Primary Occipital Encephalocele in an Elderly Patient.
The encephalocele is a condition characterized by the protrusion of the intracranial contents through a bone defect of the skull. The authors report a clinical case of an 80-year-old woman with primary occipital encephalocele on the right side and that was affected by trauma and presented liquor fistula and infection. Tomographic sections were obtained by injection intravenous of contrast. The images showed bone thickness thinning on the right occipital region and solution of continuity (encephalocele) with regular contours, reduction in brain volume, and hypodensity of the perivent... περισσότερα »
Management of Limited Vertical Bone Height in the Posterior Mandible: Short Dental Implants Versus Nerve Lateralization With Standard Length Implants.
Inferior alveolar nerve lateralization (IANL) and short dental implants (SDI) are 2 viable implant-based treatment approaches in the presence of atrophied posterior mandible. Despite the risks of dysfunction, infection, and pathologic fractures in IANL, it becomes possible to place standard implants. The purpose of this study was to compare SDI and IANL approaches from clinical and radiographic aspects. Fifteen subjects having unilateral atrophic mandibles were allocated to SDI and IANL treatment groups. Following surgical procedures, early postoperative complications, implant survi... περισσότερα »
Versatility of Distraction Osteogenesis for the Craniofacial Skeleton.
Malformations of the craniofacial skeleton are common. Restoration of anatomic shape, size, and position has been traditionally accomplished using autologous bone grafting to fill gaps created by surgery and segmental movement. The authors present their practice using distraction in many different ages and settings over 20 years. A retrospective review was performed of all craniofacial patients treated using distraction osteogenesis for mandible, midface, and calvarium. The authors identified 205 patient. Mandible: 112 patients were treated at an average age of 3.4 years. 18.8% of p...περισσότερα »
Stress Analysis of Axial and Tilted Implants in Full-arch Fixed Dentures Under Different Abutment Conditions.
The aim of this study was to evaluate the stress distribution on full-arch prostheses, considering axial implants and tilted implants with or without abutments. Two photoelastic models were made, being that in 1 model the implants were inserted perpendicular, whereas in the other model 2 implants were inserted perpendicular and 2 implants were inserted with tilting 30[degrees] to the distal area. The prosthetic situations were evaluated: A-axial implants and nonsegmented full-arch prosthesis; B-axial implants and segmented full-arch prosthesis; C-tilted distal implants and nonsegmen... περισσότερα »
Intranasal Extramucosal Access: A New Access for Lateral Osteotomy in Open Rhinoplasty.
Background and Objective: Different accesses have been used to perform lateral osteotomies in rhinoplasty. All of them have some disadvantages. The aim of this paper was to report a new access to overcome drawbacks of the other techniques in lateral osteotomy during open rhinoplasty. Methods: An anatomical study was designed to search possibility of intranasal extramucosal access (open sky access) for the lateral osteotomy in open rhinoplasty. It was performed directly on the lateral wall of piriform aperture, and then possible advantages of this technique were investigated. Five fi... περισσότερα »
Huge Frontal-Temporal Lobe Arachnoid Cyst Presenting as an Weariness Migraine.
To the authors' knowledge, most of intracranial arachnoid cyst located in middle cranial fossa and lateral fissure cistern. So, huge frontal-temporal lobe arachnoid cyst is rare. Symptoms of arachnoid cyst may be atypical, including headache, nausea, vomiting, epilepsy, poor memory, and so on. Of course, migraine related to weariness is a rare benign headache disorder. The authors reported a patient presenting with weariness migraine associated with large frontal-temporal lobe arachnoid cyst. (C) 2016 by Mutaz B. Habal, MD. from OroFacial Medicine via ola Kala on Inoreader http://if... περισσότερα »
A Case of Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control?.
Eosinophilic granuloma is the most benign and common form of the Langerhans cell histiocytosis, a rare proliferative disease that can affect single or multiple organs. In the quite common head and neck manifestation these lesions can be confused in the beginning, with other bone diseases such as odontogenic cysts, periodontal disease, or malignancies. Treatment varies depending on the size, number, localization of the lesions, and patient's general conditions. The authors describe here a patient of a single lesion of eosinophilic granuloma localized in the posterior mandible region ...περισσότερα »
Review of "Assessing Awareness and Implementation of a Recommendation for Surgical Innovation Committees: A Survey of Academic Institutions" by McNair LA, Biffl WL in Ann Surg 262:941-948, 2015.
No abstract available from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1XJ9NXf via IFTTT
Review of "Getting Clearer About Surgical Innovation" by Hutchison K, Rogers W, Eyers A, Lotz M in Ann Surg 262: 949-954, 2015.
No abstract available from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/25hFsoh via IFTTT
Giant Dermoid Cyst Causing Dysphagia and Dyspnea.
Dermoid cysts are benign lesions seen in young adults. The second most common localization is the floor of the mouth. They are usually asymptomatic over years but can be symptomatic due to secondary changes or the size. Herein, we report a case of 19-year-old woman who applied to emergency service with dyspnea, dysphagia and enlarging of a mass in the submental region. The patient cannot be entubated because of the mass pushing the tongue base backward closing the laryngeal view. Elective tracheostomy was performed for providing airflow during the operation. After the operation a cy...περισσότερα »
A Simple Technique to Avoid Restenosis for Dacryocystorhinostomy.
The most common reason for failure in dacryocystorhinostomy has been proven to be the granuloma or membranous obstruction of scar tissue formation on lacrimal opening in the nasal cavity during the healing process. In this article, the authors suggest an easy maneuver to avoid the risk of scarring and collapsing of the knot in bony window by using a piece of an aspiration catheter. Using this easy maneuver, the authors can manage to reduce the risk of scarring and stenosis, and when the authors take out the tubes after 2 months, removing the silicone tube was easier with our techniqu...περισσότερα »
Endoscopic Intradural Subtemporal Keyhole Kawase Approach to the Petroclival and Ventrolateral Brainstem Regions.
Objective: To study the endoscope anatomy of the petroclival and ventrolateral brainstem regions via the intradural subtemporal keyhole Kawase approach and discuss the feasibility and indications of this approach to the regions. Materials and Methods: Craniotomy procedures performed via the intradural subtemporal keyhole Kawase approach were simulated on 16 sides of 8 adult cadaveric heads fixed by formalin, and the related anatomical structures were observed through the 0-degree endoscope or alternatively 30-degree one. Measurements of the shortest distances from the highest point ...περισσότερα »
Aberrant Internal Carotid Artery: A Rare Cause of Dysphagia.
No abstract available from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/25hFpsx via IFTTT
Microbiota-derived metabolites modulate tissue homeostasis: relevance to the oral cavity?
Microbiota-derived metabolites modulate tissue homeostasis: relevance to the oral cavity?: The human intestinal tract is inhabited by an estimated 100 trillion of microorganisms, collectively known as the microbiota. These microorganisms consist mainly of bacteria, but also archaea, fungi, viruses, and protozoa. Early in life, the human host and its microbiota establish mutualistic relationships. For example, the microbiota contributes to host physiology by digesting dietary fibers and synthesizing vitamins, while the host provides nutrients that are necessary for bacterial growth.... περισσότερα »
Perforator anatomy of the radial forearm free flap versus the ulnar forearm free flap for head and neck reconstruction
Perforator anatomy of the radial forearm free flap versus the ulnar forearm free flap for head and neck reconstruction: Abstract The aim of this study was to investigate the vascular anatomy of the distal forearm in order to optimize the choice between the radial forearm free flap and the ulnar forearm free flap and to select the best site to harvest the flap. The radial and ulnar arteries of seven fresh cadavers were injected with epoxy resin (Araldite) and the perforating arteries were dissected. The number of clinically relevant perforators from the radial and ulnar arteries ... περισσότερα »
EUS in obstructive esophageal cancer : Endoscopic ultrasound (EUS) is considered the most sensitive modality for local staging of esophageal cancer (ECA)
EUS in obstructive esophageal cancer: Abstract Background Endoscopic ultrasound (EUS) is considered the most sensitive modality for local staging of esophageal cancer (ECA) and current guidelines recommend EUS in all patients with non-metastatic disease. Our aim was to identify a subset of patients with stenotic, non-metastatic ECA who will not benefit from staging EUS. Methods This multi-center study evaluated consecutive patients with newly diagnosed non-metastatic ECA referred for local staging by EUS. All patients had endoscopic evaluation of malignant strictures with 9.8/9.9 mm...περισσότερα »
Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta-analysis update
Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta-analysis update: Summary Early detection of esophageal squamous cell carcinoma (ESCC) is urgently needed to reduce the high morbidity and mortality of disease. Circulating microRNAs (miRNAs) are promising molecular biomarkers for ESCC prediction. We performed a comprehensive meta-analysis to systematically evaluate the diagnostic accuracy of circulating miRNAs in diagnosis of ESCC patients. Eligible studies were identified and assessed for quality employing multiple search stra... περισσότερα »
Efficacy of docetaxel, cisplatin, and 5-fluorouracil chemotherapy for superficial esophageal squamous cell carcinoma
Efficacy of docetaxel, cisplatin, and 5-fluorouracil chemotherapy for superficial esophageal squamous cell carcinoma: Summary The anticancer efficacy of docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy has been reported to be better than that of conventional regimens for advanced or relapsed esophageal squamous cell carcinoma (ESCC), and may become a standard therapy for this disease. Because it is extremely rare for chemotherapy to be administered as treatment for early cancer alone, the efficacy of DCF for superficial ESCC remains unknown. However, from a clinical onco...περισσότερα »
Chemotherapy-induced nausea and vomiting is less controlled
Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: a prospective registration study by the CINV Study Group of Japan: Summary Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemoth... περισσότερα »
Provision of an on-call service for regional anaesthesia.
No abstract available from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LD6vnG via IFTTT
IgA-Nephritis: Therapie im Wandel
Supportiv vor immunsuppressiv Seit über 50 Jahren werden Glomerulonephritiden entzündungshemmend und immunsuppressiv behandelt. Wesentliche Eckpfeiler der supportiven Therapie sind eine konsequente Blutdrucksenkung und eine Proteinuriebehandlung. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LD6twa via IFTTT
Introducing Hyperthermic Intraperitoneal Chemotherapy into Gynecological Oncology Practice – Feasibility and Safety Considerations: Single-Center Experience
Oncol Res Treat from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WEIfCc via IFTTT
Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy
Summary Minimally invasive thoracoscopic esophagectomy has potential advantages in minimizing the impairment of respiratory function and reducing surgical stress. However, thoracoscopic esophagectomy occasionally results in anesthesia-induced hypothermia, particularly in cases involving artificial pneumothorax with CO2. Thermogenesis induced by amino acid administration has been reported during anesthesia. Here, we tested the efficacy of amino acid treatment… Continue reading Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postopera... περισσότερα »
Simultaneous esophagectomy and off-pump coronary artery bypass grafting: a practicable approach with good survival
Summary Surgery continues to be the mainstay of esophageal cancer treatment. However, it is a big challenge for the surgical treatment of patients with both esophageal cancer and coronary artery disease (CAD). We reported, here, the first case series of esophageal cancer patients treated with simultaneous esophagectomy and off-pump coronary artery bypass grafting (CABG). From… Continue reading Simultaneous esophagectomy and off-pump coronary artery bypass grafting: a practicable approach with good survival
A bridging stent to surgery in patients with esophageal and gastroesophageal junction cancer has a dramatic negative impact on patient survival
Summary This study aimed to assess the impact of esophageal stenting on postoperative complications and survival in patients with obstructing esophageal and gastroesophageal junction (GEJ) cancer. All patients treated without neoadjuvant therapy that had an R0-resection performed for esophageal and GEJ cancer between January 2003 and December 2010 were identified from a prospectively maintained database.… Continue reading A bridging stent to surgery in patients with esophageal and gastroesophageal junction cancer has a dramatic negative impact on patient survival
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus
Summary Background and Aims: There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. Methods: This is a cross-sectional study conducted at a County teaching hospital. Patients with esophageal papilloma… Continue reading Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus
Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohort study
Summary 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) has been investigated as a tool for monitoring response to neoadjuvant chemo- and chemoradiotherapy (CT and CRT, respectively) and as a predictor for survival in patients with esophageal cancer. In contrast to patients who undergo neoadjuvant CT, it is not known whether patients who are clinically identified as responders… Continue reading Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohor... περισσότερα »
Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
Summary The aim of this study was to evaluate the worldwide trends in surgical techniques for esophageal cancer surgery by comparing it to our survey from 2007. In addition, new questions were added for gastroesophageal junction (GEJ) cancer. An international survey on surgery of esophageal and GEJ cancer was performed among surgical members of the… Continue reading Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: a prospective registration study by the CINV Study Group of Japan
Summary Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemotherapy (MEC)… Continue reading Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: a prospective registration study by th... περισσότερα »
A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
BACKGROUND: Improved pain control after cesarean delivery remains a challenging objective. Poorly treated acute pain following delivery is associated with an increased risk of chronic pain and depression. This study was conducted to determine whether the addition of systemic acetaminophen and an increased dose of intrathecal morphine would further reduce acute pain. The primary outcome […]
The Effects of Ketamine on Cognitive Function in Elderly Patients Undergoing Ophthalmic Surgery: A Pilot Study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
BACKGROUND: Acute postoperative cognitive dysfunction is characterized by neurocognitive dysfunction and confusion. In this study, we compared the cognitive status of a geriatric population undergoing ophthalmic surgery, as assessed by the Short Portable Mental Status Questionnaire (SPMSQ) before and after ketamine administration. METHODS: Eighty patients were enrolled and randomly assigned in a double-blind study to […]
Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
BACKGROUND: Patient memories of the operating room (OR) may serve as the informational basis for assessing satisfaction with individual anesthesiologists. Furthermore, the provision of clinically important information may assume that perioperative memories are retained. Studies assessing the extent of perioperative amnesia and factors associated with perioperative amnesia are sparse. Therefore, we assessed patient amnesia of […]
Primary Occipital Encephalocele in an Elderly Patient.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
The encephalocele is a condition characterized by the protrusion of the intracranial contents through a bone defect of the skull. The authors report a clinical case of an 80-year-old woman with primary occipital encephalocele on the right side and that was affected by trauma and presented liquor fistula and infection. Tomographic sections were obtained by […]
Management of Limited Vertical Bone Height in the Posterior Mandible: Short Dental Implants Versus Nerve Lateralization With Standard Length Implants.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Inferior alveolar nerve lateralization (IANL) and short dental implants (SDI) are 2 viable implant-based treatment approaches in the presence of atrophied posterior mandible. Despite the risks of dysfunction, infection, and pathologic fractures in IANL, it becomes possible to place standard implants. The purpose of this study was to compare SDI and IANL approaches from clinical […]
Versatility of Distraction Osteogenesis for the Craniofacial Skeleton.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Malformations of the craniofacial skeleton are common. Restoration of anatomic shape, size, and position has been traditionally accomplished using autologous bone grafting to fill gaps created by surgery and segmental movement. The authors present their practice using distraction in many different ages and settings over 20 years. A retrospective review was performed of all craniofacial […]
Stress Analysis of Axial and Tilted Implants in Full-arch Fixed Dentures Under Different Abutment Conditions.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
The aim of this study was to evaluate the stress distribution on full-arch prostheses, considering axial implants and tilted implants with or without abutments. Two photoelastic models were made, being that in 1 model the implants were inserted perpendicular, whereas in the other model 2 implants were inserted perpendicular and 2 implants were inserted with […]
Intranasal Extramucosal Access: A New Access for Lateral Osteotomy in Open Rhinoplasty.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Background and Objective: Different accesses have been used to perform lateral osteotomies in rhinoplasty. All of them have some disadvantages. The aim of this paper was to report a new access to overcome drawbacks of the other techniques in lateral osteotomy during open rhinoplasty. Methods: An anatomical study was designed to search possibility of intranasal […]
Huge Frontal-Temporal Lobe Arachnoid Cyst Presenting as an Weariness Migraine.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
To the authors’ knowledge, most of intracranial arachnoid cyst located in middle cranial fossa and lateral fissure cistern. So, huge frontal-temporal lobe arachnoid cyst is rare. Symptoms of arachnoid cyst may be atypical, including headache, nausea, vomiting, epilepsy, poor memory, and so on. Of course, migraine related to weariness is a rare benign headache disorder. […]
A Case of Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control?.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Eosinophilic granuloma is the most benign and common form of the Langerhans cell histiocytosis, a rare proliferative disease that can affect single or multiple organs. In the quite common head and neck manifestation these lesions can be confused in the beginning, with other bone diseases such as odontogenic cysts, periodontal disease, or malignancies. Treatment varies […]
NK/T cell lymphoma, nasal type with sinonasal mass and palatal ulcer
: a clinical case report and review of treatment.: Authors: Kanitsap N, Warnnissorn N Abstract Extranodal Nasal NK/T cell lymphoma, relatively uncommon type of non-Hodgkin's lymphoma, is highly aggressive disease with poor outcomes. Early stage disease may response to radiotherapy alone. However the treatments are usually chemotherapy and radiotherapy combination and late stage disease may not response to any available therapy. We reported a 45-year-old woman with extranodal nasal type NK/T cell lymphoma. The patient presented with chronic nasal stuffiness and mucous bloody discha...περισσότερα »
Tuberculosis of nose and palate with vanishing uvula.
[image: http:--www.ijmm.org-images-linkout.gif] Authors: Baruah B, Goyal A, Shunyu NB, Lynrah ZA, Raphael V Abstract During the past two decades, tuberculosis - both pulmonary and extrapulmonary - has re-emerged as a major health problem worldwide. Nasal tuberculosis - either primary or secondary to pulmonary tuberculosis or facial lupus - is rare, but it should be considered in the differential diagnosis of nasal granulomas. We describe a case of tuberculosis in an adult male who presented with palatal perforation with vanishing uvula and arch deformity of the palate. The diagnos... περισσότερα »
Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohort study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Summary 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) has been investigated as a tool for monitoring response to neoadjuvant chemo- and chemoradiotherapy (CT and CRT, respectively) and as a predictor for survival in patients with esophageal cancer. In contrast to patients who undergo neoadjuvant CT, it is not known whether patients who are clinically identified as responders […]
Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Summary The aim of this study was to evaluate the worldwide trends in surgical techniques for esophageal cancer surgery by comparing it to our survey from 2007. In addition, new questions were added for gastroesophageal junction (GEJ) cancer. An international survey on surgery of esophageal and GEJ cancer was performed among surgical members of the […]
Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: a prospective registration study by the CINV Study Group of Japan
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Summary Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemotherapy (MEC) […]
Efficacy of docetaxel, cisplatin, and 5-fluorouracil chemotherapy for superficial esophageal squamous cell carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Summary The anticancer efficacy of docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy has been reported to be better than that of conventional regimens for advanced or relapsed esophageal squamous cell carcinoma (ESCC), and may become a standard therapy for this disease. Because it is extremely rare for chemotherapy to be administered as treatment for early cancer […]
Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta-analysis update
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Summary Early detection of esophageal squamous cell carcinoma (ESCC) is urgently needed to reduce the high morbidity and mortality of disease. Circulating microRNAs (miRNAs) are promising molecular biomarkers for ESCC prediction. We performed a comprehensive meta-analysis to systematically evaluate the diagnostic accuracy of circulating miRNAs in diagnosis of ESCC patients. Eligible studies were identified and […]
Gadolinium: A German follow-up
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
A detailed article about gadolinium-based contrast agents from the Maverinck… Read more on AuntMinnieEurope.com Related Reading: Gadolinium: Will anybody learn from the debacle? The calamity of medical and radiological publications The expensive dilemma: Tablets versus textbooks Max Factor — for the beauty of your curriculum vitae MR fingerprinting returns — and hopefully disappears again from […]
Learn from NSF crisis to avoid ‘gadolinium phobia’
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
When the nephrogenic systemic fibrosis (NSF) crisis broke out, very effective… Read more on AuntMinnieEurope.com Related Reading: Danger of ‘gadolinium phobia’ looms in Europe Gadolinium: Will anybody learn from the debacle? Risks of gadolinium contrast: Where are we now? ESUR updates guidelines to prevent NSF Trial shows no NSF from gadolinium, even in dialysis patients […]
Variability in Motor and Language Recovery during the Acute Stroke Period
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Background: Most stroke recovery occurs by 90 days after onset, with proportional recovery models showing an achievement of about 70% of the maximal remaining recovery. Little is known about recovery during the acute stroke period. Moreover, data are described for groups, not for individuals. In this observational cohort study, we describe for the first time […]
Mapping phase diagrams of supported lipid bilayers by atomic force microscopy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Abstract In this work, we present the method followed to construct a pseudophase diagram of two phospholipids: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol). Two different techniques, DSC and AFM, have been used based in the determination of the onset (Tonset) and completion (Toffset) temperatures of the gel-to-liquid crystalline phases (LβLα), the first from the endotherms from liposomes and […]
Epidemiology and genetic susceptibility of malignant melanoma in North Sardinia, Italy.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
The aim of this report was to study the descriptive and genetic epidemiology of malignant melanoma in North Sardinia, Italy, in the period 1992-2011. Epidemiological data were obtained from the local tumor registry, which is part of the Italian Association for Tumor Registries. Among patients included in the North Sardinia tumor registry, 316 patients first […]
Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohort study
Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohort study: Summary *18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) has been investigated as a tool for monitoring response to neoadjuvant chemo- and chemoradiotherapy (CT and CRT, respectively) and as a predictor for survival in patients with esophageal cancer. In contrast to patients who undergo neoadjuvant CT, it is not known whether patients who are clinically identified as responders after n... περισσότερα »
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus: Summary *Background and Aims:* There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. *Methods:* This is a cross-sectional study conducted at a County teaching hospital. Patients with esophageal papilloma between January 2000 and December 2013 were identified. Patients with...περισσότερα »
Simultaneous esophagectomy and off-pump coronary artery bypass grafting: a practicable approach with good survival
Simultaneous esophagectomy and off-pump coronary artery bypass grafting: a practicable approach with good survival: Summary Surgery continues to be the mainstay of esophageal cancer treatment. However, it is a big challenge for the surgical treatment of patients with both esophageal cancer and coronary artery disease (CAD). We reported, here, the first case series of esophageal cancer patients treated with simultaneous esophagectomy and off-pump coronary artery bypass grafting (CABG). From August 2010 to August 2012, 2154 esophageal or esophageal gastric junction (EGJ) cancer patie...περισσότερα »
Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy
Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy: Summary Minimally invasive thoracoscopic esophagectomy has potential advantages in minimizing the impairment of respiratory function and reducing surgical stress. However, thoracoscopic esophagectomy occasionally results in anesthesia-induced hypothermia, particularly in cases involving artificial pneumothorax with CO2. Thermogenesis induced by amino acid administration has been reported during anesthesia. Here,... περισσότερα »
Fluorinated Methacrylamide Chitosan Hydrogels Enhance Collagen Synthesis
in Wound Healing through Increased Oxygen Availability via Acta Biomaterialia Publication date: Available online 18 March 2016 *Source:*Acta Biomaterialia Author(s): Pritam S. Patil, Natalie Fountas-Davis, He Huang, M. Michelle Evancho-Chapman, Judith A. Fulton, Leah P. Shriver, Nic D. Leipzig In this study, methacrylamide chitosan modified with perfluorocarbon chains (MACF) is used as the base material to construct hydrogel dressings for treating dermal wounds. MACF hydrogels saturated with oxygen (+ O2) are examined for their ability to deliver and sustain oxygen, degrade in a biolo... περισσότερα »
Midwives’ oral health recommendations for pregnant women, infants and young children
: results of a nationwide survey in Germany: Abstract BackgroundStudies suggest that poor oral health during pregnancy can lead to perinatal complications, such as low birth weight and preterm delivery as well as poor oral health in children. Aim of this study was to assess the German midwives knowledge about oral health and preventive recommendations for pregnant women, infants and young children. MethodsThe nationwide online-survey was conducted with use of a self-developed, pretested and validated standardized questionnaire. The German association of midwives (Deutscher Heba...περισσότερα »
RGD and BMP-2 mimetic peptide crosstalk enhances osteogenic commitment
of human bone marrow stem cells via Acta Biomaterialia Publication date: Available online 18 March 2016 *Source:*Acta Biomaterialia Author(s): I. Bilem, P. Chevallier, L. Plawinski, E.D. Sone, M.C. Durrieu, G. Laroche Human bone marrow mesenchymal stem cells (hBMSCs) commitment and differentiation are dictated by bioactive molecules sequestered within their Extra Cellular Matrix (ECM). One common approach to mimic the physiological environment is to functionalize biomaterial surfaces with ECM-derived peptides able to recruit stem cells and trigger their linage-specific differentiatio... περισσότερα »
Structural analysis of the tongue and hyoid apparatus
in a woodpecker via Acta Biomaterialia Publication date: Available online 18 March 2016 *Source:*Acta Biomaterialia Author(s): Jae-Young Jung, Steven E. Naleway, Nicholas A. Yaraghi, Steven Herrera, Vincent R. Sherman, Eric A. Bushong, Mark H. Ellisman, David Kisailus, Joanna McKittrick Woodpeckers avoid brain injury while they peck at trees up to 20 Hz with speeds up to 7 m/s, undergoing decelerations up to 1200 g. Along with the head, beak and neck, the hyoid apparatus (tongue bone and associated soft tissues) is subjected to these high impact forces. The shape of the hyoid apparat... περισσότερα »
Methamphetamine Users Have Increased ...
Methamphetamine Users Have Increased Dental Disease: A Propensity Score Analysis: Methamphetamine (MA) users are assumed to have a high burden of tooth decay. Less clear is how the distribution and severity of dental caries in MA users differ from the general population. Using a covariate-balancing propensity score strategy, we investigated the differential effects of MA use on dental caries by comparing the patterns of decayed, missing, and filled teeth in a community sample of 571 MA users with a subset of 2,755 demographically similar control individuals selected from a National... περισσότερα »
Integration-Free Reprogramming of Lamina Propria Progenitor Cells
Integration-Free Reprogramming of Lamina Propria Progenitor Cells: Producing induced pluripotent stem cells (iPSCs) from human tissue for use in personalized medicine strategies or therapeutic testing is at the forefront of medicine. Therefore, identifying a source of cells to reprogram that is easily accessible via a simple noninvasive procedure is of great clinical importance. Reprogramming these cells to iPSCs through nonintegrating methods for genetic manipulation is paramount for regenerative purposes. Here, we demonstrate reprogramming of oral mucosal lamina propria progenito... περισσότερα »
Ampicillin, amoxicillin–clavulanate, and ciprofloxacin.The antibiotic of choice determined by antibiogram in maxillary sinus elevation surgery: a clinical study
The antibiotic of choice determined by antibiogram in maxillary sinus elevation surgery: a clinical study: [image: cover.gif?v=1&s=87bf4a525ec3ddfbe594c784] Abstract Objectives This study set out to make antibiograms of positive bacteria cultures in samples collected when performing maxillary sinus elevations to determine a specific and effective antibiotic in each case. Material and methods A total of 174 patients (90 women and 84 men) with a mean age of 55.92 years underwent 227 sinus elevations. As the membrane was lifted, a sample was collected from the maxillary sinus floor ... περισσότερα »
Comparison of growth & function of endothelial progenitor cells cultured on deproteinized bovine bone modified with covalently bound fibronectin and bound vascular endothelial growth factor
Comparison of growth & function of endothelial progenitor cells cultured on deproteinized bovine bone modified with covalently bound fibronectin and bound vascular endothelial growth factor: [image: cover.gif?v=1&s=87bf4a525ec3ddfbe594c784] Abstract Objectives The objective of this study was to assess and compare the growth and function of Endothelial Progenitor Cells (EPCs) cultured on covalently bonded Vascular Endothelial Growth Factor (VEGF) and covalently bonded Fibronectin (FN) coating on deproteinized bovine bone (DBB) (test samples), compared to non-modified DBB blocks (... περισσότερα »
Non-ionizing real-time ultrasonography in oral surgery
Non-ionizing real-time ultrasonography in implant and oral surgery: A feasibility study: [image: cover.gif?v=1&s=87bf4a525ec3ddfbe594c784] Abstract Purpose Ultrasound imaging has potential to complement radiographic imaging modalities in implant and oral surgery given that it is non-ionizing and provides instantaneous images of anatomical structures. For application in oral and dental imaging, its qualities are dependent on its ability to accurately capture these complex structures. Therefore, the aim of this feasibility study was to investigate ultrasound to image soft tissue, ... περισσότερα »
Anti-erosive and nano-hydroxyapatite-containing toothpastes
Caries-preventive effect of anti-erosive and nano-hydroxyapatite-containing toothpastes in vitro: Abstract ObjectivesThe aim of the study was to investigate the caries-preventive effect of newly developed fluoride and fluoride-free toothpastes specially designed for erosion prevention. The hypothesis was that these products might also show superior caries-inhibiting effect than regular fluoride toothpastes, since they were designed for stronger erosive acid challenges. Materials and methodsEnamel specimens were obtained from bovine teeth and pre-demineralized (pH = 4.95/21 days... περισσότερα »
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus
Summary *Background and Aims:* There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. *Methods:* This is a cross-sectional study conducted at a County teaching hospital. Patients with esophageal papilloma between January 2000 and December 2013 were identified. Patients with sufficient specimens were tested for the HPV virus. *Results:* Sixty patients with esophageal papilloma lesions were identi... περισσότερα »
Prediction of disease-free survival using relative change in FDG-uptake early during neoadjuvant chemoradiotherapy for potentially curable esophageal cancer: A prospective cohort study
Summary *18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) has been investigated as a tool for monitoring response to neoadjuvant chemo- and chemoradiotherapy (CT and CRT, respectively) and as a predictor for survival in patients with esophageal cancer. In contrast to patients who undergo neoadjuvant CT, it is not known whether patients who are clinically identified as responders after neoadjuvant CRT show better disease-free survival (DFS) than patients identified as nonresponders. The aim of the study was to determine the predictive value of FDG-uptake measured prior ... περισσότερα »
Worldwide trends in surgical techniques in the treatment of esophageal and gastroesophageal junction cancer
Summary The aim of this study was to evaluate the worldwide trends in surgical techniques for esophageal cancer surgery by comparing it to our survey from 2007. In addition, new questions were added for gastroesophageal junction (GEJ) cancer. An international survey on surgery of esophageal and GEJ cancer was performed among surgical members of the International Society for Diseases of the Esophagus, the World Organization for Specialized Studies on Disease of the Esophagus, the International Gastric Cancer Association. Also, surgeons from personal networks were contacted. The par...περισσότερα »
Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: a prospective registration study by the CINV Study Group of Japan
Summary Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC). The patients recorded their CINV incidence and severity daily for 7 days after receiving chemotherapy, using visual analog scal...περισσότερα »
Efficacy of docetaxel, cisplatin, and 5-fluorouracil chemotherapy for superficial esophageal squamous cell carcinoma
Summary The anticancer efficacy of docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy has been reported to be better than that of conventional regimens for advanced or relapsed esophageal squamous cell carcinoma (ESCC), and may become a standard therapy for this disease. Because it is extremely rare for chemotherapy to be administered as treatment for early cancer alone, the efficacy of DCF for superficial ESCC remains unknown. However, from a clinical oncological standpoint, it is important to investigate the anticancer efficacy of chemotherapy for early cancer, which ma... περισσότερα »
Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta-analysis update
Summary Early detection of esophageal squamous cell carcinoma (ESCC) is urgently needed to reduce the high morbidity and mortality of disease. Circulating microRNAs (miRNAs) are promising molecular biomarkers for ESCC prediction. We performed a comprehensive meta-analysis to systematically evaluate the diagnostic accuracy of circulating miRNAs in diagnosis of ESCC patients. Eligible studies were identified and assessed for quality employing multiple search strategies. Summary estimates for sensitivity, specificity, and other measures of accuracy of miRNAs in the diagnosis of ESCC w...περισσότερα »
Significance of endothelial progenitor cells (EPC) for tumorigenesis of HNSCC
: possible marker of tumor progression and neovascularization?: Abstract ObjectivesAngiogenesis and neovascularisation plays a crucial role for tumorigenesis and tumor progression in head and neck squamous cell carcinoma (HNSCC). The aim of our study was to investigate the neovascularization capacity by endothelial progenitor cells (EPC) in tumor patient as a possible predictor for tumor progression and tumor stage. Materials and methodsTherefore, we investigated the cell number and biologic activity by cell migration and colony-forming ability of EPC. Cells were isolated from ... περισσότερα »
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress
Longitudinal Multilevel Modeling of Facial Pain, Muscle Tension, and Stress: The role of masticatory muscle activation on pain in temporomandibular muscle and joint disorders (TMJD) is controversial. This single-group, prospective panel study examined the relationships among masticatory muscle tension, emotional distress, and TMJD pain in a sample of 7,023 observations obtained from 171 individuals using longitudinal multilevel modeling. Three main hypotheses were tested. The first posited that emotional distress and muscle tension directly influenced pain (hypothesis 1a: Distress... περισσότερα »
Dislocated Tongue Muscle Attachment and Cleft Palate Formation
Dislocated Tongue Muscle Attachment and Cleft Palate Formation: In Pierre Robin sequence, a retracted tongue due to micrognathia is thought to physically obstruct palatal shelf elevation and thereby cause cleft palate. However, micrognathia is not always associated with palatal clefting. Here, by using the *Bmp7*-null mouse model presenting with cleft palate and severe micrognathia, we provide the first causative mechanism linking the two. In wild-type embryos, the genioglossus muscle, which mediates tongue protrusion, originates from the rostral process of Meckel’s cartilage and l... περισσότερα »
{gamma}-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma
{gamma}-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma: Dysregulation of -synuclein (SNCG) has been reported in many cancers; however, its role in cancer development is still controversial. Here, we examined the potential involvement of DNA methylation in regulating SNCG and its role in oral squamous cell carcinoma (OSCC). We used 8 OSCC cell lines to investigate SNCG methylation and expression. SNCG methylation was examination by methylation-specific polymerase chain reaction and bisulfate sequencing. Cells showing a high degree of SNCG methylation were ... περισσότερα »
Probiotic Compared with Standard Milk
Probiotic Compared with Standard Milk for High-caries Children: A Cluster Randomized Trial: The aim of this study was to compare milk supplemented with probiotic lactobacilli with standard milk for the increment of caries in preschool children after 10 mo of intervention. The study was a triple-blind, placebo-controlled randomized trial. Participants were children aged 2 and 3 y (*n* = 261) attending 16 nursery schools in a metropolitan region in Chile. Nursery schools were randomly assigned to 2 parallel groups: children in the intervention group were given 150 mL of milk suppleme... περισσότερα »
Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases
Innate Immunity and Saliva in Candida albicans-mediated Oral Diseases: The oral cavity is a unique niche where *Candida albicans* infections occur in immunocompetent as well as immunosuppressed individuals. Here we critically review the significance of human innate immune response in preventing oral candidiasis. One important line of defense against oropharyngeal candidiasis is the oral microbiota that prevents infection by competing for space and nutrients as well as by secreting antagonistic molecules and triggering local inflammatory responses. *C. albicans* is able to induce mu...περισσότερα »
MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation
MALT1 Inhibition of Oral Carcinoma Cell Invasion and ERK/MAPK Activation: The expression of mucosa-associated lymphoid tissue 1 (MALT1) that activates nuclear factor (NF)–B in lymphocyte lineages is rapidly inactivated in oral carcinoma cells at the invasive front and the patients with worst prognosis. However, its mechanism to accelerate carcinoma progression remains unknown, and this study was carried out to examine the role in invasion. HSC2 oral carcinoma cells stably expressing wild-type MALT1 (wtMALT1) reduced the invasion of basement membrane matrices and collagen gels, and ... περισσότερα »
Natural-Origin Polymers in Hard and Soft Tissue Engineering
Dental Applications of Natural-Origin Polymers in Hard and Soft Tissue Engineering: Abstract Clinical advances in the treatment of dentoalveolar defects continue to evolve with the introduction of new innovations in regenerative medicine and tissue bioengineering. Recent developments in tissue engineering are aimed at safely and effectively regenerating a damaged or necrotic area by replenishing its cells and increasing surrounding gene expression. Various techniques have successfully given rise to porous scaffolds being used by clinicians to treat the defect and initiate the repai... περισσότερα »
Directed Acyclic Graphs for Oral Disease Research
Directed Acyclic Graphs for Oral Disease Research: Directed acyclic graphs (DAGs) are nonparametric graphical tools used to depict causal relations in the epidemiologic assessment of exposure-outcome associations. Although their use in dental research was first advocated in 2002, DAGs have yet to be widely adopted in this field. DAGs help identify threats to causal inference such as confounders, bias due to subject selection, and inappropriate handling of missing data. DAGs can also inform the data analysis strategy based on relations among variables depicted on it. This article us... περισσότερα »
Relating Hearing Aid Use to Social and Emotional Loneliness in Older Adults
Relating Hearing Aid Use to Social and Emotional Loneliness in Older Adults: Purpose Hearing loss is a risk factor for social isolation and loneliness. We investigated the buffering effects of hearing aid use on perceived social and emotional loneliness. Method Forty older adults participated. Prior to and following the hearing aid fitting, participants completed the De Jong Gierveld Loneliness Scale (De Jong Gierveld & Kamphuis, 1985); a change in feelings of loneliness following hearing aid use was the outcome indicator. Results There was a significant decline in perceptions o... περισσότερα »
The Effect of Stimulus Intensity and Carrier Frequency on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach
The Effect of Stimulus Intensity and Carrier Frequency on Auditory Middle- and Long-Latency Evoked Potentials Using a Steady-State-Response Approach: Purpose The purpose of this study was to measure magnitude changes of auditory steady-state responses (ASSRs) and respective transient middle- and long-latency responses as a function of stimulus intensity and carrier frequency. The literature lacks clear consensus, including relationship to loudness. Method A cohort of 48 adults with normal hearing was examined from a companion study (Tlumak, Durrant, & Delgado, 2015) on effects of ... περισσότερα »
Understanding frequency-compressed Mandarin sentences: Role of vowels
Understanding frequency-compressed Mandarin sentences: Role of vowels: [image: cm_sbs_024_plain.png] Frequency compression (FC) is an effective alternative to conventional amplification for patients with severe-to-profound middle- and high-frequency hearing loss and with some residual low frequency hearing. The present work investigated the underlying factors accounting for the intelligibility of FC-processed speech. Eighteen normal-hearing participants listened to FC-processed Mandarin sentences, and testing conditions included two compression strategies (i.e., linear and nonline... περισσότερα »
Quantification of the effects of audible rattle and source type on the human response to environmental vibration
Quantification of the effects of audible rattle and source type on the human response to environmental vibration: The present research quantifies the influence of source type and the presence of audible vibration-induced rattle on annoyance caused by vibration in residential environments. The sources of vibration considered are railway and the construction of a light rail system. Data were measured in the United Kingdom using a socio-vibration survey (N = 1281). These data are analyzed using ordinal logit models to produce exposure-response relationships describing community annoya... περισσότερα »
The import of within-listener variability to understanding the precedence effect
The import of within-listener variability to understanding the precedence effect: [image: cm_sbs_024_plain.png] The purpose of this study was to gather behavioral data concerning the precedence effect as manifested by the localization-dominance of the leading elements of compound stimuli. This investigation was motivated by recent findings of Shackleton and Palmer [(2006). J. Assoc. Res. Otolaryngol. 7, 425–442], who measured the electro-physiological responses of single units in the inferior colliculus of the guinea pig. The neural data from Shackleton and Palmer indicated that p... περισσότερα »
Tinnitus Relief
From Japan 2014: Tinnitus is the medical condition of ringing in the ears. Although millions of people, including Beethoven, have suffered from this condition, medical science has not found a cure. Medications and treatments are available that provide some relief, but the current best hope is tinnitus relief from Japan 2014 *Causes of Tinnitus* Causes of tinnitus include the following: - Excessive Exposure to Loud Sounds - Blockages in the Ear - Aspirin and Some Antibiotics - Some Underlying Diseases - Reconnections Occurring in the Brain While some underlying dise... περισσότερα »
HAX-1 deficiency: Recurrent gingivitis, stomatitis, and skin and soft tissue abscesses. Developmental retardation and epilepsy
HAX-1 deficiency: Characteristics of five cases including an asymptomatic patient.: Authors: Aydogmus C, Cipe F, Tas M, Akinel A, Öner Ö, Keskindemirci G, Bornaun H, Kutluk G, Hocaoglu AB Abstract BACKGROUND: Mutations in the HAX-1 gene cause an autosomal recessive form of severe congenital neutropenia (SCN), which particularly manifests with recurrent skin, lung and deep tissue infections from the first few months of life. OBJECTIVE: We retrospectively evaluated the clinical and laboratory findings of the patients diagnosed with SCN carrying HAX1 gene mutations. METHODS: A total...περισσότερα »
Perforation in submucous cleft palate due to thermal injury.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Authors: Hwang K, Kim YS Abstract I report a patient with perforation in the submucous cleft palate (SMCP) due to hot food burn. A 27-year-old woman developed a hole in her velum after a burn due to ingestion of hot food. On examination, the velum showed an SMCP with a perforation on the midline notching at the posterior edge of the hard palate. The mucosal brim of the perforation was excised, and the hole was closed at the time of repair of SMCP with V-Y push-back method. In this case, we can see that the perforation can occur by ... περισσότερα »
Long-Term Survival, Quality of Life, and Quality-Adjusted Survival in Critically Ill Patients With Cancer.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Objectives: To assess the long-term survival, health-related quality of life, and quality-adjusted life years of cancer patients admitted to ICUs. Design: Prospective cohort. Setting: Two cancer specialized ICUs in Brazil. Patients: A total of 792 participants. Interventions: None. Measurements and Main Results: The health-related quality of life before ICU admission; at 15 days; and at […]
Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
In this study, we identified three novel mutations as well as two recurrent mutations in the APC in five Chinese FAP families by sequencing. Immunohistochemical analysis revealed that among these mutations, a nonsense mutation (c.2510C>G) and two small deletions (c.2016_2047del, c.3180_3184del) led to the truncation of the APC protein and the cytoplasmic and nuclear accumulation […]
Higher EZH2 expression is associated with extramedullary infiltration in acute myeloid leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Abstract Accumulating evidence indicates that enhancer of zeste homolog 2 (EZH2) promotes the metastatic ability of solid tumors, but the role of EZH2 in extramedullary infiltration (EMI) in acute myeloid leukemia (AML) has not been thoroughly explored. In the present study, we investigated the possible association between EZH2 and EMI. We found that the messenger […]
Guideline on Muscle-Invasive and Metastatic Bladder Cancer (European Association of Urology guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement ASCO SPECIAL ARTICLE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
Purpose To endorse the European Association of Urology guideline on muscle-invasive (MIBC) and metastatic bladder cancer. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The guideline on MIBC and metastatic bladder cancer was reviewed for […]
What Is the Malignancy Risk in Neurofibromatosis Type 1? EDITORIAL
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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Reply to N. Lowy et al and to D. Dhanda et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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Reply to S. Kilickap et al, Y. Karakas et al, and I.A. Voutsadakis CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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Better Evidence About Older Adults With Cancer Will Not Improve Survival Rates Alone; Clinicians Need More Support CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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US Food and Drug Administration and Representation of Older Adults in Clinical Trials CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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Radiation Therapy and the Evolving Definition of Low Risk in Ductal Carcinoma in Situ CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 27 δευτερόλεπτα
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Effect of carbonated drink on excisional palatal wound healing
[image: http:--www.ijdr.in-images-linkout.gif] Authors: Suragimath G, Krishnaprasad KR, Moogla S, Sridhara SU, Raju S Abstract BACKGROUND: Millions of people worldwide consume carbonated drinks every day. The effects of these drinks on hard tissues in the mouth have been proved beyond doubt. Only a little has been done so far to assess the effects of carbonated drinks on oral soft tissues. This study was an attempt to assess the effect of carbonated drinks on oral wound healing. MATERIALS AND METHODS: Twenty female Wistar rats were considered for the study. A circular wound was cr... περισσότερα »
Perforation of nasal septum and palate caused by iatrogenic foreign body in nose and rhinolith
[image: http:--journal.yiigle.com-r-cms-jiansuo-] Authors: Bao XL, Cai KM PMID: 21055052 [PubMed - indexed for MEDLINE]
Rhinologic and sinonasal changes in PR3 ANCA pulmonary vasculitis.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Zycinska K, Wardyn KA, Piotrowska E, Zielonka TM, Zycinski H, Bogaczewicz A, Nitsch-Osuch A, Miskiewicz M, Smolarczyk R Abstract BACKGROUND: Over 70-95% patients with PR3 ANCA pulmonary vasculitis present with upper respiratory tract symptoms or sings. Nasal cavity usually presents with obstruction and chronic refractory infections (rhinosinusitis) which commonly manifest as bloody discharge or crusting obstruction. Mucopurulent discharge may occur in the acute phase or remission, along with other symptoms suggesting sinus... περισσότερα »
Adenoid cystic carcinoma with hard palate perforation.
An unusual case of adenoid cystic carcinoma with hard palate perforation.: Authors: Ferrazzo KL, Schneider PP, Shinohara EH Abstract Adenoid cystic carcinoma is a malignant tumor which occurs frequently in hard palate associated with minor salivary glands. The lesion generally presents as a painful slow growing mass and it is characterized by recurrences and distant metastasis resulting in a poor prognosis for the patient. This paper reports an atypical adenoid cystic carcinoma with palatal perforation which occurred in a young woman. Initial diagnostic hypothesis were necrotizing ... περισσότερα »
Saddle nose deformity, palatal perforation and truncus arteriosus in a patient with Crohn's disease.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Oghan F, Pekkan G, Ozveren O Abstract Crohn's disease (CD) is a chronic granulomatous inflammatory bowel disease which may also involve the extraintestinal organs such as joints, liver, skin and perianal tissue. Involvement of the nasal cavity is quite rare in CD. This case report presents a 28-year-old girl with CD and saddle nose deformity, alar collapse and palatal perforation as extraintestinal manifestations of the disease in addition to persistent truncus arteriosus-type 4. PMID: 21306908 [PubMed - indexed for MEDLI... περισσότερα »
Sequence of oral manifestations in rhino-maxillary mucormycosis.
[image: http:--www.ijdr.in-images-linkout.gif] Authors: Doni BR, Peerapur BV, Thotappa LH, Hippargi SB Abstract Mucormycosis, caused by saprophytic fungi of the order Mucorales of the class Zygomycetes, is a rare opportunistic fungal infection, which has a rapidly progressive and fulminant course with fatal outcome. These fungi are ubiquitous, found in soil, bread molds, decaying fruits and vegetables. The most common form of mucormycosis is rhinocerebral and is usually seen in uncontrolled diabetes mellitus or in immunocompromised patients. This fungus invades the arteries, leadi... περισσότερα »
Angiomatoid fibrous histiocytoma on the hard palate
[image: http:--production.springer.de-OnlineReso] Authors: Song JY, Lee SK, Kim SG, Rotaru H, Baciut M, Dinu C Abstract BACKGROUND: Angiomatoid fibrous histiocytoma (AFH) is a rare, soft tissue sarcoma, which is slow growing with low metastatic potential. We recently had a patient present with AFH, which had a palatal perforation and it looked like a cyst in the occlusal view. Therefore, the radiological and histological features of AFH are reported herein. In addition, the differential diagnosis for this lesion is also discussed with a review of the literature. CASE REPORT: A 23... περισσότερα »
Giant desmoplastic fibroma in the anterior zone of the maxilla.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Authors: Mir-Mari J, Aguirre-Urizar JM, Berini-Aytés L, Gay-Escoda C Abstract Desmoplastic fibroma (DF) is a rare intraosseous benign neoplasm that represents less than 1% of the osseous tumors. This lesion can be locally aggressive, and the rate of recurrence is frequently high.A 34-year-old male patient was referred to our clinic presenting a tumor in the anterior zone of the maxilla. The oral examination revealed a hard and lobulated tumor, affecting teeth 13 to 26. The radiographic examination, orthopantomography, and computed ... περισσότερα »
Extranodal nasal-type NK/T-cell lymphoma of the palate and paranasal sinuses.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Nikolaos N, Grigorios P, Konstantinos K, Savvas T, Vassiliki Z, Alexandra S, Theodoros P Abstract BACKGROUND: Extranodal nasal-type natural killer (NK)/T-cell lymphoma represents a rare entity, typically originating in the nasal cavity, palate or midfacial region. Signs and symptoms include non-specific rhinitis and/or sinusitis, nasal obstruction, epistaxis, facial swelling and development of deep necrotic ulceration in the midline of the palate, causing an oronasal defect. Differential diagnosis includes fungal infectio... περισσότερα »
Myofibromas of the jaws in children.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Abramowicz S, Simon LE, Kozakewich HP, Perez-Atayde AR, Kaban LB, Padwa BL Abstract PURPOSE: Controversy exists as to the most appropriate treatment strategy for myofibromas of the jaws: en bloc resection versus enucleation. The purpose of the present study was to evaluate the treatment outcomes in children with these uncommon benign tumors. MATERIALS AND METHODS: We performed a retrospective chart review of pediatric patients with jaw myofibromas. The predictor variables included patient demographics, clinical presentat... περισσότερα »
Traumatic palatal perforation after orotracheal intubation
Traumatic palatal perforation after orotracheal intubation: a case report and a review of the literature.: Authors: Bartlett E, Mahabir RC, Verheyden CN Abstract In this report, we describe an unusual case of a traumatic palatal perforation caused by orotracheal intubation. The paucity of reports of palatal perforation resulting from intubation in the literature suggests that it is a rare occurrence. However, recognizing this potential complication and managing the airway appropriately may reduce patient morbidity. PMID: 22409588 [PubMed - in process]
Nasal septum perforation in patient with pyoderma gangrenosum.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Maia CB, Felix F, Paes V, de Azevedo JA, Grangeiro ER, Riccio JL, Rito HC Abstract INTRODUCTION: The cocaine is obtained from the leaves of the coca (Erythroxylon coca). It can be used in many ways, but the most common is the drug inhalation. The Cocaine also causes vasoconstriction at nasal mucous membrane and its chronic use can cause necrosis and nasal septum perforation. Pyoderma gangrenosum is an uncommon idiopathic disease characterized by ulcerations, usually observed on the legs. Its diagnosis is most common an ex... περισσότερα »
Ear discharge with central perforations in tympanic membranes, palatal paralysis and trismus : Otogenic tetanus.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Adeel M, Rajput SA, Awan MS, Arain A Abstract The authors are presenting our experience of managing an interesting case of a 12-year-old girl who presented to our clinic with otorrhea for 3 months and trismus for 1 week. Examination showed bilateral ear discharge with central perforations in tympanic membranes, palatal paralysis and trismus. Systemic examination revealed only mild stiffness of hand muscles. CT-scan head and neck was done to look for intracranial complicatio... περισσότερα »
Repair of a perforated sinus membrane with a subepithelial palatal conjunctive flap
[image: http:--images.hindawi.com-linkout-hindaw] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Gehrke SA, Taschieri S, Del Fabbro M, Corbella S Abstract The maxillary sinus grafting procedure has proven to be an acceptable modality for bone augmentation to provide a base for endosseous implants, routinely used for the rehabilitation of posterior maxilla. Perforation of the membrane is the most common complication in this type of procedure. This paper presents a technique for repairing a perforated Schneiderian membrane with a conjunctive connective tissue graft harve... περισσότερα »
Differential diagnosis of Wegener's granulomatosis and extranodal NK/T-cell lymphoma, nasal type
[Differential diagnosis of Wegener's granulomatosis and extranodal NK/T-cell lymphoma, nasal type].: Authors: Vasil'ev VI, Sedyshev SKh, Gorodetskiĭ BP, Probatova NA, Gaĭduk IV, Logvinenko OA, Nikitin SS, Silin AIu, Lesniak VN, Nasonov EL Abstract Men aged over 40 years more commonly develop NK/T-cell lymphomas (NK/T-CL). The paper describes a case of NK/T-CL in a 20-year-old man. Despite the fact that the disease (nasal septum perforation, hard palate bone destruction, recurrent nasopharyngeal bleeding, considerable weight loss, and high erythrocyte sedimentation rate,) progressed...περισσότερα »
T cell non-Hodgkin's lymphoma with colesional mucormycosis presenting as palatal perforation
T cell non-Hodgkin's lymphoma with colesional mucormycosis presenting as palatal perforation: a case report.: Authors: Khan AA, Garg A, Dhawan S, Agarwal PK, Siraj F, Aggarwal S Abstract Non-Hodgkin's lymphoma (NHL) is predominantly a disease of lymph nodes, but extranodal involvement is not very uncommon. Palatal involvement by NHL is rare. Mucormycosis is a devastating fungal infection commonly seen in immunocompromised individuals, including those with NHL, but it is affecting the same region has been reported very rarely. Simultaneous infiltration of hard palate by NHL and muco... περισσότερα »
Spontaneous exposition of a midline palatal torus
[Spontaneous exposition of a midline palatal torus].: [image: http:--www.scielo.org.co-img-scielo.gif] Authors: Sinisterra G, Álvarez J, Molano PE Abstract INTRODUCTION: Palatal torus, or torus palatinus, is a benign bone alteration that may cause some discomfort during phonation or swallowing. When its growth or persistent exposition produces unpleasant symptoms, it must be surgically removed. CASE PRESENTATION: We treated an 82-year-old female patient who consulted for a painful ulcerous lesion she had had for a year and which produced halitosis and discomfort when swallowing. ... περισσότερα »
AVSimultaneous radicular cyst and mucoepidermoid carcinoma in the maxilla
Simultaneous radicular cyst and mucoepidermoid carcinoma in the maxilla: a diagnostic nightmare.: [image: http:--highwire.stanford.edu-icons-exter] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Nabil S, Lo RC, Choi WS Abstract We present a case of a 20-year-old woman presenting initially with an asymptomatic palatal swelling. Radiographic examination showed a cyst at the right maxilla with bucco-lingual expansion and perforation of palatal bone. Incisional biopsy was carried out via a buccal approach and the result revealed a benign odontogenic cyst, in keeping with... περισσότερα »
Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity
[image: http:--www.ijstd.org-images-linkout.gif] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Balaji G, Kalaivani S Abstract Late congenital syphilis refers to the people with syphilis from the age of 2 to 30 years. We report a case of late congenital syphilis in a 9 year old girl with perforation of palate and saddle nose deformity. Kassowitz law was also observed (if a woman with untreated syphilis has series of pregnancies, the likelihood of infection of the fetus in later pregnancies becomes less). Venereal Disease Research Laboratory (VDRL) and Treponema palli... περισσότερα »
Toothpick ingestion
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *Radiological diagnosis of a small bowel perforation secondary to toothpick ingestion.* Authors: Mark D, Ferris K, Martel G, Mulholland K Abstract A 77-year-old edentulous man presented to the accident and emergency department with a sudden onset of sharp right-sided abdominal pain. The patient reported a change in his bowel habit with constipation over a 6 month period but did not report any significant choking event or ingestion of a foreign body in the preceding months. On exami... περισσότερα »
Expansile nasopalatine duct cyst (NPDC) causing extensive destruction of the hard palate with involvement of the nasal cavity, perforation of the alveolar process and mucosa of the maxilla by pressure of the maxillary anterior teeth
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *An unusually large destructive nasopalatine duct cyst: a case report.* Authors: Perumal CJ Abstract A case of an unusually large expansile nasopalatine duct cyst (NPDC) causing extensive destruction of the hard palate with involvement of the nasal cavity, perforation of the alveolar process and mucosa of the maxilla by pressure of the maxillary anterior teeth is being presented. PMID: 24431822 [PubMed]
Palatal perforation secondary to tuberculosis
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Sharma R, Sirohi D, Sinha R, Menon PS Abstract Palatal perforation though rarely seen in adults but may have infectious, inflammatory, neoplastic, or traumatic cause. We present here a case of palatal perforation due to tuberculosis which was managed successfully using greater palatine artery pedicled flap closure at our centre. PMID: 24431861 [PubMed]
[Radiation therapy of sinonasal natural killer/T-cell lymphoma].
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Riet FG, Canova CH, Gabarre J, Ben Hassine S, Kamsu Kom L, Mazeron JJ, Feuvret L Abstract Natural killer (NK)/T-cell lymphoma are part of lymphoproliferative diseases, they are rare in Europe and the United States but relatively common in Asia and South America. Natural killer (NK)/T-cell lymphoma present clinically as destructive lesions of the upper aerodigestive tract with perforation of deep structures of the face, destruction of the palate or an invasion of orbits. Treatment modalities of these lymphomas are still di... περισσότερα »
Ameloblastic carcinoma
[image: http:--www.wjgnet.com-files-bpg.gif] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Srikanth MD, Radhika B, Metta K, Renuka NV Abstract Ameloblastic carcinoma is a rare odontogenic tumor exhibiting histological evidence of malignancy in the primary or recurrent tumor. It is characterized by rapid, painful expansion of the jaw, unlike conventional ameloblastomas. The tumor most frequently involves the mandible. The expanding lesion causes perforation of the buccal and lingual plates of the jaw and invades the surrounding soft tissue. Rapidly growing large tumor... περισσότερα »
Curative effect observation of plasma eardrum perforation homochronous with palatoplasty in the treatment of chronic secretory otitis media
[Curative effect observation of plasma eardrum perforation homochronous with palatoplasty in the treatment of chronic secretory otitis media].: Authors: Zhang K, Zhang J, Zhang J, Wang B, Wang L Abstract OBJECTIVE: To investigate the effect of plasma eardrum perforation homochronous with palatoplasty on hearing and tympanic cavity pressure in cleft palate children with secretory otitis media. METHOD: Fifty-six cases of cleft palate children with secretory otitis media were randomly divided into observation group and control group. For the control group, palatoplasty was carried out...περισσότερα »
Infliximab for refractory oral ulcers.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Ryu HJ, Seo MR, Choi HJ, Baek HJ Abstract Recurrent oral ulcer (ROU) is a common condition that significantly impacts quality of life. It is often related to systemic diseases, such as Behçet's disease (BD), Crohn's disease, and ulcerative colitis. Treatment of ROU depends on its severity: from topical agents for mild cases to systemic agents, such as corticosteroids, azathioprine, or other immunosuppressants for severe cases. Recently, good results have been reported with infliximab in refractory ROU. However, the optimal... περισσότερα »
Brain hypoxia is exacerbated in hypobaria during aeromedical evacuation in swine with TBI.
Background: There is inadequate information on the physiological effects of aeromedical evacuation on wounded warfighters with traumatic brain injury (TBI). At altitudes of 8,000 ft., the inspired oxygen is lower than standard sea level values. In troops suffering TBI, this reduced oxygen may worsen or cause secondary brain injury. We tested the hypothesis that the effects of prolonged aeromedical evacuation on critical neurophysiological parameters (i.e., brain oxygenation [PbtO2]) of swine with a fluid percussion injury (FPI) -TBI would be detrimental compared to ground (normobari... περισσότερα »
Cervical spine injuries in civilian victims of explosions: Should cervical collars be used?.
Background: Semi-rigid cervical collars (SRCC) are routinely applied to victims of explosions as part of the pre-hospital trauma protocols. Previous studies have shown that the use of SRCC in penetrating injuries is not justified due to the scarcity of unstable cervical spine injuries and the risk of obscuring other neck injuries. Explosion can inflict injuries by fragments penetration, blast injury, blunt force and burns. The study purpose was to determine the occurrence of cervical spine instability without irreversible neurological deficit and other potentially life threatening n... περισσότερα »
Not child's play: National estimates of microwave-related burn injuries among young children.
Background: Previous studies have shown that children as young as 18-months-old can open a microwave and remove its contents causing sometimes severe scalds. Though this mechanism may be uniquely preventable by an engineering fix, no national estimate of this type of child burn injury has been reported. Methods: We analyzed the Consumer Product Safety Commission's National Electronic Injury Surveillance System data on emergency department-treated microwave-related burn injuries from January 2002 through December 2012 in children aged 12-months to 4-years. Based on the narrative desc...περισσότερα »
Current insight into pathophysiology of gastroduodenal ulcers: Why do only some ulcers perforate?.
Complicated peptic ulcer disease represents a considerable health burden worldwide. Perforation occurs in a minority of ulcers, but is associated with considerable morbidity and mortality. Demographic changes in populations have caused a shift in location, type and outcomes for perforated peptic ulcers. Unlike the intense investigations into ulcerogenic factors in general, including the role of Helicobacter pylori and increasingly low-dose aspirin drugs, little is known about factors contributing to perforation per se. The balance between acidity and protective and restorative facto... περισσότερα »
Utilizing social media for community consultation and public disclosure in exception from informed consent trials.
BACKGROUND: The U.S. Food and Drug Administration and Department of Health and Human Services outline regulations allowing an Exception From Informed Consent (EFIC) for research conducted in an emergency settings. Acute care clinical trials utilizing EFIC must include community consultation and public disclosure (CC/PD) activities. We describe our experience using social media to facilitate the CC/PD process in two trauma resuscitation clinical trials. METHODS: We conducted local CC/PD activities for two multicenter trauma clinical trials, Pragmatic, Randomized Optimal Platelet and ...περισσότερα »
Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction
Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction: Abstract The diabetic foot ulcer (DFU) is the leading cause of lower extremity amputation worldwide and is directly associated with comorbidity, disability and mortality. Oxidative stress mechanisms have been implicated in the pathogenesis of these wounds. Intra-lesional infiltration of epidermal growth factor has emerged as a potential therapeutic alternative to allow for physiological benefit while avoiding the proteolytic environment at th... περισσότερα »
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein [Melanoma]
Purpose To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement. Materials and Methods Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date ... περισσότερα »
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein [Melanoma]
Purpose To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement. Materials and Methods Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date ... περισσότερα »
Association of Vitamin D Levels With Outcome in Patients With Melanoma After Adjustment For C-Reactive Protein [Melanoma]
Purpose To evaluate for an association between 25-hydroxyvitamin D levels (vitamin D) and outcome measures in patients with melanoma after evaluation is controlled for systemic inflammatory response (SIR) on the basis of simultaneous C-reactive protein (CRP) measurement. Materials and Methods Plasma samples from 1,042 prospectively observed patients with melanoma were assayed for vitamin D and CRP. The associations of demographics and CRP with vitamin D were determined, followed by a determination of the association between vitamin D and stage and outcome measures from the date ... περισσότερα »
In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS
Polyspecific T cells recognizing multiple distinct self-antigens have been identified in multiple sclerosis and other organ-specific autoimmune diseases, but their pathophysiological relevance remains undetermined. Using a mouse model of multiple sclerosis, we show that autoimmune encephalomyelitis induction is strictly dependent on reactivation of pathogenic T cells by a peptide (35–55) derived from myelin oligodendrocyte glycoprotein (MOG). This disease-inducing response wanes after onset. Strikingly, the progression of disease is driven by the *in situ* activation and expansion... περισσότερα »
Pneumococcal meningitis: Clinical-pathological correlations (meningene-path)
Abstract Pneumococcal meningitis is associated with substantial mortality and morbidity. We systematically assessed brain histopathology of 31 patients who died of pneumococcal meningitis from a nationwide study (median age 67 years; 21 (67 %) were male) using a pathology score including inflammation and vascular damage. Of the 27 patients with known time from the admission to death, 14 patients died within 7 days of admission and 13 after 7 days of admission. Eleven of 25 (44 %) patients had been treated with adjunctive dexamethasone therapy. Observed pathological processes were ...περισσότερα »
MANAGEMENT OF CANCER WITH MUNZIJ AND MUS’HIL THERAPY: A REGIMEN OF ILAJ BIT TADBEER (REGIMENAL THERAPY) IN UNANI SYSTEM OF MEDICINE
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 56 δευτερόλεπτα
2016-03-21T23-32-13Z *Source:* International Journal of Current Research and Review Yasmeen Shamsi, Asim Ali Khan, Tabassum Alam, Azhar Jabeen. Cancer is one of the most perplexing diseases which have been plaguing worldwide and had been accounted for 8.2 million of all deaths in 2012 as reported by World Health Organization (WHO) in 2014.According to WHO, it is the second leading cause of death in the developing countries after cardiovascular diseases. American Cancer Society defines it as a large group of diseases, all characterized by uncontrolled growth and spread of abnormal ce...περισσότερα »
DEVELOPMENT AND ANALYSIS OF OIL FINISH ON COTTON FABRIC
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 56 δευτερόλεπτα
2016-03-21T23-32-13Z *Source:* International Journal of Current Research and Review S. Grace Annapoorani, S. Yamuna Devi. Aim: In the present scenario of environmental consciousness the requirement of environment friendly textiles is increased. Plant extracts and oils demonstrating antifungal properties may provide protection for textile application. Methodology: This study was to evaluate the antifungal properties of natural plant extracts, such as essential oils, for se on wood. Three essential oils were evaluated for their ability to inhibit growth of Aspergillus Niger, Trichoder... περισσότερα »
Tea tree oil gel for mild to moderate acne; a 12 week uncontrolled, open-label phase II pilot study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Abstract Background The efficacy, tolerability and acceptability of a tea tree oil gel (200 mg/g) and face wash (7 mg/g) were evaluated for the treatment of mild to moderate facial acne. Methods In this open-label, uncontrolled phase II pilot study, participants applied tea tree oil products to the face twice daily for 12 weeks and […]
Mortality risk from comorbidities independent of triple-negative breast cancer status: NCI-SEER-based cohort analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Abstract Purpose A comparatively high prevalence of comorbidities among African-American/Blacks (AA/B) has been implicated in disparate survival in breast cancer. There is a scarcity of data, however, if this effect persists when accounting for the adverse triple-negative breast cancer (TNBC) subtype which occurs at threefold the rate in AA/B compared to white breast cancer patients. […]
Quetiapine use in adults in the community: a population-based study in Alberta, Canada
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 58 δευτερόλεπτα
Objective The objective of this study was to evaluate trends in prescribing of the second-generation antipsychotic medication quetiapine to adults in the province of Alberta from 2008 to 2013 through examination of dispensed prescriptions, and diagnoses associated with users of quetiapine in 2013. Methods We analysed administrative data from Alberta Health; the Alberta Pharmaceutical Information […]
Current status of pregnancy-related maternal mortality in Japan: a report from the Maternal Death Exploratory Committee in Japan
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Objective To clarify the problems related to maternal deaths in Japan, including the diseases themselves, causes, treatments and the hospital or regional systems. Design Descriptive study. Setting Maternal death registration system established by the Japan Association of Obstetricians and Gynecologists (JAOG). Participants Women who died during pregnancy or within a year after delivery, from 2010 […]
Impact of socioeconomic deprivation on screening for cardiovascular disease risk in a primary prevention population: a cross-sectional study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 59 δευτερόλεπτα
Objectives Investigate the association between socioeconomic deprivation and completeness of cardiovascular disease (CVD) risk factor recording in primary care, uptake of screening in people with incomplete risk factor recording and with actual CVD risk within the screened subgroup. Design Cross-sectional study. Setting Nine UK general practices. Participants 7987 people aged 50–74 years with no CVD […]
Cardiac rehabilitation referral and enrolment across an academic health sciences centre with eReferral and peer navigation: a randomised controlled pilot trial
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives To describe (1) cardiac rehabilitation (CR) referral across cardiac units in a tertiary centre with eReferral; (2) characteristics associated with CR referral and enrolment and (3) the effects of peer navigation (PN) on referral and enrolment. This pilot was a 2 parallel-arm, randomised, single-blind trial with allocation concealment. Setting 3 cardiac units (ie, interventional, […]
Women’s knowledge and attitudes surrounding abortion in Zambia: a cross-sectional survey across three provinces
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives In Zambia, despite a relatively liberal legal framework, there remains a substantial burden of unsafe abortion. Many women do not use skilled providers in a well-equipped setting, even where these are available. The aim of this study was to describe women’s knowledge of the law relating to abortion and attitudes towards abortion in Zambia. […]
Comparative analysis of premature mortality among urban immigrants in Bremen, Germany: a retrospective register-based linkage study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objectives The main objective of this study was to explore differences in mortality patterns among two large immigrant groups in Germany: one from Turkey and the other from the former Soviet Union (FSU). To this end, we investigated indicators of premature mortality. Design This study was conducted as a retrospective population-based study based on mortality […]
Perceptions and impact of plain packaging of tobacco products in low and middle income countries, middle to upper income countries and low-income settings in high-income countries: a systematic review of the literature
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To review the current literature around the potential impact, effectiveness and perceptions of plain packaging in low income settings. Method A systematic review of the literature. Data sources 9 databases (PubMed, Global Health, Social Policy and Practice, Applied Social Sciences Index and Abstracts (ASSIA), CINAHL, PsycINFO, British Library for Development Studies (BLDS), Global Health […]
Long-Term Survival, Quality of Life, and Quality-Adjusted Survival in Critically Ill Patients With Cancer.
Objectives: To assess the long-term survival, health-related quality of life, and quality-adjusted life years of cancer patients admitted to ICUs. Design: Prospective cohort. Setting: Two cancer specialized ICUs in Brazil. Patients: A total of 792 participants. Interventions: None. Measurements and Main Results: The health-related quality of life before ICU admission; at 15 days; and at… Continue reading Long-Term Survival, Quality of Life, and Quality-Adjusted Survival in Critically Ill Patients With Cancer.
Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis
In this study, we identified three novel mutations as well as two recurrent mutations in the APC in five Chinese FAP families by sequencing. Immunohistochemical analysis revealed that among these mutations, a nonsense mutation (c.2510C>G) and two small deletions (c.2016_2047del, c.3180_3184del) led to the truncation of the APC protein and the cytoplasmic and nuclear accumulation… Continue reading Three novel mutations of APC gene in Chinese patients with familial adenomatous polyposis
Higher EZH2 expression is associated with extramedullary infiltration in acute myeloid leukemia
Abstract Accumulating evidence indicates that enhancer of zeste homolog 2 (EZH2) promotes the metastatic ability of solid tumors, but the role of EZH2 in extramedullary infiltration (EMI) in acute myeloid leukemia (AML) has not been thoroughly explored. In the present study, we investigated the possible association between EZH2 and EMI. We found that the messenger… Continue reading Higher EZH2 expression is associated with extramedullary infiltration in acute myeloid leukemia
Guideline on Muscle-Invasive and Metastatic Bladder Cancer (European Association of Urology guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement ASCO SPECIAL ARTICLE
Purpose To endorse the European Association of Urology guideline on muscle-invasive (MIBC) and metastatic bladder cancer. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The guideline on MIBC and metastatic bladder cancer was reviewed for… Continue reading Guideline on Muscle-Invasive and Metastatic Bladder Cancer (European Association of Urology guideline): American Society of Clinical Oncology Clinical Practice Guideline Endorsement A... περισσότερα »
What Is the Malignancy Risk in Neurofibromatosis Type 1? EDITORIAL
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Optimizing Treatment Risk and Benefit for Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Right Treatment for the Right Patient ONCOLOGY GRAND ROUNDS
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers… Continue reading Optimizing Treatment Risk and Benefit for Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Right Treatment for the Right Patient ONCOLOGY GRAND ROUNDS
Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013 Breast Cancer
Purpose The objective of this study was to determine whether the 21-gene Recurrence Score (RS) provides clinically meaningful information in patients with de novo stage IV breast cancer enrolled in the Translational Breast Cancer Research Consortium (TBCRC) 013. Patients and Methods TBCRC 013 was a multicenter prospective registry that evaluated the role of surgery of… Continue reading Prognostic Impact of 21-Gene Recurrence Score in Patients With Stage IV Breast Cancer: TBCRC 013 Breast Cancer
Window-of-Opportunity Trials in the Preoperative Setting: Insights Into Drug Development for Estrogen Receptor-Positive Breast Cancer EDITORIAL
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Antiangiogenic Therapy for Glioblastoma: Complex Biology and Complicated Results EDITORIAL
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Incorporating Androgen Deprivation With Dose-Escalated External-Beam Radiotherapy for Prostate Cancer ONCOLOGY GRAND ROUNDS
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers… Continue reading Incorporating Androgen Deprivation With Dose-Escalated External-Beam Radiotherapy for Prostate Cancer ONCOLOGY GRAND ROUNDS
Rheumatic diseases and blood cancers involving the nasal cavity and accessory sinuses
[Differential diagnosis of rheumatic diseases and blood cancers involving the nasal cavity and accessory sinuses] Authors: Vasil'ev VI, Sokol EV, Sedyshev SKh, Gorodetskiĭ VR, Aleksandrova EN, Logvinenko OA, Pal'shina SG, Rodionova EB, Radenska-Lopovok SG, Probatova NA, Kokosadze NV, Pavlovskaia AI, Kovrigina AM, Varlamova EIu, Safonova TN, Borovskaia AB, Gaĭduk IV, Mukhortova OV, Aslanidi IP, Nasonov EL Abstract AIM: To provide the clinical, laboratory, radiological, morphological, and immunomorphological signs that permit the differential diagnosis to be made in patients with in... περισσότερα »
Progressive midfacial bone erosion and necrosis
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Bianchi FA, Gerbino G, Tosco P, Tanteri G, Gatti G, Ramieri G Abstract A 31-year-old woman presented with a large oro-nasal communication (ONC), loss of vomer and significant nasal cartilage and nose deformity. Physical examination of the patient revealed a typical midline destructive lesion (MDL) with nasal septum and hard/soft palate perforation with a friable granular surface and a large amount of necrotic tissues. Medical history was unremarkable and the patient denied previous local trauma, including surgical procedur... περισσότερα »
Intranasal abuse of combined opioid-acetaminophen medications.
[image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Vosler PS, Ferguson BJ, Contreras JI, Wang EW, Schaitkin BM, Lee S Abstract BACKGROUND: The nonmedical abuse of prescription opioids via intranasal administration is a growing problem. The objective of this study is to investigate of the typical presentation of intranasal opioid-acetaminophen abuse and outline optimal therapy. METHODS: This study was a retrospective chart review. Patients with intranasal pathology from inhalation of combined opioid-acetaminophen medications (COAMs) from 3 academic otolaryngology practices ... περισσότερα »
Rhinomaxillary mucormycosis with palatal perforation
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Sreenath G, Prakash AR, Kanth MR, Reddy PS, Vidhyadhari P Abstract Mucormycosis are a group of invasive infections caused by filamentous fungi of the Mucoraceae family. Mucormycosis is essentially limited to immunocompromised patients with poorly controlled diabetes mellitus, hematologic malignancy, organ transplant, chemotherapy, chronic renal insufficiency, malnutrition, deferoxamine therapy and severe burns. The fungi invade arteries leading to thrombosis that subsequently causes necrosis of hard and soft tissues. Here,... περισσότερα »
Pseudotumoral nasal septum and hard palate perforation
[image: http:--www.masson.fr-images-Medline-goto] Ann Pathol. Authors: Boulagnon C, Kovacs OB, Patey M Abstract We report a case of pseudotumoral nasal septum and hard palate perforation in a 42-years-old man. The diagnosis retained after differential diagnosis exclusion was necrotic midfacial lesion due to chronic inhalation of cocaine. This condition can mimic vasculitis, primary tumors and granulomatous infections. Differential diagnosis and pathophysiology of this condition will be discussed in this anatomo-clinical case. PMID: 25778762 [PubMed - indexed for MEDLINE]
Palatal perforation, the most rarely observed complication after deviated septum surgery.
[image: http:--jpma.org.pk-images-jpma_banner.jp] Authors: Gökdemir O, Bal A Abstract Numerous complications after septoplasty have been identified in the literature. Blindness and palatal perforation are among the rarest complications. The palatal perforation experienced by the presented patient was because he was not thoroughly examined before surgery. Secondly, we wanted to emphasize the fact that care must be taken during septoplasty operation, particularly while performing the intervention to the inferior septal area. PMID: 25831658 [PubMed - indexed for MEDLINE]
Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions
Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report J Neurosurg Spine. Authors: Brembilla C, Lanterna LA, Risso A, Bombana E, Gritti P, Trezzi R, Bonaldi G, Biroli F Abstract With the increasingly widespread illicit use of cocaine, a broad spectrum of clinical pathologies related to this form of drug abuse is emerging. The most frequently used method of administration of powdered cocaine is intranasal inhalation, or "snorting." Consequently, adverse effects of cocaine on the nasal tract are common. Habitual nasal insuffl... περισσότερα »
[Hard palate fistula and nasal septum perforation after leukemia infection: report of one case].
[Hard palate fistula and nasal septum perforation after leukemia infection: report of one case].: Authors: Sun L Abstract Most of palatal fistula occur from poor repairation of cleft palate, leaving an abnormal channel between mouth and nose. Palatal fistula can cause a series of complications, such as voice and hearing disorder, poor oral and nasal hygiene, psychological diseases and so on. However, hard palate fistula secondary to Leukemia infection is rarely seen, it hasn't been reported yet. We report one case with hard palate fistula and nasal septum perforation after Leukemi... περισσότερα »
Corticotomy-assisted rapid maxillary expansion for treating a severe maxillary transverse discrepancy
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Echchadi ME, Benchikh B, Bellamine M, Kim SH Abstract This case report introduces a new approach of corticotomy-assisted rapid maxillary expansion for treating a severe maxillary transverse discrepancy in a skeletally mature patient. This approach uses piezo-bone perforation in conjunction with a fixed appliance and an expander. This report describes the treatment of a 14-year-old girl with a severe maxillary transverse discrepancy. She had a straight profile, severe maxillary crowding, a maxillomandibular transverse diffe... περισσότερα »
Chronic invasive fungal sinusitis associated with intranasal drug use.
[image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Pekala KR, Clavenna MJ, Shockley R, Weiss VL, Turner JH Abstract Chronic invasive fungal sinusitis (CIFS) is a rare but potentially aggressive form of invasive fungal disease that occurs in immunocompetent patients. We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Biopsy demonstrated invasive Aspergillus flavus requiring surgical debridement and extended intravenous antifungal therapy. Tis... περισσότερα »
A necrotic plaque lesion on the soft palate : Hemophagocytic lymphohistiocytosis (HLH)
A Hemophagocytic Lymphohistiocytosis Case with Newly Defined UNC13D (c.175G>C; p.Ala59Pro) Mutation and a Rare Complication.: Turk J Haematol. Authors: Balcı YI, Özgürler Akpınar F, Polat A, Kenar F, Tesi B, Greenwood T, Yalçın N, Koçyiğit A Abstract Hemophagocytic lymphohistiocytosis (HLH) represents a severe hyperinflammatory condition with cardinal symptoms of prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages with impaired function of natural killer cells and cytotoxic T lymphocytes. A 2-month-old girl, who wa... περισσότερα »
Squamous cell carcinoma on a syphilitic gumma
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Indian J Sex Transm Dis. Authors: Rahima S, Riyaz N, Latheef EN, Shyni PM Abstract Gumma is a characteristic lesion of tertiary syphilis that is rare nowadays, but still rarer is squamous cell carcinoma (SCC) arising from it. A 74-year-old male presented with throat pain and nasal twang with a past history of genital ulcer. Examination revealed a well-defined ulcer with a perforation of 1.5 cm over the hard palate with induration and nodularity at the margins. This patient also had leukoplakia over the ventral aspect of the tongue... περισσότερα »
Suction Cup-Induced Palatal Perforation
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] *A Surgical Technique for the Management of Suction Cup-Induced Palatal Perforation: A Technical Note.* J Clin Diagn Res. Authors: Rahpeyma A, Khajehahmadi S Abstract Suction cap-induced palatal perforation is uncommon today. In the surgical management of such a complication, the surgeon should consider the large bony defect hidden behind the small slit in the palatal mucosa. In this article a case is presented,in which a combination of anteriorly based inferior turbinate flap and posteriorly based palatal submucosal flap solved... περισσότερα »
CHST14/D4ST1 deficiency: New form of Ehlers-Danlos syndrome.ultiple congenital malformations (craniofacial features including large fontanelle, hypertelorism, short and downslanting palpebral fissures, blue sclerae, short nose with hypoplastic columella, low-set and rotated ears, high palate, long philtrum, thin upper lip vermilion, small mouth, and micro-retrognathia; multiple congenital contractures including adduction-flexion contractures and talipes equinovarus as well as other visceral or ophthalmological malformations) and progressive multisystem fragility-related complications (skin hyperextensibility, bruisability, and fragility with atrophic scars; recurrent dislocations; progressive talipes or spinal deformities; pneumothorax or pneumohemothorax; large subcutaneous hematomas; and diverticular perforation)
[image: http:--media.wiley.com-assets-7315-19-Wi] Pediatr Int. 2016 ;58(2):88-99 Authors: Kosho T Abstract Carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase-1 (CHST14/D4ST1) deficiency represents a specific form of Ehlers-Danlos syndrome (EDS) caused by recessive loss-of-function mutations in CHST14. The disorder has been independently termed "adducted thumb-clubfoot syndrome", "EDS, Kosho type", and "EDS, musculocontractural type". To date, 31 affected patients from 21 families have been described. Clinically, CHST14/D4ST1 deficiency is characterized by *multiple co...περισσότερα »
Using frogs faces to dissect the mechanisms underlying human orofacial defects.
Using frogs faces to dissect the mechanisms underlying human orofacial defects.: Semin Cell Dev Biol. 2016 Mar;51:54-63 Authors: Dickinson AJ Abstract In this review I discuss how Xenopus laevis is an effective model to dissect the mechanisms underlying orofacial defects. This species has been particularly useful in studying the understudied structures of the developing face including the embryonic mouth and primary palate. The embryonic mouth is the first opening between the foregut and the environment and is critical for adult mouth development. The final step in embryonic mout... περισσότερα »
Management of a cocaine-induced palatal perforation with a nasal septal button.
Management of a cocaine-induced palatal perforation with a nasal septal button.: Authors: Trimarchi M, Sykopetrites V, Bussi M Abstract A cocaine-induced midline destructive lesion (CIMDL) is a rare consequence of cocaine insufflation that involves the nose, sinuses, and occasionally the palate. Palatal perforations compromise swallowing, mastication, and speech. An obturator prosthesis can be used to overcome these complications. In selected cases, a nasal septal button is a good alternative for the sealing of a palatal perforation, especially when surgery is not indicated, such ... περισσότερα »
Transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma.
In defence of transpalatal, transpalatal-circumaxillary (transpterygopalatine) and transpalatal-circumaxillary-sublabial approaches to lateral extensions of juvenile nasopharyngeal angiofibroma.: J Laryngol Otol. 2016 Mar ;:1-12 Authors: Mishra A, Mishra SC, Verma V, Singh HP, Kumar S, Tripathi AM, Patel B, Singh V Abstract BACKGROUND: Juvenile nasopharyngeal angiofibroma often presents with lateral extensions. In countries with limited resources, selection of a cost-effective and least morbid surgical approach for complete excision is challenging. METHODS: Sixty-three patients w...περισσότερα »
Comparison of Nasal Septum and Ear Cartilage as a Graft for Lower Eyelid Reconstruction.
[image: http:--pt.wkhealth.com-pt-pt-core-templa] J Craniofac Surg. 2016 Mar;27(2):305-7 Authors: Suga H, Ozaki M, Narita K, Kurita M, Shiraishi T, Ohura N, Takushima A, Harii K Abstract In lower eyelid reconstruction, several types of grafts from the nasal septum, ear cartilage, buccal mucosa, and hard palate mucosa have been used for an inner layer of the lower eyelid, but there have been no studies comparing these grafts. The authors retrospectively reviewed our cases of lower eyelid reconstruction, and compared chondromucosal grafts from the nasal septum (N = 8) and ear cart... περισσότερα »
Modified Todd's meatoplasty
Short CommunicationHow I do it: modified Todd's meatoplastyA N Elsamanodya1 a2 c1, V Topsakala1, W Grolmana1 and R A Tangea1 a1 Department of Otorhinolaryngology and Head and Neck Surgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, the Netherlands a2 Department of Otorhinolaryngology, Al-Hussein University Hospital, Al-Azhar University, Cairo, Egypt Abstract Background: Chronic otorrhoea after canal wall down mastoidectomy can be a clinical challenge. Basic principles for canal wall down surgery include establishing a large meatus. Several meatoplasty t...περισσότερα »
Adjuvant and Novel Treatment of Recurrent Respiratory Papillomatosis
Adjuvant and Novel Treatment of Recurrent Respiratory Papillomatosis: AbstractRecurrent respiratory papillomatosis (RRP) is a rare benign neoplasm of the respiratory tract caused by human papillomavirus types 6 and 11. Surgical removal of the papilloma by microdebridement or laser is the current standard of care, but in most cases the disease recurs and patients require repeated surgical intervention. Over time, repeated procedures can lead to complications such as significant vocal cord scarring and laryngeal stenosis. There is therefore an urgent need for adjuvant treatments or a... περισσότερα »
The risk of developing second malignancies in patients with different histological subtypes of nasopharyngeal carcinoma
A nation-wide epidemiological study on the risk of developing second malignancies in patients with different histological subtypes of nasopharyngeal carcinoma: Nasopharyngeal carcinoma (NPC) has a high incidence in Asian countries, but is a relatively uncommon tumor in western populations [1]. Its etiology is multifactorial. A possible relationship with environmental factors and a strong genetic predisposition to develop a NPC has been found [2]. Familial aggregation and susceptibility gene loci for NPC have been described [3,4]. An important etiologic and prognostic factor in NPC i...περισσότερα »
Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus
Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus: [image: gr1.sml] Human papillomavirus (HPV) type 16 (HPV 16) plays an etiologic role in the majority of cases of squamous cell carcinoma of the oropharynx (SCCOP), particularly those occurring in middle-aged patients and patients with no smoking history [1–6]. Chaturvedi et al., in an analysis of US incidence trends for oral cavity and oropharynx cancers stratified by age, demonstrated that the incidence of squamous cell carcinoma of the oral cavity (SCCOC) decreased... περισσότερα »
Reply to C. Shah et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WEALio via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
On Adjuvant Hormone Therapy in Epithelial Ovarian Cancer CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcz6Ay via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reply to T. Reinert et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WEALik via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reply to A. Korfel et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcz6As via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Reply to A. Fiorentino et al CORRESPONDENCE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WEAIDg via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Outcomes of radiofrequency ablation (RFA) and CO2 laser for early glottic cancer
Outcomes of radiofrequency ablation (RFA) and CO2 laser for early glottic cancer: [image: gr1.sml] In the present study, the voice and functional outcomes of radiofrequency ablation (RFA) and CO2 laser for early glottic cancer were evaluated. AbstractObjective In the present study, the voice and functional outcomes of radiofrequency ablation (RFA) and CO2 laser for early glottic cancer were evaluated. Methods One hundred and sixty eight patients with early glottic cancer from October 2007 to June 2015 were included. Ninety-seven patients underwent RFA and seventy-one patients... περισσότερα »
Image Guided Volumetric Response During Chemoradiotherapy for HNSCC
Image Guided Volumetric Response During Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma as a Predictor of Disease Outcomes: [image: gr1.sml] The goal of this study was to correlate volumetric image guided disease response to clinical outcomes in patients receiving chemoradiation therapy (CRT) for locally advanced head and neck squamous cell carcinoma (HNSCC). AbstractPurpose The goal of this study was to correlate volumetric image guided disease response to clinical outcomes in patients receiving chemoradiation therapy (CRT) for locally advanced head and neck squa... περισσότερα »
Epidermal growth factor (EGF) and Ofloxacin Drops in the Healing of Human Large Traumatic Eardrum Perforation
A Retrospective Study of EGF and Ofloxacin Drops in the Healing of Human Large Traumatic Eardrum Perforation: [image: gr1.sml] We evaluated the effects of epidermal growth factor (EGF) and ofloxacin otic drops on the healing of large human traumatic tympanic membrane perforations (TMPs). AbstractObjective We evaluated the effects of epidermal growth factor (EGF) and ofloxacin otic drops on the healing of large human traumatic tympanic membrane perforations (TMPs). Study Design Case series with chart review. Setting Tertiary university hospital. Methods Retrospective case revi... περισσότερα »
Endoscope Assisted Myringoplasty and Microscopic Myringoplasty
Comparative Study of Endoscope Assisted Myringoplasty and Microscopic Myringoplasty: AbstractTo study and compare the outcomes of the endoscopic versus microscopic approach to Myringoplasty in 60 patients. In this prospective study, the outcomes of 60 ears of 60 patients (40 male and 20 female) who underwent Myringoplasty were evaluated. The age range of the patients was 15–55 years. Group 1 underwent Myringoplasty with an endoscopic technique (n = 30), and Group 2 underwent Myringoplasty with the conventional microscopic technique (n = 30). A temporalis fascia graft was used in bo...περισσότερα »
Cardiac rehabilitation referral and enrolment across an academic health sciences centre with eReferral and peer navigation: a randomised controlled pilot trial
Objectives To describe (1) cardiac rehabilitation (CR) referral across cardiac units in a tertiary centre with eReferral; (2) characteristics associated with CR referral and enrolment and (3) the effects of peer navigation (PN) on referral and enrolment. This pilot was a 2 parallel-arm, randomised, single-blind trial with allocation concealment. Setting 3 cardiac units (ie, interventional, general cardiology, and cardiac surgery) in 1 of 2 hospitals of a tertiary centre. Participants CR-eligible adult cardiac inpatients were randomised to PN or usual care. 94 (54.7%) patients ... περισσότερα »
Clinical Features and Treatment of Distal Intracranial Aneurysms.
To analyze the clinical characteristics, therapies, and outcomes of distal intracranial aneurysms, the authors retrospectively studied the clinical and imaging data of 18 patients with distal intracranial aneurysms. There were 10 males and 8 females, aged from 11 months to 59 years (mean, 40.4 +/- 11.4 years). All patients were diagnosed by digital subtract angiography. Aneurysm locations were as follows: distal anterior cerebral artery (n = 5), distal middle cerebral artery (n = 2), distal posterior cerebral artery (n = 6), distal posterior inferior cerebellar artery (n = 3), dista... περισσότερα »
Changes in Corneal Curvature After Upper Eyelid Surgery Measured by Corneal Topography.
Purpose: To analyze corneal curvature changes (eg, central corneal power and corneal astigmatism) after upper eyelid surgery, and to compare the effects of different upper eyelid procedures on corneal curvature. Methods: Fifty eyes of 34 patients with various degrees of dermatochalasis or ptosis underwent corneal topography before surgery, and at 6 weeks after blepharoplasty or levator resection. Patients were divided into groups according to the method of surgery. Preoperative and postoperative changes in corneal curvature of each operated eye were compared within each group. Resul...περισσότερα »
Meta-analysis of the Incidence of Lingual Nerve Deficits After Mandibular Bilateral Sagittal Split Osteotomy.
Introduction: Bilateral sagittal split osteotomy is a relatively common maxillofacial surgical procedure. The most commonly reported complication is neurosensory disturbances (NSD). The inferior alveolar nerve is by far the most commonly affected but sporadic reports of NSD of the lingual nerve also exist. The aim of this meta-analysis is to estimate the incidence of lingual nerve NSD following bilateral sagittal split osteotomy. Materials and Methods: A systematic search of the English literature was conducted in February 2015 including several databases and using numerous MeSH term... περισσότερα »
Repair of Critical Calvarias Defects With Systemic Epimedium sagittatum Extract.
It is well established in reconstructive surgery the repair of great bone defects is a difficult goal to be achieved. The aim of this study was to evaluate the influence of an extract rich in icariin on bone neoformation in critically sized defects in rat calvaria. Under continual saline irrigation, a circular bone defect was created in 40 rat calvarias with an 8-mm diameter trephine drill. Animals were randomly divided into a test group that received an Epimedium sagittatum extract (containing 5.8 mg/mL of icariin) and a control group that received an equal volume of saline solutio... περισσότερα »
Upper Triangular Flap in Unilateral Cleft Lip Repair.
In this article, the authors describe their use of the upper triangular flap method to repair unilateral cleft lips in 250 patients with cosmetically appealing and predictable results. This method produces a straight philtral column scar that is parallel to the noncleft side and hides the surgical scars on the medial aspect of the nostril and in the lip-columellar crease. The first step is to assign the reference points along the vermilion border and the nostril sills. It is important to identify the nostril sill on the cleft nose, which could be particularly attenuated in wide clef... περισσότερα »
Directed Acyclic Graphs for Oral Disease Research
Directed acyclic graphs (DAGs) are nonparametric graphical tools used to depict causal relations in the epidemiologic assessment of exposure-outcome associations. Although their use in dental research was first advocated in 2002, DAGs have yet to be widely adopted in this field. DAGs help identify threats to causal inference such as confounders, bias due to subject selection, and inappropriate handling of missing data. DAGs can also inform the data analysis strategy based on relations among variables depicted on it. This article uses the example of a study of temporomandibular diso... περισσότερα »
Women's knowledge and attitudes surrounding abortion in Zambia: a cross-sectional survey across three provinces
Objectives In Zambia, despite a relatively liberal legal framework, there remains a substantial burden of unsafe abortion. Many women do not use skilled providers in a well-equipped setting, even where these are available. The aim of this study was to describe women's knowledge of the law relating to abortion and attitudes towards abortion in Zambia. Setting Community-based survey in Central, Copperbelt and Lusaka provinces. Participants 1484 women of reproductive age (15–44 years). Primary and secondary outcome measures Correct knowledge of the legal grounds for abortion, att... περισσότερα »
Comparative analysis of premature mortality among urban immigrants in Bremen, Germany: a retrospective register-based linkage study
Objectives The main objective of this study was to explore differences in mortality patterns among two large immigrant groups in Germany: one from Turkey and the other from the former Soviet Union (FSU). To this end, we investigated indicators of premature mortality. Design This study was conducted as a retrospective population-based study based on mortality register linkage. Using mortality data for the period 2004–2010, we calculated age-standardised death rates (SDR) and standardised mortality ratios (SMR) for premature deaths (<age 65 years). We computed years of potential ...περισσότερα »
Perceptions and impact of plain packaging of tobacco products in low and middle income countries, middle to upper income countries and low-income settings in high-income countries: a systematic review of the literature
Objective To review the current literature around the potential impact, effectiveness and perceptions of plain packaging in low income settings. Method A systematic review of the literature. Data sources 9 databases (PubMed, Global Health, Social Policy and Practice, Applied Social Sciences Index and Abstracts (ASSIA), CINAHL, PsycINFO, British Library for Development Studies (BLDS), Global Health Library and Scopus) were searched. The terms used for searching combined terms for smoking and tobacco use with terms for plain packaging. Study selection Studies investigating the ...περισσότερα »
HESX1 Mutations in Patients with Congenital Hypopituitarism: Variable Phenotypes with the Same Genotype
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Introduction Mutations in the transcription factor HESX1 can cause Isolated Growth Hormone Deficiency (IGHD) or Combined Pituitary Hormone Deficiency (CPHD) with or without Septo-Optic Dysplasia (SOD). So far there is no clear genotype-phenotype correlation. Patients and Results We report three different recessive loss-of-function mutations in three unrelated families with CPHD and no midline defects […]
Suppression of WHITE COLLAR-independent frequency Transcription by Histone H3 Lysine 36 Methyltransferase SET-2 Is Necessary for Clock Function in Neurospora DNA and Chromosomes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The circadian system in Neurospora is based on the transcriptional/translational feedback loops and rhythmic frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Our previous paper has shown that frq could be transcribed in a WC-independent pathway in a strain lacking the histone H3K36 methyltransferase, SET-2 (su(var)3-9-enhancer-of-zeste-trithorax-2) (1), but the mechanism was unclear. Here we […]
The Nuclear Receptor Rev-erb{alpha} Regulates Adipose Tissue-Specific Fibroblast Growth Factor 21 (FGF21) Signaling Gene Regulation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Fibroblast growth factor-21 (FGF21) is an atypical member of the FGF family that functions as a hormone to regulate carbohydrate and lipid metabolism. Here we demonstrate that the actions of FGF21 in mouse adipose tissue, but not in liver, are modulated by the nuclear receptor Rev-erbα, a potent transcriptional repressor. Interrogation of genes induced in […]
Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X domain Molecular Biophysics
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Although most proteins fold by populating intermediates, the transient nature of such states makes it difficult to characterise their structures. In this work we identified and characterised the structure of an intermediate of the X domain of phosphoprotein P of measles virus. We obtained this result by a combination of equilibrium and kinetic measurements, and […]
Upregulation of histone methyltransferase, DOT1L by matrix hyaluronan promotes MicroRNA-10 expression leading to tumor cell invasion and chemoresistance in cancer stem cells from head and neck squamous cell carcinoma Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Human Head and Neck Squamous Cell Carcinoma (HNSCC) is a solid tumor malignancy associated with major morbidity and mortality. In this study we determined that human HNSCC-derived HSC-3 cells contain a subpopulation of cancer stem cells (CSCs) characterized by a high level of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression. Importantly, matrix hyaluronan (HA) induces the […]
Leptin resistance contributes to obesity in mice with null mutation of carcinoembryonic antigen cell adhesion molecule 1 Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance. Consistently, mice with null mutation of Ceacam1 (Cc1-/-) exhibit impaired insulin clearance with increased lipid production in liver and redistribution to white adipose tissue, leading to visceral obesity at 2 months of age. When the mutation is propagated on the C57/BL6J genetic background, total […]
Human Cells Cultured Under Physiological Oxygen Utilize Two Cap-binding Proteins to Recruit Distinct mRNAs for Translation Cell Biology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Translation initiation is a focal point of translational control and requires the binding of eukaryotic initiation factor 4E (eIF4E) to the 5′ cap of mRNA. Under conditions of extreme oxygen depletion (hypoxia), human cells repress eIF4E and switch to an alternative cap-dependent translation mediated by a homologue of eIF4E, eIF4E2. This homologue forms a complex […]
Enhancing NAD+salvage pathway reverts the toxicity of primary astrocytes expressing amyotrophic lateral sclerosis-linked mutant SOD1 Neurobiology
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling pathways. While the redox reactions are critical for efficient mitochondrial metabolism, they are not accompanied by any net consumption of the nucleotide. On the contrary, NAD+-dependent signaling processes lead to its degradation. Three distinct families of enzymes consume NAD+ as substrate: Poly(ADP-ribose) polymerases (PARPs), […]
Translation control of swarming proficiency in Bacillus subtilis by 5-amino-pentanolylated elongation factor P Protein Synthesis and Degradation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Elongation factor P (EF-P) accelerates diprolyl synthesis and requires a posttranslational modification (PTM) to maintain proteostasis. Two phylogenetically distinct EF-P modification pathways have been described and are encoded in the majority of Gram-negative bacteria, but neither is present in Gram-positive bacteria. Prior work suggested the EF-P encoding gene (efp) primarily supports Bacillus subtilis swarming differentiation, […]
Scabin, a novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies Molecular Biophysics
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A bioinformatics strategy was used to identify Scabin, a novel DNA-targeting enzyme from the plant pathogen 87.22 strain of Streptomyces scabies. Scabin shares nearly 40% sequence identity with the Pierisin family of mono-ADP-ribosyltransferase toxins. Scabin was purified to homogeneity as a 22-kDa single-domain enzyme and was shown to possess high NAD+-glycohydrolase (KM(NAD) = 68 ± […]
Do Supplements Help or Harm CLL Patients?
For people with CLL, are supplements safe? Could they help fight CLL? In this segment, Patient Power founder Andrew Schorr poses these questions to an expert panel, including Drs. Michael Keating, Nic… Author: patientpower Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcw5jG via IFTTT
Highlights from the American Society of Hematology 2015 Annual Meeting
Ruben A. Mesa, MD from Mayo Clinic, Scottsdale, AZ, summarizes highlights from the American Society of Hematology (ASH) 2015 Annual Meeting, held in Orlando, FL. He points out that we continue to lear… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22BfkTc via IFTTT
The challenges patient groups face and how they help patients
Giora Sharf, Founder of Flute of Light and Co-Founder of CML Advocates Network, talks about why patient groups should work together with the pharma industry on drug development and other areas of rese… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcw5jA via IFTTT
The CML Advocates Network
Giora Sharf, Founder of Flute of Light and Co-Founder of CML Advocates Network, talks about how the CML Advocates Network has grown since it started in 2007. He also discusses the CML Advocates Networ… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22BfkSY via IFTTT
Flute of Light, a charity for blood cancer patients in Israel
Giora Sharf, Founder of Flute of Light and Co-Founder of CML Advocates Network, talks about the new charity Flute of Life for blood cancer patients in Israel. The charity will provide help and assista… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcw2Ew via IFTTT
Idelalisib plus bendamustine and rituximab improves the outcome of relapsed/refractory CLL
Andrew Zelenetz, MD, PhD from the Memorial Sloan-Kettering Cancer Center, New York, NY gives a brief overview of relapsed/refractory chronic lymphocytic leukemia (CLL) and describes the results of a P… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22BfiKZ via IFTTT
The next challenge for multiple myeloma research
Sagar Lonial, MD from Emory University Winship Cancer Institute, Atlanta, GA gives a brief overview of the next challenge that lies ahead for multiple myeloma research in the next two years. He descri… Author: PatientPowerEU Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcw2o4 via IFTTT
Immunotherapy for head and neck cancer
At the German Cancer Congress 2016, held in Berlin, Germany from 24 to 27 February 2016, Viktor Grünwald, MD, PhD, from Hannover Medical School, Hannover, Germany, highlights recent advances in the tr… Author: EMJ Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22BfiKQ via IFTTT
Understanding the unique aspects of immunotherapy for lung cancer
At the German Cancer Congress 2016, held in Berlin, Germany, from 24 to 27 February 2016, Martin Reck, MD, PhD, from the LungenClinic Grosshansdorf, Grosshansdorf, Germany, discusses the efficacy and … Author: EMJ Added: 03/21/2016 (Source: Oncology Tube) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Rcw2nY via IFTTT
miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer
Conclusions: miR-503 acts as an ‘onco-miR’ in CRC. High miR-503 expression is associated with early recurrence and poor prognosis in CRC.Oncology 2016;90:43-53 (Source: Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22BfklW via IFTTT
The new standard for HEMS safety in marginal WX:
PROuD project: H135 to improve safety for EMS operations in Norway. In Norway, around 700 flights each year cannot be flown due to bad weather and poor visibility. This is about to change with the introduction of new navigational instruments and flight procedures that use satellite-based GPS technology. Norwegian Air Ambulance: HEMS trained Anesthesist and HEMS-Tec. / Rescue personell. Long-rope, Water rescue. All crews have Responscar, for use near base / "No flight" weather. (Europe`s largest research environment on EMS -More then 20 projects going.) (Research unit have their own E...περισσότερα »
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article Primary cilia are highly conserved microtubule-based organelles that play essential roles in several cellular processes including osteogenesis. Here the authors show that intraflagellar protein IFT80 regulates osteoblast differentiation by balancing signalling though the canonical and non-canonical Hedgehog pathways. Nature Communications doi: 10.1038/ncomms11024 Authors: Xue Yuan, Jay Cao, Xiaoning He, Rosa Serra, Jun Qu, Xu […]
Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Article The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al. identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE. Nature Communications doi: 10.1038/ncomms10962 Authors: Yi Lu, Cheng Zhong, Lulu […]
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