Tumour seeding in the surgical pathway after resection of skull base chordoma
Publication date: Available online 21 March 2016 *Source:*Reports of Practical Oncology & Radiotherapy Author(s): Marco Krengli, Arturo Poletti, Eleonora Ferrara, Piero Fossati AimThe aim of this study is to review the clinical series in which tumour seeding was reported after skull base surgery for chordomas.BackgroundThe occurrence of implantation of cancer cells during surgical procedures for the removal of chordoma is a rare event described by a number of authors in a few patient series and case reports.Materials and methodsLiterature search was performed by PubMed and Scopus by us...περισσότερα »
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.Hypnotic recovery after CPMM administration is context insensitive because its metabolite does not accumulate to hypnotic levels in the central nervous system. This reflects the very large potency ratio between CPMM and CPMM-CA and the resistance of CPMM to metabolism by esterases present in the brain.
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite: [image: image]BACKGROUND: Methoxycarbonyl etomidate (MOC-etomidate) and cyclopropyl methoxycarbonyl metomidate (CPMM) are rapidly metabolized “soft” etomidate analogs. CPMM’s duration of hypnotic effect is context insensitive, whereas MOC-etomidate’s is not. In this study, we tested the hypothesis that CPMM’s effect is context insensitive because, unlike MOC-etomidate, its metabolite fails to reach physiologically important concentrations i...περισσότερα »
Tranexamic Acid Compared with Placebo for Reducing Total Blood Loss
Tranexamic Acid Compared with Placebo for Reducing Total Blood Loss in Hip Replacement Surgery: A Randomized Clinical Trial: BACKGROUND: Tranexamic acid (TXA) reduces bleeding in patients undergoing hip replacement surgery, but optimal doses and timing have yet to be established. Our primary objective in this study was to assess total blood loss 48 hours after surgery with different regimens. METHODS: This was a multicenter, parallel-group, randomized, placebo-controlled clinical trial that included all ASA physical status I to III patients undergoing unilateral total hip replacemen...περισσότερα »
Implications of Patient Age and ASA Physical Status for Operating Room Management Decisions
Implications of Patient Age and ASA Physical Status for Operating Room Management Decisions: BACKGROUND: In elderly, high-risk patients, operating room (OR) turnaround times are especially difficult to estimate, and the managerial implications of patient age and ASA physical status for OR management decisions remain unclear. We hypothesized that evaluating patient age and ASA physical status in the right model would improve accuracy of turnaround time estimates and, thus, would have decisive implications for OR management. METHODS: By using various multivariate techniques, we modele... περισσότερα »
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis: BACKGROUND: Preoperative gabapentin has been shown to improve postoperative pain and limit reliance on opioid analgesia. On the basis of an alternative mechanism, our group investigated the ability of preoperative gabapentin to prevent postoperative nausea and vomiting (PONV). METHODS: We performed a meta-analysis of trials that reported outcomes on the effect of preoperative gabapentin on PONV end points in patients undergoing general anesthesia. In our primary analysis, we calculated the ... περισσότερα »
The Effect of Depth of Anesthesia on Emergence Agitation in Children
A Randomized Controlled Trial to Determine the Effect of Depth of Anesthesia on Emergence Agitation in Children: BACKGROUND: The cause of emergence agitation (EA) in children is unknown. Rapid emergence from inhaled anesthesia has been implicated because EA is more common with sevoflurane than with halothane. A dose-dependent effect of sevoflurane, which increases seizure-like electroencephalogram activity, has also been proposed. METHODS: To determine whether depth of anesthesia as measured by bispectral index (BIS) affects EA, 40 ASA physical status I to II children aged 2 to 8 ... περισσότερα »
The Effects of Ketamine on Cognitive Function in Elderly
The Effects of Ketamine on Cognitive Function in Elderly Patients Undergoing Ophthalmic Surgery: A Pilot Study: BACKGROUND: Acute postoperative cognitive dysfunction is characterized by neurocognitive dysfunction and confusion. In this study, we compared the cognitive status of a geriatric population undergoing ophthalmic surgery, as assessed by the Short Portable Mental Status Questionnaire (SPMSQ) before and after ketamine administration. METHODS: Eighty patients were enrolled and randomly assigned in a double-blind study to receive either ketamine (0.3 mg/kg dose) or physiologi...περισσότερα »
Pharyngeal Oxygen Insufflation During AirTraq Laryngoscopy Slows Arterial Desaturation in Infants and Small Children
Pharyngeal Oxygen Insufflation During AirTraq Laryngoscopy Slows Arterial Desaturation in Infants and Small Children: [image: image]BACKGROUND: The extent to which insufflation of oxygen into the posterior pharynx during laryngoscopy prolongs adequate saturation in infants and small children remains unknown. Therefore, we compared oxygen saturation over time in preoxygenated small children with and without posterior pharynx oxygen insufflation. METHODS: After induction of anesthesia with sevoflurane and propofol, infants and small children were preoxygenated with 100% oxygen for 3 ...περισσότερα »
Blood Products, Crystalloids, and Rapid Infusion
Blood Products, Crystalloids, and Rapid Infusion: An Experimental Study: [image: image] BACKGROUND: Electromagnetic coil overheating, deformation, occlusion, and rupture during rapid infuser use have been previously reported. Although the etiology is unclear, prolonged machine use and reconstitution of citrated blood components with crystalloid solutions in the reservoir have been implicated. Lactated Ringer’s (LR) solution is of particular concern as a diluent because of its calcium content. We sought to reproduce this failure mode using different infusion rates and different combi... περισσότερα »
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes [MUCOSAL IMMUNOLOGY]
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes [MUCOSAL IMMUNOLOGY]: In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU domain class 2–associating factor 1 (POU2AF1), a known transcription cofactor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human airway epithelial samples obtained by bronchoscopy and brushing was excluded by immunohistochemistry staining, the observation of upr... περισσότερα »
Multiple drug allergy
Multiple drug allergy: A 16-year-old nonatopic boy with recurrent tonsillitis was admitted to our drug safety clinic because of his history of drug allergy. More than 1 year before, he had an immediate hypersensitivity reaction after oral administration of amoxicillin. He developed rash, pruritus, and dyspnea 10 to 15 minutes after amoxicillin intake. Two months later, because of this adverse event, the patient began taking clarithromycin as an alternative, safe antibiotic. He developed general urticaria 30 minutes after intake.
Safety of chitosan processed wine in shrimp allergic patients
Safety of chitosan processed wine in shrimp allergic patients: Wine is an ubiquitous product all over the world, but up to 1 in 10 consumers reports intolerance or allergy-like symptoms after drinking wine.1 Chitosan is a linear polysaccharide and the product of the deacetylation of chitin, the main component of the cell walls of some fungi; the exoskeletons of arthropods, such as crustaceans and insects; and the beaks of cephalopods.2 It also may be used in wine processing.
Salivary cotinine measurement for all children with persistent asthma
Salivary cotinine measurement for all children with persistent asthma: spit matters: Despite awareness that secondhand smoke (SHS) exacerbates asthma symptoms, more than half of US children with asthma are exposed to SHS,1 and the parent is the primary source of exposure.2,3 Explanations for failure to prevent SHS exposure in the home for children with asthma are multifaceted and not well understood, and significant underreporting of SHS exposure occurs.4 Furthermore, few health care professionals use biomarkers (ie, cotinine) as an objective measure of SHS exposure.5 There has been ...περισσότερα »
ASA must be given to classify multiple NSAID-hypersensitivity patients as selective or cross-intolerant
ASA must be given to classify multiple NSAID-hypersensitivity patients as selective or cross-intolerant:
Endotypes of Pollen Food Syndrome in Children with Seasonal Allergic Rhinoconjunctivitis: a molecular classification
Endotypes of Pollen Food Syndrome in Children with Seasonal Allergic Rhinoconjunctivitis: a molecular classification: Abstract Background Pollen food syndrome (PFS) is heterogeneous with regard to triggers, severity, natural history, comorbidities and response to treatment. Our study aims to classify different endotypes of PFS based on IgE sensitization to panallergens. Methods We examined 1271 Italian children (age 4-18y) with seasonal allergic rhinoconjunctivitis (SAR). Foods triggering PFS were acquired by questionnaire. Skin prick tests were performed with commercial pollen ext...περισσότερα »
Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity – emerging roles in obesity, intestinal inflammation and cancer
Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity – emerging roles in obesity, intestinal inflammation and cancer: Interleukin (IL)-33, a member of the IL-1 family, was originally described in 2005 as a potent initiator of type 2 immunity found during allergic inflammation and parasitic infections. IL-33 has been shown to play important and potent roles bridging innate and adaptive immunity in the regulation of tissue homeostasis, injury and repair. Recent discoveries have extended the range of functions for IL-33 beyond type 2 conditions and its role as an...περισσότερα »
L’expansion cutanée chez l’enfant
: indications et gestion des complications. Notre expérience sur 10 ans via Plastique Esthétique Publication date: Available online 19 March 2016 *Source:*Annales de Chirurgie Plastique Esthétique Author(s): M. Duclert-Bompaire, A. Sallot, H. Lardy, A. Le Touze IntroductionL’expansion cutanée est une technique de chirurgie plastique qui permet de restituer au patient une qualité et une surface cutanées optimales en cas de perte de substance à couvrir. Malgré les bons résultats obtenus, tant sur le plan fonctionnel qu’esthétique, cette technique reste pourvoyeuse de nombreuses complicat...περισσότερα »
The use of epidermal grafts to optimise outpatient wound management
A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management: ABSTRACT Current wound management through the use of a split-thickness skin graft often requires hospital admission, a period of immobility, attentive donor site wound care and pain management. This study evaluates the feasibility of using a novel epidermal graft-harvesting device (CelluTome) that allows pain-free epidermal skin grafting in the outpatient clinic setting. A prospective series of 35 patients was performed in 2 centres, involving 10 acute and 25 chronic wounds. All... περισσότερα »
Suboptimal identification of patient-specific risk factors for poor wound healing can be improved by simple interventions
Suboptimal identification of patient-specific risk factors for poor wound healing can be improved by simple interventions: Abstract Poor wound healing is an important surgical complication. At-risk wounds must be identified early and monitored appropriately. Wound surveillance is frequently inadequate, leading to increased rates of surgical site infections (SSIs). Although the literature demonstrates that risk factor identification reduces SSI rates, no studies have focused on wound management at a junior level. Our study assesses documentation rates of patient-specific risk factor... περισσότερα »
Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction
Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction: Abstract The diabetic foot ulcer (DFU) is the leading cause of lower extremity amputation worldwide and is directly associated with comorbidity, disability and mortality. Oxidative stress mechanisms have been implicated in the pathogenesis of these wounds. Intra-lesional infiltration of epidermal growth factor has emerged as a potential therapeutic alternative to allow for physiological benefit while avoiding the proteolytic environment at th... περισσότερα »
Transmaxillary Sinus Approach for Le Fort II Osteotomy
Transmaxillary Sinus Approach for Le Fort II Osteotomy: [image: image] Summary: The Le Fort II osteotomy is a relatively rare operation. The posterior wall osteotomy of the maxillary sinus (MS) is often difficult for Le Fort III. We developed the transmaxillary sinus approach (TSA) for the Le Fort II osteotomy that cuts the posterior wall of the MS directly. This report illustrates this easy-to-use procedure for the Le Fort II osteotomy in syndromic craniosynostosis. This procedure was performed in an 18-year-old patient with Apert syndrome and a 15-year-old patient with Pfeiffer s... περισσότερα »
Comparing Morbidities of Bone Graft Harvesting from the Olecranon Process and the Distal Radius
Comparing Morbidities of Bone Graft Harvesting from the Olecranon Process and the Distal Radius: Background: The aim of this study is to compare donor-site morbidities between patients who underwent bone graft harvesting from either the olecranon process (OP) or the distal radius (DR). Methods: We evaluated 44 patients who underwent bone graft harvesting from the OP (25 cases) or the DR (19 cases) for various procedures in the ipsilateral upper extremity. Follow-up averaged 14 (OP group) and 19 months (DR group). Outcome measures included visual analog scales (VAS) for graft harve...περισσότερα »
Japanese Interrogation Techniques From Prisoners Perspectives
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
This study examined responses to a self-report questionnaire on interviewing techniques administered to 291 incoming adult male prison inmates across Japan who were convicted of murder, robbery, arson, rape, forcible indecency, or kidnapping. The questionnaire focused on interrogations that led to confessions. Four interview styles (Evidence-confrontational, Relationship-focused, Undifferentiated-high, and Undifferentiated-low) were identified. For prisoners who […]
Assessing Risk for Recidivism in Individuals Convicted of Stalking Offenses: Predictive Validity of the Guidelines for Stalking Assessment and Management
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
This study examined the internal validity and predictive accuracy of the Guidelines for Stalking Assessment and Management (SAM), a structured professional judgment risk assessment tool for stalking. Interviewers rated 89 stalking offenders on the Psychopathy Checklist: Screening Version (PCL:SV) and SAM Nature (N) and Perpetrator (P) subscales. Researchers obtained stalking and violence outcomes prospectively from […]
Excluded, intimidated and harassed: LGBT physicists face discrimination
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Transgender people are the most affected. Nature News doi: 10.1038/nature.2016.19614 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S3bvP2 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Massive network of robotic ocean probes gets smart upgrade
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Initiatives aim to measure global warming’s impact on high seas and deep currents. Nature 531 421 doi: 10.1038/531421a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UBGqrK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Exploring the mechanisms of distraction from in-vehicle technology: The development of the PARRC model
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Publication date: August 2016 Source:Safety Science, Volume 87 Author(s): Katie J. Parnell, Neville A. Stanton, Katherine L. Plant Technological advances are impacting in-vehicle systems, providing more secondary tasks for drivers to engage with. The adverse impacts of this on driver safety requires further insight to determine the mechanisms involved in distraction and countermeasures to mitigate […]
Fast calcium wave inhibits excessive apoptosis during epithelial wound healing
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract Successful wound closure is mainly the result of two cellular processes: migration and proliferation. Apoptosis has also been suggested to play a role in the mechanisms of wound healing. The fast calcium wave (FCW), triggered immediately after a wound is produced, has been proposed to be involved in determining healing responses in epithelia. We […]
Uterine Prx2 restrains decidual differentiation through inhibiting lipolysis in mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract Uterine decidualization, characterized as extensive stromal cell proliferation, differentiation and polyploidization, is a crucial event for successful pregnancy and is tightly regulated by many different molecules and pathways. Prx2, an evolutionarily conserved homeobox transcription factor expressed in both embryos and adults, plays an important role during mesenchymal cell differentiation. However, it remains unclear what […]
Changes of myoid and endothelial cells in the peritubular wall during contraction of the seminiferous tubule
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 15 δευτερόλεπτα
Abstract The wall of the seminiferous tubule in rodents consists of an inner layer of myoid cells covered by an outer layer of endothelial cells. Myoid cells are a type of smooth muscle cell containing α-actin filaments arranged in two independent layers that contract when stimulated by endothelin-1. The irregular surface relief of the tubular […]
Distally based subcutaneous veins for venous insufficiency of the reverse posterior interosseous artery flap
Distally based subcutaneous veins for venous insufficiency of the reverse posterior interosseous artery flap: Background The reverse posterior interosseous artery flap (PIAF) provides soft, thin, and pliable tissue for upper extremity reconstruction without sacrificing any major arteries of the hand. The authors performed a new technique that included one extra distally based subcutaneous vein within the pedicle to diminish venous insufficiency and they aimed to present the results of reconstruction with this technique. Patients and Methods Twelve patients with a mean age of 30 year... περισσότερα »
Mandibular Advancement Splints Decreases Blood Pressure Similarly as with CPAP in Sleep Apnea
Mandibular Advancement Splints Decreases Blood Pressure Similarly as with CPAP in Sleep Apnea: Abstract The cost of obstructive sleep apnea (OSA) can be measured through the decrease in quality of life, negative impact on systemic health, mood disturbances, decline in cognition and increased medical costs. OSA, a chronic inflammatory disease, is characterized by repetitive blood oxygen desaturation, cortical micro-arousal and negative thoracic pressure on the heart. This article is protected by copyright. All rights reserved.
speech and language; +24 new citations
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *speech and language* These pubmed results were generated on 2016/03/22 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Speech via a.lsfakia on Inoreader http://ift.tt/22tHD9q via IFTTT
Minimal orthodontics of Class III patients with different facial types
Comparison of the stability after mandibular setback with via Oral and Maxillofacial Surgery Publication date: Available online 17 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): You-Sun Lee, Young-Kyun Kim, Pil-Young Yun, Brent E. Larson, Nam-Ki Lee PurposeMost studies on the surgery-first approach focused on skeletal relapse compared to conventional surgery. The objective of this study was to compare the stability of skeletal Class III patients with two different vertical facial types after mandibular setback surgery (MS) with minimal orthodontic preparation... περισσότερα »
Mucosal melanoma in the head and neck
Survival outcomes of mucosal melanoma in the head and neck: case series and review of current treatment guidelines via Oral and Maxillofacial Surgery Publication date: Available online 17 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Omar Breik, Felix Sim, Tim Wong, Alf Nastri, Tim A. Iseli, David Wiesenfeld IntroductionMucosal malignant melanoma of the head and neck (MMHN) is an aggressive and rare neoplasm with poor long-term outcomes. The aim of this study is to evaluate the outcomes from a single institution head and neck multidisciplinary team.MethodsRet...περισσότερα »
Complications with allogeneic, cancellous bone blocks
in vertical alveolar ridge augmentation: prospective clinical case study and review of the literature via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 17 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): G.F. Draenert, P.W. Kämmerer, M. Berthold, A. Neff ObjectivesVertical bone augmentation procedures in dental implantology are an indication for cancellous allogeneic bone blocks (ABB). Though, these materials may lead to adverse reactions as known well from orthopedics but rarely published...περισσότερα »
Cone-Beam Computed Tomography imaging for Adenoid Hypertrophy screening
Accuracy and Reliability of Oral Maxillofacial Radiologists when evaluating Cone-Beam Computed Tomography imaging for Adenoid Hypertrophy screening: A comparison with Nasopharyngoscopy via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 18 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Camila Pachêco-Pereira, Noura Alsufyani, Michael P. Major, Carlos Flores-Mir ObjectiveTo determine how accurate and reliable is a sample of Oral Maxillofacial Radiologists (OMFRs) in screening for adenoid hyp...περισσότερα »
Vascular Adverse Events Associated with Facial Soft Tissue Fillers
An Overview of Vascular Adverse Events Associated with Facial Soft Tissue Fillers: Recognition, prevention, and treatment via Oral and Maxillofacial Surgery Publication date: Available online 19 March 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Elie M. Ferneini, Antoine M. Ferneini Minimally invasive facial cosmetic surgery procedures have seen an exponential increase in numbers over the past decade. The most commonly performed procedures are neuromodulators and soft tissue fillers. Although soft tissue fillers have a high safety and predictability profile, these ...περισσότερα »
HPV prevalence and p16INKa overexpression in non smoking non drinking oral cavity cancer patients
HPV prevalence and p16INKa overexpression in non smoking non drinking oral cavity cancer patients: Abstract Objective Our aim was to compare HPV and p16 expression and their influence on survival and prognosis in oral cavity squamous cell cancer (OCSCC), between non smokers non drinkers (NSND) and smokers drinkers (SD). Subjects and Methods Patients with OCSCC treated with surgery from 2000 to 2010 were included in the study. Patients that did not smoke at all or smoked less then 10 pack/years, and did not drink alcohol on a daily basis were considered the NSND group. An equal numbe... περισσότερα »
The role of myofibroblasts in the development of osteoradionecrosis
in a newly established rabbit animal model via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 19 March 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Chunlin Zong, Bolei Cai, Xinxin Wen, Syed Alam, Yuanli Chen, Yuxuan Guo, Yanpu Liu, Lei Tian This study aimed to establish a proper animal model of osteoradionecrosis of jaws (ORNJ) and to observe preliminarily the characteristics of myofibroblasts, the key effector cell of fibrosis, in ORNJ. Rabbit mandibles were irradiated at three different doses based on a human ...περισσότερα »
Etiology and Pathogenesis of Oral Lichen Planus
: An Overview via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Zoya B. Kurago Oral lichen planus (OLP) is a non-infectious chronic inflammatory condition that involves the oral mucosal stratified squamous epithelium and the underlying lamina propria, which may be accompanied by skin lesions. This overview describes the current understanding of the immunopathologic mechanisms implicated in OLP.Oral lichen planus (OLP) is recognized as a no... περισσότερα »
Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?
Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?: Abstract ObjectivesAngiogenesis and neovascularisation plays a crucial role for tumorigenesis and tumor progression in head and neck squamous cell carcinoma (HNSCC). The aim of our study was to investigate the neovascularization capacity by endothelial progenitor cells (EPC) in tumor patient as a possible predictor for tumor progression and tumor stage. Materials and methodsTherefore, we investigated... περισσότερα »
The use of the tongue repositioning manoeuvre (TRM) during panoramic radiography so as to avoid the tongue shadow error
Can the tongue shadow in panoramic radiographs be avoided using the tongue repositioning manoeuvre? via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 19 March 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Robert Cordesmeyer, Wilfried Engelke, Christian Sömmer, Philipp Kauffmann ObjectiveThe purpose of this study was to evaluate the use of the tongue repositioning manoeuvre (TRM) during panoramic radiography so as to avoid the tongue shadow error.Study DesignA total of 300 panoramic radiographs ...περισσότερα »
Halitosis, an imperative constraint in measuring the outcome of the oral care in oncology patients
Halitosis, an imperative constraint in measuring the outcome of the oral care in oncology patients: Oral health perception among palliative care staff demonstrated fresh breath as effective oral care in oncology patients; “sometimes…it smells when you ‘re taking to somebody…that means this person is not …being taken care of… You know taking care of this person they are not doing their [job]…Interview I.” [1] Bad Breath or halitosis in oncology patients is an unpleasant altered breath experienced and sometimes impairs them leading to psychosocial issues, hence it’s one of the most im...περισσότερα »
Inferior alveolar nerve function after open reduction and internal fixation of mandibular fractures
Inferior alveolar nerve function after open reduction and internal fixation of mandibular fractures: Mandibular fractures are amongst the most common facial fractures and are usually treated by open reduction and internal fixation (ORIF). Inferior alveolar nerve (IAN) injuries are seen frequently in mandibular fractures as well as after ORIF of these fractures due to the exposition and the close proximity of the nerve during fracture reduction. Therefore the continuity of the IAN can be disrupted. Permanent injury to the IAN can result in diminished quality of life. This retrospectiv... περισσότερα »
Use of a dermal regeneration template and full thickness skin grafts to reconstruct exposed bone in the head and neck
Use of a dermal regeneration template and full thickness skin grafts to reconstruct exposed bone in the head and neck via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 19 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Mark Singh, D. Godden, J. Farrier, V. Ilankovan Soft tissue defects over bone are difficult to reconstruct and this is compounded when there is no periosteum. We present what is to our knowledge the first reported use of a dermal regeneration template (Integra®, Integra Life Sciences Corp, Plainsboro,... περισσότερα »
The role of myofibroblasts in the development of osteoradionecrosis
The role of myofibroblasts in the development of osteoradionecrosis in a newly established rabbit animal model: This study aimed to establish a proper animal model of osteoradionecrosis of jaws (ORNJ) and to observe preliminarily the characteristics of myofibroblasts, the key effector cell of fibrosis, in ORNJ. Rabbit mandibles were irradiated at three different doses based on a human equivalent radiation schedule, and examined by gross manifestation, single-photon emission computed tomography (SPECT), micro–computed tomography, sequential fluorochrome labeling, and histology. Immun...περισσότερα »
Volumetric modulated arc radiotherapy of the whole larynx, followed by a single affected vocal cord, for T1a glottic cancer: Dosimetric analysis of a case.
*Volumetric modulated arc radiotherapy of the whole larynx, followed by a single affected vocal cord, for T1a glottic cancer: Dosimetric analysis of a case.* Mol Clin Oncol. 2016 Mar;4(3):429-432 Authors: Yeo SG Abstract Radiation therapy (RT) and endolaryngeal surgery are standard treatments for early-stage glottic cancer. They have closely matched oncological outcomes; however, it is debatable which method is superior in terms of functional outcomes. Several dosimetric studies have demonstrated that, compared with conventional RT, intensity-modulated RT (IMRT) reduces unnecess... περισσότερα »
The postnatal ontogeny of the sexually dimorphic vocal apparatus in goitred gazelles (Gazella subgutturosa).
*The postnatal ontogeny of the sexually dimorphic vocal apparatus in goitred gazelles (Gazella subgutturosa).* J Morphol. 2016 Mar 21; Authors: Efremova KO, Frey R, Volodin IA, Fritsch G, Soldatova NV, Volodina EV Abstract This study quantitatively documents the progressive development of sexual dimorphism of the vocal organs along the ontogeny of the goitred gazelle (Gazella subgutturosa). The major, male-specific secondary sexual features, of vocal anatomy in goitred gazelle are an enlarged larynx and a marked laryngeal descent. These features appear to have evolved by sexual ...περισσότερα »
Tracheo-bronchial soft tissue and cartilage resonances in the subglottal acoustic input impedance.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Tracheo-bronchial soft tissue and cartilage resonances in the subglottal acoustic input impedance.* J Acoust Soc Am. 2015 Jun;137(6):3436-46 Authors: Lulich SM, Arsikere H Abstract This paper offers a re-evaluation of the mechanical properties of the tracheo-bronchial soft tissues and cartilage and uses a model to examine their effects on the subglottal acoustic input impedance. It is shown that the values for soft tissue elastance and cartilage viscosity typically used in models of subglottal acoustics during phonat... περισσότερα »
The source-filter theory of whistle-like calls in marmosets: Acoustic analysis and simulation of helium-modulated voices.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *The source-filter theory of whistle-like calls in marmosets: Acoustic analysis and simulation of helium-modulated voices.* J Acoust Soc Am. 2015 Jun;137(6):3068-76 Authors: Koda H, Tokuda IT, Wakita M, Ito T, Nishimura T Abstract Whistle-like high-pitched "phee" calls are often used as long-distance vocal advertisements by small-bodied marmosets and tamarins in the dense forests of South America. While the source-filter theory proposes that vibration of the vocal fold is modified independently from the resonance of t... περισσότερα »
Articulation and vocal tract acoustics at soprano subject's high fundamental frequencies.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Articulation and vocal tract acoustics at soprano subject's high fundamental frequencies.* J Acoust Soc Am. 2015 May;137(5):2586-95 Authors: Echternach M, Birkholz P, Traser L, Flügge TV, Kamberger R, Burk F, Burdumy M, Richter B Abstract The role of the vocal tract for phonation at very high soprano fundamental frequencies (F0s) is not yet understood in detail. In this investigation, two experiments were carried out with a single professional high soprano subject. First, using two dimensional (2D) dynamic real-time ... περισσότερα »
The clinical management of inoperable endometrial carcinoma.
*The clinical management of inoperable endometrial carcinoma.* Expert Rev Anticancer Ther. 2016 Mar 21; Authors: Mutch DG, Palisoul M Abstract Unresectable endometrial cancer, while rare, has a very poor prognosis, with a survival rate of 2 to 8 months. Although endometrial cancer is generally regarded as a survivable disease, the less common advanced and aggressive forms account for a large portion of endometrial cancer related deaths. Given the paucity of inoperable disease, randomized clinical data is lacking in this specific patient population. Management decisions regarding ... περισσότερα »
Recent developments in second and third line therapy of metastatic renal cell carcinoma.
*Recent developments in second and third line therapy of metastatic renal cell carcinoma.* Expert Rev Anticancer Ther. 2016 Mar 21; Authors: Giuseppa VM, Cartenì G PMID: 26999490 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Sf9GBc via IFTTT
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
*Metastatic osteosarcoma: a challenging multidisciplinary treatment.* Expert Rev Anticancer Ther. 2016 Mar 21; Authors: Meazza C, Scanagatta P Abstract Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and postoperative chemotherapy in association with the surgical removal of the tumor. About 15-20% of patients have evidence of metastases at diagnosis, mostly in the lungs. Patients with metastatic disease still have a very poor prognosis, with approximately 20-30% of long-term survivors, as compared with 65-70% of patients with localized disease. The...περισσότερα »
Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions.
*Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions.* Expert Rev Anticancer Ther. 2016 Mar 21; Authors: Myrehaug S, Sahgal A, Russo SM, Lo SS, Rosati LM, Mayr NA, Lock M, Small W, Dorth JA, Ellis RJ, Teh BS, Herman JM Abstract Despite advances in surgical, medical, and radiation therapy for pancreatic cancer, the prognosis remains poor. At this time, the only chance for long-term survival is surgical resection. More challenging is the optimal management of unresectable locally advanced pancreatic cancer, which has historically been treated...περισσότερα »
Characteristics of rumen in Naemi lamb: Morphological changes in response to altered feeding regimen.
*Characteristics of rumen in Naemi lamb: Morphological changes in response to altered feeding regimen.* Acta Histochem. 2016 Mar 16; Authors: Alhidary I, Abdelrahman MM, Alyemni AH, Khan RU, Al-Mubarak AH, Albaadani HH Abstract This study sought to chart the ontogenesis of rumen in Naemi lambs through histomorphometeric evaluation subjected to alfalfa hay in total mixed rations (TMR). A total of 40 growing healthy Naemi male lambs (28.85±1.09kg), at weaning (90±3days) was randomly distributed into four groups. One group was fed on TMR (control) only, while others were supplement...περισσότερα »
Are some people suffering as a result of increasing mass exposure of the public to ultrasound in air?
*Are some people suffering as a result of increasing mass exposure of the public to ultrasound in air?* Proc Math Phys Eng Sci. 2016 Jan;472(2185):20150624 Authors: Leighton TG Abstract New measurements indicate that the public are being exposed, without their knowledge, to airborne ultrasound. Existing guidelines are insufficient for such exposures; the vast majority refers to occupational exposure only (where workers are aware of the exposure, can be monitored and can wear protection). Existing guidelines are based on an insufficient evidence base, most of which was collected o... περισσότερα »
Autosomal dominant spinal muscular atrophy with lower extremity predominance: A recognizable phenotype of BICD2 mutations.
*Autosomal dominant spinal muscular atrophy with lower extremity predominance: A recognizable phenotype of BICD2 mutations.* Muscle Nerve. 2016 Mar 21; Authors: Rudnik-Schöneborn S, Deden F, Eggermann K, Eggermann T, Wieczorek D, Sellhaus B, Yamoah A, Goswami A, Claeys KG, Weis J, Zerres K Abstract INTRODUCTION: Heterozygous BICD2 gene mutations cause a form of autosomal dominant spinal muscular atrophy with lower extremity predominance (SMALED). METHODS: We analyzed the BICD2 gene in a selected group of 25 index patients with neurogenic muscle atrophy. RESULTS: We identified 2 new... περισσότερα »
Loss of orofacial tissue secondary to septic shock caused by Streptococcus pneumoniae
Loss of orofacial tissue secondary to septic shock caused by Streptococcus pneumoniae via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 19 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): B. Srinivasan, J. Sloane, S. Walsh Purpura fulminans is a rare complication of septic shock with a high mortality. It can result in a severe loss of skin, and often amputation of limbs. Managing the loss of tissue is a challenge that requires a multidisciplinary approach.
The Effect of Cleft Lip on Adults' Responses to Faces: Cross-Species Findings
The Effect of Cleft Lip on Adults' Responses to Faces: Cross-Species Findings: by Christine E. Parsons, Katherine S. Young, Emma Parsons, Annika Dean, Lynne Murray, Tim Goodacre, Louise Dalton, Alan Stein, Morten L. Kringelbach Cleft lip and palate is the most common of the congenital conditions affecting the face and cranial bones and is associated with a raised risk of difficulties in infant-caregiver interaction; the reasons for such difficulties are not fully understood. Here, we report two experiments designed to explore how adults respond to infant faces with and without cle... περισσότερα »
BMP4 Was Associated with Isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P)
BMP4 Was Associated with NSCL/P in an Asian Population: by Qianqian Chen, Hong Wang, Jacqueline B. Hetmanski, Tianxiao Zhang, Ingo Ruczinski, Holger Schwender, Kung Yee Liang, M. Daniele Fallin, Richard J. Redett, Gerald V. Raymond, Yah-Huei Wu Chou, Philip Kuo-Ting Chen, Vincent Yeow, Samuel S. Chong, Felicia S. H. Cheah, Ethylin Wang Jabs, Alan F. Scott, Terri H. Beaty Background The Bone Morphogenetic Protein 4 gene (*BMP4*) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a geno... περισσότερα »
Proton Magnetic Resonance Spectroscopy : All-Trans-Retinoic Acid (ATRA)–Induced Craniofacial Development
Metabolic Characterization of All-Trans-Retinoic Acid (ATRA)–Induced Craniofacial Development of Murine Embryos Using In Vivo Proton Magnetic Resonance Spectroscopy: by Feifei Qin, Zhiwei Shen, Lihong Peng, Renhua Wu, Xiao Hu, Guishan Zhang, Shijie Tang Aim To characterize the abnormal metabolic profile of all-trans-retinoic acid (ATRA)–induced craniofacial development in mouse embryos using proton magnetic resonance spectroscopy (1H-MRS). Methods Timed-pregnant mice were treated by oral gavage on the morning of embryonic gestation day 11 (E11) with all-trans-retinoic acid (AT...περισσότερα »
All-Trans-Retinoic Acid (ATRA)–Induced Craniofacial Development
Metabolic Characterization of All-Trans-Retinoic Acid (ATRA)–Induced Craniofacial Development of Murine Embryos Using In Vivo Proton Magnetic Resonance Spectroscopy: by Feifei Qin, Zhiwei Shen, Lihong Peng, Renhua Wu, Xiao Hu, Guishan Zhang, Shijie Tang Aim To characterize the abnormal metabolic profile of all-trans-retinoic acid (ATRA)–induced craniofacial development in mouse embryos using proton magnetic resonance spectroscopy (1H-MRS). Methods Timed-pregnant mice were treated by oral gavage on the morning of embryonic gestation day 11 (E11) with all-trans-retinoic acid (AT...περισσότερα »
Characterization of Subtle Brain Abnormalities in Hedgehog Pathway Antagonist-Induced Cleft Lip and Palate
Characterization of Subtle Brain Abnormalities in a Mouse Model of Hedgehog Pathway Antagonist-Induced Cleft Lip and Palate: by Robert J. Lipinski, Hunter T. Holloway, Shonagh K. O'Leary-Moore, Jacob J. Ament, Stephen J. Pecevich, Gary P. Cofer, Francois Budin, Joshua L. Everson, G. Allan Johnson, Kathleen K. Sulik Subtle behavioral and cognitive deficits have been documented in patient cohorts with orofacial clefts (OFCs). Recent neuroimaging studies argue that these traits are associated with structural brain abnormalities but have been limited to adolescent and adult populations... περισσότερα »
Ambient Air Pollution and Birth Defects
Ambient Air Pollution and Birth Defects in Brisbane, Australia: by Craig A. Hansen, Adrian G. Barnett, Bin B. Jalaludin, Geoffrey G. Morgan Background Birth defects are a major public health concern as they are the leading cause of neonatal and infant mortality. Observational studies have linked environmental pollution to adverse birth outcomes, including congenital anomalies. This study examined potential associations between ambient air pollution and congenital heart defects and cleft lip or palate among births in Brisbane, Australia (1998–2004). Methods Ambient air pollution...περισσότερα »
Association between MTHFR C677T and A1298C Polymorphisms and Nonsyndromic cleft lip with or without palate (NSCL/P)
Association between MTHFR C677T and A1298C Polymorphisms and NSCL/P Risk in Asians: A Meta-Analysis: by Mengmeng Zhao, Yangwu Ren, Li Shen, Yue Zhang, Baosen Zhou Objective Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the association, a meta-analysis was performed. Methods We searched Pubmed, MedLine and EmBase database to selected eligible studies. T... περισσότερα »
Upper Triangular Flap in Unilateral Cleft Lip Repair.
Upper Triangular Flap in Unilateral Cleft Lip Repair.: In this article, the authors describe their use of the upper triangular flap method to repair unilateral cleft lips in 250 patients with cosmetically appealing and predictable results. This method produces a straight philtral column scar that is parallel to the noncleft side and hides the surgical scars on the medial aspect of the nostril and in the lip-columellar crease. The first step is to assign the reference points along the vermilion border and the nostril sills. It is important to identify the nostril sill on the cleft no... περισσότερα »
Repair of Critical Calvarias Defects With Systemic Epimedium sagittatum Extract.
Repair of Critical Calvarias Defects With Systemic Epimedium sagittatum Extract.: It is well established in reconstructive surgery the repair of great bone defects is a difficult goal to be achieved. The aim of this study was to evaluate the influence of an extract rich in icariin on bone neoformation in critically sized defects in rat calvaria. Under continual saline irrigation, a circular bone defect was created in 40 rat calvarias with an 8-mm diameter trephine drill. Animals were randomly divided into a test group that received an Epimedium sagittatum extract (containing 5.8 mg/... περισσότερα »
Changes in Corneal Curvature After Upper Eyelid Surgery Measured by Corneal Topography.
Changes in Corneal Curvature After Upper Eyelid Surgery Measured by Corneal Topography.: Abstract Purpose: To analyze corneal curvature changes (eg, central corneal power and corneal astigmatism) after upper eyelid surgery, and to compare the effects of different upper eyelid procedures on corneal curvature. Methods: Fifty eyes of 34 patients with various degrees of dermatochalasis or ptosis underwent corneal topography before surgery, and at 6 weeks after blepharoplasty or levator resection. Patients were divided into groups according to the method of surgery. Preoperative and p... περισσότερα »
Effect of a low dose of midazolam on high blood pressure
in dental patients: a randomised, double-blind, placebo-controlled, two-centre study via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 19 March 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Yoshihisa Watanabe, Hitoshi Higuchi, Minako Ishii-Maruhama, Yuka Honda, Akiko Yabuki-Kawase, Ayaka Yamane-Hirano, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the manage... περισσότερα »
Lingual Nerve Deficits After Mandibular Bilateral Sagittal Split Osteotomy.
Meta-analysis of the Incidence of Lingual Nerve Deficits After Mandibular Bilateral Sagittal Split Osteotomy.: Introduction: Bilateral sagittal split osteotomy is a relatively common maxillofacial surgical procedure. The most commonly reported complication is neurosensory disturbances (NSD). The inferior alveolar nerve is by far the most commonly affected but sporadic reports of NSD of the lingual nerve also exist. The aim of this meta-analysis is to estimate the incidence of lingual nerve NSD following bilateral sagittal split osteotomy. Materials and Methods: A systematic search o... περισσότερα »
Clinical Features and Treatment of Distal Intracranial Aneurysms.
Clinical Features and Treatment of Distal Intracranial Aneurysms.: To analyze the clinical characteristics, therapies, and outcomes of distal intracranial aneurysms, the authors retrospectively studied the clinical and imaging data of 18 patients with distal intracranial aneurysms. There were 10 males and 8 females, aged from 11 months to 59 years (mean, 40.4 +/- 11.4 years). All patients were diagnosed by digital subtract angiography. Aneurysm locations were as follows: distal anterior cerebral artery (n = 5), distal middle cerebral artery (n = 2), distal posterior cerebral artery ... περισσότερα »
Aberrant Internal Carotid Artery: A Rare Cause of Dysphagia.
Aberrant Internal Carotid Artery: A Rare Cause of Dysphagia.:
Endoscopic Intradural Subtemporal Keyhole Kawase Approach to the Petroclival and Ventrolateral Brainstem Regions.
Endoscopic Intradural Subtemporal Keyhole Kawase Approach to the Petroclival and Ventrolateral Brainstem Regions.: Objective: To study the endoscope anatomy of the petroclival and ventrolateral brainstem regions via the intradural subtemporal keyhole Kawase approach and discuss the feasibility and indications of this approach to the regions. Materials and Methods: Craniotomy procedures performed via the intradural subtemporal keyhole Kawase approach were simulated on 16 sides of 8 adult cadaveric heads fixed by formalin, and the related anatomical structures were observed through th...περισσότερα »
A Simple Technique to Avoid Restenosis for Dacryocystorhinostomy.
A Simple Technique to Avoid Restenosis for Dacryocystorhinostomy.: The most common reason for failure in dacryocystorhinostomy has been proven to be the granuloma or membranous obstruction of scar tissue formation on lacrimal opening in the nasal cavity during the healing process. In this article, the authors suggest an easy maneuver to avoid the risk of scarring and collapsing of the knot in bony window by using a piece of an aspiration catheter. Using this easy maneuver, the authors can manage to reduce the risk of scarring and stenosis, and when the authors take out the tubes aft... περισσότερα »
Dermoid Cyst Causing Dysphagia and Dyspnea.
Giant Dermoid Cyst Causing Dysphagia and Dyspnea.: Dermoid cysts are benign lesions seen in young adults. The second most common localization is the floor of the mouth. They are usually asymptomatic over years but can be symptomatic due to secondary changes or the size. Herein, we report a case of 19-year-old woman who applied to emergency service with dyspnea, dysphagia and enlarging of a mass in the submental region. The patient cannot be entubated because of the mass pushing the tongue base backward closing the laryngeal view. Elective tracheostomy was performed for providing air...περισσότερα »
Eosinophilic Granuloma of the Mandible
A Case of Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control?.: Eosinophilic granuloma is the most benign and common form of the Langerhans cell histiocytosis, a rare proliferative disease that can affect single or multiple organs. In the quite common head and neck manifestation these lesions can be confused in the beginning, with other bone diseases such as odontogenic cysts, periodontal disease, or malignancies. Treatment varies depending on the size, number, localization of the lesions, and patient's general conditions. The au...περισσότερα »
Frontal-Temporal Lobe Arachnoid Cyst Presenting as an Weariness Migraine.
Huge Frontal-Temporal Lobe Arachnoid Cyst Presenting as an Weariness Migraine.: To the authors' knowledge, most of intracranial arachnoid cyst located in middle cranial fossa and lateral fissure cistern. So, huge frontal-temporal lobe arachnoid cyst is rare. Symptoms of arachnoid cyst may be atypical, including headache, nausea, vomiting, epilepsy, poor memory, and so on. Of course, migraine related to weariness is a rare benign headache disorder. The authors reported a patient presenting with weariness migraine associated with large frontal-temporal lobe arachnoid cyst. (C) 2016 b...περισσότερα »
Versatility of Distraction Osteogenesis for the Craniofacial Skeleton.
Versatility of Distraction Osteogenesis for the Craniofacial Skeleton.: Abstract Malformations of the craniofacial skeleton are common. Restoration of anatomic shape, size, and position has been traditionally accomplished using autologous bone grafting to fill gaps created by surgery and segmental movement. The authors present their practice using distraction in many different ages and settings over 20 years. A retrospective review was performed of all craniofacial patients treated using distraction osteogenesis for mandible, midface, and calvarium. The authors identified 205 pa... περισσότερα »
Intranasal Extramucosal Access for Lateral Osteotomy in Open Rhinoplasty.
Intranasal Extramucosal Access: A New Access for Lateral Osteotomy in Open Rhinoplasty.: Background and Objective: Different accesses have been used to perform lateral osteotomies in rhinoplasty. All of them have some disadvantages. The aim of this paper was to report a new access to overcome drawbacks of the other techniques in lateral osteotomy during open rhinoplasty. Methods: An anatomical study was designed to search possibility of intranasal extramucosal access (open sky access) for the lateral osteotomy in open rhinoplasty. It was performed directly on the lateral wall of pi...περισσότερα »
Influence of prior hyperventilation duration on respiratory chemosensitivity and cerebrovascular reactivity during modified hyperoxic rebreathing
The “Duffin” modified hyperoxic rebreathing test allows investigators to characterize and quantify the ventilatory and cerebrovascular responses to CO2 across a large physiological range, allowing quantification of basal ventilation and the ventilatory recruitment threshold (VRT). Although the standard protocol includes 5-min of prior hyperventilation to clear body CO2 stores, there is no experimental evidence that a full 5-min is required. We hypothesized that there would be no within-individual differences in the cardiorespiratory or cerebrovascular responses to rebreathing with ... περισσότερα »
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].: Authors: Martínez-Cabriales SA, Gómez-Flores M, Ocampo-Candiani J Abstract Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening conditions associated with significant morbidity and mortality. They are considered to be part of a spectrum of cutaneous drug reactions, differing only by their extent of skin detachment due to keratinocyte apoptosis. Drugs are assumed as the main cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in...περισσότερα »
Speech timing and linguistic rhythm: on the acoustic bases of rhythm typologies.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Speech timing and linguistic rhythm: on the acoustic bases of rhythm typologies.* J Acoust Soc Am. 2015 May;137(5):2834 Authors: Rathcke TV, Smith RH Abstract Research into linguistic rhythm has been dominated by the idea that languages can be classified according to rhythmic templates, amenable to assessment by acoustic measures of vowel and consonant durations. This study tested predictions of two proposals explaining the bases of rhythmic typologies: the Rhythm Class Hypothesis which assumes that the templates ar...περισσότερα »
Expectations and speech intelligibility.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Expectations and speech intelligibility.* J Acoust Soc Am. 2015 May;137(5):2823-33 Authors: Babel M, Russell J Abstract Socio-indexical cues and paralinguistic information are often beneficial to speech processing as this information assists listeners in parsing the speech stream. Associations that particular populations speak in a certain speech style can, however, make it such that socio-indexical cues have a cost. In this study, native speakers of Canadian English who identify as Chinese Canadian and White Canadia... περισσότερα »
Effect of the division between early and late reflections on intelligibility of ideal binary-masked speech.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Effect of the division between early and late reflections on intelligibility of ideal binary-masked speech.* J Acoust Soc Am. 2015 May;137(5):2801-10 Authors: Li J, Xia R, Fang Q, Li A, Pan J, Yan Y Abstract The ideal binary mask (IBM) that was originally defined in anechoic conditions has been found to yield substantial improvements in speech intelligibility in noise. The IBM has recently been extended to reverberant conditions where the direct sound and early reflections of target speech are regarded as the desired... περισσότερα »
AIDS and Behavior, Vol. 20, Issue 4 - New Issue Alert
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/22/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *AIDS and Behavior*. Volume 20 Number 4 is now available online. In this issue Original Paper Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings Jessica F. Magidson, Xin Li, Matthew J. Mimiaga, Ayana T. Moore, Kriengkrai Srithanaviboonchai, Ruth K... περισσότερα »
African Mole-Rats: So Much More Than Just the Naked Mole-Rat
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
An intriguing tale of colonial life, surprising phylogenetic relationships, and giant protruding incisors…
Molecular diagnosis and precision medicine in allergy management
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Authors: Riccio, Anna Maria / De Ferrari, Laura / Chiappori, Alessandra / Ledda, Sabina / Passalacqua, Giovanni / Melioli, Giovanni / Canonica, Giorgio Walter from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UjL3qk via IFTTT
Hybrid minigene splicing assay verified the pathogenicity of a novel splice site variant in the dystrophin gene of a Chinese patient with typical Duchenne muscular dystrophy phenotype
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Authors: Wang, Zhihong / Lin, Yanhong / Qiu, Liping / Zheng, Dezhu / Yan, Aizhen / Zeng, Jian / Lan, Fenghua from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R6FndF via IFTTT
Effects of methylphenidate and MDMA on appraisal of erotic stimuli and intimate relationships
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Methylphenidate mainly enhances dopamine neurotransmission whereas 3,4-methylenedioxymethamphetamine (MDMA, «ecstasy») mainly enhances serotonin neurotransmission. However, both drugs also induce a weaker increase of cerebral noradrenaline exerting sympathomimetic properties. Dopaminergic psychostimulants are reported to increase sexual drive, while serotonergic drugs typically impair sexual arousal and functions. Additionally, serotonin has also been shown to modulate cognitive perception of […]
Differential effects of MDMA and methylphenidate on social cognition
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Social cognition is important in everyday-life social interactions. The social cognitive effects of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) and methylphenidate (both used for neuroenhancement and as party drugs) are largely unknown. We investigated the acute effects of MDMA (75 mg), methylphenidate (40 mg) and placebo using the Facial Emotion Recognition Task, Multifaceted Empathy Test, Movie for the […]
In vitro characterization of psychoactive substances at rat, mouse, and human trace amine-associated receptor 1
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Trace amine-associated receptor 1 (TAAR1) has been implicated in the behavioral effects of amphetamine-type stimulant drugs in rodents. TAAR1 has also been suggested as a target for novel medications to treat psychostimulant addiction. We previously reported that binding affinities at TAAR1 can differ between structural analogs of psychostimulants, and species differences have been observed. In […]
IJMS, Vol. 17, Pages 427: Arsenite Regulates Prolongation of Glycan Residues of Membrane Glycoprotein: A Pivotal Study via Wax Physisorption Kinetics and FTIR Imaging
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Arsenic exposure results in several human cancers, including those of the skin, lung, and bladder. As skin cancers are the most common form, epidermal keratinocytes (KC) are the main target of arsenic exposure. The mechanisms by which arsenic induces carcinogenesis remains unclear, but aberrant cell proliferation and dysregulated energy homeostasis play a significant role. Protein […]
IJMS, Vol. 17, Pages 424: Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Gastric cancer is the third leading cause of cancer mortality worldwide. Unfortunately, most gastric cancer cases are diagnosed in an advanced, non-curable stage and with a limited response to chemotherapy. Drug resistance is one of the most important causes of therapy failure in gastric cancer patients. Although the mechanisms of drug resistance have been broadly […]
IJMS, Vol. 17, Pages 432: Proteomics-Based Analysis of Protein Complexes in Pluripotent Stem Cells and Cancer Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
A protein complex consists of two or more proteins that are linked together through protein–protein interactions. The proteins show stable/transient and direct/indirect interactions within the protein complex or between the protein complexes. Protein complexes are involved in regulation of most of the cellular processes and molecular functions. The delineation of protein complexes is important to […]
IJMS, Vol. 17, Pages 431: Molecular Insight into Gut Microbiota and Rheumatoid Arthritis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed […]
Making Sense of China’s Drop in Coal Use
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 45 δευτερόλεπτα
It’s happened for the second year in a row, but reduced coal consumption doesn’t necessarily translate into reduced emissions
Angiogenesis inhibitor; +19 new citations
19 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *Angiogenesis inhibitor* These pubmed results were generated on 2016/03/22 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/25iffWC via IFTTT
The relationship between senile hearing loss and vestibular activity.
*The relationship between senile hearing loss and vestibular activity.* Braz J Otorhinolaryngol. 2016 Feb 28; Authors: Kurtaran H, Acar B, Ocak E, Mirici E Abstract INTRODUCTION: A considerable high number of SNHL patients also suffer from dizziness and related vestibular symptoms. OBJECTIVE: To evaluate the association of vestibular dysfunction and sensorineural hearing loss (SNHL) in adult patients. METHODS: Prospective, double-blinded, controlled studies composed by 63 adult patients without any vestibular symptoms or diagnosed vestibular diseases. Audiological status was measur...περισσότερα »
Feeding methods for children with cleft lip and/or palate: a systematic review.
*Feeding methods for children with cleft lip and/or palate: a systematic review.* Braz J Otorhinolaryngol. 2016 Mar 2; Authors: Duarte GA, Ramos RB, Cardoso MC Abstract INTRODUCTION: Feeding difficulties in children with cleft lip and palate (CLP) are frequent and appear at birth due to impairment of sucking and swallowing functions. The use of appropriate feeding methods for the different types of cleft and the period of the child's life is of utmost importance for their full development. OBJECTIVE: Review studies comparing feeding methods for children with CLP, pre- and postope...περισσότερα »
Unusual coexisting thyroglossal duct cyst and second branchial cleft fistula in an adult.
*Unusual coexisting thyroglossal duct cyst and second branchial cleft fistula in an adult.* Braz J Otorhinolaryngol. 2016 Feb 28; Authors: Lee DH, Yoon TM, Lee JK, Lim SC PMID: 26997573 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/25ifctZ via IFTTT
Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia.
*Alvocidib (flavopiridol) for the treatment of chronic lymphocytic leukemia.* Expert Opin Investig Drugs. 2016 Mar 21; Authors: Wiernik PH Abstract INTRODUCTION: Alvocidib, which has orphan drug designation in chronic lymphocytic leukemia (CLL) from the FDA and the EMA, is a plant-derived semisynthetic flavone that acts as a cyclin-dependent kinase inhibitor. It induces apoptosis in CLL cells in vitro and was introduced into clinical trials in CLL as an intravenous infusion in 1997, which proved disappointing. Since the drug avidly binds to plasma proteins, higher serum concentr... περισσότερα »
Sorafenib for the treatment of multiple myeloma.
*Sorafenib for the treatment of multiple myeloma.* Expert Opin Investig Drugs. 2016 Mar 21; Authors: Gentile M, Martino M, Recchia AG, Vigna E, Morabito L, Morabito F Abstract INTRODUCTION: Sorafenib is an orally available compound that acts predominantly by targeting the Ras/Raf/MEK/ERK pathway and by inhibiting the vascular endothelial growth factor (VEGF). Since the Ras/Raf/MEK/ERK pathway is implicated in the proliferation of multiple myeloma (MM) cells and VEGF in bone marrow neovascularization, sorafenib is a drug offering the potential for targeting two important pathogenet... περισσότερα »
Investigational drugs in phase I and phase II clincial trials for the treatment of hospital-acquired pneumonia.
*Investigational drugs in phase I and phase II clincial trials for the treatment of hospital-acquired pneumonia.* Expert Opin Investig Drugs. 2016 Mar 21; Authors: Falcó V, Burgos J, Papiol E, Ferrer R, Almirante B Abstract INTRODUCTION: Hospital acquired pneumonia (HAP) is one of the main infections acquired by patients during a stay in hospital. The main issue when dealing with patients with HAP and ventilator associated pneumonia (VAP) is the increasing role of multi-drug resistant organisms (MDROs). Areas covered: In this review the authors summarize the actual situation of M... περισσότερα »
Estimates of decision weights and internal noise in the masked discrimination of vowels by young and elderly adults.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Estimates of decision weights and internal noise in the masked discrimination of vowels by young and elderly adults.* J Acoust Soc Am. 2015 Jun;137(6):EL403-7 Authors: Gilbertson L, Lutfi RA, Lee J Abstract Gilbertson and Lutfi [(2014). Hear. Res. 317, 9-14] report that older adults perform similarly to younger adults on a masked vowel discrimination task when the fundamental frequency (F0) of target and masker vowel differ but that the older adults perform more poorly when the F0 is the same. This paper presents an ... περισσότερα »
Volumetric modulated arc radiotherapy of the whole larynx, followed by a single affected vocal cord, for T1a glottic cancer: Dosimetric analysis of a case.
*Volumetric modulated arc radiotherapy of the whole larynx, followed by a single affected vocal cord, for T1a glottic cancer: Dosimetric analysis of a case.* Mol Clin Oncol. 2016 Mar;4(3):429-432 Authors: Yeo SG Abstract Radiation therapy (RT) and endolaryngeal surgery are standard treatments for early-stage glottic cancer. They have closely matched oncological outcomes; however, it is debatable which method is superior in terms of functional outcomes. Several dosimetric studies have demonstrated that, compared with conventional RT, intensity-modulated RT (IMRT) reduces unnecess... περισσότερα »
The postnatal ontogeny of the sexually dimorphic vocal apparatus in goitred gazelles (Gazella subgutturosa).
*The postnatal ontogeny of the sexually dimorphic vocal apparatus in goitred gazelles (Gazella subgutturosa).* J Morphol. 2016 Mar 21; Authors: Efremova KO, Frey R, Volodin IA, Fritsch G, Soldatova NV, Volodina EV Abstract This study quantitatively documents the progressive development of sexual dimorphism of the vocal organs along the ontogeny of the goitred gazelle (Gazella subgutturosa). The major, male-specific secondary sexual features, of vocal anatomy in goitred gazelle are an enlarged larynx and a marked laryngeal descent. These features appear to have evolved by sexual ...περισσότερα »
Tracheo-bronchial soft tissue and cartilage resonances in the subglottal acoustic input impedance.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Tracheo-bronchial soft tissue and cartilage resonances in the subglottal acoustic input impedance.* J Acoust Soc Am. 2015 Jun;137(6):3436-46 Authors: Lulich SM, Arsikere H Abstract This paper offers a re-evaluation of the mechanical properties of the tracheo-bronchial soft tissues and cartilage and uses a model to examine their effects on the subglottal acoustic input impedance. It is shown that the values for soft tissue elastance and cartilage viscosity typically used in models of subglottal acoustics during phonat... περισσότερα »
The source-filter theory of whistle-like calls in marmosets: Acoustic analysis and simulation of helium-modulated voices.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *The source-filter theory of whistle-like calls in marmosets: Acoustic analysis and simulation of helium-modulated voices.* J Acoust Soc Am. 2015 Jun;137(6):3068-76 Authors: Koda H, Tokuda IT, Wakita M, Ito T, Nishimura T Abstract Whistle-like high-pitched "phee" calls are often used as long-distance vocal advertisements by small-bodied marmosets and tamarins in the dense forests of South America. While the source-filter theory proposes that vibration of the vocal fold is modified independently from the resonance of t... περισσότερα »
Articulation and vocal tract acoustics at soprano subject's high fundamental frequencies.
[image: http:--link.aip.org-jhtml-linkto.gif] Related Articles *Articulation and vocal tract acoustics at soprano subject's high fundamental frequencies.* J Acoust Soc Am. 2015 May;137(5):2586-95 Authors: Echternach M, Birkholz P, Traser L, Flügge TV, Kamberger R, Burk F, Burdumy M, Richter B Abstract The role of the vocal tract for phonation at very high soprano fundamental frequencies (F0s) is not yet understood in detail. In this investigation, two experiments were carried out with a single professional high soprano subject. First, using two dimensional (2D) dynamic real-time ... περισσότερα »
Small intestinal injury in mice infected with respiratory influenza A virus: evidence for virus induced gastroenteritis.
[image: http:--production.springer.de-OnlineReso] Related Articles *Small intestinal injury in mice infected with respiratory influenza A virus: evidence for virus induced gastroenteritis.* Biotechnol Lett. 2015 Aug;37(8):1585-92 Authors: Zhang S, Wei T, Tianv H, Cheng J, Xiao J, Wang M, Hu Y Abstract OBJECTIVES: Influenza in humans is often accompanied by gastroenteritis-like symptoms such as diarrhea and abdominal pain nausea, but the underlying mechanism remains unclear. RESULTS: Mice infected with three subtypes of respiratory influenza A virus (IAV), particularly H5N1 and H7N... περισσότερα »
Investigation of nanostructural changes following acute injury using atomic force microscopy in rabbit vocal folds.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Investigation of nanostructural changes following acute injury using atomic force microscopy in rabbit vocal folds.* Microsc Res Tech. 2015 Jul;78(7):569-76 Authors: Lee YC, Kim HJ, Kim KS, Choi S, Kim SW, Park HK, Eun YG Abstract There continues to be a paucity of data regarding the nanostructural changes of vocal fold (VF) collagen after injury. The aim of this study is to investigate the nanostructural and morphological changes in the rabbit VF lamina propria following acute injury using atomic force microscopy... περισσότερα »
Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum.
[image: http:--http://ift.tt/1XLQsFQ] Related Articles *Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum.* Biosci Biotechnol Biochem. 2015;79(6):992-6 Authors: Hino S, Ito A, Kondo T, Morita T Abstract We histologically examined the effects of elemental diet (ED) on the goblet cell profile in the rat small intestine. The sulfomucin goblet cells were predominant throughout the small intestine in the control group, while sialomucin goblet cells were manifest in the duodenum and jejunum in the ED group. Next, we investigated the pos... περισσότερα »
macrophage; +48 new citations
48 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *macrophage* These pubmed results were generated on 2016/03/22 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/25ifaSV via IFTTT
Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses.
*Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses.* Food Funct. 2016 Mar 21; Authors: Zhang J, Chen JM, Wang XX, Xia YM, Cui SW, Li J, Ding ZY Abstract Polysaccharides from Ganoderma lucidum (GLPs) have been taken as effective supplements by both healthy people and cancer patients for many years. However, this short survey indicates that instead of inhibiting cancer cell growth, both submerge-cultured intracellular GLP and fruiting body GLP can stimulate the growth of human carcinoma cell lines lackin...περισσότερα »
Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia.
[image: http:--production.springer.de-OnlineReso] Related Articles *Paternal intake of folate and vitamins B6 and B12 before conception and risk of childhood acute lymphoblastic leukemia.* Cancer Causes Control. 2014 Dec;25(12):1615-25 Authors: Bailey HD, Miller M, Greenop KR, Bower C, Attia J, Marshall GM, Armstrong BK, Milne E Abstract PURPOSE: We investigated whether paternal dietary intake of folate before conception is associated with the risk of childhood acute lymphoblastic leukemia (ALL) in a nationwide case-control study. METHODS: Data on dietary folate intake during the ... περισσότερα »
Comparison of Fixed versus Calculated Activity of Radioiodine for the Treatment of Graves Disease in Adults.
*Comparison of Fixed versus Calculated Activity of Radioiodine for the Treatment of Graves Disease in Adults.* Endocrinol Metab (Seoul). 2016 Mar;31(1):168-73 Authors: Canto AU, Dominguez PN, Jimeno CA, Obaldo JM, Ogbac RV Abstract BACKGROUND: Radioactive iodine as a treatment modality has been shown in several studies to be a safe and effective therapy for Graves disease. However, there is still no uniformity regarding optimal dosing method. The aim of this study is to compare the efficacy of calculated and fixed dosing of radioiodine for the treatment of Graves disease. METHODS:...περισσότερα »
Secretory diarrhoea: mechanisms and emerging therapies.
[image: http:--http://ift.tt/1OOTDZp] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Secretory diarrhoea: mechanisms and emerging therapies.* Nat Rev Gastroenterol Hepatol. 2015 Aug;12(8):446-57 Authors: Thiagarajah JR, Donowitz M, Verkman AS Abstract Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic disorders. Fluid secretion across the intestinal epithelium in secretory diarrhoeas involves multiple ion and solute transporters, as well as activa... περισσότερα »
AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway.
*AURKA promotes cell migration and invasion of head and neck squamous cell carcinoma through regulation of the AURKA/Akt/FAK signaling pathway.* Oncol Lett. 2016 Mar;11(3):1889-1894 Authors: Wu J, Yang L, Shan Y, Cai C, Wang S, Zhang H Abstract The present study aimed to investigate the mechanism by which Aurora kinase A (AURKA) promotes cell migration and invasion in head and neck squamous cell carcinoma (HNSCC). Transwell assays were performed to investigate the cell migration and invasion abilities of AURKA, whilst western blotting was used to analyze the protein expression in ... περισσότερα »
Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.
*Initial evidence for Sec62 as a prognostic marker in advanced head and neck squamous cell carcinoma.* Oncol Lett. 2016 Mar;11(3):1661-1670 Authors: Wemmert S, Lindner Y, Linxweiler J, Wagenpfeil S, Bohle R, Niewald M, Schick B Abstract Head and neck squamous cell carcinoma (HNSCC) is a malignancy with an increasing incidence. To aid with the selection of the most appropriate therapy, biomarkers have become a specific research focus. Sec62 is involved in endoplasmic reticulum stress tolerance and cell migration, and has been identified as a novel prognostic marker for non-small c...περισσότερα »
upper respiratory tract infection; +49 new citations
49 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *upper respiratory tract infection* These pubmed results were generated on 2016/03/22 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1Zny2vw via IFTTT
Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions.
*Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions.* Expert Rev Anticancer Ther. 2016 Mar 21; Authors: Myrehaug S, Sahgal A, Russo SM, Lo SS, Rosati LM, Mayr NA, Lock M, Small W, Dorth JA, Ellis RJ, Teh BS, Herman JM Abstract Despite advances in surgical, medical, and radiation therapy for pancreatic cancer, the prognosis remains poor. At this time, the only chance for long-term survival is surgical resection. More challenging is the optimal management of unresectable locally advanced pancreatic cancer, which has historically been treated...περισσότερα »
The basal ganglia: from motor commands to the control of vigor
Publication date: Available online 21 March 2016 Source:Current Opinion in Neurobiology Author(s): Joshua T Dudman, John W Krakauer Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over… Continue reading The basal ganglia: from motor commands to the control of vigor
A new method for making treatment decisions for incapacitated patients: what do patients think about the use of a patient preference predictor?
Background Surrogates frequently are unable to predict which treatment their charges would want and also can experience significant distress as a result of making treatment decisions. A new method, the patient preference predictor (PPP), has been proposed as a possible way to supplement the process of shared decision-making to address these two concerns. The PPP… Continue reading A new method for making treatment decisions for incapacitated patients: what do patients think about the use of a patient preference predictor?
In the balance: evolving trends in the satisfaction of junior doctors inside and outside work
In this issue, Surman and colleagues from the UK Medical Careers Research Group present longitudinal data on how job satisfaction and work–life balance have changed for junior doctors over a 16-year period (1996–2012).1 Half of the graduates seem satisfied with their jobs at 1 and 5 years after graduation. Disappointingly, the more recent data show… Continue reading In the balance: evolving trends in the satisfaction of junior doctors inside and outside work
New Targeted Treatment for Ankylosing Spondylitis
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1RwvMCq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WFfXrh via IFTTT
The Mediterranean refugee crisis: ethics, international law and migrant health
The Mediterranean refugee crisis: ethics, international law and migrant health Europe is experiencing levels of forced migration not seen since the Second World War. Its sources lie in the fragile, strife-torn states of the Middle East and Africa: four million people have fled Syria since the conflict began; 12 million of those remaining require humanitarian… Continue reading The Mediterranean refugee crisis: ethics, international law and migrant health
Role of UTS2 gene in the genetic susceptibility to atrial fibrillation in the Chinese population
Objective Atrial fibrosis plays a key role in the inducibility and persistence of atrial fibrillation. Urotensin II (U-II/UTS2) induces cardiac fibrosis by increasing fibroblast collagen synthesis and increased U-II plasma levels have been reported in patients with atrial fibrosis. Our objective was therefore to evaluate the possible role of the UTS2 gene polymorphisms Thr21Met and… Continue reading Role of UTS2 gene in the genetic susceptibility to atrial fibrillation in the Chinese population
Correction
Curtis B, Vehmas S. A Moorean argument for the full moral status of those with profound intellectual disability. J Med Ethics 2016;42:41–5. A section of text is missing from the article at page 43, the correct text should state: In a common interpretation of what Moore is up to here, first championed by William Lycan… Continue reading Correction
Cardiac manifestations in alcoholic liver disease
Alcoholic liver disease is the most prevalent cause of progressive liver disease in Europe. Alcoholic cirrhosis occurs in 8%–20% of cases of alcoholic liver disease. It has significant influence on cardiovascular system and haemodynamics through increased heart rate, cardiac output, decreased systemic vascular resistance, arterial pressure and plasma volume expansion. Cirrhotic cardiomyopathy is characterised by… Continue reading Cardiac manifestations in alcoholic liver disease
The Moorean argument for the full moral status of those with profound intellectual disability: a rejoinder to Roberts
In a recent paper we argued that a Moorean strategy can be employed to justify our continuing to believe the following proposition, even in the presence of philosophical views that entail it is false, without any philosophical argument against those views, and without any positive philosophical argument in its favour: H>A: Humans have an equal… Continue reading The Moorean argument for the full moral status of those with profound intellectual disability: a rejoinder to Roberts
Having hands and moral status: a reply to Curtis and Vehmas
Curtis and Vehmas apply the form of Moore’s ‘Proof of an External World’ to justify continuing to believe that all and only humans have full moral status in the absence of a plausible account of why. I note that the strategy is better suited for the sceptical problems Moore applies it to and suggest that… Continue reading Having hands and moral status: a reply to Curtis and Vehmas
Comparison of Outcome Between Surgical and Conservative Management of Symptomatic Spinal Cord Cavernous Malformations
[image: image]BACKGROUND: Intramedullary cavernous malformations (CMs) are rare lesions with unclear natural history. OBJECTIVE: To compare the functional outcomes of spinal CMs managed surgically and conservatively. METHODS: We performed a retrospective study of patients diagnosed with intramedullary CMs seen at our institution from 2006 to 2013. Functional outcomes of patients were assessed by treatment modality with the Modified McCormick Scale and Karnofsky Performance Status. RESULTS: We identified a total of 85 study-eligible patients; 51 (60.0%) were male. Mean age of patient... περισσότερα »
The basal ganglia: from motor commands to the control of vigor
[image: S09594388.gif] Publication date: Available online 21 March 2016 *Source:*Current Opinion in Neurobiology Author(s): Joshua T Dudman, John W Krakauer Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has indicated that a subcortical circuit, the basal ganglia, is a critical determinant of movement vigor in rodents a... περισσότερα »
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