Oncolytic adenoviruses targeted to Human Papilloma Virus-positive head and neck squamous cell carcinomas
Publication date: May 2016 *Source:*Oral Oncology, Volume 56 Author(s): Christopher J. LaRocca, Joohee Han, Amanda O. Salzwedel, Julia Davydova, Mark C. Herzberg, Rajaram Gopalakrishnan, Masato Yamamoto ObjectivesIn recent years, the incidence of Human Papilloma Virus (HPV)-positive head and neck squamous cell carcinomas (HNSCC) has markedly increased. Our aim was to design a novel therapeutic agent through the use of conditionally replicative adenoviruses (CRAds) that are targeted to the HPV E6 and E7 oncoproteins.MethodsEach adenovirus included small deletion(s) in the E1a region ... περισσότερα »
Cytokines in primary Sjögren's syndrome (pSS)
Cytokine-induced STAT1 activation is increased in patients with primary Sjögren's syndrome via Clinical Immunology Publication date: Available online 17 March 2016 *Source:*Clinical Immunology Author(s): Marja Pertovaara, Olli Silvennoinen, Pia Isomäki Limited data are available regarding the intracellular responses to different cytokines in primary Sjögren's syndrome (pSS). We studied the signal transducer and activator of transcription (STAT) activation profile in response to cytokine stimulations in peripheral blood mononuclear cells (PBMCs) from pSS patients by multicolor flow cyto... περισσότερα »
Alloantibody-Mediated Cytotoxicity
Quantification of Alloantibody-Mediated Cytotoxicity In Vivo.: Background: Preexisting, donor-specific antibodies (DSAs) are culprits of hyperacute rejection. Donor-specific antibodies are also formed de novo, and their role in acute and chronic rejection is increasingly appreciated. However, it is difficult to assess damage inflicted exclusively by DSAs when alloreactive T cell and B cell responses coincide. We reasoned that allosensitization with "costimulation-deficient" cells should induce DSA synthesis but not naive cytotoxic T lymphocyte (CTL) precursors' priming via direct al... περισσότερα »
Low-dose polymyxin: an option for therapy of Gram-negative sepsis
Low-dose polymyxin: an option for therapy of Gram-negative sepsis: Endotoxins are the major components of the outer membrane of most Gram-negative bacteria and are one of the main targets in inflammatory diseases. The presence of endotoxins in blood can provoke septic shock in case of pronounced immune response. Here we show *in vitro* inactivation of endotoxins by polymyxin B (PMB). The inflammatory activity of the LPS–PMB complex in blood was examined *in vitro* in freshly drawn blood samples. Plasma protein binding of PMB was determined by ultracentrifugation using membranes wit... περισσότερα »
Chronic inducible urticarias
The definition, diagnostic testing and management of chronic inducible urticarias – update and revision of the EAACI/GA2LEN/EDF/UNEV 2009 consensus panel recommendations: [image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (1), a joint initiative of the EAACI (European Academy of Allergology and Clinical Immunology) Dermatology Section, the GA2LEN (Global Allergy a... περισσότερα »
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors: Abstract ObjectivesPatients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas (OPSCCs) have an improved prognosis compared to HPV-negative OPSCCs. Several theories have been proposed to explain this relatively good prognosis. One hypothesis is a difference in immune response. In this study, we compared tumor-infiltrating CD3+, CD4+, CD8+ T-cells, and granzyme inhibitors (SERPINB1, SERPINB4, and SERPINB9) between HPV-positive and HPV-negative tumors and the relation with... περισσότερα »
Chylous Fistula after sentinel lymph biopsy
Chylous Fistula after sentinel lymph biopsy: Chyle leaks or fistulas are a well described complication of neck dissection or mediastinal surgeries. The thoracic duct or the right lymphatic duct are the main structures disrupted. There are lesser described subclavian lymphatic ducts that drain the lymph from the axillae and upper extremities bilaterally. Rarely these may be disrupted during axillary lymph node dissection that could lead to a chyle leak.
The free scapular flap with latissimus muscle reduces fistulas in mandibular reconstruction
The free scapular flap with latissimus muscle reduces fistulas in mandibular reconstruction via British Association of Plastic Surgeons Publication date: Available online 16 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Tommy Wilkman, Jyrki Törnwall, Jyrki Vuola, Patrik Lassus IntroductionThe free scapular chimeric flap is a less common choice for facial reconstruction. Our aim in this study was to evaluate the versatility and safety of the flap, the procedure for a two-team approach, the safety of the osteotomies, and the possibility of dental im... περισσότερα »
Aesthetic and Functional Rhinoplasty: The RHINO Scale
A Comprehensive Quality-of-Life Instrument for Aesthetic and Functional Rhinoplasty: The RHINO Scale: [image: image] Background: Currently, there is no validated quality-of-life instrument that evaluates both functional and aesthetic outcomes after rhinoplasty. The goal of this study was to develop and validate a comprehensive quality-of-life instrument to assess patient satisfaction with both functional and aesthetic outcomes after rhinoplasty. Methods: The study was designed as a prospective instrument validation study at a university-affiliated academic medical center. Inclusion... περισσότερα »
The Pedicled Hypothenar Perforator Flap
“: Indications and Clinical Application“ via British Association of Plastic Surgeons Publication date: Available online 16 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Stefan Winsauer, Alexander Gardetto, Peter Kompatscher BackgroundSoft-tissue defects of the palm and the palmar aspect of the fifth finger are a constant problem in reconstructive hand surgery. We present a possible approach to planning and harvesting of pedicled hypothenar perforator flaps for the reconstruction of such defects.MethodsA hypothenar perforator flap was used to recon...περισσότερα »
Total auricular reconstruction using prelamination of extended retroauricular flap with tissue expansion
A new strategy for via British Association of Plastic Surgeons Publication date: Available online 16 March 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Chuan Li, Haiyue Jiang, Chenyu Huang, Jingning Chen, Rongwei Wu, Ye Bi, Meirong Yang, Ye Zhang, Bo Pan BackgroundTo accomplish total ear reconstruction with aesthetic appearance is a great challenge for plastic surgeons worldwide due to insufficient skin coverage. A retroauricular fascia flap and skin graft technique are commonly used, but the results are unsatisfied due to color mismatch, severe edem... περισσότερα »
Efferent Lymphatic Vessel Anastomosis: Supermicrosurgical Efferent Lymphatic Vessel-to-Venous Anastomosis for the Prophylactic Treatment of Subclinical Lymphedema
Efferent Lymphatic Vessel Anastomosis: Supermicrosurgical Efferent Lymphatic Vessel-to-Venous Anastomosis for the Prophylactic Treatment of Subclinical Lymphedema: Background: In lower extremity lymphedema secondary to pelvic cancer treatments, lymphedema develops despite that the inguinal lymph nodes (LNs) are preserved. Obstruction of the efferent lymphatic vessels of the inguinal LNs causes lower extremity lymphedema, and it is considered a radical treatment to bypass the efferent lymphatic vessel. Methods: Efferent lymphatic vessel anastomosis, supermicrosurgical efferent lympha... περισσότερα »
A Secure Technique for Microvascular Anastomosis in Arteries with Intimal Dissection: Intimal Sleeve Fold-Over Technique
A Secure Technique for Microvascular Anastomosis in Arteries with Intimal Dissection: Intimal Sleeve Fold-Over Technique: Background: Intimal dissection can cause an irregular internal surface with intimal flaps and subendothelial collagen exposure. This has been associated with a high risk of thrombosis. Trimming the artery to a healthy level is routinely recommended to avoid intimal dissection. However, this method is limited when there is inadequate vascular length to work with. Methods: We dealt with an artery exhibiting severe intimal dissection by using a new suture technique:... περισσότερα »
Asymptomatic Deep Peroneal Vein Thrombosis During Free Fibula Flap Harvest: A Review of the Literature, Strategies for Preoperative Assessment, and an Algorithm for Reconstruction
Asymptomatic Deep Peroneal Vein Thrombosis During Free Fibula Flap Harvest: A Review of the Literature, Strategies for Preoperative Assessment, and an Algorithm for Reconstruction: [image: image] Abstract: The free fibula flap is the preferred reconstructive method for oncologic defects of the mandible. Arterial inflow of the extremity is routinely evaluated with several modalities; however, venous screening is rarely performed. Patients with cancer are at elevated risk of occult deep venous thrombosis (DVT). An asymptomatic thrombus encountered during free fibula reconstruction is... περισσότερα »
Surgical Navigation Systems in Complex Craniomaxillofacial Surgery: The Use of Multisurface 3-Dimensional Images and a 2-Plane Reference System
Clinical Application of Different Surgical Navigation Systems in Complex Craniomaxillofacial Surgery: The Use of Multisurface 3-Dimensional Images and a 2-Plane Reference System: Background: Intraoperative navigation is a tool that provides surgeons with real-time guidance based on patients’ preoperative imaging studies. The application of intraoperative navigation to neurosurgery and otolaryngology has been well documented; however, only isolated reports have analyzed its potential in the field of craniomaxillofacial surgery. Methods: From November 2010 to July 2014, 15 patients we...περισσότερα »
Bartsocas-Papas Syndrome: Severe growth retardation, midface hypoplasia, popliteal pterygia, and syndactyly
Bartsocas-Papas Syndrome: A Case Report and Review of the Literature: Abstract: Bartsocas-Papas syndrome (BPS) is an autosomal recessively inherited form of the popliteal pterygium syndrome characterized by severe growth retardation, midface hypoplasia, popliteal pterygia, and syndactyly. Almost all affected babies die in utero or infancy. We report the difficulties of reconstruction and ongoing plastic surgical management in an 8-year-old child with BPS. With increasingly sophisticated resuscitation and supportive techniques, it is possible that more patients with BPS will survive... περισσότερα »
Effects of Cleft Width and Veau Type on Incidence of Palatal Fistula and Velopharyngeal Insufficiency After Cleft Palate Repair
Effects of Cleft Width and Veau Type on Incidence of Palatal Fistula and Velopharyngeal Insufficiency After Cleft Palate Repair: Background: Postoperative fistulae and velopharyngeal insufficiency (VPI) are 2 important complications after cleft palate repair. The effects of preoperative cleft width on outcomes after cleft palate repair have been rarely studied. Methods: A retrospective review of all patients undergoing primary cleft palatoplasty by a single surgeon between 2004 and 2011 was performed. Primary outcomes were palatal fistula and VPI, defined as the need for corrective... περισσότερα »
Conditioned Media From Adipose-Derived Stromal Cells Accelerates Healing in 3-Dimensional Skin Cultures
Conditioned Media From Adipose-Derived Stromal Cells Accelerates Healing in 3-Dimensional Skin Cultures: Abstract: Wound healing involves a number of factors that results in the production of a “closed” wound. Studies have shown, in animal models, acceleration of wound healing with the addition of adipose-derived stromal cells (ADSC). The cause for the positive effect which these cells have on wound healing has not been elucidated. We have previously shown that addition of ADSC to the dermal equivalent in 3-dimensional skin cultures accelerates reepithelialization. We now demonstrat...περισσότερα »
Practical Repair Method for Unilateral Cleft Lips: Straight-Line Advanced Release Technique
Practical Repair Method for Unilateral Cleft Lips: Straight-Line Advanced Release Technique: Background: Straight-line closure repair of unilateral cleft lips was first introduced in the 1840s, and since then, many different techniques have been attempted for cleft repair. However, these methods have several disadvantages and are difficult to adopt. In this study, we describe our novel technique, known as Straight-Line Advanced Release Technique (StART), and its application in treating several cases of unilateral cleft lip. Methods: The preoperative design of the surgical method is ... περισσότερα »
An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty Over Scarred Dura
An Experimental Study of Particulate Bone Graft for Secondary Inlay Cranioplasty Over Scarred Dura: Background: Inlay cranioplasty in children is challenging because autologous bone is limited. Cranial particulate bone graft effectively closes defects when placed over normal dura. The purpose of this study was to determine if particulate bone graft will ossify when used for secondary cranioplasty over scarred dura. Methods: A 17 × 17-mm critical-sized defect was made in the parietal bone of 16 rabbits. Four animals had no implant (group 1). Twelve animals had the defect remade 16 we... περισσότερα »
Exposure to Varying Strain Magnitudes Influences the Conversion of Normal Skin Fibroblasts Into Hypertrophic Scar Cells
Exposure to Varying Strain Magnitudes Influences the Conversion of Normal Skin Fibroblasts Into Hypertrophic Scar Cells: Abstract: Mechanical strain is a key contributor in the pathogenesis of hypertrophic scarring, whose optimal stretch magnitudes to initiate the differentiation of normal skin fibroblasts into aberrant fibroblasts phenotype remains largely unresolved. Influence of varying cyclic strain magnitudes on cultured human normal skin fibroblasts and its transformation into hypertrophic scar fibroblast–like phenotype is investigated in this study. Cultured fibroblasts isolat... περισσότερα »
When the Gastrointestinal Conduit for Total Esophageal Reconstruction Is Not an Option: Review of the Role of Skin Flaps and Report of Salvage With a Single-Stage Tubed Anterolateral Thigh Flap
When the Gastrointestinal Conduit for Total Esophageal Reconstruction Is Not an Option: Review of the Role of Skin Flaps and Report of Salvage With a Single-Stage Tubed Anterolateral Thigh Flap: Abstract: This review adds to the limited body of literature describing the use of skin flaps for reconstruction of the esophagus and includes a report of a successful 1-stage, intrathoracic reconstruction of the cervical and thoracic esophagus after failed gastrointestinal conduit. Already widely used for reconstruction of the pharynx and cervical esophagus, the versatile anterolateral thig... περισσότερα »
Prevention of Lymphedematous Change by Nonvascularized Lymph Node Transplantation
Prevention of Lymphedematous Change in the Mouse Hindlimb by Nonvascularized Lymph Node Transplantation: [image: image]Abstract: Lymphedema is a condition characterized by progressive swelling and adipose deposition that occurs commonly after lymphadenectomy. Recent clinical studies have suggested that the transfer of lymph nodes to the lymphedematous limb can improve lymphatic function. In this report, we investigate dynamic modulation of lymphatic flow and the microscopic changes of lymphatic regeneration using a lymphedema mouse model that was treated with nonvascularized lymph n... περισσότερα »
Fat Grafting for Recontouring Sunken Upper Eyelids With Multiple Folds in Asians—Novel Mechanism for Neoformation of Double Eyelid Crease
Fat Grafting for Recontouring Sunken Upper Eyelids With Multiple Folds in Asians—Novel Mechanism for Neoformation of Double Eyelid Crease: [image: image]Background: This study reviewed the mini invasive technique, microautologous fat transplantation (MAFT), as a strategy in simultaneously treating sunken upper eyelids with multiple folds and recreating a double eyelid crease in Asian people. Methods: The MAFT was performed with the assistance of a patented medical device, the MAFT-GUN, on 34 patients who had sunken upper eyelids and multiple folds. Each delivered fat parcel was ac...περισσότερα »
Dorsal Intercostal Artery Perforator Propeller Flaps in Reconstruction of Large Meningomyelocele Defects
Dorsal Intercostal Artery Perforator Propeller Flaps: A Reliable Option in Reconstruction of Large Meningomyelocele Defects: Abstract: Several options have been reported for the reconstruction of myelomeningocele defects. In this article, we present our experience on soft tissue reconstruction of myelomeningocele defects by using island propeller dorsal intercostal artery perforator (DIAP) flaps. Between January 2008 and February 2014, all newborns with large myelomeningocele defects (13 newborns) were reconstructed with island propeller DIAP flaps. All flaps survived completely. In... περισσότερα »
Transposed Corrugator Supercilii Muscle–Tendon Unit Flap
Transposed Corrugator Supercilii Muscle–Tendon Unit Flap: [image: s_qld160002f1.png] This cadaver study assesses the feasibility of a transposed flap consisting of the corrugator supercilii muscle–tendon unit to repair a paralyzed medial ectropion. This cadaver study assesses the feasibility of a transposed flap consisting of the corrugator supercilii muscle–tendon unit to repair a paralyzed medial ectropion. In facial paralysis, denervation of the orbicularis oculi muscle (OOM) may result in loss of lower eyelid support and paralytic ectropion. Surgical repair of ectropion aim... περισσότερα »
Effect of Lateral Crural Repositioning on Alar Rim Position
Effect of Lateral Crural Repositioning on Alar Rim Position: This case series found that in patients who underwent lower lateral crural repositioning, the alar rim was significantly lowered, and the addition of adjunctive grafts did not add significantly to the rim-lowering effect. *Importance* Cephalically malpositioned lateral crura are a frequent cause of alar rim retraction during both primary and revision rhinoplasty. *Objective* To demonstrate the efficacy of lateral crural repositioning as an isolated maneuver as and combined with adjunctive grafts for lowering the alar r... περισσότερα »
FACE-Q to Measure QOL After Aesthetic Facial Treatments
FACE-Q to Measure QOL After Aesthetic Facial Treatments: [image: qle160001.pdf.gif] *To the Editor* We commend Jacono and colleagues for using a patient-reported outcome measure (PROM) in their study, adding to the body of evidence-based outcomes data for facial aesthetics treatments. We have concerns, though, about their choice of PROM. The Rosenberg Self-Esteem scale (RSES) is a legacy scale, published in 1965 after testing in more than 5000 US high school students. Jacono and colleagues found no change in self-esteem in 50 patients 6 months after a face-lift. This was not a ... περισσότερα »
Model Formation of the Inverted-V Deformity
Model Formation of the Inverted-V Deformity: This study models use of the finite element method to simulate the formation of the inverted-V deformity after separation of the upper lateral cartilages forming the nasal septum during rhinoplasty. *Importance* Computational modeling can be used to mimic the forces acting on the nasal framework that lead to the inverted-V deformity (IVD) after surgery and potentially determine long-range outcomes. *Objective* To demonstrate the use of the finite element method (FEM) to predict the formation of the IVD after separation of the upper la... περισσότερα »
Definitive Cleft Rhinoplasty for Unilateral Cleft Nasal Deformity
Definitive Cleft Rhinoplasty for Unilateral Cleft Nasal Deformity: [image: s_qpe150010f1.png] This surgical technique describes cleft rhinoplasty for long-lasting nasal symmetry and breathing improvement. This surgical technique describes cleft rhinoplasty for long-lasting nasal symmetry and breathing improvement. Definitive cleft rhinoplasty is a challenging operation performed after completion of nasal growth, with the goal of long-lasting improvement in nasal symmetry and breathing.1- 4 This procedure is intended to be the final surgery for patients with cleft lip and pala... περισσότερα »
Transposed Corrugator Supercilii Muscle–Tendon Unit Flap
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 17 δευτερόλεπτα
Transposed Corrugator Supercilii Muscle–Tendon Unit Flap: [image: s_qld160002f1.png] This cadaver study assesses the feasibility of a transposed flap consisting of the corrugator supercilii muscle–tendon unit to repair a paralyzed medial ectropion. This cadaver study assesses the feasibility of a transposed flap consisting of the corrugator supercilii muscle–tendon unit to repair a paralyzed medial ectropion. In facial paralysis, denervation of the orbicularis oculi muscle (OOM) may result in loss of lower eyelid support and paralytic ectropion. Surgical repair of ectropion aim... περισσότερα »
Journal of the Association for Research in Otolaryngology, Vol. 17, Issue 2 - New Issue Alert
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 19 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/18/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Journal of the Association for Research in Otolaryngology*. Volume 17 Number 2 is now available online. In this issue Research Article Increased Spontaneous Otoacoustic Emissions in Mice with a Detached Tectorial Membrane Mary Ann Cheatham, Aisha Ahmad, Yingjie Zhou, Richard J. Goodyear, Peter Dallos & Guy P. Richardson » Abstract » Full text HTML ... περισσότερα »
Nasal Valve Obstruction After Rhinoplasty
Nasal Valve Obstruction After Rhinoplasty: This multicenter cohort study compares improvement in nasal obstruction symptoms in patients undergoing functional and aesthetic-functional rhinoplasty. *Introduction* Nasal valve insufficiency is distinct from other anatomic causes of nasal obstruction. Functional rhinoplasty refers to the collective techniques used to reconstruct the lateral nasal wall, typically achieved with the use of spreader and alar grafts. Patients undergoing functional rhinoplasty can also have aesthetic desires and goals achievable with combined aesthetic-fun... περισσότερα »
Oncolytic adenoviruses targeted to Human Papilloma Virus-positive head and neck squamous cell carcinomas
Oncolytic adenoviruses targeted to Human Papilloma Virus-positive head and neck squamous cell carcinomas via ScienceDirect Publication: Oral Oncology Publication date: May 2016 *Source:*Oral Oncology, Volume 56 Author(s): Christopher J. LaRocca, Joohee Han, Amanda O. Salzwedel, Julia Davydova, Mark C. Herzberg, Rajaram Gopalakrishnan, Masato Yamamoto ObjectivesIn recent years, the incidence of Human Papilloma Virus (HPV)-positive head and neck squamous cell carcinomas (HNSCC) has markedly increased. Our aim was to design a novel therapeutic agent through the use of conditionally replic... περισσότερα »
Osteotomy vs Augmentation Genioplasty
Osteotomy vs Augmentation Genioplasty: [image: qic150016.pdf.gif] Patients seeking improved lower facial esthetics through genioplasty are often confronted with the options of bony advancement osteotomy vs implant augmentation. The choice of one of these options vs the other is often based on surgical experience and training rather than evidence-based data. Implant surgery is less invasive and reversible but carries the risks of underlying bony resorption and hardware infection. Osteotomy is more versatile and long lasting and can provide functional improvements, if the genial ... περισσότερα »
Prehospital Ultrasound: Emerging technology for EMS
Prehospital Ultrasound: Emerging technology for EMS: Prehospital ultrasound is a form of medical imaging that is portable, non-invasive, painless, and does not expose the patient to ionizing radiation. With proper training and education, prehospital providers can use ultrasound to obtain immediate anatomical, diagnostic, and functional information on their patients [1]. In recent years, ultrasound devices have decreased in size and cost while producing images of enhanced quality. The recent advances in bedside devices have made ultrasound more accessible to prehospital providers wi... περισσότερα »
Acquired torticollis due to primary pyomyositis of the paraspinal muscles in an 11-year-old boy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Torticollis is characterised by tilting and rotation of the cervical spine in opposite directions. Causes can be congenital or acquired. Primary pyomyositis is a rare subacute deep bacterial infection of skeletal muscles that typically affects individuals under 20 years of age from tropical countries. Infrequently, pyomyositis occurs in individuals from temperate regions, usually in immunocompromised […]
Cardiac resynchronisation therapy in the presence of left-to-right intracardiac shunting: more good than harm?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
An elderly Chinese man with moderately impaired left ventricular function, left bundle branch block and ST-elevation myocardial infarction complicated by ventricular septal rupture had class IV heart failure symptoms refractory to medical and surgical interventions. As a treatment of last resort, a cardiac resynchronisation therapy (CRT) pacemaker was implanted apprehensively, as preoperative concerns were raised […]
Ebstein’s anomaly of tricuspid valve with rheumatic mitral stenosis: a rare association
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Description A 16-year-old girl presented with progressive exertional dyspnoea and palpitations of 3-year duration. The medical history revealed one episode of fever with migratory polyarthritis at the age of 7 years, but it was not further evaluated. On presentation, she was in sinus rhythm with a pulse rate of 88/min and blood pressure of 110/80 […]
Painless acute myocardial infarction on Mount Kilimanjaro
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
An individual experiencing dyspnoea or syncope at high altitude is commonly diagnosed to have high-altitude pulmonary edema or cerebral edema. Acute myocardial infarction (AMI) is generally not considered in the differential diagnosis. There have been very rare cases of AMI reported only from Mount Everest. We report a case of painless ST segment elevation myocardial […]
Ebstein’s anomaly of tricuspid valve with rheumatic mitral stenosis: a rare association
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Description A 16-year-old girl presented with progressive exertional dyspnoea and palpitations of 3-year duration. The medical history revealed one episode of fever with migratory polyarthritis at the age of 7 years, but it was not further evaluated. On presentation, she was in sinus rhythm with a pulse rate of 88/min and blood pressure of 110/80 […]
Painless acute myocardial infarction on Mount Kilimanjaro
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
An individual experiencing dyspnoea or syncope at high altitude is commonly diagnosed to have high-altitude pulmonary edema or cerebral edema. Acute myocardial infarction (AMI) is generally not considered in the differential diagnosis. There have been very rare cases of AMI reported only from Mount Everest. We report a case of painless ST segment elevation myocardial […]
Renal tubular acidosis type 4 in pregnancy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published. Renal tubular acidosis type 4 is a condition associated with increased urinary ammonia secondary to hypoaldosteronism or pseudohypoaldosteronism. Pregnancy may worsen the hyperkalaemia and acidosis of renal tubular acidosis type 4, possibly through an antialdosterone […]
Is size really a contraindication for laparoscopic resection of giant adrenal myelolipomas?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
A 55-year-old non-diabetic, normotensive man presented with dull aching pain in the left upper abdomen of 2-year duration. He had no significant medical, surgical or family history. Relevant blood tests and chest skiagram were normal. 24 h urinary vanillylmandelic acid levels and serum electrolyte levels were normal. Ultrasonogram and CT findings were suggestive of a […]
A cautionary approach to adult female groin swelling: hydrocoele of the canal of Nuck with a review of the literature
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Hydrocoele of the canal of Nuck in an adult female is a rare entity and analogous to hydrocoele in males. Its usual presentation is in children, and its occurrence in adults is very uncommon, more so of the hour-glass variety. We report a case of a 38-year-old woman presenting with a right inguinal swelling of […]
Isolated subglossopalatal membrane: a rare entity to encounter
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα
Description Subglossopalatal membrane is a fibrous connection extending from the floor of the mouth to the palate. There are case reports of this condition being associated with other congenital anomalies and syndromes.12 However, isolated subglossopalatal membrane has never been reported in the literature. Earlier, it was believed to be a surgical emergency; however, a recent […]
Higher rate alternative non-drug reinforcement produces faster suppression of cocaine seeking but more resurgence when removed
[image: alertIcon.gif] Publication date: 1 June 2016 *Source:*Behavioural Brain Research, Volume 306 Author(s): Andrew R. Craig, Rusty W. Nall, Gregory J. Madden, Timothy A. Shahan Relapse following removal of an alternative source of reinforcement introduced during extinction of a target behavior is called resurgence. This form of relapse may be related to relapse of drug taking following loss of alternative non-drug reinforcement in human populations. Laboratory investigations of factors mediating resurgence with food-maintained behavior suggest higher rates of alternative reinfor... περισσότερα »
The definition, diagnostic testing and management of chronic inducible urticarias – update and revision of the EAACI/GA2LEN/EDF/UNEV 2009 consensus panel recommendations
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 50 δευτερόλεπτα
Abstract These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (1), a joint initiative of the EAACI (European Academy of Allergology and Clinical Immunology) Dermatology Section, the GA2LEN (Global Allergy and Asthma European Network) task force on […]
TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells
Abstract The intracellular cysteine protease caspase-1 is critically involved in obesity-induced inflammation in adipose tissue. A substantial body of evidence from immune cells, such as macrophages, has shown that caspase-1 activation depends largely on a protein complex, called the NLRP3 inflammasome, which consists of the NOD-like receptor (NLR) family protein NLRP3, the adaptor protein ASC, and caspase-1 itself. However, it is not fully understood how caspase-1 activation is regulated within adipocytes upon inflammatory stimuli. In this study, we show that TNF-α-induced activa...περισσότερα »
Spontaneous rupture of an intrahepatic aneurysm of the right hepatic artery caused by segmental arterial mediolysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Segmental arterial mediolysis (SAM) is a non-arteriosclerotic, non-inflammatory arteriopathy characterised by dissecting aneurysms and most commonly found in abdominal arteries. A rupture of a visceral artery aneurysm is generally associated with high mortality. We present the case of a 57-year-old woman with a rupture of an intrahepatic aneurysm that led to intra-abdominal haemorrhage. The patient […]
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Most cases of insulinomas are benign. We report a case of a malignant form of insulinoma. A 46-year-old man presented with behavioural changes associated with hypoglycaemia. Diagnostic work up revealed high serum insulin, high C-peptide and low glucose levels, compatible with endogenous hyperinsulinaemic hypoglycaemia. CT imaging of the abdomen revealed a pancreatic head mass and […]
Dawn of a new era: the completely interventionally treated patient
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
A frail 75-year-old woman with permanent atrial fibrillation and angina pectoris was admitted to our department for further evaluation. Echocardiography revealed concurrent severe aortic valve stenosis. Furthermore, significant coronary artery stenoses were identified on the coronary angiogram. We chose the following treatment strategy: first, two drug eluting stents were implanted successfully in the left anterior […]
Diffuse large B-cell lymphoma of the adrenal gland: a rare cause of primary adrenal insufficiency
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Although it is a rare entity, primary lymphoma of the adrenal gland should be considered in the differential diagnosis of bilateral nodular adrenal lesions, particularly when there is evidence of associated adrenal insufficiency. We describe the case of an 83-year-old woman admitted to the emergency department due to a month’s history of asthenia, weight loss, […]
Anterior spinal fixation for recollapse of cemented vertebrae after percutaneous vertebroplasty
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Although recollapse after percutaneous vertebroplasty (PV) is a serious complication that needs salvage surgery, there is no consensus regarding the best operative treatment for this failure. We present cases of 3 patients, diagnosed as having thoracic osteoporotic vertebral fractures, who had undergone PV at other institutes. Within less than half a year, recollapse occurred at […]
Acquired torticollis due to primary pyomyositis of the paraspinal muscles in an 11-year-old boy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Torticollis is characterised by tilting and rotation of the cervical spine in opposite directions. Causes can be congenital or acquired. Primary pyomyositis is a rare subacute deep bacterial infection of skeletal muscles that typically affects individuals under 20 years of age from tropical countries. Infrequently, pyomyositis occurs in individuals from temperate regions, usually in immunocompromised […]
Cardiac resynchronisation therapy in the presence of left-to-right intracardiac shunting: more good than harm?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
An elderly Chinese man with moderately impaired left ventricular function, left bundle branch block and ST-elevation myocardial infarction complicated by ventricular septal rupture had class IV heart failure symptoms refractory to medical and surgical interventions. As a treatment of last resort, a cardiac resynchronisation therapy (CRT) pacemaker was implanted apprehensively, as preoperative concerns were raised […]
Ebstein’s anomaly of tricuspid valve with rheumatic mitral stenosis: a rare association
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
Description A 16-year-old girl presented with progressive exertional dyspnoea and palpitations of 3-year duration. The medical history revealed one episode of fever with migratory polyarthritis at the age of 7 years, but it was not further evaluated. On presentation, she was in sinus rhythm with a pulse rate of 88/min and blood pressure of 110/80 […]
Painless acute myocardial infarction on Mount Kilimanjaro
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
An individual experiencing dyspnoea or syncope at high altitude is commonly diagnosed to have high-altitude pulmonary edema or cerebral edema. Acute myocardial infarction (AMI) is generally not considered in the differential diagnosis. There have been very rare cases of AMI reported only from Mount Everest. We report a case of painless ST segment elevation myocardial […]
Renal tubular acidosis type 4 in pregnancy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 51 δευτερόλεπτα
We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published. Renal tubular acidosis type 4 is a condition associated with increased urinary ammonia secondary to hypoaldosteronism or pseudohypoaldosteronism. Pregnancy may worsen the hyperkalaemia and acidosis of renal tubular acidosis type 4, possibly through an antialdosterone […]
Hand and Eye Dominance in Sport: Are Cricket Batters Taught to Bat Back-to-Front?
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 54 δευτερόλεπτα
Abstract Background When first learning to bimanually use a tool to hit a target (e.g., when chopping wood or hitting a golf ball), most people assume a stance that is dictated by their dominant hand. By convention, this means that a ‘right-handed’ or ‘left-handed’ stance that places the dominant hand closer to the striking end […]
Attitudes of Saudi parents with a deaf child towards prenatal diagnosis and termination of pregnancy.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Attitudes of Saudi parents with a deaf child towards prenatal diagnosis and termination of pregnancy.* Prenat Diagn. 2014 Feb;34(2):153-8 Authors: Alsulaiman A, Mousa A, Kondkar AA, Abu-Amero KK Abstract OBJECTIVE: The aim of this study was to assess the attitudes of Muslim parents from Saudi Arabia with a deaf child towards prenatal diagnosis (PND) and termination of pregnancy (TOP) for deafness and 29 other genetic and medical conditions. METHODS: A questionnaire mainly focused on parent's attitude toward PND and... περισσότερα »
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
*Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.* Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. DESIGN: Measures of spatial and non-spatial hearing abilities were obtained to compare performance obtained with different configurations of ac... περισσότερα »
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
*Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.* Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. DESIGN: Measures of spatial and non-spatial hearing abilities were obtained to compare performance obtained with different configurations of ac... περισσότερα »
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
*Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.* Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. DESIGN: Measures of spatial and non-spatial hearing abilities were obtained to compare performance obtained with different configurations of ac... περισσότερα »
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
*Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.* Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. DESIGN: Measures of spatial and non-spatial hearing abilities were obtained to compare performance obtained with different configurations of ac... περισσότερα »
Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival* Modern Pathology advance online publication, March 18 2016. doi:10.1038/modpathol.2016.45 Authors: Arjen HG Cleven, Ghadah A Al Sannaa, Inge Briaire-de Bruijn, Davis R Ingram, Matt van de Rijn, Brian P Rubin, Maurits W de Vries, Kelsey L Watson, Kelia E Torres, Wei-Lien Wang, Sjoerd G van Duinen, Pancras C W Hogendoorn, Alexander J Lazar & Judith V M G Bovée from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1MrvhSp via IFTTT
Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 56 δευτερόλεπτα
*Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin* Modern Pathology advance online publication, March 18 2016. doi:10.1038/modpathol.2016.60 Authors: Qinghua Xu, Jinying Chen, Shujuan Ni, Cong Tan, Midie Xu, Lei Dong, Lin Yuan, Qifeng Wang & Xiang Du from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1R34UrA via IFTTT
Association between ALDH1L1 gene polymorphism and neural tube defects in the Chinese Han population
Abstract We investigated single-nucleotide polymorphisms (SNPs) in the aldehyde dehydrogenase family1 L1 gene (*ALDH1L1*) and their association with neural tube defects (NTDs) in the Chinese population. A total of 271 NTDs cases and 192 healthy controls were used in this study. A total of 112 selected SNPs in the *ALDH1L1* gene were analyzed using the next-generation sequencing method. Statistical analysis was carried out to investigate the correlation between SNPs and patient susceptibility to NTDs. Statistical analysis revealed a significant correlation between the SNP sites rs4...περισσότερα »
The emerging roles of exosomes in tumor–stroma interaction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose The tumor–stroma interaction is critical for the development and progression of cancer. Cancer-associated fibroblasts (CAFs), one of the major components of the tumor stroma, can promote tumor growth and metastasis. Exosomes are secreted microvesicles that mediate cell-to-cell communication. Exosomal contents, including proteins, nucleic acids, and lipids, can be shuttled from donor cells to […]
A new recessive disease identified – PIGG gene causes intellectual disability, epilepsy and hypotonia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The objective of genetic medicine is to analyze all the genes that make up the human genome, in order to identify as many genetic diseases as possible. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R8fMko via IFTTT
Scientists pinpoint molecular signal that drives and enables spinal cord repair
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Researchers from King’s College London and the University of Oxford have identified a molecular signal, known as ‘neuregulin-1’, which drives and enables the spinal cord’s natural capacity for… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Um7qvb via IFTTT
New cytoplasmic role for proteins linked to neurological diseases, cancers
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Researchers at UT Southwestern Medical Center have identified a second role for a class of RNA-binding proteins, revealing new insights about neurological diseases and conditions associated with… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Me1Ubr via IFTTT
Traumatic basal ganglia hematoma following closed head injuries in children
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Purpose High-velocity trauma with acceleration/deceleration forces turns into shear stress over lenticulostriate or anterior choroidal arteries that lead to basal ganglia hemorrhage. Traumatic basal ganglia hematoma has rarely been described in pediatric population. The aim of this study was to present our clinical series of pediatric patients with traumatic basal ganglia hematoma and to […]
Simultaneous ventriculoperitoneal shunt removal and endoscopic third ventriculostomy for three patients previously treated for intracranial germ cell tumors more than 20 years ago
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Obstructive hydrocephalus is the most common complication of intracranial germ cell tumors (IGCTs). Although ventriculoperitoneal shunts (VPSs) were previously used for treating this condition, they have recently been replaced by endoscopic third ventriculostomy (ETV), as the latter can avoid various complications caused by a VPS and can preserve physiological cerebrospinal fluid (CSF) dynamics. […]
Erratum to: Health inequality in the Russian federation: an examination of the changes in concentration and achievement indices from 1994 to 2013
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WvK5oQ via IFTTT
Evaluation of the Effects of Teleconsultations on a Endocrinology Referral List
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Conditions: Diabetes Mellitus; Hypothyroidism; Hyperthyroidism; Goiter; Thyroid Nodule; Obesity Interventions: Other: Teleconsultation; Other: Protocol Sponsors: Hospital de Clinicas de Porto Alegre; Secretaria Estadual da Saúde do Estado do Rio Grande do Sul; Programa de Pesquisa e Pós-Graduação em Epidemiologia da UFRGS Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R33ixM via IFTTT
Early Integration of Palliative Care in Esophageal Cancer Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Condition: Esophageal Cancer Intervention: Other: Early Palliative Care Sponsors: McMaster University; St. Joseph’s Healthcare Hamilton Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WvK3xf via IFTTT
Evaluation for the Individualization of Therapy in Adenocarcinomas of the Gastroesophageal Junction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Condition: Adenocarcinoma of the Esophagogastric Junction Interventions: Drug: Oxaliplatin; Drug: Epirubicin; Drug: Capecitabine; Drug: 5-FU; Drug: Carboplatin; Drug: Paclitaxel; Radiation: radiation; Procedure: Biopsy Sponsor: Technische Universität München Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R33fCk via IFTTT
Cryopreservation method affects DNA fragmentation in trophectoderm and the speed of re-expansion in bovine blastocysts
Publication date: Available online 17 March 2016 Source:Cryobiology Author(s): Yasushi Inaba, Satoshi Miyashita, Tamás Somfai, Masaya Geshi, Satoko Matoba, Osamu Dochi, Takashi Nagai This study investigated re-expansion dynamics during culture of bovine blastocysts cryopreserved either by slow-freezing or vitrification. Also, the extent and localization of membrane damage and DNA fragmentation in re-expanded embryos were studied.… Continue reading Cryopreservation method affects DNA fragmentation in trophectoderm and the speed of re-expansion in bovine blastocysts
TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells
Abstract The intracellular cysteine protease caspase-1 is critically involved in obesity-induced inflammation in adipose tissue. A substantial body of evidence from immune cells, such as macrophages, has shown that caspase-1 activation depends largely on a protein complex, called the NLRP3 inflammasome, which consists of the NOD-like receptor (NLR) family protein NLRP3, the adaptor protein ASC,… Continue reading TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells
Evaluation for the Individualization of Therapy in Adenocarcinomas of the Gastroesophageal Junction
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Condition: Adenocarcinoma of the Esophagogastric Junction Interventions: Drug: Oxaliplatin; Drug: Epirubicin; Drug: Capecitabine; Drug: 5-FU; Drug: Carboplatin; Drug: Paclitaxel; Radiation: radiation; Procedure: Biopsy Sponsor: Technische Universität München Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R33fCk via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Plate Fixation of Distal Femur Fractures: A Protocol for a Study of Two Plate Options
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Condition: Femoral Fractures Interventions: Device: 95-degree Angled Blade Plate; Device: 4.5mm Condylar Locking Plate Sponsor: MetroHealth Medical Center Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1WvK2JM via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Molecular and Genomic Profiling of Head and Neck Tumors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Condition: Head and Neck Neoplasms Intervention: Sponsors: Montefiore Medical Center; National Institutes of Health (NIH) Recruiting – verified March 2016 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R33flB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The plant secretory pathway seen through the lens of the cell wall
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Secretion in plant cells is often studied by looking at well-characterised, evolutionarily conserved membrane proteins associated with particular endomembrane compartments. Studies using live cell microscopy and fluorescent proteins have illuminated the highly dynamic nature of trafficking, and electron microscopy studies have resolved the ultrastructure of many compartments. Biochemical and molecular analyses have further informed […]
Pharmacokinetic modeling of 18 Ffluorodeoxyglucose (FDG) for premature infants, and newborns through 5-year-olds
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Absorbed dose estimates for pediatric patients require pharmacokinetics that are, to the extent possible, age-specific. Such age-specific pharmacokinetic data are lacking for many of the diagnostic agents typically used in pediatric imaging. We have developed a pharmacokinetic model of [18F]fluorodeoxyglucose (FDG) applicable to premature infants and to 0- (newborns) to 5-year-old patients, which […]
Sepsis bei einem immunkompetenten Patienten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Raoultella ornithinolytica Infektionen des Menschen durch Raoultella ornithinolytica sind extrem selten und betrafen bisher nur Patienten mit einer zugrunde liegenden immunsystemschwächenden Erkrankung. Die aktuelle Kasuistik beschreibt erstmals eine Sepsis mit Nachweis einer Blutstrominfektion durch Raoultella ornithinolytica bei einem immunkompetenten männlichen Patienten und dessen erfolgreiche antibiotische Therapie. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1R8iuWY via IFTTT
Cells, Vol. 5, Pages 13: Src1 is a Protein of the Inner Nuclear Membrane Interacting with the Dictyostelium Lamin NE81
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The nuclear envelope (NE) consists of the outer and inner nuclear membrane (INM), whereby the latter is bound to the nuclear lamina. Src1 is a Dictyostelium homologue of the helix-extension-helix family of proteins, which also includes the human lamin-binding protein MAN1. Both endogenous Src1 and GFP-Src1 are localized to the NE during the entire cell […]
GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background GLI pathogenesis-related 1 (GLIPR1) was originally identified in glioblastomas and its expression was also found to be down-regulated in prostate cancer. Functional studies revealed both growth suppression and proapoptotic activities for GLIPR1 in multiple cancer cell lines. GLIPR1’s role in lung cancer has not been investigated. Protein arginine methyltransferase 5 (PRMT5) is a […]
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extreme and harsh to patients and often have limited success; the danger of cancer is intensified as it metastasizes to secondary locations such as […]
Cryopreservation method affects DNA fragmentation in trophectoderm and the speed of re-expansion in bovine blastocysts
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 March 2016 Source:Cryobiology Author(s): Yasushi Inaba, Satoshi Miyashita, Tamás Somfai, Masaya Geshi, Satoko Matoba, Osamu Dochi, Takashi Nagai This study investigated re-expansion dynamics during culture of bovine blastocysts cryopreserved either by slow-freezing or vitrification. Also, the extent and localization of membrane damage and DNA fragmentation in re-expanded embryos were studied. […]
Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols.
Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols.: Support Care Cancer. 2016 Mar 17; Authors: Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR, Barasch A, Migliorati CA, Milstein DM, Genot MT, Lansaat L, van der Brink R, Arnabat-Dominguez J, van der Molen L, Jacobi I, van Diessen J, de Lange J, Smeele LE, Schubert MM, Bensadoun RJ Abstract PURPOSE: There is a large body of evidence supporting the efficacy of low-level laser thera...περισσότερα »
Screening probiotic strains for safety: Evaluation of virulence and antimicrobial susceptibility of enterococci from healthy Chinese infants
Publication date: Available online 16 March 2016 *Source:*Journal of Dairy Science Author(s): Fen Zhang, Meiling Jiang, Cuixiang Wan, Xiaoyan Chen, Xiaoyong Chen, Xueying Tao, Nagendra P. Shah, Hua Wei The aim of this study was to evaluate the safety of enterococci isolated from Chinese infants and screen out potential probiotic candidates. One hundred eight strains were isolated from feces of 34 healthy infants, and 38 strains of Enterococcus spp. were categorized as follows: E. faecalis (22), E. faecium (10), E. hirae (3), E. durans (2), and E. casseliflavus (1). Of these, 72.7% o...περισσότερα »
Protection of cattle against rinderpest by vaccination with wild type but not attenuated strains of peste des petits ruminants virus.
*Protection of cattle against rinderpest by vaccination with wild type but not attenuated strains of peste des petits ruminants virus.* J Virol. 2016 Mar 16; Authors: Holzer B, Hodgson S, Logan N, Willett B, Baron MD Abstract Although Rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to restrict the extent to which live virus is distributed in facilities around the world, and to prepare for any reappearance of the disease, whether through deliberate or accidental release. In an effort to find an alternative vaccine which could be used in place o... περισσότερα »
Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols.
*Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols.* Support Care Cancer. 2016 Mar 17; Authors: Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Elad S, Hamblin MR, Barasch A, Migliorati CA, Milstein DM, Genot MT, Lansaat L, van der Brink R, Arnabat-Dominguez J, van der Molen L, Jacobi I, van Diessen J, de Lange J, Smeele LE, Schubert MM, Bensadoun RJ Abstract PURPOSE: There is a large body of evidence supporting the efficacy of low-level laser the...περισσότερα »
Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.
*Edentulism and transplant-associated complications in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation.* Support Care Cancer. 2016 Mar 17; Authors: Toro JJ, Gushiken FC, Schneider D, Lee S, Haile DJ, Freytes CO Abstract PURPOSE: Patients undergoing autologous hematopoietic stem cell transplantation (HSCT) are at risk for oral complications which may cause significant morbidity. The aim of this study was to compare the incidence of toxicities and complications in edentulous and dentate patients undergoing autologous HSCT for multiple my...περισσότερα »
Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.
*Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations.* Support Care Cancer. 2016 Mar 16; Authors: Zecha JA, Raber-Durlacher JE, Nair RG, Epstein JB, Sonis ST, Elad S, Hamblin MR, Barasch A, Migliorati CA, Milstein DM, Genot MT, Lansaat L, van der Brink R, Arnabat-Dominguez J, van der Molen L, Jacobi I, van Diessen J, de Lange J, Smeele LE, Schubert MM, Bensadoun RJ Abstract PURPOSE: There is a large body of evidence supporting the efficacy...περισσότερα »
A critical review of 20 years of parotid gland surgery.
*A critical review of 20 years of parotid gland surgery.* Acta Otolaryngol. 2016 Mar 17;:1-6 Authors: Knopf A, Szyper M, Mansour N, Sonnenberg J, Hofauer B, Niedermeyer H Abstract Conclusion PG surgery provides sufficient radicality with a minimum of functional loss. Patient's outcome is associated with the reliable estimation of the lesional entity/dignity. Diagnostic approaches are required to determine morphological aspects, avoid unnecessary surgery, and to reliable identify primary carcinomas/occult metastases. Objectives The pre-operative assessment of parotid gland (PG) le... περισσότερα »
The effect of inlay butterfly cartilage tympanoplasty technique on compliance.
*The effect of inlay butterfly cartilage tympanoplasty technique on compliance.* Acta Otolaryngol. 2016 Mar 17;:1-4 Authors: Ersoy Callioglu E, Tuzuner A, Demirci S, Bercin AS, Oguzhan T, Korkmaz MH Abstract CONCLUSION: IBCT technique should be preferred owing to its high graft survival rate and ABG gain. While no significant difference was found in middle ear pressures between ears that underwent IBCT and normal ears, compliance values were found to be decreased in patients undergoing IBCT. However, the lack of correlation between ABG gain and compliance values indicated that c... περισσότερα »
Frequency-dependent loudness balancing in bimodal cochlear implant users.
*Frequency-dependent loudness balancing in bimodal cochlear implant users.* Acta Otolaryngol. 2016 Mar 17;:1-7 Authors: Veugen LC, Chalupper J, Snik AF, van Opstal AJ, Mens LH Abstract Conclusion In users of a cochlear implant (CI) and a hearing aid (HA) in contralateral ears, frequency-dependent loudness balancing between devices did, on average, not lead to improved speech understanding as compared to broadband balancing. However, nine out of 15 bimodal subjects showed significantly better speech understanding with either one of the fittings. Objectives Sub-optimal fittings and ... περισσότερα »
"Genet Mol Res"[jour]; +50 new citations
50 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"Genet Mol Res"[jour]* These pubmed results were generated on 2016/03/18 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/1nTMQEg via IFTTT
Methylene blue prevents retinal damage in an experimental model of ischemic proliferative retinopathy.
*Methylene blue prevents retinal damage in an experimental model of ischemic proliferative retinopathy.* Am J Physiol Regul Integr Comp Physiol. 2016 Mar 16;:ajpregu.00266.2015 Authors: Rey-Funes M, Larrayoz IM, Fernández JC, Contartese DS, Rolón F, Inserra PI, Martínez-Murillo R, López-Costa JJ, Dorfman VB, Martínez A, Loidl CF Abstract Perinatal asphyxia induces retinal lesions, generating ischemic proliferative retinopathy which may result in blindness. Previously, we showed that the nitrergic system was involved in the physiopathology of perinatal asphyxia. Here we analyze th... περισσότερα »
Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression.
*Silibinin inhibits triple negative breast cancer cell motility by suppressing TGF-β2 expression.* Tumour Biol. 2016 Mar 16; Authors: Kim S, Han J, Jeon M, You D, Lee J, Kim HJ, Bae S, Nam SJ, Lee JE Abstract Transforming growth factor-beta (TGF-β) is a multifunctional cytokine that regulates many biological events including cell motility and angiogenesis. Here, we investigated the role of elevated TGF-β2 level in triple negative breast cancer (TNBC) cells and the inhibitory effect of silibinin on TGF-β2 action in TNBC cells. Breast cancer patients with high TGF-β2 expression hav... περισσότερα »
Scheduled versus Pro Re Nata Dosing in the VIEW Trials.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Scheduled versus Pro Re Nata Dosing in the VIEW Trials.* Ophthalmology. 2015 Dec;122(12):2497-503 Authors: Richard G, Monés J, Wolf S, Korobelnik JF, Guymer R, Goldstein M, Norenberg C, Sandbrink R, Zeitz O Abstract PURPOSE: To analyze visual acuity (VA) outcomes before and after preplanned treatment regimen change in the VIEW studies at week 52 (W52). DESIGN: Multiple post hoc analyses for retrospectively defined subgroups in 2 multicenter, multinational, double-masked trials. PARTICIPANTS: Two thousand four hundr... περισσότερα »
Outcomes with As-Needed Ranibizumab after Initial Monthly Therapy: Long-Term Outcomes of the Phase III RIDE and RISE Trials.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Outcomes with As-Needed Ranibizumab after Initial Monthly Therapy: Long-Term Outcomes of the Phase III RIDE and RISE Trials.* Ophthalmology. 2015 Dec;122(12):2504-13.e1 Authors: Boyer DS, Nguyen QD, Brown DM, Basu K, Ehrlich JS, RIDE and RISE Research Group Abstract PURPOSE: To determine whether the efficacy and safety achieved with monthly ranibizumab as treatment for diabetic macular edema (DME) can be maintained with less-than-monthly treatment. DESIGN: Open-la... περισσότερα »
Prospective Trial of Treat-and-Extend versus Monthly Dosing for Neovascular Age-Related Macular Degeneration: TREX-AMD 1-Year Results.
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Prospective Trial of Treat-and-Extend versus Monthly Dosing for Neovascular Age-Related Macular Degeneration: TREX-AMD 1-Year Results.* Ophthalmology. 2015 Dec;122(12):2514-22 Authors: Wykoff CC, Croft DE, Brown DM, Wang R, Payne JF, Clark L, Abdelfattah NS, Sadda SR, TREX-AMD Study Group Abstract PURPOSE: To assess prospectively a treat-and-extend (TREX) management strategy compared with monthly dosing of intravitreal ranibizumab in treatment-naïve neovascular ag...περισσότερα »
Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Association of Baseline Characteristics and Early Vision Response with 2-Year Vision Outcomes in the Comparison of AMD Treatments Trials (CATT).* Ophthalmology. 2015 Dec;122(12):2523-31.e1 Authors: Ying GS, Maguire MG, Daniel E, Ferris FL, Jaffe GJ, Grunwald JE, Toth CA, Huang J, Martin DF, Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group Abstract PURPOSE: To evaluate the association of baseline characteristics and early visual acuity (VA) response with visual outcomes at year... περισσότερα »
Tap water versus sterile normal saline in wound swabbing: a double-blind randomized controlled trial
Journal of Wound, Ostomy, and Continence Nursing from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ30I via IFTTT
Time to follow commands and duration of posttraumatic amnesia predict GOS-E Peds scores 1 to 2 years after TBI in children requiring inpatient rehabilitation
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTqxi via IFTTT
Incidence, characterization, and predictors of sleep apnea in consecutive brain injury rehabilitation admissions
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ30B via IFTTT
Importance of psychological factors for the recovery from a first episode of acute non-specific neck pain - a longitudinal observational study
Chiropractic & Manual Therapies from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTnBF via IFTTT
Anxiety prevalence following spinal cord injury: a meta-analysis
Spinal Cord from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ1G0 via IFTTT
The effects of kangaroo care in the neonatal intensive care unit on the physiological functions of preterm infants, maternal–infant attachment, and maternal stress
Journal of Pediatric Nursing from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTnBB via IFTTT
Normalization of coagulopathy is associated with improved outcome after isolated traumatic brain injury
Journal of Clinical Neuroscience from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ2Kd via IFTTT
Sleep features on continuous electroencephalography predict rehabilitation outcomes after severe traumatic brain injury`
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTnBz via IFTTT
Long-term treatment with methylphenidate for fatigue after traumatic brain injury
Acta Neurologica Scandinavica from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ2K4 via IFTTT
Soluble urokinase plasminogen activator receptor: a new biomarker in the pediatric intensive care unit
The Indian Journal of Pediatrics from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTqgU via IFTTT
Cost-effectiveness of individualized nutrition and exercise therapy for rehabilitation following hip fracture
Journal of Rehabilitation Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ1pr via IFTTT
Actigraphic and sleep diary measures in veterans with traumatic brain injury: discrepancy in selected sleep parameters
Journal of Head Trauma Rehabilitation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTqgP via IFTTT
Clinical outcomes of and management strategy for perforations associated with endoscopic submucosal dissection of an upper gastrointestinal epithelial neoplasm
Surgical Endoscopy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ195 via IFTTT
The effect from maximal bench press strength training on work economy during wheelchair propulsion in men with spinal cord injury
Spinal Cord from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTnl7 via IFTTT
Sleep disorders associated with traumatic brain injury – a review
Pediatric Neurology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ18X via IFTTT
Single-port laparoscopic surgery in acute appendicitis: retrospective comparative analysis for 618 patients
Surgical Endoscopy from Emergency Medicine via ola Kala on Inoreader http://ift.tt/21yTnl3 via IFTTT
Does rapid diffusion of HbA1c testing affect amputation rates?
Vascular and Endovascular Surgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UlJ0Sv via IFTTT
The Instrument of Voice: The “True” Vocal Cord or Vocal Fold?
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Andy Hall, Richard Cobb, Karan Kapoor, Romana Kuchai, Guri Sandhu from Swallowing and Swallowing Disorders (Dysphagia) via a.lsfakia on Inoreader http://ift.tt/1nU6pwo via IFTTT
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Arya W. Namin, Kara M. Christopher, John F. Eisenbeis ObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in ... περισσότερα »
Preoperative Imaging for Thyroid Cancer: Beyond Ultrasonography.
*Preoperative Imaging for Thyroid Cancer: Beyond Ultrasonography.* JAMA Otolaryngol Head Neck Surg. 2016 Mar 17; Authors: Orloff LA, Randolph GW PMID: 26985777 [PubMed - as supplied by publisher] from thyroid via a.lsfakia on Inoreader http://ift.tt/1R7WkEq via IFTTT
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter.
*Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter.* Ulus Cerrahi Derg. 2016;32(1):67-70 Authors: Kesici U, Koral Ö, Karyağar S, Kesici S, Yılbaş A, Karyağar S, Mataracı E, Mataracı İ Abstract Ectopic thyroid tissue has been found from the tongue to the diaphragm. The most common ectopic thyroid tissue has been found in the tongue, submandibular region, cervical lymph nodes, larynx, trachea, oesophagus, mediastinum, diaphragm and heart respectively. "Forgotten goiter" is an extremely rare disease which is defined as a mediastinal thyroid mas... περισσότερα »
[Background data of spontaneous tumors in F344/DuCrlCrlj rats].
[image: http:--linkout.jstage.jst.go.jp-logo.gif] Related Articles *[Background data of spontaneous tumors in F344/DuCrlCrlj rats].* Sangyo Eiseigaku Zasshi. 2015;57(3):85-96 Authors: Takanobu K, Aiso S, Umeda Y, Senoh H, Saito M, Katagiri T, Ikawa N, Ishikawa H, Mine T, Take M, Haresaku M, Matsumoto M, Fukushima S Abstract INTRODUCTION: We investigated the 2-year survival rate and incidence of spontaneous tumors in F344/DuCrlCrlj rats used in carcinogenicity studies of chemical substances. Records for animals used in the control groups of carcinogenicity studies which were conduc... περισσότερα »
Spontaneous Closure of a Full-Thickness Macular Hole Associated with Proliferative Diabetic Retinopathy and Persistent Vitreomacular Traction
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Diabetic retinopathy worsens the prognosis of macular holes compared to those of idiopathic etiology. While spontaneous closure of idiopathic macular holes is a well-documented phenomenon, spontaneous closure of macular holes associated with proliferative diabetic retinopathy is rare. We report a case of spontaneous closure of a macular hole associated with proliferative diabetic retinopathy and persistent […]
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant. Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with […]
Metformin Inhibits Prostate Cancer Cell Proliferation, Migration, and Tumor Growth through Upregulation of PEDF Expression.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Metformin Inhibits Prostate Cancer Cell Proliferation, Migration, and Tumor Growth through Upregulation of PEDF Expression. Cancer Biol Ther. 2016 Mar 17;:0 Authors: Chen X, Li C, He T, Mao J, Li C, Lyu J, Meng QH Abstract Metformin has been reported to inhibit the growth of various types of cancers, including prostate cancer. Yet the […]
Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: biomarker for treatment selection exclusion or inclusion?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: biomarker for treatment selection exclusion or inclusion? Cancer Biol Ther. 2016 Mar 17;:0 Authors: Leibrand CR, Price DK, Figg WD Abstract Currently there are no molecular biomarkers used to help guide treatment selection for those patients with castration-resistant prostate cancer. A recent […]
Metformin Inhibits Prostate Cancer Cell Proliferation, Migration, and Tumor Growth through Upregulation of PEDF Expression.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Metformin Inhibits Prostate Cancer Cell Proliferation, Migration, and Tumor Growth through Upregulation of PEDF Expression. Cancer Biol Ther. 2016 Mar 17;:0 Authors: Chen X, Li C, He T, Mao J, Li C, Lyu J, Meng QH Abstract Metformin has been reported to inhibit the growth of various types of cancers, including prostate cancer. Yet the […]
Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: biomarker for treatment selection exclusion or inclusion?
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: biomarker for treatment selection exclusion or inclusion? Cancer Biol Ther. 2016 Mar 17;:0 Authors: Leibrand CR, Price DK, Figg WD Abstract Currently there are no molecular biomarkers used to help guide treatment selection for those patients with castration-resistant prostate cancer. A recent […]
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant. Int J Audiol. 2016 Mar 17;:1-8 Authors: Plant K, Babic L Abstract OBJECTIVE: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with […]
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alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Folia Phoniatr Logop 2015;67:219-220 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1MrcKpw via IFTTT
Benign Paroxysmal Positional Vertigo in 2 Children: A Case Series.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Benign Paroxysmal Positional Vertigo in 2 Children: A Case Series. Pediatr Phys Ther. 2016 Mar 16; Authors: Fay JL Abstract PURPOSE: The purpose of this case report is to present the cases of 2 boys with benign paroxysmal positional vertigo (BPPV). KEY POINTS: Patient A (11 years old) and Patient B (9 years old) had […]
Acute vestibular syndrome: a critical review and diagnostic algorithm concerning the clinical differentiation of peripheral versus central aetiologies in the emergency department.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Acute vestibular syndrome: a critical review and diagnostic algorithm concerning the clinical differentiation of peripheral versus central aetiologies in the emergency department. J Neurol. 2016 Mar 16; Authors: Venhovens J, Meulstee J, Verhagen WI Abstract Almost 20 % of cerebral ischaemic strokes occur in the posterior circulation. Estimates are that 20 % of these patients […]
The Instrument of Voice: The “True” Vocal Cord or Vocal Fold?
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Andy Hall, Richard Cobb, Karan Kapoor, Romana Kuchai, Guri Sandhu from #ENT via xlomafota13 on Inoreader http://ift.tt/1nU6pwo via IFTTT
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Arya W. Namin, Kara M. Christopher, John F. Eisenbeis ObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in ... περισσότερα »
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
Abstract Objectives Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas (OPSCCs) have an improved prognosis compared to HPV-negative OPSCCs. Several theories have been proposed to explain this relatively good prognosis. One hypothesis is a difference in immune response. In this study, we compared tumor-infiltrating CD3+, CD4+, CD8+ T-cells, and granzyme inhibitors (SERPINB1, SERPINB4, and SERPINB9) between HPV-positive and HPV-negative tumors and the relation with survival. Methods Protein expression of tumor-infiltrating lymphocytes (TILs) (CD... περισσότερα »
Detecting Aspiration and Penetration Using FEES With and Without Food Dye
Abstract The objective of this investigation was to determine if there were differences in identifying airway invasion (penetration or aspiration) during fiberoptic endoscopic evaluations of swallowing (FEES) for green-dyed versus non-dyed liquids. Forty adult inpatients in an acute care hospital underwent FEES, with both green-dyed liquids and naturally white liquids. Three speech-language pathologists rated aspiration and penetration for trials of nectar-thick milk and thin milk, both with and without green food dye. A subset of participants having excess pharyngeal/laryngeal se... περισσότερα »
The Instrument of Voice: The “True” Vocal Cord or Vocal Fold?
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Andy Hall, Richard Cobb, Karan Kapoor, Romana Kuchai, Guri Sandhu from #ENT via xlomafota13 on Inoreader http://ift.tt/1nU6pwo via IFTTT
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Arya W. Namin, Kara M. Christopher, John F. Eisenbeis ObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in ... περισσότερα »
The definition, diagnostic testing and management of chronic inducible urticarias – update and revision of the EAACI/GA2LEN/EDF/UNEV 2009 consensus panel recommendations
[image: cover.gif?v=1&s=ff195289b99d5ad4af62a487] Abstract These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (1), a joint initiative of the EAACI (European Academy of Allergology and Clinical Immunology) Dermatology Section, the GA2LEN (Global Allergy and Asthma European Network) task force on urticaria, the EDF (European Dermatology Forum) and UNEV (urticaria network e.V.). Changes to the 2009 consensus report reflect th...περισσότερα »
IJMS, Vol. 17, Pages 401: Biosurfactants: Multifunctional Biomolecules of the 21st Century
[image: ag] In the era of global industrialisation, the exploration of natural resources has served as a source of experimentation for science and advanced technologies, giving rise to the manufacturing of products with high aggregate value in the world market, such as biosurfactants. Biosurfactants are amphiphilic microbial molecules with hydrophilic and hydrophobic moieties that partition at liquid/liquid, liquid/gas or liquid/solid interfaces. Such characteristics allow these biomolecules to play a key role in emulsification, foam formation, detergency and dispersal, which are ... περισσότερα »
IJMS, Vol. 17, Pages 399: Chemical Elicitor-Induced Modulation of Antioxidant Metabolism and Enhancement of Secondary Metabolite Accumulation in Cell Suspension Cultures of Scrophularia kakudensis Franch
[image: ag] Scrophularia kakudensis is an important medicinal plant with pharmaceutically valuable secondary metabolites. To develop a sustainable source of naturaceuticals with vital therapeutic importance, a cell suspension culture was established in S. kakudensis for the first time. Friable calli were induced from the leaf explants cultured on a Murashige and Skoog (MS) medium containing 3.0 mg·L−1 6-benzyladenine (BA) in a combination with 2 mg·L−1 2,4-dichlorophenoxy acetic acid (2,4-D). From the callus cultures, a cell suspension culture was initiated and the cellular differ... περισσότερα »
IJMS, Vol. 17, Pages 387: TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation
[image: ag] Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) is reported to be a crucial gene that regulates autophagy flux and lysosome function. Therefore, we investigated the role of TFE3 in a cell model of hepatic steatosis. We constructed L02 hepatocyte lines that stably over-expressed or knocked down the expression of TFE3. Subsequently, the effects of TFE3 on hepatocellular lipid metabolism were determined by autophagy flux assay, lipid oil red O (ORO) staining, immunofluorescence staining, and mitochondrial...περισσότερα »
IJMS, Vol. 17, Pages 274: Identification and Characterization of the Gene CYP340W1 from Plutella xylostella and Its Possible Involvement in Resistance to Abamectin
Abamectin has been used to control the diamondback moth, Plutella xylostella (P. xylostella), which is a major agricultural pest that can rapidly develop resistance against insecticides including abamectin. Although cytochrome P450 has been confirmed to play an important role in resistance in P. xylostella, the specific P450 genes associated with the resistance are unclear. The full-length cDNA of the cytochrome P450 gene CYP340W1 was cloned and characterized in the present study. The cDNA assembly yielded a sequence of 1929 bp, containing the open reading frame (ORF) 1491 bp and ...περισσότερα »
IJMS, Vol. 17, Pages 400: Retrospective Study of Metastatic Melanoma and Renal Cell Carcinoma to the Brain with Multivariate Analysis of Prognostic Pre-Treatment Clinical Factors
Patients with brain metastasis from renal cell carcinoma (RCC) or melanoma have historically had very poor prognoses of less than one year. Stereotactic radiosurgery (SRS) can be an effective treatment for patients with these tumors. This study analyzes the effect of pretreatment prognostic factors on overall survival (OS) for RCC and melanoma patients with metastasis to the brain treated with SRS. A total of 122 patients with brain metastases from either RCC or melanoma were grouped by age at brain metastasis diagnosis, whether they received whole brain radiation therapy (WBRT) i... περισσότερα »
IJMS, Vol. 17, Pages 407: The Role of KV7.3 in Regulating Osteoblast Maturation and Mineralization
KCNQ (KV7) channels are voltage-gated potassium (KV) channels, and the function of KV7 channels in muscles, neurons, and sensory cells is well established. We confirmed that overall blockade of KV channels with tetraethylammonium augmented the mineralization of bone-marrow-derived human mesenchymal stem cells during osteogenic differentiation, and we determined that KV7.3 was expressed in MG-63 and Saos-2 cells at the mRNA and protein levels. In addition, functional KV7 currents were detected in MG-63 cells. Inhibition of KV7.3 by linopirdine or XE991 increased the matrix minerali...περισσότερα »
Hybrid 3D Structures of ZnO Nanoflowers and PdO Nanoparticles as a Highly Selective Methanol Sensor
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00326E, Paper Debanjan Acharyya, K Y Huang, P P Chattopadhyay, Mon Shu Ho, hans J Fecht, Partha Bhattacharyya The present study concerns enhancement of methanol selectivity of three dimensional (3D) nanoflowers (NFs) of ZnO by dispersing Nickel oxide (NiO) and Palladium oxide (PdO) nanoparticles on the surface of... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1WvvhGD Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,C... περισσότερα »
Development of a biosensing system for tacrine based on nitrogen-doped graphene quantum dots and acetylcholinesterase
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN00357E, Paper Sandra Benitez-Martinez, Encarnacion Caballero-Diaz, M Valcarcel This work presents a novel fluorescent sensor for determination of tacrine by combining the magnificent fluorescence properties of nitrogen-doped graphene quantum dots (N-GQDs) with the high potential of acetylcholinesterase (AChE)... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1Wvvh9C Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete... περισσότερα »
IJMS, Vol. 17, Pages 407: The Role of KV7.3 in Regulating Osteoblast Maturation and Mineralization
KCNQ (KV7) channels are voltage-gated potassium (KV) channels, and the function of KV7 channels in muscles, neurons, and sensory cells is well established. We confirmed that overall blockade of KV channels with tetraethylammonium augmented the mineralization of bone-marrow-derived human mesenchymal stem cells during osteogenic differentiation, and we determined that KV7.3 was expressed in MG-63 and Saos-2 cells at the mRNA and protein levels. In addition, functional KV7 currents were detected in MG-63 cells. Inhibition of KV7.3 by linopirdine or XE991 increased the matrix minerali...περισσότερα »
Materials, Vol. 9, Pages 208: Site-Control of InAs/GaAs Quantum Dots with Indium-Assisted Deoxidation
Site-controlled epitaxial growth of InAs quantum dots on GaAs substrates patterned with periodic nanohole arrays relies on the deterministic nucleation of dots into the holes. In the ideal situation, each hole should be occupied exactly by one single dot, with no nucleation onto planar areas. However, the single-dot occupancy per hole is often made difficult by the fact that lithographically-defined holes are generally much larger than the dots, thus providing several nucleation sites per hole. In addition, deposition of a thin GaAs buffer before the dots tends to further widen th... περισσότερα »
Molecules, Vol. 21, Pages 375: A Novel Biomolecule-Mediated Reduction of Graphene Oxide: A Multifunctional Anti-Cancer Agent
Graphene oxide (GO) is a monolayer of carbon atoms that form a dense honeycomb structure, consisting of hydroxyl and epoxide functional groups on the two accessible sides and carboxylic groups at the edges. In contrast, graphene is a two-dimensional sheet of sp2-hybridized carbon atoms packed into a honeycomb lattice. Graphene has great potential for use in biomedical applications due to its excellent physical and chemical properties. In this study, we report a facile and environmentally friendly approach for the synthesis of reduced graphene oxide (rGO) using uric acid (UA). The ...περισσότερα »
Molecules, Vol. 21, Pages 373: Coenzyme Q and Its Role in the Dietary Therapy against Aging
Coenzyme Q (CoQ) is a naturally occurring molecule located in the hydrophobic domain of the phospholipid bilayer of all biological membranes. Shortly after being discovered, it was recognized as an essential electron transport chain component in mitochondria where it is particularly abundant. Since then, more additional roles in cell physiology have been reported, including antioxidant, signaling, death prevention, and others. It is known that all cells are able to synthesize functionally sufficient amounts of CoQ under normal physiological conditions. However, CoQ is a molecule f... περισσότερα »
The Instrument of Voice: The “True” Vocal Cord or Vocal Fold?
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Andy Hall, Richard Cobb, Karan Kapoor, Romana Kuchai, Guri Sandhu from Speech via a.lsfakia on Inoreader http://ift.tt/1nU6pwo via IFTTT
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
Publication date: Available online 18 March 2016 *Source:*Journal of Voice Author(s): Arya W. Namin, Kara M. Christopher, John F. Eisenbeis ObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in ... περισσότερα »
Detecting Aspiration and Penetration Using FEES With and Without Food Dye
Abstract The objective of this investigation was to determine if there were differences in identifying airway invasion (penetration or aspiration) during fiberoptic endoscopic evaluations of swallowing (FEES) for green-dyed versus non-dyed liquids. Forty adult inpatients in an acute care hospital underwent FEES, with both green-dyed liquids and naturally white liquids. Three speech-language pathologists rated aspiration and penetration for trials of nectar-thick milk and thin milk, both with and without green food dye. A subset of participants having excess pharyngeal/laryngeal se... περισσότερα »
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from Neurology via xlomafota13 on Inoreader http://ift.tt/1R7MBhs via IFTTT
Generation of Directly Converted Human Osteoblasts that Are Free of Exogenous Gene and Xenogenic Protein
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Generation of osteoblasts from human somatic cells may be applicable in an effective transplantation therapy against bone diseases. Recently we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some transcription factor genes via retroviral vectors. However, retroviral vector-mediated transduction may potentially cause tumor formation from the infected cells, thus a […]
Real-Time In Vivo Confocal Fluorescence Imaging of Prostate Cancer Bone-Marrow Micrometastasis Development at the Cellular Level in Nude Mice
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT In the present report, we demonstrate in vivo fluorescence imaging of bone-marrow micrometastasis of prostate cancer at the cellular level in nude mice. PC-3 human prostate cancer cells labeled with green fluorescent protein (GFP) or red fluorescent protein (RFP) were injected into the left ventricle or intratibial bone marrow of nude mice. PC-3-GFP, as […]
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas (OPSCCs) have an improved prognosis compared to HPV-negative OPSCCs. Several theories have been proposed to explain this relatively good prognosis. One hypothesis is a difference in immune response. In this study, we compared tumor-infiltrating CD3+, CD4+, CD8+ T-cells, and granzyme inhibitors (SERPINB1, SERPINB4, and […]
Radiothérapie postopératoire des cancers bronchiques non à petites cellules : efficacité, volume cible, dose
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 March 2016 Source:Cancer/Radiothérapie Author(s): G. Dupic, A. Bellière-Calandry from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VjfUmp via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Radiothérapie postopératoire des cancers bronchiques non à petites cellules : efficacité, volume cible, dose
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 March 2016 Source:Cancer/Radiothérapie Author(s): G. Dupic, A. Bellière-Calandry Les cancers bronchiques non à petites cellules de stade IIIA-N2 exposent à un risque de récidive locale de 20 à 40 %, même après chirurgie et chimiothérapie adjuvante. La radiothérapie postopératoire médiastinale a démontré son intérêt en termes de contrôle local, mais […]
Médulloblastomes de l’enfant : étude rétrospective portant sur 52 patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 17 March 2016 Source:Cancer/Radiothérapie Author(s): C. Vigneron, D. Antoni, A. Coca, N. Entz-Werlé, P. Lutz, A. Spiegel, S. Jannier, C. Niederst, D. Jarnet, P. Meyer, P. Kehrli, G. Noël Objectif de l’étudeAnalyse rétrospective des résultats obtenus chez 52 enfants irradiés pour un médulloblastome.Patients et méthodesEntre 1974 et 2012, 52 enfants âgés […]
The Instrument of Voice: The “True” Vocal Cord or Vocal Fold?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 March 2016 Source:Journal of Voice Author(s): Andy Hall, Richard Cobb, Karan Kapoor, Romana Kuchai, Guri Sandhu from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nU6pwo via IFTTT
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 March 2016 Source:Journal of Voice Author(s): Arya W. Namin, Kara M. Christopher, John F. Eisenbeis ObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct […]
A case of Paget-Schroetter syndrome (PSS) in a young judo tutor: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background We present a case of unsuspected Paget-Schroetter syndrome (also called effort thrombosis), one of the rare causes of upper extremity deep vein thrombosis. To the best of our knowledge, this was the first such case in our hospital. Our patient may have been discharged with an incomplete diagnosis and inappropriate management but for […]
Liposarcoma masquerading as an inflammatory pseudotumor: a case report
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Distinguishing an atypical lipomatous tumor/well-differentiated liposarcoma from a benign lipomatous tumor on morphology alone can be difficult and there is an established role for MDM2 fluorescent in situ hybridization studies in making this differential diagnosis. There is no literature on the role for MDM2 fluorescent in situ hybridization studies in distinguishing between a […]
Effects of disinfection of the umbilical cord of piglets on healing and albumin levels
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The objective was to assess the effects of using drying powder and iodine solution during navel cords disinfection handling on performance and blood variables (total protein, albumin, and globulin) in newborn piglets. Four treatments were used: (1) tie, cut, and iodine (TCI); (2) tie, cut, and spread drying powder (TCDP); (3) tie, cut, iodine, […]
Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objectives Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinomas (OPSCCs) have an improved prognosis compared to HPV-negative OPSCCs. Several theories have been proposed to explain this relatively good prognosis. One hypothesis is a difference in immune response. In this study, we compared tumor-infiltrating CD3+, CD4+, CD8+ T-cells, and granzyme inhibitors (SERPINB1, SERPINB4, and […]
Detecting Aspiration and Penetration Using FEES With and Without Food Dye
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract The objective of this investigation was to determine if there were differences in identifying airway invasion (penetration or aspiration) during fiberoptic endoscopic evaluations of swallowing (FEES) for green-dyed versus non-dyed liquids. Forty adult inpatients in an acute care hospital underwent FEES, with both green-dyed liquids and naturally white liquids. Three speech-language pathologists rated aspiration […]
Determining the responses of vegetation to natural processes and human impacts in north-eastern Poland during the last millennium: combined pollen, geochemical and historical data
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Pollen, charcoal and geochemical investigations were carried out on annually laminated sediments of Lake Żabińskie (54°07′54.5″N; 21°59′01.1″E) and the results were combined with historical and climate data to better understand the mechanism behind plant cover transformations. A millennium-long record of environmental history at 6-years time resolution permitted an assessment of vegetation responses to past […]
Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells Cancer Gene Therapy advance online publication, March 18 2016. doi:10.1038/cgt.2016.8 Authors: A Takasu, A Masui, M Hamada, T Imai, S Iwai & Y Yura from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1WvCre1 via IFTTT
Precise and efficient siRNA design: a key point in competent gene silencing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Precise and efficient siRNA design: a key point in competent gene silencing Cancer Gene Therapy advance online publication, March 18 2016. doi:10.1038/cgt.2016.4 Authors: E Fakhr, F Zare & L Teimoori-Toolabi from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VjdUue via IFTTT
Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells Cancer Gene Therapy advance online publication, March 18 2016. doi:10.1038/cgt.2016.3 Authors: X Sun, C Xu, S-C Tang, J Wang, H Wang, P Wang, N Du, S Qin, G Li, S Xu, Z Tao, Dapeng Liu & H Ren from #AlexandrosSfakianakis via […]
Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Adenovirus-directed expression of TIPE2 suppresses gastric cancer growth via induction of apoptosis and inhibition of AKT and ERK1/2 signaling Cancer Gene Therapy advance online publication, March 18 2016. doi:10.1038/cgt.2016.6 Authors: Y Zhu, M Tao, J Wu, Y Meng, C Xu, Y Tian, X Zhou, J Xiang, H Zhang & Y Xie from #AlexandrosSfakianakis via Alexandros […]
Cutaneous reactions to Pirfenidone: a new kid on the block
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract We would like to highlight the potentially severe cutaneous adverse effects of a relatively new drug, Pirfenidone (5-methyl-1-phenyl-[1H]-pyridine), which is becoming increasingly used for the treatment of idiopathic pulmonary fibrosis (IPF). This article is protected by copyright. All rights reserved. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/258BONl via IFTTT
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