The subepithelial autologous connective tissue graft (SCTG) vs. a porcine collagen matrix (CM)
Soft tissue volume alterations after connective tissue grafting at teeth. The subepithelial autologous connective tissue graft (SCTG) vs. a porcine collagen matrix (CM). A preclinical volumetric analysis: Abstract Aim This study evaluates a porcine collagen matrix (CM) for soft tissue thickening in comparison to the subepithelial connective tissue graft (SCTG). Material and Methods In eight beagle dogs, soft tissue thickening was performed at the buccal aspects of the upper canines (SCTG and CM). Impressions were taken before augmentation (i1), after surgery (i2), after one (i3), th... περισσότερα »
Progression from gingivitis to periodontitis
Longitudinal quantification of the GCF proteome during progression from gingivitis to periodontitis in a canine model: Abstract Aim Inflammatory periodontal disease is widespread in dogs. This study evaluated site-specific changes in the canine gingival crevicular fluid (GCF) proteome during longitudinal progression from very mild gingivitis to mild periodontitis. Periodontitis diagnosis in dogs requires general anaesthesia with associated risks and costs; our ultimate aim was to develop a periodontitis diagnostic for application in conscious dogs. The objective of this work was to... περισσότερα »
Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment
Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment: Abstract Objective Autophagy, which provides a mechanism for turnover cellular organelles and proteins through a lysosome-dependent degradation pathway, has been related to the pathogenesis of inflammatory disorders and other diseases. Therefore, the aim of this research is to study the role of autophagy in PDLSCs and provide a new strategy for treatment or prevention of periodontitis. Methods We used immunohistochemistry to detect the LC3 expression in PDL tis... περισσότερα »
Combined effects of low-level laser therapy and human bone marrow mesenchymal stem cell conditioned medium on viability of human dermal fibroblasts cultured in a high-glucose medium
Combined effects of low-level laser therapy and human bone marrow mesenchymal stem cell conditioned medium on viability of human dermal fibroblasts cultured in a high-glucose medium: AbstractLow-level laser therapy (LLLT) exhibited biostimulatory effects on fibroblasts viability. Secretomes can be administered to culture mediums by using bone marrow mesenchymal stem cells conditioned medium (BM-MSCs CM). This study investigated the combined effects of LLLT and human bone marrow mesenchymal stem cell conditioned medium (hBM-MSCs CM) on the cellular viability of human dermal fibrobla... περισσότερα »
Treatment of primary cutaneous amyloidosis with laser
Treatment of primary cutaneous amyloidosis with laser: a review of the literature: AbstractPrimary cutaneous amyloidosis (PCA) is a condition characterized by tissue deposition of misfolded proteins. PCA can present in different forms, namely macular, lichen, and nodular amyloidosis. These lesions can be of cosmetic concern and are difficult to treat. Many therapeutic modalities have been suggested for the treatment of PCA, with variable efficacy, including topical and systemic medications, phototherapy, electrodessication, dermabrasion, cryosurgery, and lasers. Over the past deca... περισσότερα »
Efficacy of fractional CO 2 laser in treatment of atrophic scar of cutaneous leishmaniasis
Efficacy of fractional CO 2 laser in treatment of atrophic scar of cutaneous leishmaniasis: AbstractCutaneous leishmaniasis is an endemic disease in Iran. Unfortunately, it can lead to unsightly atrophic scars with limited treatment options. Fractional CO2 laser is accepted for treatment of atrophic acne scars and recently has been used to treat cutaneous leishmaniasis, so we planned to use fractional CO2 laser on leishmaniasis scar. We conducted this study on 60 leishmaniasis scars on the face of 40 patients. The lesions were treated by a fractional CO2 laser with beam size of 12...περισσότερα »
Palatal fibroblasts reduce osteoclastogenesis in murine bone marrow cultures
Palatal fibroblasts reduce osteoclastogenesis in murine bone marrow cultures: Abstract BackgroundPreclinical studies support the assumption that connective tissue grafts preserve the alveolar bone from resorption; the underlying cellular mechanisms, however, remain unknown. The cellular mechanisms may be attributed to the paracrine activity of the palatal fibroblasts. It was thus reasonable to suggest that palatal connective tissue grafts reduce the formation of osteoclasts. MethodsTo test this hypothesis, human palatal fibroblasts were examined for their capacity to modulate ... περισσότερα »
Magnetic permeability as a predictor of the artefact size caused by orthodontic appliances at 1.5 T magnetic resonance imaging
Magnetic permeability as a predictor of the artefact size caused by orthodontic appliances at 1.5 T magnetic resonance imaging: Abstract ObjectivesArtefacts caused by orthodontic attachments limit the diagnostic value and lead to removal of these appliances before magnetic resonance imaging. Magnetic permeability can predict the artefact size. There is no standardised approach to determine the permeability of such attachments. The aim was to establish a reliable approach to determine artefact size caused by orthodontic attachments at 1.5 T MRI. Materials and methodsArtefact rad... περισσότερα »
Screening tests for predicting the prognosis of oral intake in elderly patients with acute pneumonia
Screening tests for predicting the prognosis of oral intake in elderly patients with acute pneumonia: AbstractMany elderly patients with pneumonia have aspiration pneumonia. Therefore they must temporarily abstain from oral intake. However, it is difficult to predict whether or not they will be able to start oral intake. The reason is the standard method to evaluate deglutition about pneumonia patients has not been established. In this study we aimed to develop a simple and convenient method that predicts the prognosis of oral intake as nutrition among elderly patients with acute s... περισσότερα »
Near infrared fluorescent nanoparticles based on hyaluronic acid
: self-assembly, optical properties, and cell interaction via Acta Biomaterialia Publication date: Available online 17 March 2016 *Source:*Acta Biomaterialia Author(s): Sneha S. Kelkar, Tanner K. Hill, Frank C. Marini, Aaron M. Mohs Fluorescent imaging agents that can specifically highlight tumor cells could have a significant impact on image-guided tumor removal. Here, fluorescent nanoparticles (NPs) derived from hyaluronic acid (HA) are investigated. HA is a ligand for the receptor CD44, which is a common biomarker present on many primary tumor cells, cancer-initiating cells, and tum... περισσότερα »
Pseudomonas aeruginosa : Synergy between Tobramycin and Trivalent Chromium Ion
Synergy between Tobramycin and Trivalent Chromium Ion in Electrochemical Control of Pseudomonas aeruginosa via Acta Biomaterialia Publication date: Available online 17 March 2016 *Source:*Acta Biomaterialia Author(s): Tagbo H.R. Niepa, Hao Wang, James C. Dabrowiak, Jeremy L. Gilbert, Dacheng Ren We recently demonstrated that the effectiveness of tobramycin (Tob), an aminoglycoside, against antibiotic-tolerant persister cells of Pseudomonas aeruginosa can be enhanced by electrochemical factors generated from direct currents (DC). Supplementation of Ni(II), Cr(III) and Fe(II) during car... περισσότερα »
Risk of second primary malignancies among 1537 melanoma patients and risk of second primary melanoma among 52 354 cancer patients in Northern Italy
Abstract Background The number of melanoma survivors has been increasing for decades due to early diagnosis and improved survival. These patients have an increased risk of developing a second primary cancer (SPC); also, melanoma is frequently diagnosed among patients firstly diagnosed with an extracutaneous malignancy. Objective We evaluated the risk of developing a SPC among 1537 melanoma patients, and the risk of second primary melanoma (SPM) in 52 354 extracutaneous cancer patients, who were treated at the European Institute of Oncology in Milan, Italy, during 2000–2010. Mate... περισσότερα »
Development and maturation of the auditory system depends substantially on the afferent activity supplying inputs to the developing centers
The effect of noise exposure during the developmental period on the function of the auditory system via Hearing Research [image: alertIcon.gif] Publication date: Available online 16 March 2016 *Source:*Hearing Research Author(s): Zbyněk Bureš, Jiří Popelář, Josef Syka Recently, there has been growing evidence that development and maturation of the auditory system depends substantially on the afferent activity supplying inputs to the developing centers. In cases when this activity is altered during early ontogeny as a consequence of, e.g., an unnatural acoustic environment or acoustic t... περισσότερα »
Three-Dimensionally Printed Tympanic Membrane Grafts
Design, Fabrication, and In Vitro Testing of Novel via Hearing Research [image: S03785955.gif] Publication date: Available online 16 March 2016 *Source:*Hearing Research Author(s): Elliott D. Kozin, Nicole L. Black, Jeffrey T. Cheng, Max J. Cotler, Michael J. McKenna, Daniel J. Lee, Jennifer A. Lewis, John J. Rosowski, Aaron K. Remenschneider The tympanic membrane (TM) is an exquisite structure that captures and transmits sound from the environment to the ossicular chain of the middle ear. The creation of TM grafts by multi-material three-dimensional (3D) printing may overcome limit... περισσότερα »
Auditory steady-state responses in cochlear implant users
: effect of modulation frequency and stimulation artifacts via Hearing Research [image: S03785955.gif] Publication date: Available online 17 March 2016 *Source:*Hearing Research Author(s): Robin Gransier, Hanne Deprez, Michael Hofmann, Marc Moonen, Astrid van Wieringen, Jan Wouters Previous studies have shown that objective measures based on stimulation with low-rate pulse trains fail to predict the threshold levels of cochlear implant (CI) users for high-rate pulse trains, as used in clinical devices. Electrically evoked auditory steady-state responses (EASSRs) can be elicited by mo... περισσότερα »
Usefulness of Housekeeping Genes for the Diagnosis of Helicobacter pylori Infection, Strain Discrimination and Detection of Multiple Infection
Abstract Background *Helicobacter pylori* infects human stomachs of over half the world's population, evades the immune response and establishes a chronic infection. Although most people remains asymptomatic, duodenal and gastric ulcers, MALT lymphoma and progression to gastric cancer could be developed. Several virulence factors such as flagella, lipopolysaccharide, adhesins and especially the vacuolating cytotoxin VacA and the oncoprotein CagA have been described for *H. pylori*. Despite the extensive published data on *H. pylori*, more research is needed to determine new virule...περισσότερα »
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Svetlana Ulyanchenko, Kathy E. O’Neill, Tanya Medley, Alison M. Farley, Harsh J. Vaidya, Alistair M. Cook, Natalie F. Blair, C. Clare Blackburn Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, […]
α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Shangang Zhao, Yves Mugabo, Gwynne Ballentine, Camille Attane, Jose Iglesias, Pegah Poursharifi, Dongwei Zhang, Thuy Anne Nguyen, Heidi Erb, Raphael Prentki, Marie-Line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju, Marc Prentki Suppression of α/β-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG) […]
Alternative Splicing of G9a Regulates Neuronal Differentiation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Ana Fiszbein, Luciana E. Giono, Ana Quaglino, Bruno G. Berardino, Lorena Sigaut, Catalina von Bilderling, Ignacio E. Schor, Juliana H. Enriqué Steinberg, Mario Rossi, Lía I. Pietrasanta, Julio J. Caramelo, Anabella Srebrow, Alberto R. Kornblihtt Chromatin modifications are critical for the establishment and maintenance of […]
Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 12 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): En-Ju Chou, Liang-Yi Hung, Chieh-Ju C. Tang, Wen-Bin Hsu, Hsin-Yi Wu, Pao-Chi Liao, Tang K. Tang CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through […]
Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Miryoung Song, Ju-Sim Kim, Lin Liu, Maroof Husain, Andrés Vázquez-Torres The thiol-disulfide oxidoreductase CXXC catalytic domain of thioredoxin contributes to antioxidant defense in phylogenetically diverse organisms. We find that although the oxidoreductase activity of thioredoxin-1 protects Salmonella enterica serovar Typhimurium from hydrogen peroxide in vitro, […]
Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Petter Säwén, Stefan Lang, Pankaj Mandal, Derrick J. Rossi, Shamit Soneji, David Bryder Homeostasis of short-lived blood cells is dependent on rapid proliferation of immature precursors. Using a conditional histone 2B-mCherry-labeling mouse model, we characterize hematopoietic stem cell (HSC) and progenitor proliferation dynamics in steady […]
Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Hiroki Hikasa, Yoshitaka Sekido, Akira Suzuki Contact inhibition of proliferation is critical for tissue organization, and its dysregulation contributes to tumorigenesis. Merlin/NF2 is a tumor suppressor that governs contact inhibition. Although Merlin/NF2 inhibits YAP1 and TAZ, which are paralogous Hippo pathway transcriptional co-activators and oncoproteins, […]
Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Harikesh S. Wong, Valentin Jaumouillé, Spencer A. Freeman, Sasha A. Doodnauth, Daniel Schlam, Johnathan Canton, Ilya M. Mukovozov, Amra Saric, Sergio Grinstein, Lisa A. Robinson Excessive uptake of oxidized low-density lipoproteins (oxLDL) by macrophages is a fundamental characteristic of atherosclerosis. However, signals regulating the engagement […]
Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash Kappa opioid receptors (KORs) are […]
Rapid Elevation in CMPF May Act As a Tipping Point in Diabetes Development
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 13 δευτερόλεπτα
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Ying Liu, Kacey J. Prentice, Judith A. Eversley, Cheng Hu, Battsetseg Batchuluun, Katherine Leavey, Jakob B. Hansen, David W. Wei, Brian Cox, Feihan F. Dai, Weiping Jia, Michael B. Wheeler Prediabetes, a state of mild glucose intolerance, can persist for years before a sudden decline […]
Floor impact noise in apartment buildings
Relationships between non-acoustic factors and subjective reactions to floor impact noise in apartment buildings: [image: cm_sbs_024_plain.png] The aim of this study was to provide an understanding of how residents in apartment buildings perceive and react to impact sounds coming from the upstairs neighbours' dwellings. Based on existing theoretical and empirical studies on environmental noise, a conceptual model was developed to explain relationships among noise annoyance and non-acoustic factors. The model was then tested using structural equation modelling with survey data from ... περισσότερα »
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant
Utility of bilateral acoustic hearing in combination with electrical stimulation provided by the cochlear implant: 10.3109/14992027.2016.1150609<br>Kerrie Plant Abstract *Objective*: The aim of the study was to quantify the benefit provided by having access to amplified acoustic hearing in the implanted ear for use in combination with contralateral acoustic hearing and the electrical stimulation provided by the cochlear implant. *Design*: Measures of spatial and non-spatial hearing abilities were obtained to compare performance obtained with different configurations of acoustic ...περισσότερα »
Relations Among Detection of Syllable Stress, Speech Abnormalities, and Communicative Ability in Adults With Autism Spectrum Disorders
Relations Among Detection of Syllable Stress, Speech Abnormalities, and Communicative Ability in Adults With Autism Spectrum Disorders: Purpose To date, the literature on perception of affective, pragmatic, and grammatical prosody abilities in autism spectrum disorders (ASD) has been sparse and contradictory. It is interesting to note that the primary perception of syllable stress within the word structure, which is crucial for all prosody functions, remains relatively unexplored in ASD. Thus, in the current study, we explored syllable stress perception sensitivity and its relation... περισσότερα »
Assessing Measurement Invariance for Sentence Repetition and Morphology Elicitation Tasks
Assessing Measurement Invariance for Spanish Sentence Repetition and Morphology Elicitation Tasks: Purpose The purpose of this study was to evaluate evidence supporting the construct validity of two grammatical tasks (sentence repetition, morphology elicitation) included in the Spanish Screener for Language Impairment in Children (Restrepo, Gorin, & Gray, 2013). We evaluated if the tasks measured the targeted grammatical skills in the same way across predominantly Spanish-speaking children with typical language development and those with primary language impairment. Method A mult... περισσότερα »
Causal network analysis of head and neck keloid tissue identifies potential master regulators
Causal network analysis of head and neck keloid tissue identifies potential master regulators: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis To generate novel insights and hypotheses in keloid development from potential master regulators. Study Design Prospective cohort. Methods Six fresh keloid and six normal skin samples from 12 anonymous donors were used in a prospective cohort study. Genome-wide profiling was done previously on the cohort using the Infinium HumanMethylation450 BeadChip (Illumina, San Diego, CA). The 190 statistically significant CpG ... περισσότερα »
Three-dimensional manometry of the upper esophageal sphincter in swallowing and nonswallowing tasks
Three-dimensional manometry of the upper esophageal sphincter in swallowing and nonswallowing tasks: [image: cover.gif?v=1&s=91b5c09aa476055defd12367] Objectives/Hypothesis High-resolution manometry (HRM) is useful in identifying disordered swallowing patterns and quantifying pharyngeal and upper esophageal sphincter (UES) physiology. HRM is limited by unidirectional sensors and circumferential averaging of pressures, resulting in an imperfect understanding of pressure from asymmetrical pharyngeal anatomy. This study aims to evaluate UES pressures simultaneously from different a...περισσότερα »
Otolaryngologic Manifestations of Levamisole-Induced Vasculitis
Otolaryngologic Manifestations of Levamisole-Induced Vasculitis: [image: s_olo150009f1.png] This case report describes a rare instance of laryngeal involvement in levamisole-induced vasculitis. This case report describes a rare instance of laryngeal involvement in levamisole-induced vasculitis. Levamisole is a synthetic imidazothizole derivative that was introduced in the 1970s for the treatment of rheumatalogic conditions and cancer owing to its immunomodulatory effects.1Although withdrawn from the market in 2000 because of severe adverse reactions,2 levamisole is commonly f... περισσότερα »
Inpatient Tonsillectomy in Children 36 Months and Younger
Inpatient Tonsillectomy in Children 36 Months and Younger: This study assesses complications following inpatient extracapsular tonsillectomy in children. *Importance* Tonsillectomy is among the most common surgical procedures performed by general and pediatric otolaryngologists. Inpatient surgery is generally recommended for children 36 months and younger owing to concern for a higher incidence of postoperative complications. *Objective* To ascertain the need for a planned inpatient stay for extracapsular tonsillectomy in children 36 months and younger. *Design, Setting, and Par...περισσότερα »
Spontaneous hypothermia in human sepsis is a transient, self-limiting and non-terminal response.
Hypothermia in sepsis is generally perceived as something dysregulated and progressive, even though there has been no assessment on the natural course of this phenomenon in humans. This was the first study on the dynamics of hypothermia in septic patients not subjected to active rewarming, and the results were surprising. A sample of 50 subjects presenting spontaneous hypothermia during sepsis was drawn from the 2005-2012 database of an academic hospital. Hypothermia was defined as body temperature below 36.0ºC for longer than 2 h, with at least one reading of 35.5ºC or less. The ...περισσότερα »
Physiology in Medicine: Neuromuscular consequences of diabetic neuropathy
Diabetic polyneuropathy (DPN) refers to peripheral nerve dysfunction as a complication of diabetes mellitus. This condition is relatively common and is likely a result of vascular and/or metabolic disturbances related to diabetes. In the early or less severe stages of DPN it typically results in sensory impairments, but can eventually lead to major dysfunction of the neuromuscular system. Some of these impairments may include: muscle atrophy and weakness, slowing of muscle contraction, and loss of power and endurance. Combined with sensory deficits these changes in the motor system...περισσότερα »
Dilution space ratio of 2H and 18O of doubly labeled water method in humans
Variation of the dilution space ratio (Nd/No) between deuterium (2H) and oxygen-18 (18O) impacts the calculation of total energy expenditure (TEE) by doubly labeled water (DLW). Our aim was to examine the physiological and methodological sources of variation of Nd/No in humans. We analyzed data from 2297 humans (0.25-89 years old). This included the variables Nd/No, total body water, TEE, body mass index (BMI), and percent body fat (%fat). To differentiate between physiologic and methodologic sources of variation, the urine samples from 54 subjects were divided, blinded and analyze...περισσότερα »
INTESTINAL AND SUBLINGUAL MICROCIRCULATION ARE MORE SEVERELY COMPROMISED IN HEMODILUTION THAN IN HEMORRHAGE
The alterations in O2 extraction in hemodilution have been linked to fast red blood cell (RBC) velocity, which might affect the complete release of O2 from Hb. Fast RBC velocity might also explain the normal mucosal-arterial PCO2 (PCO2). Yet sublingual and intestinal microcirculation have not been completely characterized in extreme hemodilution. Our hypothesis was that the unchanged PCO2 in hemodilution depends on the preservation of villi microcirculation. For this purpose, pentobarbital-anesthetized and mechanically ventilated sheep were submitted to stepwise hemodilution (n=8)...περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs Christopher R. La... περισσότερα »
Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Svetlana Ulyanchenko, Kathy E. O’Neill, Tanya Medley, Alison M. Farley, Harsh J. Vaidya, Alistair M. Cook, Natalie F. Blair, C. Clare Blackburn Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here,… Continue reading Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus
Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma
Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma: This medical record review examines whether the CRTC1/MAML2 fusion transcript is associated with disease stage, tumor grade, and survival in patients with mucoepidermoid carcinoma. Importance The CRTC1/MAML2 fusion transcript, which arises from the CRTC1/MAML2translocation, is a molecular marker unique to mucoepidermoid carcinoma (MEC), the most common malignant tumor… Continue reading Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma
α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Shangang Zhao, Yves Mugabo, Gwynne Ballentine, Camille Attane, Jose Iglesias, Pegah Poursharifi, Dongwei Zhang, Thuy Anne Nguyen, Heidi Erb, Raphael Prentki, Marie-Line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju, Marc Prentki Suppression of α/β-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG)… Continue reading α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes
Slow-Growing Right Mandibular Mass
Slow-Growing Right Mandibular Mass: A young woman had progressive swelling along her right posterior mandible and discomfort with mastication; CT revealed a soft-tissue mass extending into the right retromolar trigone with loss of the intervening fat and soft-tissue planes. What is your diagnosis? from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XzvKbd… Continue reading Slow-Growing Right Mandibular Mass
Hypogeusia in Healthy Children
Hypogeusia in Healthy Children: This study examines the incidence of hypogeusia in a group of healthy children as well as correlations with sociodemographic and olfactory findings. Importance There are currently no measures of isolated glossopharyngeal taste in healthy children, to our knowledge. Objective To define the taste characteristics of an otherwise healthy pediatric population that… Continue reading Hypogeusia in Healthy Children
Alternative Splicing of G9a Regulates Neuronal Differentiation
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Ana Fiszbein, Luciana E. Giono, Ana Quaglino, Bruno G. Berardino, Lorena Sigaut, Catalina von Bilderling, Ignacio E. Schor, Juliana H. Enriqué Steinberg, Mario Rossi, Lía I. Pietrasanta, Julio J. Caramelo, Anabella Srebrow, Alberto R. Kornblihtt Chromatin modifications are critical for the establishment and maintenance of… Continue reading Alternative Splicing of G9a Regulates Neuronal Differentiation
Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): En-Ju Chou, Liang-Yi Hung, Chieh-Ju C. Tang, Wen-Bin Hsu, Hsin-Yi Wu, Pao-Chi Liao, Tang K. Tang CPAP is required for centriole elongation during S/G2 phase, but the role of CPAP in mitosis is incompletely understood. Here, we show that CPAP maintains spindle pole integrity through… Continue reading Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis
Change in Unknown Primary Squamous Cell Carcinoma
Change in Unknown Primary Squamous Cell Carcinoma: This study determines the frequency of unknown primary squamous cell carcinoma over time and evaluates the proportion of these carcinomas that are positive for human papillomavirus. Importance The presence of human papillomavirus (HPV) in unknown primary squamous cell carcinoma (UPSCC) of the head and neck at initial presentation… Continue reading Change in Unknown Primary Squamous Cell Carcinoma
Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity
Publication date: Available online 17 March 2016 Source:Cell Reports Author(s): Miryoung Song, Ju-Sim Kim, Lin Liu, Maroof Husain, Andrés Vázquez-Torres The thiol-disulfide oxidoreductase CXXC catalytic domain of thioredoxin contributes to antioxidant defense in phylogenetically diverse organisms. We find that although the oxidoreductase activity of thioredoxin-1 protects Salmonella enterica serovar Typhimurium from hydrogen peroxide in vitro,… Continue reading Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity
Mastoid Mass With Associated Pulmonary Cystic Lesions
Mastoid Mass With Associated Pulmonary Cystic Lesions: A young woman had otalgia, intermittent rotary vertigo, protrusion of the auricle, and mastoid erythema and tenderness; CT revealed an expansile mass in the mastoid cavity and multiple bilateral cystic lesions and reticular nodular densities. What is your diagnosis? from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis… Continue reading Mastoid Mass With Associated Pulmonary Cystic Lesions
Facial Swelling in an Infant
Facial Swelling in an Infant: [image: s_ocg150052f1.png] An infant presented with a 1-month history of recurrent, right-sided facial swelling with fever and nonbilious, nonbloody vomiting; the right side of her face was swollen from the infraorbital rim to the submandibular area. What is your diagnosis? [image: First page PDF preview]
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma
Ultrasound Characteristics and Metastatic Papillary Thyroid Carcinoma: This study evaluates the usefulness of preoperative ultrasound characteristics in predicting pathologic extranodal extension in patients with metastatic papillary thyroid carcinoma. *Importance* The presence of extranodal extension (ENE) in metastatic papillary thyroid carcinoma (PTC) has emerged as an important prognostic factor, independently associated with tumor persistence after initial resection, decreased likelihood of complete biochemical response, and worse cause-specific survival. Therefore, the abi... περισσότερα »
Persistent Temporal Bone Lesion After Vestibular Schwannoma Resection
Persistent Temporal Bone Lesion After Vestibular Schwannoma Resection: [image: s_ocg150053f1.png] Two years after a woman underwent a retrosigmoid approach for gross resection of a vestibular schwannoma, follow-up imaging revealed residual tumor growth and a region of enhancing tissue involving the left mastoid and jugular foramen. What is your diagnosis? [image: First page PDF preview]
Three-Dimensional Pediatric Endoscopy
Three-Dimensional Pediatric Endoscopy: This case series describes the pilot use of 3-dimensional endoscopy to facilitate supraglottoplasty and to assess outcomes in children with laryngomalacia. *Importance* The use of 3-dimensional (3D) endoscopy has been described in the pediatric airway and has been shown to improve visualization of complex airway anatomy. Laryngomalacia is one of the most common airway disorders evaluated in pediatric otolaryngology offices. Whether 3D visualization is superior to standard endoscopy as a means for assessment and surgical management of comple... περισσότερα »
Getting the Most From Cochlear Implants
Getting the Most From Cochlear Implants: [image: oic150003.pdf.gif] It is no longer true that cochlear implantation is considered successful if the device simply provides some access between a deaf person and the surrounding auditory world. Our expectations for implants have grown so much that we now aspire for them to create or restore normal or near-normal hearing. As binaural creatures, we intuitively grasp that this goal requires bilateral, rather than unilateral, implantation to achieve the same advantages of sound localization and improved hearing in noise that 2 ears pro... περισσότερα »
Comparison of Bilateral and Unilateral Cochlear Implantation in Adults
Comparison of Bilateral and Unilateral Cochlear Implantation in Adults: This clinical trial examines the benefits of simultaneous bilateral cochlear implantation compared with unilateral cochlear implantation in adults with postlingual deafness. *Importance* The cost of bilateral cochlear implantation (BCI) is usually not reimbursed by insurance companies because of a lack of well-designed studies reporting the benefits of a second cochlear implant. *Objective* To determine the benefits of simultaneous BCI compared with unilateral cochlear implantation (UCI) in adults with postl... περισσότερα »
Four-Duct Ligation for the Treatment of Sialorrhea in Children
Four-Duct Ligation for the Treatment of Sialorrhea in Children: This retrospective cohort study reports clinical outcomes of the 4-duct ligation procedure in a consecutive series of pediatric patients with sialorrhea and characterizes patient and caregiver satisfaction. *Importance* The 4-duct ligation procedure has appeal for its surgical simplicity and limited invasiveness in the management of pediatric sialorrhea. However, more information is required to understand the benefits, risks, success rates, and long-term effects of this intervention. *Objectives* To report the clini... περισσότερα »
Tracheostomy Placement in Children Younger Than 2 Years
Tracheostomy Placement in Children Younger Than 2 Years: This analysis of National Surgical Quality Improvement Program Pediatric data examines factors associated with complications following tracheostomy placement in patients younger than 2 years. *Importance* Analysis of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) Pediatric demonstrated that the highest contribution to composite morbidity in otolaryngology is seen in children younger than 2 years undergoing tracheostomy. *Objective* To determine predictive factors for complications fo...περισσότερα »
Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma
Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma: This medical record review examines whether the CRTC1/MAML2 fusion transcript is associated with disease stage, tumor grade, and survival in patients with mucoepidermoid carcinoma. *Importance* The *CRTC1/MAML2* fusion transcript, which arises from the *CRTC1/MAML2*translocation, is a molecular marker unique to mucoepidermoid carcinoma (MEC), the most common malignant tumor of the salivary gland. The extent to which the transcript influences disease features and patient survival is unclear. *Objective* To determine wh... περισσότερα »
Slow-Growing Right Mandibular Mass
Slow-Growing Right Mandibular Mass: [image: s_ocg150056f1.png] A young woman had progressive swelling along her right posterior mandible and discomfort with mastication; CT revealed a soft-tissue mass extending into the right retromolar trigone with loss of the intervening fat and soft-tissue planes. What is your diagnosis? [image: First page PDF preview]
Hypogeusia in Healthy Children
Hypogeusia in Healthy Children: This study examines the incidence of hypogeusia in a group of healthy children as well as correlations with sociodemographic and olfactory findings. *Importance* There are currently no measures of isolated glossopharyngeal taste in healthy children, to our knowledge. *Objective* To define the taste characteristics of an otherwise healthy pediatric population that could serve as a control group for further investigations. *Design, Setting, and Participants* A prospective study of taste and smell was conducted from August 4 to 29, 2014, at a genera... περισσότερα »
Change in Unknown Primary Squamous Cell Carcinoma
Change in Unknown Primary Squamous Cell Carcinoma: This study determines the frequency of unknown primary squamous cell carcinoma over time and evaluates the proportion of these carcinomas that are positive for human papillomavirus. *Importance* The presence of human papillomavirus (HPV) in unknown primary squamous cell carcinoma (UPSCC) of the head and neck at initial presentation focuses the investigation for the primary tumor on the oropharynx. The trends, frequency, and detection rate of UPSCCs have not been evaluated in the context of HPV tumor status. *Objectives* To dete... περισσότερα »
Mastoid Mass With Associated Pulmonary Cystic Lesions
Mastoid Mass With Associated Pulmonary Cystic Lesions: [image: s_ocg150054f1.png] A young woman had otalgia, intermittent rotary vertigo, protrusion of the auricle, and mastoid erythema and tenderness; CT revealed an expansile mass in the mastoid cavity and multiple bilateral cystic lesions and reticular nodular densities. What is your diagnosis? [image: First page PDF preview]
Pediatric Nasopharyngeal Carcinoma
Factors Associated With Mortality in Pediatric Nasopharyngeal Carcinoma: This cohort study uses data from the National Cancer Data Base to examine differences between pediatric and adult patients with nasopharyngeal carcinoma and whether race confers a survival difference among pediatric patients. *Importance* Nasopharyngeal carcinoma (NPC) is endemic in some Asian regions but is uncommon in the United States. Little is known about the racial, demographic, and biological characteristics of the disease in pediatric patients. *Objectives* To improve understanding of the differenc... περισσότερα »
Effect of head position on laryngeal visualisation with the McGrath MAC videolaryngoscope in paediatric patients: A randomised controlled trial.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
BACKGROUND: The McGrath MAC video laryngoscope can improve visualisation of the glottis compared with the Macintosh direct laryngoscope. However, good visualisation of the glottis does not guarantee rapid or successful intubation because of difficulty in handling the McGrath device. OBJECTIVE: We evaluated the effect of head elevation, aligning the positions of the external auditory meatus […]
Use of the modified Borg scale and numerical rating scale to measure chronic breathlessness: a pooled data analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
The subjective nature of the experience of chronic breathlessness (dyspnoea) creates challenges for patients who need to communicate its intensity, and for clinicians and researchers who need to measure the symptom in order to plan management and assess the effect of interventions. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1ps1ljX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos […]
Initial dual oral combination therapy in pulmonary arterial hypertension
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Treatment for pulmonary arterial hypertension (PAH) has been underpinned by single-agent therapy to which concomitant drugs are added sequentially when pre-defined treatment goals are not met. This retrospective analysis of real-world clinical data in 97 patients with newly diagnosed PAH (86% in New York Heart Association functional class III–IV) explored initial dual oral combination treatment […]
A comparison of COPD patients with and without ACOS in the ECLIPSE study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
There is growing interest in asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) [1, 2]. Yet, there is no consensus on the best definition of ACOS [1, 2] and, therefore, it is difficult to appropriately characterise these patients. Here, we compare the main clinical characteristics and outcomes of COPD patients with and without ACOS in […]
Incorporating therapeutic drug monitoring into the World Health Organization hierarchy of tuberculosis diagnostics
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Tuberculosis (TB), once considered as a disease of the past generally afflicting poor people, still claims 1.5 million lives annually [1]. Although 86% of patients with drug susceptible TB are cured with established first-line drugs, treatment is often longer than 6 months due to slow response, compliance problems or adverse drug reactions. In addition, emergence […]
Asthmatics with high levels of serum surfactant protein D have more severe disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Pulmonary surfactant is a mixture of lipids and surfactant-specific proteins that covers the alveolar surface, as well as the terminal conducting airways, lowering the surface tension at the air–liquid interface during breathing. The involvement of pulmonary surfactant in the pathophysiology of asthma has been suggested [1–4]. An interesting working hypothesis is that the surface tension […]
Airflow obstruction is associated with increased smooth muscle extracellular matrix
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Increased thickness of the airway smooth muscle (ASM) layer is a characteristic feature of airway remodelling in both asthma and chronic obstructive pulmonary disease (COPD) [1, 2]. The composition of the ASM layer has been well studied in asthma where the increased thickness of the ASM layer is due to hypertrophy and/or hyperplasia [3–5] of […]
Nutritional Status Based on Body Mass Index Is Associated With Morbidity and Mortality in Mechanically Ventilated Critically Ill Children in the PICU.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objective: To determine the influence of admission anthropometry on clinical outcomes in mechanically ventilated children in the PICU. Design: Data from two multicenter cohort studies were compiled to examine the unique contribution of nutritional status, defined by body mass index z score, to 60-day mortality, hospital-acquired infections, length of hospital stay, and ventilator-free days, using […]
Prediction of 60-Day Case Fatality After Aneurysmal Subarachnoid Hemorrhage: External Validation of a Prediction Model.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Objective: External validation of prognostic models is crucial but rarely done. Our aim was to externally validate a prognostic model to predict 60-day case fatality after aneurysmal subarachnoid hemorrhage developed from the International Subarachnoid Aneurysm Trial in a retrospective unselected cohort of subarachnoid hemorrhage patients. Design: The model’s predictors were age, aneurysm size, Fisher grade, […]
Optically responsive supramolecular polymer glasses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 42 δευτερόλεπτα
Article The ability to heal whilst maintaining original functionality is important for establishing materials with superior longevity. Here, the authors demonstrate a supramolecular polymeric coating which exhibits excellent optical and mechanical properties, even following damage repair. Nature Communications doi: 10.1038/ncomms10995 Authors: Diederik W. R. Balkenende, Christophe A. Monnier, Gina L. Fiore, Christoph Weder from #Medicine-SfakianakisAlexandros […]
Nutritional Status Based on Body Mass Index Is Associated With Morbidity and Mortality in Mechanically Ventilated Critically Ill Children in the PICU.
[image: wk-health-logo.gif] Objective: To determine the influence of admission anthropometry on clinical outcomes in mechanically ventilated children in the PICU. Design: Data from two multicenter cohort studies were compiled to examine the unique contribution of nutritional status, defined by body mass index z score, to 60-day mortality, hospital-acquired infections, length of hospital stay, and ventilator-free days, using multivariate analysis. Setting: Ninety PICUs from 16 countries with eight or more beds. Patients: Children aged 1 month to 18 years, admitted to each participat... περισσότερα »
Prediction of 60-Day Case Fatality After Aneurysmal Subarachnoid Hemorrhage: External Validation of a Prediction Model.
[image: wk-health-logo.gif] Objective: External validation of prognostic models is crucial but rarely done. Our aim was to externally validate a prognostic model to predict 60-day case fatality after aneurysmal subarachnoid hemorrhage developed from the International Subarachnoid Aneurysm Trial in a retrospective unselected cohort of subarachnoid hemorrhage patients. Design: The model's predictors were age, aneurysm size, Fisher grade, and World Federation of Neurological Surgeons grade. Two versions of the model were validated: one with World Federation of Neurological Surgeons gr...περισσότερα »
Telemedicine Provides Non-Inferior Research Informed Consent for Remote Study Enrollment: A Randomized Controlled Trial
[image: cover.gif?v=1&s=0c5d2eb0505474589c1ec653] Abstract Objective Telemedicine networks are beginning to provide an avenue for conducting emergency medicine research, but using telemedicine to recruit participants for clinical trials has not been validated. The goal of this consent study is to determine whether patient comprehension of telemedicine-enabled research informed consent is non-inferior to standard face-to-face research informed consent. Methods A prospective, open-label randomized controlled trial was performed in a 60,000-visit Midwestern academic Emergency Departm... περισσότερα »
Usefulness of Housekeeping Genes for the Diagnosis of Helicobacter pylori Infection, Strain Discrimination and Detection of Multiple Infection
Abstract Background *Helicobacter pylori* infects human stomachs of over half the world's population, evades the immune response and establishes a chronic infection. Although most people remains asymptomatic, duodenal and gastric ulcers, MALT lymphoma and progression to gastric cancer could be developed. Several virulence factors such as flagella, lipopolysaccharide, adhesins and especially the vacuolating cytotoxin VacA and the oncoprotein CagA have been described for *H. pylori*. Despite the extensive published data on *H. pylori*, more research is needed to determine new virule...περισσότερα »
Fluorescence Visualization–Guided Surgery for Early-Stage Oral Cancer
Fluorescence Visualization–Guided Surgery for Early-Stage Oral Cancer: This cohort study compares outcomes for patients with early-stage oral cancer who underwent fluorescence visualization–guided vs conventional surgery. *Importance* The prevalence of genetically altered cells in oral cancers has a negative influence on the locoregional recurrence rate and lowers survival. Fluorescence visualization (FV) can identify clinically occult, high-risk oral lesions by allowing health care professionals and surgeons to visualize and map occult disease. This process may improve overall ... περισσότερα »
Parapharyngeal Space Mass
Parapharyngeal Space Mass: An elderly man had a slowly enlarging left facial mass; nasopharyngoscopy revealed slight bulging of the lateral pharyngeal wall into the oropharynx and imaging showed a lesion arising from the left parapharyngeal space, arising from the deep lobe of the parotid gland. What is your diagnosis? [image: First page PDF preview]
Isolated Sphenoid Lesion
Isolated Sphenoid Lesion: A woman experienced dizziness and headache to the vertex with left retro-orbital irradiation; MRI revealed a concentric multistratified appearance of the sinus content, a hyperintense peripheral layer, crescent-shaped heterogeneous material, and a black oval area in the sinus. What is your diagnosis? [image: First page PDF preview]
A Highly Vascularized Supraglottic Neoplasm
A Highly Vascularized Supraglottic Neoplasm: A man had dysphagia, dry cough, foreign-body sensation, and dyspnea; bilateral hyperemia of the tonsillar area and posterior pharyngeal wall were noted, and fiber-optic laryngoscopy revealed a supraglottic lesion involving the free margin of the suprahyoid epiglottis. What is your diagnosis? [image: First page PDF preview]
Parotid Gland Sarcoidosis
Clinical Characteristics of Parotid Gland Sarcoidosis: This population-based study describes the epidemiologic features of parotid gland involvement in sarcoidosis, with an emphasis on clinical characteristics, in a geographically well-defined population. [image: First page PDF preview]
Cochlear Histopathologic Findings in Suppurative Labyrinthitis
Cochlear Histopathologic Findings in Suppurative Labyrinthitis: This study evaluates the effects of suppurative labyrinthitis on cochlear elements in archived human temporal bones. *Importance* Better understanding of the effects of suppurative labyrinthitis (SL) on cochlear elements will aid the development of new approaches to treat its sequelae and complications in the ear. *Objective* To quantitatively evaluate the effects of SL on cochlear elements in humans. *Design, Setting, and Participants* A comparative study was conducted at a tertiary academic medical center from Oc... περισσότερα »
Coblation Endoscopic Lingual Lightening for Obstructive Sleep Apnea
Coblation Endoscopic Lingual Lightening for Obstructive Sleep Apnea: This retrospective case-control study evaluates the clinical and polysomnographic outcomes of tongue base reduction using the coblation endoscopic lingual lightening procedure in multilevel surgery for obstructive sleep apnea. *Importance* Multilevel obstruction is involved in the pathogenesis of obstructive sleep apnea (OSA). Coblation endoscopic lingual lightening (CELL) is a variation of glossectomy to reduce tongue collapse and can be considered in the surgical management of adults with OSA. *Objective* To...περισσότερα »
Intratympanic Ciprofloxacin in Tympanostomy Tube Placement
Intratympanic Ciprofloxacin in Tympanostomy Tube Placement: These 2 randomized clinical trials investigate the safety and efficacy of a single-dose intratympanic, intraoperative, extended-release, thermosensitive, otic suspension of ciprofloxacin administered to children undergoing tympanostomy tube placement. *Importance* Otorrhea after tympanostomy tube placement (TTP) in children is common. Although not approved by the US Food and Drug Administration, antibiotic ear drops are routinely used intraoperatively and prescribed for multidose, multiday postoperative administration b...περισσότερα »
Thyroid Cancer : The recommendations of the 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer with regard to the use of imaging modalities for the detection of thyroid cancer and known or suspected thyroid nodules.
Thyroid Cancer: This Viewpoint addresses the recommendations of the 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer with regard to the use of imaging modalities for the detection of thyroid cancer and known or suspected thyroid nodules. [image: First page PDF preview]
Palinacousis secondary to brain damage from methotrexate
Palinacusia secundaria a daño cerebral por metotrexato via Acta Otorrinolaringológica Española Publication date: Available online 16 March 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Ana Sánchez-Martínez, José I. Benito-Orejas, Dulce M. Campos-Blanco, Darío Morais-Pérez [image: Sección coronal de la RM, en secuencia T2, que muestra lesiones hiperintensas en ...]
Leishmaniasis mucocutánea
Leishmaniasis mucocutánea via Acta Otorrinolaringológica Española Publication date: Available online 16 March 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Vania Novoa Juiz, Raquel Redondo Luciañez [image: Image for figure Figura 1]
Surgical treatment of substernal goiter
Surgical treatment of substernal goiter: An analysis of 44 cases: Substernal goiters are classified as primary or secondary intrathoracic goiters. Here, we report the diagnosis, symptoms, treatment, and postoperative complications of 44 substernal goiters (2 primary mediastinal goiter and 42 secondary mediastinal goiters). AbstractObjective Substernal goiters are classified as primary or secondary intrathoracic goiters. Here, we report the diagnosis, symptoms, treatment, and postoperative complications of 44 substernal goiters (2 primary mediastinal goiter and 42 secondary medias... περισσότερα »
New Drug Delivery Tool in Anaplastic Thyroid Cancer : Combined treatment with doxorubicin-loaded NBs and ESWs is a promising drug delivery tool for ATC treatment with the possibility of using lower doxorubicin doses and thus limiting its systemic side effects.
Doxorubicin-Loaded Nanobubbles Combined with Extracorporeal Shock Waves: Basis for a New Drug Delivery Tool in Anaplastic Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Francesca Marano,1* Monica Argenziano,2* Roberto Frairia,1 Aloe Adamini,1 Ornella Bosco,1 Letizia Rinella,1 Nicoletta Fortunati,3 Roberta Cavalli,2 and Maria Graziella Catalano1 1Department of Medical Sciences, University of Turin, Turin, Italy. 2Department of Drug Science and Technology, University of Turin, Turin, Italy. 3Oncological Endocrinology, AO Città della Salute e della Scienza di Torino, Tur...περισσότερα »
Usefulness of Housekeeping Genes for the Diagnosis of Helicobacter pylori Infection, Strain Discrimination and Detection of Multiple Infection
Usefulness of Housekeeping Genes for the Diagnosis of Helicobacter pylori Infection, Strain Discrimination and Detection of Multiple Infection: Abstract Background *Helicobacter pylori* infects human stomachs of over half the world's population, evades the immune response and establishes a chronic infection. Although most people remains asymptomatic, duodenal and gastric ulcers, MALT lymphoma and progression to gastric cancer could be developed. Several virulence factors such as flagella, lipopolysaccharide, adhesins and especially the vacuolating cytotoxin VacA and the oncoprotein ... περισσότερα »
Release of the Inferior Crus in Antihelix Plasty
Release of the Inferior Crus in Antihelix Plasty: Objective: Protruding ears with a hypoplastic antihelix often have poorly developed inferior crus. Publications on this topic until now have only dealt with absent inferior crus and have neglected its importance in everyday antihelix plasty. This article describes a new surgical technique to improve treatment of the antihelix. Methods: Patients with protruding upper third ears received either standard otoplasty with crus superior remodeling (ST) or the newly developed surgical procedure including crus inferior release (STI). To eval... περισσότερα »
Loss of Mitochondrial Function Impairs Lysosomes Molecular Bases of Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Alterations in mitochondrial function, as observed in neurodegenerative diseases, lead to disrupted energy metabolism and production of damaging reactive oxygen species. Here, we demonstrate that mitochondrial dysfunction also disrupts the structure and function of lysosomes, the main degradation and recycling organelle. Specifically, inhibition of mitochondrial function, following deletion of the mitochondrial proteins AIF, OPA1 or […]
Airway Foreign Body Management: Negative Bronchoscopies
A Five-Year Analysis of Airway Foreign Body Management: Toward a Better Understanding of Negative Bronchoscopies: Objective: To identify characteristics in patients who undergo positive and negative bronchoscopy for a suspected airway foreign body (AFB). Methods: Review medical records between 2008 and 2012. Results: There were 145 patients who went to the operating room with the pre-bronchoscopy diagnosis of suspected AFB during the study period. There was an overall negative bronchoscopy rate of an average of 37%, with an annual range between 21% and 50%. The findings of history...περισσότερα »
Shaping prestimulus neural activity with auditory rhythmic stimulation improves the temporal allocation of attention.
Human attention fluctuates across time, and even when stimuli have identical physical characteristics and the task demands are the same, relevant information is sometimes consciously perceived and at other times not. A typical example of this phenomenon is the attentional blink, where participants show a robust deficit in reporting the second of two targets (T2) in a rapid serial visual presentation (RSVP) stream. Previous electroencephalographical (EEG) studies showed that neural correlates of correct T2 report are not limited to the RSVP period, but extend before visual stimulatio... περισσότερα »
Spectrum of Clinical and Associated MR Imaging Findings in Children with Olfactory Anomalies [HEAD & NECK]
BACKGROUND AND PURPOSE: The olfactory apparatus, consisting of the bulb and tract, is readily identifiable on MR imaging. Anomalous development of the olfactory apparatus may be the harbinger of anomalies of the secondary olfactory cortex and associated structures. We report a large single-site series of associated MR imaging findings in patients with olfactory anomalies. MATERIALS AND METHODS: A retrospective search of radiologic reports (2010 through 2014) was performed by using the keyword "olfactory"; MR imaging studies were reviewed for olfactory anomalies and intracranial ...περισσότερα »
A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth [PEDIATRICS]
BACKGROUND AND PURPOSE: Preterm neonates are at risk for neurodevelopmental impairment, but reliable, bedside-available markers to monitor preterm brain growth during hospital stay are still lacking. The aim of this study was to assess the feasibility of corpus callosum–fastigium length as a new cranial sonography marker for monitoring of preterm brain growth. MATERIALS AND METHODS: In this longitudinal prospective cohort study, cranial ultrasound was planned on the day of birth, days 1, 2, 3, and 7 of life; and then weekly until discharge in preterm infants born before 29 weeks...περισσότερα »
Whole-Brain DTI Assessment of White Matter Damage in Children with Bilateral Cerebral Palsy: Evidence of Involvement beyond the Primary Target of the Anoxic Insult [PEDIATRICS]
BACKGROUND AND PURPOSE: Cerebral palsy is frequently associated with both motor and nonmotor symptoms. DTI can characterize the damage at the level of motor tracts but provides less consistent results in nonmotor areas. We used a standardized pipeline of analysis to describe and quantify the pattern of DTI white matter abnormalities of the whole brain in a group of children with chronic bilateral cerebral palsy and periventricular leukomalacia. We also explored potential correlations between DTI and clinical scale metrics. MATERIALS AND METHODS: Twenty-five patients (mean age, 1...περισσότερα »
T1-Weighted Dynamic Contrast-Enhanced MRI Is a Noninvasive Marker of Epidermal Growth Factor Receptor vIII Status in Cancer Stem Cell--Derived Experimental Glioblastomas [LETTERS]
from Neurology via xlomafota13 on Inoreader http://ift.tt/1UFnmaR via IFTTT
Reduction of Oxygen-Induced CSF Hyperintensity on FLAIR MR Images in Sedated Children: Usefulness of Magnetization-Prepared FLAIR Imaging [PEDIATRICS]
BACKGROUND AND PURPOSE: Oxygen-induced CSF hyperintensity on FLAIR MR imaging is often observed in sedated children. This phenomenon can mimic leptomeningeal pathology and lead to a misdiagnosis. The purpose of this study was to investigate whether magnetization-prepared FLAIR MR imaging can reduce oxygen-induced CSF hyperintensity and improve image quality compared with conventional (non-magnetization-prepared) FLAIR MR imaging. MATERIALS AND METHODS: Bloch simulation for magnetization-prepared and non-magnetization-prepared FLAIR sequences was performed for tissue contrast. We... περισσότερα »
Expanding access to high-cost medicines through the E2 access program in Thailand: effects on utilisation, health outcomes and cost using an interrupted time-series analysis
Objective In 2008, the Thai government introduced the ‘high-cost medicines E2 access program’ as a part of the National List of Essential Medicines to increase patient access to medicines, improve clinical outcomes and make medicines more affordable. Our objective was to examine whether the ‘high-cost medicines E2 access program’ achieved its goals. Design Interrupted time-series… Continue reading Expanding access to high-cost medicines through the E2 access program in Thailand: effects on utilisation, health outcomes and cost using an interrupted time-series analysis
Understanding tensions and identifying clinician agreement on improvements to early-stage chronic kidney disease monitoring in primary care: a qualitative study
Objectives Since 2006, general practitioners (GPs) in England, UK, have been incentivised to keep a register and monitor patients with chronic kidney disease (CKD) stages 3–5. Despite tensions and debate around the merit of this activity, there has been little qualitative research exploring clinician perspectives on monitoring early-stage CKD in primary care. This study aimed… Continue reading Understanding tensions and identifying clinician agreement on improvements to early-stage chronic kidney disease monitoring in primary care: a qualitative study
Effects of Different Combinations of Er:YAG Laser-Adhesives on Enamel Demineralization and Bracket Bond Strength
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1S7vUFc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z7MyHy via IFTTT
Calling The Clock: Kruse Cock Up; Kanit Killing it; And More – CalvinAyre.com
CalvinAyre.com Calling The Clock: Kruse Cock Up; Kanit Killing it; And More CalvinAyre.com Last week, the WSOP and the One Drop Foundation joined forces to offer a unique auction where the winner would hold the mic, and let those words roll off their tongue, before the 2016 WSOP Main Event final table. Experts believe the… Continue reading Calling The Clock: Kruse Cock Up; Kanit Killing it; And More – CalvinAyre.com
Effects of Different Combinations of Er:YAG Laser-Adhesives on Enamel Demineralization and Bracket Bond Strength
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1Z7KaRi via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ViaBn7 via IFTTT
List of Reviewers
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1pPyUNi via IFTTT
Environmental layout complexity affects neural activity during navigation in humans
Abstract Navigating large-scale surroundings is a fundamental ability. In humans, it is commonly assumed that navigational performance is affected by individual differences, such as age, sex, and cognitive strategies adopted for orientation. We recently showed that the layout of the environment itself also influences how well people are able to find their way within it,… Continue reading Environmental layout complexity affects neural activity during navigation in humans
Issue Information – Journal Information
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RSlSoK via IFTTT
The ventromedial hypothalamus mediates predator fear memory
Abstract The amygdala has been shown to be essential for the processing of acute and learned fear across animal species. However, the downstream neural circuits that mediate these fear responses differ depending on the nature of the threat, with separate pathways identified for predator, conspecific, and physically harmful threats. In particular, the dorsomedial part of… Continue reading The ventromedial hypothalamus mediates predator fear memory
Corrigendum
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A Diffusion Tensor Imaging Study on White Matter Abnormalities in Patients with Type 2 Diabetes Using Tract-Based Spatial Statistics [ADULT BRAIN]
BACKGROUND AND PURPOSE: Patients with type 2 diabetes mellitus have considerably higher risk of developing cognitive impairment and dementia. WM changes in these patients have been reported. Our aim was to demonstrate that gradual and continuous WM change and the associated cognitive decline in patients with type 2 diabetes mellitus can be captured by DTI parameters, which can be used to complement neuropsychological test scores in identifying patients with type 2 diabetes mellitus with and without mild cognitive impairment. MATERIALS AND METHODS: Forty-two patients with type 2 ... περισσότερα »
Multimodal CT Imaging: Time to Treatment and Outcomes in the IMS III Trial [ADULT BRAIN]
BACKGROUND AND PURPOSE: The importance of time in acute stroke is well-established. Using the Interventional Management of Stroke III trial data, we explored the effect of multimodal imaging (CT perfusion and/or CT angiography) versus noncontrast CT alone on time to treatment and outcomes. MATERIALS AND METHODS: We examined 3 groups: 1) subjects with baseline CTP and CTA (CTP+CTA), 2) subjects with baseline CTA without CTP (CTA), and 3) subjects with noncontrast head CT alone. The demographics, treatment time intervals, and clinical outcomes in these groups were studied. RESULTS... περισσότερα »
Brain Injury in Neonates with Complex Congenital Heart Disease: What Is the Predictive Value of MRI in the Fetal Period? [PEDIATRICS]
BACKGROUND AND PURPOSE: Brain injury in neonates with congenital heart disease is an important predictor of adverse neurodevelopmental outcome. Impaired brain development in congenital heart disease may have a prenatal origin, but the sensitivity and specificity of fetal brain MR imaging for predicting neonatal brain lesions are currently unknown. We sought to determine the value of conventional fetal MR imaging for predicting abnormal findings on neonatal preoperative MR imaging in neonates with complex congenital heart disease. MATERIALS AND METHODS: MR imaging studies were pe...περισσότερα »
Improving Perfusion Measurement in DSC-MR Imaging with Multiecho Information for Arterial Input Function Determination [FUNCTIONAL]
BACKGROUND AND PURPOSE: Clinical measurements of cerebral perfusion have been increasingly performed with multiecho dynamic susceptibility contrast–MR imaging techniques due to their ability to remove confounding T1 effects of contrast agent extravasation from perfusion quantification. However, to this point, the extra information provided by multiecho techniques has not been used to improve the process of estimating the arterial input function, which is critical to accurate perfusion quantification. The purpose of this study is to investigate methods by which multiecho DSC-MRI d... περισσότερα »
Effects of Different Combinations of Er:YAG Laser-Adhesives on Enamel Demineralization and Bracket Bond Strength
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Effects of Different Combinations of Er:YAG Laser-Adhesives on Enamel Demineralization and Bracket Bond Strength
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Fingermark age determinations: legal considerations, review of the literature and practical propositions
Fingermarks have been used for more than a century for identification purposes during investigations and as evidence in court [1–3]. While the use of such marks for identification generally creates a strong link between a location or object and a person, there are no validated scientific methods for accurately determining the time of contact between… Continue reading Fingermark age determinations: legal considerations, review of the literature and practical propositions
Isoflurane versus desflurane: hemodynamic parameters and recovery characteristics: a comparative study
Aktham A Shoukry, Ayman Abd Laltif, Amr Abd Fattah, Ibrahim Abd Ghani, Mohamed Serag Ain-Shams Journal of Anaesthesiology 2016 9(1):45-51 Introduction Inhaled volatile anesthetics remain the most widely used drugs for maintenance of general anesthesia because of their ease of administration and predictable intraoperative and recovery characteristics. Management of hemodynamic stability and early recovery is… Continue reading Isoflurane versus desflurane: hemodynamic parameters and recovery characteristics: a comparative study
Correspondence Global platform to inform investments for health R&D
Investments in health research and development (R&D) are still insufficiently aligned with global public health demands and needs. As little as 1% of all global funding for health R&D is allocated to diseases mostly noted in low-income and middle-income countries, such as malaria and tuberculosis,1 even though these diseases account for more than 12·5% of… Continue reading Correspondence Global platform to inform investments for health R&D
Comment Defining new standards of care for men with prostate cancer
Improving the outcomes of medical or surgical castration for men with prostate cancer has been an elusive goal since the approach was first reported in the 1940s.1 However, this situation changed at the annual American Society of Clinical Oncology meeting in 2014, when results reported from the ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for… Continue reading Comment Defining new standards of care for men with prostate cancer
Editorial Addressing the social determinants of health in young people
On March 15, WHO’s Regional Office for Europe released Growing up unequal: gender and socioeconomic differences in young people’s health and well-being—their latest report from the Health Behaviour in School-aged Children (HBSC) study. The report includes self-reported survey data for 2013–14 from adolescents in 42 countries in Europe and North America. There is good news:… Continue reading Editorial Addressing the social determinants of health in young people
Does nebulized dexamethasone decrease the incidence of postextubation sore throat?: a randomized controlled study
Atef K Salama, Ahmed M El-badawy Ain-Shams Journal of Anaesthesiology 2016 9(1):104-107 Objective and aim of study Postoperative sore throat (POST) is a common complaint in about 21-65% of patients undergoing general anesthesia with endotracheal intubation. The aim of this randomized controlled study was to evaluate the efficacy of preoperative nebulized dexamethasone in decreasing the… Continue reading Does nebulized dexamethasone decrease the incidence of postextubation sore throat?: a randomized controlled study
Comment Defining new standards of care for men with prostate cancer
Improving the outcomes of medical or surgical castration for men with prostate cancer has been an elusive goal since the approach was first reported in the 1940s.1 However, this situation changed at the annual American Society of Clinical Oncology meeting in 2014, when results reported from the ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for… Continue reading Comment Defining new standards of care for men with prostate cancer
Editorial Addressing the social determinants of health in young people
On March 15, WHO’s Regional Office for Europe released Growing up unequal: gender and socioeconomic differences in young people’s health and well-being—their latest report from the Health Behaviour in School-aged Children (HBSC) study. The report includes self-reported survey data for 2013–14 from adolescents in 42 countries in Europe and North America. There is good news:… Continue reading Editorial Addressing the social determinants of health in young people
Editorial Unite to end tuberculosis
March 24 marks World TB Day. This year, the theme is “Unite to end tuberculosis”. WHO calls on governments, civil society, and the private sector to unite to end the tuberculosis epidemic—a much needed approach to tackle this deadliest of diseases. Although 43 million lives were saved through effective diagnosis and treatment between 2000 and… Continue reading Editorial Unite to end tuberculosis
Correspondence Global platform to inform investments for health R&D
Investments in health research and development (R&D) are still insufficiently aligned with global public health demands and needs. As little as 1% of all global funding for health R&D is allocated to diseases mostly noted in low-income and middle-income countries, such as malaria and tuberculosis,1 even though these diseases account for more than 12·5% of… Continue reading Correspondence Global platform to inform investments for health R&D
Corrigendum
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List of Reviewers
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Issue Information - Journal Information
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Issue Information - TOC
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Environmental layout complexity affects neural activity during navigation in humans
Abstract Navigating large-scale surroundings is a fundamental ability. In humans, it is commonly assumed that navigational performance is affected by individual differences, such as age, sex, and cognitive strategies adopted for orientation. We recently showed that the layout of the environment itself also influences how well people are able to find their way within it, yet it remains unclear whether differences in environmental complexity are associated with changes in brain activity during navigation. We used functional magnetic resonance imaging to investigate how the brain resp... περισσότερα »
The ventromedial hypothalamus mediates predator fear memory
Abstract The amygdala has been shown to be essential for the processing of acute and learned fear across animal species. However, the downstream neural circuits that mediate these fear responses differ depending on the nature of the threat, with separate pathways identified for predator, conspecific, and physically harmful threats. In particular, the dorsomedial part of the ventromedial hypothalamus (VHMdm) is critical for the expression of defensive responses to predator. Here, we tested the hypothesis that this circuit also participates in predator fear memory by transient pharm... περισσότερα »
Unmasking the linear behavior of slow motor adaptation to prolonged convergence
Abstract Adaptation to changing environmental demands is central to maintaining optimal motor system function. Current theories suggest that adaptation in both the skeletal-motor and oculomotor systems involves a combination of fast (reflexive) and slow (recalibration) mechanisms. Here we used the oculomotor vergence system as a model to investigate the mechanisms underlying slow motor adaptation. Unlike reaching with the upper limbs, vergence is less susceptible to changes in cognitive strategy that can affect the behaviour of motor adaptation. We tested the hypothesis that mecha...περισσότερα »
Evidence that some long-lasting effects of direct current in the rat spinal cord are activity-independent
Abstract *Effects of trans-spinal direct current stimulation (tsDCS) on specific neuronal populations are difficult to elucidate as it affects a variety of neuronal networks.* However, facilitatory and depressive effects on neurons processing information from the skin and from muscles *can* be evaluated separately when applying weak *(0.2-0.3 μA) direct current (DC)* within restricted areas of the rat spinal cord. Effects of such local DC were recently demonstrated to persist for at least an hour and to include changes in the excitability of afferent fibres as well as in their syna... περισσότερα »
Effects of Different Combinations of Er:YAG Laser-Adhesives on Enamel Demineralization and Bracket Bond Strength
Photomedicine and Laser Surgery , Vol. 0, No. 0. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1pPwD4R via IFTTT
Functional magnetic resonance imaging of internet addiction in young adults.
Related Articles *Functional magnetic resonance imaging of internet addiction in young adults.* World J Radiol. 2016 Feb 28;8(2):210-25 Authors: Sepede G, Tavino M, Santacroce R, Fiori F, Salerno RM, Di Giannantonio M Abstract AIM: To report the results of functional magnetic resonance imaging (fMRI) studies pertaining internet addiction disorder (IAD) in young adults. METHODS: We conducted a systematic review on PubMed, focusing our attention on fMRI studies involving adult IAD patients, free from any comorbid psychiatric condition. The following search words were used, both alo...περισσότερα »
Comparisons between glucose analogue 2-deoxy-2-((18)F)fluoro-D-glucose and (18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions.
Related Articles *Comparisons between glucose analogue 2-deoxy-2-((18)F)fluoro-D-glucose and (18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions.* World J Radiol. 2016 Feb 28;8(2):200-9 Authors: Capitanio S, Bongioanni F, Piccardo A, Campus C, Gonella R, Tixi L, Naseri M, Pennone M, Altrinetti V, Buschiazzo A, Bossert I, Fiz F, Bruno A, DeCensi A, Sambuceti G, Morbelli S Abstract AIM: To compare 2-deoxy-2-((18)F)fluoro-D-glucose((18)F-FDG) and (18)F-sodium ((18)F-NaF) positron emission tomography/computed tomography ... περισσότερα »
Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study.
Related Articles *Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study.* World J Radiol. 2016 Feb 28;8(2):192-9 Authors: Pearson WG, Davidoff AA, Smith ZM, Adams DE, Langmore SE Abstract AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer (rtHNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, videofluoroscopic images of rtHNC patients (n = 21) were compared with age and gender matched cont... περισσότερα »
Xanthogranulomatous cholecystitis: What every radiologist should know.
Related Articles *Xanthogranulomatous cholecystitis: What every radiologist should know.* World J Radiol. 2016 Feb 28;8(2):183-91 Authors: Singh VP, Rajesh S, Bihari C, Desai SN, Pargewar SS, Arora A Abstract Xanthogranulomatous cholecystitis (XGC) is an uncommon variant of chronic cholecystitis characterized by xanthogranulomatous inflammation of the gallbladder. Intramural accumulation of lipid-laden macrophages and acute and chronic inflammatory cells is the hallmark of the disease. The xanthogranulomatous inflammation of the gallbladder can be very severe and can spill over t...περισσότερα »
Benign neck masses showing restricted diffusion: Is there a histological basis for discordant behavior?
Related Articles *Benign neck masses showing restricted diffusion: Is there a histological basis for discordant behavior?* World J Radiol. 2016 Feb 28;8(2):174-82 Authors: Das A, Bhalla AS, Sharma R, Kumar A, Sharma M, Gamanagatti S, Thakar A, Sharma S Abstract Diffusion weighted imaging (DWI) evolved as a complementary tool to morphologic imaging by offering additional functional information about lesions. Although the technique utilizes movement of water molecules to characterize biological tissues in terms of their cellularity, there are other factors related to the histologi... περισσότερα »
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