NRASQ61R Protein in Follicular-patterned Thyroid Tumors
Immunohistochemical Detection of via Human Pathology Publication date: Available online 5 March 2016 *Source:*Human Pathology Author(s): Naoki Oishi, Tetsuo Kondo, Huy Gia Vuong, Tadao Nakazawa, Kunio Mochizuki, Kazunari Kasai, Tomohiro Inoue, Ippei Tahara, Mitsuyoshi Hirokawa, Akira Miyauchi, Ryohei Katoh The NRASA182G mutation, which results in the NRASQ61R protein, is a major driver mutation in follicular-patterned thyroid neoplasms. Although new immunohistochemistry (IHC) for NRASQ61R is now available, its sensitivity, specificity and diagnostic utility for thyroid tumors are not ... περισσότερα »
Intranasal (i.n.) administration of midazolam has been shown to be effective and safe for its sedative, anxiolytic, and anticonvulsant effects
Intranasal midazolam administration enhances amnesic effect in rats: AbstractIntranasal (i.n.) administration of midazolam has been shown to be effective and safe for its sedative, anxiolytic, and anticonvulsant effects. However, there has been no investigation on the influence of i.n. administration on midazolam-induced anterograde amnesia. In addition, although the potential of direct drug delivery from the nose to the central nervous system (CNS) has recently become a topic of great interest, it remains unclear whether this pathway is also involved after i.n. midazolam. In this ... περισσότερα »
Satisfaction and safety using dexmedetomidine or propofol sedation during endoscopic oesophageal procedures: A randomised controlled trial.
Satisfaction and safety using dexmedetomidine or propofol sedation during endoscopic oesophageal procedures: A randomised controlled trial.: BACKGROUND: Dexmedetomidine possesses anxiolytic and hypnotic properties without respiratory side-effects, making it theoretically an ideal sedative agent for endoscopic procedures. OBJECTIVE: We aimed to compare satisfaction and safety among outpatients receiving sedation with dexmedetomidine or propofol for endoscopic oesophageal procedures. DESIGN: A randomised controlled study. SETTING: Endoscopic intervention suite at the Academic Medical... περισσότερα »
Intraoperative hypotension is associated with myocardial damage in noncardiac surgery: An observational study.
Intraoperative hypotension is associated with myocardial damage in noncardiac surgery: An observational study.: BACKGROUND: Perioperative myocardial damage and infarction (MI) is associated with increased mortality and other postoperative complications. OBJECTIVES: To assess the incidence of perioperative myocardial damage in patients undergoing major elective noncardiac surgery, to elucidate any association with postoperative MI and mortality and to estimate the impact of preoperative risk factors and intraoperative hypotension. DESIGN: Observational cohort study. SETTING: Karolin... περισσότερα »
Patient with chronic renal failure undergoing surgery.
Patient with chronic renal failure undergoing surgery.: Purpose of review: Chronic kidney disease (CKD) is an increasing health problem worldwide and is associated with a number of clinical challenges. In this paper, we review recent studies that deal with strategies for the management of patients with CKD undergoing surgery. Recent findings: Effective strategies for nephroprotection are crucial for the handling of patients with CKD in the perioperative setting to prevent complications and to avoid the progression of CKD. Due to the lack of perioperative studies with CKD patients th... περισσότερα »
Immer wieder Nasenbluten
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Epistaxis Ein 46-jähriger Patient stellt sich mit wiederholtem Nasenbluten rechts vor. Da die Blutung auch nach mehrfachem Abtupfen mit Taschentüchern nicht zum Stillstand kommt, sucht er nun die Arztpraxis auf. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QZ1ul4 via IFTTT
Inflammatory Signaling in Pancreatic Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
We aimed to investigate the mechanistic, functional, and therapeutic role of glycogen synthase kinase 3β (GSK-3β) in the regulation and activation of the proinflammatory oncogenic transcription factor nuclear factor of activated T cells (NFATc2) in pancreatic cancer. IHC, qPCR, immunoblotting, immunofluorescence microscopy, and proliferation assays were used to analyze mouse and human tissues and cell […]
Rapamycin Dosage
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
The mTOR pathway is a critical regulator of cell growth, proliferation, metabolism, and survival. Dysregulation of mTOR signaling has been observed in most cancers and, thus, the mTOR pathway has been extensively studied for therapeutic intervention. Rapamycin is a natural product that inhibits mTOR with high specificity. However, its efficacy varies by dose in several […]
HSP90 Inhibition Kills Mutant KRAS Colon Cancer Cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Oncogenic mutations of KRAS pose a great challenge in the treatment of colorectal cancer. Here we report that mutant KRAS colon cancer cells are nevertheless more susceptible to apoptosis induced by the HSP90 inhibitor AUY922 than those carrying wild-type KRAS. Although AUY922 inhibited HSP90 activity with comparable potency in colon cancer cells irrespective of their […]
A Novel RAF Inhibitor with DFG-Out-Binding Mode
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive) conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF–mutant melanoma cells with 100x higher potency (1–10 nmol/L) than vemurafenib, whereas wild-type cells were not affected at 1,000 nmol/L. BI 882370 administered orally was efficacious in multiple […]
Selected Articles from This Issue
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YkVQj1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Preclinical Studies of SKLB646 against TNBC
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Triple-negative breast cancer (TNBC) is the most aggressive and deadly breast cancer subtype. To date, chemotherapy is the only systemic therapy and prognosis remains poor. Herein, we report the preclinical evaluation of SKLB646 in the treatment of TNBC; SKLB646 is a novel multiple kinase inhibitor developed by us recently. This compound potently inhibited SRC and […]
HMGB1 Predicts Radiotherapy Response in Bladder Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Although radical cystectomy surgery is the standard-of-care for muscle-invasive bladder cancer, it entails complete removal of the bladder and surrounding organs which leads to substantial loss in the quality-of-life of patients. Radiotherapy, which spares the bladder, would be a more appropriate treatment modality if we can utilize molecular markers to select patients with better response […]
WIP1 Inhibitor GSK2830371 Potentiates Nutlin-3/RG7388 Sensitivity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Sensitivity to MDM2 inhibitors is widely different among responsive TP53 wild-type cell lines and tumors. Understanding the determinants of MDM2 inhibitor sensitivity is pertinent for their optimal clinical application. Wild-type p53-inducible phosphatase-1 (WIP1) encoded by PPM1D, is activated, gained/amplified in a range of TP53 wild-type malignancies, and is involved in p53 stress response homeostasis. We […]
miR-137 Regulation of Sp1 Protein Translation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 9 δευτερόλεπτα
Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0–G1 arrest as well as downregulation of Cyclin D1 expression at transcriptional level via inhibition of Sp1 transactivation in bladder cancer cells. In the current study, the potential ISO inhibition of bladder tumor formation […]
The IFN-{beta} Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration [TUMOR IMMUNOLOGY]
In Vivo Visualizing the IFN-{beta} Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration [TUMOR IMMUNOLOGY]: The crucial role that endogenously produced IFN-β plays in eliciting an immune response against cancer has recently started to be elucidated. Endogenous IFN-β has an important role in immune surveillance and control of tumor development. Accordingly, the role of TLR agonists as cancer therapeutic agents is being revisited via the strategy of intra/peritumoral injection with the idea of stimulating the production of...περισσότερα »
Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control
Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control [IMMUNOTHERAPY AND VACCINES]: As a result of the difficulties in making efficient vaccines against genetically unstable viruses such as HIV, it has been suggested that future vaccines should preferentially target subdominant epitopes, the idea being that this should allow a greater breadth of the induced T cell response and, hence, a greater efficiency in controlling escape variants. However, to our knowledge the evidence su...περισσότερα »
Oral Immunization with Live Pneumocystis murina Protects against Pneumocystis Pneumonia
Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia [IMMUNOTHERAPY AND VACCINES]: *Pneumocystis* pneumonia is a major cause of morbidity and mortality in immunocompromised patients, particularly those infected with HIV. In this study, we evaluated the potential of oral immunization with live *Pneumocystis* to elicit protection against respiratory infection with *Pneumocystis murina*. C57BL/6 mice vaccinated with live *P. murina* using a prime-boost vaccination strategy were protected from a subsequent lung challenge with *P. murina* at 2,...περισσότερα »
Medical Complications of Tattoos: A Comprehensive Review
Medical Complications of Tattoos: A Comprehensive Review: AbstractTattoos are defined as the introduction of exogenous pigments into the dermis in order to produce a permanent design. This process may occur unintentional or may be deliberately administered for cosmetic or medical reasons. Tattoos have been around for over 5000 years and over time have evolved to represent a common cosmetic practice worldwide. Currently, adverse reactions are relatively rare and generally unpredictable and predominantly include immune-mediated reactions and skin infections. Along with better healthc...περισσότερα »
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T-cell activation
IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis via Allergy and Clinical Immunology Publication date: Available online 4 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Stéphanie Humblet-Baron, Dean Franckaert, James Dooley, Simon Bornschein, Bénédicte Cauwe, Susann Schönefeldt, Xavier Bossuyt, Patrick Matthys, Frédéric Baron, Carine Wouters, Adrian Liston BackgroundHemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T-cell... περισσότερα »
Current and Emerging Therapies for IgE-Mediated Food Allergy
Current and Emerging Therapies for IgE-Mediated Food Allergy: AbstractFood allergies are a growing clinical problem leading to increased health care utilization and decreases in patient quality of life. Current treatment recommendations include strict dietary avoidance of the offending food as well as use of self-injectable epinephrine in case of accidental exposure with allergic reaction. Although many individuals will eventually outgrow their food allergies, a substantial number will not. Significant effort has been made to find novel treatments that protect patients from food-tr... περισσότερα »
Peanut T-cell epitope discovery: Ara h 1
Peanut T-cell epitope discovery: Ara h 1 via Allergy and Clinical Immunology Publication date: Available online 4 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Manish Ramesh, Araya Yuenyongviwat, George N. Konstantinou, Jay Lieberman, Mariona Pascal, Madhan Masilamani, Hugh A. Sampson BackgroundIdentification of potential T-cell epitopes in the peanut major allergens is essential for development of peptide-based immunotherapy. Traditional methods of T-cell epitope discovery use overlapping short peptides spanning the full length of the protein in T-cell proli...περισσότερα »
Primary Sjogren's syndrome patient with dermatomyositis and diffuse large B-cell lymphoma
Histological improvement in salivary gland along with effector memory Th17-1 cell reduction in a primary Sjogren's syndrome patient with dermatomyositis and diffuse large B-cell lymphoma by R-CHOP therapy via Clinical Immunology Publication date: Available online 4 March 2016 *Source:*Clinical Immunology Author(s): Tomohiro Koga, Akinari Mizokami, Masahiro Nakashima, Toshimasa Shimizu, Yoshikazu Nakashima, Hideki Nakamura, Masahiko Chiwata, Niino Daisuke, Atsushi Kawakami We treated a 45-year-old Japanese woman with primary Sjogren's syndrome (SS) complicated with dermatomyositis (DM) ... περισσότερα »
Component-resolved diagnosis in anaphylaxis.hymenoptera venom (Api m1, Ves v 1, Ves v 5, and Pol d 5), food allergy (seed storage proteins and nonspecific lipid transfer proteins), cofactor-enhanced food allergy ([omega]-5-gliadine, nonspecific lipid transfer proteins), red meat delayed anaphylaxis ([alpha]-gal), latex allergy (Hev b 1, Hev b 3, Hev b 5, and Hev b 6), and Anisakis allergy (Ani s 1, Ani s 4, Ani s 7, and Ani s 13);
Component-resolved diagnosis in anaphylaxis.: Purpose of review: Component-resolved diagnosis (CRD) is an advanced tool capable of aiding the clinician in fine tuning the diagnosis of the causal allergens of a reaction with the added value of providing information of severity risk, potential cross-reactivity, and subsequently, guiding management measures. This review will focus on the advantages of CRD of anaphylaxis in clinical practice. Recent findings: *Research is continuously providing insight to which molecules are associated with genuine sensitization and/or potential sev... περισσότερα »
Thymus medulla under construction
Thymus medulla under construction: Time and Space Oddities: The development of effective T-cell-based immunotherapies to treat infection, cancer and autoimmunity should incorporate the ground rules that control differentiation of T cells in the thymus. Within the thymus, thymic epithelial cells (TECs) provide microenvironments supportive of the generation and selection of T cells that are responsive to pathogen-derived antigens, and yet tolerant to self-determinants. Defects in TEC differentiation cause syndromes that range from immunodeficiency to autoimmunity, which makes the stu... περισσότερα »
Simultaneous gap arthroplasty and intraoral distraction and secondary contouring surgery for unilateral temporomandibular joint ankylosis
Simultaneous gap arthroplasty and intraoral distraction and secondary contouring surgery for unilateral temporomandibular joint ankylosis: Abstract BackgroundTemporomandibular joint (TMJ) ankylosis can be accompanied by various degrees of functional and esthetic problems. Adequate mouth opening, occlusal stability, and harmonious facial form are the main goals of treatment for ankylosis. Distraction osteogenesis has proven to be an excellent treatment for lengthening the ramus-condyle unit. However, various timings for distraction have been suggested, and there is no consensus on ...περισσότερα »
Esomeprazole, minocycline, metronidazole and bismuth as first-line and second-line regimens for Helicobacter pylori eradication
Esomeprazole, minocycline, metronidazole and bismuth as first-line and second-line regimens for Helicobacter pylori eradication: ABSTRACT OBJECTIVE Because of general unavailability of tetracycline, relatively high adverse effect risk and complicated administration, the clinical application of bismuth quadruple therapy often faces great difficulty. Whether minocycline can replace tetracycline for *Helicobacter pylori* eradication remains unclear. The aim of this study was to determine the efficacy, safety, compliance and risk factors of esomeprazole, minocycline, metronidazole and ...περισσότερα »
Barrett's adenocarcinoma with marked endoscopic morphological changes in Barrett's esophagus over a long follow-up period of 15 years
A case of Barrett's adenocarcinoma with marked endoscopic morphological changes in Barrett's esophagus over a long follow-up period of 15 years: ABSTRACT The natural history of Barrett's esophagus (BE) is unclear. We herein describe a case of Barrett's adenocarcinoma (BAC) in which we could closely observe marked morphological changes in BE over a long follow-up period of 15 years. A man in his seventies received routine esophagogastroduodenoscopy (EGD) and was diagnosed as having reflux esophagitis and short segment BE. The BE gradually became elongated, and BAC was detected nine ... περισσότερα »
Paraesophageal parasitic thyroid protuberance
Paraesophageal parasitic thyroid protuberance, a diagnosis using Endoscopic Ultrasound:
Cytokines during Wound healing
Cytokines during periodontal wound healing: potential application for new therapeutic approach by David Nicolas Morand, Jean-Luc Davideau, François Clauss, Nadia Jessel, Henri Tenenbaum, Olivier Huck via Oral Diseases Abstract Regeneration of periodontal tissues is one of the main goals of periodontal therapy. However, current treatment, including surgical approach, use of membrane to allow maturation of all periodontal tissues or use of enamel matrix derivatives present limitations in their indications and outcomes leading to the development of new tissue engineering strategies. Seve...περισσότερα »
Posterior mandibular widening secondary to advancement sagittal split osteotomy
: A retrospective study via Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Publication date: Available online 3 March 2016 *Source:*Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale Author(s): N. Sigaux, M. Lahon, D. Maucort-Boulch, P. Bouletreau IntroductionPatients sometimes spontaneously report a modification of the width of their lower face after an advancement bilateral sagittal split osteotomy (ABSSO). The main goal of our study was to assess the variation of the bigonial distance (BGD) before and after ABSSO in a group of patie...περισσότερα »
Predicting ground contact events for a continuum of gait types
: An application of targeted machine learning using principal component analysis via Gait & Posture Publication date: Available online 4 March 2016 *Source:*Gait & Posture Author(s): Sean T. Osis, Blayne A. Hettinga, Reed Ferber An ongoing challenge in the application of gait analysis to clinical settings is the standardized detection of temporal events, with unobtrusive and cost-effective equipment, for a wide range of gait types. The purpose of the current study was to investigate a targeted machine learning approach for the prediction of timing for foot strike (or initial contact) ... περισσότερα »
Wound Healing Concepts in Clinical Practice of Maxillofacial and Oral Surgery
Wound Healing Concepts in Clinical Practice of OMFS: Abstract BackgroundWound healing is a complex and dynamic process and a thorough knowledge of the basics of physiology of wound healing is a must to implement principles of chronic wound care. Understanding wound healing at multiple levels—biochemical, physiologic, cellular and molecular provides the surgeon with a framework for basing clinical decisions aimed at optimizing the healing response. ObjectiveThis review article describes the classification of wounds and aims to highlight the fundamentals of wound repair, enumerati... περισσότερα »
Pendred syndrome is a rare autosomal recessive condition, characterized by functional impairment of thyroid gland and sensorineural hearing loss. The syndrome presents in patients with homozygous or compound heterozygous mutation. The presentation in the form of neck mass in a newborn is rare.
Pendred Syndrome in a Newborn with Neck Swelling: A Case Report.: J Trop Pediatr. 2016 Mar ; Authors: Ajij M, Shambhavi, Patra B, Singh A, Kapoor S Abstract BACKGROUND: Pendred syndrome is a rare autosomal recessive condition, characterized by functional impairment of thyroid gland and sensorineural hearing loss. The syndrome presents in patients with homozygous or compound heterozygous mutation. The presentation in the form of neck mass in a newborn is rare. CASE CHARACTERISTICS: A 1 month old baby presented to us with neck mass, which was found to be an enlarged thyroid gland. T... περισσότερα »
Late onset and high-frequency dominant hearing loss in a family with MYH9 disorder.
Late onset and high-frequency dominant hearing loss in a family with MYH9 disorder.: Eur Arch Otorhinolaryngol. 2016 Mar 4; Authors: Wasano K, Matsunaga T, Ogawa K, Kunishima S Abstract MYH9 disorder is a rare autosomal-dominant disorder. We previously reported that it is caused by mutations in the gene for nonmuscle myosin heavy chain IIA (NMMHC-IIA). MYH9 disorder causes congenital macrothrombocytopenia accompanied by progressive sensorineural hearing loss, nephropathy, and cataract. However, there are few reports that describe the audiological features of MYH9 disorder. The obj... περισσότερα »
iPod accelerometry predict age-related gait changes
Multiple gait parameters derived from via Gait & Posture Publication date: Available online 5 March 2016 *Source:*Gait & Posture Author(s): Nienke M Kosse, Nicolas Vuillerme, Tibor Hortobágyi, Claudine JC Lamoth IntroductionNormative data of how natural aging affects gait can serve as a frame of reference for changes in gait dynamics due to pathologies. Therefore, the present study aims 1) to identify gait variables sensitive to age-related changes in gait over the adult life span using the iPod and 2) to assess if these variables accurately distinguish young (aged 18-45) from health... περισσότερα »
Effects of a Single Dose Dexmedetomidine on Surgical Field Visibility During Middle Ear Microsurgery: A Randomized Study.
Effects of a Single Dose Dexmedetomidine on Surgical Field Visibility During Middle Ear Microsurgery: A Randomized Study.: Objectives: To investigate whether a single dose of dexmedetomidine (DEX) improves surgical field visibility. Study Design: Randomized, prospective, double-blind study. Setting: Tertiary teaching hospital. Interventions: ASA I or II patients undergoing tympanoplasty with ossiculoplasty were randomly assigned to receive either 0.8 [mu]g/kg DEX (Group D) or the same volume of saline (Group N) 10 min before anesthesia induction. Main Outcomes: The primary outcome... περισσότερα »
Assessment of Cochlear Trauma During Cochlear Implantation Using Electrocochleography and Cone Beam Computed Tomography.
Assessment of Cochlear Trauma During Cochlear Implantation Using Electrocochleography and Cone Beam Computed Tomography.: Objective: To assess cochlear trauma during cochlear implantation by electrocochleography (ECoG) and cone beam computed tomography (CBCT) and to correlate intraoperative cochlear trauma with postoperative loss of residual hearing. Methods: ECoG recordings to tone bursts at 250, 500, 750, and 1000 Hz and click stimuli were recorded before and after insertion of the cochlear implant electrode array, using an extracochlear recording electrode. CBCTs were conducted w... περισσότερα »
Intensive Care Medicine, Vol. 42, Issue 4 - New Issue Alert
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
If this email is not displayed correctly, please click here to read this table of contents online. New Issue Alert 03/07/2016 Dear Alexandros Sfakianakis, We are pleased to deliver your requested table of contents alert for *Intensive Care Medicine*. Volume 42 Number 4 is now available online. Important news Hospitalized patients at risk of dying - call for manuscripts Call for manuscripts on the topic of hospitalized patients at risk of dying. This new call is aimed at both medical and surgical researchers and is open to all specialties. We can fast-track these manuscripts,... περισσότερα »
Journal of Tropical Pediatrics - current issue
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
In this issue February 2016 Zika Virus Hematological Indices at Birth of Infants of HIV-Positive Mothers Participating in a Prevention of Mother-to-Child Transmission Program *Background:* The mother-to-child transmission of HIV, which accounts for 90% of infections in children, has been reduced markedly through the use of antiretroviral drugs by pregnant women and their newborns. Changes to the World Health Organization guidelines support further extension of the prevention of mother-to-child transmission programs with increased risk of toxicity on the fetuses. *Aim:* To determine... περισσότερα »
Thymus medulla under construction: Time and Space Oddities
The development of effective T-cell-based immunotherapies to treat infection, cancer and autoimmunity should incorporate the ground rules that control differentiation of T cells in the thymus. Within the thymus, thymic epithelial cells (TECs) provide microenvironments supportive of the generation and selection of T cells that are responsive to pathogen-derived antigens, and yet tolerant to self-determinants. Defects in TEC differentiation cause syndromes that range from immunodeficiency to autoimmunity, which makes the study of TECs of fundamental and clinical importance to compr... περισσότερα »
Sudden Death Due to Vestibular Schwannoma
Sudden Death Due to Vestibular Schwannoma: Caution in Emergent Management.: Objective: To enhance understanding of the possible dangers of large vestibular schwannomas and their potential to cause sudden death through rare situations such as brain herniation precipitated by cerebrospinal fluid pressure shifts. Patient: An otherwise healthy 32-year-old woman with a magnetic resonance imaging demonstrating a cystic cerebellopontine angle mass, presumptive for vestibular schwannoma, experienced sudden onset of headaches, nausea, and vomiting. Intervention: The patient was admitted to ...περισσότερα »
The Novel Affordable Telford Temporal Bone Holder
The Novel Affordable Telford Temporal Bone Holder: *Abstract* Surgical training is constantly evolving and junior trainees now perform fewer operations than ever. To maintain standards, greater emphasis is placed on simulation, often requiring attendance to expensive courses. While virtual reality systems have been developed recently, cadaveric dissection remains the cornerstone of training. To allow effective development of the essential finely tuned dextrous skills that are required by otologists there must be optimal tools available to the trainee, the most important being the... περισσότερα »
Oat-cell carcinoma of the tongue
Carcinoma neuroendocrino de célula pequeña de la lengua via Acta Otorrinolaringológica Española Publication date: Available online 5 March 2016 *Source:*Acta Otorrinolaringológica Española Author(s): Francina Aguilar, Miguel Cuadrado, Jordi Serra, Xana Bernal-Escoté [image: Tinción con Giemsa (×10). Extensión citológica procedente de punción-aspiración ...] [image: Corte sagital y axial en tomografía computarizada donde puede observarse la ...]
Craniofacial Shape in Children with and without a Positive Otitis Media History
Craniofacial Shape in Children with and without a Positive Otitis Media History via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Allison P. Gremba, Seth M. Weinberg, J. Douglas Swarts, Margaretha L. Casselbrant ObjectivePast studies using traditional morphometric approaches have reported a handful of differences in craniofacial dimensions between individuals with and without otitis media (OM). In this study, a geometric morphometry (GM) approach was used ... περισσότερα »
DFNB30 non-syndromic hearing impairment : A Novel Homozygous Mutation in MYO3A
Identification of a Novel Homozygous Mutation in MYO3A in a Chinese family with DFNB30 non-syndromic hearing impairment via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Ronggui Qu, Qing Sang, Yao Xu, Ruizhi Feng, Li Jin, Lin He, Lei Wang IntroductionHearing loss is a common sensory impairment. Several genetic loci or genes responsible for non-syndrome hearing loss have been identified, including the well-known deafness genes GJB2, MT-RNR1 and SLC26A4. MYO... περισσότερα »
Pre-adolescents with repaired cleft palate : Spectral moment analysis of affricates
Spectral moment analysis of affricates produced by Mandarin-speaking pre-adolescents with repaired cleft palate via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Chenghui Jiang, Tara L. Whitehill, Bradley McPherson, Manwa L. Ng ObjectiveTo explore the spectral differences in frication noise between aspirated and unaspirated affricates in typical Putonghua (standard Mandarin Chinese) pre-adolescent speakers, and to compare the spectral characteristics of aff...περισσότερα »
A novel causative gene for autosomal dominant nonsyndromic hearing loss (ADNSHL) : Spatial and temporal expression patterns of Osbpl2a and Osbpl2b
during zebrafish embryonic development via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Chunyu Liu, Jun Yao, Qinjun Wei, Guangqian Xing, Xin Cao ObjectiveThe mutated OSBPL2 (OMIM: 606731), encoding oxysterol binding protein-like protein 2, was recently identified as a novel causative gene for autosomal dominant nonsyndromic hearing loss (ADNSHL). We reported the expression patterns of Osbpl2 in zebrafish, in order to further understand the role of OSBPL2 ...περισσότερα »
Combined magnetic fields provide robust coverage for interbody and posterolateral lumbar spinal fusion sites
Abstract Electromagnetic fields generated by spinal bone growth stimulation devices have been computationally modelled to determine coverage of the lumbar spinal vertebrae. The underlying assumption of these models was that the electric field, but not the magnetic field, was therapeutically relevant. However, there are no published studies examining the therapeutic coverage of spinal fusion sites by stimulators utilizing combined magnetic fields. To assess the coverage, an anatomical model of the vertebrae and discs of the lumbar spine was developed to represent interbody and poste... περισσότερα »
Risk of Systemic Allergic Reactions to Allergen Immunotherapy
in a Pediatric Allergy Clinic in Turkey via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Semiha Bahceci Erdem, Hikmet Tekin Nacaroglu, Sait Karaman, Canan Sule Unsal Karkıner, Ilker Gunay, Done Dogan, Suna Asilsoy, Serdar Altınoz, Demet Can ObjectıvesEven though allergen immunotherapy is an effective treatment method that has been used on rhinitis, asthma and venom anaphylaxis for over 100 years, systemic reactions (SRs) limit the use of this treatment m...περισσότερα »
Chronic maxillary sinusitis in β Thalassemic pediatric patients : Radiological and clinical difficulties in the management
Radiological and clinical difficulties in the management of chronic maxillary sinusitis in β Thalassemic pediatric patients via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 5 March 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): R. Di Mauro, L. Greco, M. Melis, G. Manenti, R. Floris, P.G. Giacomini, M. Di Girolamo, S. Di Girolamo IntroductionBeta thalassemia is a blood dyscrasia that caused a marked expansion of active marrow spaces and extramedullary haematopoiesis results. In these patients various alteration... περισσότερα »
A Tumor-Selective Picornavirus Promotes Tumor Regression
Picornaviruses have emerged as promising cancer therapies due to their ability to drive cytotoxic cellular immune responses and for promoting oncolysis. These properties include preferential replication in tumor cells, the induction of strong innate and adaptive immune responses, and the ease with which their genomes can be manipulated. We have developed Theiler's murine encephalomyelitis virus (TMEV) as an immunotherapy vector that promotes strong adaptive immune responses to tumor antigens embedded within its genome. To further explore its usefulness as cancer therapy, we invest... περισσότερα »
A Novel RAF Inhibitor with DFG-Out-Binding Mode
BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive) conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF–mutant melanoma cells with 100x higher potency (1–10 nmol/L) than vemurafenib, whereas wild-type cells were not affected at 1,000 nmol/L. BI 882370 administered orally was efficacious in multiple mouse models of BRAF-mutant melanomas and colorectal carcinomas, and at 25 mg/kg twice daily showed superior efficacy compared with vemurafenib, dabrafenib, or trametinib (dosed to provide exposures reached in pati...περισσότερα »
A Tumor-Selective Picornavirus Promotes Tumor Regression
Picornaviruses have emerged as promising cancer therapies due to their ability to drive cytotoxic cellular immune responses and for promoting oncolysis. These properties include preferential replication in tumor cells, the induction of strong innate and adaptive immune responses, and the ease with which their genomes can be manipulated. We have developed Theiler's murine encephalomyelitis virus (TMEV) as an immunotherapy vector that promotes strong adaptive immune responses to tumor antigens embedded within its genome. To further explore its usefulness as cancer therapy, we invest... περισσότερα »
A Novel RAF Inhibitor with DFG-Out-Binding Mode
BI 882370 is a highly potent and selective RAF inhibitor that binds to the DFG-out (inactive) conformation of the BRAF kinase. The compound inhibited proliferation of human BRAF–mutant melanoma cells with 100x higher potency (1–10 nmol/L) than vemurafenib, whereas wild-type cells were not affected at 1,000 nmol/L. BI 882370 administered orally was efficacious in multiple mouse models of BRAF-mutant melanomas and colorectal carcinomas, and at 25 mg/kg twice daily showed superior efficacy compared with vemurafenib, dabrafenib, or trametinib (dosed to provide exposures reached in pati...περισσότερα »
T-DM1 Induces Hepatotoxicity
Ado-trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) approved for the treatment of HER2-positive metastatic breast cancer. It consists of trastuzumab, a humanized mAb directed against HER2, and a microtubule inhibitor, DM1, conjugated to trastuzumab via a thioether linker. Hepatotoxicity is one of the serious adverse events associated with T-DM1 therapy. Mechanisms underlying T-DM1–induced hepatotoxicity… Continue reading T-DM1 Induces Hepatotoxicity
Tigecycline Inhibits Glioma Growth
Tigecycline is a broad-spectrum, first-in-class glycylcycline antibiotic currently used to treat complicated skin infections and community-acquired pneumonia. However, there is accumulating evidence showing that tigecycline has anticancer properties. In this study, we found tigecycline could inhibit cell proliferation by inducing cell-cycle arrest, but not apoptosis in glioma. To find the underlying mechanism of how tigecycline… Continue reading Tigecycline Inhibits Glioma Growth
TFAP2C Regulates Breast Cancer through EGFR
Expression of TFAP2C in luminal breast cancer is associated with reduced survival and hormone resistance, partially explained through regulation of RET. TFAP2C also regulates EGFR in HER2 breast cancer. We sought to elucidate the regulation and functional role of EGFR in luminal breast cancer. We used gene knockdown (KD) and treatment with a tyrosine kinase… Continue reading TFAP2C Regulates Breast Cancer through EGFR
Metformin Inhibits Urothelial Tumorigenesis
While pharmacoepidemiologic and laboratory studies have supported the hypothesis that the antidiabetic drug metformin may be useful in treating or preventing cancer, there is limited evidence to suggest which specific cancer sites may be particularly sensitive. Sensitivity likely is determined both by features of tumor pathophysiology and by pharmacokinetic factors. We used UPII-mutant Ha-ras transgenic… Continue reading Metformin Inhibits Urothelial Tumorigenesis
A Tumor-Selective Picornavirus Promotes Tumor Regression
Picornaviruses have emerged as promising cancer therapies due to their ability to drive cytotoxic cellular immune responses and for promoting oncolysis. These properties include preferential replication in tumor cells, the induction of strong innate and adaptive immune responses, and the ease with which their genomes can be manipulated. We have developed Theiler’s murine encephalomyelitis virus… Continue reading A Tumor-Selective Picornavirus Promotes Tumor Regression
Does a coupling capacitor enhance the charge balance during neural stimulation? An empirical study
Abstract Due to their DC-blocking characteristic, coupling capacitors are widely used to prevent potentially harmful charge buildup at the electrode–tissue interface. Although the capacitors can be an effective safety measure, it often seems overlooked that coupling capacitors actually introduce an offset voltage over the electrode–tissue interface as well. This work investigates this offset voltage both analytically and experimentally. The calculations as well as the experiments using bipolar-driven platinum electrodes in a saline solution confirm that coupling capacitors introduc... περισσότερα »
A laser Doppler system for monitoring cerebral microcirculation: implementation and evaluation during neurosurgery
Abstract The aim of this study was to adapt and evaluate laser Doppler perfusion monitoring (LDPM) together with custom-designed brain probes and software for continuous recording of cerebral microcirculation in patients undergoing neurosurgery. The LDPM system was used to record perfusion and backscattered light (TLI). These parameters were displayed together with the extracted heart rate (HR), pulsatility index (PI) and signal trends from adjustable time intervals. Technical evaluation was done on skin during thermal provocation. Clinical measurements were performed on ten patie...περισσότερα »
Effects of reconstructed magnetic field from sparse noisy boundary measurements on localization of active neural source
Abstract Localization of active neural source (ANS) from measurements on head surface is vital in magnetoencephalography. As neuron-generated magnetic fields are extremely weak, significant uncertainties caused by stochastic measurement interference complicate its localization. This paper presents a novel computational method based on reconstructed magnetic field from sparse noisy measurements for enhanced ANS localization by suppressing effects of unrelated noise. In this approach, the magnetic flux density (MFD) in the nearby current-free space outside the head is reconstructed ... περισσότερα »
Genetic effects on sleep/wake variation of seizures
[image: cover.gif?v=1&s=16d684b9258da6e17127038a] Summary Objective There is a complex bidirectional relationship between sleep and epilepsy. Sleep/wake timing of seizures has been investigated for several individual seizure types and syndromes, but few large-scale studies of the timing of seizures exist in people with varied epilepsy types. In addition, the genetic contributions to seizure timing have not been well studied. Methods Sleep/wake timing of seizures was determined for 1,395 subjects in 546 families enrolled in the Epilepsy Phenome/Genome Project (EPGP). We examined...περισσότερα »
WIP1 Inhibitor GSK2830371 Potentiates Nutlin-3/RG7388 Sensitivity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sensitivity to MDM2 inhibitors is widely different among responsive TP53 wild-type cell lines and tumors. Understanding the determinants of MDM2 inhibitor sensitivity is pertinent for their optimal clinical application. Wild-type p53-inducible phosphatase-1 (WIP1) encoded by PPM1D, is activated, gained/amplified in a range of TP53 wild-type malignancies, and is involved in p53 stress response homeostasis. We […]
miR-137 Regulation of Sp1 Protein Translation
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0–G1 arrest as well as downregulation of Cyclin D1 expression at transcriptional level via inhibition of Sp1 transactivation in bladder cancer cells. In the current study, the potential ISO inhibition of bladder tumor formation […]
CAR Agonist Improves CHOP-Based Chemotherapy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The constitutive androstane receptor (CAR and NR1i3) is a key regulator of CYP2B6, the enzyme predominantly responsible for the biotransformation of cyclophosphamide (CPA) to its pharmacologically active metabolite, 4-hydroxycyclophosphamide (4-OH-CPA). Previous studies from our laboratory illustrated that CAR activation increases the formation of 4-OH-CPA; however, CPA is rarely used clinically outside of combination therapies. Here, […]
Anti-Mesothelin ADC in Pancreatic and Ovarian Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
DMOT4039A, a humanized anti-mesothelin mAb conjugated to the antimitotic agent monomethyl auristatin E (MMAE), was given to patients with pancreatic and ovarian cancer every 3 weeks (0.2–2.8 mg/kg; q3w) or weekly (0.8–1.2 mg/kg). A 3+3 design was used for dose escalation followed by expansion at the recommended phase II dose (RP2D) to evaluate safety and […]
PIT with Viral HER2 Transduction for HER2-Negative Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Peritoneal dissemination is the most frequent metastasis in gastric cancer and is associated with poor prognosis. The lack of particular target antigens in gastric cancer other than HER2 has hampered the development of treatments for peritoneal dissemination of gastric cancer. We hypothesized that HER2-extracellular domain (HER2-ECD) gene transduction combined with trastuzumab-based photoimmunotherapy (PIT) might provide […]
Prosurvival Role of T-Type Ca2+ Channels in Ovarian Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ovarian cancer is the deadliest gynecologic cancer, due in large part to the diagnosis of advanced stage disease, the development of platinum resistance, and inadequate treatment alternatives. Recent studies by our group and others have shown that T-type calcium (Ca2+) channels play a reinforcing role in cancer cell proliferation, cell-cycle progression, and apoptosis evasion. Therefore, […]
Identifying a Novel MST4 Kinase Inhibitor
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Pituitary tumors of the gonadotrope lineage are often large and invasive, resulting in hypopituitarism. No medical treatments are currently available. Using a combined genetic and genomic screen of individual human gonadotrope pituitary tumor samples, we recently identified the mammalian sterile-20 like kinase 4 (MST4) as a protumorigenic effector, driving increased pituitary cell proliferation and survival […]
T-DM1 Induces Hepatotoxicity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Ado-trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) approved for the treatment of HER2-positive metastatic breast cancer. It consists of trastuzumab, a humanized mAb directed against HER2, and a microtubule inhibitor, DM1, conjugated to trastuzumab via a thioether linker. Hepatotoxicity is one of the serious adverse events associated with T-DM1 therapy. Mechanisms underlying T-DM1–induced hepatotoxicity […]
Tigecycline Inhibits Glioma Growth
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Tigecycline is a broad-spectrum, first-in-class glycylcycline antibiotic currently used to treat complicated skin infections and community-acquired pneumonia. However, there is accumulating evidence showing that tigecycline has anticancer properties. In this study, we found tigecycline could inhibit cell proliferation by inducing cell-cycle arrest, but not apoptosis in glioma. To find the underlying mechanism of how tigecycline […]
TFAP2C Regulates Breast Cancer through EGFR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Expression of TFAP2C in luminal breast cancer is associated with reduced survival and hormone resistance, partially explained through regulation of RET. TFAP2C also regulates EGFR in HER2 breast cancer. We sought to elucidate the regulation and functional role of EGFR in luminal breast cancer. We used gene knockdown (KD) and treatment with a tyrosine kinase […]
Thymus medulla under construction: Time and Space Oddities
The development of effective T-cell-based immunotherapies to treat infection, cancer and autoimmunity should incorporate the ground rules that control differentiation of T cells in the thymus. Within the thymus, thymic epithelial cells (TECs) provide microenvironments supportive of the generation and selection of T cells that are responsive to pathogen-derived antigens, and yet tolerant to self-determinants. Defects in TEC differentiation cause syndromes that range from immunodeficiency to autoimmunity, which makes the study of TECs of fundamental and clinical importance to compr... περισσότερα »
Long-term financing needs for HIV control in sub-Saharan Africa in 2015-2050: a modelling study
Objectives To estimate the present value of current and future funding needed for HIV treatment and prevention in 9 sub-Saharan African (SSA) countries that account for 70% of HIV burden in Africa under different scenarios of intervention scale-up. To analyse the gaps between current expenditures and funding obligation, and discuss the policy implications of future financing needs. Design We used the Goals module from Spectrum, and applied the most up-to-date cost and coverage data to provide a range of estimates for future financing obligations. The four different scale-up sce... περισσότερα »
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