrolizumab or Cetuximab Combined With RT in Patients With Locally Advanced HNSCC: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Pembrolizumab; Drug: Cetuximab; Radiation: Conventional Radiotherapy *Sponsor*: Groupe Oncologie Radiotherapie Tete et Cou ArmsAssigned Interventions Experimental: Pembrolizumab and radiotherapy 200 mg IV infusion every 3 weeks, i.e. on day 1, 22, 43 during the course of radiotherapy Drug: Pembrolizumab 200mg IV infusion every 3 weeks, i.e. on day 1, 22, 43 during the course of radi...περισσότερα »
Precaruncular approach to the medial orbit & landmarks for anterior ethmoidal artery ligation: A cadaveric study
Precaruncular approach to the medial orbit & landmarks for anterior ethmoidal artery ligation: A cadaveric study: Abstract Objective In epistaxis and skull base surgery, the anterior ethmoidal artery sometimes needs to be ligated. We describe a novel, quick and scar-free surgical technique to ligate this artery with salient landmarks allowing rapid identification. Patients and Methods Twenty medial orbital walls from 10 randomly selected fresh-frozen, non-formalinized cadaver heads were examined. Dissection was performed by a precaruncular external approach to expose the AEA in all ...περισσότερα »
Post-Surgical and Oncologic Outcomes of Supracricoid Partial Laryngectomy: A Single-Institution Report of Ninety Cases
Post-Surgical and Oncologic Outcomes of Supracricoid Partial Laryngectomy: A Single-Institution Report of Ninety Cases: *Objective:* The aim of this study was to report the post-surgical and oncologic outcomes of patients who underwent supracricoid partial laryngectomy (SCPL). *Methods:* 90 patients who underwent SCPL between 1994 and 2014 were reviewed. 45 patients underwent cricohyoidopexy (CHP) and 45 patients cricohyoidoepiglottopexy (CHEP). Median nasogastric (NG) tube removal time, decannulation time, overall survival, disease-free survival and local control rates were calcula... περισσότερα »
Presence of hepatitis C (HCV) infection in Baby Boomers with Medicare is independently associated with mortality and resource utilisation
Summary Background Hepatitis C virus is common among Baby Boomers (BB). As this cohort ages, they will increasingly become Medicare eligible. Aim To evaluate resource utilisation and mortality of BB-Medicare recipients with HCV. Methods We used in-patient and out-patient Medicare databases (2005–2010). HCV was identified using ICD-9 codes. Outcomes included resource utilisation [payment/case and in-patient length of stay (LOS)] and short-term mortality. Results Of 1 153 862 BB Medicare recipients (2005–2010), 3.2% (*N* = 37 365) had HCV. During this period, in-patient Medicare...περισσότερα »
Recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps
Prognostic factors for via Auris Nasus Larynx Publication date: Available online 14 March 2016 *Source:*Auris Nasus Larynx Author(s): Tsuguhisa Nakayama, Daiya Asaka, Hiroaki Kanaya, Akihito Kuboki, Shin-ichi Haruna ObjectiveIn this study, we aimed to clarify the prognostic factors affecting the ethmoid condition during a long-term follow-up after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).MethodsThirty-six patients with CRSwNP underwent surgery from December 2008 to February 2012. All surgeries were performed by one surgeon, and all p... περισσότερα »
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck
Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect—PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome: AbstractPTEN hamartoma tumor syndrome refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (*PTEN*) gene. Cowden syndrome, the principal PTEN-related disorder is characterized by multiple neoplasms and hamartomas, mucosal papillomatosis, and skin lesions, trichilemmomas. Trichilemmomas and mucocutaneous papillomatous papules are one of the first signs of the disease. Early recognitio... περισσότερα »
Xeroderma pigmentosum (XP) is a rare disorder of defective UV-radiation induced damage repair that is characterized by photosensitivity with easy skin burning following minimal sun exposure, early freckling and development of lentiginous pigmentation along with other features of poikiloderma and a propensity for developing skin cancer at an early age
Xeroderma Pigmentosum: AbstractXeroderma pigmentosum (XP) is a rare disorder of defective UV-radiation induced damage repair that is characterized by photosensitivity with easy skin burning following minimal sun exposure, early freckling and development of lentiginous pigmentation along with other features of poikiloderma and a propensity for developing skin cancer at an early age. In this short review, the clinical, pathological, genetic and molecular aspects of XP are reviewed in the current literature. XP encompasses a spectrum of disease that overlaps with other diseases of DNA... περισσότερα »
Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)
Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome): AbstractNevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of patients, and include keratocystic odontogenic tumors (formerly odontogenic keratocysts) as well as dyskeratotic palmar and plantar pitting. A range of skeletal and other developmental abnormalities are also often seen. The disorder is caused ...περισσότερα »
Brooke-Spiegler syndrome (BSS) is an inherited autosomal dominant disease characterized by the development of multiple adnexal cutaneous neoplasms most commonly spiradenoma, cylindroma, spiradenocylindroma, and trichoepithelioma. Multiple familial trichoepithelioma (MFT)
Brooke-Spiegler Syndrome and Phenotypic Variants: An Update: AbstractBrooke-Spiegler syndrome (BSS) is an inherited autosomal dominant disease characterized by the development of multiple adnexal cutaneous neoplasms most commonly spiradenoma, cylindroma, spiradenocylindroma, and trichoepithelioma. Multiple familial trichoepithelioma (MFT) is a phenotypic variant of the disease characterized by the development of numerous trichoepitheliomas (cribriform trichoblastoma) only. Malignant tumors arise in association with preexisting benign cutaneous neoplasms in about 5–10 % of the patie... περισσότερα »
Chemokine and chemokine receptors in HNSCC
Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review: Squamous cell carcinoma (SCC) is the most common malignancy of head and neck region arising from mucosal linings of the upper aerodigestive tract, comprising (1) nasal cavity and paranasal sinuses, (2) nasopharynx, (3) hypopharynx, larynx, and trachea, and (4) oral cavity and oropharynx [1,2]. Head and neck squamous cell carcinomas (HNSCC) are characterized by high morbidity and mortality rates and strong tendency to regional and distant metastasis [1–4]. These tumor charac...περισσότερα »
Subclinical Hyperthyroidism Is Associated with Decreased Risk for Recurrent Venous Thromboembolism
Subclinical Hyperthyroidism Is Associated with Decreased Risk for Recurrent Venous Thromboembolism: Clinical Thyroidology Mar 2016, Vol. 28, No. 3: 82-84. [image: Free first page]
Falling Levels of Thyroglobulin Antibody After Treatment for DTC Predict No Structural Recurrence
Falling Levels of Thyroglobulin Antibody After Treatment for DTC Predict No Structural Recurrence: Clinical Thyroidology Mar 2016, Vol. 28, No. 3: 79-81. [image: Free first page]
CT Is the Best Predictor of Whether Sternotomy Is Required for Resection of Substernal Goiter
Computed Tomography Is the Best Predictor of Whether Sternotomy Is Required for Resection of Substernal Goiter: Clinical Thyroidology Mar 2016, Vol. 28, No. 3: 72-74. [image: Free first page]
Resistance to Thyroid Hormone Due to a Mutation of the Thyroid Hormone Receptor α1
A Girl and Her Father Have Resistance to Thyroid Hormone Due to a Mutation of the Thyroid Hormone Receptor α1: Clinical Thyroidology Mar 2016, Vol. 28, No. 3: 68-71. [image: Free first page]
Differences in Clinical Fertility State Relate to Intracellular Gene Expression of Thyroid Hormone Receptors and Thyroid Function
Differences in Clinical Fertility State Relate to Intracellular Gene Expression of Thyroid Hormone Receptors and Thyroid Function: Clinical Thyroidology Mar 2016, Vol. 28, No. 3: 85-88. [image: Free first page]
Paukendrainage und Mittelohrbelüftung: Indikationen, Komplikationen und deren Behandlung
Paukendrainage und Mittelohrbelüftung: Indikationen, Komplikationen und deren Behandlung: Laryngo-Rhino-Otol 2016; 95: 171-177 DOI: 10.1055/s-0042-101604 Die Paukendrainage ist der häufigste chirurgische Eingriff in Deutschland überhaupt mit dem Ziel der Gewährleistung von Mittelohrventilation und Sekretabfluß aus der Paukenhöhle sowie sofortiger Hörverbesserung und Vermeidung von Komplikationen und Spätfolgen wie Trommelfell-, Paukenhöhlenpathologien und Entwicklungsbeeinträchtigungen. Die volkswirtschaftliche Bedeutung wird dadurch unterstrichen, dass in Deutschland etwa jährli... περισσότερα »
Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review
Publication date: May 2016 *Source:*Oral Oncology, Volume 56 Author(s): Janine Mayra da Silva, Danilo Figueiredo Soave, Tálita Pollyanna Moreira dos Santos, Aline Carvalho Batista, Remo Castro Russo, Mauro Martins Teixeira, Tarcília Aparecida da Silva Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or strom... περισσότερα »
The International Frontal Sinus Anatomy Classification (IFAC) and Classification of the Extent of Endoscopic Frontal Sinus Surgery (EFSS)
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The frontal recess and frontal sinus anatomy can vary from simple to complex. The variations in the anatomy of the frontal recess and frontal sinus are considerable but almost all variations can be classified if the various cell patterns are analyzed. This consensus document was developed to improve the ability of the surgeon to understand […]
RESOLVE: bioabsorbable steroid-eluting sinus implants for in-office treatment of recurrent sinonasal polyposis after sinus surgery: 6-month outcomes from a randomized, controlled, blinded study
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Patients with recurrent sinonasal polyposis after endoscopic sinus surgery (ESS) have limited treatment options. Safety and efficacy were previously reported for a bioabsorbable sinus implant that elutes mometasone furoate for 3 months. Here we summarize longer-term outcomes. Methods A randomized, controlled, blinded study with 100 chronic rhinosinusitis with nasal polyps (CRSwNP) patients who failed […]
Outcomes of modified endoscopic Lothrop in aspirin-exacerbated respiratory disease with nasal polyposis
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background Patients with aspirin-exacerbated respiratory disease (AERD) and chronic rhinosinusitis with nasal polyps (CRSwNP) are often reported to be recalcitrant to standard medical and surgical intervention. Failure rates of standard endoscopic sinus surgery in these patients are reported to be as high as 90%. We review the outcomes for our cohort of AERD patients undergoing […]
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